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Network neighborhood for query Sequence : TINAG_HUMAN

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TINAG_HUMAN
SwissProt Accessions	Q9UJW2, Q9UJW1, Q9ULZ4	Gene names	TINAG
Domain Architecture
Description	Tubulointerstitial nephritis antigen (TIN-Ag).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TINAG_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	63	Target Neighborhood Hits	63	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UJW2, Q9UJW1, Q9ULZ4	Gene names	TINAG
Domain Architecture
Description	Tubulointerstitial nephritis antigen (TIN-Ag).

TINAL_HUMAN
θ value	1.0968e-122 (rank : 2)	NC score	0.973221 (rank : 2)
Query Neighborhood Hits	63	Target Neighborhood Hits	50	Shared Neighborhood Hits	37
SwissProt Accessions	Q9GZM7, Q8TEJ9, Q8WZ23, Q96GZ4, Q96JW3	Gene names	TINAGL1, GIS5, LCN7, OLRG2, TINAGL
Domain Architecture	No domain graphic available
Description	Tubulointerstitial nephritis antigen-like precursor (Tubulointerstitial nephritis antigen-related protein) (TIN Ag-related protein) (TIN-Ag-RP) (Glucocorticoid-inducible protein 5) (Oxidized LDL-responsive gene 2 protein) (OLRG-2).

TINAL_MOUSE
θ value	9.28496e-122 (rank : 3)	NC score	0.971293 (rank : 3)
Query Neighborhood Hits	63	Target Neighborhood Hits	52	Shared Neighborhood Hits	39
SwissProt Accessions	Q99JR5, Q9EQT9	Gene names	Tinagl1, Arg1, Lcn7, Tinagl
Domain Architecture	No domain graphic available
Description	Tubulointerstitial nephritis antigen-like precursor (Androgen- regulated gene 1 protein) (Adrenocortical zonation factor 1) (AZ-1) (Tubulointerstitial nephritis antigen-related protein) (TARP).

CATB_MOUSE
θ value	1.6247e-33 (rank : 4)	NC score	0.878775 (rank : 4)
Query Neighborhood Hits	63	Target Neighborhood Hits	30	Shared Neighborhood Hits	27
SwissProt Accessions	P10605, Q3UDW7	Gene names	Ctsb
Domain Architecture
Description	Cathepsin B precursor (EC 3.4.22.1) (Cathepsin B1) [Contains: Cathepsin B light chain; Cathepsin B heavy chain].

CATB_HUMAN
θ value	3.06405e-32 (rank : 5)	NC score	0.875935 (rank : 5)
Query Neighborhood Hits	63	Target Neighborhood Hits	38	Shared Neighborhood Hits	27
SwissProt Accessions	P07858, Q96D87	Gene names	CTSB, CPSB
Domain Architecture
Description	Cathepsin B precursor (EC 3.4.22.1) (Cathepsin B1) (APP secretase) (APPS) [Contains: Cathepsin B light chain; Cathepsin B heavy chain].

CATC_MOUSE
θ value	3.74554e-30 (rank : 6)	NC score	0.844610 (rank : 6)
Query Neighborhood Hits	63	Target Neighborhood Hits	30	Shared Neighborhood Hits	27
SwissProt Accessions	P97821, O08853	Gene names	Ctsc
Domain Architecture
Description	Dipeptidyl-peptidase 1 precursor (EC 3.4.14.1) (Dipeptidyl-peptidase I) (DPP-I) (DPPI) (Cathepsin C) (Cathepsin J) (Dipeptidyl transferase) [Contains: Dipeptidyl-peptidase 1 exclusion domain chain (Dipeptidyl- peptidase I exclusion domain chain); Dipeptidyl-peptidase 1 heavy chain (Dipeptidyl-peptidase I heavy chain); Dipeptidyl-peptidase 1 light chain (Dipeptidyl-peptidase I light chain)].

CATC_HUMAN
θ value	4.14116e-29 (rank : 7)	NC score	0.842168 (rank : 7)
Query Neighborhood Hits	63	Target Neighborhood Hits	28	Shared Neighborhood Hits	27
SwissProt Accessions	P53634, Q8WYA7, Q8WYA8	Gene names	CTSC, CPPI
Domain Architecture
Description	Dipeptidyl-peptidase 1 precursor (EC 3.4.14.1) (Dipeptidyl-peptidase I) (DPP-I) (DPPI) (Cathepsin C) (Cathepsin J) (Dipeptidyl transferase) [Contains: Dipeptidyl-peptidase 1 exclusion domain chain (Dipeptidyl- peptidase I exclusion domain chain); Dipeptidyl-peptidase 1 heavy chain (Dipeptidyl-peptidase I heavy chain); Dipeptidyl-peptidase 1 light chain (Dipeptidyl-peptidase I light chain)].

CATL2_HUMAN
θ value	2.7842e-17 (rank : 8)	NC score	0.736073 (rank : 17)
Query Neighborhood Hits	63	Target Neighborhood Hits	34	Shared Neighborhood Hits	27
SwissProt Accessions	O60911, O60233, Q5T1U0	Gene names	CTSL2, CATL2, CTSU, CTSV
Domain Architecture
Description	Cathepsin L2 precursor (EC 3.4.22.43) (Cathepsin V) (Cathepsin U).

CATH_MOUSE
θ value	3.63628e-17 (rank : 9)	NC score	0.774236 (rank : 10)
Query Neighborhood Hits	63	Target Neighborhood Hits	28	Shared Neighborhood Hits	27
SwissProt Accessions	P49935	Gene names	Ctsh
Domain Architecture
Description	Cathepsin H precursor (EC 3.4.22.16) (Cathepsin B3) (Cathepsin BA) [Contains: Cathepsin H mini chain; Cathepsin H heavy chain; Cathepsin H light chain].

CATZ_HUMAN
θ value	1.38178e-16 (rank : 10)	NC score	0.792868 (rank : 8)
Query Neighborhood Hits	63	Target Neighborhood Hits	29	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UBR2, O75331, Q9UQV5, Q9UQV6	Gene names	CTSZ
Domain Architecture
Description	Cathepsin Z precursor (EC 3.4.22.-) (Cathepsin X) (Cathepsin P).

CATK_HUMAN
θ value	8.95645e-16 (rank : 11)	NC score	0.737689 (rank : 16)
Query Neighborhood Hits	63	Target Neighborhood Hits	34	Shared Neighborhood Hits	27
SwissProt Accessions	P43235	Gene names	CTSK, CTSO, CTSO2
Domain Architecture
Description	Cathepsin K precursor (EC 3.4.22.38) (Cathepsin O) (Cathepsin X) (Cathepsin O2).

