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Network neighborhood for query Sequence : ATS13_MOUSE

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ATS13_MOUSE
SwissProt Accessions	Q769J6, Q76LW1	Gene names	Adamts13
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ATS13_HUMAN
θ value	0 (rank : 1)	NC score	0.989497 (rank : 2)
Query Neighborhood Hits	227	Target Neighborhood Hits	238	Shared Neighborhood Hits	152
SwissProt Accessions	Q76LX8, Q6UY16, Q710F6, Q711T8, Q96L37, Q9H0G3	Gene names	ADAMTS13, C9orf8
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

ATS13_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	227	Target Neighborhood Hits	227	Shared Neighborhood Hits	227
SwissProt Accessions	Q769J6, Q76LW1	Gene names	Adamts13
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

ATS18_MOUSE
θ value	4.77967e-110 (rank : 3)	NC score	0.943413 (rank : 5)
Query Neighborhood Hits	227	Target Neighborhood Hits	163	Shared Neighborhood Hits	124
SwissProt Accessions	Q4VC17, Q8BZD1	Gene names	Adamts18
Domain Architecture	No domain graphic available
Description	ADAMTS-18 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18).

ATS20_MOUSE
θ value	1.39067e-109 (rank : 4)	NC score	0.927488 (rank : 22)
Query Neighborhood Hits	227	Target Neighborhood Hits	225	Shared Neighborhood Hits	127
SwissProt Accessions	P59511	Gene names	Adamts20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

ATS18_HUMAN
θ value	1.81628e-109 (rank : 5)	NC score	0.939997 (rank : 7)
Query Neighborhood Hits	227	Target Neighborhood Hits	169	Shared Neighborhood Hits	125
SwissProt Accessions	Q8TE60, Q6P4R5, Q6ZWJ9	Gene names	ADAMTS18, ADAMTS21
Domain Architecture
Description	ADAMTS-18 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18).

ATS9_HUMAN
θ value	1.59114e-105 (rank : 6)	NC score	0.930675 (rank : 20)
Query Neighborhood Hits	227	Target Neighborhood Hits	219	Shared Neighborhood Hits	130
SwissProt Accessions	Q9P2N4, Q9NR29	Gene names	ADAMTS9, KIAA1312
Domain Architecture
Description	ADAMTS-9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 9) (ADAM-TS 9) (ADAM-TS9).

ATS16_HUMAN
θ value	2.71407e-105 (rank : 7)	NC score	0.934402 (rank : 15)
Query Neighborhood Hits	227	Target Neighborhood Hits	208	Shared Neighborhood Hits	128
SwissProt Accessions	Q8TE57, Q8IVE2	Gene names	ADAMTS16, KIAA2029
Domain Architecture
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

ATS12_HUMAN
θ value	5.85632e-100 (rank : 8)	NC score	0.932223 (rank : 19)
Query Neighborhood Hits	227	Target Neighborhood Hits	251	Shared Neighborhood Hits	123
SwissProt Accessions	P58397, Q6UWL3	Gene names	ADAMTS12
Domain Architecture
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

ATS16_MOUSE
θ value	2.90646e-99 (rank : 9)	NC score	0.934826 (rank : 13)
Query Neighborhood Hits	227	Target Neighborhood Hits	179	Shared Neighborhood Hits	126
SwissProt Accessions	Q69Z28, Q8K206	Gene names	Adamts16, Kiaa2029
Domain Architecture	No domain graphic available
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

ATS12_MOUSE
θ value	2.72037e-97 (rank : 10)	NC score	0.933344 (rank : 17)
Query Neighborhood Hits	227	Target Neighborhood Hits	220	Shared Neighborhood Hits	124
SwissProt Accessions	Q811B3, Q8BK92, Q8BKY1	Gene names	Adamts12
Domain Architecture	No domain graphic available
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

ATS2_MOUSE
θ value	2.15548e-94 (rank : 11)	NC score	0.944025 (rank : 4)
Query Neighborhood Hits	227	Target Neighborhood Hits	179	Shared Neighborhood Hits	127
SwissProt Accessions	Q8C9W3	Gene names	Adamts2
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

ATS3_HUMAN
θ value	3.67668e-94 (rank : 12)	NC score	0.940545 (rank : 6)
Query Neighborhood Hits	227	Target Neighborhood Hits	179	Shared Neighborhood Hits	134
SwissProt Accessions	O15072, Q9BXZ8	Gene names	ADAMTS3, KIAA0366
Domain Architecture
Description	ADAMTS-3 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 3) (ADAM-TS 3) (ADAM-TS3) (Procollagen II amino propeptide-processing enzyme) (Procollagen II N-proteinase) (PC II-NP).

ATS2_HUMAN
θ value	2.63489e-92 (rank : 13)	NC score	0.944861 (rank : 3)
Query Neighborhood Hits	227	Target Neighborhood Hits	179	Shared Neighborhood Hits	128
SwissProt Accessions	O95450	Gene names	ADAMTS2, PCINP, PCPNI
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

ATS17_HUMAN
θ value	3.56116e-89 (rank : 14)	NC score	0.938792 (rank : 8)
Query Neighborhood Hits	227	Target Neighborhood Hits	194	Shared Neighborhood Hits	139
SwissProt Accessions	Q8TE56	Gene names	ADAMTS17
Domain Architecture
Description	ADAMTS-17 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 17) (ADAM-TS 17) (ADAM-TS17).

ATS14_HUMAN
θ value	1.35324e-88 (rank : 15)	NC score	0.928261 (rank : 21)
Query Neighborhood Hits	227	Target Neighborhood Hits	382	Shared Neighborhood Hits	124
SwissProt Accessions	Q8WXS8, Q8TE55, Q8TEY8	Gene names	ADAMTS14
Domain Architecture
Description	ADAMTS-14 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 14) (ADAM-TS 14) (ADAM-TS14).

ATS1_MOUSE
θ value	3.0147e-88 (rank : 16)	NC score	0.932613 (rank : 18)
Query Neighborhood Hits	227	Target Neighborhood Hits	158	Shared Neighborhood Hits	118
SwissProt Accessions	P97857, O54768	Gene names	Adamts1
Domain Architecture
Description	ADAMTS-1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 1) (ADAM-TS 1) (ADAM-TS1).

ATS1_HUMAN
θ value	1.82896e-85 (rank : 17)	NC score	0.933571 (rank : 16)
Query Neighborhood Hits	227	Target Neighborhood Hits	159	Shared Neighborhood Hits	116
SwissProt Accessions	Q9UHI8, Q9NSJ8, Q9P2K0, Q9UH83, Q9UP80	Gene names	ADAMTS1, KIAA1346, METH1
Domain Architecture
Description	ADAMTS-1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 1) (ADAM-TS 1) (ADAM-TS1) (METH-1).

ATS15_HUMAN
θ value	6.08852e-81 (rank : 18)	NC score	0.936208 (rank : 9)
Query Neighborhood Hits	227	Target Neighborhood Hits	151	Shared Neighborhood Hits	117
SwissProt Accessions	Q8TE58	Gene names	ADAMTS15
Domain Architecture
Description	ADAMTS-15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 15) (ADAM-TS 15) (ADAM-TS15).

ATS19_HUMAN
θ value	8.22888e-78 (rank : 19)	NC score	0.924919 (rank : 24)
Query Neighborhood Hits	227	Target Neighborhood Hits	203	Shared Neighborhood Hits	125
SwissProt Accessions	Q8TE59	Gene names	ADAMTS19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

ATS19_MOUSE
θ value	2.64714e-76 (rank : 20)	NC score	0.925496 (rank : 23)
Query Neighborhood Hits	227	Target Neighborhood Hits	188	Shared Neighborhood Hits	126
SwissProt Accessions	P59509	Gene names	Adamts19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

ATS7_HUMAN
θ value	4.67263e-73 (rank : 21)	NC score	0.923272 (rank : 25)
Query Neighborhood Hits	227	Target Neighborhood Hits	169	Shared Neighborhood Hits	125
SwissProt Accessions	Q9UKP4	Gene names	ADAMTS7
Domain Architecture
Description	ADAMTS-7 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 7) (ADAM-TS 7) (ADAM-TS7).

ATS8_HUMAN
θ value	1.96316e-71 (rank : 22)	NC score	0.936136 (rank : 10)
Query Neighborhood Hits	227	Target Neighborhood Hits	145	Shared Neighborhood Hits	112
SwissProt Accessions	Q9UP79, Q9NZS0	Gene names	ADAMTS8, METH2
Domain Architecture
Description	ADAMTS-8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2) (METH- 8).

ATS5_HUMAN
θ value	1.71981e-67 (rank : 23)	NC score	0.920013 (rank : 26)
Query Neighborhood Hits	227	Target Neighborhood Hits	141	Shared Neighborhood Hits	112
SwissProt Accessions	Q9UNA0, Q9UKP2	Gene names	ADAMTS5, ADAMTS11, ADMP2
Domain Architecture
Description	ADAMTS-5 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 5) (ADAM-TS 5) (ADAM-TS5) (Aggrecanase-2) (ADMP-2) (ADAM-TS 11).

ATS5_MOUSE
θ value	1.71981e-67 (rank : 24)	NC score	0.919684 (rank : 27)
Query Neighborhood Hits	227	Target Neighborhood Hits	147	Shared Neighborhood Hits	114
SwissProt Accessions	Q9R001	Gene names	Adamts5
Domain Architecture
Description	ADAMTS-5 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 5) (ADAM-TS 5) (ADAM-TS5) (Aggrecanase-2) (ADMP-2) (Implantin).

ATS8_MOUSE
θ value	2.32439e-64 (rank : 25)	NC score	0.935112 (rank : 12)
Query Neighborhood Hits	227	Target Neighborhood Hits	139	Shared Neighborhood Hits	114
SwissProt Accessions	P57110	Gene names	Adamts8
Domain Architecture
Description	ADAMTS-8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2).

ATS4_HUMAN
θ value	5.7252e-63 (rank : 26)	NC score	0.934461 (rank : 14)
Query Neighborhood Hits	227	Target Neighborhood Hits	138	Shared Neighborhood Hits	110
SwissProt Accessions	O75173, Q5VTW2, Q6P4Q8, Q6UWA8, Q9UN83	Gene names	ADAMTS4, KIAA0688
Domain Architecture
Description	ADAMTS-4 precursor (EC 3.4.24.82) (A disintegrin and metalloproteinase with thrombospondin motifs 4) (ADAM-TS 4) (ADAM-TS4) (Aggrecanase-1) (ADMP-1).

ATS4_MOUSE
θ value	2.17557e-62 (rank : 27)	NC score	0.935371 (rank : 11)
Query Neighborhood Hits	227	Target Neighborhood Hits	145	Shared Neighborhood Hits	116
SwissProt Accessions	Q8BNJ2, Q8K384	Gene names	Adamts4
Domain Architecture	No domain graphic available
Description	ADAMTS-4 precursor (EC 3.4.24.82) (A disintegrin and metalloproteinase with thrombospondin motifs 4) (ADAM-TS 4) (ADAM-TS4) (Aggrecanase-1).

ATL3_HUMAN
θ value	1.84173e-61 (rank : 28)	NC score	0.780959 (rank : 35)
Query Neighborhood Hits	227	Target Neighborhood Hits	414	Shared Neighborhood Hits	91
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

ATS6_HUMAN
θ value	4.2656e-42 (rank : 29)	NC score	0.916071 (rank : 29)
Query Neighborhood Hits	227	Target Neighborhood Hits	141	Shared Neighborhood Hits	116
SwissProt Accessions	Q9UKP5	Gene names	ADAMTS6
Domain Architecture
Description	ADAMTS-6 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 6) (ADAM-TS 6) (ADAM-TS6).

ATL1_HUMAN
θ value	1.98146e-39 (rank : 30)	NC score	0.916555 (rank : 28)
Query Neighborhood Hits	227	Target Neighborhood Hits	93	Shared Neighborhood Hits	80
SwissProt Accessions	Q8N6G6, Q5T708, Q96RW4, Q9BXY3	Gene names	ADAMTSL1, ADAMTSR1
Domain Architecture
Description	ADAMTS-like protein 1 precursor (ADAMTSL-1) (Punctin-1).

ATS20_HUMAN
θ value	4.41421e-39 (rank : 31)	NC score	0.915596 (rank : 30)
Query Neighborhood Hits	227	Target Neighborhood Hits	192	Shared Neighborhood Hits	128
SwissProt Accessions	P59510	Gene names	ADAMTS20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

ATL2_HUMAN
θ value	1.02001e-27 (rank : 32)	NC score	0.874776 (rank : 34)
Query Neighborhood Hits	227	Target Neighborhood Hits	125	Shared Neighborhood Hits	84
SwissProt Accessions	Q86TH1, O60345	Gene names	ADAMTSL2, KIAA0605
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2).

ATL1_MOUSE
θ value	1.33217e-27 (rank : 33)	NC score	0.906472 (rank : 31)
Query Neighborhood Hits	227	Target Neighborhood Hits	80	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BLI0	Gene names	Adamtsl1
Domain Architecture
Description	ADAMTS-like protein 1 precursor (Punctin-1).

ATL2_MOUSE
θ value	1.73987e-27 (rank : 34)	NC score	0.875688 (rank : 33)
Query Neighborhood Hits	227	Target Neighborhood Hits	137	Shared Neighborhood Hits	87
SwissProt Accessions	Q7TSK7, Q3U0C8	Gene names	Adamtsl2, Kiaa0605, Tcp1
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2) (TSP1-repeats-containing protein 1) (TCP-1).

ATL5_HUMAN
θ value	7.56453e-23 (rank : 35)	NC score	0.905978 (rank : 32)
Query Neighborhood Hits	227	Target Neighborhood Hits	103	Shared Neighborhood Hits	75
SwissProt Accessions	Q6ZMM2, Q8IW95	Gene names	ADAMTSL5, THSD6
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 5 precursor (ADAMTSL-5) (Thrombospondin type-1 domain-containing protein 6).

CI094_HUMAN
θ value	2.43343e-21 (rank : 36)	NC score	0.604558 (rank : 38)
Query Neighborhood Hits	227	Target Neighborhood Hits	310	Shared Neighborhood Hits	75
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

HMCN1_HUMAN
θ value	1.38178e-16 (rank : 37)	NC score	0.304764 (rank : 102)
Query Neighborhood Hits	227	Target Neighborhood Hits	983	Shared Neighborhood Hits	129
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

TSP1_HUMAN
θ value	7.09661e-13 (rank : 38)	NC score	0.494613 (rank : 42)
Query Neighborhood Hits	227	Target Neighborhood Hits	389	Shared Neighborhood Hits	112
SwissProt Accessions	P07996, Q15667	Gene names	THBS1, TSP, TSP1
Domain Architecture
Description	Thrombospondin-1 precursor.

TSP1_MOUSE
θ value	7.09661e-13 (rank : 39)	NC score	0.494177 (rank : 44)
Query Neighborhood Hits	227	Target Neighborhood Hits	396	Shared Neighborhood Hits	115
SwissProt Accessions	P35441	Gene names	Thbs1, Tsp1
Domain Architecture
Description	Thrombospondin-1 precursor.

TSP2_HUMAN
θ value	9.26847e-13 (rank : 40)	NC score	0.489543 (rank : 47)
Query Neighborhood Hits	227	Target Neighborhood Hits	359	Shared Neighborhood Hits	113
SwissProt Accessions	P35442	Gene names	THBS2, TSP2
Domain Architecture
Description	Thrombospondin-2 precursor.

SEM5A_HUMAN
θ value	4.59992e-12 (rank : 41)	NC score	0.451732 (rank : 62)
Query Neighborhood Hits	227	Target Neighborhood Hits	177	Shared Neighborhood Hits	89
SwissProt Accessions	Q13591, O60408, Q1RLL9	Gene names	SEMA5A, SEMAF
Domain Architecture
Description	Semaphorin-5A precursor (Semaphorin F) (Sema F).

TSP2_MOUSE
θ value	1.02475e-11 (rank : 42)	NC score	0.491319 (rank : 46)
Query Neighborhood Hits	227	Target Neighborhood Hits	352	Shared Neighborhood Hits	113
SwissProt Accessions	Q03350	Gene names	Thbs2, Tsp2
Domain Architecture
Description	Thrombospondin-2 precursor.

SEM5A_MOUSE
θ value	1.33837e-11 (rank : 43)	NC score	0.442253 (rank : 64)
Query Neighborhood Hits	227	Target Neighborhood Hits	162	Shared Neighborhood Hits	85
SwissProt Accessions	Q62217	Gene names	Sema5a, Semaf, SemF
Domain Architecture
Description	Semaphorin-5A precursor (Semaphorin F) (Sema F).

BAI2_HUMAN
θ value	5.08577e-11 (rank : 44)	NC score	0.481966 (rank : 50)
Query Neighborhood Hits	227	Target Neighborhood Hits	332	Shared Neighborhood Hits	91
SwissProt Accessions	O60241, Q5T6K0, Q8NGW8	Gene names	BAI2
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 2 precursor.

SEM5B_HUMAN
θ value	8.67504e-11 (rank : 45)	NC score	0.437035 (rank : 66)
Query Neighborhood Hits	227	Target Neighborhood Hits	178	Shared Neighborhood Hits	86
SwissProt Accessions	Q9P283, Q6UY12	Gene names	SEMA5B, KIAA1445
Domain Architecture
Description	Semaphorin-5B precursor.

SEM5B_MOUSE
θ value	1.133e-10 (rank : 46)	NC score	0.438923 (rank : 65)
Query Neighborhood Hits	227	Target Neighborhood Hits	190	Shared Neighborhood Hits	87
SwissProt Accessions	Q60519	Gene names	Sema5b, Semag, SemG
Domain Architecture
Description	Semaphorin-5B precursor (Semaphorin G) (Sema G).

SSPO_MOUSE
θ value	1.133e-10 (rank : 47)	NC score	0.435162 (rank : 67)
Query Neighborhood Hits	227	Target Neighborhood Hits	800	Shared Neighborhood Hits	157
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

BAI2_MOUSE
θ value	1.9326e-10 (rank : 48)	NC score	0.479749 (rank : 52)
Query Neighborhood Hits	227	Target Neighborhood Hits	323	Shared Neighborhood Hits	91
SwissProt Accessions	Q8CGM1, Q3TYC8, Q3UN11, Q3UNE2, Q6PGN0	Gene names	Bai2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 2 precursor.

ADAM7_MOUSE
θ value	2.13673e-09 (rank : 49)	NC score	0.380818 (rank : 84)
Query Neighborhood Hits	227	Target Neighborhood Hits	200	Shared Neighborhood Hits	85
SwissProt Accessions	O35227	Gene names	Adam7
Domain Architecture
Description	ADAM 7 precursor (A disintegrin and metalloproteinase domain 7).

BAI1_MOUSE
θ value	2.79066e-09 (rank : 50)	NC score	0.480727 (rank : 51)
Query Neighborhood Hits	227	Target Neighborhood Hits	340	Shared Neighborhood Hits	92
SwissProt Accessions	Q3UHD1, Q3UH36, Q8CGM0	Gene names	Bai1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1 precursor.

CO8A_MOUSE
θ value	3.64472e-09 (rank : 51)	NC score	0.456106 (rank : 60)
Query Neighborhood Hits	227	Target Neighborhood Hits	182	Shared Neighborhood Hits	75
SwissProt Accessions	Q8K182, Q8CHJ9, Q8CHK1	Gene names	C8a
Domain Architecture	No domain graphic available
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

PROP_HUMAN
θ value	3.64472e-09 (rank : 52)	NC score	0.659219 (rank : 36)
Query Neighborhood Hits	227	Target Neighborhood Hits	126	Shared Neighborhood Hits	81
SwissProt Accessions	P27918, O15134, O15135, O15136, O75826	Gene names	CFP, PFC
Domain Architecture
Description	Properdin precursor (Factor P).

BAI1_HUMAN
θ value	4.76016e-09 (rank : 53)	NC score	0.478930 (rank : 53)
Query Neighborhood Hits	227	Target Neighborhood Hits	375	Shared Neighborhood Hits	94
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

PROP_MOUSE
θ value	8.11959e-09 (rank : 54)	NC score	0.651956 (rank : 37)
Query Neighborhood Hits	227	Target Neighborhood Hits	165	Shared Neighborhood Hits	87
SwissProt Accessions	P11680, Q3TB98, Q3U779	Gene names	Cfp, Pfc
Domain Architecture	No domain graphic available
Description	Properdin precursor (Factor P).

UNC5B_HUMAN
θ value	1.38499e-08 (rank : 55)	NC score	0.481990 (rank : 49)
Query Neighborhood Hits	227	Target Neighborhood Hits	225	Shared Neighborhood Hits	75
SwissProt Accessions	Q8IZJ1, Q86SN3, Q8N1Y2, Q9H9F3	Gene names	UNC5B, P53RDL1, UNC5H2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2) (p53-regulated receptor for death and life protein 1).

UNC5B_MOUSE
θ value	1.38499e-08 (rank : 56)	NC score	0.484450 (rank : 48)
Query Neighborhood Hits	227	Target Neighborhood Hits	226	Shared Neighborhood Hits	75
SwissProt Accessions	Q8K1S3, Q3U4F2, Q6PFH0, Q80Y85, Q9D398	Gene names	Unc5b, Unc5h2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2).

UNC5A_MOUSE
θ value	1.80886e-08 (rank : 57)	NC score	0.494505 (rank : 43)
Query Neighborhood Hits	227	Target Neighborhood Hits	203	Shared Neighborhood Hits	76
SwissProt Accessions	Q8K1S4, Q6PEF7, Q80T71	Gene names	Unc5a, Kiaa1976, Unc5h1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

CO7_HUMAN
θ value	3.08544e-08 (rank : 58)	NC score	0.410415 (rank : 73)
Query Neighborhood Hits	227	Target Neighborhood Hits	278	Shared Neighborhood Hits	88
SwissProt Accessions	P10643, Q6P3T5, Q92489	Gene names	C7
Domain Architecture
Description	Complement component C7 precursor.

BAI3_HUMAN
θ value	6.87365e-08 (rank : 59)	NC score	0.476190 (rank : 54)
Query Neighborhood Hits	227	Target Neighborhood Hits	246	Shared Neighborhood Hits	88
SwissProt Accessions	O60242, O60297	Gene names	BAI3, KIAA0550
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

BAI3_MOUSE
θ value	6.87365e-08 (rank : 60)	NC score	0.475267 (rank : 55)
Query Neighborhood Hits	227	Target Neighborhood Hits	250	Shared Neighborhood Hits	87
SwissProt Accessions	Q80ZF8	Gene names	Bai3
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

ADA19_MOUSE
θ value	8.97725e-08 (rank : 61)	NC score	0.414146 (rank : 71)
Query Neighborhood Hits	227	Target Neighborhood Hits	315	Shared Neighborhood Hits	91
SwissProt Accessions	O35674	Gene names	Adam19, Mltnb
Domain Architecture
Description	ADAM 19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 19) (Meltrin beta).

UNC5C_HUMAN
θ value	7.59969e-07 (rank : 62)	NC score	0.465134 (rank : 57)
Query Neighborhood Hits	227	Target Neighborhood Hits	226	Shared Neighborhood Hits	76
SwissProt Accessions	O95185, Q8IUT0	Gene names	UNC5C, UNC5H3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3).

UNC5C_MOUSE
θ value	7.59969e-07 (rank : 63)	NC score	0.465587 (rank : 56)
Query Neighborhood Hits	227	Target Neighborhood Hits	225	Shared Neighborhood Hits	76
SwissProt Accessions	O08747, Q8CD16	Gene names	Unc5c, Rcm, Unc5h3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3) (Rostral cerebellar malformation protein).

CILP2_HUMAN
θ value	9.92553e-07 (rank : 64)	NC score	0.420862 (rank : 69)
Query Neighborhood Hits	227	Target Neighborhood Hits	307	Shared Neighborhood Hits	73
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

ADAM7_HUMAN
θ value	1.29631e-06 (rank : 65)	NC score	0.381441 (rank : 83)
Query Neighborhood Hits	227	Target Neighborhood Hits	221	Shared Neighborhood Hits	88
SwissProt Accessions	Q9H2U9, O75959	Gene names	ADAM7, GP83
Domain Architecture
Description	ADAM 7 precursor (A disintegrin and metalloproteinase domain 7) (Sperm maturation-related glycoprotein GP-83).

UNC5D_HUMAN
θ value	2.21117e-06 (rank : 66)	NC score	0.456931 (rank : 59)
Query Neighborhood Hits	227	Target Neighborhood Hits	267	Shared Neighborhood Hits	78
SwissProt Accessions	Q6UXZ4, Q8WYP7	Gene names	UNC5D, KIAA1777, UNC5H4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

CO8A_HUMAN
θ value	2.88788e-06 (rank : 67)	NC score	0.456940 (rank : 58)
Query Neighborhood Hits	227	Target Neighborhood Hits	200	Shared Neighborhood Hits	78
SwissProt Accessions	P07357, Q13668, Q9H130	Gene names	C8A
Domain Architecture
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

UNC5D_MOUSE
θ value	2.88788e-06 (rank : 68)	NC score	0.453206 (rank : 61)
Query Neighborhood Hits	227	Target Neighborhood Hits	268	Shared Neighborhood Hits	79
SwissProt Accessions	Q8K1S2	Gene names	Unc5d, Unc5h4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

SPON1_HUMAN
θ value	3.77169e-06 (rank : 69)	NC score	0.594493 (rank : 39)
Query Neighborhood Hits	227	Target Neighborhood Hits	117	Shared Neighborhood Hits	85
SwissProt Accessions	Q9HCB6, O94862, Q8NCD7, Q8WUR5	Gene names	SPON1, KIAA0762, VSGP
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin) (Vascular smooth muscle cell growth- promoting factor).

SPON1_MOUSE
θ value	6.43352e-06 (rank : 70)	NC score	0.592649 (rank : 40)
Query Neighborhood Hits	227	Target Neighborhood Hits	123	Shared Neighborhood Hits	86
SwissProt Accessions	Q8VCC9, Q8K2Q8	Gene names	Spon1
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin).

UNC5A_HUMAN
θ value	6.43352e-06 (rank : 71)	NC score	0.407939 (rank : 74)
Query Neighborhood Hits	227	Target Neighborhood Hits	198	Shared Neighborhood Hits	73
SwissProt Accessions	Q6ZN44, Q8TF26, Q96GP4	Gene names	UNC5A, KIAA1976, UNC5H1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

CO6_HUMAN
θ value	1.09739e-05 (rank : 72)	NC score	0.444846 (rank : 63)
Query Neighborhood Hits	227	Target Neighborhood Hits	331	Shared Neighborhood Hits	93
SwissProt Accessions	P13671	Gene names	C6
Domain Architecture
Description	Complement component C6 precursor.

ADA15_MOUSE
θ value	2.44474e-05 (rank : 73)	NC score	0.348439 (rank : 89)
Query Neighborhood Hits	227	Target Neighborhood Hits	324	Shared Neighborhood Hits	104
SwissProt Accessions	O88839, Q3U7C2, Q8C7Z0, Q91VS9, Q9QYL2	Gene names	Adam15, Mdc15
Domain Architecture
Description	ADAM 15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 15) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein 15) (MDC-15) (Metalloprotease RGD disintegrin protein) (Metargidin) (AD56).

ADA19_HUMAN
θ value	2.44474e-05 (rank : 74)	NC score	0.404484 (rank : 76)
Query Neighborhood Hits	227	Target Neighborhood Hits	381	Shared Neighborhood Hits	87
SwissProt Accessions	Q9H013, Q9BZL5, Q9UHP2	Gene names	ADAM19, MLTNB
Domain Architecture
Description	ADAM 19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 19) (Meltrin beta) (Metalloprotease and disintegrin dentritic antigen marker) (MADDAM).

ADA15_HUMAN
θ value	7.1131e-05 (rank : 75)	NC score	0.376085 (rank : 85)
Query Neighborhood Hits	227	Target Neighborhood Hits	288	Shared Neighborhood Hits	97
SwissProt Accessions	Q13444, Q13493, Q96C78	Gene names	ADAM15, MDC15
Domain Architecture
Description	ADAM 15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 15) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein 15) (MDC-15) (Metalloprotease RGD disintegrin protein) (Metargidin).

THSD1_HUMAN
θ value	7.1131e-05 (rank : 76)	NC score	0.529559 (rank : 41)
Query Neighborhood Hits	227	Target Neighborhood Hits	136	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NS62, Q6P3U1, Q6UXZ2	Gene names	THSD1, TMTSP
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

ADA33_HUMAN
θ value	0.000121331 (rank : 77)	NC score	0.395450 (rank : 77)
Query Neighborhood Hits	227	Target Neighborhood Hits	264	Shared Neighborhood Hits	88
SwissProt Accessions	Q9BZ11, Q5JT75, Q5JT76, Q8N0W6	Gene names	ADAM33
Domain Architecture
Description	ADAM 33 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 33).

ADA25_MOUSE
θ value	0.000158464 (rank : 78)	NC score	0.322369 (rank : 95)
Query Neighborhood Hits	227	Target Neighborhood Hits	213	Shared Neighborhood Hits	89
SwissProt Accessions	Q9R159, Q9D4E4	Gene names	Adam25
Domain Architecture
Description	ADAM 25 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 25) (Testase 2).

ADAM9_MOUSE
θ value	0.00020696 (rank : 79)	NC score	0.373338 (rank : 86)
Query Neighborhood Hits	227	Target Neighborhood Hits	325	Shared Neighborhood Hits	92
SwissProt Accessions	Q61072, Q60618, Q61853, Q80U94	Gene names	Adam9, Kiaa0021, Mdc9, Mltng
Domain Architecture	No domain graphic available
Description	ADAM 9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 9) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) (Meltrin gamma).

CO8B_MOUSE
θ value	0.00020696 (rank : 80)	NC score	0.430253 (rank : 68)
Query Neighborhood Hits	227	Target Neighborhood Hits	224	Shared Neighborhood Hits	78
SwissProt Accessions	Q8BH35, Q4VAH1, Q8CHJ5, Q8CHJ6, Q8VC14	Gene names	C8b
Domain Architecture	No domain graphic available
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

ADAM9_HUMAN
θ value	0.000270298 (rank : 81)	NC score	0.362191 (rank : 88)
Query Neighborhood Hits	227	Target Neighborhood Hits	243	Shared Neighborhood Hits	85
SwissProt Accessions	Q13443, Q10718, Q8NFM6	Gene names	ADAM9, KIAA0021, MCMP, MDC9, MLTNG
Domain Architecture
Description	ADAM 9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 9) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) (Meltrin gamma) (Cellular disintegrin-related protein).

CO8B_HUMAN
θ value	0.000270298 (rank : 82)	NC score	0.392427 (rank : 79)
Query Neighborhood Hits	227	Target Neighborhood Hits	199	Shared Neighborhood Hits	70
SwissProt Accessions	P07358	Gene names	C8B
Domain Architecture
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

AD26A_MOUSE
θ value	0.000786445 (rank : 83)	NC score	0.314985 (rank : 98)
Query Neighborhood Hits	227	Target Neighborhood Hits	165	Shared Neighborhood Hits	80
SwissProt Accessions	Q9R158	Gene names	Adam26a, Adam26
Domain Architecture
Description	ADAM 26A precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 26A) (Testase-3).

ADA33_MOUSE
θ value	0.00102713 (rank : 84)	NC score	0.365145 (rank : 87)
Query Neighborhood Hits	227	Target Neighborhood Hits	231	Shared Neighborhood Hits	91
SwissProt Accessions	Q923W9	Gene names	Adam33
Domain Architecture
Description	ADAM 33 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 33).

ADA12_HUMAN
θ value	0.00134147 (rank : 85)	NC score	0.390841 (rank : 80)
Query Neighborhood Hits	227	Target Neighborhood Hits	224	Shared Neighborhood Hits	83
SwissProt Accessions	O43184, O60470	Gene names	ADAM12, MLTN
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

ADA24_MOUSE
θ value	0.00175202 (rank : 86)	NC score	0.329180 (rank : 93)
Query Neighborhood Hits	227	Target Neighborhood Hits	230	Shared Neighborhood Hits	85
SwissProt Accessions	Q9R160	Gene names	Adam24
Domain Architecture
Description	ADAM 24 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 24) (Testase 1).

ADA29_HUMAN
θ value	0.00175202 (rank : 87)	NC score	0.321289 (rank : 96)
Query Neighborhood Hits	227	Target Neighborhood Hits	247	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UKF5, Q9UHP1, Q9UKF3, Q9UKF4	Gene names	ADAM29
Domain Architecture
Description	ADAM 29 precursor (A disintegrin and metalloproteinase domain 29).

THSD1_MOUSE
θ value	0.00175202 (rank : 88)	NC score	0.492391 (rank : 45)
Query Neighborhood Hits	227	Target Neighborhood Hits	153	Shared Neighborhood Hits	75
SwissProt Accessions	Q9JM61, Q8C7Q9	Gene names	Thsd1, Tmtsp
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

ADA12_MOUSE
θ value	0.00228821 (rank : 89)	NC score	0.383979 (rank : 81)
Query Neighborhood Hits	227	Target Neighborhood Hits	474	Shared Neighborhood Hits	86
SwissProt Accessions	Q61824	Gene names	Adam12, Mltna
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

ADAM8_HUMAN
θ value	0.00298849 (rank : 90)	NC score	0.415881 (rank : 70)
Query Neighborhood Hits	227	Target Neighborhood Hits	327	Shared Neighborhood Hits	97
SwissProt Accessions	P78325	Gene names	ADAM8, MS2
Domain Architecture
Description	ADAM 8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 8) (Cell surface antigen MS2) (CD156a antigen) (CD156).

CILP1_MOUSE
θ value	0.0113563 (rank : 91)	NC score	0.304615 (rank : 103)
Query Neighborhood Hits	227	Target Neighborhood Hits	282	Shared Neighborhood Hits	75
SwissProt Accessions	Q66K08, Q7TSS0, Q7TSS1, Q8BV01	Gene names	Cilp
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

ADA21_MOUSE
θ value	0.0148317 (rank : 92)	NC score	0.332902 (rank : 91)
Query Neighborhood Hits	227	Target Neighborhood Hits	172	Shared Neighborhood Hits	78
SwissProt Accessions	Q9JI76	Gene names	Adam21, Adam31
Domain Architecture
Description	ADAM 21 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 21) (ADAM 31).

ADA28_MOUSE
θ value	0.0148317 (rank : 93)	NC score	0.406483 (rank : 75)
Query Neighborhood Hits	227	Target Neighborhood Hits	241	Shared Neighborhood Hits	83
SwissProt Accessions	Q9JLN6, Q8K5D2, Q8K5D3	Gene names	Adam28
Domain Architecture
Description	ADAM 28 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 28) (Thymic epithelial cell-ADAM) (TECADAM).

ADA10_HUMAN
θ value	0.0252991 (rank : 94)	NC score	0.249793 (rank : 114)
Query Neighborhood Hits	227	Target Neighborhood Hits	189	Shared Neighborhood Hits	78
SwissProt Accessions	O14672, Q10742, Q92650	Gene names	ADAM10, KUZ, MADM
Domain Architecture
Description	ADAM 10 precursor (EC 3.4.24.81) (A disintegrin and metalloproteinase domain 10) (Mammalian disintegrin-metalloprotease) (Kuzbanian protein homolog) (CDw156c antigen).

NFAC1_HUMAN
θ value	0.0252991 (rank : 95)	NC score	0.019860 (rank : 227)
Query Neighborhood Hits	227	Target Neighborhood Hits	312	Shared Neighborhood Hits	12
SwissProt Accessions	O95644, Q12865, Q15793	Gene names	NFATC1, NFAT2, NFATC
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcription complex cytosolic component) (NF-ATc1) (NF-ATc).

ADA10_MOUSE
θ value	0.0330416 (rank : 96)	NC score	0.251539 (rank : 113)
Query Neighborhood Hits	227	Target Neighborhood Hits	194	Shared Neighborhood Hits	79
SwissProt Accessions	O35598	Gene names	Adam10, Kuz, Madm
Domain Architecture
Description	ADAM 10 precursor (EC 3.4.24.81) (A disintegrin and metalloproteinase domain 10) (Mammalian disintegrin-metalloprotease) (Kuzbanian protein homolog).

ADA28_HUMAN
θ value	0.0330416 (rank : 97)	NC score	0.394699 (rank : 78)
Query Neighborhood Hits	227	Target Neighborhood Hits	244	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UKQ2, Q9Y339, Q9Y3S0	Gene names	ADAM28, MDCL
Domain Architecture
Description	ADAM 28 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 28) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein-L) (MDC-L) (eMDC II) (ADAM23).

ADA32_MOUSE
θ value	0.0330416 (rank : 98)	NC score	0.262778 (rank : 111)
Query Neighborhood Hits	227	Target Neighborhood Hits	219	Shared Neighborhood Hits	83
SwissProt Accessions	Q8K410, Q6P901, Q8BJ80	Gene names	Adam32
Domain Architecture	No domain graphic available
Description	ADAM 32 precursor (A disintegrin and metalloproteinase domain 32).

ADA32_HUMAN
θ value	0.0563607 (rank : 99)	NC score	0.264430 (rank : 110)
Query Neighborhood Hits	227	Target Neighborhood Hits	216	Shared Neighborhood Hits	79
SwissProt Accessions	Q8TC27, Q8TC42	Gene names	ADAM32
Domain Architecture	No domain graphic available
Description	ADAM 32 precursor (A disintegrin and metalloproteinase domain 32).

ADM1B_MOUSE
θ value	0.0563607 (rank : 100)	NC score	0.336507 (rank : 90)
Query Neighborhood Hits	227	Target Neighborhood Hits	236	Shared Neighborhood Hits	82
SwissProt Accessions	Q8R534, Q9R156	Gene names	Adam1b
Domain Architecture
Description	ADAM 1b precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 1b) (Fertilin alpha 1b subunit).

MMP13_MOUSE
θ value	0.0563607 (rank : 101)	NC score	0.053028 (rank : 169)
Query Neighborhood Hits	227	Target Neighborhood Hits	56	Shared Neighborhood Hits	37
SwissProt Accessions	P33435	Gene names	Mmp13
Domain Architecture
Description	Collagenase 3 precursor (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13).

ADA17_HUMAN
θ value	0.0736092 (rank : 102)	NC score	0.246414 (rank : 115)
Query Neighborhood Hits	227	Target Neighborhood Hits	223	Shared Neighborhood Hits	82
SwissProt Accessions	P78536, O60226	Gene names	ADAM17, CSVP, TACE
Domain Architecture
Description	ADAM 17 precursor (EC 3.4.24.86) (A disintegrin and metalloproteinase domain 17) (TNF-alpha-converting enzyme) (TNF-alpha convertase) (Snake venom-like protease) (CD156b antigen).

ADA17_MOUSE
θ value	0.0736092 (rank : 103)	NC score	0.258034 (rank : 112)
Query Neighborhood Hits	227	Target Neighborhood Hits	201	Shared Neighborhood Hits	80
SwissProt Accessions	Q9Z0F8, O88726, Q9R1U4, Q9Z0K3	Gene names	Adam17, Tace
Domain Architecture
Description	ADAM 17 precursor (EC 3.4.24.86) (A disintegrin and metalloproteinase domain 17) (TNF-alpha-converting enzyme) (TNF-alpha convertase) (CD156b antigen).

ADM1A_MOUSE
θ value	0.0736092 (rank : 104)	NC score	0.328587 (rank : 94)
Query Neighborhood Hits	227	Target Neighborhood Hits	230	Shared Neighborhood Hits	92
SwissProt Accessions	Q60813, Q60617, Q80WR7, Q8R533	Gene names	Adam1a, Adam1, Ftna
Domain Architecture
Description	ADAM 1a precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 1a) (Fertilin alpha 1a subunit).

MMP26_HUMAN
θ value	0.0736092 (rank : 105)	NC score	0.078745 (rank : 139)
Query Neighborhood Hits	227	Target Neighborhood Hits	56	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NRE1, Q9GZS2, Q9NR87	Gene names	MMP26
Domain Architecture
Description	Matrix metalloproteinase-26 precursor (EC 3.4.24.-) (MMP-26) (Matrilysin-2) (Endometase).

KR104_HUMAN
θ value	0.0961366 (rank : 106)	NC score	0.093424 (rank : 129)
Query Neighborhood Hits	227	Target Neighborhood Hits	313	Shared Neighborhood Hits	72
SwissProt Accessions	P60372	Gene names	KRTAP10-4, KAP10.4, KAP18-4, KRTAP10.4, KRTAP18-4, KRTAP18.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-4 (Keratin-associated protein 10.4) (High sulfur keratin-associated protein 10.4) (Keratin-associated protein 18-4) (Keratin-associated protein 18.4).

FRAS1_MOUSE
θ value	0.125558 (rank : 107)	NC score	0.097712 (rank : 127)
Query Neighborhood Hits	227	Target Neighborhood Hits	747	Shared Neighborhood Hits	108
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

KR107_HUMAN
θ value	0.125558 (rank : 108)	NC score	0.081579 (rank : 136)
Query Neighborhood Hits	227	Target Neighborhood Hits	330	Shared Neighborhood Hits	70
SwissProt Accessions	P60409, Q70LJ2	Gene names	KRTAP10-7, KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-7 (Keratin-associated protein 10.7) (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7).

NOTC2_HUMAN
θ value	0.125558 (rank : 109)	NC score	0.044177 (rank : 189)
Query Neighborhood Hits	227	Target Neighborhood Hits	1113	Shared Neighborhood Hits	104
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

SPR2K_MOUSE
θ value	0.125558 (rank : 110)	NC score	0.056621 (rank : 165)
Query Neighborhood Hits	227	Target Neighborhood Hits	28	Shared Neighborhood Hits	5
SwissProt Accessions	O70562	Gene names	Sprr2k
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2K.

LTBP2_HUMAN
θ value	0.163984 (rank : 111)	NC score	0.047012 (rank : 182)
Query Neighborhood Hits	227	Target Neighborhood Hits	552	Shared Neighborhood Hits	80
SwissProt Accessions	Q14767, Q99907, Q9NS51	Gene names	LTBP2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

MMP13_HUMAN
θ value	0.163984 (rank : 112)	NC score	0.049368 (rank : 177)
Query Neighborhood Hits	227	Target Neighborhood Hits	60	Shared Neighborhood Hits	36
SwissProt Accessions	P45452	Gene names	MMP13
Domain Architecture
Description	Collagenase 3 precursor (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13).

CILP1_HUMAN
θ value	0.279714 (rank : 113)	NC score	0.297483 (rank : 105)
Query Neighborhood Hits	227	Target Neighborhood Hits	266	Shared Neighborhood Hits	74
SwissProt Accessions	O75339, Q6UW99, Q8IYI5	Gene names	CILP
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) (Cartilage intermediate-layer protein) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

FBN2_MOUSE
θ value	0.279714 (rank : 114)	NC score	0.046816 (rank : 183)
Query Neighborhood Hits	227	Target Neighborhood Hits	549	Shared Neighborhood Hits	93
SwissProt Accessions	Q61555, Q63957	Gene names	Fbn2, Fbn-2
Domain Architecture
Description	Fibrillin-2 precursor.

MMP9_HUMAN
θ value	0.279714 (rank : 115)	NC score	0.049036 (rank : 178)
Query Neighborhood Hits	227	Target Neighborhood Hits	125	Shared Neighborhood Hits	40
SwissProt Accessions	P14780, Q3LR70, Q8N725, Q9H4Z1	Gene names	MMP9, CLG4B
Domain Architecture
Description	Matrix metalloproteinase-9 precursor (EC 3.4.24.35) (MMP-9) (92 kDa type IV collagenase) (92 kDa gelatinase) (Gelatinase B) (GELB) [Contains: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9].

MMP9_MOUSE
θ value	0.279714 (rank : 116)	NC score	0.052661 (rank : 171)
Query Neighborhood Hits	227	Target Neighborhood Hits	151	Shared Neighborhood Hits	42
SwissProt Accessions	P41245, Q06788, Q9DC02	Gene names	Mmp9, Clg4b
Domain Architecture
Description	Matrix metalloproteinase-9 precursor (EC 3.4.24.35) (MMP-9) (92 kDa type IV collagenase) (92 kDa gelatinase) (Gelatinase B) (GELB).

NOTC2_MOUSE
θ value	0.279714 (rank : 117)	NC score	0.045013 (rank : 185)
Query Neighborhood Hits	227	Target Neighborhood Hits	1069	Shared Neighborhood Hits	97
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

ADA30_HUMAN
θ value	0.365318 (rank : 118)	NC score	0.216772 (rank : 119)
Query Neighborhood Hits	227	Target Neighborhood Hits	391	Shared Neighborhood Hits	80
SwissProt Accessions	Q9UKF2, Q9UKF1	Gene names	ADAM30
Domain Architecture
Description	ADAM 30 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 30).

MMP2_HUMAN
θ value	0.365318 (rank : 119)	NC score	0.060567 (rank : 160)
Query Neighborhood Hits	227	Target Neighborhood Hits	79	Shared Neighborhood Hits	41
SwissProt Accessions	P08253	Gene names	MMP2, CLG4A
Domain Architecture
Description	72 kDa type IV collagenase precursor (EC 3.4.24.24) (72 kDa gelatinase) (Matrix metalloproteinase-2) (MMP-2) (Gelatinase A) (TBE- 1).

MMP2_MOUSE
θ value	0.365318 (rank : 120)	NC score	0.058870 (rank : 162)
Query Neighborhood Hits	227	Target Neighborhood Hits	77	Shared Neighborhood Hits	41
SwissProt Accessions	P33434	Gene names	Mmp2
Domain Architecture
Description	72 kDa type IV collagenase precursor (EC 3.4.24.24) (72 kDa gelatinase) (Matrix metalloproteinase-2) (MMP-2) (Gelatinase A).

ADAM8_MOUSE
θ value	0.47712 (rank : 121)	NC score	0.413914 (rank : 72)
Query Neighborhood Hits	227	Target Neighborhood Hits	326	Shared Neighborhood Hits	101
SwissProt Accessions	Q05910	Gene names	Adam8, Ms2
Domain Architecture
Description	ADAM 8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 8) (Cell surface antigen MS2) (Macrophage cysteine-rich glycoprotein) (CD156 antigen).

CELR2_MOUSE
θ value	0.47712 (rank : 122)	NC score	0.025967 (rank : 220)
Query Neighborhood Hits	227	Target Neighborhood Hits	584	Shared Neighborhood Hits	49
SwissProt Accessions	Q9R0M0, Q99K26, Q9Z2R4	Gene names	Celsr2
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 2 precursor (Flamingo 1) (mFmi1).

PCLO_MOUSE
θ value	0.47712 (rank : 123)	NC score	0.005955 (rank : 245)
Query Neighborhood Hits	227	Target Neighborhood Hits	2275	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

FIZ1_HUMAN
θ value	0.62314 (rank : 124)	NC score	-0.005205 (rank : 266)
Query Neighborhood Hits	227	Target Neighborhood Hits	715	Shared Neighborhood Hits	9
SwissProt Accessions	Q96SL8, Q6ZMJ7	Gene names	FIZ1
Domain Architecture	No domain graphic available
Description	Flt3-interacting zinc finger protein 1.

FOXO1_HUMAN
θ value	0.62314 (rank : 125)	NC score	0.006409 (rank : 244)
Query Neighborhood Hits	227	Target Neighborhood Hits	126	Shared Neighborhood Hits	2
SwissProt Accessions	Q12778, O43523, Q5VYC7, Q6NSK6	Gene names	FOXO1A, FKHR
Domain Architecture
Description	Forkhead box protein O1A (Forkhead in rhabdomyosarcoma).

LTBP4_MOUSE
θ value	0.62314 (rank : 126)	NC score	0.042966 (rank : 195)
Query Neighborhood Hits	227	Target Neighborhood Hits	607	Shared Neighborhood Hits	76
SwissProt Accessions	Q8K4G1, Q8K4G0	Gene names	Ltbp4
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).

MMP17_MOUSE
θ value	0.62314 (rank : 127)	NC score	0.043656 (rank : 193)
Query Neighborhood Hits	227	Target Neighborhood Hits	60	Shared Neighborhood Hits	32
SwissProt Accessions	Q9R0S3	Gene names	Mmp17, Mt4mmp
Domain Architecture
Description	Matrix metalloproteinase-17 precursor (EC 3.4.24.-) (MMP-17) (Membrane-type matrix metalloproteinase 4) (MT-MMP 4) (Membrane-type-4 matrix metalloproteinase) (MT4-MMP).

MMP28_HUMAN
θ value	0.62314 (rank : 128)	NC score	0.047200 (rank : 181)
Query Neighborhood Hits	227	Target Neighborhood Hits	55	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H239, Q96TE2	Gene names	MMP28, MMP25
Domain Architecture
Description	Matrix metalloproteinase-28 precursor (EC 3.4.24.-) (MMP-28) (Epilysin).

RUNX3_MOUSE
θ value	0.62314 (rank : 129)	NC score	0.011197 (rank : 238)
Query Neighborhood Hits	227	Target Neighborhood Hits	113	Shared Neighborhood Hits	3
SwissProt Accessions	Q64131, Q99P92, Q9R199	Gene names	Runx3, Aml2, Cbfa3, Pebp2a3
Domain Architecture
Description	Runt-related transcription factor 3 (Core-binding factor, alpha 3 subunit) (CBF-alpha 3) (Acute myeloid leukemia 2 protein) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEBP2-alpha C) (PEA2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit).

CSMD2_HUMAN
θ value	0.813845 (rank : 130)	NC score	0.010527 (rank : 240)
Query Neighborhood Hits	227	Target Neighborhood Hits	188	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z408, Q5VT59, Q8N963, Q96Q03, Q9H4V7, Q9H4V8, Q9H4V9, Q9H4W0, Q9H4W1, Q9H4W2, Q9H4W3, Q9H4W4, Q9HCY5, Q9HCY6, Q9HCY7	Gene names	CSMD2, KIAA1884
Domain Architecture
Description	CUB and sushi domain-containing protein 2 (CUB and sushi multiple domains protein 2).

FA53B_HUMAN
θ value	0.813845 (rank : 131)	NC score	0.025730 (rank : 221)
Query Neighborhood Hits	227	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q14153, Q8N5S6	Gene names	FAM53B, KIAA0140
Domain Architecture	No domain graphic available
Description	Protein FAM53B.

FA53B_MOUSE
θ value	0.813845 (rank : 132)	NC score	0.024887 (rank : 223)
Query Neighborhood Hits	227	Target Neighborhood Hits	29	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BGR5, Q3UGW1, Q8BI13	Gene names	Fam53b
Domain Architecture	No domain graphic available
Description	Protein FAM53B.

MMP25_HUMAN
θ value	0.813845 (rank : 133)	NC score	0.042919 (rank : 196)
Query Neighborhood Hits	227	Target Neighborhood Hits	56	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NPA2, Q9H3Q0	Gene names	MMP25, MT6MMP
Domain Architecture
Description	Matrix metalloproteinase-25 precursor (EC 3.4.24.-) (MMP-25) (Membrane-type matrix metalloproteinase 6) (MT-MMP 6) (Membrane-type-6 matrix metalloproteinase) (MT6-MMP) (Leukolysin).

MMP7_MOUSE
θ value	0.813845 (rank : 134)	NC score	0.068801 (rank : 144)
Query Neighborhood Hits	227	Target Neighborhood Hits	60	Shared Neighborhood Hits	48
SwissProt Accessions	Q10738	Gene names	Mmp7
Domain Architecture
Description	Matrilysin precursor (EC 3.4.24.23) (Pump-1 protease) (Uterine metalloproteinase) (Matrix metalloproteinase-7) (MMP-7) (Matrin).

WNT2_HUMAN
θ value	0.813845 (rank : 135)	NC score	0.004603 (rank : 250)
Query Neighborhood Hits	227	Target Neighborhood Hits	47	Shared Neighborhood Hits	3
SwissProt Accessions	P09544, Q75N05, Q9UDP9	Gene names	WNT2, IRP
Domain Architecture
Description	Protein Wnt-2 precursor (IRP protein) (Int-1-related protein).

ADAM2_MOUSE
θ value	1.06291 (rank : 136)	NC score	0.271150 (rank : 107)
Query Neighborhood Hits	227	Target Neighborhood Hits	209	Shared Neighborhood Hits	80
SwissProt Accessions	Q60718, Q60814, Q9D4G3, Q9QWJ0	Gene names	Adam2, Ftnb
Domain Architecture
Description	ADAM 2 precursor (A disintegrin and metalloproteinase domain 2) (Fertilin subunit beta) (PH-30) (PH30) (PH30-beta).

HGFL_MOUSE
θ value	1.06291 (rank : 137)	NC score	0.000938 (rank : 261)
Query Neighborhood Hits	227	Target Neighborhood Hits	188	Shared Neighborhood Hits	4
SwissProt Accessions	P26928	Gene names	Mst1, Hgfl
Domain Architecture
Description	Hepatocyte growth factor-like protein precursor (Macrophage stimulatory protein) (MSP) [Contains: Hepatocyte growth factor-like protein alpha chain; Hepatocyte growth factor-like protein beta chain].

KR106_HUMAN
θ value	1.06291 (rank : 138)	NC score	0.097515 (rank : 128)
Query Neighborhood Hits	227	Target Neighborhood Hits	347	Shared Neighborhood Hits	81
SwissProt Accessions	P60371	Gene names	KRTAP10-6, KAP10.6, KAP18-6, KRTAP10.6, KRTAP18-6, KRTAP18.6
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-6 (Keratin-associated protein 10.6) (High sulfur keratin-associated protein 10.6) (Keratin-associated protein 18-6) (Keratin-associated protein 18.6).

KR105_HUMAN
θ value	1.38821 (rank : 139)	NC score	0.059366 (rank : 161)
Query Neighborhood Hits	227	Target Neighborhood Hits	271	Shared Neighborhood Hits	64
SwissProt Accessions	P60370, Q70LJ3	Gene names	KRTAP10-5, KAP10.5, KAP18-5, KRTAP10.5, KRTAP18-5, KRTAP18.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-5 (Keratin-associated protein 10.5) (High sulfur keratin-associated protein 10.5) (Keratin-associated protein 18-5) (Keratin-associated protein 18.5).

NOTC3_HUMAN
θ value	1.38821 (rank : 140)	NC score	0.049484 (rank : 176)
Query Neighborhood Hits	227	Target Neighborhood Hits	1062	Shared Neighborhood Hits	107
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

SPRR3_MOUSE
θ value	1.38821 (rank : 141)	NC score	0.017307 (rank : 229)
Query Neighborhood Hits	227	Target Neighborhood Hits	106	Shared Neighborhood Hits	8
SwissProt Accessions	O09116	Gene names	Sprr3
Domain Architecture
Description	Small proline-rich protein 3 (Cornifin beta).

WISP2_MOUSE
θ value	1.38821 (rank : 142)	NC score	0.145695 (rank : 121)
Query Neighborhood Hits	227	Target Neighborhood Hits	129	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Z0G4, Q8CIC8	Gene names	Wisp2, Ccn5, Ctgfl
Domain Architecture
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L).

ADA21_HUMAN
θ value	1.81305 (rank : 143)	NC score	0.313673 (rank : 99)
Query Neighborhood Hits	227	Target Neighborhood Hits	181	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UKJ8, O43507	Gene names	ADAM21
Domain Architecture
Description	ADAM 21 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 21).

EZH2_HUMAN
θ value	1.81305 (rank : 144)	NC score	0.013518 (rank : 233)
Query Neighborhood Hits	227	Target Neighborhood Hits	84	Shared Neighborhood Hits	11
SwissProt Accessions	Q15910, Q15755, Q92857	Gene names	EZH2
Domain Architecture
Description	Enhancer of zeste homolog 2 (ENX-1).

EZH2_MOUSE
θ value	1.81305 (rank : 145)	NC score	0.014859 (rank : 232)
Query Neighborhood Hits	227	Target Neighborhood Hits	86	Shared Neighborhood Hits	13
SwissProt Accessions	Q61188, Q9R090	Gene names	Ezh2, Enx1h
Domain Architecture
Description	Enhancer of zeste homolog 2 (ENX-1).

KR102_HUMAN
θ value	1.81305 (rank : 146)	NC score	0.086533 (rank : 132)
Query Neighborhood Hits	227	Target Neighborhood Hits	264	Shared Neighborhood Hits	64
SwissProt Accessions	P60368, Q70LJ5	Gene names	KRTAP10-2, KAP10.2, KAP18-2, KRTAP10.2, KRTAP18-2, KRTAP18.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-2 (Keratin-associated protein 10.2) (High sulfur keratin-associated protein 10.2) (Keratin-associated protein 18-2) (Keratin-associated protein 18.2).

KR108_HUMAN
θ value	1.81305 (rank : 147)	NC score	0.047535 (rank : 180)
Query Neighborhood Hits	227	Target Neighborhood Hits	226	Shared Neighborhood Hits	53
SwissProt Accessions	P60410	Gene names	KRTAP10-8, KAP10.8, KAP18-8, KRTAP10.8, KRTAP18-8, KRTAP18.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-8 (Keratin-associated protein 10.8) (High sulfur keratin-associated protein 10.8) (Keratin-associated protein 18-8) (Keratin-associated protein 18.8).

LAMA5_MOUSE
θ value	1.81305 (rank : 148)	NC score	0.025502 (rank : 222)
Query Neighborhood Hits	227	Target Neighborhood Hits	828	Shared Neighborhood Hits	65
SwissProt Accessions	Q61001, Q9JHQ6	Gene names	Lama5
Domain Architecture
Description	Laminin alpha-5 chain precursor.

LAMB2_MOUSE
θ value	1.81305 (rank : 149)	NC score	0.019225 (rank : 228)
Query Neighborhood Hits	227	Target Neighborhood Hits	722	Shared Neighborhood Hits	57
SwissProt Accessions	Q61292, Q62182	Gene names	Lamb2, Lams
Domain Architecture
Description	Laminin beta-2 chain precursor (S-laminin) (S-LAM).

LTBP2_MOUSE
θ value	1.81305 (rank : 150)	NC score	0.042084 (rank : 201)
Query Neighborhood Hits	227	Target Neighborhood Hits	617	Shared Neighborhood Hits	72
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

MMP12_HUMAN
θ value	1.81305 (rank : 151)	NC score	0.044513 (rank : 187)
Query Neighborhood Hits	227	Target Neighborhood Hits	57	Shared Neighborhood Hits	37
SwissProt Accessions	P39900	Gene names	MMP12, HME
Domain Architecture
Description	Macrophage metalloelastase precursor (EC 3.4.24.65) (HME) (Matrix metalloproteinase-12) (MMP-12) (Macrophage elastase) (ME).

SPR2D_MOUSE
θ value	1.81305 (rank : 152)	NC score	0.034024 (rank : 216)
Query Neighborhood Hits	227	Target Neighborhood Hits	61	Shared Neighborhood Hits	10
SwissProt Accessions	O70555	Gene names	Sprr2d
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2D.

WISP2_HUMAN
θ value	1.81305 (rank : 153)	NC score	0.147978 (rank : 120)
Query Neighborhood Hits	227	Target Neighborhood Hits	126	Shared Neighborhood Hits	59
SwissProt Accessions	O76076	Gene names	WISP2, CCN5, CT58, CTGFL
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L) (Connective tissue growth factor-related protein 58).

ADA20_HUMAN
θ value	2.36792 (rank : 154)	NC score	0.268482 (rank : 109)
Query Neighborhood Hits	227	Target Neighborhood Hits	143	Shared Neighborhood Hits	78
SwissProt Accessions	O43506, Q9UKJ9	Gene names	ADAM20
Domain Architecture
Description	ADAM 20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 20).

ADA22_HUMAN
θ value	2.36792 (rank : 155)	NC score	0.320266 (rank : 97)
Query Neighborhood Hits	227	Target Neighborhood Hits	211	Shared Neighborhood Hits	80
SwissProt Accessions	Q9P0K1, O75075, O75076, Q9P0K2, Q9UIA1, Q9UKK2	Gene names	ADAM22, MDC2
Domain Architecture
Description	ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3).

ADA22_MOUSE
θ value	2.36792 (rank : 156)	NC score	0.311659 (rank : 100)
Query Neighborhood Hits	227	Target Neighborhood Hits	225	Shared Neighborhood Hits	85
SwissProt Accessions	Q9R1V6, Q5TLI8, Q5TLI9, Q5TLJ0, Q5TLJ1, Q5TLJ2, Q5TLJ3, Q5TLJ4, Q5TLJ5, Q5TLJ6, Q5TLJ7, Q5TLJ8, Q5TLJ9, Q5TLK0, Q5TLK1, Q5TLK2, Q5TLK3, Q5TLK4, Q5TLK5, Q5TLK6, Q5TLK7, Q5TLK8, Q8BSF2, Q9R1V5	Gene names	Adam22
Domain Architecture
Description	ADAM 22 precursor (A disintegrin and metalloproteinase domain 22).

KLF10_HUMAN
θ value	2.36792 (rank : 157)	NC score	-0.004852 (rank : 264)
Query Neighborhood Hits	227	Target Neighborhood Hits	744	Shared Neighborhood Hits	7
SwissProt Accessions	Q13118	Gene names	KLF10, TIEG, TIEG1
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 10 (Transforming growth factor-beta-inducible early growth response protein 1) (TGFB-inducible early growth response protein 1) (TIEG-1) (EGR-alpha).

KRA15_HUMAN
θ value	2.36792 (rank : 158)	NC score	0.048037 (rank : 179)
Query Neighborhood Hits	227	Target Neighborhood Hits	126	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BYS1, Q52LP6	Gene names	KRTAP1-5, KAP1.5, KRTAP1.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 1-5 (Keratin-associated protein 1.5) (High sulfur keratin-associated protein 1.5).

MMP15_MOUSE
θ value	2.36792 (rank : 159)	NC score	0.043980 (rank : 190)
Query Neighborhood Hits	227	Target Neighborhood Hits	102	Shared Neighborhood Hits	36
SwissProt Accessions	O54732	Gene names	Mmp15
Domain Architecture
Description	Matrix metalloproteinase-15 precursor (EC 3.4.24.-) (MMP-15) (Membrane-type matrix metalloproteinase 2) (MT-MMP 2) (MTMMP2) (Membrane-type-2 matrix metalloproteinase) (MT2-MMP) (MT2MMP).

MMP8_MOUSE
θ value	2.36792 (rank : 160)	NC score	0.041926 (rank : 202)
Query Neighborhood Hits	227	Target Neighborhood Hits	57	Shared Neighborhood Hits	35
SwissProt Accessions	O70138, O88733	Gene names	Mmp8
Domain Architecture
Description	Neutrophil collagenase precursor (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (Collagenase 2).

SREC_HUMAN
θ value	2.36792 (rank : 161)	NC score	0.049563 (rank : 175)
Query Neighborhood Hits	227	Target Neighborhood Hits	645	Shared Neighborhood Hits	92
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

TRI47_MOUSE
θ value	2.36792 (rank : 162)	NC score	0.003962 (rank : 254)
Query Neighborhood Hits	227	Target Neighborhood Hits	295	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C0E3, Q6P249, Q811J7, Q8BVZ8, Q8R1K0, Q8R3Y1	Gene names	Trim47
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47.

CUBN_MOUSE
θ value	3.0926 (rank : 163)	NC score	0.035327 (rank : 215)
Query Neighborhood Hits	227	Target Neighborhood Hits	477	Shared Neighborhood Hits	59
SwissProt Accessions	Q9JLB4	Gene names	Cubn, Ifcr
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor).

DIDO1_HUMAN
θ value	3.0926 (rank : 164)	NC score	0.004498 (rank : 252)
Query Neighborhood Hits	227	Target Neighborhood Hits	960	Shared Neighborhood Hits	17
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

DLL1_MOUSE
θ value	3.0926 (rank : 165)	NC score	0.042768 (rank : 198)
Query Neighborhood Hits	227	Target Neighborhood Hits	456	Shared Neighborhood Hits	82
SwissProt Accessions	Q61483	Gene names	Dll1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1).

KRA98_HUMAN
θ value	3.0926 (rank : 166)	NC score	0.074935 (rank : 142)
Query Neighborhood Hits	227	Target Neighborhood Hits	185	Shared Neighborhood Hits	49
SwissProt Accessions	Q9BYQ0	Gene names	KRTAP9-8, KAP9.8, KRTAP9.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-8 (Keratin-associated protein 9.8) (Ultrahigh sulfur keratin-associated protein 9.8).

LAMB2_HUMAN
θ value	3.0926 (rank : 167)	NC score	0.021578 (rank : 225)
Query Neighborhood Hits	227	Target Neighborhood Hits	692	Shared Neighborhood Hits	51
SwissProt Accessions	P55268, Q16321	Gene names	LAMB2, LAMS
Domain Architecture
Description	Laminin beta-2 chain precursor (S-laminin) (Laminin B1s chain).

MMP21_HUMAN
θ value	3.0926 (rank : 168)	NC score	0.041411 (rank : 204)
Query Neighborhood Hits	227	Target Neighborhood Hits	76	Shared Neighborhood Hits	33
SwissProt Accessions	Q8N119, Q8NG02	Gene names	MMP21
Domain Architecture	No domain graphic available
Description	Matrix metalloproteinase-21 precursor (EC 3.4.24.-) (MMP-21).

SELPL_MOUSE
θ value	3.0926 (rank : 169)	NC score	0.008005 (rank : 242)
Query Neighborhood Hits	227	Target Neighborhood Hits	588	Shared Neighborhood Hits	12
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

SPR2B_MOUSE
θ value	3.0926 (rank : 170)	NC score	0.033188 (rank : 217)
Query Neighborhood Hits	227	Target Neighborhood Hits	51	Shared Neighborhood Hits	11
SwissProt Accessions	O70554, Q7TSB2	Gene names	Sprr2b
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2B.

AATK_MOUSE
θ value	4.03905 (rank : 171)	NC score	-0.006121 (rank : 269)
Query Neighborhood Hits	227	Target Neighborhood Hits	942	Shared Neighborhood Hits	6
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).

DNER_MOUSE
θ value	4.03905 (rank : 172)	NC score	0.036715 (rank : 214)
Query Neighborhood Hits	227	Target Neighborhood Hits	413	Shared Neighborhood Hits	71
SwissProt Accessions	Q8JZM4, Q3U697, Q8R226, Q8R4T6, Q8VD97	Gene names	Dner, Bet, Bret
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor (Brain EGF repeat-containing transmembrane protein).

FRAS1_HUMAN
θ value	4.03905 (rank : 173)	NC score	0.079525 (rank : 138)
Query Neighborhood Hits	227	Target Neighborhood Hits	759	Shared Neighborhood Hits	103
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

GNDS_HUMAN
θ value	4.03905 (rank : 174)	NC score	0.004473 (rank : 253)
Query Neighborhood Hits	227	Target Neighborhood Hits	201	Shared Neighborhood Hits	9
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

KLF10_MOUSE
θ value	4.03905 (rank : 175)	NC score	-0.005152 (rank : 265)
Query Neighborhood Hits	227	Target Neighborhood Hits	741	Shared Neighborhood Hits	6
SwissProt Accessions	O89091	Gene names	Klf10, Gdnfif, Tieg, Tieg1
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 10 (Transforming growth factor-beta-inducible early growth response protein 1) (TGFB-inducible early growth response protein 1) (TIEG-1) (GDNF-inducible factor) (Transcription factor GIF) (mGIF).

MMP15_HUMAN
θ value	4.03905 (rank : 176)	NC score	0.039801 (rank : 209)
Query Neighborhood Hits	227	Target Neighborhood Hits	95	Shared Neighborhood Hits	34
SwissProt Accessions	P51511, Q14111	Gene names	MMP15
Domain Architecture
Description	Matrix metalloproteinase-15 precursor (EC 3.4.24.-) (MMP-15) (Membrane-type matrix metalloproteinase 2) (MT-MMP 2) (MTMMP2) (Membrane-type-2 matrix metalloproteinase) (MT2-MMP) (MT2MMP) (SMCP- 2).

MMP24_HUMAN
θ value	4.03905 (rank : 177)	NC score	0.042614 (rank : 199)
Query Neighborhood Hits	227	Target Neighborhood Hits	66	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y5R2, Q9H440	Gene names	MMP24, MT5MMP
Domain Architecture
Description	Matrix metalloproteinase-24 precursor (EC 3.4.24.-) (MMP-24) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP).

MMP24_MOUSE
θ value	4.03905 (rank : 178)	NC score	0.044609 (rank : 186)
Query Neighborhood Hits	227	Target Neighborhood Hits	71	Shared Neighborhood Hits	42
SwissProt Accessions	Q9R0S2, Q9Z0J9	Gene names	Mmp24, Mmp21, Mt5mmp
Domain Architecture
Description	Matrix metalloproteinase-24 precursor (EC 3.4.24.-) (MMP-24) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP) (MMP-21).

MMP8_HUMAN
θ value	4.03905 (rank : 179)	NC score	0.039420 (rank : 210)
Query Neighborhood Hits	227	Target Neighborhood Hits	54	Shared Neighborhood Hits	33
SwissProt Accessions	P22894, Q45F99	Gene names	MMP8, CLG1
Domain Architecture
Description	Neutrophil collagenase precursor (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (PMNL collagenase) (PMNL-CL).

NOV_MOUSE
θ value	4.03905 (rank : 180)	NC score	0.104509 (rank : 124)
Query Neighborhood Hits	227	Target Neighborhood Hits	130	Shared Neighborhood Hits	59
SwissProt Accessions	Q64299, Q8CA67	Gene names	Nov, Ccn3
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

PARC_HUMAN
θ value	4.03905 (rank : 181)	NC score	0.004566 (rank : 251)
Query Neighborhood Hits	227	Target Neighborhood Hits	148	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IWT3, O75188, Q68CP2, Q68D92, Q8N3W9, Q9BU56	Gene names	PARC, H7AP1, KIAA0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein (UbcH7-associated protein 1).

SPR1A_MOUSE
θ value	4.03905 (rank : 182)	NC score	0.013043 (rank : 234)
Query Neighborhood Hits	227	Target Neighborhood Hits	343	Shared Neighborhood Hits	22
SwissProt Accessions	Q62266	Gene names	Sprr1a
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein 1A) (SPR1A) (SPR1 A).

TM119_HUMAN
θ value	4.03905 (rank : 183)	NC score	0.012113 (rank : 236)
Query Neighborhood Hits	227	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	Q4V9L6, Q6UXE5, Q8N2F5	Gene names	TMEM119
Domain Architecture	No domain graphic available
Description	Transmembrane protein 119 precursor.

CSMD1_HUMAN
θ value	5.27518 (rank : 184)	NC score	0.008048 (rank : 241)
Query Neighborhood Hits	227	Target Neighborhood Hits	176	Shared Neighborhood Hits	11
SwissProt Accessions	Q96PZ7, Q96QU9, Q96RM4	Gene names	CSMD1, KIAA1890
Domain Architecture
Description	CUB and sushi domain-containing protein 1 precursor (CUB and sushi multiple domains protein 1).

DGKI_HUMAN
θ value	5.27518 (rank : 185)	NC score	0.000276 (rank : 262)
Query Neighborhood Hits	227	Target Neighborhood Hits	609	Shared Neighborhood Hits	8
SwissProt Accessions	O75912, Q9NZ49	Gene names	DGKI
Domain Architecture
Description	Diacylglycerol kinase iota (EC 2.7.1.107) (Diglyceride kinase iota) (DGK-iota) (DAG kinase iota).

EGFL7_HUMAN
θ value	5.27518 (rank : 186)	NC score	0.020722 (rank : 226)
Query Neighborhood Hits	227	Target Neighborhood Hits	325	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UHF1, Q5M7Y5, Q5VUD5, Q96EG0	Gene names	EGFL7, MEGF7
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 7 precursor (Multiple EGF-like domain protein 7) (Multiple epidermal growth factor-like domain protein 7) (Vascular endothelial statin) (VE-statin) (NOTCH4-like protein) (ZNEU1).

MLL2_HUMAN
θ value	5.27518 (rank : 187)	NC score	0.006762 (rank : 243)
Query Neighborhood Hits	227	Target Neighborhood Hits	1788	Shared Neighborhood Hits	39
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

MMP14_HUMAN
θ value	5.27518 (rank : 188)	NC score	0.043497 (rank : 194)
Query Neighborhood Hits	227	Target Neighborhood Hits	60	Shared Neighborhood Hits	37
SwissProt Accessions	P50281, Q92678	Gene names	MMP14
Domain Architecture
Description	Matrix metalloproteinase-14 precursor (EC 3.4.24.80) (MMP-14) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP) (MMP- X1).

MMP14_MOUSE
θ value	5.27518 (rank : 189)	NC score	0.043741 (rank : 191)
Query Neighborhood Hits	227	Target Neighborhood Hits	57	Shared Neighborhood Hits	35
SwissProt Accessions	P53690, O08645, O35369	Gene names	Mmp14, Mtmmp
Domain Architecture
Description	Matrix metalloproteinase-14 precursor (EC 3.4.24.80) (MMP-14) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP) (MMP-X1) (MT-MMP).

MMP3_MOUSE
θ value	5.27518 (rank : 190)	NC score	0.038780 (rank : 211)
Query Neighborhood Hits	227	Target Neighborhood Hits	53	Shared Neighborhood Hits	32
SwissProt Accessions	P28862	Gene names	Mmp3
Domain Architecture
Description	Stromelysin-1 precursor (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1) (SL-1) (EMS-2).

NOV_HUMAN
θ value	5.27518 (rank : 191)	NC score	0.092015 (rank : 130)
Query Neighborhood Hits	227	Target Neighborhood Hits	128	Shared Neighborhood Hits	55
SwissProt Accessions	P48745, Q96BY5	Gene names	NOV, CCN3, IGFBP9, NOVH
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

PTN23_MOUSE
θ value	5.27518 (rank : 192)	NC score	-0.000595 (rank : 263)
Query Neighborhood Hits	227	Target Neighborhood Hits	726	Shared Neighborhood Hits	10
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

RSPO2_HUMAN
θ value	5.27518 (rank : 193)	NC score	0.051284 (rank : 174)
Query Neighborhood Hits	227	Target Neighborhood Hits	90	Shared Neighborhood Hits	32
SwissProt Accessions	Q6UXX9, Q4G0U4, Q8N6X6	Gene names	RSPO2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (hRspo2).

STA13_MOUSE
θ value	5.27518 (rank : 194)	NC score	0.002334 (rank : 258)
Query Neighborhood Hits	227	Target Neighborhood Hits	89	Shared Neighborhood Hits	3
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

WISP1_HUMAN
θ value	5.27518 (rank : 195)	NC score	0.116561 (rank : 123)
Query Neighborhood Hits	227	Target Neighborhood Hits	121	Shared Neighborhood Hits	57
SwissProt Accessions	O95388, Q9HCS3	Gene names	WISP1, CCN4
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (Wnt-1- induced secreted protein).

ZAR1_HUMAN
θ value	5.27518 (rank : 196)	NC score	0.012380 (rank : 235)
Query Neighborhood Hits	227	Target Neighborhood Hits	163	Shared Neighborhood Hits	5
SwissProt Accessions	Q86SH2	Gene names	ZAR1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

B3AT_MOUSE
θ value	6.88961 (rank : 197)	NC score	0.002069 (rank : 259)
Query Neighborhood Hits	227	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	P04919	Gene names	Slc4a1, Ae1
Domain Architecture
Description	Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Solute carrier family 4 member 1) (MEB3) (CD233 antigen).

DLL1_HUMAN
θ value	6.88961 (rank : 198)	NC score	0.040436 (rank : 208)
Query Neighborhood Hits	227	Target Neighborhood Hits	455	Shared Neighborhood Hits	85
SwissProt Accessions	O00548, Q9NU41, Q9UJV2	Gene names	DLL1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1) (H-Delta-1).

EDIL3_MOUSE
θ value	6.88961 (rank : 199)	NC score	0.015146 (rank : 231)
Query Neighborhood Hits	227	Target Neighborhood Hits	317	Shared Neighborhood Hits	39
SwissProt Accessions	O35474, O35475	Gene names	Edil3, Del1
Domain Architecture
Description	EGF-like repeat and discoidin I-like domain-containing protein 3 precursor (EGF-like repeats and discoidin I-like domains protein 3) (Developmentally-regulated endothelial cell locus 1 protein) (Integrin-binding protein DEL1).

FIZ1_MOUSE
θ value	6.88961 (rank : 200)	NC score	-0.006024 (rank : 268)
Query Neighborhood Hits	227	Target Neighborhood Hits	715	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WTJ4, Q91W14, Q9CTG3	Gene names	Fiz1
Domain Architecture	No domain graphic available
Description	Flt3-interacting zinc finger protein 1.

KR10C_HUMAN
θ value	6.88961 (rank : 201)	NC score	0.054928 (rank : 166)
Query Neighborhood Hits	227	Target Neighborhood Hits	219	Shared Neighborhood Hits	55
SwissProt Accessions	P60413	Gene names	KRTAP10-12, KAP10.12, KAP18-12, KRTAP10.12, KRTAP18-12, KRTAP18.12
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-12 (Keratin-associated protein 10.12) (High sulfur keratin-associated protein 10.12) (Keratin-associated protein 18-12) (Keratin-associated protein 18.12).

MMP16_HUMAN
θ value	6.88961 (rank : 202)	NC score	0.041381 (rank : 205)
Query Neighborhood Hits	227	Target Neighborhood Hits	68	Shared Neighborhood Hits	37
SwissProt Accessions	P51512, Q14824, Q52H48	Gene names	MMP16, MMPX2
Domain Architecture
Description	Matrix metalloproteinase-16 precursor (EC 3.4.24.-) (MMP-16) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP) (MMP- X2).

MMP16_MOUSE
θ value	6.88961 (rank : 203)	NC score	0.041355 (rank : 206)
Query Neighborhood Hits	227	Target Neighborhood Hits	72	Shared Neighborhood Hits	37
SwissProt Accessions	Q9WTR0, Q9ERT6	Gene names	Mmp16
Domain Architecture
Description	Matrix metalloproteinase-16 precursor (EC 3.4.24.-) (MMP-16) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP).

MMP17_HUMAN
θ value	6.88961 (rank : 204)	NC score	0.038186 (rank : 213)
Query Neighborhood Hits	227	Target Neighborhood Hits	56	Shared Neighborhood Hits	33
SwissProt Accessions	Q9ULZ9, Q14850	Gene names	MMP17, MT4MMP
Domain Architecture
Description	Matrix metalloproteinase-17 precursor (EC 3.4.24.-) (MMP-17) (Membrane-type matrix metalloproteinase 4) (MT-MMP 4) (Membrane-type-4 matrix metalloproteinase) (MT4-MMP).

MMP20_MOUSE
θ value	6.88961 (rank : 205)	NC score	0.041782 (rank : 203)
Query Neighborhood Hits	227	Target Neighborhood Hits	56	Shared Neighborhood Hits	34
SwissProt Accessions	P57748	Gene names	Mmp20
Domain Architecture
Description	Matrix metalloproteinase-20 precursor (EC 3.4.24.-) (MMP-20) (Enamel metalloproteinase) (Enamelysin).

MMP21_MOUSE
θ value	6.88961 (rank : 206)	NC score	0.042891 (rank : 197)
Query Neighborhood Hits	227	Target Neighborhood Hits	59	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K3F2	Gene names	Mmp21
Domain Architecture	No domain graphic available
Description	Matrix metalloproteinase-21 precursor (EC 3.4.24.-) (MMP-21).

MMP3_HUMAN
θ value	6.88961 (rank : 207)	NC score	0.038761 (rank : 212)
Query Neighborhood Hits	227	Target Neighborhood Hits	50	Shared Neighborhood Hits	31
SwissProt Accessions	P08254, Q3B7S0	Gene names	MMP3, STMY1
Domain Architecture
Description	Stromelysin-1 precursor (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1) (SL-1).

PCMD2_HUMAN
θ value	6.88961 (rank : 208)	NC score	0.005069 (rank : 247)
Query Neighborhood Hits	227	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NV79, Q8IW60, Q9H4K2	Gene names	PCMTD2, C20orf36
Domain Architecture
Description	Protein-L-isoaspartate O-methyltransferase domain-containing protein 2.

RSPO2_MOUSE
θ value	6.88961 (rank : 209)	NC score	0.044190 (rank : 188)
Query Neighborhood Hits	227	Target Neighborhood Hits	88	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BFU0, Q7TPX3	Gene names	Rspo2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (Cysteine-rich and single thrombospondin domain-containing protein 2) (Cristin-2) (mCristin-2).

S35B1_HUMAN
θ value	6.88961 (rank : 210)	NC score	0.005576 (rank : 246)
Query Neighborhood Hits	227	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	P78383, Q96EW7	Gene names	SLC35B1, UGTREL1
Domain Architecture	No domain graphic available
Description	Solute carrier family 35 member B1 (UDP-galactose transporter-related protein 1) (UGTrel1) (hUGTrel1).

SPR2F_HUMAN
θ value	6.88961 (rank : 211)	NC score	0.024510 (rank : 224)
Query Neighborhood Hits	227	Target Neighborhood Hits	33	Shared Neighborhood Hits	5
SwissProt Accessions	Q96RM1	Gene names	SPRR2F
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2F (SPR-2F).

VWF_HUMAN
θ value	6.88961 (rank : 212)	NC score	0.043739 (rank : 192)
Query Neighborhood Hits	227	Target Neighborhood Hits	396	Shared Neighborhood Hits	65
SwissProt Accessions	P04275	Gene names	VWF, F8VWF
Domain Architecture
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

WNT2_MOUSE
θ value	6.88961 (rank : 213)	NC score	0.002602 (rank : 257)
Query Neighborhood Hits	227	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	P21552	Gene names	Wnt2, Irp, Wnt-2
Domain Architecture	No domain graphic available
Description	Protein Wnt-2 precursor (IRP protein) (INT-1-related protein).

APOA_HUMAN
θ value	8.99809 (rank : 214)	NC score	0.003924 (rank : 255)
Query Neighborhood Hits	227	Target Neighborhood Hits	221	Shared Neighborhood Hits	8
SwissProt Accessions	P08519	Gene names	LPA
Domain Architecture
Description	Apolipoprotein(a) precursor (EC 3.4.21.-) (Apo(a)) (Lp(a)).

CELR2_HUMAN
θ value	8.99809 (rank : 215)	NC score	0.028279 (rank : 218)
Query Neighborhood Hits	227	Target Neighborhood Hits	657	Shared Neighborhood Hits	62
SwissProt Accessions	Q9HCU4, Q92566	Gene names	CELSR2, CDHF10, EGFL2, KIAA0279, MEGF3
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 2 precursor (Epidermal growth factor-like 2) (Multiple epidermal growth factor-like domains 3) (Flamingo 1).

CO039_HUMAN
θ value	8.99809 (rank : 216)	NC score	0.004787 (rank : 249)
Query Neighborhood Hits	227	Target Neighborhood Hits	264	Shared Neighborhood Hits	10
SwissProt Accessions	Q6ZRI6, Q71JB1, Q7L3S0, Q8N3F2, Q96FB6, Q9NTU5	Gene names	C15orf39
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39.

EDIL3_HUMAN
θ value	8.99809 (rank : 217)	NC score	0.015469 (rank : 230)
Query Neighborhood Hits	227	Target Neighborhood Hits	292	Shared Neighborhood Hits	36
SwissProt Accessions	O43854, O43855	Gene names	EDIL3, DEL1
Domain Architecture
Description	EGF-like repeat and discoidin I-like domain-containing protein 3 precursor (EGF-like repeats and discoidin I-like domains protein 3) (Developmentally-regulated endothelial cell locus 1 protein) (Integrin-binding protein DEL1).

FBN2_HUMAN
θ value	8.99809 (rank : 218)	NC score	0.046011 (rank : 184)
Query Neighborhood Hits	227	Target Neighborhood Hits	560	Shared Neighborhood Hits	93
SwissProt Accessions	P35556	Gene names	FBN2
Domain Architecture
Description	Fibrillin-2 precursor.

GLI1_HUMAN
θ value	8.99809 (rank : 219)	NC score	-0.005647 (rank : 267)
Query Neighborhood Hits	227	Target Neighborhood Hits	828	Shared Neighborhood Hits	12
SwissProt Accessions	P08151, Q8TDN9	Gene names	GLI1, GLI
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI).

KRA94_HUMAN
θ value	8.99809 (rank : 220)	NC score	0.042519 (rank : 200)
Query Neighborhood Hits	227	Target Neighborhood Hits	204	Shared Neighborhood Hits	46
SwissProt Accessions	Q9BYQ2	Gene names	KRTAP9-4, KAP9.4, KRTAP9.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-4 (Keratin-associated protein 9.4) (Ultrahigh sulfur keratin-associated protein 9.4).

LAG3_HUMAN
θ value	8.99809 (rank : 221)	NC score	0.010902 (rank : 239)
Query Neighborhood Hits	227	Target Neighborhood Hits	129	Shared Neighborhood Hits	4
SwissProt Accessions	P18627	Gene names	LAG3, FDC
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (FDC protein) (CD223 antigen).

LYAM2_HUMAN
θ value	8.99809 (rank : 222)	NC score	0.027019 (rank : 219)
Query Neighborhood Hits	227	Target Neighborhood Hits	394	Shared Neighborhood Hits	41
SwissProt Accessions	P16581, P16111	Gene names	SELE, ELAM1
Domain Architecture
Description	E-selectin precursor (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD62E antigen).

MAP4_MOUSE
θ value	8.99809 (rank : 223)	NC score	0.002006 (rank : 260)
Query Neighborhood Hits	227	Target Neighborhood Hits	409	Shared Neighborhood Hits	9
SwissProt Accessions	P27546	Gene names	Map4, Mtap4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

MMP20_HUMAN
θ value	8.99809 (rank : 224)	NC score	0.040965 (rank : 207)
Query Neighborhood Hits	227	Target Neighborhood Hits	56	Shared Neighborhood Hits	34
SwissProt Accessions	O60882, Q6DKT9	Gene names	MMP20
Domain Architecture
Description	Matrix metalloproteinase-20 precursor (EC 3.4.24.-) (MMP-20) (Enamel metalloproteinase) (Enamelysin).

PERT_MOUSE
θ value	8.99809 (rank : 225)	NC score	0.011845 (rank : 237)
Query Neighborhood Hits	227	Target Neighborhood Hits	221	Shared Neighborhood Hits	24
SwissProt Accessions	P35419, Q8C8B1	Gene names	Tpo
Domain Architecture
Description	Thyroid peroxidase precursor (EC 1.11.1.8) (TPO).

TRI47_HUMAN
θ value	8.99809 (rank : 226)	NC score	0.002851 (rank : 256)
Query Neighborhood Hits	227	Target Neighborhood Hits	286	Shared Neighborhood Hits	6
SwissProt Accessions	Q96LD4, Q96GU5, Q9BRN7	Gene names	TRIM47, GOA, RNF100
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47 (Gene overexpressed in astrocytoma protein) (RING finger protein 100).

UBXD1_MOUSE
θ value	8.99809 (rank : 227)	NC score	0.004953 (rank : 248)
Query Neighborhood Hits	227	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q99PL6, Q91W79	Gene names	Ubxd1, Ubxdc2
Domain Architecture
Description	UBX domain-containing protein 1.

ADA11_HUMAN
θ value	θ > 10 (rank : 228)	NC score	0.268672 (rank : 108)
Query Neighborhood Hits	227	Target Neighborhood Hits	259	Shared Neighborhood Hits	81
SwissProt Accessions	O75078, Q14808, Q14809, Q14810	Gene names	ADAM11, MDC
Domain Architecture
Description	ADAM 11 precursor (A disintegrin and metalloproteinase domain 11) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein) (MDC).

ADA11_MOUSE
θ value	θ > 10 (rank : 229)	NC score	0.293167 (rank : 106)
Query Neighborhood Hits	227	Target Neighborhood Hits	263	Shared Neighborhood Hits	81
SwissProt Accessions	Q9R1V4	Gene names	Adam11, Mdc
Domain Architecture
Description	ADAM 11 precursor (A disintegrin and metalloproteinase domain 11) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein) (MDC).

ADA18_HUMAN
θ value	θ > 10 (rank : 230)	NC score	0.220457 (rank : 118)
Query Neighborhood Hits	227	Target Neighborhood Hits	184	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Y3Q7, Q6UXJ9	Gene names	ADAM18, TMDC3
Domain Architecture
Description	ADAM 18 precursor (A disintegrin and metalloproteinase domain 18) (Transmembrane metalloproteinase-like, disintegrin-like, and cysteine- rich protein III) (tMDC III).

ADA18_MOUSE
θ value	θ > 10 (rank : 231)	NC score	0.245506 (rank : 116)
Query Neighborhood Hits	227	Target Neighborhood Hits	227	Shared Neighborhood Hits	87
SwissProt Accessions	Q9R157, Q60621	Gene names	Adam18, Adam27, Dtgn3, Tmdc3
Domain Architecture
Description	ADAM 18 precursor (A disintegrin and metalloproteinase domain 18) (Transmembrane metalloproteinase-like, disintegrin-like, and cysteine- rich protein III) (tMDC III) (ADAM 27).

ADA23_HUMAN
θ value	θ > 10 (rank : 232)	NC score	0.301829 (rank : 104)
Query Neighborhood Hits	227	Target Neighborhood Hits	235	Shared Neighborhood Hits	80
SwissProt Accessions	O75077	Gene names	ADAM23, MDC3
Domain Architecture	No domain graphic available
Description	ADAM 23 precursor (A disintegrin and metalloproteinase domain 23) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3) (MDC-3).

ADA23_MOUSE
θ value	θ > 10 (rank : 233)	NC score	0.309138 (rank : 101)
Query Neighborhood Hits	227	Target Neighborhood Hits	245	Shared Neighborhood Hits	82
SwissProt Accessions	Q9R1V7, Q6QDY9, Q6QDZ0, Q8CC33	Gene names	Adam23, Mdc3
Domain Architecture	No domain graphic available
Description	ADAM 23 precursor (A disintegrin and metalloproteinase domain 23) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3) (MDC-3).

ADAM2_HUMAN
θ value	θ > 10 (rank : 234)	NC score	0.231261 (rank : 117)
Query Neighborhood Hits	227	Target Neighborhood Hits	175	Shared Neighborhood Hits	74
SwissProt Accessions	Q99965, P78326, Q9UQQ8	Gene names	ADAM2, FTNB
Domain Architecture
Description	ADAM 2 precursor (A disintegrin and metalloproteinase domain 2) (Fertilin subunit beta) (PH-30) (PH30).

ADEC1_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.381443 (rank : 82)
Query Neighborhood Hits	227	Target Neighborhood Hits	80	Shared Neighborhood Hits	62
SwissProt Accessions	O15204	Gene names	ADAMDEC1
Domain Architecture	No domain graphic available
Description	ADAM DEC1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain-like protein decysin 1) (ADAM-like protein decysin 1).

ADEC1_MOUSE
θ value	θ > 10 (rank : 236)	NC score	0.330444 (rank : 92)
Query Neighborhood Hits	227	Target Neighborhood Hits	85	Shared Neighborhood Hits	63
SwissProt Accessions	Q9R0X2	Gene names	Adamdec1
Domain Architecture	No domain graphic available
Description	ADAM DEC1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain-like protein decysin 1) (ADAM-like protein decysin 1).

CO9_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.073344 (rank : 143)
Query Neighborhood Hits	227	Target Neighborhood Hits	147	Shared Neighborhood Hits	23
SwissProt Accessions	P02748	Gene names	C9
Domain Architecture
Description	Complement component C9 precursor [Contains: Complement component C9a; Complement component C9b].

CO9_MOUSE
θ value	θ > 10 (rank : 238)	NC score	0.082273 (rank : 134)
Query Neighborhood Hits	227	Target Neighborhood Hits	153	Shared Neighborhood Hits	28
SwissProt Accessions	P06683, Q91XA7	Gene names	C9
Domain Architecture
Description	Complement component C9 precursor.

COMP_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.064424 (rank : 152)
Query Neighborhood Hits	227	Target Neighborhood Hits	258	Shared Neighborhood Hits	33
SwissProt Accessions	P49747, O14592, Q16388, Q16389, Q8N4T2	Gene names	COMP
Domain Architecture
Description	Cartilage oligomeric matrix protein precursor (COMP).

COMP_MOUSE
θ value	θ > 10 (rank : 240)	NC score	0.064454 (rank : 151)
Query Neighborhood Hits	227	Target Neighborhood Hits	290	Shared Neighborhood Hits	35
SwissProt Accessions	Q9R0G6	Gene names	Comp
Domain Architecture
Description	Cartilage oligomeric matrix protein precursor (COMP).

CRIM1_HUMAN
θ value	θ > 10 (rank : 241)	NC score	0.057128 (rank : 164)
Query Neighborhood Hits	227	Target Neighborhood Hits	362	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

CTGF_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.078062 (rank : 140)
Query Neighborhood Hits	227	Target Neighborhood Hits	128	Shared Neighborhood Hits	53
SwissProt Accessions	P29279, Q96QX2	Gene names	CTGF, CCN2, HCS24
Domain Architecture
Description	Connective tissue growth factor precursor (Hypertrophic chondrocyte- specific protein 24).

CTGF_MOUSE
θ value	θ > 10 (rank : 243)	NC score	0.081978 (rank : 135)
Query Neighborhood Hits	227	Target Neighborhood Hits	124	Shared Neighborhood Hits	53
SwissProt Accessions	P29268, Q922U0	Gene names	Ctgf, Ccn2, Fisp-12, Fisp12, Hcs24
Domain Architecture
Description	Connective tissue growth factor precursor (Protein FISP-12) (Hypertrophic chondrocyte-specific protein 24).

CYR61_HUMAN
θ value	θ > 10 (rank : 244)	NC score	0.103041 (rank : 125)
Query Neighborhood Hits	227	Target Neighborhood Hits	159	Shared Neighborhood Hits	66
SwissProt Accessions	O00622, O14934, O43775, Q9BZL7	Gene names	CYR61, CCN1, GIG1, IGFBP10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (Protein GIG1).

CYR61_MOUSE
θ value	θ > 10 (rank : 245)	NC score	0.088746 (rank : 131)
Query Neighborhood Hits	227	Target Neighborhood Hits	156	Shared Neighborhood Hits	57
SwissProt Accessions	P18406	Gene names	Cyr61, Ccn1, Igfbp10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (3CH61).

KR101_HUMAN
θ value	θ > 10 (rank : 246)	NC score	0.064456 (rank : 150)
Query Neighborhood Hits	227	Target Neighborhood Hits	261	Shared Neighborhood Hits	65
SwissProt Accessions	P60331	Gene names	KRTAP10-1, KAP10.1, KAP18-1, KRTAP10.1, KRTAP18-1, KRTAP18.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-1 (Keratin-associated protein 10.1) (High sulfur keratin-associated protein 10.1) (Keratin-associated protein 18-1) (Keratin-associated protein 18.1).

KR109_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.063413 (rank : 154)
Query Neighborhood Hits	227	Target Neighborhood Hits	226	Shared Neighborhood Hits	48
SwissProt Accessions	P60411, Q70LJ1	Gene names	KRTAP10-9, KAP10.9, KAP18-9, KRTAP10.9, KRTAP18-9, KRTAP18.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-9 (Keratin-associated protein 10.9) (High sulfur keratin-associated protein 10.9) (Keratin-associated protein 18-9) (Keratin-associated protein 18.9).

KR10B_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.054596 (rank : 167)
Query Neighborhood Hits	227	Target Neighborhood Hits	269	Shared Neighborhood Hits	56
SwissProt Accessions	P60412	Gene names	KRTAP10-11, KAP10.11, KAP18-11, KRTAP10.11, KRTAP18-11, KRTAP18.11
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-11 (Keratin-associated protein 10.11) (High sulfur keratin-associated protein 10.11) (Keratin-associated protein 18-11) (Keratin-associated protein 18.11).

KRA51_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.064562 (rank : 149)
Query Neighborhood Hits	227	Target Neighborhood Hits	288	Shared Neighborhood Hits	73
SwissProt Accessions	Q6L8H4	Gene names	KRTAP5-1, KAP5.1, KRTAP5.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-1 (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1).

KRA53_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.052513 (rank : 172)
Query Neighborhood Hits	227	Target Neighborhood Hits	331	Shared Neighborhood Hits	71
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

KRA92_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.065043 (rank : 148)
Query Neighborhood Hits	227	Target Neighborhood Hits	198	Shared Neighborhood Hits	44
SwissProt Accessions	Q9BYQ4	Gene names	KRTAP9-2, KAP9.2, KRTAP9.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-2 (Keratin-associated protein 9.2) (Ultrahigh sulfur keratin-associated protein 9.2).

KRA93_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.061646 (rank : 156)
Query Neighborhood Hits	227	Target Neighborhood Hits	203	Shared Neighborhood Hits	52
SwissProt Accessions	Q9BYQ3	Gene names	KRTAP9-3, KAP9.3, KRTAP9.3
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-3 (Keratin-associated protein 9.3) (Ultrahigh sulfur keratin-associated protein 9.3).

NFX1_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.053626 (rank : 168)
Query Neighborhood Hits	227	Target Neighborhood Hits	405	Shared Neighborhood Hits	56
SwissProt Accessions	Q12986	Gene names	NFX1
Domain Architecture
Description	Transcriptional repressor NF-X1 (EC 6.3.2.-) (Nuclear transcription factor, X box-binding, 1).

RSPO1_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.081052 (rank : 137)
Query Neighborhood Hits	227	Target Neighborhood Hits	101	Shared Neighborhood Hits	46
SwissProt Accessions	Q2MKA7, Q5T0F2, Q8N7L5	Gene names	RSPO1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (hRspo1).

RSPO1_MOUSE
θ value	θ > 10 (rank : 255)	NC score	0.068144 (rank : 145)
Query Neighborhood Hits	227	Target Neighborhood Hits	85	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Z132, Q3V1S3	Gene names	Rspo1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (Cysteine-rich and single thrombospondin domain-containing protein 3) (Cristin-3) (mCristin-3).

RSPO3_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.057897 (rank : 163)
Query Neighborhood Hits	227	Target Neighborhood Hits	128	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BXY4, Q5VTV4, Q96K87	Gene names	RSPO3, PWTSR, THSD2
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2) (Protein with TSP type-1 repeat) (hPWTSR).

RSPO3_MOUSE
θ value	θ > 10 (rank : 257)	NC score	0.052734 (rank : 170)
Query Neighborhood Hits	227	Target Neighborhood Hits	120	Shared Neighborhood Hits	36
SwissProt Accessions	Q2TJ95, Q3SYI9, Q5R2V4, Q8BVW2, Q9CSB2	Gene names	Rspo3
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (Cysteine-rich and single thrombospondin domain-containing protein 1) (Cristin-1) (Nucleopondin) (Cabriolet).

RSPO4_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.061337 (rank : 158)
Query Neighborhood Hits	227	Target Neighborhood Hits	110	Shared Neighborhood Hits	35
SwissProt Accessions	Q2I0M5, Q9UGB2	Gene names	RSPO4, C20orf182
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (hRspo4).

RSPO4_MOUSE
θ value	θ > 10 (rank : 259)	NC score	0.083490 (rank : 133)
Query Neighborhood Hits	227	Target Neighborhood Hits	110	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BJ73	Gene names	Rspo4
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (Cysteine-rich and single thrombospondin domain-containing protein 4) (Cristin-4) (mCristin-4).

SPON2_HUMAN
θ value	θ > 10 (rank : 260)	NC score	0.075342 (rank : 141)
Query Neighborhood Hits	227	Target Neighborhood Hits	53	Shared Neighborhood Hits	33
SwissProt Accessions	Q9BUD6, Q9ULW1	Gene names	SPON2, DIL1
Domain Architecture	No domain graphic available
Description	Spondin-2 precursor (Mindin) (Differentially expressed in cancerous and non-cancerous lung cells 1) (DIL-1).

SPON2_MOUSE
θ value	θ > 10 (rank : 261)	NC score	0.062341 (rank : 155)
Query Neighborhood Hits	227	Target Neighborhood Hits	42	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BMS2, Q6SJD8	Gene names	Spon2
Domain Architecture	No domain graphic available
Description	Spondin-2 precursor (Mindin).

TENX_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.052363 (rank : 173)
Query Neighborhood Hits	227	Target Neighborhood Hits	789	Shared Neighborhood Hits	99
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

TSP3_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.065060 (rank : 147)
Query Neighborhood Hits	227	Target Neighborhood Hits	250	Shared Neighborhood Hits	30
SwissProt Accessions	P49746, Q8WV34	Gene names	THBS3, TSP3
Domain Architecture
Description	Thrombospondin-3 precursor.

TSP3_MOUSE
θ value	θ > 10 (rank : 264)	NC score	0.064024 (rank : 153)
Query Neighborhood Hits	227	Target Neighborhood Hits	247	Shared Neighborhood Hits	26
SwissProt Accessions	Q05895, Q6LCE0	Gene names	Thbs3, Tsp3
Domain Architecture
Description	Thrombospondin-3 precursor.

TSP4_HUMAN
θ value	θ > 10 (rank : 265)	NC score	0.061548 (rank : 157)
Query Neighborhood Hits	227	Target Neighborhood Hits	277	Shared Neighborhood Hits	31
SwissProt Accessions	P35443, Q86TG2	Gene names	THBS4, TSP4
Domain Architecture
Description	Thrombospondin-4 precursor.

TSP4_MOUSE
θ value	θ > 10 (rank : 266)	NC score	0.060844 (rank : 159)
Query Neighborhood Hits	227	Target Neighborhood Hits	276	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Z1T2, Q9QYS3, Q9WUE0	Gene names	Thbs4, Tsp4
Domain Architecture
Description	Thrombospondin-4 precursor.

WISP1_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.122912 (rank : 122)
Query Neighborhood Hits	227	Target Neighborhood Hits	123	Shared Neighborhood Hits	53
SwissProt Accessions	O54775, Q80ZL1	Gene names	Wisp1, Ccn4, Elm1
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (ELM-1).

WISP3_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.097738 (rank : 126)
Query Neighborhood Hits	227	Target Neighborhood Hits	87	Shared Neighborhood Hits	40
SwissProt Accessions	O95389, Q6UXH6	Gene names	WISP3, CCN6
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 3 precursor (WISP-3).

ZAN_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.065924 (rank : 146)
Query Neighborhood Hits	227	Target Neighborhood Hits	808	Shared Neighborhood Hits	108
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

Hits sorted by NC score

ATS13_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	227	Target Neighborhood Hits	227	Shared Neighborhood Hits	227
SwissProt Accessions	Q769J6, Q76LW1	Gene names	Adamts13
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

ATS13_HUMAN
NC score	0.989497 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	227	Target Neighborhood Hits	238	Shared Neighborhood Hits	152
SwissProt Accessions	Q76LX8, Q6UY16, Q710F6, Q711T8, Q96L37, Q9H0G3	Gene names	ADAMTS13, C9orf8
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

ATS2_HUMAN
NC score	0.944861 (rank : 3)	θ value	2.63489e-92 (rank : 13)
Query Neighborhood Hits	227	Target Neighborhood Hits	179	Shared Neighborhood Hits	128
SwissProt Accessions	O95450	Gene names	ADAMTS2, PCINP, PCPNI
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

ATS2_MOUSE
NC score	0.944025 (rank : 4)	θ value	2.15548e-94 (rank : 11)
Query Neighborhood Hits	227	Target Neighborhood Hits	179	Shared Neighborhood Hits	127
SwissProt Accessions	Q8C9W3	Gene names	Adamts2
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

ATS18_MOUSE
NC score	0.943413 (rank : 5)	θ value	4.77967e-110 (rank : 3)
Query Neighborhood Hits	227	Target Neighborhood Hits	163	Shared Neighborhood Hits	124
SwissProt Accessions	Q4VC17, Q8BZD1	Gene names	Adamts18
Domain Architecture	No domain graphic available
Description	ADAMTS-18 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18).

ATS3_HUMAN
NC score	0.940545 (rank : 6)	θ value	3.67668e-94 (rank : 12)
Query Neighborhood Hits	227	Target Neighborhood Hits	179	Shared Neighborhood Hits	134
SwissProt Accessions	O15072, Q9BXZ8	Gene names	ADAMTS3, KIAA0366
Domain Architecture
Description	ADAMTS-3 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 3) (ADAM-TS 3) (ADAM-TS3) (Procollagen II amino propeptide-processing enzyme) (Procollagen II N-proteinase) (PC II-NP).

ATS18_HUMAN
NC score	0.939997 (rank : 7)	θ value	1.81628e-109 (rank : 5)
Query Neighborhood Hits	227	Target Neighborhood Hits	169	Shared Neighborhood Hits	125
SwissProt Accessions	Q8TE60, Q6P4R5, Q6ZWJ9	Gene names	ADAMTS18, ADAMTS21
Domain Architecture
Description	ADAMTS-18 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18).

ATS17_HUMAN
NC score	0.938792 (rank : 8)	θ value	3.56116e-89 (rank : 14)
Query Neighborhood Hits	227	Target Neighborhood Hits	194	Shared Neighborhood Hits	139
SwissProt Accessions	Q8TE56	Gene names	ADAMTS17
Domain Architecture
Description	ADAMTS-17 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 17) (ADAM-TS 17) (ADAM-TS17).

ATS15_HUMAN
NC score	0.936208 (rank : 9)	θ value	6.08852e-81 (rank : 18)
Query Neighborhood Hits	227	Target Neighborhood Hits	151	Shared Neighborhood Hits	117
SwissProt Accessions	Q8TE58	Gene names	ADAMTS15
Domain Architecture
Description	ADAMTS-15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 15) (ADAM-TS 15) (ADAM-TS15).

ATS8_HUMAN
NC score	0.936136 (rank : 10)	θ value	1.96316e-71 (rank : 22)
Query Neighborhood Hits	227	Target Neighborhood Hits	145	Shared Neighborhood Hits	112
SwissProt Accessions	Q9UP79, Q9NZS0	Gene names	ADAMTS8, METH2
Domain Architecture
Description	ADAMTS-8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2) (METH- 8).

ATS4_MOUSE
NC score	0.935371 (rank : 11)	θ value	2.17557e-62 (rank : 27)
Query Neighborhood Hits	227	Target Neighborhood Hits	145	Shared Neighborhood Hits	116
SwissProt Accessions	Q8BNJ2, Q8K384	Gene names	Adamts4
Domain Architecture	No domain graphic available
Description	ADAMTS-4 precursor (EC 3.4.24.82) (A disintegrin and metalloproteinase with thrombospondin motifs 4) (ADAM-TS 4) (ADAM-TS4) (Aggrecanase-1).

ATS8_MOUSE
NC score	0.935112 (rank : 12)	θ value	2.32439e-64 (rank : 25)
Query Neighborhood Hits	227	Target Neighborhood Hits	139	Shared Neighborhood Hits	114
SwissProt Accessions	P57110	Gene names	Adamts8
Domain Architecture
Description	ADAMTS-8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2).

ATS16_MOUSE
NC score	0.934826 (rank : 13)	θ value	2.90646e-99 (rank : 9)
Query Neighborhood Hits	227	Target Neighborhood Hits	179	Shared Neighborhood Hits	126
SwissProt Accessions	Q69Z28, Q8K206	Gene names	Adamts16, Kiaa2029
Domain Architecture	No domain graphic available
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

ATS4_HUMAN
NC score	0.934461 (rank : 14)	θ value	5.7252e-63 (rank : 26)
Query Neighborhood Hits	227	Target Neighborhood Hits	138	Shared Neighborhood Hits	110
SwissProt Accessions	O75173, Q5VTW2, Q6P4Q8, Q6UWA8, Q9UN83	Gene names	ADAMTS4, KIAA0688
Domain Architecture
Description	ADAMTS-4 precursor (EC 3.4.24.82) (A disintegrin and metalloproteinase with thrombospondin motifs 4) (ADAM-TS 4) (ADAM-TS4) (Aggrecanase-1) (ADMP-1).

ATS16_HUMAN
NC score	0.934402 (rank : 15)	θ value	2.71407e-105 (rank : 7)
Query Neighborhood Hits	227	Target Neighborhood Hits	208	Shared Neighborhood Hits	128
SwissProt Accessions	Q8TE57, Q8IVE2	Gene names	ADAMTS16, KIAA2029
Domain Architecture
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

ATS1_HUMAN
NC score	0.933571 (rank : 16)	θ value	1.82896e-85 (rank : 17)
Query Neighborhood Hits	227	Target Neighborhood Hits	159	Shared Neighborhood Hits	116
SwissProt Accessions	Q9UHI8, Q9NSJ8, Q9P2K0, Q9UH83, Q9UP80	Gene names	ADAMTS1, KIAA1346, METH1
Domain Architecture
Description	ADAMTS-1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 1) (ADAM-TS 1) (ADAM-TS1) (METH-1).

ATS12_MOUSE
NC score	0.933344 (rank : 17)	θ value	2.72037e-97 (rank : 10)
Query Neighborhood Hits	227	Target Neighborhood Hits	220	Shared Neighborhood Hits	124
SwissProt Accessions	Q811B3, Q8BK92, Q8BKY1	Gene names	Adamts12
Domain Architecture	No domain graphic available
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

ATS1_MOUSE
NC score	0.932613 (rank : 18)	θ value	3.0147e-88 (rank : 16)
Query Neighborhood Hits	227	Target Neighborhood Hits	158	Shared Neighborhood Hits	118
SwissProt Accessions	P97857, O54768	Gene names	Adamts1
Domain Architecture
Description	ADAMTS-1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 1) (ADAM-TS 1) (ADAM-TS1).

ATS12_HUMAN
NC score	0.932223 (rank : 19)	θ value	5.85632e-100 (rank : 8)
Query Neighborhood Hits	227	Target Neighborhood Hits	251	Shared Neighborhood Hits	123
SwissProt Accessions	P58397, Q6UWL3	Gene names	ADAMTS12
Domain Architecture
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

ATS9_HUMAN
NC score	0.930675 (rank : 20)	θ value	1.59114e-105 (rank : 6)
Query Neighborhood Hits	227	Target Neighborhood Hits	219	Shared Neighborhood Hits	130
SwissProt Accessions	Q9P2N4, Q9NR29	Gene names	ADAMTS9, KIAA1312
Domain Architecture
Description	ADAMTS-9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 9) (ADAM-TS 9) (ADAM-TS9).

ATS14_HUMAN
NC score	0.928261 (rank : 21)	θ value	1.35324e-88 (rank : 15)
Query Neighborhood Hits	227	Target Neighborhood Hits	382	Shared Neighborhood Hits	124
SwissProt Accessions	Q8WXS8, Q8TE55, Q8TEY8	Gene names	ADAMTS14
Domain Architecture
Description	ADAMTS-14 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 14) (ADAM-TS 14) (ADAM-TS14).

ATS20_MOUSE
NC score	0.927488 (rank : 22)	θ value	1.39067e-109 (rank : 4)
Query Neighborhood Hits	227	Target Neighborhood Hits	225	Shared Neighborhood Hits	127
SwissProt Accessions	P59511	Gene names	Adamts20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

ATS19_MOUSE
NC score	0.925496 (rank : 23)	θ value	2.64714e-76 (rank : 20)
Query Neighborhood Hits	227	Target Neighborhood Hits	188	Shared Neighborhood Hits	126
SwissProt Accessions	P59509	Gene names	Adamts19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

ATS19_HUMAN
NC score	0.924919 (rank : 24)	θ value	8.22888e-78 (rank : 19)
Query Neighborhood Hits	227	Target Neighborhood Hits	203	Shared Neighborhood Hits	125
SwissProt Accessions	Q8TE59	Gene names	ADAMTS19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

ATS7_HUMAN
NC score	0.923272 (rank : 25)	θ value	4.67263e-73 (rank : 21)
Query Neighborhood Hits	227	Target Neighborhood Hits	169	Shared Neighborhood Hits	125
SwissProt Accessions	Q9UKP4	Gene names	ADAMTS7
Domain Architecture
Description	ADAMTS-7 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 7) (ADAM-TS 7) (ADAM-TS7).

ATS5_HUMAN
NC score	0.920013 (rank : 26)	θ value	1.71981e-67 (rank : 23)
Query Neighborhood Hits	227	Target Neighborhood Hits	141	Shared Neighborhood Hits	112
SwissProt Accessions	Q9UNA0, Q9UKP2	Gene names	ADAMTS5, ADAMTS11, ADMP2
Domain Architecture
Description	ADAMTS-5 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 5) (ADAM-TS 5) (ADAM-TS5) (Aggrecanase-2) (ADMP-2) (ADAM-TS 11).

ATS5_MOUSE
NC score	0.919684 (rank : 27)	θ value	1.71981e-67 (rank : 24)
Query Neighborhood Hits	227	Target Neighborhood Hits	147	Shared Neighborhood Hits	114
SwissProt Accessions	Q9R001	Gene names	Adamts5
Domain Architecture
Description	ADAMTS-5 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 5) (ADAM-TS 5) (ADAM-TS5) (Aggrecanase-2) (ADMP-2) (Implantin).

ATL1_HUMAN
NC score	0.916555 (rank : 28)	θ value	1.98146e-39 (rank : 30)
Query Neighborhood Hits	227	Target Neighborhood Hits	93	Shared Neighborhood Hits	80
SwissProt Accessions	Q8N6G6, Q5T708, Q96RW4, Q9BXY3	Gene names	ADAMTSL1, ADAMTSR1
Domain Architecture
Description	ADAMTS-like protein 1 precursor (ADAMTSL-1) (Punctin-1).

ATS6_HUMAN
NC score	0.916071 (rank : 29)	θ value	4.2656e-42 (rank : 29)
Query Neighborhood Hits	227	Target Neighborhood Hits	141	Shared Neighborhood Hits	116
SwissProt Accessions	Q9UKP5	Gene names	ADAMTS6
Domain Architecture
Description	ADAMTS-6 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 6) (ADAM-TS 6) (ADAM-TS6).

ATS20_HUMAN
NC score	0.915596 (rank : 30)	θ value	4.41421e-39 (rank : 31)
Query Neighborhood Hits	227	Target Neighborhood Hits	192	Shared Neighborhood Hits	128
SwissProt Accessions	P59510	Gene names	ADAMTS20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

ATL1_MOUSE
NC score	0.906472 (rank : 31)	θ value	1.33217e-27 (rank : 33)
Query Neighborhood Hits	227	Target Neighborhood Hits	80	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BLI0	Gene names	Adamtsl1
Domain Architecture
Description	ADAMTS-like protein 1 precursor (Punctin-1).

ATL5_HUMAN
NC score	0.905978 (rank : 32)	θ value	7.56453e-23 (rank : 35)
Query Neighborhood Hits	227	Target Neighborhood Hits	103	Shared Neighborhood Hits	75
SwissProt Accessions	Q6ZMM2, Q8IW95	Gene names	ADAMTSL5, THSD6
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 5 precursor (ADAMTSL-5) (Thrombospondin type-1 domain-containing protein 6).

ATL2_MOUSE
NC score	0.875688 (rank : 33)	θ value	1.73987e-27 (rank : 34)
Query Neighborhood Hits	227	Target Neighborhood Hits	137	Shared Neighborhood Hits	87
SwissProt Accessions	Q7TSK7, Q3U0C8	Gene names	Adamtsl2, Kiaa0605, Tcp1
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2) (TSP1-repeats-containing protein 1) (TCP-1).

ATL2_HUMAN
NC score	0.874776 (rank : 34)	θ value	1.02001e-27 (rank : 32)
Query Neighborhood Hits	227	Target Neighborhood Hits	125	Shared Neighborhood Hits	84
SwissProt Accessions	Q86TH1, O60345	Gene names	ADAMTSL2, KIAA0605
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2).

ATL3_HUMAN
NC score	0.780959 (rank : 35)	θ value	1.84173e-61 (rank : 28)
Query Neighborhood Hits	227	Target Neighborhood Hits	414	Shared Neighborhood Hits	91
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

PROP_HUMAN
NC score	0.659219 (rank : 36)	θ value	3.64472e-09 (rank : 52)
Query Neighborhood Hits	227	Target Neighborhood Hits	126	Shared Neighborhood Hits	81
SwissProt Accessions	P27918, O15134, O15135, O15136, O75826	Gene names	CFP, PFC
Domain Architecture
Description	Properdin precursor (Factor P).

PROP_MOUSE
NC score	0.651956 (rank : 37)	θ value	8.11959e-09 (rank : 54)
Query Neighborhood Hits	227	Target Neighborhood Hits	165	Shared Neighborhood Hits	87
SwissProt Accessions	P11680, Q3TB98, Q3U779	Gene names	Cfp, Pfc
Domain Architecture	No domain graphic available
Description	Properdin precursor (Factor P).

CI094_HUMAN
NC score	0.604558 (rank : 38)	θ value	2.43343e-21 (rank : 36)
Query Neighborhood Hits	227	Target Neighborhood Hits	310	Shared Neighborhood Hits	75
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

SPON1_HUMAN
NC score	0.594493 (rank : 39)	θ value	3.77169e-06 (rank : 69)
Query Neighborhood Hits	227	Target Neighborhood Hits	117	Shared Neighborhood Hits	85
SwissProt Accessions	Q9HCB6, O94862, Q8NCD7, Q8WUR5	Gene names	SPON1, KIAA0762, VSGP
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin) (Vascular smooth muscle cell growth- promoting factor).

SPON1_MOUSE
NC score	0.592649 (rank : 40)	θ value	6.43352e-06 (rank : 70)
Query Neighborhood Hits	227	Target Neighborhood Hits	123	Shared Neighborhood Hits	86
SwissProt Accessions	Q8VCC9, Q8K2Q8	Gene names	Spon1
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin).

THSD1_HUMAN
NC score	0.529559 (rank : 41)	θ value	7.1131e-05 (rank : 76)
Query Neighborhood Hits	227	Target Neighborhood Hits	136	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NS62, Q6P3U1, Q6UXZ2	Gene names	THSD1, TMTSP
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

TSP1_HUMAN
NC score	0.494613 (rank : 42)	θ value	7.09661e-13 (rank : 38)
Query Neighborhood Hits	227	Target Neighborhood Hits	389	Shared Neighborhood Hits	112
SwissProt Accessions	P07996, Q15667	Gene names	THBS1, TSP, TSP1
Domain Architecture
Description	Thrombospondin-1 precursor.

UNC5A_MOUSE
NC score	0.494505 (rank : 43)	θ value	1.80886e-08 (rank : 57)
Query Neighborhood Hits	227	Target Neighborhood Hits	203	Shared Neighborhood Hits	76
SwissProt Accessions	Q8K1S4, Q6PEF7, Q80T71	Gene names	Unc5a, Kiaa1976, Unc5h1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

TSP1_MOUSE
NC score	0.494177 (rank : 44)	θ value	7.09661e-13 (rank : 39)
Query Neighborhood Hits	227	Target Neighborhood Hits	396	Shared Neighborhood Hits	115
SwissProt Accessions	P35441	Gene names	Thbs1, Tsp1
Domain Architecture
Description	Thrombospondin-1 precursor.

THSD1_MOUSE
NC score	0.492391 (rank : 45)	θ value	0.00175202 (rank : 88)
Query Neighborhood Hits	227	Target Neighborhood Hits	153	Shared Neighborhood Hits	75
SwissProt Accessions	Q9JM61, Q8C7Q9	Gene names	Thsd1, Tmtsp
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

TSP2_MOUSE
NC score	0.491319 (rank : 46)	θ value	1.02475e-11 (rank : 42)
Query Neighborhood Hits	227	Target Neighborhood Hits	352	Shared Neighborhood Hits	113
SwissProt Accessions	Q03350	Gene names	Thbs2, Tsp2
Domain Architecture
Description	Thrombospondin-2 precursor.

TSP2_HUMAN
NC score	0.489543 (rank : 47)	θ value	9.26847e-13 (rank : 40)
Query Neighborhood Hits	227	Target Neighborhood Hits	359	Shared Neighborhood Hits	113
SwissProt Accessions	P35442	Gene names	THBS2, TSP2
Domain Architecture
Description	Thrombospondin-2 precursor.

UNC5B_MOUSE
NC score	0.484450 (rank : 48)	θ value	1.38499e-08 (rank : 56)
Query Neighborhood Hits	227	Target Neighborhood Hits	226	Shared Neighborhood Hits	75
SwissProt Accessions	Q8K1S3, Q3U4F2, Q6PFH0, Q80Y85, Q9D398	Gene names	Unc5b, Unc5h2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2).

UNC5B_HUMAN
NC score	0.481990 (rank : 49)	θ value	1.38499e-08 (rank : 55)
Query Neighborhood Hits	227	Target Neighborhood Hits	225	Shared Neighborhood Hits	75
SwissProt Accessions	Q8IZJ1, Q86SN3, Q8N1Y2, Q9H9F3	Gene names	UNC5B, P53RDL1, UNC5H2
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5B precursor (Unc-5 homolog B) (Unc-5 homolog 2) (p53-regulated receptor for death and life protein 1).

BAI2_HUMAN
NC score	0.481966 (rank : 50)	θ value	5.08577e-11 (rank : 44)
Query Neighborhood Hits	227	Target Neighborhood Hits	332	Shared Neighborhood Hits	91
SwissProt Accessions	O60241, Q5T6K0, Q8NGW8	Gene names	BAI2
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 2 precursor.

BAI1_MOUSE
NC score	0.480727 (rank : 51)	θ value	2.79066e-09 (rank : 50)
Query Neighborhood Hits	227	Target Neighborhood Hits	340	Shared Neighborhood Hits	92
SwissProt Accessions	Q3UHD1, Q3UH36, Q8CGM0	Gene names	Bai1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1 precursor.

BAI2_MOUSE
NC score	0.479749 (rank : 52)	θ value	1.9326e-10 (rank : 48)
Query Neighborhood Hits	227	Target Neighborhood Hits	323	Shared Neighborhood Hits	91
SwissProt Accessions	Q8CGM1, Q3TYC8, Q3UN11, Q3UNE2, Q6PGN0	Gene names	Bai2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 2 precursor.

BAI1_HUMAN
NC score	0.478930 (rank : 53)	θ value	4.76016e-09 (rank : 53)
Query Neighborhood Hits	227	Target Neighborhood Hits	375	Shared Neighborhood Hits	94
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

BAI3_HUMAN
NC score	0.476190 (rank : 54)	θ value	6.87365e-08 (rank : 59)
Query Neighborhood Hits	227	Target Neighborhood Hits	246	Shared Neighborhood Hits	88
SwissProt Accessions	O60242, O60297	Gene names	BAI3, KIAA0550
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

BAI3_MOUSE
NC score	0.475267 (rank : 55)	θ value	6.87365e-08 (rank : 60)
Query Neighborhood Hits	227	Target Neighborhood Hits	250	Shared Neighborhood Hits	87
SwissProt Accessions	Q80ZF8	Gene names	Bai3
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

UNC5C_MOUSE
NC score	0.465587 (rank : 56)	θ value	7.59969e-07 (rank : 63)
Query Neighborhood Hits	227	Target Neighborhood Hits	225	Shared Neighborhood Hits	76
SwissProt Accessions	O08747, Q8CD16	Gene names	Unc5c, Rcm, Unc5h3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3) (Rostral cerebellar malformation protein).

UNC5C_HUMAN
NC score	0.465134 (rank : 57)	θ value	7.59969e-07 (rank : 62)
Query Neighborhood Hits	227	Target Neighborhood Hits	226	Shared Neighborhood Hits	76
SwissProt Accessions	O95185, Q8IUT0	Gene names	UNC5C, UNC5H3
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5C precursor (Unc-5 homolog C) (Unc-5 homolog 3).

CO8A_HUMAN
NC score	0.456940 (rank : 58)	θ value	2.88788e-06 (rank : 67)
Query Neighborhood Hits	227	Target Neighborhood Hits	200	Shared Neighborhood Hits	78
SwissProt Accessions	P07357, Q13668, Q9H130	Gene names	C8A
Domain Architecture
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

UNC5D_HUMAN
NC score	0.456931 (rank : 59)	θ value	2.21117e-06 (rank : 66)
Query Neighborhood Hits	227	Target Neighborhood Hits	267	Shared Neighborhood Hits	78
SwissProt Accessions	Q6UXZ4, Q8WYP7	Gene names	UNC5D, KIAA1777, UNC5H4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

CO8A_MOUSE
NC score	0.456106 (rank : 60)	θ value	3.64472e-09 (rank : 51)
Query Neighborhood Hits	227	Target Neighborhood Hits	182	Shared Neighborhood Hits	75
SwissProt Accessions	Q8K182, Q8CHJ9, Q8CHK1	Gene names	C8a
Domain Architecture	No domain graphic available
Description	Complement component C8 alpha chain precursor (Complement component 8 subunit alpha).

UNC5D_MOUSE
NC score	0.453206 (rank : 61)	θ value	2.88788e-06 (rank : 68)
Query Neighborhood Hits	227	Target Neighborhood Hits	268	Shared Neighborhood Hits	79
SwissProt Accessions	Q8K1S2	Gene names	Unc5d, Unc5h4
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5D precursor (Unc-5 homolog D) (Unc-5 homolog 4).

SEM5A_HUMAN
NC score	0.451732 (rank : 62)	θ value	4.59992e-12 (rank : 41)
Query Neighborhood Hits	227	Target Neighborhood Hits	177	Shared Neighborhood Hits	89
SwissProt Accessions	Q13591, O60408, Q1RLL9	Gene names	SEMA5A, SEMAF
Domain Architecture
Description	Semaphorin-5A precursor (Semaphorin F) (Sema F).

CO6_HUMAN
NC score	0.444846 (rank : 63)	θ value	1.09739e-05 (rank : 72)
Query Neighborhood Hits	227	Target Neighborhood Hits	331	Shared Neighborhood Hits	93
SwissProt Accessions	P13671	Gene names	C6
Domain Architecture
Description	Complement component C6 precursor.

SEM5A_MOUSE
NC score	0.442253 (rank : 64)	θ value	1.33837e-11 (rank : 43)
Query Neighborhood Hits	227	Target Neighborhood Hits	162	Shared Neighborhood Hits	85
SwissProt Accessions	Q62217	Gene names	Sema5a, Semaf, SemF
Domain Architecture
Description	Semaphorin-5A precursor (Semaphorin F) (Sema F).

SEM5B_MOUSE
NC score	0.438923 (rank : 65)	θ value	1.133e-10 (rank : 46)
Query Neighborhood Hits	227	Target Neighborhood Hits	190	Shared Neighborhood Hits	87
SwissProt Accessions	Q60519	Gene names	Sema5b, Semag, SemG
Domain Architecture
Description	Semaphorin-5B precursor (Semaphorin G) (Sema G).

SEM5B_HUMAN
NC score	0.437035 (rank : 66)	θ value	8.67504e-11 (rank : 45)
Query Neighborhood Hits	227	Target Neighborhood Hits	178	Shared Neighborhood Hits	86
SwissProt Accessions	Q9P283, Q6UY12	Gene names	SEMA5B, KIAA1445
Domain Architecture
Description	Semaphorin-5B precursor.

SSPO_MOUSE
NC score	0.435162 (rank : 67)	θ value	1.133e-10 (rank : 47)
Query Neighborhood Hits	227	Target Neighborhood Hits	800	Shared Neighborhood Hits	157
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

CO8B_MOUSE
NC score	0.430253 (rank : 68)	θ value	0.00020696 (rank : 80)
Query Neighborhood Hits	227	Target Neighborhood Hits	224	Shared Neighborhood Hits	78
SwissProt Accessions	Q8BH35, Q4VAH1, Q8CHJ5, Q8CHJ6, Q8VC14	Gene names	C8b
Domain Architecture	No domain graphic available
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

CILP2_HUMAN
NC score	0.420862 (rank : 69)	θ value	9.92553e-07 (rank : 64)
Query Neighborhood Hits	227	Target Neighborhood Hits	307	Shared Neighborhood Hits	73
SwissProt Accessions	Q8IUL8, Q6NV88, Q8N4A6, Q8WV21	Gene names	CILP2
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 2 precursor (CILP-2) [Contains: Cartilage intermediate layer protein 2 C1; Cartilage intermediate layer protein 2 C2].

ADAM8_HUMAN
NC score	0.415881 (rank : 70)	θ value	0.00298849 (rank : 90)
Query Neighborhood Hits	227	Target Neighborhood Hits	327	Shared Neighborhood Hits	97
SwissProt Accessions	P78325	Gene names	ADAM8, MS2
Domain Architecture
Description	ADAM 8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 8) (Cell surface antigen MS2) (CD156a antigen) (CD156).

ADA19_MOUSE
NC score	0.414146 (rank : 71)	θ value	8.97725e-08 (rank : 61)
Query Neighborhood Hits	227	Target Neighborhood Hits	315	Shared Neighborhood Hits	91
SwissProt Accessions	O35674	Gene names	Adam19, Mltnb
Domain Architecture
Description	ADAM 19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 19) (Meltrin beta).

ADAM8_MOUSE
NC score	0.413914 (rank : 72)	θ value	0.47712 (rank : 121)
Query Neighborhood Hits	227	Target Neighborhood Hits	326	Shared Neighborhood Hits	101
SwissProt Accessions	Q05910	Gene names	Adam8, Ms2
Domain Architecture
Description	ADAM 8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 8) (Cell surface antigen MS2) (Macrophage cysteine-rich glycoprotein) (CD156 antigen).

CO7_HUMAN
NC score	0.410415 (rank : 73)	θ value	3.08544e-08 (rank : 58)
Query Neighborhood Hits	227	Target Neighborhood Hits	278	Shared Neighborhood Hits	88
SwissProt Accessions	P10643, Q6P3T5, Q92489	Gene names	C7
Domain Architecture
Description	Complement component C7 precursor.

UNC5A_HUMAN
NC score	0.407939 (rank : 74)	θ value	6.43352e-06 (rank : 71)
Query Neighborhood Hits	227	Target Neighborhood Hits	198	Shared Neighborhood Hits	73
SwissProt Accessions	Q6ZN44, Q8TF26, Q96GP4	Gene names	UNC5A, KIAA1976, UNC5H1
Domain Architecture	No domain graphic available
Description	Netrin receptor UNC5A precursor (Unc-5 homolog A) (Unc-5 homolog 1).

ADA28_MOUSE
NC score	0.406483 (rank : 75)	θ value	0.0148317 (rank : 93)
Query Neighborhood Hits	227	Target Neighborhood Hits	241	Shared Neighborhood Hits	83
SwissProt Accessions	Q9JLN6, Q8K5D2, Q8K5D3	Gene names	Adam28
Domain Architecture
Description	ADAM 28 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 28) (Thymic epithelial cell-ADAM) (TECADAM).

ADA19_HUMAN
NC score	0.404484 (rank : 76)	θ value	2.44474e-05 (rank : 74)
Query Neighborhood Hits	227	Target Neighborhood Hits	381	Shared Neighborhood Hits	87
SwissProt Accessions	Q9H013, Q9BZL5, Q9UHP2	Gene names	ADAM19, MLTNB
Domain Architecture
Description	ADAM 19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 19) (Meltrin beta) (Metalloprotease and disintegrin dentritic antigen marker) (MADDAM).

ADA33_HUMAN
NC score	0.395450 (rank : 77)	θ value	0.000121331 (rank : 77)
Query Neighborhood Hits	227	Target Neighborhood Hits	264	Shared Neighborhood Hits	88
SwissProt Accessions	Q9BZ11, Q5JT75, Q5JT76, Q8N0W6	Gene names	ADAM33
Domain Architecture
Description	ADAM 33 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 33).

ADA28_HUMAN
NC score	0.394699 (rank : 78)	θ value	0.0330416 (rank : 97)
Query Neighborhood Hits	227	Target Neighborhood Hits	244	Shared Neighborhood Hits	86
SwissProt Accessions	Q9UKQ2, Q9Y339, Q9Y3S0	Gene names	ADAM28, MDCL
Domain Architecture
Description	ADAM 28 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 28) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein-L) (MDC-L) (eMDC II) (ADAM23).

CO8B_HUMAN
NC score	0.392427 (rank : 79)	θ value	0.000270298 (rank : 82)
Query Neighborhood Hits	227	Target Neighborhood Hits	199	Shared Neighborhood Hits	70
SwissProt Accessions	P07358	Gene names	C8B
Domain Architecture
Description	Complement component C8 beta chain precursor (Complement component 8 subunit beta).

ADA12_HUMAN
NC score	0.390841 (rank : 80)	θ value	0.00134147 (rank : 85)
Query Neighborhood Hits	227	Target Neighborhood Hits	224	Shared Neighborhood Hits	83
SwissProt Accessions	O43184, O60470	Gene names	ADAM12, MLTN
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

ADA12_MOUSE
NC score	0.383979 (rank : 81)	θ value	0.00228821 (rank : 89)
Query Neighborhood Hits	227	Target Neighborhood Hits	474	Shared Neighborhood Hits	86
SwissProt Accessions	Q61824	Gene names	Adam12, Mltna
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

ADEC1_HUMAN
NC score	0.381443 (rank : 82)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	227	Target Neighborhood Hits	80	Shared Neighborhood Hits	62
SwissProt Accessions	O15204	Gene names	ADAMDEC1
Domain Architecture	No domain graphic available
Description	ADAM DEC1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain-like protein decysin 1) (ADAM-like protein decysin 1).

ADAM7_HUMAN
NC score	0.381441 (rank : 83)	θ value	1.29631e-06 (rank : 65)
Query Neighborhood Hits	227	Target Neighborhood Hits	221	Shared Neighborhood Hits	88
SwissProt Accessions	Q9H2U9, O75959	Gene names	ADAM7, GP83
Domain Architecture
Description	ADAM 7 precursor (A disintegrin and metalloproteinase domain 7) (Sperm maturation-related glycoprotein GP-83).

ADAM7_MOUSE
NC score	0.380818 (rank : 84)	θ value	2.13673e-09 (rank : 49)
Query Neighborhood Hits	227	Target Neighborhood Hits	200	Shared Neighborhood Hits	85
SwissProt Accessions	O35227	Gene names	Adam7
Domain Architecture
Description	ADAM 7 precursor (A disintegrin and metalloproteinase domain 7).

ADA15_HUMAN
NC score	0.376085 (rank : 85)	θ value	7.1131e-05 (rank : 75)
Query Neighborhood Hits	227	Target Neighborhood Hits	288	Shared Neighborhood Hits	97
SwissProt Accessions	Q13444, Q13493, Q96C78	Gene names	ADAM15, MDC15
Domain Architecture
Description	ADAM 15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 15) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein 15) (MDC-15) (Metalloprotease RGD disintegrin protein) (Metargidin).

ADAM9_MOUSE
NC score	0.373338 (rank : 86)	θ value	0.00020696 (rank : 79)
Query Neighborhood Hits	227	Target Neighborhood Hits	325	Shared Neighborhood Hits	92
SwissProt Accessions	Q61072, Q60618, Q61853, Q80U94	Gene names	Adam9, Kiaa0021, Mdc9, Mltng
Domain Architecture	No domain graphic available
Description	ADAM 9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 9) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) (Meltrin gamma).

ADA33_MOUSE
NC score	0.365145 (rank : 87)	θ value	0.00102713 (rank : 84)
Query Neighborhood Hits	227	Target Neighborhood Hits	231	Shared Neighborhood Hits	91
SwissProt Accessions	Q923W9	Gene names	Adam33
Domain Architecture
Description	ADAM 33 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 33).

ADAM9_HUMAN
NC score	0.362191 (rank : 88)	θ value	0.000270298 (rank : 81)
Query Neighborhood Hits	227	Target Neighborhood Hits	243	Shared Neighborhood Hits	85
SwissProt Accessions	Q13443, Q10718, Q8NFM6	Gene names	ADAM9, KIAA0021, MCMP, MDC9, MLTNG
Domain Architecture
Description	ADAM 9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 9) (Metalloprotease/disintegrin/cysteine-rich protein 9) (Myeloma cell metalloproteinase) (Meltrin gamma) (Cellular disintegrin-related protein).

ADA15_MOUSE
NC score	0.348439 (rank : 89)	θ value	2.44474e-05 (rank : 73)
Query Neighborhood Hits	227	Target Neighborhood Hits	324	Shared Neighborhood Hits	104
SwissProt Accessions	O88839, Q3U7C2, Q8C7Z0, Q91VS9, Q9QYL2	Gene names	Adam15, Mdc15
Domain Architecture
Description	ADAM 15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 15) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein 15) (MDC-15) (Metalloprotease RGD disintegrin protein) (Metargidin) (AD56).

ADM1B_MOUSE
NC score	0.336507 (rank : 90)	θ value	0.0563607 (rank : 100)
Query Neighborhood Hits	227	Target Neighborhood Hits	236	Shared Neighborhood Hits	82
SwissProt Accessions	Q8R534, Q9R156	Gene names	Adam1b
Domain Architecture
Description	ADAM 1b precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 1b) (Fertilin alpha 1b subunit).

ADA21_MOUSE
NC score	0.332902 (rank : 91)	θ value	0.0148317 (rank : 92)
Query Neighborhood Hits	227	Target Neighborhood Hits	172	Shared Neighborhood Hits	78
SwissProt Accessions	Q9JI76	Gene names	Adam21, Adam31
Domain Architecture
Description	ADAM 21 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 21) (ADAM 31).

ADEC1_MOUSE
NC score	0.330444 (rank : 92)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	227	Target Neighborhood Hits	85	Shared Neighborhood Hits	63
SwissProt Accessions	Q9R0X2	Gene names	Adamdec1
Domain Architecture	No domain graphic available
Description	ADAM DEC1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain-like protein decysin 1) (ADAM-like protein decysin 1).

ADA24_MOUSE
NC score	0.329180 (rank : 93)	θ value	0.00175202 (rank : 86)
Query Neighborhood Hits	227	Target Neighborhood Hits	230	Shared Neighborhood Hits	85
SwissProt Accessions	Q9R160	Gene names	Adam24
Domain Architecture
Description	ADAM 24 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 24) (Testase 1).

ADM1A_MOUSE
NC score	0.328587 (rank : 94)	θ value	0.0736092 (rank : 104)
Query Neighborhood Hits	227	Target Neighborhood Hits	230	Shared Neighborhood Hits	92
SwissProt Accessions	Q60813, Q60617, Q80WR7, Q8R533	Gene names	Adam1a, Adam1, Ftna
Domain Architecture
Description	ADAM 1a precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 1a) (Fertilin alpha 1a subunit).

ADA25_MOUSE
NC score	0.322369 (rank : 95)	θ value	0.000158464 (rank : 78)
Query Neighborhood Hits	227	Target Neighborhood Hits	213	Shared Neighborhood Hits	89
SwissProt Accessions	Q9R159, Q9D4E4	Gene names	Adam25
Domain Architecture
Description	ADAM 25 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 25) (Testase 2).

ADA29_HUMAN
NC score	0.321289 (rank : 96)	θ value	0.00175202 (rank : 87)
Query Neighborhood Hits	227	Target Neighborhood Hits	247	Shared Neighborhood Hits	74
SwissProt Accessions	Q9UKF5, Q9UHP1, Q9UKF3, Q9UKF4	Gene names	ADAM29
Domain Architecture
Description	ADAM 29 precursor (A disintegrin and metalloproteinase domain 29).

ADA22_HUMAN
NC score	0.320266 (rank : 97)	θ value	2.36792 (rank : 155)
Query Neighborhood Hits	227	Target Neighborhood Hits	211	Shared Neighborhood Hits	80
SwissProt Accessions	Q9P0K1, O75075, O75076, Q9P0K2, Q9UIA1, Q9UKK2	Gene names	ADAM22, MDC2
Domain Architecture
Description	ADAM 22 precursor (A disintegrin and metalloproteinase domain 22) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2) (Metalloproteinase-disintegrin ADAM22-3).

AD26A_MOUSE
NC score	0.314985 (rank : 98)	θ value	0.000786445 (rank : 83)
Query Neighborhood Hits	227	Target Neighborhood Hits	165	Shared Neighborhood Hits	80
SwissProt Accessions	Q9R158	Gene names	Adam26a, Adam26
Domain Architecture
Description	ADAM 26A precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 26A) (Testase-3).

ADA21_HUMAN
NC score	0.313673 (rank : 99)	θ value	1.81305 (rank : 143)
Query Neighborhood Hits	227	Target Neighborhood Hits	181	Shared Neighborhood Hits	81
SwissProt Accessions	Q9UKJ8, O43507	Gene names	ADAM21
Domain Architecture
Description	ADAM 21 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 21).

ADA22_MOUSE
NC score	0.311659 (rank : 100)	θ value	2.36792 (rank : 156)
Query Neighborhood Hits	227	Target Neighborhood Hits	225	Shared Neighborhood Hits	85
SwissProt Accessions	Q9R1V6, Q5TLI8, Q5TLI9, Q5TLJ0, Q5TLJ1, Q5TLJ2, Q5TLJ3, Q5TLJ4, Q5TLJ5, Q5TLJ6, Q5TLJ7, Q5TLJ8, Q5TLJ9, Q5TLK0, Q5TLK1, Q5TLK2, Q5TLK3, Q5TLK4, Q5TLK5, Q5TLK6, Q5TLK7, Q5TLK8, Q8BSF2, Q9R1V5	Gene names	Adam22
Domain Architecture
Description	ADAM 22 precursor (A disintegrin and metalloproteinase domain 22).

ADA23_MOUSE
NC score	0.309138 (rank : 101)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	227	Target Neighborhood Hits	245	Shared Neighborhood Hits	82
SwissProt Accessions	Q9R1V7, Q6QDY9, Q6QDZ0, Q8CC33	Gene names	Adam23, Mdc3
Domain Architecture	No domain graphic available
Description	ADAM 23 precursor (A disintegrin and metalloproteinase domain 23) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3) (MDC-3).

HMCN1_HUMAN
NC score	0.304764 (rank : 102)	θ value	1.38178e-16 (rank : 37)
Query Neighborhood Hits	227	Target Neighborhood Hits	983	Shared Neighborhood Hits	129
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

CILP1_MOUSE
NC score	0.304615 (rank : 103)	θ value	0.0113563 (rank : 91)
Query Neighborhood Hits	227	Target Neighborhood Hits	282	Shared Neighborhood Hits	75
SwissProt Accessions	Q66K08, Q7TSS0, Q7TSS1, Q8BV01	Gene names	Cilp
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

ADA23_HUMAN
NC score	0.301829 (rank : 104)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	227	Target Neighborhood Hits	235	Shared Neighborhood Hits	80
SwissProt Accessions	O75077	Gene names	ADAM23, MDC3
Domain Architecture	No domain graphic available
Description	ADAM 23 precursor (A disintegrin and metalloproteinase domain 23) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3) (MDC-3).

CILP1_HUMAN
NC score	0.297483 (rank : 105)	θ value	0.279714 (rank : 113)
Query Neighborhood Hits	227	Target Neighborhood Hits	266	Shared Neighborhood Hits	74
SwissProt Accessions	O75339, Q6UW99, Q8IYI5	Gene names	CILP
Domain Architecture	No domain graphic available
Description	Cartilage intermediate layer protein 1 precursor (CILP-1) (Cartilage intermediate-layer protein) [Contains: Cartilage intermediate layer protein 1 C1; Cartilage intermediate layer protein 1 C2].

ADA11_MOUSE
NC score	0.293167 (rank : 106)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	227	Target Neighborhood Hits	263	Shared Neighborhood Hits	81
SwissProt Accessions	Q9R1V4	Gene names	Adam11, Mdc
Domain Architecture
Description	ADAM 11 precursor (A disintegrin and metalloproteinase domain 11) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein) (MDC).

ADAM2_MOUSE
NC score	0.271150 (rank : 107)	θ value	1.06291 (rank : 136)
Query Neighborhood Hits	227	Target Neighborhood Hits	209	Shared Neighborhood Hits	80
SwissProt Accessions	Q60718, Q60814, Q9D4G3, Q9QWJ0	Gene names	Adam2, Ftnb
Domain Architecture
Description	ADAM 2 precursor (A disintegrin and metalloproteinase domain 2) (Fertilin subunit beta) (PH-30) (PH30) (PH30-beta).

ADA11_HUMAN
NC score	0.268672 (rank : 108)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	227	Target Neighborhood Hits	259	Shared Neighborhood Hits	81
SwissProt Accessions	O75078, Q14808, Q14809, Q14810	Gene names	ADAM11, MDC
Domain Architecture
Description	ADAM 11 precursor (A disintegrin and metalloproteinase domain 11) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein) (MDC).

ADA20_HUMAN
NC score	0.268482 (rank : 109)	θ value	2.36792 (rank : 154)
Query Neighborhood Hits	227	Target Neighborhood Hits	143	Shared Neighborhood Hits	78
SwissProt Accessions	O43506, Q9UKJ9	Gene names	ADAM20
Domain Architecture
Description	ADAM 20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 20).

ADA32_HUMAN
NC score	0.264430 (rank : 110)	θ value	0.0563607 (rank : 99)
Query Neighborhood Hits	227	Target Neighborhood Hits	216	Shared Neighborhood Hits	79
SwissProt Accessions	Q8TC27, Q8TC42	Gene names	ADAM32
Domain Architecture	No domain graphic available
Description	ADAM 32 precursor (A disintegrin and metalloproteinase domain 32).

ADA32_MOUSE
NC score	0.262778 (rank : 111)	θ value	0.0330416 (rank : 98)
Query Neighborhood Hits	227	Target Neighborhood Hits	219	Shared Neighborhood Hits	83
SwissProt Accessions	Q8K410, Q6P901, Q8BJ80	Gene names	Adam32
Domain Architecture	No domain graphic available
Description	ADAM 32 precursor (A disintegrin and metalloproteinase domain 32).

ADA17_MOUSE
NC score	0.258034 (rank : 112)	θ value	0.0736092 (rank : 103)
Query Neighborhood Hits	227	Target Neighborhood Hits	201	Shared Neighborhood Hits	80
SwissProt Accessions	Q9Z0F8, O88726, Q9R1U4, Q9Z0K3	Gene names	Adam17, Tace
Domain Architecture
Description	ADAM 17 precursor (EC 3.4.24.86) (A disintegrin and metalloproteinase domain 17) (TNF-alpha-converting enzyme) (TNF-alpha convertase) (CD156b antigen).

ADA10_MOUSE
NC score	0.251539 (rank : 113)	θ value	0.0330416 (rank : 96)
Query Neighborhood Hits	227	Target Neighborhood Hits	194	Shared Neighborhood Hits	79
SwissProt Accessions	O35598	Gene names	Adam10, Kuz, Madm
Domain Architecture
Description	ADAM 10 precursor (EC 3.4.24.81) (A disintegrin and metalloproteinase domain 10) (Mammalian disintegrin-metalloprotease) (Kuzbanian protein homolog).

ADA10_HUMAN
NC score	0.249793 (rank : 114)	θ value	0.0252991 (rank : 94)
Query Neighborhood Hits	227	Target Neighborhood Hits	189	Shared Neighborhood Hits	78
SwissProt Accessions	O14672, Q10742, Q92650	Gene names	ADAM10, KUZ, MADM
Domain Architecture
Description	ADAM 10 precursor (EC 3.4.24.81) (A disintegrin and metalloproteinase domain 10) (Mammalian disintegrin-metalloprotease) (Kuzbanian protein homolog) (CDw156c antigen).

ADA17_HUMAN
NC score	0.246414 (rank : 115)	θ value	0.0736092 (rank : 102)
Query Neighborhood Hits	227	Target Neighborhood Hits	223	Shared Neighborhood Hits	82
SwissProt Accessions	P78536, O60226	Gene names	ADAM17, CSVP, TACE
Domain Architecture
Description	ADAM 17 precursor (EC 3.4.24.86) (A disintegrin and metalloproteinase domain 17) (TNF-alpha-converting enzyme) (TNF-alpha convertase) (Snake venom-like protease) (CD156b antigen).

ADA18_MOUSE
NC score	0.245506 (rank : 116)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	227	Target Neighborhood Hits	227	Shared Neighborhood Hits	87
SwissProt Accessions	Q9R157, Q60621	Gene names	Adam18, Adam27, Dtgn3, Tmdc3
Domain Architecture
Description	ADAM 18 precursor (A disintegrin and metalloproteinase domain 18) (Transmembrane metalloproteinase-like, disintegrin-like, and cysteine- rich protein III) (tMDC III) (ADAM 27).

ADAM2_HUMAN
NC score	0.231261 (rank : 117)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	227	Target Neighborhood Hits	175	Shared Neighborhood Hits	74
SwissProt Accessions	Q99965, P78326, Q9UQQ8	Gene names	ADAM2, FTNB
Domain Architecture
Description	ADAM 2 precursor (A disintegrin and metalloproteinase domain 2) (Fertilin subunit beta) (PH-30) (PH30).

ADA18_HUMAN
NC score	0.220457 (rank : 118)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	227	Target Neighborhood Hits	184	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Y3Q7, Q6UXJ9	Gene names	ADAM18, TMDC3
Domain Architecture
Description	ADAM 18 precursor (A disintegrin and metalloproteinase domain 18) (Transmembrane metalloproteinase-like, disintegrin-like, and cysteine- rich protein III) (tMDC III).

ADA30_HUMAN
NC score	0.216772 (rank : 119)	θ value	0.365318 (rank : 118)
Query Neighborhood Hits	227	Target Neighborhood Hits	391	Shared Neighborhood Hits	80
SwissProt Accessions	Q9UKF2, Q9UKF1	Gene names	ADAM30
Domain Architecture
Description	ADAM 30 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 30).

WISP2_HUMAN
NC score	0.147978 (rank : 120)	θ value	1.81305 (rank : 153)
Query Neighborhood Hits	227	Target Neighborhood Hits	126	Shared Neighborhood Hits	59
SwissProt Accessions	O76076	Gene names	WISP2, CCN5, CT58, CTGFL
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L) (Connective tissue growth factor-related protein 58).

WISP2_MOUSE
NC score	0.145695 (rank : 121)	θ value	1.38821 (rank : 142)
Query Neighborhood Hits	227	Target Neighborhood Hits	129	Shared Neighborhood Hits	52
SwissProt Accessions	Q9Z0G4, Q8CIC8	Gene names	Wisp2, Ccn5, Ctgfl
Domain Architecture
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L).

WISP1_MOUSE
NC score	0.122912 (rank : 122)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	227	Target Neighborhood Hits	123	Shared Neighborhood Hits	53
SwissProt Accessions	O54775, Q80ZL1	Gene names	Wisp1, Ccn4, Elm1
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (ELM-1).

WISP1_HUMAN
NC score	0.116561 (rank : 123)	θ value	5.27518 (rank : 195)
Query Neighborhood Hits	227	Target Neighborhood Hits	121	Shared Neighborhood Hits	57
SwissProt Accessions	O95388, Q9HCS3	Gene names	WISP1, CCN4
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (Wnt-1- induced secreted protein).

NOV_MOUSE
NC score	0.104509 (rank : 124)	θ value	4.03905 (rank : 180)
Query Neighborhood Hits	227	Target Neighborhood Hits	130	Shared Neighborhood Hits	59
SwissProt Accessions	Q64299, Q8CA67	Gene names	Nov, Ccn3
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

CYR61_HUMAN
NC score	0.103041 (rank : 125)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	227	Target Neighborhood Hits	159	Shared Neighborhood Hits	66
SwissProt Accessions	O00622, O14934, O43775, Q9BZL7	Gene names	CYR61, CCN1, GIG1, IGFBP10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (Protein GIG1).

WISP3_HUMAN
NC score	0.097738 (rank : 126)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	227	Target Neighborhood Hits	87	Shared Neighborhood Hits	40
SwissProt Accessions	O95389, Q6UXH6	Gene names	WISP3, CCN6
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 3 precursor (WISP-3).

FRAS1_MOUSE
NC score	0.097712 (rank : 127)	θ value	0.125558 (rank : 107)
Query Neighborhood Hits	227	Target Neighborhood Hits	747	Shared Neighborhood Hits	108
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

KR106_HUMAN
NC score	0.097515 (rank : 128)	θ value	1.06291 (rank : 138)
Query Neighborhood Hits	227	Target Neighborhood Hits	347	Shared Neighborhood Hits	81
SwissProt Accessions	P60371	Gene names	KRTAP10-6, KAP10.6, KAP18-6, KRTAP10.6, KRTAP18-6, KRTAP18.6
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-6 (Keratin-associated protein 10.6) (High sulfur keratin-associated protein 10.6) (Keratin-associated protein 18-6) (Keratin-associated protein 18.6).

KR104_HUMAN
NC score	0.093424 (rank : 129)	θ value	0.0961366 (rank : 106)
Query Neighborhood Hits	227	Target Neighborhood Hits	313	Shared Neighborhood Hits	72
SwissProt Accessions	P60372	Gene names	KRTAP10-4, KAP10.4, KAP18-4, KRTAP10.4, KRTAP18-4, KRTAP18.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-4 (Keratin-associated protein 10.4) (High sulfur keratin-associated protein 10.4) (Keratin-associated protein 18-4) (Keratin-associated protein 18.4).

NOV_HUMAN
NC score	0.092015 (rank : 130)	θ value	5.27518 (rank : 191)
Query Neighborhood Hits	227	Target Neighborhood Hits	128	Shared Neighborhood Hits	55
SwissProt Accessions	P48745, Q96BY5	Gene names	NOV, CCN3, IGFBP9, NOVH
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

CYR61_MOUSE
NC score	0.088746 (rank : 131)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	227	Target Neighborhood Hits	156	Shared Neighborhood Hits	57
SwissProt Accessions	P18406	Gene names	Cyr61, Ccn1, Igfbp10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (3CH61).

KR102_HUMAN
NC score	0.086533 (rank : 132)	θ value	1.81305 (rank : 146)
Query Neighborhood Hits	227	Target Neighborhood Hits	264	Shared Neighborhood Hits	64
SwissProt Accessions	P60368, Q70LJ5	Gene names	KRTAP10-2, KAP10.2, KAP18-2, KRTAP10.2, KRTAP18-2, KRTAP18.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-2 (Keratin-associated protein 10.2) (High sulfur keratin-associated protein 10.2) (Keratin-associated protein 18-2) (Keratin-associated protein 18.2).

RSPO4_MOUSE
NC score	0.083490 (rank : 133)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	227	Target Neighborhood Hits	110	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BJ73	Gene names	Rspo4
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (Cysteine-rich and single thrombospondin domain-containing protein 4) (Cristin-4) (mCristin-4).

CO9_MOUSE
NC score	0.082273 (rank : 134)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	227	Target Neighborhood Hits	153	Shared Neighborhood Hits	28
SwissProt Accessions	P06683, Q91XA7	Gene names	C9
Domain Architecture
Description	Complement component C9 precursor.

CTGF_MOUSE
NC score	0.081978 (rank : 135)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	227	Target Neighborhood Hits	124	Shared Neighborhood Hits	53
SwissProt Accessions	P29268, Q922U0	Gene names	Ctgf, Ccn2, Fisp-12, Fisp12, Hcs24
Domain Architecture
Description	Connective tissue growth factor precursor (Protein FISP-12) (Hypertrophic chondrocyte-specific protein 24).

KR107_HUMAN
NC score	0.081579 (rank : 136)	θ value	0.125558 (rank : 108)
Query Neighborhood Hits	227	Target Neighborhood Hits	330	Shared Neighborhood Hits	70
SwissProt Accessions	P60409, Q70LJ2	Gene names	KRTAP10-7, KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-7 (Keratin-associated protein 10.7) (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7).

RSPO1_HUMAN
NC score	0.081052 (rank : 137)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	227	Target Neighborhood Hits	101	Shared Neighborhood Hits	46
SwissProt Accessions	Q2MKA7, Q5T0F2, Q8N7L5	Gene names	RSPO1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (hRspo1).

FRAS1_HUMAN
NC score	0.079525 (rank : 138)	θ value	4.03905 (rank : 173)
Query Neighborhood Hits	227	Target Neighborhood Hits	759	Shared Neighborhood Hits	103
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

MMP26_HUMAN
NC score	0.078745 (rank : 139)	θ value	0.0736092 (rank : 105)
Query Neighborhood Hits	227	Target Neighborhood Hits	56	Shared Neighborhood Hits	44
SwissProt Accessions	Q9NRE1, Q9GZS2, Q9NR87	Gene names	MMP26
Domain Architecture
Description	Matrix metalloproteinase-26 precursor (EC 3.4.24.-) (MMP-26) (Matrilysin-2) (Endometase).

CTGF_HUMAN
NC score	0.078062 (rank : 140)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	227	Target Neighborhood Hits	128	Shared Neighborhood Hits	53
SwissProt Accessions	P29279, Q96QX2	Gene names	CTGF, CCN2, HCS24
Domain Architecture
Description	Connective tissue growth factor precursor (Hypertrophic chondrocyte- specific protein 24).

SPON2_HUMAN
NC score	0.075342 (rank : 141)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	227	Target Neighborhood Hits	53	Shared Neighborhood Hits	33
SwissProt Accessions	Q9BUD6, Q9ULW1	Gene names	SPON2, DIL1
Domain Architecture	No domain graphic available
Description	Spondin-2 precursor (Mindin) (Differentially expressed in cancerous and non-cancerous lung cells 1) (DIL-1).

KRA98_HUMAN
NC score	0.074935 (rank : 142)	θ value	3.0926 (rank : 166)
Query Neighborhood Hits	227	Target Neighborhood Hits	185	Shared Neighborhood Hits	49
SwissProt Accessions	Q9BYQ0	Gene names	KRTAP9-8, KAP9.8, KRTAP9.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-8 (Keratin-associated protein 9.8) (Ultrahigh sulfur keratin-associated protein 9.8).

CO9_HUMAN
NC score	0.073344 (rank : 143)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	227	Target Neighborhood Hits	147	Shared Neighborhood Hits	23
SwissProt Accessions	P02748	Gene names	C9
Domain Architecture
Description	Complement component C9 precursor [Contains: Complement component C9a; Complement component C9b].

MMP7_MOUSE
NC score	0.068801 (rank : 144)	θ value	0.813845 (rank : 134)
Query Neighborhood Hits	227	Target Neighborhood Hits	60	Shared Neighborhood Hits	48
SwissProt Accessions	Q10738	Gene names	Mmp7
Domain Architecture
Description	Matrilysin precursor (EC 3.4.24.23) (Pump-1 protease) (Uterine metalloproteinase) (Matrix metalloproteinase-7) (MMP-7) (Matrin).

RSPO1_MOUSE
NC score	0.068144 (rank : 145)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	227	Target Neighborhood Hits	85	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Z132, Q3V1S3	Gene names	Rspo1
Domain Architecture	No domain graphic available
Description	R-spondin-1 precursor (Roof plate-specific spondin-1) (Cysteine-rich and single thrombospondin domain-containing protein 3) (Cristin-3) (mCristin-3).

ZAN_MOUSE
NC score	0.065924 (rank : 146)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	227	Target Neighborhood Hits	808	Shared Neighborhood Hits	108
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

TSP3_HUMAN
NC score	0.065060 (rank : 147)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	227	Target Neighborhood Hits	250	Shared Neighborhood Hits	30
SwissProt Accessions	P49746, Q8WV34	Gene names	THBS3, TSP3
Domain Architecture
Description	Thrombospondin-3 precursor.

KRA92_HUMAN
NC score	0.065043 (rank : 148)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	227	Target Neighborhood Hits	198	Shared Neighborhood Hits	44
SwissProt Accessions	Q9BYQ4	Gene names	KRTAP9-2, KAP9.2, KRTAP9.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-2 (Keratin-associated protein 9.2) (Ultrahigh sulfur keratin-associated protein 9.2).

KRA51_HUMAN
NC score	0.064562 (rank : 149)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	227	Target Neighborhood Hits	288	Shared Neighborhood Hits	73
SwissProt Accessions	Q6L8H4	Gene names	KRTAP5-1, KAP5.1, KRTAP5.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-1 (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1).

KR101_HUMAN
NC score	0.064456 (rank : 150)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	227	Target Neighborhood Hits	261	Shared Neighborhood Hits	65
SwissProt Accessions	P60331	Gene names	KRTAP10-1, KAP10.1, KAP18-1, KRTAP10.1, KRTAP18-1, KRTAP18.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-1 (Keratin-associated protein 10.1) (High sulfur keratin-associated protein 10.1) (Keratin-associated protein 18-1) (Keratin-associated protein 18.1).

COMP_MOUSE
NC score	0.064454 (rank : 151)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	227	Target Neighborhood Hits	290	Shared Neighborhood Hits	35
SwissProt Accessions	Q9R0G6	Gene names	Comp
Domain Architecture
Description	Cartilage oligomeric matrix protein precursor (COMP).

COMP_HUMAN
NC score	0.064424 (rank : 152)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	227	Target Neighborhood Hits	258	Shared Neighborhood Hits	33
SwissProt Accessions	P49747, O14592, Q16388, Q16389, Q8N4T2	Gene names	COMP
Domain Architecture
Description	Cartilage oligomeric matrix protein precursor (COMP).

TSP3_MOUSE
NC score	0.064024 (rank : 153)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	227	Target Neighborhood Hits	247	Shared Neighborhood Hits	26
SwissProt Accessions	Q05895, Q6LCE0	Gene names	Thbs3, Tsp3
Domain Architecture
Description	Thrombospondin-3 precursor.

KR109_HUMAN
NC score	0.063413 (rank : 154)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	227	Target Neighborhood Hits	226	Shared Neighborhood Hits	48
SwissProt Accessions	P60411, Q70LJ1	Gene names	KRTAP10-9, KAP10.9, KAP18-9, KRTAP10.9, KRTAP18-9, KRTAP18.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-9 (Keratin-associated protein 10.9) (High sulfur keratin-associated protein 10.9) (Keratin-associated protein 18-9) (Keratin-associated protein 18.9).

SPON2_MOUSE
NC score	0.062341 (rank : 155)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	227	Target Neighborhood Hits	42	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BMS2, Q6SJD8	Gene names	Spon2
Domain Architecture	No domain graphic available
Description	Spondin-2 precursor (Mindin).

KRA93_HUMAN
NC score	0.061646 (rank : 156)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	227	Target Neighborhood Hits	203	Shared Neighborhood Hits	52
SwissProt Accessions	Q9BYQ3	Gene names	KRTAP9-3, KAP9.3, KRTAP9.3
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-3 (Keratin-associated protein 9.3) (Ultrahigh sulfur keratin-associated protein 9.3).

TSP4_HUMAN
NC score	0.061548 (rank : 157)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	227	Target Neighborhood Hits	277	Shared Neighborhood Hits	31
SwissProt Accessions	P35443, Q86TG2	Gene names	THBS4, TSP4
Domain Architecture
Description	Thrombospondin-4 precursor.

RSPO4_HUMAN
NC score	0.061337 (rank : 158)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	227	Target Neighborhood Hits	110	Shared Neighborhood Hits	35
SwissProt Accessions	Q2I0M5, Q9UGB2	Gene names	RSPO4, C20orf182
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (hRspo4).

TSP4_MOUSE
NC score	0.060844 (rank : 159)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	227	Target Neighborhood Hits	276	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Z1T2, Q9QYS3, Q9WUE0	Gene names	Thbs4, Tsp4
Domain Architecture
Description	Thrombospondin-4 precursor.

MMP2_HUMAN
NC score	0.060567 (rank : 160)	θ value	0.365318 (rank : 119)
Query Neighborhood Hits	227	Target Neighborhood Hits	79	Shared Neighborhood Hits	41
SwissProt Accessions	P08253	Gene names	MMP2, CLG4A
Domain Architecture
Description	72 kDa type IV collagenase precursor (EC 3.4.24.24) (72 kDa gelatinase) (Matrix metalloproteinase-2) (MMP-2) (Gelatinase A) (TBE- 1).

KR105_HUMAN
NC score	0.059366 (rank : 161)	θ value	1.38821 (rank : 139)
Query Neighborhood Hits	227	Target Neighborhood Hits	271	Shared Neighborhood Hits	64
SwissProt Accessions	P60370, Q70LJ3	Gene names	KRTAP10-5, KAP10.5, KAP18-5, KRTAP10.5, KRTAP18-5, KRTAP18.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-5 (Keratin-associated protein 10.5) (High sulfur keratin-associated protein 10.5) (Keratin-associated protein 18-5) (Keratin-associated protein 18.5).

MMP2_MOUSE
NC score	0.058870 (rank : 162)	θ value	0.365318 (rank : 120)
Query Neighborhood Hits	227	Target Neighborhood Hits	77	Shared Neighborhood Hits	41
SwissProt Accessions	P33434	Gene names	Mmp2
Domain Architecture
Description	72 kDa type IV collagenase precursor (EC 3.4.24.24) (72 kDa gelatinase) (Matrix metalloproteinase-2) (MMP-2) (Gelatinase A).

RSPO3_HUMAN
NC score	0.057897 (rank : 163)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	227	Target Neighborhood Hits	128	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BXY4, Q5VTV4, Q96K87	Gene names	RSPO3, PWTSR, THSD2
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2) (Protein with TSP type-1 repeat) (hPWTSR).

CRIM1_HUMAN
NC score	0.057128 (rank : 164)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	227	Target Neighborhood Hits	362	Shared Neighborhood Hits	66
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

SPR2K_MOUSE
NC score	0.056621 (rank : 165)	θ value	0.125558 (rank : 110)
Query Neighborhood Hits	227	Target Neighborhood Hits	28	Shared Neighborhood Hits	5
SwissProt Accessions	O70562	Gene names	Sprr2k
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2K.

KR10C_HUMAN
NC score	0.054928 (rank : 166)	θ value	6.88961 (rank : 201)
Query Neighborhood Hits	227	Target Neighborhood Hits	219	Shared Neighborhood Hits	55
SwissProt Accessions	P60413	Gene names	KRTAP10-12, KAP10.12, KAP18-12, KRTAP10.12, KRTAP18-12, KRTAP18.12
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-12 (Keratin-associated protein 10.12) (High sulfur keratin-associated protein 10.12) (Keratin-associated protein 18-12) (Keratin-associated protein 18.12).

KR10B_HUMAN
NC score	0.054596 (rank : 167)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	227	Target Neighborhood Hits	269	Shared Neighborhood Hits	56
SwissProt Accessions	P60412	Gene names	KRTAP10-11, KAP10.11, KAP18-11, KRTAP10.11, KRTAP18-11, KRTAP18.11
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-11 (Keratin-associated protein 10.11) (High sulfur keratin-associated protein 10.11) (Keratin-associated protein 18-11) (Keratin-associated protein 18.11).

NFX1_HUMAN
NC score	0.053626 (rank : 168)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	227	Target Neighborhood Hits	405	Shared Neighborhood Hits	56
SwissProt Accessions	Q12986	Gene names	NFX1
Domain Architecture
Description	Transcriptional repressor NF-X1 (EC 6.3.2.-) (Nuclear transcription factor, X box-binding, 1).

MMP13_MOUSE
NC score	0.053028 (rank : 169)	θ value	0.0563607 (rank : 101)
Query Neighborhood Hits	227	Target Neighborhood Hits	56	Shared Neighborhood Hits	37
SwissProt Accessions	P33435	Gene names	Mmp13
Domain Architecture
Description	Collagenase 3 precursor (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13).

RSPO3_MOUSE
NC score	0.052734 (rank : 170)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	227	Target Neighborhood Hits	120	Shared Neighborhood Hits	36
SwissProt Accessions	Q2TJ95, Q3SYI9, Q5R2V4, Q8BVW2, Q9CSB2	Gene names	Rspo3
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (Cysteine-rich and single thrombospondin domain-containing protein 1) (Cristin-1) (Nucleopondin) (Cabriolet).

MMP9_MOUSE
NC score	0.052661 (rank : 171)	θ value	0.279714 (rank : 116)
Query Neighborhood Hits	227	Target Neighborhood Hits	151	Shared Neighborhood Hits	42
SwissProt Accessions	P41245, Q06788, Q9DC02	Gene names	Mmp9, Clg4b
Domain Architecture
Description	Matrix metalloproteinase-9 precursor (EC 3.4.24.35) (MMP-9) (92 kDa type IV collagenase) (92 kDa gelatinase) (Gelatinase B) (GELB).

KRA53_HUMAN
NC score	0.052513 (rank : 172)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	227	Target Neighborhood Hits	331	Shared Neighborhood Hits	71
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

TENX_HUMAN
NC score	0.052363 (rank : 173)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	227	Target Neighborhood Hits	789	Shared Neighborhood Hits	99
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

RSPO2_HUMAN
NC score	0.051284 (rank : 174)	θ value	5.27518 (rank : 193)
Query Neighborhood Hits	227	Target Neighborhood Hits	90	Shared Neighborhood Hits	32
SwissProt Accessions	Q6UXX9, Q4G0U4, Q8N6X6	Gene names	RSPO2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (hRspo2).

SREC_HUMAN
NC score	0.049563 (rank : 175)	θ value	2.36792 (rank : 161)
Query Neighborhood Hits	227	Target Neighborhood Hits	645	Shared Neighborhood Hits	92
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

NOTC3_HUMAN
NC score	0.049484 (rank : 176)	θ value	1.38821 (rank : 140)
Query Neighborhood Hits	227	Target Neighborhood Hits	1062	Shared Neighborhood Hits	107
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

MMP13_HUMAN
NC score	0.049368 (rank : 177)	θ value	0.163984 (rank : 112)
Query Neighborhood Hits	227	Target Neighborhood Hits	60	Shared Neighborhood Hits	36
SwissProt Accessions	P45452	Gene names	MMP13
Domain Architecture
Description	Collagenase 3 precursor (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13).

MMP9_HUMAN
NC score	0.049036 (rank : 178)	θ value	0.279714 (rank : 115)
Query Neighborhood Hits	227	Target Neighborhood Hits	125	Shared Neighborhood Hits	40
SwissProt Accessions	P14780, Q3LR70, Q8N725, Q9H4Z1	Gene names	MMP9, CLG4B
Domain Architecture
Description	Matrix metalloproteinase-9 precursor (EC 3.4.24.35) (MMP-9) (92 kDa type IV collagenase) (92 kDa gelatinase) (Gelatinase B) (GELB) [Contains: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9].

KRA15_HUMAN
NC score	0.048037 (rank : 179)	θ value	2.36792 (rank : 158)
Query Neighborhood Hits	227	Target Neighborhood Hits	126	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BYS1, Q52LP6	Gene names	KRTAP1-5, KAP1.5, KRTAP1.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 1-5 (Keratin-associated protein 1.5) (High sulfur keratin-associated protein 1.5).

KR108_HUMAN
NC score	0.047535 (rank : 180)	θ value	1.81305 (rank : 147)
Query Neighborhood Hits	227	Target Neighborhood Hits	226	Shared Neighborhood Hits	53
SwissProt Accessions	P60410	Gene names	KRTAP10-8, KAP10.8, KAP18-8, KRTAP10.8, KRTAP18-8, KRTAP18.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-8 (Keratin-associated protein 10.8) (High sulfur keratin-associated protein 10.8) (Keratin-associated protein 18-8) (Keratin-associated protein 18.8).

MMP28_HUMAN
NC score	0.047200 (rank : 181)	θ value	0.62314 (rank : 128)
Query Neighborhood Hits	227	Target Neighborhood Hits	55	Shared Neighborhood Hits	36
SwissProt Accessions	Q9H239, Q96TE2	Gene names	MMP28, MMP25
Domain Architecture
Description	Matrix metalloproteinase-28 precursor (EC 3.4.24.-) (MMP-28) (Epilysin).

LTBP2_HUMAN
NC score	0.047012 (rank : 182)	θ value	0.163984 (rank : 111)
Query Neighborhood Hits	227	Target Neighborhood Hits	552	Shared Neighborhood Hits	80
SwissProt Accessions	Q14767, Q99907, Q9NS51	Gene names	LTBP2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

FBN2_MOUSE
NC score	0.046816 (rank : 183)	θ value	0.279714 (rank : 114)
Query Neighborhood Hits	227	Target Neighborhood Hits	549	Shared Neighborhood Hits	93
SwissProt Accessions	Q61555, Q63957	Gene names	Fbn2, Fbn-2
Domain Architecture
Description	Fibrillin-2 precursor.

FBN2_HUMAN
NC score	0.046011 (rank : 184)	θ value	8.99809 (rank : 218)
Query Neighborhood Hits	227	Target Neighborhood Hits	560	Shared Neighborhood Hits	93
SwissProt Accessions	P35556	Gene names	FBN2
Domain Architecture
Description	Fibrillin-2 precursor.

NOTC2_MOUSE
NC score	0.045013 (rank : 185)	θ value	0.279714 (rank : 117)
Query Neighborhood Hits	227	Target Neighborhood Hits	1069	Shared Neighborhood Hits	97
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

MMP24_MOUSE
NC score	0.044609 (rank : 186)	θ value	4.03905 (rank : 178)
Query Neighborhood Hits	227	Target Neighborhood Hits	71	Shared Neighborhood Hits	42
SwissProt Accessions	Q9R0S2, Q9Z0J9	Gene names	Mmp24, Mmp21, Mt5mmp
Domain Architecture
Description	Matrix metalloproteinase-24 precursor (EC 3.4.24.-) (MMP-24) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP) (MMP-21).

MMP12_HUMAN
NC score	0.044513 (rank : 187)	θ value	1.81305 (rank : 151)
Query Neighborhood Hits	227	Target Neighborhood Hits	57	Shared Neighborhood Hits	37
SwissProt Accessions	P39900	Gene names	MMP12, HME
Domain Architecture
Description	Macrophage metalloelastase precursor (EC 3.4.24.65) (HME) (Matrix metalloproteinase-12) (MMP-12) (Macrophage elastase) (ME).

RSPO2_MOUSE
NC score	0.044190 (rank : 188)	θ value	6.88961 (rank : 209)
Query Neighborhood Hits	227	Target Neighborhood Hits	88	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BFU0, Q7TPX3	Gene names	Rspo2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (Cysteine-rich and single thrombospondin domain-containing protein 2) (Cristin-2) (mCristin-2).

NOTC2_HUMAN
NC score	0.044177 (rank : 189)	θ value	0.125558 (rank : 109)
Query Neighborhood Hits	227	Target Neighborhood Hits	1113	Shared Neighborhood Hits	104
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

MMP15_MOUSE
NC score	0.043980 (rank : 190)	θ value	2.36792 (rank : 159)
Query Neighborhood Hits	227	Target Neighborhood Hits	102	Shared Neighborhood Hits	36
SwissProt Accessions	O54732	Gene names	Mmp15
Domain Architecture
Description	Matrix metalloproteinase-15 precursor (EC 3.4.24.-) (MMP-15) (Membrane-type matrix metalloproteinase 2) (MT-MMP 2) (MTMMP2) (Membrane-type-2 matrix metalloproteinase) (MT2-MMP) (MT2MMP).

MMP14_MOUSE
NC score	0.043741 (rank : 191)	θ value	5.27518 (rank : 189)
Query Neighborhood Hits	227	Target Neighborhood Hits	57	Shared Neighborhood Hits	35
SwissProt Accessions	P53690, O08645, O35369	Gene names	Mmp14, Mtmmp
Domain Architecture
Description	Matrix metalloproteinase-14 precursor (EC 3.4.24.80) (MMP-14) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP) (MMP-X1) (MT-MMP).

VWF_HUMAN
NC score	0.043739 (rank : 192)	θ value	6.88961 (rank : 212)
Query Neighborhood Hits	227	Target Neighborhood Hits	396	Shared Neighborhood Hits	65
SwissProt Accessions	P04275	Gene names	VWF, F8VWF
Domain Architecture
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

MMP17_MOUSE
NC score	0.043656 (rank : 193)	θ value	0.62314 (rank : 127)
Query Neighborhood Hits	227	Target Neighborhood Hits	60	Shared Neighborhood Hits	32
SwissProt Accessions	Q9R0S3	Gene names	Mmp17, Mt4mmp
Domain Architecture
Description	Matrix metalloproteinase-17 precursor (EC 3.4.24.-) (MMP-17) (Membrane-type matrix metalloproteinase 4) (MT-MMP 4) (Membrane-type-4 matrix metalloproteinase) (MT4-MMP).

MMP14_HUMAN
NC score	0.043497 (rank : 194)	θ value	5.27518 (rank : 188)
Query Neighborhood Hits	227	Target Neighborhood Hits	60	Shared Neighborhood Hits	37
SwissProt Accessions	P50281, Q92678	Gene names	MMP14
Domain Architecture
Description	Matrix metalloproteinase-14 precursor (EC 3.4.24.80) (MMP-14) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP) (MMP- X1).

LTBP4_MOUSE
NC score	0.042966 (rank : 195)	θ value	0.62314 (rank : 126)
Query Neighborhood Hits	227	Target Neighborhood Hits	607	Shared Neighborhood Hits	76
SwissProt Accessions	Q8K4G1, Q8K4G0	Gene names	Ltbp4
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 4 precursor (LTBP-4).

MMP25_HUMAN
NC score	0.042919 (rank : 196)	θ value	0.813845 (rank : 133)
Query Neighborhood Hits	227	Target Neighborhood Hits	56	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NPA2, Q9H3Q0	Gene names	MMP25, MT6MMP
Domain Architecture
Description	Matrix metalloproteinase-25 precursor (EC 3.4.24.-) (MMP-25) (Membrane-type matrix metalloproteinase 6) (MT-MMP 6) (Membrane-type-6 matrix metalloproteinase) (MT6-MMP) (Leukolysin).

MMP21_MOUSE
NC score	0.042891 (rank : 197)	θ value	6.88961 (rank : 206)
Query Neighborhood Hits	227	Target Neighborhood Hits	59	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K3F2	Gene names	Mmp21
Domain Architecture	No domain graphic available
Description	Matrix metalloproteinase-21 precursor (EC 3.4.24.-) (MMP-21).

DLL1_MOUSE
NC score	0.042768 (rank : 198)	θ value	3.0926 (rank : 165)
Query Neighborhood Hits	227	Target Neighborhood Hits	456	Shared Neighborhood Hits	82
SwissProt Accessions	Q61483	Gene names	Dll1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1).

MMP24_HUMAN
NC score	0.042614 (rank : 199)	θ value	4.03905 (rank : 177)
Query Neighborhood Hits	227	Target Neighborhood Hits	66	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y5R2, Q9H440	Gene names	MMP24, MT5MMP
Domain Architecture
Description	Matrix metalloproteinase-24 precursor (EC 3.4.24.-) (MMP-24) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP).

KRA94_HUMAN
NC score	0.042519 (rank : 200)	θ value	8.99809 (rank : 220)
Query Neighborhood Hits	227	Target Neighborhood Hits	204	Shared Neighborhood Hits	46
SwissProt Accessions	Q9BYQ2	Gene names	KRTAP9-4, KAP9.4, KRTAP9.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-4 (Keratin-associated protein 9.4) (Ultrahigh sulfur keratin-associated protein 9.4).

LTBP2_MOUSE
NC score	0.042084 (rank : 201)	θ value	1.81305 (rank : 150)
Query Neighborhood Hits	227	Target Neighborhood Hits	617	Shared Neighborhood Hits	72
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

MMP8_MOUSE
NC score	0.041926 (rank : 202)	θ value	2.36792 (rank : 160)
Query Neighborhood Hits	227	Target Neighborhood Hits	57	Shared Neighborhood Hits	35
SwissProt Accessions	O70138, O88733	Gene names	Mmp8
Domain Architecture
Description	Neutrophil collagenase precursor (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (Collagenase 2).

MMP20_MOUSE
NC score	0.041782 (rank : 203)	θ value	6.88961 (rank : 205)
Query Neighborhood Hits	227	Target Neighborhood Hits	56	Shared Neighborhood Hits	34
SwissProt Accessions	P57748	Gene names	Mmp20
Domain Architecture
Description	Matrix metalloproteinase-20 precursor (EC 3.4.24.-) (MMP-20) (Enamel metalloproteinase) (Enamelysin).

MMP21_HUMAN
NC score	0.041411 (rank : 204)	θ value	3.0926 (rank : 168)
Query Neighborhood Hits	227	Target Neighborhood Hits	76	Shared Neighborhood Hits	33
SwissProt Accessions	Q8N119, Q8NG02	Gene names	MMP21
Domain Architecture	No domain graphic available
Description	Matrix metalloproteinase-21 precursor (EC 3.4.24.-) (MMP-21).

MMP16_HUMAN
NC score	0.041381 (rank : 205)	θ value	6.88961 (rank : 202)
Query Neighborhood Hits	227	Target Neighborhood Hits	68	Shared Neighborhood Hits	37
SwissProt Accessions	P51512, Q14824, Q52H48	Gene names	MMP16, MMPX2
Domain Architecture
Description	Matrix metalloproteinase-16 precursor (EC 3.4.24.-) (MMP-16) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP) (MMP- X2).

MMP16_MOUSE
NC score	0.041355 (rank : 206)	θ value	6.88961 (rank : 203)
Query Neighborhood Hits	227	Target Neighborhood Hits	72	Shared Neighborhood Hits	37
SwissProt Accessions	Q9WTR0, Q9ERT6	Gene names	Mmp16
Domain Architecture
Description	Matrix metalloproteinase-16 precursor (EC 3.4.24.-) (MMP-16) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP).

MMP20_HUMAN
NC score	0.040965 (rank : 207)	θ value	8.99809 (rank : 224)
Query Neighborhood Hits	227	Target Neighborhood Hits	56	Shared Neighborhood Hits	34
SwissProt Accessions	O60882, Q6DKT9	Gene names	MMP20
Domain Architecture
Description	Matrix metalloproteinase-20 precursor (EC 3.4.24.-) (MMP-20) (Enamel metalloproteinase) (Enamelysin).

DLL1_HUMAN
NC score	0.040436 (rank : 208)	θ value	6.88961 (rank : 198)
Query Neighborhood Hits	227	Target Neighborhood Hits	455	Shared Neighborhood Hits	85
SwissProt Accessions	O00548, Q9NU41, Q9UJV2	Gene names	DLL1
Domain Architecture
Description	Delta-like protein 1 precursor (Drosophila Delta homolog 1) (Delta1) (H-Delta-1).

MMP15_HUMAN
NC score	0.039801 (rank : 209)	θ value	4.03905 (rank : 176)
Query Neighborhood Hits	227	Target Neighborhood Hits	95	Shared Neighborhood Hits	34
SwissProt Accessions	P51511, Q14111	Gene names	MMP15
Domain Architecture
Description	Matrix metalloproteinase-15 precursor (EC 3.4.24.-) (MMP-15) (Membrane-type matrix metalloproteinase 2) (MT-MMP 2) (MTMMP2) (Membrane-type-2 matrix metalloproteinase) (MT2-MMP) (MT2MMP) (SMCP- 2).

MMP8_HUMAN
NC score	0.039420 (rank : 210)	θ value	4.03905 (rank : 179)
Query Neighborhood Hits	227	Target Neighborhood Hits	54	Shared Neighborhood Hits	33
SwissProt Accessions	P22894, Q45F99	Gene names	MMP8, CLG1
Domain Architecture
Description	Neutrophil collagenase precursor (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (PMNL collagenase) (PMNL-CL).

MMP3_MOUSE
NC score	0.038780 (rank : 211)	θ value	5.27518 (rank : 190)
Query Neighborhood Hits	227	Target Neighborhood Hits	53	Shared Neighborhood Hits	32
SwissProt Accessions	P28862	Gene names	Mmp3
Domain Architecture
Description	Stromelysin-1 precursor (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1) (SL-1) (EMS-2).

MMP3_HUMAN
NC score	0.038761 (rank : 212)	θ value	6.88961 (rank : 207)
Query Neighborhood Hits	227	Target Neighborhood Hits	50	Shared Neighborhood Hits	31
SwissProt Accessions	P08254, Q3B7S0	Gene names	MMP3, STMY1
Domain Architecture
Description	Stromelysin-1 precursor (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1) (SL-1).

MMP17_HUMAN
NC score	0.038186 (rank : 213)	θ value	6.88961 (rank : 204)
Query Neighborhood Hits	227	Target Neighborhood Hits	56	Shared Neighborhood Hits	33
SwissProt Accessions	Q9ULZ9, Q14850	Gene names	MMP17, MT4MMP
Domain Architecture
Description	Matrix metalloproteinase-17 precursor (EC 3.4.24.-) (MMP-17) (Membrane-type matrix metalloproteinase 4) (MT-MMP 4) (Membrane-type-4 matrix metalloproteinase) (MT4-MMP).

DNER_MOUSE
NC score	0.036715 (rank : 214)	θ value	4.03905 (rank : 172)
Query Neighborhood Hits	227	Target Neighborhood Hits	413	Shared Neighborhood Hits	71
SwissProt Accessions	Q8JZM4, Q3U697, Q8R226, Q8R4T6, Q8VD97	Gene names	Dner, Bet, Bret
Domain Architecture	No domain graphic available
Description	Delta and Notch-like epidermal growth factor-related receptor precursor (Brain EGF repeat-containing transmembrane protein).

CUBN_MOUSE
NC score	0.035327 (rank : 215)	θ value	3.0926 (rank : 163)
Query Neighborhood Hits	227	Target Neighborhood Hits	477	Shared Neighborhood Hits	59
SwissProt Accessions	Q9JLB4	Gene names	Cubn, Ifcr
Domain Architecture	No domain graphic available
Description	Cubilin precursor (Intrinsic factor-cobalamin receptor).

SPR2D_MOUSE
NC score	0.034024 (rank : 216)	θ value	1.81305 (rank : 152)
Query Neighborhood Hits	227	Target Neighborhood Hits	61	Shared Neighborhood Hits	10
SwissProt Accessions	O70555	Gene names	Sprr2d
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2D.

SPR2B_MOUSE
NC score	0.033188 (rank : 217)	θ value	3.0926 (rank : 170)
Query Neighborhood Hits	227	Target Neighborhood Hits	51	Shared Neighborhood Hits	11
SwissProt Accessions	O70554, Q7TSB2	Gene names	Sprr2b
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2B.

CELR2_HUMAN
NC score	0.028279 (rank : 218)	θ value	8.99809 (rank : 215)
Query Neighborhood Hits	227	Target Neighborhood Hits	657	Shared Neighborhood Hits	62
SwissProt Accessions	Q9HCU4, Q92566	Gene names	CELSR2, CDHF10, EGFL2, KIAA0279, MEGF3
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 2 precursor (Epidermal growth factor-like 2) (Multiple epidermal growth factor-like domains 3) (Flamingo 1).

LYAM2_HUMAN
NC score	0.027019 (rank : 219)	θ value	8.99809 (rank : 222)
Query Neighborhood Hits	227	Target Neighborhood Hits	394	Shared Neighborhood Hits	41
SwissProt Accessions	P16581, P16111	Gene names	SELE, ELAM1
Domain Architecture
Description	E-selectin precursor (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD62E antigen).

CELR2_MOUSE
NC score	0.025967 (rank : 220)	θ value	0.47712 (rank : 122)
Query Neighborhood Hits	227	Target Neighborhood Hits	584	Shared Neighborhood Hits	49
SwissProt Accessions	Q9R0M0, Q99K26, Q9Z2R4	Gene names	Celsr2
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 2 precursor (Flamingo 1) (mFmi1).

FA53B_HUMAN
NC score	0.025730 (rank : 221)	θ value	0.813845 (rank : 131)
Query Neighborhood Hits	227	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q14153, Q8N5S6	Gene names	FAM53B, KIAA0140
Domain Architecture	No domain graphic available
Description	Protein FAM53B.

LAMA5_MOUSE
NC score	0.025502 (rank : 222)	θ value	1.81305 (rank : 148)
Query Neighborhood Hits	227	Target Neighborhood Hits	828	Shared Neighborhood Hits	65
SwissProt Accessions	Q61001, Q9JHQ6	Gene names	Lama5
Domain Architecture
Description	Laminin alpha-5 chain precursor.

FA53B_MOUSE
NC score	0.024887 (rank : 223)	θ value	0.813845 (rank : 132)
Query Neighborhood Hits	227	Target Neighborhood Hits	29	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BGR5, Q3UGW1, Q8BI13	Gene names	Fam53b
Domain Architecture	No domain graphic available
Description	Protein FAM53B.

SPR2F_HUMAN
NC score	0.024510 (rank : 224)	θ value	6.88961 (rank : 211)
Query Neighborhood Hits	227	Target Neighborhood Hits	33	Shared Neighborhood Hits	5
SwissProt Accessions	Q96RM1	Gene names	SPRR2F
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2F (SPR-2F).

LAMB2_HUMAN
NC score	0.021578 (rank : 225)	θ value	3.0926 (rank : 167)
Query Neighborhood Hits	227	Target Neighborhood Hits	692	Shared Neighborhood Hits	51
SwissProt Accessions	P55268, Q16321	Gene names	LAMB2, LAMS
Domain Architecture
Description	Laminin beta-2 chain precursor (S-laminin) (Laminin B1s chain).

EGFL7_HUMAN
NC score	0.020722 (rank : 226)	θ value	5.27518 (rank : 186)
Query Neighborhood Hits	227	Target Neighborhood Hits	325	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UHF1, Q5M7Y5, Q5VUD5, Q96EG0	Gene names	EGFL7, MEGF7
Domain Architecture	No domain graphic available
Description	EGF-like domain-containing protein 7 precursor (Multiple EGF-like domain protein 7) (Multiple epidermal growth factor-like domain protein 7) (Vascular endothelial statin) (VE-statin) (NOTCH4-like protein) (ZNEU1).

NFAC1_HUMAN
NC score	0.019860 (rank : 227)	θ value	0.0252991 (rank : 95)
Query Neighborhood Hits	227	Target Neighborhood Hits	312	Shared Neighborhood Hits	12
SwissProt Accessions	O95644, Q12865, Q15793	Gene names	NFATC1, NFAT2, NFATC
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 1 (NFAT transcription complex cytosolic component) (NF-ATc1) (NF-ATc).

LAMB2_MOUSE
NC score	0.019225 (rank : 228)	θ value	1.81305 (rank : 149)
Query Neighborhood Hits	227	Target Neighborhood Hits	722	Shared Neighborhood Hits	57
SwissProt Accessions	Q61292, Q62182	Gene names	Lamb2, Lams
Domain Architecture
Description	Laminin beta-2 chain precursor (S-laminin) (S-LAM).

SPRR3_MOUSE
NC score	0.017307 (rank : 229)	θ value	1.38821 (rank : 141)
Query Neighborhood Hits	227	Target Neighborhood Hits	106	Shared Neighborhood Hits	8
SwissProt Accessions	O09116	Gene names	Sprr3
Domain Architecture
Description	Small proline-rich protein 3 (Cornifin beta).

EDIL3_HUMAN
NC score	0.015469 (rank : 230)	θ value	8.99809 (rank : 217)
Query Neighborhood Hits	227	Target Neighborhood Hits	292	Shared Neighborhood Hits	36
SwissProt Accessions	O43854, O43855	Gene names	EDIL3, DEL1
Domain Architecture
Description	EGF-like repeat and discoidin I-like domain-containing protein 3 precursor (EGF-like repeats and discoidin I-like domains protein 3) (Developmentally-regulated endothelial cell locus 1 protein) (Integrin-binding protein DEL1).

EDIL3_MOUSE
NC score	0.015146 (rank : 231)	θ value	6.88961 (rank : 199)
Query Neighborhood Hits	227	Target Neighborhood Hits	317	Shared Neighborhood Hits	39
SwissProt Accessions	O35474, O35475	Gene names	Edil3, Del1
Domain Architecture
Description	EGF-like repeat and discoidin I-like domain-containing protein 3 precursor (EGF-like repeats and discoidin I-like domains protein 3) (Developmentally-regulated endothelial cell locus 1 protein) (Integrin-binding protein DEL1).

EZH2_MOUSE
NC score	0.014859 (rank : 232)	θ value	1.81305 (rank : 145)
Query Neighborhood Hits	227	Target Neighborhood Hits	86	Shared Neighborhood Hits	13
SwissProt Accessions	Q61188, Q9R090	Gene names	Ezh2, Enx1h
Domain Architecture
Description	Enhancer of zeste homolog 2 (ENX-1).

EZH2_HUMAN
NC score	0.013518 (rank : 233)	θ value	1.81305 (rank : 144)
Query Neighborhood Hits	227	Target Neighborhood Hits	84	Shared Neighborhood Hits	11
SwissProt Accessions	Q15910, Q15755, Q92857	Gene names	EZH2
Domain Architecture
Description	Enhancer of zeste homolog 2 (ENX-1).

SPR1A_MOUSE
NC score	0.013043 (rank : 234)	θ value	4.03905 (rank : 182)
Query Neighborhood Hits	227	Target Neighborhood Hits	343	Shared Neighborhood Hits	22
SwissProt Accessions	Q62266	Gene names	Sprr1a
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein 1A) (SPR1A) (SPR1 A).

ZAR1_HUMAN
NC score	0.012380 (rank : 235)	θ value	5.27518 (rank : 196)
Query Neighborhood Hits	227	Target Neighborhood Hits	163	Shared Neighborhood Hits	5
SwissProt Accessions	Q86SH2	Gene names	ZAR1
Domain Architecture	No domain graphic available
Description	Zygote arrest 1 (Oocyte-specific maternal effect factor).

TM119_HUMAN
NC score	0.012113 (rank : 236)	θ value	4.03905 (rank : 183)
Query Neighborhood Hits	227	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	Q4V9L6, Q6UXE5, Q8N2F5	Gene names	TMEM119
Domain Architecture	No domain graphic available
Description	Transmembrane protein 119 precursor.

PERT_MOUSE
NC score	0.011845 (rank : 237)	θ value	8.99809 (rank : 225)
Query Neighborhood Hits	227	Target Neighborhood Hits	221	Shared Neighborhood Hits	24
SwissProt Accessions	P35419, Q8C8B1	Gene names	Tpo
Domain Architecture
Description	Thyroid peroxidase precursor (EC 1.11.1.8) (TPO).

RUNX3_MOUSE
NC score	0.011197 (rank : 238)	θ value	0.62314 (rank : 129)
Query Neighborhood Hits	227	Target Neighborhood Hits	113	Shared Neighborhood Hits	3
SwissProt Accessions	Q64131, Q99P92, Q9R199	Gene names	Runx3, Aml2, Cbfa3, Pebp2a3
Domain Architecture
Description	Runt-related transcription factor 3 (Core-binding factor, alpha 3 subunit) (CBF-alpha 3) (Acute myeloid leukemia 2 protein) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEBP2-alpha C) (PEA2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit).

LAG3_HUMAN
NC score	0.010902 (rank : 239)	θ value	8.99809 (rank : 221)
Query Neighborhood Hits	227	Target Neighborhood Hits	129	Shared Neighborhood Hits	4
SwissProt Accessions	P18627	Gene names	LAG3, FDC
Domain Architecture
Description	Lymphocyte activation gene 3 protein precursor (LAG-3) (FDC protein) (CD223 antigen).

CSMD2_HUMAN
NC score	0.010527 (rank : 240)	θ value	0.813845 (rank : 130)
Query Neighborhood Hits	227	Target Neighborhood Hits	188	Shared Neighborhood Hits	13
SwissProt Accessions	Q7Z408, Q5VT59, Q8N963, Q96Q03, Q9H4V7, Q9H4V8, Q9H4V9, Q9H4W0, Q9H4W1, Q9H4W2, Q9H4W3, Q9H4W4, Q9HCY5, Q9HCY6, Q9HCY7	Gene names	CSMD2, KIAA1884
Domain Architecture
Description	CUB and sushi domain-containing protein 2 (CUB and sushi multiple domains protein 2).

CSMD1_HUMAN
NC score	0.008048 (rank : 241)	θ value	5.27518 (rank : 184)
Query Neighborhood Hits	227	Target Neighborhood Hits	176	Shared Neighborhood Hits	11
SwissProt Accessions	Q96PZ7, Q96QU9, Q96RM4	Gene names	CSMD1, KIAA1890
Domain Architecture
Description	CUB and sushi domain-containing protein 1 precursor (CUB and sushi multiple domains protein 1).

SELPL_MOUSE
NC score	0.008005 (rank : 242)	θ value	3.0926 (rank : 169)
Query Neighborhood Hits	227	Target Neighborhood Hits	588	Shared Neighborhood Hits	12
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

MLL2_HUMAN
NC score	0.006762 (rank : 243)	θ value	5.27518 (rank : 187)
Query Neighborhood Hits	227	Target Neighborhood Hits	1788	Shared Neighborhood Hits	39
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

FOXO1_HUMAN
NC score	0.006409 (rank : 244)	θ value	0.62314 (rank : 125)
Query Neighborhood Hits	227	Target Neighborhood Hits	126	Shared Neighborhood Hits	2
SwissProt Accessions	Q12778, O43523, Q5VYC7, Q6NSK6	Gene names	FOXO1A, FKHR
Domain Architecture
Description	Forkhead box protein O1A (Forkhead in rhabdomyosarcoma).

PCLO_MOUSE
NC score	0.005955 (rank : 245)	θ value	0.47712 (rank : 123)
Query Neighborhood Hits	227	Target Neighborhood Hits	2275	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

S35B1_HUMAN
NC score	0.005576 (rank : 246)	θ value	6.88961 (rank : 210)
Query Neighborhood Hits	227	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	P78383, Q96EW7	Gene names	SLC35B1, UGTREL1
Domain Architecture	No domain graphic available
Description	Solute carrier family 35 member B1 (UDP-galactose transporter-related protein 1) (UGTrel1) (hUGTrel1).

PCMD2_HUMAN
NC score	0.005069 (rank : 247)	θ value	6.88961 (rank : 208)
Query Neighborhood Hits	227	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NV79, Q8IW60, Q9H4K2	Gene names	PCMTD2, C20orf36
Domain Architecture
Description	Protein-L-isoaspartate O-methyltransferase domain-containing protein 2.

UBXD1_MOUSE
NC score	0.004953 (rank : 248)	θ value	8.99809 (rank : 227)
Query Neighborhood Hits	227	Target Neighborhood Hits	40	Shared Neighborhood Hits	2
SwissProt Accessions	Q99PL6, Q91W79	Gene names	Ubxd1, Ubxdc2
Domain Architecture
Description	UBX domain-containing protein 1.

CO039_HUMAN
NC score	0.004787 (rank : 249)	θ value	8.99809 (rank : 216)
Query Neighborhood Hits	227	Target Neighborhood Hits	264	Shared Neighborhood Hits	10
SwissProt Accessions	Q6ZRI6, Q71JB1, Q7L3S0, Q8N3F2, Q96FB6, Q9NTU5	Gene names	C15orf39
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C15orf39.

WNT2_HUMAN
NC score	0.004603 (rank : 250)	θ value	0.813845 (rank : 135)
Query Neighborhood Hits	227	Target Neighborhood Hits	47	Shared Neighborhood Hits	3
SwissProt Accessions	P09544, Q75N05, Q9UDP9	Gene names	WNT2, IRP
Domain Architecture
Description	Protein Wnt-2 precursor (IRP protein) (Int-1-related protein).

PARC_HUMAN
NC score	0.004566 (rank : 251)	θ value	4.03905 (rank : 181)
Query Neighborhood Hits	227	Target Neighborhood Hits	148	Shared Neighborhood Hits	6
SwissProt Accessions	Q8IWT3, O75188, Q68CP2, Q68D92, Q8N3W9, Q9BU56	Gene names	PARC, H7AP1, KIAA0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein (UbcH7-associated protein 1).

DIDO1_HUMAN
NC score	0.004498 (rank : 252)	θ value	3.0926 (rank : 164)
Query Neighborhood Hits	227	Target Neighborhood Hits	960	Shared Neighborhood Hits	17
SwissProt Accessions	Q9BTC0, O15043, Q3ZTL7, Q3ZTL8, Q4VXS1, Q4VXS2, Q96D72, Q9BQW0, Q9BW03, Q9H4G6, Q9H4G7, Q9NTU8, Q9NUM8, Q9UFB6	Gene names	DIDO1, C20orf158, DATF1, KIAA0333
Domain Architecture
Description	Death-inducer obliterator 1 (DIO-1) (Death-associated transcription factor 1) (DATF-1) (hDido1).

GNDS_HUMAN
NC score	0.004473 (rank : 253)	θ value	4.03905 (rank : 174)
Query Neighborhood Hits	227	Target Neighborhood Hits	201	Shared Neighborhood Hits	9
SwissProt Accessions	Q12967, Q9HAX7, Q9HAY1, Q9HCT1	Gene names	RALGDS, RGF
Domain Architecture
Description	Ral guanine nucleotide dissociation stimulator (RalGEF) (RalGDS).

TRI47_MOUSE
NC score	0.003962 (rank : 254)	θ value	2.36792 (rank : 162)
Query Neighborhood Hits	227	Target Neighborhood Hits	295	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C0E3, Q6P249, Q811J7, Q8BVZ8, Q8R1K0, Q8R3Y1	Gene names	Trim47
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47.

APOA_HUMAN
NC score	0.003924 (rank : 255)	θ value	8.99809 (rank : 214)
Query Neighborhood Hits	227	Target Neighborhood Hits	221	Shared Neighborhood Hits	8
SwissProt Accessions	P08519	Gene names	LPA
Domain Architecture
Description	Apolipoprotein(a) precursor (EC 3.4.21.-) (Apo(a)) (Lp(a)).

TRI47_HUMAN
NC score	0.002851 (rank : 256)	θ value	8.99809 (rank : 226)
Query Neighborhood Hits	227	Target Neighborhood Hits	286	Shared Neighborhood Hits	6
SwissProt Accessions	Q96LD4, Q96GU5, Q9BRN7	Gene names	TRIM47, GOA, RNF100
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47 (Gene overexpressed in astrocytoma protein) (RING finger protein 100).

WNT2_MOUSE
NC score	0.002602 (rank : 257)	θ value	6.88961 (rank : 213)
Query Neighborhood Hits	227	Target Neighborhood Hits	44	Shared Neighborhood Hits	3
SwissProt Accessions	P21552	Gene names	Wnt2, Irp, Wnt-2
Domain Architecture	No domain graphic available
Description	Protein Wnt-2 precursor (IRP protein) (INT-1-related protein).

STA13_MOUSE
NC score	0.002334 (rank : 258)	θ value	5.27518 (rank : 194)
Query Neighborhood Hits	227	Target Neighborhood Hits	89	Shared Neighborhood Hits	3
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

B3AT_MOUSE
NC score	0.002069 (rank : 259)	θ value	6.88961 (rank : 197)
Query Neighborhood Hits	227	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	P04919	Gene names	Slc4a1, Ae1
Domain Architecture
Description	Band 3 anion transport protein (Anion exchange protein 1) (AE 1) (Solute carrier family 4 member 1) (MEB3) (CD233 antigen).

MAP4_MOUSE
NC score	0.002006 (rank : 260)	θ value	8.99809 (rank : 223)
Query Neighborhood Hits	227	Target Neighborhood Hits	409	Shared Neighborhood Hits	9
SwissProt Accessions	P27546	Gene names	Map4, Mtap4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

HGFL_MOUSE
NC score	0.000938 (rank : 261)	θ value	1.06291 (rank : 137)
Query Neighborhood Hits	227	Target Neighborhood Hits	188	Shared Neighborhood Hits	4
SwissProt Accessions	P26928	Gene names	Mst1, Hgfl
Domain Architecture
Description	Hepatocyte growth factor-like protein precursor (Macrophage stimulatory protein) (MSP) [Contains: Hepatocyte growth factor-like protein alpha chain; Hepatocyte growth factor-like protein beta chain].

DGKI_HUMAN
NC score	0.000276 (rank : 262)	θ value	5.27518 (rank : 185)
Query Neighborhood Hits	227	Target Neighborhood Hits	609	Shared Neighborhood Hits	8
SwissProt Accessions	O75912, Q9NZ49	Gene names	DGKI
Domain Architecture
Description	Diacylglycerol kinase iota (EC 2.7.1.107) (Diglyceride kinase iota) (DGK-iota) (DAG kinase iota).

PTN23_MOUSE
NC score	-0.000595 (rank : 263)	θ value	5.27518 (rank : 192)
Query Neighborhood Hits	227	Target Neighborhood Hits	726	Shared Neighborhood Hits	10
SwissProt Accessions	Q6PB44, Q69ZJ0, Q8R1Z5, Q923E6	Gene names	Ptpn23, Kiaa1471
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48).

KLF10_HUMAN
NC score	-0.004852 (rank : 264)	θ value	2.36792 (rank : 157)
Query Neighborhood Hits	227	Target Neighborhood Hits	744	Shared Neighborhood Hits	7
SwissProt Accessions	Q13118	Gene names	KLF10, TIEG, TIEG1
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 10 (Transforming growth factor-beta-inducible early growth response protein 1) (TGFB-inducible early growth response protein 1) (TIEG-1) (EGR-alpha).

KLF10_MOUSE
NC score	-0.005152 (rank : 265)	θ value	4.03905 (rank : 175)
Query Neighborhood Hits	227	Target Neighborhood Hits	741	Shared Neighborhood Hits	6
SwissProt Accessions	O89091	Gene names	Klf10, Gdnfif, Tieg, Tieg1
Domain Architecture	No domain graphic available
Description	Krueppel-like factor 10 (Transforming growth factor-beta-inducible early growth response protein 1) (TGFB-inducible early growth response protein 1) (TIEG-1) (GDNF-inducible factor) (Transcription factor GIF) (mGIF).

FIZ1_HUMAN
NC score	-0.005205 (rank : 266)	θ value	0.62314 (rank : 124)
Query Neighborhood Hits	227	Target Neighborhood Hits	715	Shared Neighborhood Hits	9
SwissProt Accessions	Q96SL8, Q6ZMJ7	Gene names	FIZ1
Domain Architecture	No domain graphic available
Description	Flt3-interacting zinc finger protein 1.

GLI1_HUMAN
NC score	-0.005647 (rank : 267)	θ value	8.99809 (rank : 219)
Query Neighborhood Hits	227	Target Neighborhood Hits	828	Shared Neighborhood Hits	12
SwissProt Accessions	P08151, Q8TDN9	Gene names	GLI1, GLI
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI1 (Glioma-associated oncogene) (Oncogene GLI).

FIZ1_MOUSE
NC score	-0.006024 (rank : 268)	θ value	6.88961 (rank : 200)
Query Neighborhood Hits	227	Target Neighborhood Hits	715	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WTJ4, Q91W14, Q9CTG3	Gene names	Fiz1
Domain Architecture	No domain graphic available
Description	Flt3-interacting zinc finger protein 1.

AATK_MOUSE
NC score	-0.006121 (rank : 269)	θ value	4.03905 (rank : 171)
Query Neighborhood Hits	227	Target Neighborhood Hits	942	Shared Neighborhood Hits	6
SwissProt Accessions	Q80YE4, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q8CB63, Q8CHE2	Gene names	Aatk, Kiaa0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase).