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Network neighborhood for query Sequence : VTNC_MOUSE

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VTNC_MOUSE
SwissProt Accessions	P29788, Q8VII4	Gene names	Vtn
Domain Architecture
Description	Vitronectin precursor (Serum-spreading factor) (S-protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

VTNC_HUMAN
θ value	0 (rank : 1)	NC score	0.988445 (rank : 2)
Query Neighborhood Hits	74	Target Neighborhood Hits	66	Shared Neighborhood Hits	50
SwissProt Accessions	P04004, P01141, Q9BSH7	Gene names	VTN
Domain Architecture
Description	Vitronectin precursor (Serum-spreading factor) (S-protein) (V75) [Contains: Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin B].

VTNC_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	74
SwissProt Accessions	P29788, Q8VII4	Gene names	Vtn
Domain Architecture
Description	Vitronectin precursor (Serum-spreading factor) (S-protein).

PRG4_MOUSE
θ value	1.37539e-32 (rank : 3)	NC score	0.535801 (rank : 45)
Query Neighborhood Hits	74	Target Neighborhood Hits	624	Shared Neighborhood Hits	55
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PRG4_HUMAN
θ value	8.91499e-32 (rank : 4)	NC score	0.472680 (rank : 46)
Query Neighborhood Hits	74	Target Neighborhood Hits	764	Shared Neighborhood Hits	54
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

MMP24_HUMAN
θ value	2.7842e-17 (rank : 5)	NC score	0.746378 (rank : 5)
Query Neighborhood Hits	74	Target Neighborhood Hits	66	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y5R2, Q9H440	Gene names	MMP24, MT5MMP
Domain Architecture
Description	Matrix metalloproteinase-24 precursor (EC 3.4.24.-) (MMP-24) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP).

MMP24_MOUSE
θ value	1.058e-16 (rank : 6)	NC score	0.746259 (rank : 6)
Query Neighborhood Hits	74	Target Neighborhood Hits	71	Shared Neighborhood Hits	43
SwissProt Accessions	Q9R0S2, Q9Z0J9	Gene names	Mmp24, Mmp21, Mt5mmp
Domain Architecture
Description	Matrix metalloproteinase-24 precursor (EC 3.4.24.-) (MMP-24) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP) (MMP-21).

MMP16_HUMAN
θ value	1.38178e-16 (rank : 7)	NC score	0.748361 (rank : 3)
Query Neighborhood Hits	74	Target Neighborhood Hits	68	Shared Neighborhood Hits	43
SwissProt Accessions	P51512, Q14824, Q52H48	Gene names	MMP16, MMPX2
Domain Architecture
Description	Matrix metalloproteinase-16 precursor (EC 3.4.24.-) (MMP-16) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP) (MMP- X2).

MMP16_MOUSE
θ value	4.02038e-16 (rank : 8)	NC score	0.747995 (rank : 4)
Query Neighborhood Hits	74	Target Neighborhood Hits	72	Shared Neighborhood Hits	43
SwissProt Accessions	Q9WTR0, Q9ERT6	Gene names	Mmp16
Domain Architecture
Description	Matrix metalloproteinase-16 precursor (EC 3.4.24.-) (MMP-16) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP).

MMP15_HUMAN
θ value	5.25075e-16 (rank : 9)	NC score	0.743279 (rank : 9)
Query Neighborhood Hits	74	Target Neighborhood Hits	95	Shared Neighborhood Hits	43
SwissProt Accessions	P51511, Q14111	Gene names	MMP15
Domain Architecture
Description	Matrix metalloproteinase-15 precursor (EC 3.4.24.-) (MMP-15) (Membrane-type matrix metalloproteinase 2) (MT-MMP 2) (MTMMP2) (Membrane-type-2 matrix metalloproteinase) (MT2-MMP) (MT2MMP) (SMCP- 2).

MMP15_MOUSE
θ value	4.44505e-15 (rank : 10)	NC score	0.741363 (rank : 10)
Query Neighborhood Hits	74	Target Neighborhood Hits	102	Shared Neighborhood Hits	43
SwissProt Accessions	O54732	Gene names	Mmp15
Domain Architecture
Description	Matrix metalloproteinase-15 precursor (EC 3.4.24.-) (MMP-15) (Membrane-type matrix metalloproteinase 2) (MT-MMP 2) (MTMMP2) (Membrane-type-2 matrix metalloproteinase) (MT2-MMP) (MT2MMP).

MMP14_MOUSE
θ value	2.20605e-14 (rank : 11)	NC score	0.745857 (rank : 7)
Query Neighborhood Hits	74	Target Neighborhood Hits	57	Shared Neighborhood Hits	43
SwissProt Accessions	P53690, O08645, O35369	Gene names	Mmp14, Mtmmp
Domain Architecture
Description	Matrix metalloproteinase-14 precursor (EC 3.4.24.80) (MMP-14) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP) (MMP-X1) (MT-MMP).

MMP14_HUMAN
θ value	2.88119e-14 (rank : 12)	NC score	0.745811 (rank : 8)
Query Neighborhood Hits	74	Target Neighborhood Hits	60	Shared Neighborhood Hits	43
SwissProt Accessions	P50281, Q92678	Gene names	MMP14
Domain Architecture
Description	Matrix metalloproteinase-14 precursor (EC 3.4.24.80) (MMP-14) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP) (MMP- X1).

MMP17_HUMAN
θ value	1.42992e-13 (rank : 13)	NC score	0.739673 (rank : 11)
Query Neighborhood Hits	74	Target Neighborhood Hits	56	Shared Neighborhood Hits	43
SwissProt Accessions	Q9ULZ9, Q14850	Gene names	MMP17, MT4MMP
Domain Architecture
Description	Matrix metalloproteinase-17 precursor (EC 3.4.24.-) (MMP-17) (Membrane-type matrix metalloproteinase 4) (MT-MMP 4) (Membrane-type-4 matrix metalloproteinase) (MT4-MMP).

MMP11_MOUSE
θ value	3.18553e-13 (rank : 14)	NC score	0.733988 (rank : 14)
Query Neighborhood Hits	74	Target Neighborhood Hits	53	Shared Neighborhood Hits	43
SwissProt Accessions	Q02853	Gene names	Mmp11
Domain Architecture
Description	Stromelysin-3 precursor (EC 3.4.24.-) (ST3) (SL-3) (Matrix metalloproteinase-11) (MMP-11).

MMP17_MOUSE
θ value	4.16044e-13 (rank : 15)	NC score	0.737794 (rank : 13)
Query Neighborhood Hits	74	Target Neighborhood Hits	60	Shared Neighborhood Hits	43
SwissProt Accessions	Q9R0S3	Gene names	Mmp17, Mt4mmp
Domain Architecture
Description	Matrix metalloproteinase-17 precursor (EC 3.4.24.-) (MMP-17) (Membrane-type matrix metalloproteinase 4) (MT-MMP 4) (Membrane-type-4 matrix metalloproteinase) (MT4-MMP).

MMP19_MOUSE
θ value	1.02475e-11 (rank : 16)	NC score	0.738177 (rank : 12)
Query Neighborhood Hits	74	Target Neighborhood Hits	56	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JHI0, Q8C360	Gene names	Mmp19, Rasi
Domain Architecture
Description	Matrix metalloproteinase-19 precursor (EC 3.4.24.-) (MMP-19) (Matrix metalloproteinase RASI).

MMP13_HUMAN
θ value	2.98157e-11 (rank : 17)	NC score	0.709050 (rank : 22)
Query Neighborhood Hits	74	Target Neighborhood Hits	60	Shared Neighborhood Hits	43
SwissProt Accessions	P45452	Gene names	MMP13
Domain Architecture
Description	Collagenase 3 precursor (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13).

MMP19_HUMAN
θ value	2.98157e-11 (rank : 18)	NC score	0.732215 (rank : 16)
Query Neighborhood Hits	74	Target Neighborhood Hits	51	Shared Neighborhood Hits	43
SwissProt Accessions	Q99542, O15278, O95606, Q99580	Gene names	MMP19, MMP18, RASI
Domain Architecture
Description	Matrix metalloproteinase-19 precursor (EC 3.4.24.-) (MMP-19) (Matrix metalloproteinase RASI) (MMP-18).

MMP8_MOUSE
θ value	6.64225e-11 (rank : 19)	NC score	0.711739 (rank : 19)
Query Neighborhood Hits	74	Target Neighborhood Hits	57	Shared Neighborhood Hits	43
SwissProt Accessions	O70138, O88733	Gene names	Mmp8
Domain Architecture
Description	Neutrophil collagenase precursor (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (Collagenase 2).

MMP11_HUMAN
θ value	1.133e-10 (rank : 20)	NC score	0.732637 (rank : 15)
Query Neighborhood Hits	74	Target Neighborhood Hits	65	Shared Neighborhood Hits	43
SwissProt Accessions	P24347, Q5FX24, Q6PEZ6, Q9UC26	Gene names	MMP11, STMY3
Domain Architecture
Description	Stromelysin-3 precursor (EC 3.4.24.-) (ST3) (SL-3) (Matrix metalloproteinase-11) (MMP-11).

MMP12_HUMAN
θ value	1.47974e-10 (rank : 21)	NC score	0.712583 (rank : 18)
Query Neighborhood Hits	74	Target Neighborhood Hits	57	Shared Neighborhood Hits	43
SwissProt Accessions	P39900	Gene names	MMP12, HME
Domain Architecture
Description	Macrophage metalloelastase precursor (EC 3.4.24.65) (HME) (Matrix metalloproteinase-12) (MMP-12) (Macrophage elastase) (ME).

MMP8_HUMAN
θ value	1.47974e-10 (rank : 22)	NC score	0.709711 (rank : 21)
Query Neighborhood Hits	74	Target Neighborhood Hits	54	Shared Neighborhood Hits	43
SwissProt Accessions	P22894, Q45F99	Gene names	MMP8, CLG1
Domain Architecture
Description	Neutrophil collagenase precursor (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (PMNL collagenase) (PMNL-CL).

MMP25_HUMAN
θ value	3.29651e-10 (rank : 23)	NC score	0.728896 (rank : 17)
Query Neighborhood Hits	74	Target Neighborhood Hits	56	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NPA2, Q9H3Q0	Gene names	MMP25, MT6MMP
Domain Architecture
Description	Matrix metalloproteinase-25 precursor (EC 3.4.24.-) (MMP-25) (Membrane-type matrix metalloproteinase 6) (MT-MMP 6) (Membrane-type-6 matrix metalloproteinase) (MT6-MMP) (Leukolysin).

MMP12_MOUSE
θ value	1.25267e-09 (rank : 24)	NC score	0.707971 (rank : 23)
Query Neighborhood Hits	74	Target Neighborhood Hits	56	Shared Neighborhood Hits	43
SwissProt Accessions	P34960, Q8BJ92, Q8BJB3, Q8BJB6, Q8BJB8, Q8BJB9, Q8VED6	Gene names	Mmp12, Mme, Mmel
Domain Architecture
Description	Macrophage metalloelastase precursor (EC 3.4.24.65) (MME) (Matrix metalloproteinase-12) (MMP-12).

HEMO_HUMAN
θ value	1.63604e-09 (rank : 25)	NC score	0.677717 (rank : 36)
Query Neighborhood Hits	74	Target Neighborhood Hits	47	Shared Neighborhood Hits	43
SwissProt Accessions	P02790	Gene names	HPX
Domain Architecture
Description	Hemopexin precursor (Beta-1B-glycoprotein).

MMP2_MOUSE
θ value	1.63604e-09 (rank : 26)	NC score	0.661829 (rank : 37)
Query Neighborhood Hits	74	Target Neighborhood Hits	77	Shared Neighborhood Hits	43
SwissProt Accessions	P33434	Gene names	Mmp2
Domain Architecture
Description	72 kDa type IV collagenase precursor (EC 3.4.24.24) (72 kDa gelatinase) (Matrix metalloproteinase-2) (MMP-2) (Gelatinase A).

MMP2_HUMAN
θ value	2.13673e-09 (rank : 27)	NC score	0.660515 (rank : 38)
Query Neighborhood Hits	74	Target Neighborhood Hits	79	Shared Neighborhood Hits	43
SwissProt Accessions	P08253	Gene names	MMP2, CLG4A
Domain Architecture
Description	72 kDa type IV collagenase precursor (EC 3.4.24.24) (72 kDa gelatinase) (Matrix metalloproteinase-2) (MMP-2) (Gelatinase A) (TBE- 1).

MMP1_HUMAN
θ value	2.79066e-09 (rank : 28)	NC score	0.689871 (rank : 33)
Query Neighborhood Hits	74	Target Neighborhood Hits	55	Shared Neighborhood Hits	43
SwissProt Accessions	P03956, P08156	Gene names	MMP1, CLG
Domain Architecture
Description	Interstitial collagenase precursor (EC 3.4.24.7) (Matrix metalloproteinase-1) (MMP-1) (Fibroblast collagenase) [Contains: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase].

MMP10_MOUSE
θ value	8.11959e-09 (rank : 29)	NC score	0.706111 (rank : 24)
Query Neighborhood Hits	74	Target Neighborhood Hits	57	Shared Neighborhood Hits	43
SwissProt Accessions	O55123	Gene names	Mmp10
Domain Architecture
Description	Stromelysin-2 precursor (EC 3.4.24.22) (Matrix metalloproteinase-10) (MMP-10) (Transin-2) (SL-2).

MMP1A_MOUSE
θ value	8.11959e-09 (rank : 30)	NC score	0.699528 (rank : 27)
Query Neighborhood Hits	74	Target Neighborhood Hits	58	Shared Neighborhood Hits	43
SwissProt Accessions	Q9EPL5	Gene names	Mmp1a, McolA
Domain Architecture	No domain graphic available
Description	Interstitial collagenase A precursor (EC 3.4.24.7) (Matrix metalloproteinase-1a) (MMP-1a) (Mcol-A).

MMP3_MOUSE
θ value	3.08544e-08 (rank : 31)	NC score	0.697461 (rank : 29)
Query Neighborhood Hits	74	Target Neighborhood Hits	53	Shared Neighborhood Hits	43
SwissProt Accessions	P28862	Gene names	Mmp3
Domain Architecture
Description	Stromelysin-1 precursor (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1) (SL-1) (EMS-2).

MMP3_HUMAN
θ value	4.0297e-08 (rank : 32)	NC score	0.699660 (rank : 26)
Query Neighborhood Hits	74	Target Neighborhood Hits	50	Shared Neighborhood Hits	43
SwissProt Accessions	P08254, Q3B7S0	Gene names	MMP3, STMY1
Domain Architecture
Description	Stromelysin-1 precursor (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1) (SL-1).

MMP1B_MOUSE
θ value	5.26297e-08 (rank : 33)	NC score	0.696686 (rank : 30)
Query Neighborhood Hits	74	Target Neighborhood Hits	64	Shared Neighborhood Hits	43
SwissProt Accessions	Q9EPL6	Gene names	Mmp1b, McolB
Domain Architecture	No domain graphic available
Description	Interstitial collagenase B precursor (EC 3.4.24.7) (Matrix metalloproteinase-1b) (MMP-1b) (Mcol-B).

MMP10_HUMAN
θ value	6.87365e-08 (rank : 34)	NC score	0.701104 (rank : 25)
Query Neighborhood Hits	74	Target Neighborhood Hits	50	Shared Neighborhood Hits	43
SwissProt Accessions	P09238	Gene names	MMP10, STMY2
Domain Architecture
Description	Stromelysin-2 precursor (EC 3.4.24.22) (Matrix metalloproteinase-10) (MMP-10) (Transin-2) (SL-2).

MMP13_MOUSE
θ value	1.99992e-07 (rank : 35)	NC score	0.694723 (rank : 31)
Query Neighborhood Hits	74	Target Neighborhood Hits	56	Shared Neighborhood Hits	43
SwissProt Accessions	P33435	Gene names	Mmp13
Domain Architecture
Description	Collagenase 3 precursor (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13).

MMP21_MOUSE
θ value	5.81887e-07 (rank : 36)	NC score	0.699118 (rank : 28)
Query Neighborhood Hits	74	Target Neighborhood Hits	59	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K3F2	Gene names	Mmp21
Domain Architecture	No domain graphic available
Description	Matrix metalloproteinase-21 precursor (EC 3.4.24.-) (MMP-21).

HEMO_MOUSE
θ value	9.92553e-07 (rank : 37)	NC score	0.599346 (rank : 43)
Query Neighborhood Hits	74	Target Neighborhood Hits	48	Shared Neighborhood Hits	43
SwissProt Accessions	Q91X72, P97824, Q8WUP0	Gene names	Hpx, Hpxn
Domain Architecture
Description	Hemopexin precursor.

MMP28_HUMAN
θ value	9.92553e-07 (rank : 38)	NC score	0.711425 (rank : 20)
Query Neighborhood Hits	74	Target Neighborhood Hits	55	Shared Neighborhood Hits	43
SwissProt Accessions	Q9H239, Q96TE2	Gene names	MMP28, MMP25
Domain Architecture
Description	Matrix metalloproteinase-28 precursor (EC 3.4.24.-) (MMP-28) (Epilysin).

MMP9_HUMAN
θ value	1.29631e-06 (rank : 39)	NC score	0.613358 (rank : 42)
Query Neighborhood Hits	74	Target Neighborhood Hits	125	Shared Neighborhood Hits	42
SwissProt Accessions	P14780, Q3LR70, Q8N725, Q9H4Z1	Gene names	MMP9, CLG4B
Domain Architecture
Description	Matrix metalloproteinase-9 precursor (EC 3.4.24.35) (MMP-9) (92 kDa type IV collagenase) (92 kDa gelatinase) (Gelatinase B) (GELB) [Contains: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9].

MMP21_HUMAN
θ value	4.92598e-06 (rank : 40)	NC score	0.690146 (rank : 32)
Query Neighborhood Hits	74	Target Neighborhood Hits	76	Shared Neighborhood Hits	44
SwissProt Accessions	Q8N119, Q8NG02	Gene names	MMP21
Domain Architecture	No domain graphic available
Description	Matrix metalloproteinase-21 precursor (EC 3.4.24.-) (MMP-21).

MMP20_MOUSE
θ value	3.19293e-05 (rank : 41)	NC score	0.683440 (rank : 35)
Query Neighborhood Hits	74	Target Neighborhood Hits	56	Shared Neighborhood Hits	43
SwissProt Accessions	P57748	Gene names	Mmp20
Domain Architecture
Description	Matrix metalloproteinase-20 precursor (EC 3.4.24.-) (MMP-20) (Enamel metalloproteinase) (Enamelysin).