CATK_MOUSE
θ value	1.99529e-15 (rank : 12)	NC score	0.742070 (rank : 14)
Query Neighborhood Hits	63	Target Neighborhood Hits	36	Shared Neighborhood Hits	27
SwissProt Accessions	P55097, O88718	Gene names	Ctsk
Domain Architecture
Description	Cathepsin K precursor (EC 3.4.22.38).

CATH_HUMAN
θ value	2.60593e-15 (rank : 13)	NC score	0.768306 (rank : 11)
Query Neighborhood Hits	63	Target Neighborhood Hits	29	Shared Neighborhood Hits	27
SwissProt Accessions	P09668, Q9BUM7	Gene names	CTSH
Domain Architecture
Description	Cathepsin H precursor (EC 3.4.22.16) [Contains: Cathepsin H mini chain; Cathepsin H heavy chain; Cathepsin H light chain].

CATZ_MOUSE
θ value	5.8054e-15 (rank : 14)	NC score	0.788863 (rank : 9)
Query Neighborhood Hits	63	Target Neighborhood Hits	29	Shared Neighborhood Hits	27
SwissProt Accessions	Q9WUU7	Gene names	Ctsz
Domain Architecture
Description	Cathepsin Z precursor (EC 3.4.22.-).

CATS_HUMAN
θ value	1.29331e-14 (rank : 15)	NC score	0.749996 (rank : 12)
Query Neighborhood Hits	63	Target Neighborhood Hits	31	Shared Neighborhood Hits	27
SwissProt Accessions	P25774, Q5T5I0, Q9BUG3	Gene names	CTSS
Domain Architecture
Description	Cathepsin S precursor (EC 3.4.22.27).

CATL_MOUSE
θ value	2.20605e-14 (rank : 16)	NC score	0.728169 (rank : 22)
Query Neighborhood Hits	63	Target Neighborhood Hits	29	Shared Neighborhood Hits	27
SwissProt Accessions	P06797, Q91UZ0	Gene names	Ctsl
Domain Architecture
Description	Cathepsin L precursor (EC 3.4.22.15) (Major excreted protein) (MEP) (p39 cysteine proteinase) [Contains: Cathepsin L heavy chain; Cathepsin L light chain].

CATS_MOUSE
θ value	8.38298e-14 (rank : 17)	NC score	0.742731 (rank : 13)
Query Neighborhood Hits	63	Target Neighborhood Hits	28	Shared Neighborhood Hits	27
SwissProt Accessions	O70370, O54973	Gene names	Ctss, Cats
Domain Architecture
Description	Cathepsin S precursor (EC 3.4.22.27).

CATL_HUMAN
θ value	1.09485e-13 (rank : 18)	NC score	0.729423 (rank : 20)
Query Neighborhood Hits	63	Target Neighborhood Hits	32	Shared Neighborhood Hits	27
SwissProt Accessions	P07711, Q96QJ0	Gene names	CTSL
Domain Architecture
Description	Cathepsin L precursor (EC 3.4.22.15) (Major excreted protein) (MEP) [Contains: Cathepsin L heavy chain; Cathepsin L light chain].

CATJ_MOUSE
θ value	2.43908e-13 (rank : 19)	NC score	0.733328 (rank : 18)
Query Neighborhood Hits	63	Target Neighborhood Hits	32	Shared Neighborhood Hits	27
SwissProt Accessions	Q9R014, Q564D9, Q91XK6, Q9WV51	Gene names	Ctsj, Ctsp
Domain Architecture
Description	Cathepsin J precursor (EC 3.4.22.-) (Cathepsin P) (Cathepsin L-related protein) (Catlrp-p).

CATR_MOUSE
θ value	2.43908e-13 (rank : 20)	NC score	0.728183 (rank : 21)
Query Neighborhood Hits	63	Target Neighborhood Hits	31	Shared Neighborhood Hits	27
SwissProt Accessions	Q9JIA9	Gene names	Ctsr, Catr
Domain Architecture
Description	Cathepsin R precursor (EC 3.4.22.-).

CATO_HUMAN
θ value	3.52202e-12 (rank : 21)	NC score	0.739146 (rank : 15)
Query Neighborhood Hits	63	Target Neighborhood Hits	30	Shared Neighborhood Hits	27
SwissProt Accessions	P43234	Gene names	CTSO, CTSO1
Domain Architecture
Description	Cathepsin O precursor (EC 3.4.22.42).

CATM_MOUSE
θ value	4.59992e-12 (rank : 22)	NC score	0.706065 (rank : 25)
Query Neighborhood Hits	63	Target Neighborhood Hits	30	Shared Neighborhood Hits	27
SwissProt Accessions	Q9JL96, Q91Z75, Q91ZF3, Q9CQB9	Gene names	Ctsm, Catm
Domain Architecture
Description	Cathepsin M precursor (EC 3.4.22.-).

CATW_HUMAN
θ value	1.9326e-10 (rank : 23)	NC score	0.714725 (rank : 24)
Query Neighborhood Hits	63	Target Neighborhood Hits	29	Shared Neighborhood Hits	27
SwissProt Accessions	P56202, Q86VT4	Gene names	CTSW
Domain Architecture
Description	Cathepsin W precursor (EC 3.4.22.-) (Lymphopain).

CATW_MOUSE
θ value	7.34386e-10 (rank : 24)	NC score	0.720919 (rank : 23)
Query Neighborhood Hits	63	Target Neighborhood Hits	30	Shared Neighborhood Hits	29
SwissProt Accessions	P56203	Gene names	Ctsw
Domain Architecture
Description	Cathepsin W precursor (EC 3.4.22.-) (Lymphopain).

CATO_MOUSE
θ value	2.13673e-09 (rank : 25)	NC score	0.730641 (rank : 19)
Query Neighborhood Hits	63	Target Neighborhood Hits	29	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BM88, Q3TM69, Q80V35, Q8BKX0	Gene names	Ctso
Domain Architecture	No domain graphic available
Description	Cathepsin O precursor (EC 3.4.22.42).

CATF_HUMAN
θ value	4.92598e-06 (rank : 26)	NC score	0.686294 (rank : 26)
Query Neighborhood Hits	63	Target Neighborhood Hits	37	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UBX1, O95240, Q9NSU4, Q9UKQ5	Gene names	CTSF
Domain Architecture
Description	Cathepsin F precursor (EC 3.4.22.41) (CATSF).

