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Network neighborhood for query Sequence : ENPP2_HUMAN

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ENPP2_HUMAN
SwissProt Accessions	Q13822, Q13827, Q15117	Gene names	ENPP2, ATX, PDNP2
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2) (Phosphodiesterase I/nucleotide pyrophosphatase 2) (Phosphodiesterase I alpha) (PD-Ialpha) (Autotaxin) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ENPP1_HUMAN
θ value	0 (rank : 1)	NC score	0.975312 (rank : 4)
Query Neighborhood Hits	61	Target Neighborhood Hits	47	Shared Neighborhood Hits	26
SwissProt Accessions	P22413, Q5T9R6, Q9NPZ3, Q9P1P6, Q9UP61, Q9Y6K3	Gene names	ENPP1, NPPS, PC1, PDNP1
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP1_MOUSE
θ value	0 (rank : 2)	NC score	0.973729 (rank : 5)
Query Neighborhood Hits	61	Target Neighborhood Hits	65	Shared Neighborhood Hits	25
SwissProt Accessions	P06802	Gene names	Enpp1, Npps, Pc1, Pdnp1
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) (Antigen Ly-41) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP2_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	61	Target Neighborhood Hits	61	Shared Neighborhood Hits	61
SwissProt Accessions	Q13822, Q13827, Q15117	Gene names	ENPP2, ATX, PDNP2
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2) (Phosphodiesterase I/nucleotide pyrophosphatase 2) (Phosphodiesterase I alpha) (PD-Ialpha) (Autotaxin) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP2_MOUSE
θ value	0 (rank : 4)	NC score	0.997442 (rank : 2)
Query Neighborhood Hits	61	Target Neighborhood Hits	66	Shared Neighborhood Hits	50
SwissProt Accessions	Q9R1E6, Q99LG9	Gene names	Enpp2, Npps2
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2) (Phosphodiesterase I/nucleotide pyrophosphatase 2) (Phosphodiesterase I alpha) (PD-Ialpha) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP3_HUMAN
θ value	0 (rank : 5)	NC score	0.978302 (rank : 3)
Query Neighborhood Hits	61	Target Neighborhood Hits	34	Shared Neighborhood Hits	20
SwissProt Accessions	O14638	Gene names	ENPP3, PDNP3
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 3 (E-NPP 3) (Phosphodiesterase I/nucleotide pyrophosphatase 3) (Phosphodiesterase I beta) (PD-Ibeta) (CD203c antigen) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP5_MOUSE
θ value	6.7944e-48 (rank : 6)	NC score	0.867487 (rank : 8)
Query Neighborhood Hits	61	Target Neighborhood Hits	14	Shared Neighborhood Hits	12
SwissProt Accessions	Q9EQG7, Q921P7	Gene names	Enpp5
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 5 precursor (EC 3.1.-.-) (E-NPP5) (NPP-5).

ENPP5_HUMAN
θ value	2.58187e-47 (rank : 7)	NC score	0.867671 (rank : 7)
Query Neighborhood Hits	61	Target Neighborhood Hits	16	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UJA9, Q6UX49	Gene names	ENPP5
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 5 precursor (EC 3.1.-.-) (E-NPP5) (NPP-5).

ENPP6_MOUSE
θ value	4.86918e-46 (rank : 8)	NC score	0.853667 (rank : 10)
Query Neighborhood Hits	61	Target Neighborhood Hits	16	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BGN3, Q4VAH5	Gene names	Enpp6
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 6 precursor (EC 3.1.-.-) (E-NPP6) (NPP-6) [Contains: Ectonucleotide pyrophosphatase/phosphodiesterase 6 soluble form].

ENPP6_HUMAN
θ value	1.85029e-45 (rank : 9)	NC score	0.854370 (rank : 9)
Query Neighborhood Hits	61	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	Q6UWR7, Q96M57	Gene names	ENPP6
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 6 precursor (EC 3.1.-.-) (E-NPP6) (NPP-6) [Contains: Ectonucleotide pyrophosphatase/phosphodiesterase 6 soluble form].

ENPP7_HUMAN
θ value	7.03111e-45 (rank : 10)	NC score	0.875918 (rank : 6)
Query Neighborhood Hits	61	Target Neighborhood Hits	30	Shared Neighborhood Hits	14
SwissProt Accessions	Q6UWV6, Q6ZTS5, Q8IUS8	Gene names	ENPP7
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 7 precursor (EC 3.1.4.12) (E-NPP7) (NPP-7) (Alkaline sphingomyelin phosphodiesterase) (Intestinal alkaline sphingomyelinase) (Alk-SMase).

PRG4_MOUSE
θ value	1.06045e-08 (rank : 11)	NC score	0.203432 (rank : 12)
Query Neighborhood Hits	61	Target Neighborhood Hits	624	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PRG4_HUMAN
θ value	5.81887e-07 (rank : 12)	NC score	0.180694 (rank : 13)
Query Neighborhood Hits	61	Target Neighborhood Hits	764	Shared Neighborhood Hits	16
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

VTNC_MOUSE
θ value	0.000602161 (rank : 13)	NC score	0.166359 (rank : 15)
Query Neighborhood Hits	61	Target Neighborhood Hits	74	Shared Neighborhood Hits	11
SwissProt Accessions	P29788, Q8VII4	Gene names	Vtn
Domain Architecture
Description	Vitronectin precursor (Serum-spreading factor) (S-protein).

VTNC_HUMAN
θ value	0.00228821 (rank : 14)	NC score	0.159347 (rank : 17)
Query Neighborhood Hits	61	Target Neighborhood Hits	66	Shared Neighborhood Hits	12
SwissProt Accessions	P04004, P01141, Q9BSH7	Gene names	VTN
Domain Architecture
Description	Vitronectin precursor (Serum-spreading factor) (S-protein) (V75) [Contains: Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin B].

PP11_HUMAN
θ value	0.00390308 (rank : 15)	NC score	0.300294 (rank : 11)
Query Neighborhood Hits	61	Target Neighborhood Hits	20	Shared Neighborhood Hits	12
SwissProt Accessions	P21128, Q2NKJ4	Gene names
Domain Architecture
Description	Placental protein 11 precursor (EC 3.4.21.-) (PP11).

PIGO_HUMAN
θ value	0.00509761 (rank : 16)	NC score	0.169607 (rank : 14)
Query Neighborhood Hits	61	Target Neighborhood Hits	24	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TEQ8, Q6P154, Q6UX80, Q8TDS8, Q96CS9, Q9BVN9, Q9Y4B0	Gene names	PIGO
Domain Architecture
Description	GPI ethanolamine phosphate transferase 3 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class O protein) (PIG-O).

PIGO_MOUSE
θ value	0.00509761 (rank : 17)	NC score	0.163690 (rank : 16)
Query Neighborhood Hits	61	Target Neighborhood Hits	21	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JJI6, Q9CRY2	Gene names	Pigo
Domain Architecture
Description	GPI ethanolamine phosphate transferase 3 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class O protein) (PIG-O).

LTBP2_HUMAN
θ value	0.00869519 (rank : 18)	NC score	0.046659 (rank : 26)
Query Neighborhood Hits	61	Target Neighborhood Hits	552	Shared Neighborhood Hits	30
SwissProt Accessions	Q14767, Q99907, Q9NS51	Gene names	LTBP2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

KRA59_HUMAN
θ value	0.0330416 (rank : 19)	NC score	0.068802 (rank : 22)
Query Neighborhood Hits	61	Target Neighborhood Hits	310	Shared Neighborhood Hits	28
SwissProt Accessions	P26371, Q14564	Gene names	KRTAP5-9, KAP5.9, KRN1, KRTAP5.9, UHSK1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-9 (Keratin-associated protein 5.9) (Ultrahigh sulfur keratin-associated protein 5.9) (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (UHS keratin A) (UHS KerA).

ARSA_HUMAN
θ value	0.125558 (rank : 20)	NC score	0.050483 (rank : 25)
Query Neighborhood Hits	61	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	P15289, Q6ICI5, Q96CJ0	Gene names	ARSA
Domain Architecture
Description	Arylsulfatase A precursor (EC 3.1.6.8) (ASA) (Cerebroside-sulfatase) [Contains: Arylsulfatase A component B; Arylsulfatase A component C].

ADA28_HUMAN
θ value	0.163984 (rank : 21)	NC score	0.024121 (rank : 55)
Query Neighborhood Hits	61	Target Neighborhood Hits	244	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UKQ2, Q9Y339, Q9Y3S0	Gene names	ADAM28, MDCL
Domain Architecture
Description	ADAM 28 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 28) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein-L) (MDC-L) (eMDC II) (ADAM23).

CNBP_MOUSE
θ value	0.163984 (rank : 22)	NC score	0.046019 (rank : 27)
Query Neighborhood Hits	61	Target Neighborhood Hits	215	Shared Neighborhood Hits	3
SwissProt Accessions	P53996, Q80Y06, Q8BP23	Gene names	Cnbp, Cnbp1, Znf9
Domain Architecture	No domain graphic available
Description	Cellular nucleic acid-binding protein (CNBP) (Zinc finger protein 9).

LTBP2_MOUSE
θ value	0.163984 (rank : 23)	NC score	0.042109 (rank : 29)
Query Neighborhood Hits	61	Target Neighborhood Hits	617	Shared Neighborhood Hits	29
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

FBN2_HUMAN
θ value	0.21417 (rank : 24)	NC score	0.039617 (rank : 31)
Query Neighborhood Hits	61	Target Neighborhood Hits	560	Shared Neighborhood Hits	30
SwissProt Accessions	P35556	Gene names	FBN2
Domain Architecture
Description	Fibrillin-2 precursor.

FSTL5_HUMAN
θ value	0.279714 (rank : 25)	NC score	0.030889 (rank : 41)
Query Neighborhood Hits	61	Target Neighborhood Hits	347	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

TECTA_MOUSE
θ value	0.365318 (rank : 26)	NC score	0.032264 (rank : 37)
Query Neighborhood Hits	61	Target Neighborhood Hits	244	Shared Neighborhood Hits	27
SwissProt Accessions	O08523	Gene names	Tecta
Domain Architecture
Description	Alpha-tectorin precursor.

NOTC4_MOUSE
θ value	0.47712 (rank : 27)	NC score	0.030344 (rank : 43)
Query Neighborhood Hits	61	Target Neighborhood Hits	872	Shared Neighborhood Hits	33
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

LRP1B_HUMAN
θ value	0.62314 (rank : 28)	NC score	0.033763 (rank : 36)
Query Neighborhood Hits	61	Target Neighborhood Hits	602	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

SUSD2_HUMAN
θ value	0.62314 (rank : 29)	NC score	0.095304 (rank : 19)
Query Neighborhood Hits	61	Target Neighborhood Hits	99	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UGT4, Q9H5Y6	Gene names	SUSD2
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 2 precursor.

TINAG_HUMAN
θ value	0.62314 (rank : 30)	NC score	0.080230 (rank : 20)
Query Neighborhood Hits	61	Target Neighborhood Hits	63	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UJW2, Q9UJW1, Q9ULZ4	Gene names	TINAG
Domain Architecture
Description	Tubulointerstitial nephritis antigen (TIN-Ag).

ARSA_MOUSE
θ value	0.813845 (rank : 31)	NC score	0.039403 (rank : 32)
Query Neighborhood Hits	61	Target Neighborhood Hits	30	Shared Neighborhood Hits	6
SwissProt Accessions	P50428	Gene names	Arsa, As2
Domain Architecture
Description	Arylsulfatase A precursor (EC 3.1.6.8) (ASA) (Cerebroside-sulfatase).

MEGF6_HUMAN
θ value	0.813845 (rank : 32)	NC score	0.031965 (rank : 38)
Query Neighborhood Hits	61	Target Neighborhood Hits	671	Shared Neighborhood Hits	30
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

FSTL4_HUMAN
θ value	1.06291 (rank : 33)	NC score	0.027427 (rank : 48)
Query Neighborhood Hits	61	Target Neighborhood Hits	344	Shared Neighborhood Hits	12
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

CASC5_MOUSE
θ value	1.38821 (rank : 34)	NC score	0.021983 (rank : 57)
Query Neighborhood Hits	61	Target Neighborhood Hits	70	Shared Neighborhood Hits	2
SwissProt Accessions	Q66JQ7, Q8CCH6, Q9CV38	Gene names	Casc5
Domain Architecture	No domain graphic available
Description	Protein CASC5 (Cancer susceptibility candidate gene 5 protein homolog).

FBN2_MOUSE
θ value	1.38821 (rank : 35)	NC score	0.036746 (rank : 33)
Query Neighborhood Hits	61	Target Neighborhood Hits	549	Shared Neighborhood Hits	31
SwissProt Accessions	Q61555, Q63957	Gene names	Fbn2, Fbn-2
Domain Architecture
Description	Fibrillin-2 precursor.

FSTL4_MOUSE
θ value	1.38821 (rank : 36)	NC score	0.026363 (rank : 50)
Query Neighborhood Hits	61	Target Neighborhood Hits	333	Shared Neighborhood Hits	9
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

SCUB3_MOUSE
θ value	1.81305 (rank : 37)	NC score	0.031382 (rank : 40)
Query Neighborhood Hits	61	Target Neighborhood Hits	442	Shared Neighborhood Hits	26
SwissProt Accessions	Q66PY1, Q68FG9	Gene names	Scube3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

ARSF_HUMAN
θ value	2.36792 (rank : 38)	NC score	0.029185 (rank : 44)
Query Neighborhood Hits	61	Target Neighborhood Hits	33	Shared Neighborhood Hits	8
SwissProt Accessions	P54793, Q8TCC5	Gene names	ARSF
Domain Architecture
Description	Arylsulfatase F precursor (EC 3.1.6.-) (ASF).

KRA58_HUMAN
θ value	2.36792 (rank : 39)	NC score	0.045648 (rank : 28)
Query Neighborhood Hits	61	Target Neighborhood Hits	324	Shared Neighborhood Hits	28
SwissProt Accessions	O75690, Q6L8G7, Q6UTX6	Gene names	KRTAP5-8, KAP5.8, KRTAP5.8, UHSKB
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-8 (Keratin-associated protein 5.8) (Ultrahigh sulfur keratin-associated protein 5.8) (Keratin, ultra high-sulfur matrix protein B) (UHS keratin B) (UHS KerB).

SUSD2_MOUSE
θ value	2.36792 (rank : 40)	NC score	0.078811 (rank : 21)
Query Neighborhood Hits	61	Target Neighborhood Hits	104	Shared Neighborhood Hits	13
SwissProt Accessions	Q9DBX3, Q8BY19, Q8BYN0, Q8BYZ3, Q8BYZ9, Q8BZQ4, Q8C179	Gene names	Susd2
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 2 precursor.

FBN1_HUMAN
θ value	3.0926 (rank : 41)	NC score	0.036036 (rank : 34)
Query Neighborhood Hits	61	Target Neighborhood Hits	557	Shared Neighborhood Hits	31
SwissProt Accessions	P35555, Q15972, Q75N87	Gene names	FBN1, FBN
Domain Architecture
Description	Fibrillin-1 precursor.

WFDC8_HUMAN
θ value	3.0926 (rank : 42)	NC score	0.030421 (rank : 42)
Query Neighborhood Hits	61	Target Neighborhood Hits	82	Shared Neighborhood Hits	10
SwissProt Accessions	Q8IUA0, Q5TDV2, Q96A34	Gene names	WFDC8, C20orf170, WAP8
Domain Architecture
Description	WAP four-disulfide core domain protein 8 precursor (Putative protease inhibitor WAP8).

ADA28_MOUSE
θ value	4.03905 (rank : 43)	NC score	0.014548 (rank : 61)
Query Neighborhood Hits	61	Target Neighborhood Hits	241	Shared Neighborhood Hits	24
SwissProt Accessions	Q9JLN6, Q8K5D2, Q8K5D3	Gene names	Adam28
Domain Architecture
Description	ADAM 28 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 28) (Thymic epithelial cell-ADAM) (TECADAM).

ADAM2_HUMAN
θ value	4.03905 (rank : 44)	NC score	0.014597 (rank : 60)
Query Neighborhood Hits	61	Target Neighborhood Hits	175	Shared Neighborhood Hits	21
SwissProt Accessions	Q99965, P78326, Q9UQQ8	Gene names	ADAM2, FTNB
Domain Architecture
Description	ADAM 2 precursor (A disintegrin and metalloproteinase domain 2) (Fertilin subunit beta) (PH-30) (PH30).

FBN1_MOUSE
θ value	4.03905 (rank : 45)	NC score	0.034509 (rank : 35)
Query Neighborhood Hits	61	Target Neighborhood Hits	563	Shared Neighborhood Hits	30
SwissProt Accessions	Q61554, Q60826	Gene names	Fbn1, Fbn-1
Domain Architecture
Description	Fibrillin-1 precursor.

GRN_HUMAN
θ value	4.03905 (rank : 46)	NC score	0.040245 (rank : 30)
Query Neighborhood Hits	61	Target Neighborhood Hits	268	Shared Neighborhood Hits	29
SwissProt Accessions	P28799, P23781, P23782, P23783, P23784, Q9BWE7, Q9UCH0	Gene names	GRN
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin; Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)].

LRP2_HUMAN
θ value	4.03905 (rank : 47)	NC score	0.031911 (rank : 39)
Query Neighborhood Hits	61	Target Neighborhood Hits	573	Shared Neighborhood Hits	33
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

NOTC1_HUMAN
θ value	5.27518 (rank : 48)	NC score	0.024200 (rank : 54)
Query Neighborhood Hits	61	Target Neighborhood Hits	906	Shared Neighborhood Hits	33
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

NOTC2_MOUSE
θ value	5.27518 (rank : 49)	NC score	0.026899 (rank : 49)
Query Neighborhood Hits	61	Target Neighborhood Hits	1069	Shared Neighborhood Hits	36
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

NOTC4_HUMAN
θ value	5.27518 (rank : 50)	NC score	0.024685 (rank : 52)
Query Neighborhood Hits	61	Target Neighborhood Hits	905	Shared Neighborhood Hits	31
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

ABTB2_HUMAN
θ value	6.88961 (rank : 51)	NC score	0.007809 (rank : 63)
Query Neighborhood Hits	61	Target Neighborhood Hits	391	Shared Neighborhood Hits	8
SwissProt Accessions	Q8N961, Q6MZW4, Q8NB44	Gene names	ABTB2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

ABTB2_MOUSE
θ value	6.88961 (rank : 52)	NC score	0.007639 (rank : 64)
Query Neighborhood Hits	61	Target Neighborhood Hits	414	Shared Neighborhood Hits	7
SwissProt Accessions	Q7TQI7	Gene names	Abtb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

AGRIN_HUMAN
θ value	6.88961 (rank : 53)	NC score	0.023005 (rank : 56)
Query Neighborhood Hits	61	Target Neighborhood Hits	582	Shared Neighborhood Hits	32
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

LRP1B_MOUSE
θ value	6.88961 (rank : 54)	NC score	0.028572 (rank : 45)
Query Neighborhood Hits	61	Target Neighborhood Hits	606	Shared Neighborhood Hits	34
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

LRP1_HUMAN
θ value	6.88961 (rank : 55)	NC score	0.026073 (rank : 51)
Query Neighborhood Hits	61	Target Neighborhood Hits	617	Shared Neighborhood Hits	31
SwissProt Accessions	Q07954, Q2PP12, Q8IVG8	Gene names	LRP1, A2MR
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1 precursor (LRP) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD91 antigen).

SCUB3_HUMAN
θ value	6.88961 (rank : 56)	NC score	0.028397 (rank : 46)
Query Neighborhood Hits	61	Target Neighborhood Hits	428	Shared Neighborhood Hits	25
SwissProt Accessions	Q8IX30, Q5CZB3, Q86UZ9, Q8NAU9	Gene names	SCUBE3, CEGF3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

KRA45_HUMAN
θ value	8.99809 (rank : 57)	NC score	0.018396 (rank : 58)
Query Neighborhood Hits	61	Target Neighborhood Hits	194	Shared Neighborhood Hits	22
SwissProt Accessions	Q9BYR2	Gene names	KRTAP4-5, KAP4.5, KRTAP4.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-5 (Keratin-associated protein 4.5) (Ultrahigh sulfur keratin-associated protein 4.5).

KRA52_HUMAN
θ value	8.99809 (rank : 58)	NC score	0.018186 (rank : 59)
Query Neighborhood Hits	61	Target Neighborhood Hits	236	Shared Neighborhood Hits	23
SwissProt Accessions	Q701N4	Gene names	KRTAP5-2, KAP5-8, KAP5.2, KRTAP5-8, KRTAP5.2, KRTAP5.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-2 (Keratin-associated protein 5.2) (Ultrahigh sulfur keratin-associated protein 5.2) (Keratin-associated protein 5-8) (Keratin-associated protein 5.8).

MT1X_HUMAN
θ value	8.99809 (rank : 59)	NC score	0.009487 (rank : 62)
Query Neighborhood Hits	61	Target Neighborhood Hits	76	Shared Neighborhood Hits	4
SwissProt Accessions	P80297	Gene names	MT1X
Domain Architecture	No domain graphic available
Description	Metallothionein-1X (MT-1X) (Metallothionein-IX) (MT-IX).

NOTC1_MOUSE
θ value	8.99809 (rank : 60)	NC score	0.024423 (rank : 53)
Query Neighborhood Hits	61	Target Neighborhood Hits	916	Shared Neighborhood Hits	31
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

STS_MOUSE
θ value	8.99809 (rank : 61)	NC score	0.027605 (rank : 47)
Query Neighborhood Hits	61	Target Neighborhood Hits	38	Shared Neighborhood Hits	8
SwissProt Accessions	P50427	Gene names	Sts
Domain Architecture
Description	Steryl-sulfatase precursor (EC 3.1.6.2) (Steroid sulfatase) (Steryl- sulfate sulfohydrolase) (Arylsulfatase C) (ASC).

PIGG_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.134067 (rank : 18)
Query Neighborhood Hits	61	Target Neighborhood Hits	27	Shared Neighborhood Hits	9
SwissProt Accessions	Q5H8A4, Q2TAK5, Q6UX31, Q7L5Y4, Q8N866, Q8NCC9, Q96SY9, Q9BVT7, Q9NXG5	Gene names	PIGG, GPI7
Domain Architecture	No domain graphic available
Description	GPI ethanolamine phosphate transferase 2 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class G protein) (PIG-G) (GPI7 homolog) (hGPI7).

PIGN_HUMAN
θ value	θ > 10 (rank : 63)	NC score	0.053783 (rank : 24)
Query Neighborhood Hits	61	Target Neighborhood Hits	19	Shared Neighborhood Hits	7
SwissProt Accessions	O95427, Q7L8F8, Q8TC01, Q9NT05	Gene names	PIGN, MCD4
Domain Architecture	No domain graphic available
Description	GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class N protein) (PIG-N) (MCD4 homolog).

PIGN_MOUSE
θ value	θ > 10 (rank : 64)	NC score	0.062602 (rank : 23)
Query Neighborhood Hits	61	Target Neighborhood Hits	29	Shared Neighborhood Hits	7
SwissProt Accessions	Q9R1S3, Q3V0S6, Q8VCC3, Q9R1S1, Q9R1S2	Gene names	Pign
Domain Architecture	No domain graphic available
Description	GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class N protein) (PIG-N).

Hits sorted by NC score

ENPP2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	61	Target Neighborhood Hits	61	Shared Neighborhood Hits	61
SwissProt Accessions	Q13822, Q13827, Q15117	Gene names	ENPP2, ATX, PDNP2
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2) (Phosphodiesterase I/nucleotide pyrophosphatase 2) (Phosphodiesterase I alpha) (PD-Ialpha) (Autotaxin) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP2_MOUSE
NC score	0.997442 (rank : 2)	θ value	0 (rank : 4)
Query Neighborhood Hits	61	Target Neighborhood Hits	66	Shared Neighborhood Hits	50
SwissProt Accessions	Q9R1E6, Q99LG9	Gene names	Enpp2, Npps2
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2) (Phosphodiesterase I/nucleotide pyrophosphatase 2) (Phosphodiesterase I alpha) (PD-Ialpha) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP3_HUMAN
NC score	0.978302 (rank : 3)	θ value	0 (rank : 5)
Query Neighborhood Hits	61	Target Neighborhood Hits	34	Shared Neighborhood Hits	20
SwissProt Accessions	O14638	Gene names	ENPP3, PDNP3
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 3 (E-NPP 3) (Phosphodiesterase I/nucleotide pyrophosphatase 3) (Phosphodiesterase I beta) (PD-Ibeta) (CD203c antigen) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP1_HUMAN
NC score	0.975312 (rank : 4)	θ value	0 (rank : 1)
Query Neighborhood Hits	61	Target Neighborhood Hits	47	Shared Neighborhood Hits	26
SwissProt Accessions	P22413, Q5T9R6, Q9NPZ3, Q9P1P6, Q9UP61, Q9Y6K3	Gene names	ENPP1, NPPS, PC1, PDNP1
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP1_MOUSE
NC score	0.973729 (rank : 5)	θ value	0 (rank : 2)
Query Neighborhood Hits	61	Target Neighborhood Hits	65	Shared Neighborhood Hits	25
SwissProt Accessions	P06802	Gene names	Enpp1, Npps, Pc1, Pdnp1
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) (Antigen Ly-41) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP7_HUMAN
NC score	0.875918 (rank : 6)	θ value	7.03111e-45 (rank : 10)
Query Neighborhood Hits	61	Target Neighborhood Hits	30	Shared Neighborhood Hits	14
SwissProt Accessions	Q6UWV6, Q6ZTS5, Q8IUS8	Gene names	ENPP7
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 7 precursor (EC 3.1.4.12) (E-NPP7) (NPP-7) (Alkaline sphingomyelin phosphodiesterase) (Intestinal alkaline sphingomyelinase) (Alk-SMase).

ENPP5_HUMAN
NC score	0.867671 (rank : 7)	θ value	2.58187e-47 (rank : 7)
Query Neighborhood Hits	61	Target Neighborhood Hits	16	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UJA9, Q6UX49	Gene names	ENPP5
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 5 precursor (EC 3.1.-.-) (E-NPP5) (NPP-5).

ENPP5_MOUSE
NC score	0.867487 (rank : 8)	θ value	6.7944e-48 (rank : 6)
Query Neighborhood Hits	61	Target Neighborhood Hits	14	Shared Neighborhood Hits	12
SwissProt Accessions	Q9EQG7, Q921P7	Gene names	Enpp5
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 5 precursor (EC 3.1.-.-) (E-NPP5) (NPP-5).

ENPP6_HUMAN
NC score	0.854370 (rank : 9)	θ value	1.85029e-45 (rank : 9)
Query Neighborhood Hits	61	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	Q6UWR7, Q96M57	Gene names	ENPP6
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 6 precursor (EC 3.1.-.-) (E-NPP6) (NPP-6) [Contains: Ectonucleotide pyrophosphatase/phosphodiesterase 6 soluble form].

ENPP6_MOUSE
NC score	0.853667 (rank : 10)	θ value	4.86918e-46 (rank : 8)
Query Neighborhood Hits	61	Target Neighborhood Hits	16	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BGN3, Q4VAH5	Gene names	Enpp6
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 6 precursor (EC 3.1.-.-) (E-NPP6) (NPP-6) [Contains: Ectonucleotide pyrophosphatase/phosphodiesterase 6 soluble form].

PP11_HUMAN
NC score	0.300294 (rank : 11)	θ value	0.00390308 (rank : 15)
Query Neighborhood Hits	61	Target Neighborhood Hits	20	Shared Neighborhood Hits	12
SwissProt Accessions	P21128, Q2NKJ4	Gene names
Domain Architecture
Description	Placental protein 11 precursor (EC 3.4.21.-) (PP11).

PRG4_MOUSE
NC score	0.203432 (rank : 12)	θ value	1.06045e-08 (rank : 11)
Query Neighborhood Hits	61	Target Neighborhood Hits	624	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PRG4_HUMAN
NC score	0.180694 (rank : 13)	θ value	5.81887e-07 (rank : 12)
Query Neighborhood Hits	61	Target Neighborhood Hits	764	Shared Neighborhood Hits	16
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PIGO_HUMAN
NC score	0.169607 (rank : 14)	θ value	0.00509761 (rank : 16)
Query Neighborhood Hits	61	Target Neighborhood Hits	24	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TEQ8, Q6P154, Q6UX80, Q8TDS8, Q96CS9, Q9BVN9, Q9Y4B0	Gene names	PIGO
Domain Architecture
Description	GPI ethanolamine phosphate transferase 3 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class O protein) (PIG-O).

VTNC_MOUSE
NC score	0.166359 (rank : 15)	θ value	0.000602161 (rank : 13)
Query Neighborhood Hits	61	Target Neighborhood Hits	74	Shared Neighborhood Hits	11
SwissProt Accessions	P29788, Q8VII4	Gene names	Vtn
Domain Architecture
Description	Vitronectin precursor (Serum-spreading factor) (S-protein).

PIGO_MOUSE
NC score	0.163690 (rank : 16)	θ value	0.00509761 (rank : 17)
Query Neighborhood Hits	61	Target Neighborhood Hits	21	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JJI6, Q9CRY2	Gene names	Pigo
Domain Architecture
Description	GPI ethanolamine phosphate transferase 3 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class O protein) (PIG-O).

VTNC_HUMAN
NC score	0.159347 (rank : 17)	θ value	0.00228821 (rank : 14)
Query Neighborhood Hits	61	Target Neighborhood Hits	66	Shared Neighborhood Hits	12
SwissProt Accessions	P04004, P01141, Q9BSH7	Gene names	VTN
Domain Architecture
Description	Vitronectin precursor (Serum-spreading factor) (S-protein) (V75) [Contains: Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin B].

PIGG_HUMAN
NC score	0.134067 (rank : 18)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	61	Target Neighborhood Hits	27	Shared Neighborhood Hits	9
SwissProt Accessions	Q5H8A4, Q2TAK5, Q6UX31, Q7L5Y4, Q8N866, Q8NCC9, Q96SY9, Q9BVT7, Q9NXG5	Gene names	PIGG, GPI7
Domain Architecture	No domain graphic available
Description	GPI ethanolamine phosphate transferase 2 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class G protein) (PIG-G) (GPI7 homolog) (hGPI7).

SUSD2_HUMAN
NC score	0.095304 (rank : 19)	θ value	0.62314 (rank : 29)
Query Neighborhood Hits	61	Target Neighborhood Hits	99	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UGT4, Q9H5Y6	Gene names	SUSD2
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 2 precursor.

TINAG_HUMAN
NC score	0.080230 (rank : 20)	θ value	0.62314 (rank : 30)
Query Neighborhood Hits	61	Target Neighborhood Hits	63	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UJW2, Q9UJW1, Q9ULZ4	Gene names	TINAG
Domain Architecture
Description	Tubulointerstitial nephritis antigen (TIN-Ag).

SUSD2_MOUSE
NC score	0.078811 (rank : 21)	θ value	2.36792 (rank : 40)
Query Neighborhood Hits	61	Target Neighborhood Hits	104	Shared Neighborhood Hits	13
SwissProt Accessions	Q9DBX3, Q8BY19, Q8BYN0, Q8BYZ3, Q8BYZ9, Q8BZQ4, Q8C179	Gene names	Susd2
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 2 precursor.

KRA59_HUMAN
NC score	0.068802 (rank : 22)	θ value	0.0330416 (rank : 19)
Query Neighborhood Hits	61	Target Neighborhood Hits	310	Shared Neighborhood Hits	28
SwissProt Accessions	P26371, Q14564	Gene names	KRTAP5-9, KAP5.9, KRN1, KRTAP5.9, UHSK1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-9 (Keratin-associated protein 5.9) (Ultrahigh sulfur keratin-associated protein 5.9) (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (UHS keratin A) (UHS KerA).

PIGN_MOUSE
NC score	0.062602 (rank : 23)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	61	Target Neighborhood Hits	29	Shared Neighborhood Hits	7
SwissProt Accessions	Q9R1S3, Q3V0S6, Q8VCC3, Q9R1S1, Q9R1S2	Gene names	Pign
Domain Architecture	No domain graphic available
Description	GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class N protein) (PIG-N).

PIGN_HUMAN
NC score	0.053783 (rank : 24)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	61	Target Neighborhood Hits	19	Shared Neighborhood Hits	7
SwissProt Accessions	O95427, Q7L8F8, Q8TC01, Q9NT05	Gene names	PIGN, MCD4
Domain Architecture	No domain graphic available
Description	GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class N protein) (PIG-N) (MCD4 homolog).

ARSA_HUMAN
NC score	0.050483 (rank : 25)	θ value	0.125558 (rank : 20)
Query Neighborhood Hits	61	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	P15289, Q6ICI5, Q96CJ0	Gene names	ARSA
Domain Architecture
Description	Arylsulfatase A precursor (EC 3.1.6.8) (ASA) (Cerebroside-sulfatase) [Contains: Arylsulfatase A component B; Arylsulfatase A component C].

LTBP2_HUMAN
NC score	0.046659 (rank : 26)	θ value	0.00869519 (rank : 18)
Query Neighborhood Hits	61	Target Neighborhood Hits	552	Shared Neighborhood Hits	30
SwissProt Accessions	Q14767, Q99907, Q9NS51	Gene names	LTBP2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

CNBP_MOUSE
NC score	0.046019 (rank : 27)	θ value	0.163984 (rank : 22)
Query Neighborhood Hits	61	Target Neighborhood Hits	215	Shared Neighborhood Hits	3
SwissProt Accessions	P53996, Q80Y06, Q8BP23	Gene names	Cnbp, Cnbp1, Znf9
Domain Architecture	No domain graphic available
Description	Cellular nucleic acid-binding protein (CNBP) (Zinc finger protein 9).

KRA58_HUMAN
NC score	0.045648 (rank : 28)	θ value	2.36792 (rank : 39)
Query Neighborhood Hits	61	Target Neighborhood Hits	324	Shared Neighborhood Hits	28
SwissProt Accessions	O75690, Q6L8G7, Q6UTX6	Gene names	KRTAP5-8, KAP5.8, KRTAP5.8, UHSKB
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-8 (Keratin-associated protein 5.8) (Ultrahigh sulfur keratin-associated protein 5.8) (Keratin, ultra high-sulfur matrix protein B) (UHS keratin B) (UHS KerB).

LTBP2_MOUSE
NC score	0.042109 (rank : 29)	θ value	0.163984 (rank : 23)
Query Neighborhood Hits	61	Target Neighborhood Hits	617	Shared Neighborhood Hits	29
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

GRN_HUMAN
NC score	0.040245 (rank : 30)	θ value	4.03905 (rank : 46)
Query Neighborhood Hits	61	Target Neighborhood Hits	268	Shared Neighborhood Hits	29
SwissProt Accessions	P28799, P23781, P23782, P23783, P23784, Q9BWE7, Q9UCH0	Gene names	GRN
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin; Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)].

FBN2_HUMAN
NC score	0.039617 (rank : 31)	θ value	0.21417 (rank : 24)
Query Neighborhood Hits	61	Target Neighborhood Hits	560	Shared Neighborhood Hits	30
SwissProt Accessions	P35556	Gene names	FBN2
Domain Architecture
Description	Fibrillin-2 precursor.

ARSA_MOUSE
NC score	0.039403 (rank : 32)	θ value	0.813845 (rank : 31)
Query Neighborhood Hits	61	Target Neighborhood Hits	30	Shared Neighborhood Hits	6
SwissProt Accessions	P50428	Gene names	Arsa, As2
Domain Architecture
Description	Arylsulfatase A precursor (EC 3.1.6.8) (ASA) (Cerebroside-sulfatase).

FBN2_MOUSE
NC score	0.036746 (rank : 33)	θ value	1.38821 (rank : 35)
Query Neighborhood Hits	61	Target Neighborhood Hits	549	Shared Neighborhood Hits	31
SwissProt Accessions	Q61555, Q63957	Gene names	Fbn2, Fbn-2
Domain Architecture
Description	Fibrillin-2 precursor.

FBN1_HUMAN
NC score	0.036036 (rank : 34)	θ value	3.0926 (rank : 41)
Query Neighborhood Hits	61	Target Neighborhood Hits	557	Shared Neighborhood Hits	31
SwissProt Accessions	P35555, Q15972, Q75N87	Gene names	FBN1, FBN
Domain Architecture
Description	Fibrillin-1 precursor.

FBN1_MOUSE
NC score	0.034509 (rank : 35)	θ value	4.03905 (rank : 45)
Query Neighborhood Hits	61	Target Neighborhood Hits	563	Shared Neighborhood Hits	30
SwissProt Accessions	Q61554, Q60826	Gene names	Fbn1, Fbn-1
Domain Architecture
Description	Fibrillin-1 precursor.

LRP1B_HUMAN
NC score	0.033763 (rank : 36)	θ value	0.62314 (rank : 28)
Query Neighborhood Hits	61	Target Neighborhood Hits	602	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

TECTA_MOUSE
NC score	0.032264 (rank : 37)	θ value	0.365318 (rank : 26)
Query Neighborhood Hits	61	Target Neighborhood Hits	244	Shared Neighborhood Hits	27
SwissProt Accessions	O08523	Gene names	Tecta
Domain Architecture
Description	Alpha-tectorin precursor.

MEGF6_HUMAN
NC score	0.031965 (rank : 38)	θ value	0.813845 (rank : 32)
Query Neighborhood Hits	61	Target Neighborhood Hits	671	Shared Neighborhood Hits	30
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

LRP2_HUMAN
NC score	0.031911 (rank : 39)	θ value	4.03905 (rank : 47)
Query Neighborhood Hits	61	Target Neighborhood Hits	573	Shared Neighborhood Hits	33
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

SCUB3_MOUSE
NC score	0.031382 (rank : 40)	θ value	1.81305 (rank : 37)
Query Neighborhood Hits	61	Target Neighborhood Hits	442	Shared Neighborhood Hits	26
SwissProt Accessions	Q66PY1, Q68FG9	Gene names	Scube3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

FSTL5_HUMAN
NC score	0.030889 (rank : 41)	θ value	0.279714 (rank : 25)
Query Neighborhood Hits	61	Target Neighborhood Hits	347	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

WFDC8_HUMAN
NC score	0.030421 (rank : 42)	θ value	3.0926 (rank : 42)
Query Neighborhood Hits	61	Target Neighborhood Hits	82	Shared Neighborhood Hits	10
SwissProt Accessions	Q8IUA0, Q5TDV2, Q96A34	Gene names	WFDC8, C20orf170, WAP8
Domain Architecture
Description	WAP four-disulfide core domain protein 8 precursor (Putative protease inhibitor WAP8).

NOTC4_MOUSE
NC score	0.030344 (rank : 43)	θ value	0.47712 (rank : 27)
Query Neighborhood Hits	61	Target Neighborhood Hits	872	Shared Neighborhood Hits	33
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

ARSF_HUMAN
NC score	0.029185 (rank : 44)	θ value	2.36792 (rank : 38)
Query Neighborhood Hits	61	Target Neighborhood Hits	33	Shared Neighborhood Hits	8
SwissProt Accessions	P54793, Q8TCC5	Gene names	ARSF
Domain Architecture
Description	Arylsulfatase F precursor (EC 3.1.6.-) (ASF).

LRP1B_MOUSE
NC score	0.028572 (rank : 45)	θ value	6.88961 (rank : 54)
Query Neighborhood Hits	61	Target Neighborhood Hits	606	Shared Neighborhood Hits	34
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

SCUB3_HUMAN
NC score	0.028397 (rank : 46)	θ value	6.88961 (rank : 56)
Query Neighborhood Hits	61	Target Neighborhood Hits	428	Shared Neighborhood Hits	25
SwissProt Accessions	Q8IX30, Q5CZB3, Q86UZ9, Q8NAU9	Gene names	SCUBE3, CEGF3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

STS_MOUSE
NC score	0.027605 (rank : 47)	θ value	8.99809 (rank : 61)
Query Neighborhood Hits	61	Target Neighborhood Hits	38	Shared Neighborhood Hits	8
SwissProt Accessions	P50427	Gene names	Sts
Domain Architecture
Description	Steryl-sulfatase precursor (EC 3.1.6.2) (Steroid sulfatase) (Steryl- sulfate sulfohydrolase) (Arylsulfatase C) (ASC).

FSTL4_HUMAN
NC score	0.027427 (rank : 48)	θ value	1.06291 (rank : 33)
Query Neighborhood Hits	61	Target Neighborhood Hits	344	Shared Neighborhood Hits	12
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

NOTC2_MOUSE
NC score	0.026899 (rank : 49)	θ value	5.27518 (rank : 49)
Query Neighborhood Hits	61	Target Neighborhood Hits	1069	Shared Neighborhood Hits	36
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

FSTL4_MOUSE
NC score	0.026363 (rank : 50)	θ value	1.38821 (rank : 36)
Query Neighborhood Hits	61	Target Neighborhood Hits	333	Shared Neighborhood Hits	9
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

LRP1_HUMAN
NC score	0.026073 (rank : 51)	θ value	6.88961 (rank : 55)
Query Neighborhood Hits	61	Target Neighborhood Hits	617	Shared Neighborhood Hits	31
SwissProt Accessions	Q07954, Q2PP12, Q8IVG8	Gene names	LRP1, A2MR
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1 precursor (LRP) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD91 antigen).

NOTC4_HUMAN
NC score	0.024685 (rank : 52)	θ value	5.27518 (rank : 50)
Query Neighborhood Hits	61	Target Neighborhood Hits	905	Shared Neighborhood Hits	31
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

NOTC1_MOUSE
NC score	0.024423 (rank : 53)	θ value	8.99809 (rank : 60)
Query Neighborhood Hits	61	Target Neighborhood Hits	916	Shared Neighborhood Hits	31
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

NOTC1_HUMAN
NC score	0.024200 (rank : 54)	θ value	5.27518 (rank : 48)
Query Neighborhood Hits	61	Target Neighborhood Hits	906	Shared Neighborhood Hits	33
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

ADA28_HUMAN
NC score	0.024121 (rank : 55)	θ value	0.163984 (rank : 21)
Query Neighborhood Hits	61	Target Neighborhood Hits	244	Shared Neighborhood Hits	23
SwissProt Accessions	Q9UKQ2, Q9Y339, Q9Y3S0	Gene names	ADAM28, MDCL
Domain Architecture
Description	ADAM 28 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 28) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein-L) (MDC-L) (eMDC II) (ADAM23).

AGRIN_HUMAN
NC score	0.023005 (rank : 56)	θ value	6.88961 (rank : 53)
Query Neighborhood Hits	61	Target Neighborhood Hits	582	Shared Neighborhood Hits	32
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

CASC5_MOUSE
NC score	0.021983 (rank : 57)	θ value	1.38821 (rank : 34)
Query Neighborhood Hits	61	Target Neighborhood Hits	70	Shared Neighborhood Hits	2
SwissProt Accessions	Q66JQ7, Q8CCH6, Q9CV38	Gene names	Casc5
Domain Architecture	No domain graphic available
Description	Protein CASC5 (Cancer susceptibility candidate gene 5 protein homolog).

KRA45_HUMAN
NC score	0.018396 (rank : 58)	θ value	8.99809 (rank : 57)
Query Neighborhood Hits	61	Target Neighborhood Hits	194	Shared Neighborhood Hits	22
SwissProt Accessions	Q9BYR2	Gene names	KRTAP4-5, KAP4.5, KRTAP4.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-5 (Keratin-associated protein 4.5) (Ultrahigh sulfur keratin-associated protein 4.5).

KRA52_HUMAN
NC score	0.018186 (rank : 59)	θ value	8.99809 (rank : 58)
Query Neighborhood Hits	61	Target Neighborhood Hits	236	Shared Neighborhood Hits	23
SwissProt Accessions	Q701N4	Gene names	KRTAP5-2, KAP5-8, KAP5.2, KRTAP5-8, KRTAP5.2, KRTAP5.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-2 (Keratin-associated protein 5.2) (Ultrahigh sulfur keratin-associated protein 5.2) (Keratin-associated protein 5-8) (Keratin-associated protein 5.8).

ADAM2_HUMAN
NC score	0.014597 (rank : 60)	θ value	4.03905 (rank : 44)
Query Neighborhood Hits	61	Target Neighborhood Hits	175	Shared Neighborhood Hits	21
SwissProt Accessions	Q99965, P78326, Q9UQQ8	Gene names	ADAM2, FTNB
Domain Architecture
Description	ADAM 2 precursor (A disintegrin and metalloproteinase domain 2) (Fertilin subunit beta) (PH-30) (PH30).

ADA28_MOUSE
NC score	0.014548 (rank : 61)	θ value	4.03905 (rank : 43)
Query Neighborhood Hits	61	Target Neighborhood Hits	241	Shared Neighborhood Hits	24
SwissProt Accessions	Q9JLN6, Q8K5D2, Q8K5D3	Gene names	Adam28
Domain Architecture
Description	ADAM 28 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 28) (Thymic epithelial cell-ADAM) (TECADAM).

MT1X_HUMAN
NC score	0.009487 (rank : 62)	θ value	8.99809 (rank : 59)
Query Neighborhood Hits	61	Target Neighborhood Hits	76	Shared Neighborhood Hits	4
SwissProt Accessions	P80297	Gene names	MT1X
Domain Architecture	No domain graphic available
Description	Metallothionein-1X (MT-1X) (Metallothionein-IX) (MT-IX).

ABTB2_HUMAN
NC score	0.007809 (rank : 63)	θ value	6.88961 (rank : 51)
Query Neighborhood Hits	61	Target Neighborhood Hits	391	Shared Neighborhood Hits	8
SwissProt Accessions	Q8N961, Q6MZW4, Q8NB44	Gene names	ABTB2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

ABTB2_MOUSE
NC score	0.007639 (rank : 64)	θ value	6.88961 (rank : 52)
Query Neighborhood Hits	61	Target Neighborhood Hits	414	Shared Neighborhood Hits	7
SwissProt Accessions	Q7TQI7	Gene names	Abtb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.