MMP20_HUMAN
θ value	4.1701e-05 (rank : 42)	NC score	0.684767 (rank : 34)
Query Neighborhood Hits	74	Target Neighborhood Hits	56	Shared Neighborhood Hits	43
SwissProt Accessions	O60882, Q6DKT9	Gene names	MMP20
Domain Architecture
Description	Matrix metalloproteinase-20 precursor (EC 3.4.24.-) (MMP-20) (Enamel metalloproteinase) (Enamelysin).

ENPP2_HUMAN
θ value	0.000602161 (rank : 43)	NC score	0.166359 (rank : 48)
Query Neighborhood Hits	74	Target Neighborhood Hits	61	Shared Neighborhood Hits	11
SwissProt Accessions	Q13822, Q13827, Q15117	Gene names	ENPP2, ATX, PDNP2
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2) (Phosphodiesterase I/nucleotide pyrophosphatase 2) (Phosphodiesterase I alpha) (PD-Ialpha) (Autotaxin) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP2_MOUSE
θ value	0.00102713 (rank : 44)	NC score	0.165536 (rank : 49)
Query Neighborhood Hits	74	Target Neighborhood Hits	66	Shared Neighborhood Hits	11
SwissProt Accessions	Q9R1E6, Q99LG9	Gene names	Enpp2, Npps2
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2) (Phosphodiesterase I/nucleotide pyrophosphatase 2) (Phosphodiesterase I alpha) (PD-Ialpha) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP1_HUMAN
θ value	0.00390308 (rank : 45)	NC score	0.154892 (rank : 50)
Query Neighborhood Hits	74	Target Neighborhood Hits	47	Shared Neighborhood Hits	12
SwissProt Accessions	P22413, Q5T9R6, Q9NPZ3, Q9P1P6, Q9UP61, Q9Y6K3	Gene names	ENPP1, NPPS, PC1, PDNP1
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

MMP9_MOUSE
θ value	0.00509761 (rank : 46)	NC score	0.588614 (rank : 44)
Query Neighborhood Hits	74	Target Neighborhood Hits	151	Shared Neighborhood Hits	43
SwissProt Accessions	P41245, Q06788, Q9DC02	Gene names	Mmp9, Clg4b
Domain Architecture
Description	Matrix metalloproteinase-9 precursor (EC 3.4.24.35) (MMP-9) (92 kDa type IV collagenase) (92 kDa gelatinase) (Gelatinase B) (GELB).

ENPP1_MOUSE
θ value	0.00869519 (rank : 47)	NC score	0.154871 (rank : 51)
Query Neighborhood Hits	74	Target Neighborhood Hits	65	Shared Neighborhood Hits	11
SwissProt Accessions	P06802	Gene names	Enpp1, Npps, Pc1, Pdnp1
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) (Antigen Ly-41) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

PP11_HUMAN
θ value	0.0113563 (rank : 48)	NC score	0.253478 (rank : 47)
Query Neighborhood Hits	74	Target Neighborhood Hits	20	Shared Neighborhood Hits	11
SwissProt Accessions	P21128, Q2NKJ4	Gene names
Domain Architecture
Description	Placental protein 11 precursor (EC 3.4.21.-) (PP11).

SYNJ2_MOUSE
θ value	0.0431538 (rank : 49)	NC score	0.030392 (rank : 73)
Query Neighborhood Hits	74	Target Neighborhood Hits	87	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D2G5, O35404, O88399, O88400, O88401, O88402, O88403, O88404	Gene names	Synj2, Kiaa0348
Domain Architecture
Description	Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 2).

BCL7B_MOUSE
θ value	0.0961366 (rank : 50)	NC score	0.057028 (rank : 63)
Query Neighborhood Hits	74	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q921K9, O89022, Q3TV31, Q3U2W0	Gene names	Bcl7b
Domain Architecture	No domain graphic available
Description	B-cell CLL/lymphoma 7 protein family member B.

BCL7B_HUMAN
θ value	0.279714 (rank : 51)	NC score	0.052385 (rank : 67)
Query Neighborhood Hits	74	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BQE9, O43769, Q13845, Q6ZW75	Gene names	BCL7B
Domain Architecture	No domain graphic available
Description	B-cell CLL/lymphoma 7 protein family member B.

ENPP3_HUMAN
θ value	0.47712 (rank : 52)	NC score	0.134652 (rank : 52)
Query Neighborhood Hits	74	Target Neighborhood Hits	34	Shared Neighborhood Hits	11
SwissProt Accessions	O14638	Gene names	ENPP3, PDNP3
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 3 (E-NPP 3) (Phosphodiesterase I/nucleotide pyrophosphatase 3) (Phosphodiesterase I beta) (PD-Ibeta) (CD203c antigen) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

K1802_MOUSE
θ value	0.47712 (rank : 53)	NC score	0.038429 (rank : 72)
Query Neighborhood Hits	74	Target Neighborhood Hits	1596	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

LAMA1_HUMAN
θ value	1.06291 (rank : 54)	NC score	0.004688 (rank : 86)
Query Neighborhood Hits	74	Target Neighborhood Hits	804	Shared Neighborhood Hits	4
SwissProt Accessions	P25391	Gene names	LAMA1, LAMA
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

T22D2_HUMAN
θ value	1.06291 (rank : 55)	NC score	0.024096 (rank : 74)
Query Neighborhood Hits	74	Target Neighborhood Hits	250	Shared Neighborhood Hits	5
SwissProt Accessions	O75157, Q6PI50, Q9H2Z6, Q9H2Z7, Q9H2Z8	Gene names	TSC22D2, KIAA0669, TILZ4
Domain Architecture	No domain graphic available
Description	TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4).

G3BP2_MOUSE
θ value	1.81305 (rank : 56)	NC score	0.019218 (rank : 76)
Query Neighborhood Hits	74	Target Neighborhood Hits	258	Shared Neighborhood Hits	5
SwissProt Accessions	P97379, Q9R1B8	Gene names	G3bp2
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 2 (GAP SH3-domain- binding protein 2) (G3BP-2).

FAK2_HUMAN
θ value	2.36792 (rank : 57)	NC score	-0.001457 (rank : 92)
Query Neighborhood Hits	74	Target Neighborhood Hits	847	Shared Neighborhood Hits	4
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

NEK11_HUMAN
θ value	2.36792 (rank : 58)	NC score	-0.002715 (rank : 93)
Query Neighborhood Hits	74	Target Neighborhood Hits	1043	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).

IASPP_MOUSE
θ value	3.0926 (rank : 59)	NC score	0.005067 (rank : 85)
Query Neighborhood Hits	74	Target Neighborhood Hits	1024	Shared Neighborhood Hits	7
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

TR10C_HUMAN
θ value	4.03905 (rank : 60)	NC score	0.012351 (rank : 81)
Query Neighborhood Hits	74	Target Neighborhood Hits	105	Shared Neighborhood Hits	3
SwissProt Accessions	O14798, O14755, Q6UXM5	Gene names	TNFRSF10C, DCR1, LIT, TRAILR3, TRID
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 10C precursor (Decoy receptor 1) (DcR1) (Decoy TRAIL receptor without death domain) (TNF- related apoptosis-inducing ligand receptor 3) (TRAIL receptor 3) (TRAIL-R3) (Trail receptor without an intracellular domain) (Lymphocyte inhibitor of TRAIL) (Antagonist decoy receptor for TRAIL/Apo-2L) (CD263 antigen).

AQR_HUMAN
θ value	5.27518 (rank : 61)	NC score	0.019972 (rank : 75)
Query Neighborhood Hits	74	Target Neighborhood Hits	88	Shared Neighborhood Hits	4
SwissProt Accessions	O60306, Q2YDX9, Q6IRU8, Q6PIC8	Gene names	AQR, KIAA0560
Domain Architecture	No domain graphic available
Description	Intron-binding protein aquarius (Intron-binding protein of 160 kDa) (IBP160).

CEND3_HUMAN
θ value	5.27518 (rank : 62)	NC score	0.005099 (rank : 84)
Query Neighborhood Hits	74	Target Neighborhood Hits	275	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

FOXC1_HUMAN
θ value	5.27518 (rank : 63)	NC score	0.003380 (rank : 88)
Query Neighborhood Hits	74	Target Neighborhood Hits	208	Shared Neighborhood Hits	5
SwissProt Accessions	Q12948, Q86UP7, Q9BYM1, Q9NUE5, Q9UDD0, Q9UP06	Gene names	FOXC1, FKHL7, FREAC3
Domain Architecture
Description	Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead- related transcription factor 3) (FREAC-3).

G3BP2_HUMAN
θ value	5.27518 (rank : 64)	NC score	0.015808 (rank : 78)
Query Neighborhood Hits	74	Target Neighborhood Hits	260	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UN86, O60606, O75149, Q9UPA1	Gene names	G3BP2, KIAA0660
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 2 (GAP SH3-domain- binding protein 2) (G3BP-2).

ATBF1_HUMAN
θ value	6.88961 (rank : 65)	NC score	-0.001082 (rank : 91)
Query Neighborhood Hits	74	Target Neighborhood Hits	1547	Shared Neighborhood Hits	8
SwissProt Accessions	Q15911, O15101, Q13719	Gene names	ATBF1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

HA11_MOUSE
θ value	6.88961 (rank : 66)	NC score	-0.000278 (rank : 90)
Query Neighborhood Hits	74	Target Neighborhood Hits	217	Shared Neighborhood Hits	3
SwissProt Accessions	P01899	Gene names	H2-D1
Domain Architecture
Description	H-2 class I histocompatibility antigen, D-B alpha chain precursor (H- 2D(B)).

MADCA_HUMAN
θ value	6.88961 (rank : 67)	NC score	0.013609 (rank : 80)
Query Neighborhood Hits	74	Target Neighborhood Hits	221	Shared Neighborhood Hits	6
SwissProt Accessions	Q13477, O60222, O75867	Gene names	MADCAM1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (hMAdCAM-1).

MAP1B_HUMAN
θ value	6.88961 (rank : 68)	NC score	0.010407 (rank : 82)
Query Neighborhood Hits	74	Target Neighborhood Hits	903	Shared Neighborhood Hits	10
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

OCLN_HUMAN
θ value	6.88961 (rank : 69)	NC score	0.010342 (rank : 83)
Query Neighborhood Hits	74	Target Neighborhood Hits	131	Shared Neighborhood Hits	2
SwissProt Accessions	Q16625, Q8N6K1	Gene names	OCLN
Domain Architecture
Description	Occludin.

SUSD2_HUMAN
θ value	6.88961 (rank : 70)	NC score	0.041365 (rank : 71)
Query Neighborhood Hits	74	Target Neighborhood Hits	99	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UGT4, Q9H5Y6	Gene names	SUSD2
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 2 precursor.

AMPH_HUMAN
θ value	8.99809 (rank : 71)	NC score	0.017057 (rank : 77)
Query Neighborhood Hits	74	Target Neighborhood Hits	455	Shared Neighborhood Hits	8
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

ETV4_MOUSE
θ value	8.99809 (rank : 72)	NC score	0.003662 (rank : 87)
Query Neighborhood Hits	74	Target Neighborhood Hits	100	Shared Neighborhood Hits	3
SwissProt Accessions	P28322	Gene names	Etv4, Pea-3, Pea3
Domain Architecture
Description	ETS translocation variant 4 (Polyomavirus enhancer activator 3) (Protein PEA3).

IWS1_MOUSE
θ value	8.99809 (rank : 73)	NC score	0.014755 (rank : 79)
Query Neighborhood Hits	74	Target Neighborhood Hits	1258	Shared Neighborhood Hits	15
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

MYST3_MOUSE
θ value	8.99809 (rank : 74)	NC score	0.002591 (rank : 89)
Query Neighborhood Hits	74	Target Neighborhood Hits	688	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

ENPP5_HUMAN
θ value	θ > 10 (rank : 75)	NC score	0.061619 (rank : 59)
Query Neighborhood Hits	74	Target Neighborhood Hits	16	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UJA9, Q6UX49	Gene names	ENPP5
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 5 precursor (EC 3.1.-.-) (E-NPP5) (NPP-5).

ENPP5_MOUSE
θ value	θ > 10 (rank : 76)	NC score	0.061479 (rank : 60)
Query Neighborhood Hits	74	Target Neighborhood Hits	14	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EQG7, Q921P7	Gene names	Enpp5
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 5 precursor (EC 3.1.-.-) (E-NPP5) (NPP-5).

ENPP6_HUMAN
θ value	θ > 10 (rank : 77)	NC score	0.059948 (rank : 61)
Query Neighborhood Hits	74	Target Neighborhood Hits	17	Shared Neighborhood Hits	5
SwissProt Accessions	Q6UWR7, Q96M57	Gene names	ENPP6
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 6 precursor (EC 3.1.-.-) (E-NPP6) (NPP-6) [Contains: Ectonucleotide pyrophosphatase/phosphodiesterase 6 soluble form].

ENPP6_MOUSE
θ value	θ > 10 (rank : 78)	NC score	0.059657 (rank : 62)
Query Neighborhood Hits	74	Target Neighborhood Hits	16	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BGN3, Q4VAH5	Gene names	Enpp6
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 6 precursor (EC 3.1.-.-) (E-NPP6) (NPP-6) [Contains: Ectonucleotide pyrophosphatase/phosphodiesterase 6 soluble form].

ENPP7_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.063317 (rank : 58)
Query Neighborhood Hits	74	Target Neighborhood Hits	30	Shared Neighborhood Hits	5
SwissProt Accessions	Q6UWV6, Q6ZTS5, Q8IUS8	Gene names	ENPP7
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 7 precursor (EC 3.1.4.12) (E-NPP7) (NPP-7) (Alkaline sphingomyelin phosphodiesterase) (Intestinal alkaline sphingomyelinase) (Alk-SMase).

MDC1_HUMAN
θ value	θ > 10 (rank : 80)	NC score	0.056526 (rank : 64)
Query Neighborhood Hits	74	Target Neighborhood Hits	1446	Shared Neighborhood Hits	17
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MMP26_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.619467 (rank : 41)
Query Neighborhood Hits	74	Target Neighborhood Hits	56	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NRE1, Q9GZS2, Q9NR87	Gene names	MMP26
Domain Architecture
Description	Matrix metalloproteinase-26 precursor (EC 3.4.24.-) (MMP-26) (Matrilysin-2) (Endometase).

MMP7_HUMAN
θ value	θ > 10 (rank : 82)	NC score	0.621990 (rank : 39)
Query Neighborhood Hits	74	Target Neighborhood Hits	49	Shared Neighborhood Hits	37
SwissProt Accessions	P09237, Q9BTK9	Gene names	MMP7, MPSL1, PUMP1
Domain Architecture
Description	Matrilysin precursor (EC 3.4.24.23) (Pump-1 protease) (Uterine metalloproteinase) (Matrix metalloproteinase-7) (MMP-7) (Matrin).

MMP7_MOUSE
θ value	θ > 10 (rank : 83)	NC score	0.619702 (rank : 40)
Query Neighborhood Hits	74	Target Neighborhood Hits	60	Shared Neighborhood Hits	37
SwissProt Accessions	Q10738	Gene names	Mmp7
Domain Architecture
Description	Matrilysin precursor (EC 3.4.24.23) (Pump-1 protease) (Uterine metalloproteinase) (Matrix metalloproteinase-7) (MMP-7) (Matrin).

PRAX_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.071281 (rank : 57)
Query Neighborhood Hits	74	Target Neighborhood Hits	215	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BXM0, Q9BXL9, Q9HCF2	Gene names	PRX, KIAA1620
Domain Architecture
Description	Periaxin.

PRAX_MOUSE
θ value	θ > 10 (rank : 85)	NC score	0.056500 (rank : 65)
Query Neighborhood Hits	74	Target Neighborhood Hits	199	Shared Neighborhood Hits	5
SwissProt Accessions	O55103, O55104	Gene names	Prx
Domain Architecture
Description	Periaxin.

SEL1L_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.052909 (rank : 66)
Query Neighborhood Hits	74	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UBV2, Q6UWT6, Q9P1T9, Q9UHK7	Gene names	SEL1L, TSA305
Domain Architecture
Description	Sel-1 homolog precursor (Suppressor of lin-12-like protein) (Sel-1L).

SEL1L_MOUSE
θ value	θ > 10 (rank : 87)	NC score	0.051355 (rank : 69)
Query Neighborhood Hits	74	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z2G6, Q9DBD8	Gene names	Sel1l, Sel1h
Domain Architecture
Description	Sel-1 homolog precursor (Suppressor of lin-12-like protein) (Sel-1L).

SPR1A_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.051753 (rank : 68)
Query Neighborhood Hits	74	Target Neighborhood Hits	136	Shared Neighborhood Hits	6
SwissProt Accessions	P35321, Q9UDG4	Gene names	SPRR1A
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein IA) (SPR-IA) (SPRK) (19 kDa pancornulin).

SPR1A_MOUSE
θ value	θ > 10 (rank : 89)	NC score	0.074004 (rank : 56)
Query Neighborhood Hits	74	Target Neighborhood Hits	343	Shared Neighborhood Hits	10
SwissProt Accessions	Q62266	Gene names	Sprr1a
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein 1A) (SPR1A) (SPR1 A).

SPR1B_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.050975 (rank : 70)
Query Neighborhood Hits	74	Target Neighborhood Hits	102	Shared Neighborhood Hits	4
SwissProt Accessions	P22528, P22529, P22530, Q5T524	Gene names	SPRR1B
Domain Architecture	No domain graphic available
Description	Cornifin B (Small proline-rich protein IB) (SPR-IB) (14.9 kDa pancornulin).

SPR1B_MOUSE
θ value	θ > 10 (rank : 91)	NC score	0.079709 (rank : 55)
Query Neighborhood Hits	74	Target Neighborhood Hits	395	Shared Neighborhood Hits	10
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

SPRR3_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.096610 (rank : 53)
Query Neighborhood Hits	74	Target Neighborhood Hits	102	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UBC9, O75597, Q4ZGI7, Q5T525, Q8NET7, Q9UDG3	Gene names	SPRR3, SPRC
Domain Architecture
Description	Small proline-rich protein 3 (Cornifin beta) (Esophagin) (22 kDa pancornulin).

SPRR3_MOUSE
θ value	θ > 10 (rank : 93)	NC score	0.080258 (rank : 54)
Query Neighborhood Hits	74	Target Neighborhood Hits	106	Shared Neighborhood Hits	5
SwissProt Accessions	O09116	Gene names	Sprr3
Domain Architecture
Description	Small proline-rich protein 3 (Cornifin beta).

Hits sorted by NC score

VTNC_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	74
SwissProt Accessions	P29788, Q8VII4	Gene names	Vtn
Domain Architecture
Description	Vitronectin precursor (Serum-spreading factor) (S-protein).

VTNC_HUMAN
NC score	0.988445 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	74	Target Neighborhood Hits	66	Shared Neighborhood Hits	50
SwissProt Accessions	P04004, P01141, Q9BSH7	Gene names	VTN
Domain Architecture
Description	Vitronectin precursor (Serum-spreading factor) (S-protein) (V75) [Contains: Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin B].

MMP16_HUMAN
NC score	0.748361 (rank : 3)	θ value	1.38178e-16 (rank : 7)
Query Neighborhood Hits	74	Target Neighborhood Hits	68	Shared Neighborhood Hits	43
SwissProt Accessions	P51512, Q14824, Q52H48	Gene names	MMP16, MMPX2
Domain Architecture
Description	Matrix metalloproteinase-16 precursor (EC 3.4.24.-) (MMP-16) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP) (MMP- X2).

MMP16_MOUSE
NC score	0.747995 (rank : 4)	θ value	4.02038e-16 (rank : 8)
Query Neighborhood Hits	74	Target Neighborhood Hits	72	Shared Neighborhood Hits	43
SwissProt Accessions	Q9WTR0, Q9ERT6	Gene names	Mmp16
Domain Architecture
Description	Matrix metalloproteinase-16 precursor (EC 3.4.24.-) (MMP-16) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP).

MMP24_HUMAN
NC score	0.746378 (rank : 5)	θ value	2.7842e-17 (rank : 5)
Query Neighborhood Hits	74	Target Neighborhood Hits	66	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Y5R2, Q9H440	Gene names	MMP24, MT5MMP
Domain Architecture
Description	Matrix metalloproteinase-24 precursor (EC 3.4.24.-) (MMP-24) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP).

MMP24_MOUSE
NC score	0.746259 (rank : 6)	θ value	1.058e-16 (rank : 6)
Query Neighborhood Hits	74	Target Neighborhood Hits	71	Shared Neighborhood Hits	43
SwissProt Accessions	Q9R0S2, Q9Z0J9	Gene names	Mmp24, Mmp21, Mt5mmp
Domain Architecture
Description	Matrix metalloproteinase-24 precursor (EC 3.4.24.-) (MMP-24) (Membrane-type matrix metalloproteinase 5) (MT-MMP 5) (Membrane-type-5 matrix metalloproteinase) (MT5-MMP) (MMP-21).

MMP14_MOUSE
NC score	0.745857 (rank : 7)	θ value	2.20605e-14 (rank : 11)
Query Neighborhood Hits	74	Target Neighborhood Hits	57	Shared Neighborhood Hits	43
SwissProt Accessions	P53690, O08645, O35369	Gene names	Mmp14, Mtmmp
Domain Architecture
Description	Matrix metalloproteinase-14 precursor (EC 3.4.24.80) (MMP-14) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP) (MMP-X1) (MT-MMP).

MMP14_HUMAN
NC score	0.745811 (rank : 8)	θ value	2.88119e-14 (rank : 12)
Query Neighborhood Hits	74	Target Neighborhood Hits	60	Shared Neighborhood Hits	43
SwissProt Accessions	P50281, Q92678	Gene names	MMP14
Domain Architecture
Description	Matrix metalloproteinase-14 precursor (EC 3.4.24.80) (MMP-14) (Membrane-type matrix metalloproteinase 1) (MT-MMP 1) (MTMMP1) (Membrane-type-1 matrix metalloproteinase) (MT1-MMP) (MT1MMP) (MMP- X1).

MMP15_HUMAN
NC score	0.743279 (rank : 9)	θ value	5.25075e-16 (rank : 9)
Query Neighborhood Hits	74	Target Neighborhood Hits	95	Shared Neighborhood Hits	43
SwissProt Accessions	P51511, Q14111	Gene names	MMP15
Domain Architecture
Description	Matrix metalloproteinase-15 precursor (EC 3.4.24.-) (MMP-15) (Membrane-type matrix metalloproteinase 2) (MT-MMP 2) (MTMMP2) (Membrane-type-2 matrix metalloproteinase) (MT2-MMP) (MT2MMP) (SMCP- 2).

MMP15_MOUSE
NC score	0.741363 (rank : 10)	θ value	4.44505e-15 (rank : 10)
Query Neighborhood Hits	74	Target Neighborhood Hits	102	Shared Neighborhood Hits	43
SwissProt Accessions	O54732	Gene names	Mmp15
Domain Architecture
Description	Matrix metalloproteinase-15 precursor (EC 3.4.24.-) (MMP-15) (Membrane-type matrix metalloproteinase 2) (MT-MMP 2) (MTMMP2) (Membrane-type-2 matrix metalloproteinase) (MT2-MMP) (MT2MMP).

MMP17_HUMAN
NC score	0.739673 (rank : 11)	θ value	1.42992e-13 (rank : 13)
Query Neighborhood Hits	74	Target Neighborhood Hits	56	Shared Neighborhood Hits	43
SwissProt Accessions	Q9ULZ9, Q14850	Gene names	MMP17, MT4MMP
Domain Architecture
Description	Matrix metalloproteinase-17 precursor (EC 3.4.24.-) (MMP-17) (Membrane-type matrix metalloproteinase 4) (MT-MMP 4) (Membrane-type-4 matrix metalloproteinase) (MT4-MMP).

MMP19_MOUSE
NC score	0.738177 (rank : 12)	θ value	1.02475e-11 (rank : 16)
Query Neighborhood Hits	74	Target Neighborhood Hits	56	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JHI0, Q8C360	Gene names	Mmp19, Rasi
Domain Architecture
Description	Matrix metalloproteinase-19 precursor (EC 3.4.24.-) (MMP-19) (Matrix metalloproteinase RASI).

MMP17_MOUSE
NC score	0.737794 (rank : 13)	θ value	4.16044e-13 (rank : 15)
Query Neighborhood Hits	74	Target Neighborhood Hits	60	Shared Neighborhood Hits	43
SwissProt Accessions	Q9R0S3	Gene names	Mmp17, Mt4mmp
Domain Architecture
Description	Matrix metalloproteinase-17 precursor (EC 3.4.24.-) (MMP-17) (Membrane-type matrix metalloproteinase 4) (MT-MMP 4) (Membrane-type-4 matrix metalloproteinase) (MT4-MMP).

MMP11_MOUSE
NC score	0.733988 (rank : 14)	θ value	3.18553e-13 (rank : 14)
Query Neighborhood Hits	74	Target Neighborhood Hits	53	Shared Neighborhood Hits	43
SwissProt Accessions	Q02853	Gene names	Mmp11
Domain Architecture
Description	Stromelysin-3 precursor (EC 3.4.24.-) (ST3) (SL-3) (Matrix metalloproteinase-11) (MMP-11).

MMP11_HUMAN
NC score	0.732637 (rank : 15)	θ value	1.133e-10 (rank : 20)
Query Neighborhood Hits	74	Target Neighborhood Hits	65	Shared Neighborhood Hits	43
SwissProt Accessions	P24347, Q5FX24, Q6PEZ6, Q9UC26	Gene names	MMP11, STMY3
Domain Architecture
Description	Stromelysin-3 precursor (EC 3.4.24.-) (ST3) (SL-3) (Matrix metalloproteinase-11) (MMP-11).

MMP19_HUMAN
NC score	0.732215 (rank : 16)	θ value	2.98157e-11 (rank : 18)
Query Neighborhood Hits	74	Target Neighborhood Hits	51	Shared Neighborhood Hits	43
SwissProt Accessions	Q99542, O15278, O95606, Q99580	Gene names	MMP19, MMP18, RASI
Domain Architecture
Description	Matrix metalloproteinase-19 precursor (EC 3.4.24.-) (MMP-19) (Matrix metalloproteinase RASI) (MMP-18).

MMP25_HUMAN
NC score	0.728896 (rank : 17)	θ value	3.29651e-10 (rank : 23)
Query Neighborhood Hits	74	Target Neighborhood Hits	56	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NPA2, Q9H3Q0	Gene names	MMP25, MT6MMP
Domain Architecture
Description	Matrix metalloproteinase-25 precursor (EC 3.4.24.-) (MMP-25) (Membrane-type matrix metalloproteinase 6) (MT-MMP 6) (Membrane-type-6 matrix metalloproteinase) (MT6-MMP) (Leukolysin).

MMP12_HUMAN
NC score	0.712583 (rank : 18)	θ value	1.47974e-10 (rank : 21)
Query Neighborhood Hits	74	Target Neighborhood Hits	57	Shared Neighborhood Hits	43
SwissProt Accessions	P39900	Gene names	MMP12, HME
Domain Architecture
Description	Macrophage metalloelastase precursor (EC 3.4.24.65) (HME) (Matrix metalloproteinase-12) (MMP-12) (Macrophage elastase) (ME).

MMP8_MOUSE
NC score	0.711739 (rank : 19)	θ value	6.64225e-11 (rank : 19)
Query Neighborhood Hits	74	Target Neighborhood Hits	57	Shared Neighborhood Hits	43
SwissProt Accessions	O70138, O88733	Gene names	Mmp8
Domain Architecture
Description	Neutrophil collagenase precursor (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (Collagenase 2).

MMP28_HUMAN
NC score	0.711425 (rank : 20)	θ value	9.92553e-07 (rank : 38)
Query Neighborhood Hits	74	Target Neighborhood Hits	55	Shared Neighborhood Hits	43
SwissProt Accessions	Q9H239, Q96TE2	Gene names	MMP28, MMP25
Domain Architecture
Description	Matrix metalloproteinase-28 precursor (EC 3.4.24.-) (MMP-28) (Epilysin).

MMP8_HUMAN
NC score	0.709711 (rank : 21)	θ value	1.47974e-10 (rank : 22)
Query Neighborhood Hits	74	Target Neighborhood Hits	54	Shared Neighborhood Hits	43
SwissProt Accessions	P22894, Q45F99	Gene names	MMP8, CLG1
Domain Architecture
Description	Neutrophil collagenase precursor (EC 3.4.24.34) (Matrix metalloproteinase-8) (MMP-8) (PMNL collagenase) (PMNL-CL).

MMP13_HUMAN
NC score	0.709050 (rank : 22)	θ value	2.98157e-11 (rank : 17)
Query Neighborhood Hits	74	Target Neighborhood Hits	60	Shared Neighborhood Hits	43
SwissProt Accessions	P45452	Gene names	MMP13
Domain Architecture
Description	Collagenase 3 precursor (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13).

MMP12_MOUSE
NC score	0.707971 (rank : 23)	θ value	1.25267e-09 (rank : 24)
Query Neighborhood Hits	74	Target Neighborhood Hits	56	Shared Neighborhood Hits	43
SwissProt Accessions	P34960, Q8BJ92, Q8BJB3, Q8BJB6, Q8BJB8, Q8BJB9, Q8VED6	Gene names	Mmp12, Mme, Mmel
Domain Architecture
Description	Macrophage metalloelastase precursor (EC 3.4.24.65) (MME) (Matrix metalloproteinase-12) (MMP-12).

MMP10_MOUSE
NC score	0.706111 (rank : 24)	θ value	8.11959e-09 (rank : 29)
Query Neighborhood Hits	74	Target Neighborhood Hits	57	Shared Neighborhood Hits	43
SwissProt Accessions	O55123	Gene names	Mmp10
Domain Architecture
Description	Stromelysin-2 precursor (EC 3.4.24.22) (Matrix metalloproteinase-10) (MMP-10) (Transin-2) (SL-2).

MMP10_HUMAN
NC score	0.701104 (rank : 25)	θ value	6.87365e-08 (rank : 34)
Query Neighborhood Hits	74	Target Neighborhood Hits	50	Shared Neighborhood Hits	43
SwissProt Accessions	P09238	Gene names	MMP10, STMY2
Domain Architecture
Description	Stromelysin-2 precursor (EC 3.4.24.22) (Matrix metalloproteinase-10) (MMP-10) (Transin-2) (SL-2).

MMP3_HUMAN
NC score	0.699660 (rank : 26)	θ value	4.0297e-08 (rank : 32)
Query Neighborhood Hits	74	Target Neighborhood Hits	50	Shared Neighborhood Hits	43
SwissProt Accessions	P08254, Q3B7S0	Gene names	MMP3, STMY1
Domain Architecture
Description	Stromelysin-1 precursor (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1) (SL-1).

MMP1A_MOUSE
NC score	0.699528 (rank : 27)	θ value	8.11959e-09 (rank : 30)
Query Neighborhood Hits	74	Target Neighborhood Hits	58	Shared Neighborhood Hits	43
SwissProt Accessions	Q9EPL5	Gene names	Mmp1a, McolA
Domain Architecture	No domain graphic available
Description	Interstitial collagenase A precursor (EC 3.4.24.7) (Matrix metalloproteinase-1a) (MMP-1a) (Mcol-A).

MMP21_MOUSE
NC score	0.699118 (rank : 28)	θ value	5.81887e-07 (rank : 36)
Query Neighborhood Hits	74	Target Neighborhood Hits	59	Shared Neighborhood Hits	43
SwissProt Accessions	Q8K3F2	Gene names	Mmp21
Domain Architecture	No domain graphic available
Description	Matrix metalloproteinase-21 precursor (EC 3.4.24.-) (MMP-21).

MMP3_MOUSE
NC score	0.697461 (rank : 29)	θ value	3.08544e-08 (rank : 31)
Query Neighborhood Hits	74	Target Neighborhood Hits	53	Shared Neighborhood Hits	43
SwissProt Accessions	P28862	Gene names	Mmp3
Domain Architecture
Description	Stromelysin-1 precursor (EC 3.4.24.17) (Matrix metalloproteinase-3) (MMP-3) (Transin-1) (SL-1) (EMS-2).

MMP1B_MOUSE
NC score	0.696686 (rank : 30)	θ value	5.26297e-08 (rank : 33)
Query Neighborhood Hits	74	Target Neighborhood Hits	64	Shared Neighborhood Hits	43
SwissProt Accessions	Q9EPL6	Gene names	Mmp1b, McolB
Domain Architecture	No domain graphic available
Description	Interstitial collagenase B precursor (EC 3.4.24.7) (Matrix metalloproteinase-1b) (MMP-1b) (Mcol-B).

MMP13_MOUSE
NC score	0.694723 (rank : 31)	θ value	1.99992e-07 (rank : 35)
Query Neighborhood Hits	74	Target Neighborhood Hits	56	Shared Neighborhood Hits	43
SwissProt Accessions	P33435	Gene names	Mmp13
Domain Architecture
Description	Collagenase 3 precursor (EC 3.4.24.-) (Matrix metalloproteinase-13) (MMP-13).

MMP21_HUMAN
NC score	0.690146 (rank : 32)	θ value	4.92598e-06 (rank : 40)
Query Neighborhood Hits	74	Target Neighborhood Hits	76	Shared Neighborhood Hits	44
SwissProt Accessions	Q8N119, Q8NG02	Gene names	MMP21
Domain Architecture	No domain graphic available
Description	Matrix metalloproteinase-21 precursor (EC 3.4.24.-) (MMP-21).

MMP1_HUMAN
NC score	0.689871 (rank : 33)	θ value	2.79066e-09 (rank : 28)
Query Neighborhood Hits	74	Target Neighborhood Hits	55	Shared Neighborhood Hits	43
SwissProt Accessions	P03956, P08156	Gene names	MMP1, CLG
Domain Architecture
Description	Interstitial collagenase precursor (EC 3.4.24.7) (Matrix metalloproteinase-1) (MMP-1) (Fibroblast collagenase) [Contains: 22 kDa interstitial collagenase; 27 kDa interstitial collagenase].

MMP20_HUMAN
NC score	0.684767 (rank : 34)	θ value	4.1701e-05 (rank : 42)
Query Neighborhood Hits	74	Target Neighborhood Hits	56	Shared Neighborhood Hits	43
SwissProt Accessions	O60882, Q6DKT9	Gene names	MMP20
Domain Architecture
Description	Matrix metalloproteinase-20 precursor (EC 3.4.24.-) (MMP-20) (Enamel metalloproteinase) (Enamelysin).

MMP20_MOUSE
NC score	0.683440 (rank : 35)	θ value	3.19293e-05 (rank : 41)
Query Neighborhood Hits	74	Target Neighborhood Hits	56	Shared Neighborhood Hits	43
SwissProt Accessions	P57748	Gene names	Mmp20
Domain Architecture
Description	Matrix metalloproteinase-20 precursor (EC 3.4.24.-) (MMP-20) (Enamel metalloproteinase) (Enamelysin).

HEMO_HUMAN
NC score	0.677717 (rank : 36)	θ value	1.63604e-09 (rank : 25)
Query Neighborhood Hits	74	Target Neighborhood Hits	47	Shared Neighborhood Hits	43
SwissProt Accessions	P02790	Gene names	HPX
Domain Architecture
Description	Hemopexin precursor (Beta-1B-glycoprotein).

MMP2_MOUSE
NC score	0.661829 (rank : 37)	θ value	1.63604e-09 (rank : 26)
Query Neighborhood Hits	74	Target Neighborhood Hits	77	Shared Neighborhood Hits	43
SwissProt Accessions	P33434	Gene names	Mmp2
Domain Architecture
Description	72 kDa type IV collagenase precursor (EC 3.4.24.24) (72 kDa gelatinase) (Matrix metalloproteinase-2) (MMP-2) (Gelatinase A).

MMP2_HUMAN
NC score	0.660515 (rank : 38)	θ value	2.13673e-09 (rank : 27)
Query Neighborhood Hits	74	Target Neighborhood Hits	79	Shared Neighborhood Hits	43
SwissProt Accessions	P08253	Gene names	MMP2, CLG4A
Domain Architecture
Description	72 kDa type IV collagenase precursor (EC 3.4.24.24) (72 kDa gelatinase) (Matrix metalloproteinase-2) (MMP-2) (Gelatinase A) (TBE- 1).

MMP7_HUMAN
NC score	0.621990 (rank : 39)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	74	Target Neighborhood Hits	49	Shared Neighborhood Hits	37
SwissProt Accessions	P09237, Q9BTK9	Gene names	MMP7, MPSL1, PUMP1
Domain Architecture
Description	Matrilysin precursor (EC 3.4.24.23) (Pump-1 protease) (Uterine metalloproteinase) (Matrix metalloproteinase-7) (MMP-7) (Matrin).

MMP7_MOUSE
NC score	0.619702 (rank : 40)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	74	Target Neighborhood Hits	60	Shared Neighborhood Hits	37
SwissProt Accessions	Q10738	Gene names	Mmp7
Domain Architecture
Description	Matrilysin precursor (EC 3.4.24.23) (Pump-1 protease) (Uterine metalloproteinase) (Matrix metalloproteinase-7) (MMP-7) (Matrin).

MMP26_HUMAN
NC score	0.619467 (rank : 41)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	74	Target Neighborhood Hits	56	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NRE1, Q9GZS2, Q9NR87	Gene names	MMP26
Domain Architecture
Description	Matrix metalloproteinase-26 precursor (EC 3.4.24.-) (MMP-26) (Matrilysin-2) (Endometase).

MMP9_HUMAN
NC score	0.613358 (rank : 42)	θ value	1.29631e-06 (rank : 39)
Query Neighborhood Hits	74	Target Neighborhood Hits	125	Shared Neighborhood Hits	42
SwissProt Accessions	P14780, Q3LR70, Q8N725, Q9H4Z1	Gene names	MMP9, CLG4B
Domain Architecture
Description	Matrix metalloproteinase-9 precursor (EC 3.4.24.35) (MMP-9) (92 kDa type IV collagenase) (92 kDa gelatinase) (Gelatinase B) (GELB) [Contains: 67 kDa matrix metalloproteinase-9; 82 kDa matrix metalloproteinase-9].

HEMO_MOUSE
NC score	0.599346 (rank : 43)	θ value	9.92553e-07 (rank : 37)
Query Neighborhood Hits	74	Target Neighborhood Hits	48	Shared Neighborhood Hits	43
SwissProt Accessions	Q91X72, P97824, Q8WUP0	Gene names	Hpx, Hpxn
Domain Architecture
Description	Hemopexin precursor.

MMP9_MOUSE
NC score	0.588614 (rank : 44)	θ value	0.00509761 (rank : 46)
Query Neighborhood Hits	74	Target Neighborhood Hits	151	Shared Neighborhood Hits	43
SwissProt Accessions	P41245, Q06788, Q9DC02	Gene names	Mmp9, Clg4b
Domain Architecture
Description	Matrix metalloproteinase-9 precursor (EC 3.4.24.35) (MMP-9) (92 kDa type IV collagenase) (92 kDa gelatinase) (Gelatinase B) (GELB).

PRG4_MOUSE
NC score	0.535801 (rank : 45)	θ value	1.37539e-32 (rank : 3)
Query Neighborhood Hits	74	Target Neighborhood Hits	624	Shared Neighborhood Hits	55
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PRG4_HUMAN
NC score	0.472680 (rank : 46)	θ value	8.91499e-32 (rank : 4)
Query Neighborhood Hits	74	Target Neighborhood Hits	764	Shared Neighborhood Hits	54
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PP11_HUMAN
NC score	0.253478 (rank : 47)	θ value	0.0113563 (rank : 48)
Query Neighborhood Hits	74	Target Neighborhood Hits	20	Shared Neighborhood Hits	11
SwissProt Accessions	P21128, Q2NKJ4	Gene names
Domain Architecture
Description	Placental protein 11 precursor (EC 3.4.21.-) (PP11).

ENPP2_HUMAN
NC score	0.166359 (rank : 48)	θ value	0.000602161 (rank : 43)
Query Neighborhood Hits	74	Target Neighborhood Hits	61	Shared Neighborhood Hits	11
SwissProt Accessions	Q13822, Q13827, Q15117	Gene names	ENPP2, ATX, PDNP2
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2) (Phosphodiesterase I/nucleotide pyrophosphatase 2) (Phosphodiesterase I alpha) (PD-Ialpha) (Autotaxin) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP2_MOUSE
NC score	0.165536 (rank : 49)	θ value	0.00102713 (rank : 44)
Query Neighborhood Hits	74	Target Neighborhood Hits	66	Shared Neighborhood Hits	11
SwissProt Accessions	Q9R1E6, Q99LG9	Gene names	Enpp2, Npps2
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2) (Phosphodiesterase I/nucleotide pyrophosphatase 2) (Phosphodiesterase I alpha) (PD-Ialpha) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP1_HUMAN
NC score	0.154892 (rank : 50)	θ value	0.00390308 (rank : 45)
Query Neighborhood Hits	74	Target Neighborhood Hits	47	Shared Neighborhood Hits	12
SwissProt Accessions	P22413, Q5T9R6, Q9NPZ3, Q9P1P6, Q9UP61, Q9Y6K3	Gene names	ENPP1, NPPS, PC1, PDNP1
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP1_MOUSE
NC score	0.154871 (rank : 51)	θ value	0.00869519 (rank : 47)
Query Neighborhood Hits	74	Target Neighborhood Hits	65	Shared Neighborhood Hits	11
SwissProt Accessions	P06802	Gene names	Enpp1, Npps, Pc1, Pdnp1
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) (Antigen Ly-41) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP3_HUMAN
NC score	0.134652 (rank : 52)	θ value	0.47712 (rank : 52)
Query Neighborhood Hits	74	Target Neighborhood Hits	34	Shared Neighborhood Hits	11
SwissProt Accessions	O14638	Gene names	ENPP3, PDNP3
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 3 (E-NPP 3) (Phosphodiesterase I/nucleotide pyrophosphatase 3) (Phosphodiesterase I beta) (PD-Ibeta) (CD203c antigen) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

SPRR3_HUMAN
NC score	0.096610 (rank : 53)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	74	Target Neighborhood Hits	102	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UBC9, O75597, Q4ZGI7, Q5T525, Q8NET7, Q9UDG3	Gene names	SPRR3, SPRC
Domain Architecture
Description	Small proline-rich protein 3 (Cornifin beta) (Esophagin) (22 kDa pancornulin).

SPRR3_MOUSE
NC score	0.080258 (rank : 54)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	74	Target Neighborhood Hits	106	Shared Neighborhood Hits	5
SwissProt Accessions	O09116	Gene names	Sprr3
Domain Architecture
Description	Small proline-rich protein 3 (Cornifin beta).

SPR1B_MOUSE
NC score	0.079709 (rank : 55)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	74	Target Neighborhood Hits	395	Shared Neighborhood Hits	10
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

SPR1A_MOUSE
NC score	0.074004 (rank : 56)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	74	Target Neighborhood Hits	343	Shared Neighborhood Hits	10
SwissProt Accessions	Q62266	Gene names	Sprr1a
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein 1A) (SPR1A) (SPR1 A).

PRAX_HUMAN
NC score	0.071281 (rank : 57)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	74	Target Neighborhood Hits	215	Shared Neighborhood Hits	7
SwissProt Accessions	Q9BXM0, Q9BXL9, Q9HCF2	Gene names	PRX, KIAA1620
Domain Architecture
Description	Periaxin.

ENPP7_HUMAN
NC score	0.063317 (rank : 58)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	74	Target Neighborhood Hits	30	Shared Neighborhood Hits	5
SwissProt Accessions	Q6UWV6, Q6ZTS5, Q8IUS8	Gene names	ENPP7
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 7 precursor (EC 3.1.4.12) (E-NPP7) (NPP-7) (Alkaline sphingomyelin phosphodiesterase) (Intestinal alkaline sphingomyelinase) (Alk-SMase).

ENPP5_HUMAN
NC score	0.061619 (rank : 59)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	74	Target Neighborhood Hits	16	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UJA9, Q6UX49	Gene names	ENPP5
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 5 precursor (EC 3.1.-.-) (E-NPP5) (NPP-5).

ENPP5_MOUSE
NC score	0.061479 (rank : 60)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	74	Target Neighborhood Hits	14	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EQG7, Q921P7	Gene names	Enpp5
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 5 precursor (EC 3.1.-.-) (E-NPP5) (NPP-5).

ENPP6_HUMAN
NC score	0.059948 (rank : 61)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	74	Target Neighborhood Hits	17	Shared Neighborhood Hits	5
SwissProt Accessions	Q6UWR7, Q96M57	Gene names	ENPP6
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 6 precursor (EC 3.1.-.-) (E-NPP6) (NPP-6) [Contains: Ectonucleotide pyrophosphatase/phosphodiesterase 6 soluble form].

ENPP6_MOUSE
NC score	0.059657 (rank : 62)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	74	Target Neighborhood Hits	16	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BGN3, Q4VAH5	Gene names	Enpp6
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 6 precursor (EC 3.1.-.-) (E-NPP6) (NPP-6) [Contains: Ectonucleotide pyrophosphatase/phosphodiesterase 6 soluble form].

BCL7B_MOUSE
NC score	0.057028 (rank : 63)	θ value	0.0961366 (rank : 50)
Query Neighborhood Hits	74	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q921K9, O89022, Q3TV31, Q3U2W0	Gene names	Bcl7b
Domain Architecture	No domain graphic available
Description	B-cell CLL/lymphoma 7 protein family member B.

MDC1_HUMAN
NC score	0.056526 (rank : 64)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	74	Target Neighborhood Hits	1446	Shared Neighborhood Hits	17
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

PRAX_MOUSE
NC score	0.056500 (rank : 65)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	74	Target Neighborhood Hits	199	Shared Neighborhood Hits	5
SwissProt Accessions	O55103, O55104	Gene names	Prx
Domain Architecture
Description	Periaxin.

SEL1L_HUMAN
NC score	0.052909 (rank : 66)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	74	Target Neighborhood Hits	42	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UBV2, Q6UWT6, Q9P1T9, Q9UHK7	Gene names	SEL1L, TSA305
Domain Architecture
Description	Sel-1 homolog precursor (Suppressor of lin-12-like protein) (Sel-1L).

BCL7B_HUMAN
NC score	0.052385 (rank : 67)	θ value	0.279714 (rank : 51)
Query Neighborhood Hits	74	Target Neighborhood Hits	30	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BQE9, O43769, Q13845, Q6ZW75	Gene names	BCL7B
Domain Architecture	No domain graphic available
Description	B-cell CLL/lymphoma 7 protein family member B.

SPR1A_HUMAN
NC score	0.051753 (rank : 68)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	74	Target Neighborhood Hits	136	Shared Neighborhood Hits	6
SwissProt Accessions	P35321, Q9UDG4	Gene names	SPRR1A
Domain Architecture	No domain graphic available
Description	Cornifin A (Small proline-rich protein IA) (SPR-IA) (SPRK) (19 kDa pancornulin).

SEL1L_MOUSE
NC score	0.051355 (rank : 69)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	74	Target Neighborhood Hits	62	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z2G6, Q9DBD8	Gene names	Sel1l, Sel1h
Domain Architecture
Description	Sel-1 homolog precursor (Suppressor of lin-12-like protein) (Sel-1L).

SPR1B_HUMAN
NC score	0.050975 (rank : 70)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	74	Target Neighborhood Hits	102	Shared Neighborhood Hits	4
SwissProt Accessions	P22528, P22529, P22530, Q5T524	Gene names	SPRR1B
Domain Architecture	No domain graphic available
Description	Cornifin B (Small proline-rich protein IB) (SPR-IB) (14.9 kDa pancornulin).

SUSD2_HUMAN
NC score	0.041365 (rank : 71)	θ value	6.88961 (rank : 70)
Query Neighborhood Hits	74	Target Neighborhood Hits	99	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UGT4, Q9H5Y6	Gene names	SUSD2
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 2 precursor.

K1802_MOUSE
NC score	0.038429 (rank : 72)	θ value	0.47712 (rank : 53)
Query Neighborhood Hits	74	Target Neighborhood Hits	1596	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

SYNJ2_MOUSE
NC score	0.030392 (rank : 73)	θ value	0.0431538 (rank : 49)
Query Neighborhood Hits	74	Target Neighborhood Hits	87	Shared Neighborhood Hits	4
SwissProt Accessions	Q9D2G5, O35404, O88399, O88400, O88401, O88402, O88403, O88404	Gene names	Synj2, Kiaa0348
Domain Architecture
Description	Synaptojanin-2 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 2).

T22D2_HUMAN
NC score	0.024096 (rank : 74)	θ value	1.06291 (rank : 55)
Query Neighborhood Hits	74	Target Neighborhood Hits	250	Shared Neighborhood Hits	5
SwissProt Accessions	O75157, Q6PI50, Q9H2Z6, Q9H2Z7, Q9H2Z8	Gene names	TSC22D2, KIAA0669, TILZ4
Domain Architecture	No domain graphic available
Description	TSC22 domain family protein 2 (TSC22-related-inducible leucine zipper protein 4).

AQR_HUMAN
NC score	0.019972 (rank : 75)	θ value	5.27518 (rank : 61)
Query Neighborhood Hits	74	Target Neighborhood Hits	88	Shared Neighborhood Hits	4
SwissProt Accessions	O60306, Q2YDX9, Q6IRU8, Q6PIC8	Gene names	AQR, KIAA0560
Domain Architecture	No domain graphic available
Description	Intron-binding protein aquarius (Intron-binding protein of 160 kDa) (IBP160).

G3BP2_MOUSE
NC score	0.019218 (rank : 76)	θ value	1.81305 (rank : 56)
Query Neighborhood Hits	74	Target Neighborhood Hits	258	Shared Neighborhood Hits	5
SwissProt Accessions	P97379, Q9R1B8	Gene names	G3bp2
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 2 (GAP SH3-domain- binding protein 2) (G3BP-2).

AMPH_HUMAN
NC score	0.017057 (rank : 77)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	74	Target Neighborhood Hits	455	Shared Neighborhood Hits	8
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

G3BP2_HUMAN
NC score	0.015808 (rank : 78)	θ value	5.27518 (rank : 64)
Query Neighborhood Hits	74	Target Neighborhood Hits	260	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UN86, O60606, O75149, Q9UPA1	Gene names	G3BP2, KIAA0660
Domain Architecture
Description	Ras-GTPase-activating protein-binding protein 2 (GAP SH3-domain- binding protein 2) (G3BP-2).

IWS1_MOUSE
NC score	0.014755 (rank : 79)	θ value	8.99809 (rank : 73)
Query Neighborhood Hits	74	Target Neighborhood Hits	1258	Shared Neighborhood Hits	15
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

MADCA_HUMAN
NC score	0.013609 (rank : 80)	θ value	6.88961 (rank : 67)
Query Neighborhood Hits	74	Target Neighborhood Hits	221	Shared Neighborhood Hits	6
SwissProt Accessions	Q13477, O60222, O75867	Gene names	MADCAM1
Domain Architecture	No domain graphic available
Description	Mucosal addressin cell adhesion molecule 1 precursor (MAdCAM-1) (hMAdCAM-1).

TR10C_HUMAN
NC score	0.012351 (rank : 81)	θ value	4.03905 (rank : 60)
Query Neighborhood Hits	74	Target Neighborhood Hits	105	Shared Neighborhood Hits	3
SwissProt Accessions	O14798, O14755, Q6UXM5	Gene names	TNFRSF10C, DCR1, LIT, TRAILR3, TRID
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 10C precursor (Decoy receptor 1) (DcR1) (Decoy TRAIL receptor without death domain) (TNF- related apoptosis-inducing ligand receptor 3) (TRAIL receptor 3) (TRAIL-R3) (Trail receptor without an intracellular domain) (Lymphocyte inhibitor of TRAIL) (Antagonist decoy receptor for TRAIL/Apo-2L) (CD263 antigen).

MAP1B_HUMAN
NC score	0.010407 (rank : 82)	θ value	6.88961 (rank : 68)
Query Neighborhood Hits	74	Target Neighborhood Hits	903	Shared Neighborhood Hits	10
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

OCLN_HUMAN
NC score	0.010342 (rank : 83)	θ value	6.88961 (rank : 69)
Query Neighborhood Hits	74	Target Neighborhood Hits	131	Shared Neighborhood Hits	2
SwissProt Accessions	Q16625, Q8N6K1	Gene names	OCLN
Domain Architecture
Description	Occludin.

CEND3_HUMAN
NC score	0.005099 (rank : 84)	θ value	5.27518 (rank : 62)
Query Neighborhood Hits	74	Target Neighborhood Hits	275	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

IASPP_MOUSE
NC score	0.005067 (rank : 85)	θ value	3.0926 (rank : 59)
Query Neighborhood Hits	74	Target Neighborhood Hits	1024	Shared Neighborhood Hits	7
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

LAMA1_HUMAN
NC score	0.004688 (rank : 86)	θ value	1.06291 (rank : 54)
Query Neighborhood Hits	74	Target Neighborhood Hits	804	Shared Neighborhood Hits	4
SwissProt Accessions	P25391	Gene names	LAMA1, LAMA
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

ETV4_MOUSE
NC score	0.003662 (rank : 87)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	74	Target Neighborhood Hits	100	Shared Neighborhood Hits	3
SwissProt Accessions	P28322	Gene names	Etv4, Pea-3, Pea3
Domain Architecture
Description	ETS translocation variant 4 (Polyomavirus enhancer activator 3) (Protein PEA3).

FOXC1_HUMAN
NC score	0.003380 (rank : 88)	θ value	5.27518 (rank : 63)
Query Neighborhood Hits	74	Target Neighborhood Hits	208	Shared Neighborhood Hits	5
SwissProt Accessions	Q12948, Q86UP7, Q9BYM1, Q9NUE5, Q9UDD0, Q9UP06	Gene names	FOXC1, FKHL7, FREAC3
Domain Architecture
Description	Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead- related transcription factor 3) (FREAC-3).

MYST3_MOUSE
NC score	0.002591 (rank : 89)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	74	Target Neighborhood Hits	688	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

HA11_MOUSE
NC score	-0.000278 (rank : 90)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	74	Target Neighborhood Hits	217	Shared Neighborhood Hits	3
SwissProt Accessions	P01899	Gene names	H2-D1
Domain Architecture
Description	H-2 class I histocompatibility antigen, D-B alpha chain precursor (H- 2D(B)).

ATBF1_HUMAN
NC score	-0.001082 (rank : 91)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	74	Target Neighborhood Hits	1547	Shared Neighborhood Hits	8
SwissProt Accessions	Q15911, O15101, Q13719	Gene names	ATBF1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

FAK2_HUMAN
NC score	-0.001457 (rank : 92)	θ value	2.36792 (rank : 57)
Query Neighborhood Hits	74	Target Neighborhood Hits	847	Shared Neighborhood Hits	4
SwissProt Accessions	Q14289, Q13475, Q14290, Q16709	Gene names	PTK2B, FAK2, PYK2, RAFTK
Domain Architecture
Description	Protein tyrosine kinase 2 beta (EC 2.7.10.2) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Cell adhesion kinase beta) (CAK beta) (Calcium-dependent tyrosine kinase) (CADTK) (Related adhesion focal tyrosine kinase) (RAFTK).

NEK11_HUMAN
NC score	-0.002715 (rank : 93)	θ value	2.36792 (rank : 58)
Query Neighborhood Hits	74	Target Neighborhood Hits	1043	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NG66, Q5JPC0, Q8NG65, Q8TBY1, Q9H5F4	Gene names	NEK11
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase Nek11 (EC 2.7.11.1) (NimA-related protein kinase 11) (Never in mitosis A-related kinase 11).