VWF_HUMAN
θ value	2.44474e-05 (rank : 27)	NC score	0.152034 (rank : 30)
Query Neighborhood Hits	63	Target Neighborhood Hits	396	Shared Neighborhood Hits	28
SwissProt Accessions	P04275	Gene names	VWF, F8VWF
Domain Architecture
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

VWF_MOUSE
θ value	5.44631e-05 (rank : 28)	NC score	0.149922 (rank : 31)
Query Neighborhood Hits	63	Target Neighborhood Hits	381	Shared Neighborhood Hits	27
SwissProt Accessions	Q8CIZ8, Q60863, Q6XUV6, Q8BIU9, Q8CGN0, Q9JK16	Gene names	Vwf
Domain Architecture	No domain graphic available
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

CATF_MOUSE
θ value	0.000121331 (rank : 29)	NC score	0.683766 (rank : 27)
Query Neighborhood Hits	63	Target Neighborhood Hits	30	Shared Neighborhood Hits	27
SwissProt Accessions	Q9R013, Q9WUT4	Gene names	Ctsf
Domain Architecture
Description	Cathepsin F precursor (EC 3.4.22.41).

SSPO_MOUSE
θ value	0.000461057 (rank : 30)	NC score	0.106195 (rank : 35)
Query Neighborhood Hits	63	Target Neighborhood Hits	800	Shared Neighborhood Hits	31
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

MUC2_HUMAN
θ value	0.000602161 (rank : 31)	NC score	0.118883 (rank : 34)
Query Neighborhood Hits	63	Target Neighborhood Hits	906	Shared Neighborhood Hits	28
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

MUC5B_HUMAN
θ value	0.000602161 (rank : 32)	NC score	0.136786 (rank : 32)
Query Neighborhood Hits	63	Target Neighborhood Hits	1020	Shared Neighborhood Hits	30
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

ENPP3_HUMAN
θ value	0.00134147 (rank : 33)	NC score	0.094474 (rank : 37)
Query Neighborhood Hits	63	Target Neighborhood Hits	34	Shared Neighborhood Hits	9
SwissProt Accessions	O14638	Gene names	ENPP3, PDNP3
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 3 (E-NPP 3) (Phosphodiesterase I/nucleotide pyrophosphatase 3) (Phosphodiesterase I beta) (PD-Ibeta) (CD203c antigen) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP1_HUMAN
θ value	0.0330416 (rank : 34)	NC score	0.087795 (rank : 38)
Query Neighborhood Hits	63	Target Neighborhood Hits	47	Shared Neighborhood Hits	11
SwissProt Accessions	P22413, Q5T9R6, Q9NPZ3, Q9P1P6, Q9UP61, Q9Y6K3	Gene names	ENPP1, NPPS, PC1, PDNP1
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP1_MOUSE
θ value	0.0563607 (rank : 35)	NC score	0.086801 (rank : 39)
Query Neighborhood Hits	63	Target Neighborhood Hits	65	Shared Neighborhood Hits	9
SwissProt Accessions	P06802	Gene names	Enpp1, Npps, Pc1, Pdnp1
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) (Antigen Ly-41) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

FSTL1_MOUSE
θ value	0.125558 (rank : 36)	NC score	0.071069 (rank : 44)
Query Neighborhood Hits	63	Target Neighborhood Hits	74	Shared Neighborhood Hits	10
SwissProt Accessions	Q62356, Q99JI9	Gene names	Fstl1, Frp, Fstl, Tsc36
Domain Architecture
Description	Follistatin-related protein 1 precursor (Follistatin-like 1) (TGF- beta-inducible protein TSC-36).

PRG4_HUMAN
θ value	0.125558 (rank : 37)	NC score	0.049948 (rank : 49)
Query Neighborhood Hits	63	Target Neighborhood Hits	764	Shared Neighborhood Hits	13
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

FSTL1_HUMAN
θ value	0.21417 (rank : 38)	NC score	0.070387 (rank : 46)
Query Neighborhood Hits	63	Target Neighborhood Hits	68	Shared Neighborhood Hits	10
SwissProt Accessions	Q12841	Gene names	FSTL1, FRP
Domain Architecture
Description	Follistatin-related protein 1 precursor (Follistatin-like 1).

BMPER_HUMAN
θ value	0.47712 (rank : 39)	NC score	0.119727 (rank : 33)
Query Neighborhood Hits	63	Target Neighborhood Hits	175	Shared Neighborhood Hits	23
SwissProt Accessions	Q8N8U9	Gene names	BMPER
Domain Architecture
Description	BMP-binding endothelial regulator protein precursor (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (hCV2).

ENPP2_MOUSE
θ value	0.47712 (rank : 40)	NC score	0.083087 (rank : 40)
Query Neighborhood Hits	63	Target Neighborhood Hits	66	Shared Neighborhood Hits	13
SwissProt Accessions	Q9R1E6, Q99LG9	Gene names	Enpp2, Npps2
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2) (Phosphodiesterase I/nucleotide pyrophosphatase 2) (Phosphodiesterase I alpha) (PD-Ialpha) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

FA10_MOUSE
θ value	0.47712 (rank : 41)	NC score	0.011274 (rank : 68)
Query Neighborhood Hits	63	Target Neighborhood Hits	435	Shared Neighborhood Hits	15
SwissProt Accessions	O88947, O54740, Q99L32	Gene names	F10
Domain Architecture
Description	Coagulation factor X precursor (EC 3.4.21.6) (Stuart factor) [Contains: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain].

PRG4_MOUSE
θ value	0.47712 (rank : 42)	NC score	0.038449 (rank : 53)
Query Neighborhood Hits	63	Target Neighborhood Hits	624	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

ENPP2_HUMAN
θ value	0.62314 (rank : 43)	NC score	0.080230 (rank : 41)
Query Neighborhood Hits	63	Target Neighborhood Hits	61	Shared Neighborhood Hits	14
SwissProt Accessions	Q13822, Q13827, Q15117	Gene names	ENPP2, ATX, PDNP2
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2) (Phosphodiesterase I/nucleotide pyrophosphatase 2) (Phosphodiesterase I alpha) (PD-Ialpha) (Autotaxin) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

LRP1B_HUMAN
θ value	0.813845 (rank : 44)	NC score	0.034774 (rank : 55)
Query Neighborhood Hits	63	Target Neighborhood Hits	602	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

LRP1B_MOUSE
θ value	0.813845 (rank : 45)	NC score	0.034457 (rank : 56)
Query Neighborhood Hits	63	Target Neighborhood Hits	606	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

WISP1_HUMAN
θ value	0.813845 (rank : 46)	NC score	0.037351 (rank : 54)
Query Neighborhood Hits	63	Target Neighborhood Hits	121	Shared Neighborhood Hits	17
SwissProt Accessions	O95388, Q9HCS3	Gene names	WISP1, CCN4
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (Wnt-1- induced secreted protein).

BMPER_MOUSE
θ value	1.06291 (rank : 47)	NC score	0.104057 (rank : 36)
Query Neighborhood Hits	63	Target Neighborhood Hits	194	Shared Neighborhood Hits	27
SwissProt Accessions	Q8CJ69, Q7TN57, Q80UZ1, Q9CXM8	Gene names	Bmper, Cv2
Domain Architecture
Description	BMP-binding endothelial regulator protein precursor (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (mCV2).

JAG2_MOUSE
θ value	1.06291 (rank : 48)	NC score	0.028694 (rank : 62)
Query Neighborhood Hits	63	Target Neighborhood Hits	504	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QYE5, O55139, O70219	Gene names	Jag2
Domain Architecture
Description	Jagged-2 precursor (Jagged2).

JAG2_HUMAN
θ value	1.38821 (rank : 49)	NC score	0.026497 (rank : 63)
Query Neighborhood Hits	63	Target Neighborhood Hits	491	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y219, Q9UE17, Q9UE99, Q9UNK8, Q9Y6P9, Q9Y6Q0	Gene names	JAG2
Domain Architecture
Description	Jagged-2 precursor (Jagged2) (HJ2).

NOTC1_HUMAN
θ value	1.38821 (rank : 50)	NC score	0.022217 (rank : 66)
Query Neighborhood Hits	63	Target Neighborhood Hits	906	Shared Neighborhood Hits	27
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

VLDLR_HUMAN
θ value	1.38821 (rank : 51)	NC score	0.031999 (rank : 59)
Query Neighborhood Hits	63	Target Neighborhood Hits	383	Shared Neighborhood Hits	21
SwissProt Accessions	P98155, Q5VVF6	Gene names	VLDLR
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

FRAS1_HUMAN
θ value	1.81305 (rank : 52)	NC score	0.042381 (rank : 52)
Query Neighborhood Hits	63	Target Neighborhood Hits	759	Shared Neighborhood Hits	27
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

GALM_HUMAN
θ value	1.81305 (rank : 53)	NC score	0.025779 (rank : 64)
Query Neighborhood Hits	63	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	Q96C23, Q8NIA2	Gene names	GALM
Domain Architecture	No domain graphic available
Description	Aldose 1-epimerase (EC 5.1.3.3) (Galactose mutarotase) (BLOCK25 protein).

FRAS1_MOUSE
θ value	2.36792 (rank : 54)	NC score	0.042515 (rank : 51)
Query Neighborhood Hits	63	Target Neighborhood Hits	747	Shared Neighborhood Hits	26
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

ZAN_MOUSE
θ value	3.0926 (rank : 55)	NC score	0.069237 (rank : 48)
Query Neighborhood Hits	63	Target Neighborhood Hits	808	Shared Neighborhood Hits	30
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

TSP2_HUMAN
θ value	4.03905 (rank : 56)	NC score	0.020224 (rank : 67)
Query Neighborhood Hits	63	Target Neighborhood Hits	359	Shared Neighborhood Hits	21
SwissProt Accessions	P35442	Gene names	THBS2, TSP2
Domain Architecture
Description	Thrombospondin-2 precursor.

VLDLR_MOUSE
θ value	4.03905 (rank : 57)	NC score	0.030037 (rank : 61)
Query Neighborhood Hits	63	Target Neighborhood Hits	360	Shared Neighborhood Hits	20
SwissProt Accessions	P98156, Q64022	Gene names	Vldlr
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

LRP1_HUMAN
θ value	5.27518 (rank : 58)	NC score	0.031503 (rank : 60)
Query Neighborhood Hits	63	Target Neighborhood Hits	617	Shared Neighborhood Hits	27
SwissProt Accessions	Q07954, Q2PP12, Q8IVG8	Gene names	LRP1, A2MR
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1 precursor (LRP) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD91 antigen).

WISP1_MOUSE
θ value	5.27518 (rank : 59)	NC score	0.032812 (rank : 58)
Query Neighborhood Hits	63	Target Neighborhood Hits	123	Shared Neighborhood Hits	15
SwissProt Accessions	O54775, Q80ZL1	Gene names	Wisp1, Ccn4, Elm1
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (ELM-1).

FA10_HUMAN
θ value	6.88961 (rank : 60)	NC score	0.008146 (rank : 69)
Query Neighborhood Hits	63	Target Neighborhood Hits	431	Shared Neighborhood Hits	15
SwissProt Accessions	P00742, Q14340	Gene names	F10
Domain Architecture
Description	Coagulation factor X precursor (EC 3.4.21.6) (Stuart factor) (Stuart- Prower factor) [Contains: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain].

LRP2_HUMAN
θ value	6.88961 (rank : 61)	NC score	0.032980 (rank : 57)
Query Neighborhood Hits	63	Target Neighborhood Hits	573	Shared Neighborhood Hits	28
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

NOTC1_MOUSE
θ value	8.99809 (rank : 62)	NC score	0.025400 (rank : 65)
Query Neighborhood Hits	63	Target Neighborhood Hits	916	Shared Neighborhood Hits	29
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

RECK_HUMAN
θ value	8.99809 (rank : 63)	NC score	0.046136 (rank : 50)
Query Neighborhood Hits	63	Target Neighborhood Hits	189	Shared Neighborhood Hits	26
SwissProt Accessions	O95980, Q8WX37	Gene names	RECK
Domain Architecture
Description	Reversion-inducing cysteine-rich protein with Kazal motifs precursor (hRECK) (Suppressor of tumorigenicity 15) (ST15).

CRIM1_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.069616 (rank : 47)
Query Neighborhood Hits	63	Target Neighborhood Hits	362	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

CTL2A_MOUSE
θ value	θ > 10 (rank : 65)	NC score	0.381962 (rank : 28)
Query Neighborhood Hits	63	Target Neighborhood Hits	20	Shared Neighborhood Hits	16
SwissProt Accessions	P12399	Gene names	Ctla2a
Domain Architecture	No domain graphic available
Description	CTLA-2-alpha protein precursor.

TECTA_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.072885 (rank : 43)
Query Neighborhood Hits	63	Target Neighborhood Hits	239	Shared Neighborhood Hits	23
SwissProt Accessions	O75443	Gene names	TECTA
Domain Architecture
Description	Alpha-tectorin precursor.

TECTA_MOUSE
θ value	θ > 10 (rank : 67)	NC score	0.073256 (rank : 42)
Query Neighborhood Hits	63	Target Neighborhood Hits	244	Shared Neighborhood Hits	27
SwissProt Accessions	O08523	Gene names	Tecta
Domain Architecture
Description	Alpha-tectorin precursor.

TSP_MOUSE
θ value	θ > 10 (rank : 68)	NC score	0.241145 (rank : 29)
Query Neighborhood Hits	63	Target Neighborhood Hits	15	Shared Neighborhood Hits	9
SwissProt Accessions	P13438	Gene names	Tpbpa, Tpbp
Domain Architecture	No domain graphic available
Description	Trophoblast-specific protein alpha precursor.

ZAN_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.070824 (rank : 45)
Query Neighborhood Hits	63	Target Neighborhood Hits	679	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

Hits sorted by NC score

TINAG_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	63	Target Neighborhood Hits	63	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UJW2, Q9UJW1, Q9ULZ4	Gene names	TINAG
Domain Architecture
Description	Tubulointerstitial nephritis antigen (TIN-Ag).

TINAL_HUMAN
NC score	0.973221 (rank : 2)	θ value	1.0968e-122 (rank : 2)
Query Neighborhood Hits	63	Target Neighborhood Hits	50	Shared Neighborhood Hits	37
SwissProt Accessions	Q9GZM7, Q8TEJ9, Q8WZ23, Q96GZ4, Q96JW3	Gene names	TINAGL1, GIS5, LCN7, OLRG2, TINAGL
Domain Architecture	No domain graphic available
Description	Tubulointerstitial nephritis antigen-like precursor (Tubulointerstitial nephritis antigen-related protein) (TIN Ag-related protein) (TIN-Ag-RP) (Glucocorticoid-inducible protein 5) (Oxidized LDL-responsive gene 2 protein) (OLRG-2).

TINAL_MOUSE
NC score	0.971293 (rank : 3)	θ value	9.28496e-122 (rank : 3)
Query Neighborhood Hits	63	Target Neighborhood Hits	52	Shared Neighborhood Hits	39
SwissProt Accessions	Q99JR5, Q9EQT9	Gene names	Tinagl1, Arg1, Lcn7, Tinagl
Domain Architecture	No domain graphic available
Description	Tubulointerstitial nephritis antigen-like precursor (Androgen- regulated gene 1 protein) (Adrenocortical zonation factor 1) (AZ-1) (Tubulointerstitial nephritis antigen-related protein) (TARP).

CATB_MOUSE
NC score	0.878775 (rank : 4)	θ value	1.6247e-33 (rank : 4)
Query Neighborhood Hits	63	Target Neighborhood Hits	30	Shared Neighborhood Hits	27
SwissProt Accessions	P10605, Q3UDW7	Gene names	Ctsb
Domain Architecture
Description	Cathepsin B precursor (EC 3.4.22.1) (Cathepsin B1) [Contains: Cathepsin B light chain; Cathepsin B heavy chain].

CATB_HUMAN
NC score	0.875935 (rank : 5)	θ value	3.06405e-32 (rank : 5)
Query Neighborhood Hits	63	Target Neighborhood Hits	38	Shared Neighborhood Hits	27
SwissProt Accessions	P07858, Q96D87	Gene names	CTSB, CPSB
Domain Architecture
Description	Cathepsin B precursor (EC 3.4.22.1) (Cathepsin B1) (APP secretase) (APPS) [Contains: Cathepsin B light chain; Cathepsin B heavy chain].

CATC_MOUSE
NC score	0.844610 (rank : 6)	θ value	3.74554e-30 (rank : 6)
Query Neighborhood Hits	63	Target Neighborhood Hits	30	Shared Neighborhood Hits	27
SwissProt Accessions	P97821, O08853	Gene names	Ctsc
Domain Architecture
Description	Dipeptidyl-peptidase 1 precursor (EC 3.4.14.1) (Dipeptidyl-peptidase I) (DPP-I) (DPPI) (Cathepsin C) (Cathepsin J) (Dipeptidyl transferase) [Contains: Dipeptidyl-peptidase 1 exclusion domain chain (Dipeptidyl- peptidase I exclusion domain chain); Dipeptidyl-peptidase 1 heavy chain (Dipeptidyl-peptidase I heavy chain); Dipeptidyl-peptidase 1 light chain (Dipeptidyl-peptidase I light chain)].

CATC_HUMAN
NC score	0.842168 (rank : 7)	θ value	4.14116e-29 (rank : 7)
Query Neighborhood Hits	63	Target Neighborhood Hits	28	Shared Neighborhood Hits	27
SwissProt Accessions	P53634, Q8WYA7, Q8WYA8	Gene names	CTSC, CPPI
Domain Architecture
Description	Dipeptidyl-peptidase 1 precursor (EC 3.4.14.1) (Dipeptidyl-peptidase I) (DPP-I) (DPPI) (Cathepsin C) (Cathepsin J) (Dipeptidyl transferase) [Contains: Dipeptidyl-peptidase 1 exclusion domain chain (Dipeptidyl- peptidase I exclusion domain chain); Dipeptidyl-peptidase 1 heavy chain (Dipeptidyl-peptidase I heavy chain); Dipeptidyl-peptidase 1 light chain (Dipeptidyl-peptidase I light chain)].

CATZ_HUMAN
NC score	0.792868 (rank : 8)	θ value	1.38178e-16 (rank : 10)
Query Neighborhood Hits	63	Target Neighborhood Hits	29	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UBR2, O75331, Q9UQV5, Q9UQV6	Gene names	CTSZ
Domain Architecture
Description	Cathepsin Z precursor (EC 3.4.22.-) (Cathepsin X) (Cathepsin P).

CATZ_MOUSE
NC score	0.788863 (rank : 9)	θ value	5.8054e-15 (rank : 14)
Query Neighborhood Hits	63	Target Neighborhood Hits	29	Shared Neighborhood Hits	27
SwissProt Accessions	Q9WUU7	Gene names	Ctsz
Domain Architecture
Description	Cathepsin Z precursor (EC 3.4.22.-).

CATH_MOUSE
NC score	0.774236 (rank : 10)	θ value	3.63628e-17 (rank : 9)
Query Neighborhood Hits	63	Target Neighborhood Hits	28	Shared Neighborhood Hits	27
SwissProt Accessions	P49935	Gene names	Ctsh
Domain Architecture
Description	Cathepsin H precursor (EC 3.4.22.16) (Cathepsin B3) (Cathepsin BA) [Contains: Cathepsin H mini chain; Cathepsin H heavy chain; Cathepsin H light chain].

CATH_HUMAN
NC score	0.768306 (rank : 11)	θ value	2.60593e-15 (rank : 13)
Query Neighborhood Hits	63	Target Neighborhood Hits	29	Shared Neighborhood Hits	27
SwissProt Accessions	P09668, Q9BUM7	Gene names	CTSH
Domain Architecture
Description	Cathepsin H precursor (EC 3.4.22.16) [Contains: Cathepsin H mini chain; Cathepsin H heavy chain; Cathepsin H light chain].

CATS_HUMAN
NC score	0.749996 (rank : 12)	θ value	1.29331e-14 (rank : 15)
Query Neighborhood Hits	63	Target Neighborhood Hits	31	Shared Neighborhood Hits	27
SwissProt Accessions	P25774, Q5T5I0, Q9BUG3	Gene names	CTSS
Domain Architecture
Description	Cathepsin S precursor (EC 3.4.22.27).

CATS_MOUSE
NC score	0.742731 (rank : 13)	θ value	8.38298e-14 (rank : 17)
Query Neighborhood Hits	63	Target Neighborhood Hits	28	Shared Neighborhood Hits	27
SwissProt Accessions	O70370, O54973	Gene names	Ctss, Cats
Domain Architecture
Description	Cathepsin S precursor (EC 3.4.22.27).

CATK_MOUSE
NC score	0.742070 (rank : 14)	θ value	1.99529e-15 (rank : 12)
Query Neighborhood Hits	63	Target Neighborhood Hits	36	Shared Neighborhood Hits	27
SwissProt Accessions	P55097, O88718	Gene names	Ctsk
Domain Architecture
Description	Cathepsin K precursor (EC 3.4.22.38).

CATO_HUMAN
NC score	0.739146 (rank : 15)	θ value	3.52202e-12 (rank : 21)
Query Neighborhood Hits	63	Target Neighborhood Hits	30	Shared Neighborhood Hits	27
SwissProt Accessions	P43234	Gene names	CTSO, CTSO1
Domain Architecture
Description	Cathepsin O precursor (EC 3.4.22.42).

CATK_HUMAN
NC score	0.737689 (rank : 16)	θ value	8.95645e-16 (rank : 11)
Query Neighborhood Hits	63	Target Neighborhood Hits	34	Shared Neighborhood Hits	27
SwissProt Accessions	P43235	Gene names	CTSK, CTSO, CTSO2
Domain Architecture
Description	Cathepsin K precursor (EC 3.4.22.38) (Cathepsin O) (Cathepsin X) (Cathepsin O2).

CATL2_HUMAN
NC score	0.736073 (rank : 17)	θ value	2.7842e-17 (rank : 8)
Query Neighborhood Hits	63	Target Neighborhood Hits	34	Shared Neighborhood Hits	27
SwissProt Accessions	O60911, O60233, Q5T1U0	Gene names	CTSL2, CATL2, CTSU, CTSV
Domain Architecture
Description	Cathepsin L2 precursor (EC 3.4.22.43) (Cathepsin V) (Cathepsin U).

CATJ_MOUSE
NC score	0.733328 (rank : 18)	θ value	2.43908e-13 (rank : 19)
Query Neighborhood Hits	63	Target Neighborhood Hits	32	Shared Neighborhood Hits	27
SwissProt Accessions	Q9R014, Q564D9, Q91XK6, Q9WV51	Gene names	Ctsj, Ctsp
Domain Architecture
Description	Cathepsin J precursor (EC 3.4.22.-) (Cathepsin P) (Cathepsin L-related protein) (Catlrp-p).

CATO_MOUSE
NC score	0.730641 (rank : 19)	θ value	2.13673e-09 (rank : 25)
Query Neighborhood Hits	63	Target Neighborhood Hits	29	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BM88, Q3TM69, Q80V35, Q8BKX0	Gene names	Ctso
Domain Architecture	No domain graphic available
Description	Cathepsin O precursor (EC 3.4.22.42).

CATL_HUMAN
NC score	0.729423 (rank : 20)	θ value	1.09485e-13 (rank : 18)
Query Neighborhood Hits	63	Target Neighborhood Hits	32	Shared Neighborhood Hits	27
SwissProt Accessions	P07711, Q96QJ0	Gene names	CTSL
Domain Architecture
Description	Cathepsin L precursor (EC 3.4.22.15) (Major excreted protein) (MEP) [Contains: Cathepsin L heavy chain; Cathepsin L light chain].

CATR_MOUSE
NC score	0.728183 (rank : 21)	θ value	2.43908e-13 (rank : 20)
Query Neighborhood Hits	63	Target Neighborhood Hits	31	Shared Neighborhood Hits	27
SwissProt Accessions	Q9JIA9	Gene names	Ctsr, Catr
Domain Architecture
Description	Cathepsin R precursor (EC 3.4.22.-).

CATL_MOUSE
NC score	0.728169 (rank : 22)	θ value	2.20605e-14 (rank : 16)
Query Neighborhood Hits	63	Target Neighborhood Hits	29	Shared Neighborhood Hits	27
SwissProt Accessions	P06797, Q91UZ0	Gene names	Ctsl
Domain Architecture
Description	Cathepsin L precursor (EC 3.4.22.15) (Major excreted protein) (MEP) (p39 cysteine proteinase) [Contains: Cathepsin L heavy chain; Cathepsin L light chain].

CATW_MOUSE
NC score	0.720919 (rank : 23)	θ value	7.34386e-10 (rank : 24)
Query Neighborhood Hits	63	Target Neighborhood Hits	30	Shared Neighborhood Hits	29
SwissProt Accessions	P56203	Gene names	Ctsw
Domain Architecture
Description	Cathepsin W precursor (EC 3.4.22.-) (Lymphopain).

CATW_HUMAN
NC score	0.714725 (rank : 24)	θ value	1.9326e-10 (rank : 23)
Query Neighborhood Hits	63	Target Neighborhood Hits	29	Shared Neighborhood Hits	27
SwissProt Accessions	P56202, Q86VT4	Gene names	CTSW
Domain Architecture
Description	Cathepsin W precursor (EC 3.4.22.-) (Lymphopain).

CATM_MOUSE
NC score	0.706065 (rank : 25)	θ value	4.59992e-12 (rank : 22)
Query Neighborhood Hits	63	Target Neighborhood Hits	30	Shared Neighborhood Hits	27
SwissProt Accessions	Q9JL96, Q91Z75, Q91ZF3, Q9CQB9	Gene names	Ctsm, Catm
Domain Architecture
Description	Cathepsin M precursor (EC 3.4.22.-).

CATF_HUMAN
NC score	0.686294 (rank : 26)	θ value	4.92598e-06 (rank : 26)
Query Neighborhood Hits	63	Target Neighborhood Hits	37	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UBX1, O95240, Q9NSU4, Q9UKQ5	Gene names	CTSF
Domain Architecture
Description	Cathepsin F precursor (EC 3.4.22.41) (CATSF).

CATF_MOUSE
NC score	0.683766 (rank : 27)	θ value	0.000121331 (rank : 29)
Query Neighborhood Hits	63	Target Neighborhood Hits	30	Shared Neighborhood Hits	27
SwissProt Accessions	Q9R013, Q9WUT4	Gene names	Ctsf
Domain Architecture
Description	Cathepsin F precursor (EC 3.4.22.41).

CTL2A_MOUSE
NC score	0.381962 (rank : 28)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	63	Target Neighborhood Hits	20	Shared Neighborhood Hits	16
SwissProt Accessions	P12399	Gene names	Ctla2a
Domain Architecture	No domain graphic available
Description	CTLA-2-alpha protein precursor.

TSP_MOUSE
NC score	0.241145 (rank : 29)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	63	Target Neighborhood Hits	15	Shared Neighborhood Hits	9
SwissProt Accessions	P13438	Gene names	Tpbpa, Tpbp
Domain Architecture	No domain graphic available
Description	Trophoblast-specific protein alpha precursor.

VWF_HUMAN
NC score	0.152034 (rank : 30)	θ value	2.44474e-05 (rank : 27)
Query Neighborhood Hits	63	Target Neighborhood Hits	396	Shared Neighborhood Hits	28
SwissProt Accessions	P04275	Gene names	VWF, F8VWF
Domain Architecture
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

VWF_MOUSE
NC score	0.149922 (rank : 31)	θ value	5.44631e-05 (rank : 28)
Query Neighborhood Hits	63	Target Neighborhood Hits	381	Shared Neighborhood Hits	27
SwissProt Accessions	Q8CIZ8, Q60863, Q6XUV6, Q8BIU9, Q8CGN0, Q9JK16	Gene names	Vwf
Domain Architecture	No domain graphic available
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

MUC5B_HUMAN
NC score	0.136786 (rank : 32)	θ value	0.000602161 (rank : 32)
Query Neighborhood Hits	63	Target Neighborhood Hits	1020	Shared Neighborhood Hits	30
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

BMPER_HUMAN
NC score	0.119727 (rank : 33)	θ value	0.47712 (rank : 39)
Query Neighborhood Hits	63	Target Neighborhood Hits	175	Shared Neighborhood Hits	23
SwissProt Accessions	Q8N8U9	Gene names	BMPER
Domain Architecture
Description	BMP-binding endothelial regulator protein precursor (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (hCV2).

MUC2_HUMAN
NC score	0.118883 (rank : 34)	θ value	0.000602161 (rank : 31)
Query Neighborhood Hits	63	Target Neighborhood Hits	906	Shared Neighborhood Hits	28
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

SSPO_MOUSE
NC score	0.106195 (rank : 35)	θ value	0.000461057 (rank : 30)
Query Neighborhood Hits	63	Target Neighborhood Hits	800	Shared Neighborhood Hits	31
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

BMPER_MOUSE
NC score	0.104057 (rank : 36)	θ value	1.06291 (rank : 47)
Query Neighborhood Hits	63	Target Neighborhood Hits	194	Shared Neighborhood Hits	27
SwissProt Accessions	Q8CJ69, Q7TN57, Q80UZ1, Q9CXM8	Gene names	Bmper, Cv2
Domain Architecture
Description	BMP-binding endothelial regulator protein precursor (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (mCV2).

ENPP3_HUMAN
NC score	0.094474 (rank : 37)	θ value	0.00134147 (rank : 33)
Query Neighborhood Hits	63	Target Neighborhood Hits	34	Shared Neighborhood Hits	9
SwissProt Accessions	O14638	Gene names	ENPP3, PDNP3
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 3 (E-NPP 3) (Phosphodiesterase I/nucleotide pyrophosphatase 3) (Phosphodiesterase I beta) (PD-Ibeta) (CD203c antigen) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP1_HUMAN
NC score	0.087795 (rank : 38)	θ value	0.0330416 (rank : 34)
Query Neighborhood Hits	63	Target Neighborhood Hits	47	Shared Neighborhood Hits	11
SwissProt Accessions	P22413, Q5T9R6, Q9NPZ3, Q9P1P6, Q9UP61, Q9Y6K3	Gene names	ENPP1, NPPS, PC1, PDNP1
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP1_MOUSE
NC score	0.086801 (rank : 39)	θ value	0.0563607 (rank : 35)
Query Neighborhood Hits	63	Target Neighborhood Hits	65	Shared Neighborhood Hits	9
SwissProt Accessions	P06802	Gene names	Enpp1, Npps, Pc1, Pdnp1
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) (Antigen Ly-41) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP2_MOUSE
NC score	0.083087 (rank : 40)	θ value	0.47712 (rank : 40)
Query Neighborhood Hits	63	Target Neighborhood Hits	66	Shared Neighborhood Hits	13
SwissProt Accessions	Q9R1E6, Q99LG9	Gene names	Enpp2, Npps2
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2) (Phosphodiesterase I/nucleotide pyrophosphatase 2) (Phosphodiesterase I alpha) (PD-Ialpha) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP2_HUMAN
NC score	0.080230 (rank : 41)	θ value	0.62314 (rank : 43)
Query Neighborhood Hits	63	Target Neighborhood Hits	61	Shared Neighborhood Hits	14
SwissProt Accessions	Q13822, Q13827, Q15117	Gene names	ENPP2, ATX, PDNP2
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2) (Phosphodiesterase I/nucleotide pyrophosphatase 2) (Phosphodiesterase I alpha) (PD-Ialpha) (Autotaxin) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

TECTA_MOUSE
NC score	0.073256 (rank : 42)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	63	Target Neighborhood Hits	244	Shared Neighborhood Hits	27
SwissProt Accessions	O08523	Gene names	Tecta
Domain Architecture
Description	Alpha-tectorin precursor.

TECTA_HUMAN
NC score	0.072885 (rank : 43)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	63	Target Neighborhood Hits	239	Shared Neighborhood Hits	23
SwissProt Accessions	O75443	Gene names	TECTA
Domain Architecture
Description	Alpha-tectorin precursor.

FSTL1_MOUSE
NC score	0.071069 (rank : 44)	θ value	0.125558 (rank : 36)
Query Neighborhood Hits	63	Target Neighborhood Hits	74	Shared Neighborhood Hits	10
SwissProt Accessions	Q62356, Q99JI9	Gene names	Fstl1, Frp, Fstl, Tsc36
Domain Architecture
Description	Follistatin-related protein 1 precursor (Follistatin-like 1) (TGF- beta-inducible protein TSC-36).

ZAN_HUMAN
NC score	0.070824 (rank : 45)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	63	Target Neighborhood Hits	679	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

FSTL1_HUMAN
NC score	0.070387 (rank : 46)	θ value	0.21417 (rank : 38)
Query Neighborhood Hits	63	Target Neighborhood Hits	68	Shared Neighborhood Hits	10
SwissProt Accessions	Q12841	Gene names	FSTL1, FRP
Domain Architecture
Description	Follistatin-related protein 1 precursor (Follistatin-like 1).

CRIM1_HUMAN
NC score	0.069616 (rank : 47)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	63	Target Neighborhood Hits	362	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

ZAN_MOUSE
NC score	0.069237 (rank : 48)	θ value	3.0926 (rank : 55)
Query Neighborhood Hits	63	Target Neighborhood Hits	808	Shared Neighborhood Hits	30
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

PRG4_HUMAN
NC score	0.049948 (rank : 49)	θ value	0.125558 (rank : 37)
Query Neighborhood Hits	63	Target Neighborhood Hits	764	Shared Neighborhood Hits	13
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

RECK_HUMAN
NC score	0.046136 (rank : 50)	θ value	8.99809 (rank : 63)
Query Neighborhood Hits	63	Target Neighborhood Hits	189	Shared Neighborhood Hits	26
SwissProt Accessions	O95980, Q8WX37	Gene names	RECK
Domain Architecture
Description	Reversion-inducing cysteine-rich protein with Kazal motifs precursor (hRECK) (Suppressor of tumorigenicity 15) (ST15).

FRAS1_MOUSE
NC score	0.042515 (rank : 51)	θ value	2.36792 (rank : 54)
Query Neighborhood Hits	63	Target Neighborhood Hits	747	Shared Neighborhood Hits	26
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

FRAS1_HUMAN
NC score	0.042381 (rank : 52)	θ value	1.81305 (rank : 52)
Query Neighborhood Hits	63	Target Neighborhood Hits	759	Shared Neighborhood Hits	27
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

PRG4_MOUSE
NC score	0.038449 (rank : 53)	θ value	0.47712 (rank : 42)
Query Neighborhood Hits	63	Target Neighborhood Hits	624	Shared Neighborhood Hits	10
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

WISP1_HUMAN
NC score	0.037351 (rank : 54)	θ value	0.813845 (rank : 46)
Query Neighborhood Hits	63	Target Neighborhood Hits	121	Shared Neighborhood Hits	17
SwissProt Accessions	O95388, Q9HCS3	Gene names	WISP1, CCN4
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (Wnt-1- induced secreted protein).

LRP1B_HUMAN
NC score	0.034774 (rank : 55)	θ value	0.813845 (rank : 44)
Query Neighborhood Hits	63	Target Neighborhood Hits	602	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

LRP1B_MOUSE
NC score	0.034457 (rank : 56)	θ value	0.813845 (rank : 45)
Query Neighborhood Hits	63	Target Neighborhood Hits	606	Shared Neighborhood Hits	28
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

LRP2_HUMAN
NC score	0.032980 (rank : 57)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	63	Target Neighborhood Hits	573	Shared Neighborhood Hits	28
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

WISP1_MOUSE
NC score	0.032812 (rank : 58)	θ value	5.27518 (rank : 59)
Query Neighborhood Hits	63	Target Neighborhood Hits	123	Shared Neighborhood Hits	15
SwissProt Accessions	O54775, Q80ZL1	Gene names	Wisp1, Ccn4, Elm1
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (ELM-1).

VLDLR_HUMAN
NC score	0.031999 (rank : 59)	θ value	1.38821 (rank : 51)
Query Neighborhood Hits	63	Target Neighborhood Hits	383	Shared Neighborhood Hits	21
SwissProt Accessions	P98155, Q5VVF6	Gene names	VLDLR
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

LRP1_HUMAN
NC score	0.031503 (rank : 60)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	63	Target Neighborhood Hits	617	Shared Neighborhood Hits	27
SwissProt Accessions	Q07954, Q2PP12, Q8IVG8	Gene names	LRP1, A2MR
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1 precursor (LRP) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD91 antigen).

VLDLR_MOUSE
NC score	0.030037 (rank : 61)	θ value	4.03905 (rank : 57)
Query Neighborhood Hits	63	Target Neighborhood Hits	360	Shared Neighborhood Hits	20
SwissProt Accessions	P98156, Q64022	Gene names	Vldlr
Domain Architecture
Description	Very low-density lipoprotein receptor precursor (VLDL receptor) (VLDL- R).

JAG2_MOUSE
NC score	0.028694 (rank : 62)	θ value	1.06291 (rank : 48)
Query Neighborhood Hits	63	Target Neighborhood Hits	504	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QYE5, O55139, O70219	Gene names	Jag2
Domain Architecture
Description	Jagged-2 precursor (Jagged2).

JAG2_HUMAN
NC score	0.026497 (rank : 63)	θ value	1.38821 (rank : 49)
Query Neighborhood Hits	63	Target Neighborhood Hits	491	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y219, Q9UE17, Q9UE99, Q9UNK8, Q9Y6P9, Q9Y6Q0	Gene names	JAG2
Domain Architecture
Description	Jagged-2 precursor (Jagged2) (HJ2).

GALM_HUMAN
NC score	0.025779 (rank : 64)	θ value	1.81305 (rank : 53)
Query Neighborhood Hits	63	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	Q96C23, Q8NIA2	Gene names	GALM
Domain Architecture	No domain graphic available
Description	Aldose 1-epimerase (EC 5.1.3.3) (Galactose mutarotase) (BLOCK25 protein).

NOTC1_MOUSE
NC score	0.025400 (rank : 65)	θ value	8.99809 (rank : 62)
Query Neighborhood Hits	63	Target Neighborhood Hits	916	Shared Neighborhood Hits	29
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

NOTC1_HUMAN
NC score	0.022217 (rank : 66)	θ value	1.38821 (rank : 50)
Query Neighborhood Hits	63	Target Neighborhood Hits	906	Shared Neighborhood Hits	27
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

TSP2_HUMAN
NC score	0.020224 (rank : 67)	θ value	4.03905 (rank : 56)
Query Neighborhood Hits	63	Target Neighborhood Hits	359	Shared Neighborhood Hits	21
SwissProt Accessions	P35442	Gene names	THBS2, TSP2
Domain Architecture
Description	Thrombospondin-2 precursor.

FA10_MOUSE
NC score	0.011274 (rank : 68)	θ value	0.47712 (rank : 41)
Query Neighborhood Hits	63	Target Neighborhood Hits	435	Shared Neighborhood Hits	15
SwissProt Accessions	O88947, O54740, Q99L32	Gene names	F10
Domain Architecture
Description	Coagulation factor X precursor (EC 3.4.21.6) (Stuart factor) [Contains: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain].

FA10_HUMAN
NC score	0.008146 (rank : 69)	θ value	6.88961 (rank : 60)
Query Neighborhood Hits	63	Target Neighborhood Hits	431	Shared Neighborhood Hits	15
SwissProt Accessions	P00742, Q14340	Gene names	F10
Domain Architecture
Description	Coagulation factor X precursor (EC 3.4.21.6) (Stuart factor) (Stuart- Prower factor) [Contains: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain].