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Network neighborhood for query Sequence : MMP24_HUMAN

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MMP24_HUMAN
SwissProt Accessions	Q9Y5R2, Q9H440	Gene names	MMP24, MT5MMP
Domain Architecture
Description	Matrix metalloproteinase-24 precursor (EC 3.4.24.-) (MMP-24) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MMP15_HUMAN
θ value	0 (rank : 1)	NC score	0.992315 (rank : 8)
Query Neighborhood Hits	66	Target Neighborhood Hits	95	Shared Neighborhood Hits	48
SwissProt Accessions	P51511, Q14111	Gene names	MMP15
Domain Architecture
Description	Matrix metalloproteinase-15 precursor (EC 3.4.24.-) (MMP-15) (Membrane-type matrix metalloproteinase 2) (MT-MMP 2) (MTMMP2) (Membrane-type-2 matrix metalloproteinase) (MT2-MMP) (MT2MMP) (SMCP- 2).

MMP15_MOUSE
θ value	0 (rank : 2)	NC score	0.994072 (rank : 7)
Query Neighborhood Hits	66	Target Neighborhood Hits	102	Shared Neighborhood Hits	50
SwissProt Accessions	O54732	Gene names	Mmp15
Domain Architecture
Description	Matrix metalloproteinase-15 precursor (EC 3.4.24.-) (MMP-15) (Membrane-type matrix metalloproteinase 2) (MT-MMP 2) (MTMMP2) (Membrane-type-2 matrix metalloproteinase) (MT2-MMP) (MT2MMP).

MMP16_HUMAN
θ value	0 (rank : 3)	NC score	0.997799 (rank : 3)
Query Neighborhood Hits	66	Target Neighborhood Hits	68	Shared Neighborhood Hits	53
SwissProt Accessions	P51512, Q14824, Q52H48	Gene names	MMP16, MMPX2
Domain Architecture
Description	Matrix metalloproteinase-16 precursor (EC 3.4.24.-) (MMP-16) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP) (MMP- X2).

MMP16_MOUSE
θ value	0 (rank : 4)	NC score	0.997727 (rank : 4)
Query Neighborhood Hits	66	Target Neighborhood Hits	72	Shared Neighborhood Hits	53
SwissProt Accessions	Q9WTR0, Q9ERT6	Gene names	Mmp16
Domain Architecture
Description	Matrix metalloproteinase-16 precursor (EC 3.4.24.-) (MMP-16) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP).

MMP24_HUMAN
θ value	0 (rank : 5)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	66	Target Neighborhood Hits	66	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Y5R2, Q9H440	Gene names	MMP24, MT5MMP
Domain Architecture
Description	Matrix metalloproteinase-24 precursor (EC 3.4.24.-) (MMP-24) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP).

MMP24_MOUSE
θ value	0 (rank : 6)	NC score	0.999031 (rank : 2)
Query Neighborhood Hits	66	Target Neighborhood Hits	71	Shared Neighborhood Hits	65
SwissProt Accessions	Q9R0S2, Q9Z0J9	Gene names	Mmp24, Mmp21, Mt5mmp
Domain Architecture
Description	Matrix metalloproteinase-24 precursor (EC 3.4.24.-) (MMP-24) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP) (MMP-21).

MMP14_HUMAN
θ value	2.83983e-179 (rank : 7)	NC score	0.996719 (rank : 5)
Query Neighborhood Hits	66	Target Neighborhood Hits	60	Shared Neighborhood Hits	54
SwissProt Accessions	P50281, Q92678	Gene names	MMP14
Domain Architecture
Description	Matrix metalloproteinase-14 precursor (EC 3.4.24.80) (MMP-14) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP) (MMP- X1).

MMP14_MOUSE
θ value	6.99473e-178 (rank : 8)	NC score	0.996578 (rank : 6)
Query Neighborhood Hits	66	Target Neighborhood Hits	57	Shared Neighborhood Hits	50
SwissProt Accessions	P53690, O08645, O35369	Gene names	Mmp14, Mtmmp
Domain Architecture
Description	Matrix metalloproteinase-14 precursor (EC 3.4.24.80) (MMP-14) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP) (MMP-X1) (MT-MMP).

MMP17_MOUSE
θ value	1.3939e-101 (rank : 9)	NC score	0.984495 (rank : 10)
Query Neighborhood Hits	66	Target Neighborhood Hits	60	Shared Neighborhood Hits	48
SwissProt Accessions	Q9R0S3	Gene names	Mmp17, Mt4mmp
Domain Architecture
Description	Matrix metalloproteinase-17 precursor (EC 3.4.24.-) (MMP-17) (Membrane-type matrix metalloproteinase 4) (MT-MMP 4) (Membrane-type-4 matrix metalloproteinase) (MT4-MMP).

MMP25_HUMAN
θ value	2.72037e-97 (rank : 10)	NC score	0.987235 (rank : 9)
Query Neighborhood Hits	66	Target Neighborhood Hits	56	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NPA2, Q9H3Q0	Gene names	MMP25, MT6MMP
Domain Architecture
Description	Matrix metalloproteinase-25 precursor (EC 3.4.24.-) (MMP-25) (Membrane-type matrix metalloproteinase 6) (MT-MMP 6) (Membrane-type-6 matrix metalloproteinase) (MT6-MMP) (Leukolysin).

MMP17_HUMAN
θ value	3.00772e-96 (rank : 11)	NC score	0.983841 (rank : 11)
Query Neighborhood Hits	66	Target Neighborhood Hits	56	Shared Neighborhood Hits	48
SwissProt Accessions	Q9ULZ9, Q14850	Gene names	MMP17, MT4MMP
Domain Architecture
Description	Matrix metalloproteinase-17 precursor (EC 3.4.24.-) (MMP-17) (Membrane-type matrix metalloproteinase 4) (MT-MMP 4) (Membrane-type-4 matrix metalloproteinase) (MT4-MMP).

MMP12_HUMAN
θ value	1.76739e-88 (rank : 12)	NC score	0.973314 (rank : 15)
Query Neighborhood Hits	66	Target Neighborhood Hits	57	Shared Neighborhood Hits	49
SwissProt Accessions	P39900	Gene names	MMP12, HME
Domain Architecture
Description	Macrophage metalloelastase precursor (EC 3.4.24.65) (HME) (Matrix metalloproteinase-12) (MMP-12) (Macrophage elastase) (ME).

MMP11_MOUSE
θ value	1.2666e-86 (rank : 13)	NC score	0.980912 (rank : 13)
Query Neighborhood Hits	66	Target Neighborhood Hits	53	Shared Neighborhood Hits	47
SwissProt Accessions	Q02853	Gene names	Mmp11
Domain Architecture
Description	Stromelysin-3 precursor (EC 3.4.24.-) (ST3) (SL-3) (Matrix metalloproteinase-11) (MMP-11).

MMP8_HUMAN
θ value	4.81303e-86 (rank : 14)	NC score	0.971933 (rank : 17)
Query Neighborhood Hits	66	Target Neighborhood Hits	54	Shared Neighborhood Hits	48
SwissProt Accessions	P22894, Q45F99	Gene names	MMP8, CLG1
Domain Architecture
Description	Neutrophil collagenase precursor (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (PMNL collagenase) (PMNL-CL).

MMP11_HUMAN
θ value	3.81361e-83 (rank : 15)	NC score	0.981000 (rank : 12)
Query Neighborhood Hits	66	Target Neighborhood Hits	65	Shared Neighborhood Hits	50
SwissProt Accessions	P24347, Q5FX24, Q6PEZ6, Q9UC26	Gene names	MMP11, STMY3
Domain Architecture
Description	Stromelysin-3 precursor (EC 3.4.24.-) (ST3) (SL-3) (Matrix metalloproteinase-11) (MMP-11).

MMP8_MOUSE
θ value	4.98072e-83 (rank : 16)	NC score	0.972498 (rank : 16)
Query Neighborhood Hits	66	Target Neighborhood Hits	57	Shared Neighborhood Hits	49
SwissProt Accessions	O70138, O88733	Gene names	Mmp8
Domain Architecture
Description	Neutrophil collagenase precursor (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (Collagenase 2).

MMP10_MOUSE
θ value	2.73302e-81 (rank : 17)	NC score	0.968775 (rank : 24)
Query Neighborhood Hits	66	Target Neighborhood Hits	57	Shared Neighborhood Hits	47
SwissProt Accessions	O55123	Gene names	Mmp10
Domain Architecture
Description	Stromelysin-2 precursor (EC 3.4.24.22) (Matrix metalloproteinase-10) (MMP-10) (Transin-2) (SL-2).

MMP1_HUMAN
θ value	7.95186e-81 (rank : 18)	NC score	0.967631 (rank : 26)
Query Neighborhood Hits	66	Target Neighborhood Hits	55	Shared Neighborhood Hits	47
SwissProt Accessions	P03956, P08156	Gene names	MMP1, CLG
Domain Architecture
Description	Interstitial collagenase precursor (EC 3.4.24.7) (Matrix metalloproteinase-1) (MMP-1) (Fibroblast collagenase) [Contains: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase].

MMP13_HUMAN
θ value	4.36332e-79 (rank : 19)	NC score	0.969918 (rank : 20)
Query Neighborhood Hits	66	Target Neighborhood Hits	60	Shared Neighborhood Hits	51
SwissProt Accessions	P45452	Gene names	MMP13
Domain Architecture
Description	Collagenase 3 precursor (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13).

MMP20_HUMAN
θ value	3.69378e-78 (rank : 20)	NC score	0.969500 (rank : 21)
Query Neighborhood Hits	66	Target Neighborhood Hits	56	Shared Neighborhood Hits	49
SwissProt Accessions	O60882, Q6DKT9	Gene names	MMP20
Domain Architecture
Description	Matrix metalloproteinase-20 precursor (EC 3.4.24.-) (MMP-20) (Enamel metalloproteinase) (Enamelysin).

MMP10_HUMAN
θ value	4.82422e-78 (rank : 21)	NC score	0.966513 (rank : 30)
Query Neighborhood Hits	66	Target Neighborhood Hits	50	Shared Neighborhood Hits	47
SwissProt Accessions	P09238	Gene names	MMP10, STMY2
Domain Architecture
Description	Stromelysin-2 precursor (EC 3.4.24.22) (Matrix metalloproteinase-10) (MMP-10) (Transin-2) (SL-2).

MMP3_HUMAN
θ value	4.82422e-78 (rank : 22)	NC score	0.966704 (rank : 29)
Query Neighborhood Hits	66	Target Neighborhood Hits	50	Shared Neighborhood Hits	48
SwissProt Accessions	P08254, Q3B7S0	Gene names	MMP3, STMY1
Domain Architecture
Description	Stromelysin-1 precursor (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1) (SL-1).

MMP3_MOUSE
θ value	4.82422e-78 (rank : 23)	NC score	0.967542 (rank : 28)
Query Neighborhood Hits	66	Target Neighborhood Hits	53	Shared Neighborhood Hits	49
SwissProt Accessions	P28862	Gene names	Mmp3
Domain Architecture
Description	Stromelysin-1 precursor (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1) (SL-1) (EMS-2).

MMP13_MOUSE
θ value	4.08394e-77 (rank : 24)	NC score	0.968250 (rank : 25)
Query Neighborhood Hits	66	Target Neighborhood Hits	56	Shared Neighborhood Hits	51
SwissProt Accessions	P33435	Gene names	Mmp13
Domain Architecture
Description	Collagenase 3 precursor (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13).

MMP20_MOUSE
θ value	6.96618e-77 (rank : 25)	NC score	0.969279 (rank : 22)
Query Neighborhood Hits	66	Target Neighborhood Hits	56	Shared Neighborhood Hits	49
SwissProt Accessions	P57748	Gene names	Mmp20
Domain Architecture
Description	Matrix metalloproteinase-20 precursor (EC 3.4.24.-) (MMP-20) (Enamel metalloproteinase) (Enamelysin).

MMP1A_MOUSE
θ value	4.22625e-74 (rank : 26)	NC score	0.967563 (rank : 27)
Query Neighborhood Hits	66	Target Neighborhood Hits	58	Shared Neighborhood Hits	51
SwissProt Accessions	Q9EPL5	Gene names	Mmp1a, McolA
Domain Architecture	No domain graphic available
Description	Interstitial collagenase A precursor (EC 3.4.24.7) (Matrix metalloproteinase-1a) (MMP-1a) (Mcol-A).

MMP12_MOUSE
θ value	2.56397e-71 (rank : 27)	NC score	0.969030 (rank : 23)
Query Neighborhood Hits	66	Target Neighborhood Hits	56	Shared Neighborhood Hits	50
SwissProt Accessions	P34960, Q8BJ92, Q8BJB3, Q8BJB6, Q8BJB8, Q8BJB9, Q8VED6	Gene names	Mmp12, Mme, Mmel
Domain Architecture
Description	Macrophage metalloelastase precursor (EC 3.4.24.65) (MME) (Matrix metalloproteinase-12) (MMP-12).

MMP1B_MOUSE
θ value	1.31681e-67 (rank : 28)	NC score	0.965275 (rank : 31)
Query Neighborhood Hits	66	Target Neighborhood Hits	64	Shared Neighborhood Hits	50
SwissProt Accessions	Q9EPL6	Gene names	Mmp1b, McolB
Domain Architecture	No domain graphic available
Description	Interstitial collagenase B precursor (EC 3.4.24.7) (Matrix metalloproteinase-1b) (MMP-1b) (Mcol-B).

MMP19_HUMAN
θ value	1.45591e-66 (rank : 29)	NC score	0.969928 (rank : 19)
Query Neighborhood Hits	66	Target Neighborhood Hits	51	Shared Neighborhood Hits	46
SwissProt Accessions	Q99542, O15278, O95606, Q99580	Gene names	MMP19, MMP18, RASI
Domain Architecture
Description	Matrix metalloproteinase-19 precursor (EC 3.4.24.-) (MMP-19) (Matrix metalloproteinase RASI) (MMP-18).

MMP19_MOUSE
θ value	3.58603e-65 (rank : 30)	NC score	0.970882 (rank : 18)
Query Neighborhood Hits	66	Target Neighborhood Hits	56	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JHI0, Q8C360	Gene names	Mmp19, Rasi
Domain Architecture
Description	Matrix metalloproteinase-19 precursor (EC 3.4.24.-) (MMP-19) (Matrix metalloproteinase RASI).

MMP28_HUMAN
θ value	3.71096e-62 (rank : 31)	NC score	0.976010 (rank : 14)
Query Neighborhood Hits	66	Target Neighborhood Hits	55	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H239, Q96TE2	Gene names	MMP28, MMP25
Domain Architecture
Description	Matrix metalloproteinase-28 precursor (EC 3.4.24.-) (MMP-28) (Epilysin).

MMP2_MOUSE
θ value	3.1488e-53 (rank : 32)	NC score	0.891737 (rank : 37)
Query Neighborhood Hits	66	Target Neighborhood Hits	77	Shared Neighborhood Hits	52
SwissProt Accessions	P33434	Gene names	Mmp2
Domain Architecture
Description	72 kDa type IV collagenase precursor (EC 3.4.24.24) (72 kDa gelatinase) (Matrix metalloproteinase-2) (MMP-2) (Gelatinase A).

MMP2_HUMAN
θ value	4.11246e-53 (rank : 33)	NC score	0.891499 (rank : 38)
Query Neighborhood Hits	66	Target Neighborhood Hits	79	Shared Neighborhood Hits	52
SwissProt Accessions	P08253	Gene names	MMP2, CLG4A
Domain Architecture
Description	72 kDa type IV collagenase precursor (EC 3.4.24.24) (72 kDa gelatinase) (Matrix metalloproteinase-2) (MMP-2) (Gelatinase A) (TBE- 1).

MMP7_HUMAN
θ value	2.041e-52 (rank : 34)	NC score	0.958672 (rank : 32)
Query Neighborhood Hits	66	Target Neighborhood Hits	49	Shared Neighborhood Hits	43
SwissProt Accessions	P09237, Q9BTK9	Gene names	MMP7, MPSL1, PUMP1
Domain Architecture
Description	Matrilysin precursor (EC 3.4.24.23) (Pump-1 protease) (Uterine metalloproteinase) (Matrix metalloproteinase-7) (MMP-7) (Matrin).

MMP7_MOUSE
θ value	8.30557e-46 (rank : 35)	NC score	0.955473 (rank : 33)
Query Neighborhood Hits	66	Target Neighborhood Hits	60	Shared Neighborhood Hits	43
SwissProt Accessions	Q10738	Gene names	Mmp7
Domain Architecture
Description	Matrilysin precursor (EC 3.4.24.23) (Pump-1 protease) (Uterine metalloproteinase) (Matrix metalloproteinase-7) (MMP-7) (Matrin).

MMP21_HUMAN
θ value	3.86705e-35 (rank : 36)	NC score	0.925001 (rank : 35)
Query Neighborhood Hits	66	Target Neighborhood Hits	76	Shared Neighborhood Hits	50
SwissProt Accessions	Q8N119, Q8NG02	Gene names	MMP21
Domain Architecture	No domain graphic available
Description	Matrix metalloproteinase-21 precursor (EC 3.4.24.-) (MMP-21).

MMP26_HUMAN
θ value	3.27365e-34 (rank : 37)	NC score	0.952093 (rank : 34)
Query Neighborhood Hits	66	Target Neighborhood Hits	56	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NRE1, Q9GZS2, Q9NR87	Gene names	MMP26
Domain Architecture
Description	Matrix metalloproteinase-26 precursor (EC 3.4.24.-) (MMP-26) (Matrilysin-2) (Endometase).

MMP21_MOUSE
θ value	1.6247e-33 (rank : 38)	NC score	0.923627 (rank : 36)
Query Neighborhood Hits	66	Target Neighborhood Hits	59	Shared Neighborhood Hits	50
SwissProt Accessions	Q8K3F2	Gene names	Mmp21
Domain Architecture	No domain graphic available
Description	Matrix metalloproteinase-21 precursor (EC 3.4.24.-) (MMP-21).

MMP9_HUMAN
θ value	8.3442e-30 (rank : 39)	NC score	0.847625 (rank : 39)
Query Neighborhood Hits	66	Target Neighborhood Hits	125	Shared Neighborhood Hits	52
SwissProt Accessions	P14780, Q3LR70, Q8N725, Q9H4Z1	Gene names	MMP9, CLG4B
Domain Architecture
Description	Matrix metalloproteinase-9 precursor (EC 3.4.24.35) (MMP-9) (92 kDa type IV collagenase) (92 kDa gelatinase) (Gelatinase B) (GELB) [Contains: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9].

MMP9_MOUSE
θ value	1.57365e-28 (rank : 40)	NC score	0.837171 (rank : 40)
Query Neighborhood Hits	66	Target Neighborhood Hits	151	Shared Neighborhood Hits	52
SwissProt Accessions	P41245, Q06788, Q9DC02	Gene names	Mmp9, Clg4b
Domain Architecture
Description	Matrix metalloproteinase-9 precursor (EC 3.4.24.35) (MMP-9) (92 kDa type IV collagenase) (92 kDa gelatinase) (Gelatinase B) (GELB).

VTNC_MOUSE
θ value	2.7842e-17 (rank : 41)	NC score	0.746378 (rank : 41)
Query Neighborhood Hits	66	Target Neighborhood Hits	74	Shared Neighborhood Hits	43
SwissProt Accessions	P29788, Q8VII4	Gene names	Vtn
Domain Architecture
Description	Vitronectin precursor (Serum-spreading factor) (S-protein).

VTNC_HUMAN
θ value	2.20605e-14 (rank : 42)	NC score	0.718693 (rank : 42)
Query Neighborhood Hits	66	Target Neighborhood Hits	66	Shared Neighborhood Hits	43
SwissProt Accessions	P04004, P01141, Q9BSH7	Gene names	VTN
Domain Architecture
Description	Vitronectin precursor (Serum-spreading factor) (S-protein) (V75) [Contains: Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin B].

HEMO_HUMAN
θ value	2.36244e-08 (rank : 43)	NC score	0.670246 (rank : 43)
Query Neighborhood Hits	66	Target Neighborhood Hits	47	Shared Neighborhood Hits	43
SwissProt Accessions	P02790	Gene names	HPX
Domain Architecture
Description	Hemopexin precursor (Beta-1B-glycoprotein).

PRG4_MOUSE
θ value	3.41135e-07 (rank : 44)	NC score	0.375900 (rank : 45)
Query Neighborhood Hits	66	Target Neighborhood Hits	624	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

HEMO_MOUSE
θ value	1.09739e-05 (rank : 45)	NC score	0.595420 (rank : 44)
Query Neighborhood Hits	66	Target Neighborhood Hits	48	Shared Neighborhood Hits	43
SwissProt Accessions	Q91X72, P97824, Q8WUP0	Gene names	Hpx, Hpxn
Domain Architecture
Description	Hemopexin precursor.

PRG4_HUMAN
θ value	0.000461057 (rank : 46)	NC score	0.307980 (rank : 46)
Query Neighborhood Hits	66	Target Neighborhood Hits	764	Shared Neighborhood Hits	45
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

ES8L2_HUMAN
θ value	0.0736092 (rank : 47)	NC score	0.023835 (rank : 52)
Query Neighborhood Hits	66	Target Neighborhood Hits	193	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ATS13_HUMAN
θ value	1.06291 (rank : 48)	NC score	0.058740 (rank : 49)
Query Neighborhood Hits	66	Target Neighborhood Hits	238	Shared Neighborhood Hits	44
SwissProt Accessions	Q76LX8, Q6UY16, Q710F6, Q711T8, Q96L37, Q9H0G3	Gene names	ADAMTS13, C9orf8
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

NID1_MOUSE
θ value	1.06291 (rank : 49)	NC score	0.004400 (rank : 65)
Query Neighborhood Hits	66	Target Neighborhood Hits	335	Shared Neighborhood Hits	5
SwissProt Accessions	P10493, Q8BQI3, Q8C3U8, Q8C9P6	Gene names	Nid1, Ent
Domain Architecture
Description	Nidogen-1 precursor (Entactin).

ES8L2_MOUSE
θ value	1.38821 (rank : 50)	NC score	0.017733 (rank : 55)
Query Neighborhood Hits	66	Target Neighborhood Hits	169	Shared Neighborhood Hits	5
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

SON_HUMAN
θ value	1.38821 (rank : 51)	NC score	0.007286 (rank : 62)
Query Neighborhood Hits	66	Target Neighborhood Hits	1568	Shared Neighborhood Hits	9
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

CC025_HUMAN
θ value	2.36792 (rank : 52)	NC score	0.021245 (rank : 53)
Query Neighborhood Hits	66	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q6NXP0, Q69YX4	Gene names	C3orf25
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf25.

ADA15_MOUSE
θ value	4.03905 (rank : 53)	NC score	0.007820 (rank : 61)
Query Neighborhood Hits	66	Target Neighborhood Hits	324	Shared Neighborhood Hits	19
SwissProt Accessions	O88839, Q3U7C2, Q8C7Z0, Q91VS9, Q9QYL2	Gene names	Adam15, Mdc15
Domain Architecture
Description	ADAM 15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 15) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein 15) (MDC-15) (Metalloprotease RGD disintegrin protein) (Metargidin) (AD56).

ATS13_MOUSE
θ value	4.03905 (rank : 54)	NC score	0.042614 (rank : 50)
Query Neighborhood Hits	66	Target Neighborhood Hits	227	Shared Neighborhood Hits	40
SwissProt Accessions	Q769J6, Q76LW1	Gene names	Adamts13
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

ES8L3_HUMAN
θ value	4.03905 (rank : 55)	NC score	0.012767 (rank : 60)
Query Neighborhood Hits	66	Target Neighborhood Hits	206	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ADA12_MOUSE
θ value	5.27518 (rank : 56)	NC score	0.004574 (rank : 64)
Query Neighborhood Hits	66	Target Neighborhood Hits	474	Shared Neighborhood Hits	16
SwissProt Accessions	Q61824	Gene names	Adam12, Mltna
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

ADA17_HUMAN
θ value	5.27518 (rank : 57)	NC score	0.016178 (rank : 56)
Query Neighborhood Hits	66	Target Neighborhood Hits	223	Shared Neighborhood Hits	19
SwissProt Accessions	P78536, O60226	Gene names	ADAM17, CSVP, TACE
Domain Architecture
Description	ADAM 17 precursor (EC 3.4.24.86) (A disintegrin and metalloproteinase domain 17) (TNF-alpha-converting enzyme) (TNF-alpha convertase) (Snake venom-like protease) (CD156b antigen).

ADA17_MOUSE
θ value	5.27518 (rank : 58)	NC score	0.019694 (rank : 54)
Query Neighborhood Hits	66	Target Neighborhood Hits	201	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z0F8, O88726, Q9R1U4, Q9Z0K3	Gene names	Adam17, Tace
Domain Architecture
Description	ADAM 17 precursor (EC 3.4.24.86) (A disintegrin and metalloproteinase domain 17) (TNF-alpha-converting enzyme) (TNF-alpha convertase) (CD156b antigen).

ATS17_HUMAN
θ value	5.27518 (rank : 59)	NC score	0.031900 (rank : 51)
Query Neighborhood Hits	66	Target Neighborhood Hits	194	Shared Neighborhood Hits	34
SwissProt Accessions	Q8TE56	Gene names	ADAMTS17
Domain Architecture
Description	ADAMTS-17 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 17) (ADAM-TS 17) (ADAM-TS17).

SNCAP_HUMAN
θ value	5.27518 (rank : 60)	NC score	0.003952 (rank : 66)
Query Neighborhood Hits	66	Target Neighborhood Hits	313	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6H5	Gene names	SNCAIP
Domain Architecture
Description	Synphilin-1 (Alpha-synuclein-interacting protein).

ADA15_HUMAN
θ value	6.88961 (rank : 61)	NC score	0.006311 (rank : 63)
Query Neighborhood Hits	66	Target Neighborhood Hits	288	Shared Neighborhood Hits	15
SwissProt Accessions	Q13444, Q13493, Q96C78	Gene names	ADAM15, MDC15
Domain Architecture
Description	ADAM 15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 15) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein 15) (MDC-15) (Metalloprotease RGD disintegrin protein) (Metargidin).

ATS2_HUMAN
θ value	6.88961 (rank : 62)	NC score	0.015889 (rank : 57)
Query Neighborhood Hits	66	Target Neighborhood Hits	179	Shared Neighborhood Hits	28
SwissProt Accessions	O95450	Gene names	ADAMTS2, PCINP, PCPNI
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

ATS2_MOUSE
θ value	6.88961 (rank : 63)	NC score	0.015386 (rank : 58)
Query Neighborhood Hits	66	Target Neighborhood Hits	179	Shared Neighborhood Hits	27
SwissProt Accessions	Q8C9W3	Gene names	Adamts2
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

ATS3_HUMAN
θ value	8.99809 (rank : 64)	NC score	0.013141 (rank : 59)
Query Neighborhood Hits	66	Target Neighborhood Hits	179	Shared Neighborhood Hits	23
SwissProt Accessions	O15072, Q9BXZ8	Gene names	ADAMTS3, KIAA0366
Domain Architecture
Description	ADAMTS-3 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 3) (ADAM-TS 3) (ADAM-TS3) (Procollagen II amino propeptide-processing enzyme) (Procollagen II N-proteinase) (PC II-NP).

MAGD4_HUMAN
θ value	8.99809 (rank : 65)	NC score	0.000518 (rank : 68)
Query Neighborhood Hits	66	Target Neighborhood Hits	338	Shared Neighborhood Hits	3
SwissProt Accessions	Q96JG8, Q8WXW4, Q9BQ84, Q9BYH3, Q9BYH4	Gene names	MAGED4, KIAA1859, MAGEE1
Domain Architecture
Description	Melanoma-associated antigen D4 (MAGE-D4 antigen) (MAGE-E1 antigen).

SMAL1_MOUSE
θ value	8.99809 (rank : 66)	NC score	0.003004 (rank : 67)
Query Neighborhood Hits	66	Target Neighborhood Hits	157	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BJL0, Q8BVK7, Q8BXW4, Q8K309, Q9EQK8, Q9QYC4	Gene names	Smarcal1, Harp
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (mharp).

SEL1L_HUMAN
θ value	θ > 10 (rank : 67)	NC score	0.069270 (rank : 47)
Query Neighborhood Hits	66	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UBV2, Q6UWT6, Q9P1T9, Q9UHK7	Gene names	SEL1L, TSA305
Domain Architecture
Description	Sel-1 homolog precursor (Suppressor of lin-12-like protein) (Sel-1L).

SEL1L_MOUSE
θ value	θ > 10 (rank : 68)	NC score	0.067529 (rank : 48)
Query Neighborhood Hits	66	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z2G6, Q9DBD8	Gene names	Sel1l, Sel1h
Domain Architecture
Description	Sel-1 homolog precursor (Suppressor of lin-12-like protein) (Sel-1L).

Hits sorted by NC score

MMP24_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 5)
Query Neighborhood Hits	66	Target Neighborhood Hits	66	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Y5R2, Q9H440	Gene names	MMP24, MT5MMP
Domain Architecture
Description	Matrix metalloproteinase-24 precursor (EC 3.4.24.-) (MMP-24) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP).

MMP24_MOUSE
NC score	0.999031 (rank : 2)	θ value	0 (rank : 6)
Query Neighborhood Hits	66	Target Neighborhood Hits	71	Shared Neighborhood Hits	65
SwissProt Accessions	Q9R0S2, Q9Z0J9	Gene names	Mmp24, Mmp21, Mt5mmp
Domain Architecture
Description	Matrix metalloproteinase-24 precursor (EC 3.4.24.-) (MMP-24) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP) (MMP-21).

MMP16_HUMAN
NC score	0.997799 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	66	Target Neighborhood Hits	68	Shared Neighborhood Hits	53
SwissProt Accessions	P51512, Q14824, Q52H48	Gene names	MMP16, MMPX2
Domain Architecture
Description	Matrix metalloproteinase-16 precursor (EC 3.4.24.-) (MMP-16) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP) (MMP- X2).

MMP16_MOUSE
NC score	0.997727 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	66	Target Neighborhood Hits	72	Shared Neighborhood Hits	53
SwissProt Accessions	Q9WTR0, Q9ERT6	Gene names	Mmp16
Domain Architecture
Description	Matrix metalloproteinase-16 precursor (EC 3.4.24.-) (MMP-16) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP).

MMP14_HUMAN
NC score	0.996719 (rank : 5)	θ value	2.83983e-179 (rank : 7)
Query Neighborhood Hits	66	Target Neighborhood Hits	60	Shared Neighborhood Hits	54
SwissProt Accessions	P50281, Q92678	Gene names	MMP14
Domain Architecture
Description	Matrix metalloproteinase-14 precursor (EC 3.4.24.80) (MMP-14) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP) (MMP- X1).

MMP14_MOUSE
NC score	0.996578 (rank : 6)	θ value	6.99473e-178 (rank : 8)
Query Neighborhood Hits	66	Target Neighborhood Hits	57	Shared Neighborhood Hits	50
SwissProt Accessions	P53690, O08645, O35369	Gene names	Mmp14, Mtmmp
Domain Architecture
Description	Matrix metalloproteinase-14 precursor (EC 3.4.24.80) (MMP-14) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP) (MMP-X1) (MT-MMP).

MMP15_MOUSE
NC score	0.994072 (rank : 7)	θ value	0 (rank : 2)
Query Neighborhood Hits	66	Target Neighborhood Hits	102	Shared Neighborhood Hits	50
SwissProt Accessions	O54732	Gene names	Mmp15
Domain Architecture
Description	Matrix metalloproteinase-15 precursor (EC 3.4.24.-) (MMP-15) (Membrane-type matrix metalloproteinase 2) (MT-MMP 2) (MTMMP2) (Membrane-type-2 matrix metalloproteinase) (MT2-MMP) (MT2MMP).

MMP15_HUMAN
NC score	0.992315 (rank : 8)	θ value	0 (rank : 1)
Query Neighborhood Hits	66	Target Neighborhood Hits	95	Shared Neighborhood Hits	48
SwissProt Accessions	P51511, Q14111	Gene names	MMP15
Domain Architecture
Description	Matrix metalloproteinase-15 precursor (EC 3.4.24.-) (MMP-15) (Membrane-type matrix metalloproteinase 2) (MT-MMP 2) (MTMMP2) (Membrane-type-2 matrix metalloproteinase) (MT2-MMP) (MT2MMP) (SMCP- 2).

MMP25_HUMAN
NC score	0.987235 (rank : 9)	θ value	2.72037e-97 (rank : 10)
Query Neighborhood Hits	66	Target Neighborhood Hits	56	Shared Neighborhood Hits	48
SwissProt Accessions	Q9NPA2, Q9H3Q0	Gene names	MMP25, MT6MMP
Domain Architecture
Description	Matrix metalloproteinase-25 precursor (EC 3.4.24.-) (MMP-25) (Membrane-type matrix metalloproteinase 6) (MT-MMP 6) (Membrane-type-6 matrix metalloproteinase) (MT6-MMP) (Leukolysin).

MMP17_MOUSE
NC score	0.984495 (rank : 10)	θ value	1.3939e-101 (rank : 9)
Query Neighborhood Hits	66	Target Neighborhood Hits	60	Shared Neighborhood Hits	48
SwissProt Accessions	Q9R0S3	Gene names	Mmp17, Mt4mmp
Domain Architecture
Description	Matrix metalloproteinase-17 precursor (EC 3.4.24.-) (MMP-17) (Membrane-type matrix metalloproteinase 4) (MT-MMP 4) (Membrane-type-4 matrix metalloproteinase) (MT4-MMP).

MMP17_HUMAN
NC score	0.983841 (rank : 11)	θ value	3.00772e-96 (rank : 11)
Query Neighborhood Hits	66	Target Neighborhood Hits	56	Shared Neighborhood Hits	48
SwissProt Accessions	Q9ULZ9, Q14850	Gene names	MMP17, MT4MMP
Domain Architecture
Description	Matrix metalloproteinase-17 precursor (EC 3.4.24.-) (MMP-17) (Membrane-type matrix metalloproteinase 4) (MT-MMP 4) (Membrane-type-4 matrix metalloproteinase) (MT4-MMP).

MMP11_HUMAN
NC score	0.981000 (rank : 12)	θ value	3.81361e-83 (rank : 15)
Query Neighborhood Hits	66	Target Neighborhood Hits	65	Shared Neighborhood Hits	50
SwissProt Accessions	P24347, Q5FX24, Q6PEZ6, Q9UC26	Gene names	MMP11, STMY3
Domain Architecture
Description	Stromelysin-3 precursor (EC 3.4.24.-) (ST3) (SL-3) (Matrix metalloproteinase-11) (MMP-11).

MMP11_MOUSE
NC score	0.980912 (rank : 13)	θ value	1.2666e-86 (rank : 13)
Query Neighborhood Hits	66	Target Neighborhood Hits	53	Shared Neighborhood Hits	47
SwissProt Accessions	Q02853	Gene names	Mmp11
Domain Architecture
Description	Stromelysin-3 precursor (EC 3.4.24.-) (ST3) (SL-3) (Matrix metalloproteinase-11) (MMP-11).

MMP28_HUMAN
NC score	0.976010 (rank : 14)	θ value	3.71096e-62 (rank : 31)
Query Neighborhood Hits	66	Target Neighborhood Hits	55	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H239, Q96TE2	Gene names	MMP28, MMP25
Domain Architecture
Description	Matrix metalloproteinase-28 precursor (EC 3.4.24.-) (MMP-28) (Epilysin).

MMP12_HUMAN
NC score	0.973314 (rank : 15)	θ value	1.76739e-88 (rank : 12)
Query Neighborhood Hits	66	Target Neighborhood Hits	57	Shared Neighborhood Hits	49
SwissProt Accessions	P39900	Gene names	MMP12, HME
Domain Architecture
Description	Macrophage metalloelastase precursor (EC 3.4.24.65) (HME) (Matrix metalloproteinase-12) (MMP-12) (Macrophage elastase) (ME).

MMP8_MOUSE
NC score	0.972498 (rank : 16)	θ value	4.98072e-83 (rank : 16)
Query Neighborhood Hits	66	Target Neighborhood Hits	57	Shared Neighborhood Hits	49
SwissProt Accessions	O70138, O88733	Gene names	Mmp8
Domain Architecture
Description	Neutrophil collagenase precursor (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (Collagenase 2).

MMP8_HUMAN
NC score	0.971933 (rank : 17)	θ value	4.81303e-86 (rank : 14)
Query Neighborhood Hits	66	Target Neighborhood Hits	54	Shared Neighborhood Hits	48
SwissProt Accessions	P22894, Q45F99	Gene names	MMP8, CLG1
Domain Architecture
Description	Neutrophil collagenase precursor (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (PMNL collagenase) (PMNL-CL).

MMP19_MOUSE
NC score	0.970882 (rank : 18)	θ value	3.58603e-65 (rank : 30)
Query Neighborhood Hits	66	Target Neighborhood Hits	56	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JHI0, Q8C360	Gene names	Mmp19, Rasi
Domain Architecture
Description	Matrix metalloproteinase-19 precursor (EC 3.4.24.-) (MMP-19) (Matrix metalloproteinase RASI).

MMP19_HUMAN
NC score	0.969928 (rank : 19)	θ value	1.45591e-66 (rank : 29)
Query Neighborhood Hits	66	Target Neighborhood Hits	51	Shared Neighborhood Hits	46
SwissProt Accessions	Q99542, O15278, O95606, Q99580	Gene names	MMP19, MMP18, RASI
Domain Architecture
Description	Matrix metalloproteinase-19 precursor (EC 3.4.24.-) (MMP-19) (Matrix metalloproteinase RASI) (MMP-18).

MMP13_HUMAN
NC score	0.969918 (rank : 20)	θ value	4.36332e-79 (rank : 19)
Query Neighborhood Hits	66	Target Neighborhood Hits	60	Shared Neighborhood Hits	51
SwissProt Accessions	P45452	Gene names	MMP13
Domain Architecture
Description	Collagenase 3 precursor (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13).

MMP20_HUMAN
NC score	0.969500 (rank : 21)	θ value	3.69378e-78 (rank : 20)
Query Neighborhood Hits	66	Target Neighborhood Hits	56	Shared Neighborhood Hits	49
SwissProt Accessions	O60882, Q6DKT9	Gene names	MMP20
Domain Architecture
Description	Matrix metalloproteinase-20 precursor (EC 3.4.24.-) (MMP-20) (Enamel metalloproteinase) (Enamelysin).

MMP20_MOUSE
NC score	0.969279 (rank : 22)	θ value	6.96618e-77 (rank : 25)
Query Neighborhood Hits	66	Target Neighborhood Hits	56	Shared Neighborhood Hits	49
SwissProt Accessions	P57748	Gene names	Mmp20
Domain Architecture
Description	Matrix metalloproteinase-20 precursor (EC 3.4.24.-) (MMP-20) (Enamel metalloproteinase) (Enamelysin).

MMP12_MOUSE
NC score	0.969030 (rank : 23)	θ value	2.56397e-71 (rank : 27)
Query Neighborhood Hits	66	Target Neighborhood Hits	56	Shared Neighborhood Hits	50
SwissProt Accessions	P34960, Q8BJ92, Q8BJB3, Q8BJB6, Q8BJB8, Q8BJB9, Q8VED6	Gene names	Mmp12, Mme, Mmel
Domain Architecture
Description	Macrophage metalloelastase precursor (EC 3.4.24.65) (MME) (Matrix metalloproteinase-12) (MMP-12).

MMP10_MOUSE
NC score	0.968775 (rank : 24)	θ value	2.73302e-81 (rank : 17)
Query Neighborhood Hits	66	Target Neighborhood Hits	57	Shared Neighborhood Hits	47
SwissProt Accessions	O55123	Gene names	Mmp10
Domain Architecture
Description	Stromelysin-2 precursor (EC 3.4.24.22) (Matrix metalloproteinase-10) (MMP-10) (Transin-2) (SL-2).

MMP13_MOUSE
NC score	0.968250 (rank : 25)	θ value	4.08394e-77 (rank : 24)
Query Neighborhood Hits	66	Target Neighborhood Hits	56	Shared Neighborhood Hits	51
SwissProt Accessions	P33435	Gene names	Mmp13
Domain Architecture
Description	Collagenase 3 precursor (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13).

MMP1_HUMAN
NC score	0.967631 (rank : 26)	θ value	7.95186e-81 (rank : 18)
Query Neighborhood Hits	66	Target Neighborhood Hits	55	Shared Neighborhood Hits	47
SwissProt Accessions	P03956, P08156	Gene names	MMP1, CLG
Domain Architecture
Description	Interstitial collagenase precursor (EC 3.4.24.7) (Matrix metalloproteinase-1) (MMP-1) (Fibroblast collagenase) [Contains: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase].

MMP1A_MOUSE
NC score	0.967563 (rank : 27)	θ value	4.22625e-74 (rank : 26)
Query Neighborhood Hits	66	Target Neighborhood Hits	58	Shared Neighborhood Hits	51
SwissProt Accessions	Q9EPL5	Gene names	Mmp1a, McolA
Domain Architecture	No domain graphic available
Description	Interstitial collagenase A precursor (EC 3.4.24.7) (Matrix metalloproteinase-1a) (MMP-1a) (Mcol-A).

MMP3_MOUSE
NC score	0.967542 (rank : 28)	θ value	4.82422e-78 (rank : 23)
Query Neighborhood Hits	66	Target Neighborhood Hits	53	Shared Neighborhood Hits	49
SwissProt Accessions	P28862	Gene names	Mmp3
Domain Architecture
Description	Stromelysin-1 precursor (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1) (SL-1) (EMS-2).

MMP3_HUMAN
NC score	0.966704 (rank : 29)	θ value	4.82422e-78 (rank : 22)
Query Neighborhood Hits	66	Target Neighborhood Hits	50	Shared Neighborhood Hits	48
SwissProt Accessions	P08254, Q3B7S0	Gene names	MMP3, STMY1
Domain Architecture
Description	Stromelysin-1 precursor (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1) (SL-1).

MMP10_HUMAN
NC score	0.966513 (rank : 30)	θ value	4.82422e-78 (rank : 21)
Query Neighborhood Hits	66	Target Neighborhood Hits	50	Shared Neighborhood Hits	47
SwissProt Accessions	P09238	Gene names	MMP10, STMY2
Domain Architecture
Description	Stromelysin-2 precursor (EC 3.4.24.22) (Matrix metalloproteinase-10) (MMP-10) (Transin-2) (SL-2).

MMP1B_MOUSE
NC score	0.965275 (rank : 31)	θ value	1.31681e-67 (rank : 28)
Query Neighborhood Hits	66	Target Neighborhood Hits	64	Shared Neighborhood Hits	50
SwissProt Accessions	Q9EPL6	Gene names	Mmp1b, McolB
Domain Architecture	No domain graphic available
Description	Interstitial collagenase B precursor (EC 3.4.24.7) (Matrix metalloproteinase-1b) (MMP-1b) (Mcol-B).

MMP7_HUMAN
NC score	0.958672 (rank : 32)	θ value	2.041e-52 (rank : 34)
Query Neighborhood Hits	66	Target Neighborhood Hits	49	Shared Neighborhood Hits	43
SwissProt Accessions	P09237, Q9BTK9	Gene names	MMP7, MPSL1, PUMP1
Domain Architecture
Description	Matrilysin precursor (EC 3.4.24.23) (Pump-1 protease) (Uterine metalloproteinase) (Matrix metalloproteinase-7) (MMP-7) (Matrin).

MMP7_MOUSE
NC score	0.955473 (rank : 33)	θ value	8.30557e-46 (rank : 35)
Query Neighborhood Hits	66	Target Neighborhood Hits	60	Shared Neighborhood Hits	43
SwissProt Accessions	Q10738	Gene names	Mmp7
Domain Architecture
Description	Matrilysin precursor (EC 3.4.24.23) (Pump-1 protease) (Uterine metalloproteinase) (Matrix metalloproteinase-7) (MMP-7) (Matrin).

MMP26_HUMAN
NC score	0.952093 (rank : 34)	θ value	3.27365e-34 (rank : 37)
Query Neighborhood Hits	66	Target Neighborhood Hits	56	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NRE1, Q9GZS2, Q9NR87	Gene names	MMP26
Domain Architecture
Description	Matrix metalloproteinase-26 precursor (EC 3.4.24.-) (MMP-26) (Matrilysin-2) (Endometase).

MMP21_HUMAN
NC score	0.925001 (rank : 35)	θ value	3.86705e-35 (rank : 36)
Query Neighborhood Hits	66	Target Neighborhood Hits	76	Shared Neighborhood Hits	50
SwissProt Accessions	Q8N119, Q8NG02	Gene names	MMP21
Domain Architecture	No domain graphic available
Description	Matrix metalloproteinase-21 precursor (EC 3.4.24.-) (MMP-21).

MMP21_MOUSE
NC score	0.923627 (rank : 36)	θ value	1.6247e-33 (rank : 38)
Query Neighborhood Hits	66	Target Neighborhood Hits	59	Shared Neighborhood Hits	50
SwissProt Accessions	Q8K3F2	Gene names	Mmp21
Domain Architecture	No domain graphic available
Description	Matrix metalloproteinase-21 precursor (EC 3.4.24.-) (MMP-21).

MMP2_MOUSE
NC score	0.891737 (rank : 37)	θ value	3.1488e-53 (rank : 32)
Query Neighborhood Hits	66	Target Neighborhood Hits	77	Shared Neighborhood Hits	52
SwissProt Accessions	P33434	Gene names	Mmp2
Domain Architecture
Description	72 kDa type IV collagenase precursor (EC 3.4.24.24) (72 kDa gelatinase) (Matrix metalloproteinase-2) (MMP-2) (Gelatinase A).

MMP2_HUMAN
NC score	0.891499 (rank : 38)	θ value	4.11246e-53 (rank : 33)
Query Neighborhood Hits	66	Target Neighborhood Hits	79	Shared Neighborhood Hits	52
SwissProt Accessions	P08253	Gene names	MMP2, CLG4A
Domain Architecture
Description	72 kDa type IV collagenase precursor (EC 3.4.24.24) (72 kDa gelatinase) (Matrix metalloproteinase-2) (MMP-2) (Gelatinase A) (TBE- 1).

MMP9_HUMAN
NC score	0.847625 (rank : 39)	θ value	8.3442e-30 (rank : 39)
Query Neighborhood Hits	66	Target Neighborhood Hits	125	Shared Neighborhood Hits	52
SwissProt Accessions	P14780, Q3LR70, Q8N725, Q9H4Z1	Gene names	MMP9, CLG4B
Domain Architecture
Description	Matrix metalloproteinase-9 precursor (EC 3.4.24.35) (MMP-9) (92 kDa type IV collagenase) (92 kDa gelatinase) (Gelatinase B) (GELB) [Contains: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9].

MMP9_MOUSE
NC score	0.837171 (rank : 40)	θ value	1.57365e-28 (rank : 40)
Query Neighborhood Hits	66	Target Neighborhood Hits	151	Shared Neighborhood Hits	52
SwissProt Accessions	P41245, Q06788, Q9DC02	Gene names	Mmp9, Clg4b
Domain Architecture
Description	Matrix metalloproteinase-9 precursor (EC 3.4.24.35) (MMP-9) (92 kDa type IV collagenase) (92 kDa gelatinase) (Gelatinase B) (GELB).

VTNC_MOUSE
NC score	0.746378 (rank : 41)	θ value	2.7842e-17 (rank : 41)
Query Neighborhood Hits	66	Target Neighborhood Hits	74	Shared Neighborhood Hits	43
SwissProt Accessions	P29788, Q8VII4	Gene names	Vtn
Domain Architecture
Description	Vitronectin precursor (Serum-spreading factor) (S-protein).

VTNC_HUMAN
NC score	0.718693 (rank : 42)	θ value	2.20605e-14 (rank : 42)
Query Neighborhood Hits	66	Target Neighborhood Hits	66	Shared Neighborhood Hits	43
SwissProt Accessions	P04004, P01141, Q9BSH7	Gene names	VTN
Domain Architecture
Description	Vitronectin precursor (Serum-spreading factor) (S-protein) (V75) [Contains: Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin B].

HEMO_HUMAN
NC score	0.670246 (rank : 43)	θ value	2.36244e-08 (rank : 43)
Query Neighborhood Hits	66	Target Neighborhood Hits	47	Shared Neighborhood Hits	43
SwissProt Accessions	P02790	Gene names	HPX
Domain Architecture
Description	Hemopexin precursor (Beta-1B-glycoprotein).

HEMO_MOUSE
NC score	0.595420 (rank : 44)	θ value	1.09739e-05 (rank : 45)
Query Neighborhood Hits	66	Target Neighborhood Hits	48	Shared Neighborhood Hits	43
SwissProt Accessions	Q91X72, P97824, Q8WUP0	Gene names	Hpx, Hpxn
Domain Architecture
Description	Hemopexin precursor.

PRG4_MOUSE
NC score	0.375900 (rank : 45)	θ value	3.41135e-07 (rank : 44)
Query Neighborhood Hits	66	Target Neighborhood Hits	624	Shared Neighborhood Hits	46
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PRG4_HUMAN
NC score	0.307980 (rank : 46)	θ value	0.000461057 (rank : 46)
Query Neighborhood Hits	66	Target Neighborhood Hits	764	Shared Neighborhood Hits	45
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

SEL1L_HUMAN
NC score	0.069270 (rank : 47)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	66	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UBV2, Q6UWT6, Q9P1T9, Q9UHK7	Gene names	SEL1L, TSA305
Domain Architecture
Description	Sel-1 homolog precursor (Suppressor of lin-12-like protein) (Sel-1L).

SEL1L_MOUSE
NC score	0.067529 (rank : 48)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	66	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z2G6, Q9DBD8	Gene names	Sel1l, Sel1h
Domain Architecture
Description	Sel-1 homolog precursor (Suppressor of lin-12-like protein) (Sel-1L).

ATS13_HUMAN
NC score	0.058740 (rank : 49)	θ value	1.06291 (rank : 48)
Query Neighborhood Hits	66	Target Neighborhood Hits	238	Shared Neighborhood Hits	44
SwissProt Accessions	Q76LX8, Q6UY16, Q710F6, Q711T8, Q96L37, Q9H0G3	Gene names	ADAMTS13, C9orf8
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

ATS13_MOUSE
NC score	0.042614 (rank : 50)	θ value	4.03905 (rank : 54)
Query Neighborhood Hits	66	Target Neighborhood Hits	227	Shared Neighborhood Hits	40
SwissProt Accessions	Q769J6, Q76LW1	Gene names	Adamts13
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

ATS17_HUMAN
NC score	0.031900 (rank : 51)	θ value	5.27518 (rank : 59)
Query Neighborhood Hits	66	Target Neighborhood Hits	194	Shared Neighborhood Hits	34
SwissProt Accessions	Q8TE56	Gene names	ADAMTS17
Domain Architecture
Description	ADAMTS-17 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 17) (ADAM-TS 17) (ADAM-TS17).

ES8L2_HUMAN
NC score	0.023835 (rank : 52)	θ value	0.0736092 (rank : 47)
Query Neighborhood Hits	66	Target Neighborhood Hits	193	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

CC025_HUMAN
NC score	0.021245 (rank : 53)	θ value	2.36792 (rank : 52)
Query Neighborhood Hits	66	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	Q6NXP0, Q69YX4	Gene names	C3orf25
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C3orf25.

ADA17_MOUSE
NC score	0.019694 (rank : 54)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	66	Target Neighborhood Hits	201	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z0F8, O88726, Q9R1U4, Q9Z0K3	Gene names	Adam17, Tace
Domain Architecture
Description	ADAM 17 precursor (EC 3.4.24.86) (A disintegrin and metalloproteinase domain 17) (TNF-alpha-converting enzyme) (TNF-alpha convertase) (CD156b antigen).

ES8L2_MOUSE
NC score	0.017733 (rank : 55)	θ value	1.38821 (rank : 50)
Query Neighborhood Hits	66	Target Neighborhood Hits	169	Shared Neighborhood Hits	5
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ADA17_HUMAN
NC score	0.016178 (rank : 56)	θ value	5.27518 (rank : 57)
Query Neighborhood Hits	66	Target Neighborhood Hits	223	Shared Neighborhood Hits	19
SwissProt Accessions	P78536, O60226	Gene names	ADAM17, CSVP, TACE
Domain Architecture
Description	ADAM 17 precursor (EC 3.4.24.86) (A disintegrin and metalloproteinase domain 17) (TNF-alpha-converting enzyme) (TNF-alpha convertase) (Snake venom-like protease) (CD156b antigen).

ATS2_HUMAN
NC score	0.015889 (rank : 57)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	66	Target Neighborhood Hits	179	Shared Neighborhood Hits	28
SwissProt Accessions	O95450	Gene names	ADAMTS2, PCINP, PCPNI
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

ATS2_MOUSE
NC score	0.015386 (rank : 58)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	66	Target Neighborhood Hits	179	Shared Neighborhood Hits	27
SwissProt Accessions	Q8C9W3	Gene names	Adamts2
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

ATS3_HUMAN
NC score	0.013141 (rank : 59)	θ value	8.99809 (rank : 64)
Query Neighborhood Hits	66	Target Neighborhood Hits	179	Shared Neighborhood Hits	23
SwissProt Accessions	O15072, Q9BXZ8	Gene names	ADAMTS3, KIAA0366
Domain Architecture
Description	ADAMTS-3 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 3) (ADAM-TS 3) (ADAM-TS3) (Procollagen II amino propeptide-processing enzyme) (Procollagen II N-proteinase) (PC II-NP).

ES8L3_HUMAN
NC score	0.012767 (rank : 60)	θ value	4.03905 (rank : 55)
Query Neighborhood Hits	66	Target Neighborhood Hits	206	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ADA15_MOUSE
NC score	0.007820 (rank : 61)	θ value	4.03905 (rank : 53)
Query Neighborhood Hits	66	Target Neighborhood Hits	324	Shared Neighborhood Hits	19
SwissProt Accessions	O88839, Q3U7C2, Q8C7Z0, Q91VS9, Q9QYL2	Gene names	Adam15, Mdc15
Domain Architecture
Description	ADAM 15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 15) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein 15) (MDC-15) (Metalloprotease RGD disintegrin protein) (Metargidin) (AD56).

SON_HUMAN
NC score	0.007286 (rank : 62)	θ value	1.38821 (rank : 51)
Query Neighborhood Hits	66	Target Neighborhood Hits	1568	Shared Neighborhood Hits	9
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

ADA15_HUMAN
NC score	0.006311 (rank : 63)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	66	Target Neighborhood Hits	288	Shared Neighborhood Hits	15
SwissProt Accessions	Q13444, Q13493, Q96C78	Gene names	ADAM15, MDC15
Domain Architecture
Description	ADAM 15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 15) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein 15) (MDC-15) (Metalloprotease RGD disintegrin protein) (Metargidin).

ADA12_MOUSE
NC score	0.004574 (rank : 64)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	66	Target Neighborhood Hits	474	Shared Neighborhood Hits	16
SwissProt Accessions	Q61824	Gene names	Adam12, Mltna
Domain Architecture
Description	ADAM 12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 12) (Meltrin alpha).

NID1_MOUSE
NC score	0.004400 (rank : 65)	θ value	1.06291 (rank : 49)
Query Neighborhood Hits	66	Target Neighborhood Hits	335	Shared Neighborhood Hits	5
SwissProt Accessions	P10493, Q8BQI3, Q8C3U8, Q8C9P6	Gene names	Nid1, Ent
Domain Architecture
Description	Nidogen-1 precursor (Entactin).

SNCAP_HUMAN
NC score	0.003952 (rank : 66)	θ value	5.27518 (rank : 60)
Query Neighborhood Hits	66	Target Neighborhood Hits	313	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6H5	Gene names	SNCAIP
Domain Architecture
Description	Synphilin-1 (Alpha-synuclein-interacting protein).

SMAL1_MOUSE
NC score	0.003004 (rank : 67)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	66	Target Neighborhood Hits	157	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BJL0, Q8BVK7, Q8BXW4, Q8K309, Q9EQK8, Q9QYC4	Gene names	Smarcal1, Harp
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 1) (HepA-related protein) (mharp).

MAGD4_HUMAN
NC score	0.000518 (rank : 68)	θ value	8.99809 (rank : 65)
Query Neighborhood Hits	66	Target Neighborhood Hits	338	Shared Neighborhood Hits	3
SwissProt Accessions	Q96JG8, Q8WXW4, Q9BQ84, Q9BYH3, Q9BYH4	Gene names	MAGED4, KIAA1859, MAGEE1
Domain Architecture
Description	Melanoma-associated antigen D4 (MAGE-D4 antigen) (MAGE-E1 antigen).