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Network neighborhood for query Sequence : ENPP2_MOUSE

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ENPP2_MOUSE
SwissProt Accessions	Q9R1E6, Q99LG9	Gene names	Enpp2, Npps2
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2) (Phosphodiesterase I/nucleotide pyrophosphatase 2) (Phosphodiesterase I alpha) (PD-Ialpha) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ENPP1_HUMAN
θ value	0 (rank : 1)	NC score	0.975756 (rank : 4)
Query Neighborhood Hits	66	Target Neighborhood Hits	47	Shared Neighborhood Hits	28
SwissProt Accessions	P22413, Q5T9R6, Q9NPZ3, Q9P1P6, Q9UP61, Q9Y6K3	Gene names	ENPP1, NPPS, PC1, PDNP1
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP1_MOUSE
θ value	0 (rank : 2)	NC score	0.974011 (rank : 5)
Query Neighborhood Hits	66	Target Neighborhood Hits	65	Shared Neighborhood Hits	30
SwissProt Accessions	P06802	Gene names	Enpp1, Npps, Pc1, Pdnp1
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) (Antigen Ly-41) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP2_HUMAN
θ value	0 (rank : 3)	NC score	0.997442 (rank : 2)
Query Neighborhood Hits	66	Target Neighborhood Hits	61	Shared Neighborhood Hits	50
SwissProt Accessions	Q13822, Q13827, Q15117	Gene names	ENPP2, ATX, PDNP2
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2) (Phosphodiesterase I/nucleotide pyrophosphatase 2) (Phosphodiesterase I alpha) (PD-Ialpha) (Autotaxin) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP2_MOUSE
θ value	0 (rank : 4)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	66	Target Neighborhood Hits	66	Shared Neighborhood Hits	66
SwissProt Accessions	Q9R1E6, Q99LG9	Gene names	Enpp2, Npps2
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2) (Phosphodiesterase I/nucleotide pyrophosphatase 2) (Phosphodiesterase I alpha) (PD-Ialpha) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP3_HUMAN
θ value	0 (rank : 5)	NC score	0.977117 (rank : 3)
Query Neighborhood Hits	66	Target Neighborhood Hits	34	Shared Neighborhood Hits	19
SwissProt Accessions	O14638	Gene names	ENPP3, PDNP3
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 3 (E-NPP 3) (Phosphodiesterase I/nucleotide pyrophosphatase 3) (Phosphodiesterase I beta) (PD-Ibeta) (CD203c antigen) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP5_MOUSE
θ value	8.02596e-49 (rank : 6)	NC score	0.867167 (rank : 8)
Query Neighborhood Hits	66	Target Neighborhood Hits	14	Shared Neighborhood Hits	12
SwissProt Accessions	Q9EQG7, Q921P7	Gene names	Enpp5
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 5 precursor (EC 3.1.-.-) (E-NPP5) (NPP-5).

ENPP5_HUMAN
θ value	1.788e-48 (rank : 7)	NC score	0.867380 (rank : 7)
Query Neighborhood Hits	66	Target Neighborhood Hits	16	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UJA9, Q6UX49	Gene names	ENPP5
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 5 precursor (EC 3.1.-.-) (E-NPP5) (NPP-5).

ENPP7_HUMAN
θ value	9.81109e-47 (rank : 8)	NC score	0.875613 (rank : 6)
Query Neighborhood Hits	66	Target Neighborhood Hits	30	Shared Neighborhood Hits	14
SwissProt Accessions	Q6UWV6, Q6ZTS5, Q8IUS8	Gene names	ENPP7
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 7 precursor (EC 3.1.4.12) (E-NPP7) (NPP-7) (Alkaline sphingomyelin phosphodiesterase) (Intestinal alkaline sphingomyelinase) (Alk-SMase).

ENPP6_MOUSE
θ value	3.15612e-45 (rank : 9)	NC score	0.852084 (rank : 10)
Query Neighborhood Hits	66	Target Neighborhood Hits	16	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BGN3, Q4VAH5	Gene names	Enpp6
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 6 precursor (EC 3.1.-.-) (E-NPP6) (NPP-6) [Contains: Ectonucleotide pyrophosphatase/phosphodiesterase 6 soluble form].

ENPP6_HUMAN
θ value	5.38352e-45 (rank : 10)	NC score	0.852961 (rank : 9)
Query Neighborhood Hits	66	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	Q6UWR7, Q96M57	Gene names	ENPP6
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 6 precursor (EC 3.1.-.-) (E-NPP6) (NPP-6) [Contains: Ectonucleotide pyrophosphatase/phosphodiesterase 6 soluble form].

PRG4_MOUSE
θ value	3.08544e-08 (rank : 11)	NC score	0.202400 (rank : 12)
Query Neighborhood Hits	66	Target Neighborhood Hits	624	Shared Neighborhood Hits	20
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PRG4_HUMAN
θ value	7.59969e-07 (rank : 12)	NC score	0.179723 (rank : 13)
Query Neighborhood Hits	66	Target Neighborhood Hits	764	Shared Neighborhood Hits	17
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

VTNC_HUMAN
θ value	0.00102713 (rank : 13)	NC score	0.158851 (rank : 17)
Query Neighborhood Hits	66	Target Neighborhood Hits	66	Shared Neighborhood Hits	12
SwissProt Accessions	P04004, P01141, Q9BSH7	Gene names	VTN
Domain Architecture
Description	Vitronectin precursor (Serum-spreading factor) (S-protein) (V75) [Contains: Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin B].

VTNC_MOUSE
θ value	0.00102713 (rank : 14)	NC score	0.165536 (rank : 14)
Query Neighborhood Hits	66	Target Neighborhood Hits	74	Shared Neighborhood Hits	11
SwissProt Accessions	P29788, Q8VII4	Gene names	Vtn
Domain Architecture
Description	Vitronectin precursor (Serum-spreading factor) (S-protein).

PP11_HUMAN
θ value	0.00298849 (rank : 15)	NC score	0.300217 (rank : 11)
Query Neighborhood Hits	66	Target Neighborhood Hits	20	Shared Neighborhood Hits	12
SwissProt Accessions	P21128, Q2NKJ4	Gene names
Domain Architecture
Description	Placental protein 11 precursor (EC 3.4.21.-) (PP11).

LTBP2_HUMAN
θ value	0.00509761 (rank : 16)	NC score	0.051775 (rank : 27)
Query Neighborhood Hits	66	Target Neighborhood Hits	552	Shared Neighborhood Hits	35
SwissProt Accessions	Q14767, Q99907, Q9NS51	Gene names	LTBP2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

PIGO_HUMAN
θ value	0.0113563 (rank : 17)	NC score	0.165290 (rank : 15)
Query Neighborhood Hits	66	Target Neighborhood Hits	24	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TEQ8, Q6P154, Q6UX80, Q8TDS8, Q96CS9, Q9BVN9, Q9Y4B0	Gene names	PIGO
Domain Architecture
Description	GPI ethanolamine phosphate transferase 3 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class O protein) (PIG-O).

PIGO_MOUSE
θ value	0.0113563 (rank : 18)	NC score	0.159368 (rank : 16)
Query Neighborhood Hits	66	Target Neighborhood Hits	21	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JJI6, Q9CRY2	Gene names	Pigo
Domain Architecture
Description	GPI ethanolamine phosphate transferase 3 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class O protein) (PIG-O).

KRA59_HUMAN
θ value	0.0193708 (rank : 19)	NC score	0.080379 (rank : 22)
Query Neighborhood Hits	66	Target Neighborhood Hits	310	Shared Neighborhood Hits	32
SwissProt Accessions	P26371, Q14564	Gene names	KRTAP5-9, KAP5.9, KRN1, KRTAP5.9, UHSK1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-9 (Keratin-associated protein 5.9) (Ultrahigh sulfur keratin-associated protein 5.9) (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (UHS keratin A) (UHS KerA).

TENA_MOUSE
θ value	0.0193708 (rank : 20)	NC score	0.048490 (rank : 30)
Query Neighborhood Hits	66	Target Neighborhood Hits	596	Shared Neighborhood Hits	35
SwissProt Accessions	Q80YX1, Q64706, Q80YX2	Gene names	Tnc, Hxb
Domain Architecture	No domain graphic available
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion).

NOTC4_MOUSE
θ value	0.0563607 (rank : 21)	NC score	0.036301 (rank : 46)
Query Neighborhood Hits	66	Target Neighborhood Hits	872	Shared Neighborhood Hits	37
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

ARSA_HUMAN
θ value	0.0961366 (rank : 22)	NC score	0.051361 (rank : 28)
Query Neighborhood Hits	66	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	P15289, Q6ICI5, Q96CJ0	Gene names	ARSA
Domain Architecture
Description	Arylsulfatase A precursor (EC 3.1.6.8) (ASA) (Cerebroside-sulfatase) [Contains: Arylsulfatase A component B; Arylsulfatase A component C].

ADA28_HUMAN
θ value	0.125558 (rank : 23)	NC score	0.026614 (rank : 60)
Query Neighborhood Hits	66	Target Neighborhood Hits	244	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UKQ2, Q9Y339, Q9Y3S0	Gene names	ADAM28, MDCL
Domain Architecture
Description	ADAM 28 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 28) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein-L) (MDC-L) (eMDC II) (ADAM23).

LTBP2_MOUSE
θ value	0.125558 (rank : 24)	NC score	0.047185 (rank : 32)
Query Neighborhood Hits	66	Target Neighborhood Hits	617	Shared Neighborhood Hits	36
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

TENA_HUMAN
θ value	0.163984 (rank : 25)	NC score	0.047347 (rank : 31)
Query Neighborhood Hits	66	Target Neighborhood Hits	631	Shared Neighborhood Hits	37
SwissProt Accessions	P24821, Q14583, Q15567	Gene names	TNC, HXB
Domain Architecture
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Myotendinous antigen) (Glioma- associated-extracellular matrix antigen) (GP 150-225).

TECTA_MOUSE
θ value	0.21417 (rank : 26)	NC score	0.033545 (rank : 50)
Query Neighborhood Hits	66	Target Neighborhood Hits	244	Shared Neighborhood Hits	27
SwissProt Accessions	O08523	Gene names	Tecta
Domain Architecture
Description	Alpha-tectorin precursor.

FBN2_HUMAN
θ value	0.279714 (rank : 27)	NC score	0.043353 (rank : 37)
Query Neighborhood Hits	66	Target Neighborhood Hits	560	Shared Neighborhood Hits	36
SwissProt Accessions	P35556	Gene names	FBN2
Domain Architecture
Description	Fibrillin-2 precursor.

FSTL5_HUMAN
θ value	0.279714 (rank : 28)	NC score	0.029745 (rank : 55)
Query Neighborhood Hits	66	Target Neighborhood Hits	347	Shared Neighborhood Hits	8
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

SUSD2_HUMAN
θ value	0.279714 (rank : 29)	NC score	0.099604 (rank : 19)
Query Neighborhood Hits	66	Target Neighborhood Hits	99	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UGT4, Q9H5Y6	Gene names	SUSD2
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 2 precursor.

LRP1B_HUMAN
θ value	0.365318 (rank : 30)	NC score	0.040280 (rank : 42)
Query Neighborhood Hits	66	Target Neighborhood Hits	602	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

MEGF6_HUMAN
θ value	0.365318 (rank : 31)	NC score	0.040433 (rank : 39)
Query Neighborhood Hits	66	Target Neighborhood Hits	671	Shared Neighborhood Hits	34
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

TENR_HUMAN
θ value	0.365318 (rank : 32)	NC score	0.045526 (rank : 34)
Query Neighborhood Hits	66	Target Neighborhood Hits	526	Shared Neighborhood Hits	34
SwissProt Accessions	Q92752, Q15568, Q5R3G0	Gene names	TNR
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin).

TENR_MOUSE
θ value	0.365318 (rank : 33)	NC score	0.043960 (rank : 35)
Query Neighborhood Hits	66	Target Neighborhood Hits	531	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BYI9, O88717	Gene names	Tnr
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin) (Neural recognition molecule J1-160/180).

TINAG_HUMAN
θ value	0.47712 (rank : 34)	NC score	0.083087 (rank : 20)
Query Neighborhood Hits	66	Target Neighborhood Hits	63	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UJW2, Q9UJW1, Q9ULZ4	Gene names	TINAG
Domain Architecture
Description	Tubulointerstitial nephritis antigen (TIN-Ag).

ARSA_MOUSE
θ value	0.62314 (rank : 35)	NC score	0.040396 (rank : 40)
Query Neighborhood Hits	66	Target Neighborhood Hits	30	Shared Neighborhood Hits	6
SwissProt Accessions	P50428	Gene names	Arsa, As2
Domain Architecture
Description	Arylsulfatase A precursor (EC 3.1.6.8) (ASA) (Cerebroside-sulfatase).

CNBP_MOUSE
θ value	1.06291 (rank : 36)	NC score	0.041400 (rank : 38)
Query Neighborhood Hits	66	Target Neighborhood Hits	215	Shared Neighborhood Hits	3
SwissProt Accessions	P53996, Q80Y06, Q8BP23	Gene names	Cnbp, Cnbp1, Znf9
Domain Architecture	No domain graphic available
Description	Cellular nucleic acid-binding protein (CNBP) (Zinc finger protein 9).

FSTL4_HUMAN
θ value	1.38821 (rank : 37)	NC score	0.026130 (rank : 61)
Query Neighborhood Hits	66	Target Neighborhood Hits	344	Shared Neighborhood Hits	13
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

KRA53_HUMAN
θ value	1.38821 (rank : 38)	NC score	0.049337 (rank : 29)
Query Neighborhood Hits	66	Target Neighborhood Hits	331	Shared Neighborhood Hits	31
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

KRA58_HUMAN
θ value	1.38821 (rank : 39)	NC score	0.058485 (rank : 24)
Query Neighborhood Hits	66	Target Neighborhood Hits	324	Shared Neighborhood Hits	31
SwissProt Accessions	O75690, Q6L8G7, Q6UTX6	Gene names	KRTAP5-8, KAP5.8, KRTAP5.8, UHSKB
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-8 (Keratin-associated protein 5.8) (Ultrahigh sulfur keratin-associated protein 5.8) (Keratin, ultra high-sulfur matrix protein B) (UHS keratin B) (UHS KerB).

LRP2_HUMAN
θ value	1.38821 (rank : 40)	NC score	0.037553 (rank : 45)
Query Neighborhood Hits	66	Target Neighborhood Hits	573	Shared Neighborhood Hits	39
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

SUSD2_MOUSE
θ value	1.38821 (rank : 41)	NC score	0.083021 (rank : 21)
Query Neighborhood Hits	66	Target Neighborhood Hits	104	Shared Neighborhood Hits	15
SwissProt Accessions	Q9DBX3, Q8BY19, Q8BYN0, Q8BYZ3, Q8BYZ9, Q8BZQ4, Q8C179	Gene names	Susd2
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 2 precursor.

FBN2_MOUSE
θ value	1.81305 (rank : 42)	NC score	0.040391 (rank : 41)
Query Neighborhood Hits	66	Target Neighborhood Hits	549	Shared Neighborhood Hits	37
SwissProt Accessions	Q61555, Q63957	Gene names	Fbn2, Fbn-2
Domain Architecture
Description	Fibrillin-2 precursor.

TENX_HUMAN
θ value	2.36792 (rank : 43)	NC score	0.039650 (rank : 43)
Query Neighborhood Hits	66	Target Neighborhood Hits	789	Shared Neighborhood Hits	35
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

FSTL4_MOUSE
θ value	3.0926 (rank : 44)	NC score	0.024949 (rank : 62)
Query Neighborhood Hits	66	Target Neighborhood Hits	333	Shared Neighborhood Hits	10
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

TENN_HUMAN
θ value	3.0926 (rank : 45)	NC score	0.035323 (rank : 49)
Query Neighborhood Hits	66	Target Neighborhood Hits	453	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UQP3, Q5R360	Gene names	TNN
Domain Architecture
Description	Tenascin-N precursor (TN-N).

ARSF_HUMAN
θ value	4.03905 (rank : 46)	NC score	0.029261 (rank : 56)
Query Neighborhood Hits	66	Target Neighborhood Hits	33	Shared Neighborhood Hits	8
SwissProt Accessions	P54793, Q8TCC5	Gene names	ARSF
Domain Architecture
Description	Arylsulfatase F precursor (EC 3.1.6.-) (ASF).

FBN3_HUMAN
θ value	4.03905 (rank : 47)	NC score	0.036128 (rank : 47)
Query Neighborhood Hits	66	Target Neighborhood Hits	543	Shared Neighborhood Hits	34
SwissProt Accessions	Q75N90, Q75N91, Q75N92, Q75N93, Q86SJ5, Q96JP8	Gene names	FBN3, KIAA1776
Domain Architecture	No domain graphic available
Description	Fibrillin-3 precursor.

LRP1_HUMAN
θ value	4.03905 (rank : 48)	NC score	0.032652 (rank : 51)
Query Neighborhood Hits	66	Target Neighborhood Hits	617	Shared Neighborhood Hits	37
SwissProt Accessions	Q07954, Q2PP12, Q8IVG8	Gene names	LRP1, A2MR
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1 precursor (LRP) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD91 antigen).

NOTC2_MOUSE
θ value	4.03905 (rank : 49)	NC score	0.032097 (rank : 52)
Query Neighborhood Hits	66	Target Neighborhood Hits	1069	Shared Neighborhood Hits	40
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

WFDC8_HUMAN
θ value	4.03905 (rank : 50)	NC score	0.029104 (rank : 57)
Query Neighborhood Hits	66	Target Neighborhood Hits	82	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IUA0, Q5TDV2, Q96A34	Gene names	WFDC8, C20orf170, WAP8
Domain Architecture
Description	WAP four-disulfide core domain protein 8 precursor (Putative protease inhibitor WAP8).

STS_MOUSE
θ value	5.27518 (rank : 51)	NC score	0.028335 (rank : 59)
Query Neighborhood Hits	66	Target Neighborhood Hits	38	Shared Neighborhood Hits	8
SwissProt Accessions	P50427	Gene names	Sts
Domain Architecture
Description	Steryl-sulfatase precursor (EC 3.1.6.2) (Steroid sulfatase) (Steryl- sulfate sulfohydrolase) (Arylsulfatase C) (ASC).

ADAM2_HUMAN
θ value	6.88961 (rank : 52)	NC score	0.016205 (rank : 66)
Query Neighborhood Hits	66	Target Neighborhood Hits	175	Shared Neighborhood Hits	25
SwissProt Accessions	Q99965, P78326, Q9UQQ8	Gene names	ADAM2, FTNB
Domain Architecture
Description	ADAM 2 precursor (A disintegrin and metalloproteinase domain 2) (Fertilin subunit beta) (PH-30) (PH30).

CFAI_MOUSE
θ value	6.88961 (rank : 53)	NC score	0.005679 (rank : 70)
Query Neighborhood Hits	66	Target Neighborhood Hits	290	Shared Neighborhood Hits	18
SwissProt Accessions	Q61129, Q9WU07	Gene names	Cfi, If
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

FRAS1_HUMAN
θ value	6.88961 (rank : 54)	NC score	0.022544 (rank : 63)
Query Neighborhood Hits	66	Target Neighborhood Hits	759	Shared Neighborhood Hits	33
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

GRN_HUMAN
θ value	6.88961 (rank : 55)	NC score	0.043734 (rank : 36)
Query Neighborhood Hits	66	Target Neighborhood Hits	268	Shared Neighborhood Hits	31
SwissProt Accessions	P28799, P23781, P23782, P23783, P23784, Q9BWE7, Q9UCH0	Gene names	GRN
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin; Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)].

KRA57_HUMAN
θ value	6.88961 (rank : 56)	NC score	0.046191 (rank : 33)
Query Neighborhood Hits	66	Target Neighborhood Hits	269	Shared Neighborhood Hits	29
SwissProt Accessions	Q6L8G8, Q701N5	Gene names	KRTAP5-7, KAP5-7, KAP5.3, KRTAP5.3, KRTAP5.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-7 (Keratin-associated protein 5.7) (Ultrahigh sulfur keratin-associated protein 5.7) (Keratin-associated protein 5-3) (Keratin-associated protein 5.3).

PGBM_MOUSE
θ value	6.88961 (rank : 57)	NC score	0.013107 (rank : 67)
Query Neighborhood Hits	66	Target Neighborhood Hits	1073	Shared Neighborhood Hits	34
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

TINAL_MOUSE
θ value	6.88961 (rank : 58)	NC score	0.016982 (rank : 64)
Query Neighborhood Hits	66	Target Neighborhood Hits	52	Shared Neighborhood Hits	9
SwissProt Accessions	Q99JR5, Q9EQT9	Gene names	Tinagl1, Arg1, Lcn7, Tinagl
Domain Architecture	No domain graphic available
Description	Tubulointerstitial nephritis antigen-like precursor (Androgen- regulated gene 1 protein) (Adrenocortical zonation factor 1) (AZ-1) (Tubulointerstitial nephritis antigen-related protein) (TARP).

ADA28_MOUSE
θ value	8.99809 (rank : 59)	NC score	0.016378 (rank : 65)
Query Neighborhood Hits	66	Target Neighborhood Hits	241	Shared Neighborhood Hits	29
SwissProt Accessions	Q9JLN6, Q8K5D2, Q8K5D3	Gene names	Adam28
Domain Architecture
Description	ADAM 28 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 28) (Thymic epithelial cell-ADAM) (TECADAM).

AGRIN_HUMAN
θ value	8.99809 (rank : 60)	NC score	0.028858 (rank : 58)
Query Neighborhood Hits	66	Target Neighborhood Hits	582	Shared Neighborhood Hits	38
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

AS3MT_HUMAN
θ value	8.99809 (rank : 61)	NC score	0.009580 (rank : 68)
Query Neighborhood Hits	66	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HBK9	Gene names	AS3MT, CYT19
Domain Architecture	No domain graphic available
Description	Arsenite methyltransferase (EC 2.1.1.137) (S-adenosyl-L- methionine:arsenic(III) methyltransferase) (Methylarsonite methyltransferase).

FBN1_HUMAN
θ value	8.99809 (rank : 62)	NC score	0.039359 (rank : 44)
Query Neighborhood Hits	66	Target Neighborhood Hits	557	Shared Neighborhood Hits	37
SwissProt Accessions	P35555, Q15972, Q75N87	Gene names	FBN1, FBN
Domain Architecture
Description	Fibrillin-1 precursor.

KRA51_HUMAN
θ value	8.99809 (rank : 63)	NC score	0.035784 (rank : 48)
Query Neighborhood Hits	66	Target Neighborhood Hits	288	Shared Neighborhood Hits	27
SwissProt Accessions	Q6L8H4	Gene names	KRTAP5-1, KAP5.1, KRTAP5.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-1 (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1).

NOTC4_HUMAN
θ value	8.99809 (rank : 64)	NC score	0.030671 (rank : 54)
Query Neighborhood Hits	66	Target Neighborhood Hits	905	Shared Neighborhood Hits	34
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

SCUB3_MOUSE
θ value	8.99809 (rank : 65)	NC score	0.031470 (rank : 53)
Query Neighborhood Hits	66	Target Neighborhood Hits	442	Shared Neighborhood Hits	31
SwissProt Accessions	Q66PY1, Q68FG9	Gene names	Scube3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

SEZ6L_HUMAN
θ value	8.99809 (rank : 66)	NC score	0.006426 (rank : 69)
Query Neighborhood Hits	66	Target Neighborhood Hits	289	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BYH1, O95917, Q5THY5, Q6IBZ4, Q6UXD4, Q9NUI3, Q9NUI4, Q9NUI5, Q9Y2E1, Q9Y3J6	Gene names	SEZ6L, KIAA0927
Domain Architecture
Description	Seizure 6-like protein precursor.

KRA54_HUMAN
θ value	θ > 10 (rank : 67)	NC score	0.055659 (rank : 25)
Query Neighborhood Hits	66	Target Neighborhood Hits	270	Shared Neighborhood Hits	30
SwissProt Accessions	Q6L8H1	Gene names	KRTAP5-4, KAP5.4, KRTAP5.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-4 (Keratin-associated protein 5.4) (Ultrahigh sulfur keratin-associated protein 5.4).

PIGG_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.131506 (rank : 18)
Query Neighborhood Hits	66	Target Neighborhood Hits	27	Shared Neighborhood Hits	9
SwissProt Accessions	Q5H8A4, Q2TAK5, Q6UX31, Q7L5Y4, Q8N866, Q8NCC9, Q96SY9, Q9BVT7, Q9NXG5	Gene names	PIGG, GPI7
Domain Architecture	No domain graphic available
Description	GPI ethanolamine phosphate transferase 2 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class G protein) (PIG-G) (GPI7 homolog) (hGPI7).

PIGN_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.052963 (rank : 26)
Query Neighborhood Hits	66	Target Neighborhood Hits	19	Shared Neighborhood Hits	7
SwissProt Accessions	O95427, Q7L8F8, Q8TC01, Q9NT05	Gene names	PIGN, MCD4
Domain Architecture	No domain graphic available
Description	GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class N protein) (PIG-N) (MCD4 homolog).

PIGN_MOUSE
θ value	θ > 10 (rank : 70)	NC score	0.061669 (rank : 23)
Query Neighborhood Hits	66	Target Neighborhood Hits	29	Shared Neighborhood Hits	7
SwissProt Accessions	Q9R1S3, Q3V0S6, Q8VCC3, Q9R1S1, Q9R1S2	Gene names	Pign
Domain Architecture	No domain graphic available
Description	GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class N protein) (PIG-N).

Hits sorted by NC score

ENPP2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 4)
Query Neighborhood Hits	66	Target Neighborhood Hits	66	Shared Neighborhood Hits	66
SwissProt Accessions	Q9R1E6, Q99LG9	Gene names	Enpp2, Npps2
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2) (Phosphodiesterase I/nucleotide pyrophosphatase 2) (Phosphodiesterase I alpha) (PD-Ialpha) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP2_HUMAN
NC score	0.997442 (rank : 2)	θ value	0 (rank : 3)
Query Neighborhood Hits	66	Target Neighborhood Hits	61	Shared Neighborhood Hits	50
SwissProt Accessions	Q13822, Q13827, Q15117	Gene names	ENPP2, ATX, PDNP2
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 2 (E-NPP 2) (Phosphodiesterase I/nucleotide pyrophosphatase 2) (Phosphodiesterase I alpha) (PD-Ialpha) (Autotaxin) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP3_HUMAN
NC score	0.977117 (rank : 3)	θ value	0 (rank : 5)
Query Neighborhood Hits	66	Target Neighborhood Hits	34	Shared Neighborhood Hits	19
SwissProt Accessions	O14638	Gene names	ENPP3, PDNP3
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 3 (E-NPP 3) (Phosphodiesterase I/nucleotide pyrophosphatase 3) (Phosphodiesterase I beta) (PD-Ibeta) (CD203c antigen) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP1_HUMAN
NC score	0.975756 (rank : 4)	θ value	0 (rank : 1)
Query Neighborhood Hits	66	Target Neighborhood Hits	47	Shared Neighborhood Hits	28
SwissProt Accessions	P22413, Q5T9R6, Q9NPZ3, Q9P1P6, Q9UP61, Q9Y6K3	Gene names	ENPP1, NPPS, PC1, PDNP1
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP1_MOUSE
NC score	0.974011 (rank : 5)	θ value	0 (rank : 2)
Query Neighborhood Hits	66	Target Neighborhood Hits	65	Shared Neighborhood Hits	30
SwissProt Accessions	P06802	Gene names	Enpp1, Npps, Pc1, Pdnp1
Domain Architecture
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 1 (E-NPP 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) (Antigen Ly-41) [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (EC 3.6.1.9) (NPPase)].

ENPP7_HUMAN
NC score	0.875613 (rank : 6)	θ value	9.81109e-47 (rank : 8)
Query Neighborhood Hits	66	Target Neighborhood Hits	30	Shared Neighborhood Hits	14
SwissProt Accessions	Q6UWV6, Q6ZTS5, Q8IUS8	Gene names	ENPP7
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 7 precursor (EC 3.1.4.12) (E-NPP7) (NPP-7) (Alkaline sphingomyelin phosphodiesterase) (Intestinal alkaline sphingomyelinase) (Alk-SMase).

ENPP5_HUMAN
NC score	0.867380 (rank : 7)	θ value	1.788e-48 (rank : 7)
Query Neighborhood Hits	66	Target Neighborhood Hits	16	Shared Neighborhood Hits	12
SwissProt Accessions	Q9UJA9, Q6UX49	Gene names	ENPP5
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 5 precursor (EC 3.1.-.-) (E-NPP5) (NPP-5).

ENPP5_MOUSE
NC score	0.867167 (rank : 8)	θ value	8.02596e-49 (rank : 6)
Query Neighborhood Hits	66	Target Neighborhood Hits	14	Shared Neighborhood Hits	12
SwissProt Accessions	Q9EQG7, Q921P7	Gene names	Enpp5
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 5 precursor (EC 3.1.-.-) (E-NPP5) (NPP-5).

ENPP6_HUMAN
NC score	0.852961 (rank : 9)	θ value	5.38352e-45 (rank : 10)
Query Neighborhood Hits	66	Target Neighborhood Hits	17	Shared Neighborhood Hits	12
SwissProt Accessions	Q6UWR7, Q96M57	Gene names	ENPP6
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 6 precursor (EC 3.1.-.-) (E-NPP6) (NPP-6) [Contains: Ectonucleotide pyrophosphatase/phosphodiesterase 6 soluble form].

ENPP6_MOUSE
NC score	0.852084 (rank : 10)	θ value	3.15612e-45 (rank : 9)
Query Neighborhood Hits	66	Target Neighborhood Hits	16	Shared Neighborhood Hits	12
SwissProt Accessions	Q8BGN3, Q4VAH5	Gene names	Enpp6
Domain Architecture	No domain graphic available
Description	Ectonucleotide pyrophosphatase/phosphodiesterase 6 precursor (EC 3.1.-.-) (E-NPP6) (NPP-6) [Contains: Ectonucleotide pyrophosphatase/phosphodiesterase 6 soluble form].

PP11_HUMAN
NC score	0.300217 (rank : 11)	θ value	0.00298849 (rank : 15)
Query Neighborhood Hits	66	Target Neighborhood Hits	20	Shared Neighborhood Hits	12
SwissProt Accessions	P21128, Q2NKJ4	Gene names
Domain Architecture
Description	Placental protein 11 precursor (EC 3.4.21.-) (PP11).

PRG4_MOUSE
NC score	0.202400 (rank : 12)	θ value	3.08544e-08 (rank : 11)
Query Neighborhood Hits	66	Target Neighborhood Hits	624	Shared Neighborhood Hits	20
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

PRG4_HUMAN
NC score	0.179723 (rank : 13)	θ value	7.59969e-07 (rank : 12)
Query Neighborhood Hits	66	Target Neighborhood Hits	764	Shared Neighborhood Hits	17
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

VTNC_MOUSE
NC score	0.165536 (rank : 14)	θ value	0.00102713 (rank : 14)
Query Neighborhood Hits	66	Target Neighborhood Hits	74	Shared Neighborhood Hits	11
SwissProt Accessions	P29788, Q8VII4	Gene names	Vtn
Domain Architecture
Description	Vitronectin precursor (Serum-spreading factor) (S-protein).

PIGO_HUMAN
NC score	0.165290 (rank : 15)	θ value	0.0113563 (rank : 17)
Query Neighborhood Hits	66	Target Neighborhood Hits	24	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TEQ8, Q6P154, Q6UX80, Q8TDS8, Q96CS9, Q9BVN9, Q9Y4B0	Gene names	PIGO
Domain Architecture
Description	GPI ethanolamine phosphate transferase 3 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class O protein) (PIG-O).

PIGO_MOUSE
NC score	0.159368 (rank : 16)	θ value	0.0113563 (rank : 18)
Query Neighborhood Hits	66	Target Neighborhood Hits	21	Shared Neighborhood Hits	11
SwissProt Accessions	Q9JJI6, Q9CRY2	Gene names	Pigo
Domain Architecture
Description	GPI ethanolamine phosphate transferase 3 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class O protein) (PIG-O).

VTNC_HUMAN
NC score	0.158851 (rank : 17)	θ value	0.00102713 (rank : 13)
Query Neighborhood Hits	66	Target Neighborhood Hits	66	Shared Neighborhood Hits	12
SwissProt Accessions	P04004, P01141, Q9BSH7	Gene names	VTN
Domain Architecture
Description	Vitronectin precursor (Serum-spreading factor) (S-protein) (V75) [Contains: Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin B].

PIGG_HUMAN
NC score	0.131506 (rank : 18)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	66	Target Neighborhood Hits	27	Shared Neighborhood Hits	9
SwissProt Accessions	Q5H8A4, Q2TAK5, Q6UX31, Q7L5Y4, Q8N866, Q8NCC9, Q96SY9, Q9BVT7, Q9NXG5	Gene names	PIGG, GPI7
Domain Architecture	No domain graphic available
Description	GPI ethanolamine phosphate transferase 2 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class G protein) (PIG-G) (GPI7 homolog) (hGPI7).

SUSD2_HUMAN
NC score	0.099604 (rank : 19)	θ value	0.279714 (rank : 29)
Query Neighborhood Hits	66	Target Neighborhood Hits	99	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UGT4, Q9H5Y6	Gene names	SUSD2
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 2 precursor.

TINAG_HUMAN
NC score	0.083087 (rank : 20)	θ value	0.47712 (rank : 34)
Query Neighborhood Hits	66	Target Neighborhood Hits	63	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UJW2, Q9UJW1, Q9ULZ4	Gene names	TINAG
Domain Architecture
Description	Tubulointerstitial nephritis antigen (TIN-Ag).

SUSD2_MOUSE
NC score	0.083021 (rank : 21)	θ value	1.38821 (rank : 41)
Query Neighborhood Hits	66	Target Neighborhood Hits	104	Shared Neighborhood Hits	15
SwissProt Accessions	Q9DBX3, Q8BY19, Q8BYN0, Q8BYZ3, Q8BYZ9, Q8BZQ4, Q8C179	Gene names	Susd2
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 2 precursor.

KRA59_HUMAN
NC score	0.080379 (rank : 22)	θ value	0.0193708 (rank : 19)
Query Neighborhood Hits	66	Target Neighborhood Hits	310	Shared Neighborhood Hits	32
SwissProt Accessions	P26371, Q14564	Gene names	KRTAP5-9, KAP5.9, KRN1, KRTAP5.9, UHSK1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-9 (Keratin-associated protein 5.9) (Ultrahigh sulfur keratin-associated protein 5.9) (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (UHS keratin A) (UHS KerA).

PIGN_MOUSE
NC score	0.061669 (rank : 23)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	66	Target Neighborhood Hits	29	Shared Neighborhood Hits	7
SwissProt Accessions	Q9R1S3, Q3V0S6, Q8VCC3, Q9R1S1, Q9R1S2	Gene names	Pign
Domain Architecture	No domain graphic available
Description	GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class N protein) (PIG-N).

KRA58_HUMAN
NC score	0.058485 (rank : 24)	θ value	1.38821 (rank : 39)
Query Neighborhood Hits	66	Target Neighborhood Hits	324	Shared Neighborhood Hits	31
SwissProt Accessions	O75690, Q6L8G7, Q6UTX6	Gene names	KRTAP5-8, KAP5.8, KRTAP5.8, UHSKB
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-8 (Keratin-associated protein 5.8) (Ultrahigh sulfur keratin-associated protein 5.8) (Keratin, ultra high-sulfur matrix protein B) (UHS keratin B) (UHS KerB).

KRA54_HUMAN
NC score	0.055659 (rank : 25)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	66	Target Neighborhood Hits	270	Shared Neighborhood Hits	30
SwissProt Accessions	Q6L8H1	Gene names	KRTAP5-4, KAP5.4, KRTAP5.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-4 (Keratin-associated protein 5.4) (Ultrahigh sulfur keratin-associated protein 5.4).

PIGN_HUMAN
NC score	0.052963 (rank : 26)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	66	Target Neighborhood Hits	19	Shared Neighborhood Hits	7
SwissProt Accessions	O95427, Q7L8F8, Q8TC01, Q9NT05	Gene names	PIGN, MCD4
Domain Architecture	No domain graphic available
Description	GPI ethanolamine phosphate transferase 1 (EC 2.-.-.-) (Phosphatidylinositol-glycan biosynthesis class N protein) (PIG-N) (MCD4 homolog).

LTBP2_HUMAN
NC score	0.051775 (rank : 27)	θ value	0.00509761 (rank : 16)
Query Neighborhood Hits	66	Target Neighborhood Hits	552	Shared Neighborhood Hits	35
SwissProt Accessions	Q14767, Q99907, Q9NS51	Gene names	LTBP2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

ARSA_HUMAN
NC score	0.051361 (rank : 28)	θ value	0.0961366 (rank : 22)
Query Neighborhood Hits	66	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	P15289, Q6ICI5, Q96CJ0	Gene names	ARSA
Domain Architecture
Description	Arylsulfatase A precursor (EC 3.1.6.8) (ASA) (Cerebroside-sulfatase) [Contains: Arylsulfatase A component B; Arylsulfatase A component C].

KRA53_HUMAN
NC score	0.049337 (rank : 29)	θ value	1.38821 (rank : 38)
Query Neighborhood Hits	66	Target Neighborhood Hits	331	Shared Neighborhood Hits	31
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

TENA_MOUSE
NC score	0.048490 (rank : 30)	θ value	0.0193708 (rank : 20)
Query Neighborhood Hits	66	Target Neighborhood Hits	596	Shared Neighborhood Hits	35
SwissProt Accessions	Q80YX1, Q64706, Q80YX2	Gene names	Tnc, Hxb
Domain Architecture	No domain graphic available
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion).

TENA_HUMAN
NC score	0.047347 (rank : 31)	θ value	0.163984 (rank : 25)
Query Neighborhood Hits	66	Target Neighborhood Hits	631	Shared Neighborhood Hits	37
SwissProt Accessions	P24821, Q14583, Q15567	Gene names	TNC, HXB
Domain Architecture
Description	Tenascin precursor (TN) (Tenascin-C) (TN-C) (Hexabrachion) (Cytotactin) (Neuronectin) (GMEM) (JI) (Myotendinous antigen) (Glioma- associated-extracellular matrix antigen) (GP 150-225).

LTBP2_MOUSE
NC score	0.047185 (rank : 32)	θ value	0.125558 (rank : 24)
Query Neighborhood Hits	66	Target Neighborhood Hits	617	Shared Neighborhood Hits	36
SwissProt Accessions	O08999, Q8C6W9	Gene names	Ltbp2
Domain Architecture
Description	Latent-transforming growth factor beta-binding protein 2 precursor (LTBP-2).

KRA57_HUMAN
NC score	0.046191 (rank : 33)	θ value	6.88961 (rank : 56)
Query Neighborhood Hits	66	Target Neighborhood Hits	269	Shared Neighborhood Hits	29
SwissProt Accessions	Q6L8G8, Q701N5	Gene names	KRTAP5-7, KAP5-7, KAP5.3, KRTAP5.3, KRTAP5.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-7 (Keratin-associated protein 5.7) (Ultrahigh sulfur keratin-associated protein 5.7) (Keratin-associated protein 5-3) (Keratin-associated protein 5.3).

TENR_HUMAN
NC score	0.045526 (rank : 34)	θ value	0.365318 (rank : 32)
Query Neighborhood Hits	66	Target Neighborhood Hits	526	Shared Neighborhood Hits	34
SwissProt Accessions	Q92752, Q15568, Q5R3G0	Gene names	TNR
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin).

TENR_MOUSE
NC score	0.043960 (rank : 35)	θ value	0.365318 (rank : 33)
Query Neighborhood Hits	66	Target Neighborhood Hits	531	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BYI9, O88717	Gene names	Tnr
Domain Architecture	No domain graphic available
Description	Tenascin-R precursor (TN-R) (Restrictin) (Janusin) (Neural recognition molecule J1-160/180).

GRN_HUMAN
NC score	0.043734 (rank : 36)	θ value	6.88961 (rank : 55)
Query Neighborhood Hits	66	Target Neighborhood Hits	268	Shared Neighborhood Hits	31
SwissProt Accessions	P28799, P23781, P23782, P23783, P23784, Q9BWE7, Q9UCH0	Gene names	GRN
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin; Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)].

FBN2_HUMAN
NC score	0.043353 (rank : 37)	θ value	0.279714 (rank : 27)
Query Neighborhood Hits	66	Target Neighborhood Hits	560	Shared Neighborhood Hits	36
SwissProt Accessions	P35556	Gene names	FBN2
Domain Architecture
Description	Fibrillin-2 precursor.

CNBP_MOUSE
NC score	0.041400 (rank : 38)	θ value	1.06291 (rank : 36)
Query Neighborhood Hits	66	Target Neighborhood Hits	215	Shared Neighborhood Hits	3
SwissProt Accessions	P53996, Q80Y06, Q8BP23	Gene names	Cnbp, Cnbp1, Znf9
Domain Architecture	No domain graphic available
Description	Cellular nucleic acid-binding protein (CNBP) (Zinc finger protein 9).

MEGF6_HUMAN
NC score	0.040433 (rank : 39)	θ value	0.365318 (rank : 31)
Query Neighborhood Hits	66	Target Neighborhood Hits	671	Shared Neighborhood Hits	34
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

ARSA_MOUSE
NC score	0.040396 (rank : 40)	θ value	0.62314 (rank : 35)
Query Neighborhood Hits	66	Target Neighborhood Hits	30	Shared Neighborhood Hits	6
SwissProt Accessions	P50428	Gene names	Arsa, As2
Domain Architecture
Description	Arylsulfatase A precursor (EC 3.1.6.8) (ASA) (Cerebroside-sulfatase).

FBN2_MOUSE
NC score	0.040391 (rank : 41)	θ value	1.81305 (rank : 42)
Query Neighborhood Hits	66	Target Neighborhood Hits	549	Shared Neighborhood Hits	37
SwissProt Accessions	Q61555, Q63957	Gene names	Fbn2, Fbn-2
Domain Architecture
Description	Fibrillin-2 precursor.

LRP1B_HUMAN
NC score	0.040280 (rank : 42)	θ value	0.365318 (rank : 30)
Query Neighborhood Hits	66	Target Neighborhood Hits	602	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

TENX_HUMAN
NC score	0.039650 (rank : 43)	θ value	2.36792 (rank : 43)
Query Neighborhood Hits	66	Target Neighborhood Hits	789	Shared Neighborhood Hits	35
SwissProt Accessions	P22105, P78530, P78531, Q08424, Q9UMG7	Gene names	TNXB, HXBL, TNX, XB
Domain Architecture
Description	Tenascin-X precursor (TN-X) (Hexabrachion-like protein).

FBN1_HUMAN
NC score	0.039359 (rank : 44)	θ value	8.99809 (rank : 62)
Query Neighborhood Hits	66	Target Neighborhood Hits	557	Shared Neighborhood Hits	37
SwissProt Accessions	P35555, Q15972, Q75N87	Gene names	FBN1, FBN
Domain Architecture
Description	Fibrillin-1 precursor.

LRP2_HUMAN
NC score	0.037553 (rank : 45)	θ value	1.38821 (rank : 40)
Query Neighborhood Hits	66	Target Neighborhood Hits	573	Shared Neighborhood Hits	39
SwissProt Accessions	P98164, O00711, Q16215	Gene names	LRP2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 2 precursor (Megalin) (Glycoprotein 330) (gp330).

NOTC4_MOUSE
NC score	0.036301 (rank : 46)	θ value	0.0563607 (rank : 21)
Query Neighborhood Hits	66	Target Neighborhood Hits	872	Shared Neighborhood Hits	37
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

FBN3_HUMAN
NC score	0.036128 (rank : 47)	θ value	4.03905 (rank : 47)
Query Neighborhood Hits	66	Target Neighborhood Hits	543	Shared Neighborhood Hits	34
SwissProt Accessions	Q75N90, Q75N91, Q75N92, Q75N93, Q86SJ5, Q96JP8	Gene names	FBN3, KIAA1776
Domain Architecture	No domain graphic available
Description	Fibrillin-3 precursor.

KRA51_HUMAN
NC score	0.035784 (rank : 48)	θ value	8.99809 (rank : 63)
Query Neighborhood Hits	66	Target Neighborhood Hits	288	Shared Neighborhood Hits	27
SwissProt Accessions	Q6L8H4	Gene names	KRTAP5-1, KAP5.1, KRTAP5.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-1 (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1).

TENN_HUMAN
NC score	0.035323 (rank : 49)	θ value	3.0926 (rank : 45)
Query Neighborhood Hits	66	Target Neighborhood Hits	453	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UQP3, Q5R360	Gene names	TNN
Domain Architecture
Description	Tenascin-N precursor (TN-N).

TECTA_MOUSE
NC score	0.033545 (rank : 50)	θ value	0.21417 (rank : 26)
Query Neighborhood Hits	66	Target Neighborhood Hits	244	Shared Neighborhood Hits	27
SwissProt Accessions	O08523	Gene names	Tecta
Domain Architecture
Description	Alpha-tectorin precursor.

LRP1_HUMAN
NC score	0.032652 (rank : 51)	θ value	4.03905 (rank : 48)
Query Neighborhood Hits	66	Target Neighborhood Hits	617	Shared Neighborhood Hits	37
SwissProt Accessions	Q07954, Q2PP12, Q8IVG8	Gene names	LRP1, A2MR
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1 precursor (LRP) (Alpha-2-macroglobulin receptor) (A2MR) (Apolipoprotein E receptor) (APOER) (CD91 antigen).

NOTC2_MOUSE
NC score	0.032097 (rank : 52)	θ value	4.03905 (rank : 49)
Query Neighborhood Hits	66	Target Neighborhood Hits	1069	Shared Neighborhood Hits	40
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

SCUB3_MOUSE
NC score	0.031470 (rank : 53)	θ value	8.99809 (rank : 65)
Query Neighborhood Hits	66	Target Neighborhood Hits	442	Shared Neighborhood Hits	31
SwissProt Accessions	Q66PY1, Q68FG9	Gene names	Scube3
Domain Architecture	No domain graphic available
Description	Signal peptide, CUB and EGF-like domain-containing protein 3 precursor.

NOTC4_HUMAN
NC score	0.030671 (rank : 54)	θ value	8.99809 (rank : 64)
Query Neighborhood Hits	66	Target Neighborhood Hits	905	Shared Neighborhood Hits	34
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

FSTL5_HUMAN
NC score	0.029745 (rank : 55)	θ value	0.279714 (rank : 28)
Query Neighborhood Hits	66	Target Neighborhood Hits	347	Shared Neighborhood Hits	8
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

ARSF_HUMAN
NC score	0.029261 (rank : 56)	θ value	4.03905 (rank : 46)
Query Neighborhood Hits	66	Target Neighborhood Hits	33	Shared Neighborhood Hits	8
SwissProt Accessions	P54793, Q8TCC5	Gene names	ARSF
Domain Architecture
Description	Arylsulfatase F precursor (EC 3.1.6.-) (ASF).

WFDC8_HUMAN
NC score	0.029104 (rank : 57)	θ value	4.03905 (rank : 50)
Query Neighborhood Hits	66	Target Neighborhood Hits	82	Shared Neighborhood Hits	9
SwissProt Accessions	Q8IUA0, Q5TDV2, Q96A34	Gene names	WFDC8, C20orf170, WAP8
Domain Architecture
Description	WAP four-disulfide core domain protein 8 precursor (Putative protease inhibitor WAP8).

AGRIN_HUMAN
NC score	0.028858 (rank : 58)	θ value	8.99809 (rank : 60)
Query Neighborhood Hits	66	Target Neighborhood Hits	582	Shared Neighborhood Hits	38
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

STS_MOUSE
NC score	0.028335 (rank : 59)	θ value	5.27518 (rank : 51)
Query Neighborhood Hits	66	Target Neighborhood Hits	38	Shared Neighborhood Hits	8
SwissProt Accessions	P50427	Gene names	Sts
Domain Architecture
Description	Steryl-sulfatase precursor (EC 3.1.6.2) (Steroid sulfatase) (Steryl- sulfate sulfohydrolase) (Arylsulfatase C) (ASC).

ADA28_HUMAN
NC score	0.026614 (rank : 60)	θ value	0.125558 (rank : 23)
Query Neighborhood Hits	66	Target Neighborhood Hits	244	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UKQ2, Q9Y339, Q9Y3S0	Gene names	ADAM28, MDCL
Domain Architecture
Description	ADAM 28 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 28) (Metalloproteinase-like, disintegrin-like, and cysteine- rich protein-L) (MDC-L) (eMDC II) (ADAM23).

FSTL4_HUMAN
NC score	0.026130 (rank : 61)	θ value	1.38821 (rank : 37)
Query Neighborhood Hits	66	Target Neighborhood Hits	344	Shared Neighborhood Hits	13
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

FSTL4_MOUSE
NC score	0.024949 (rank : 62)	θ value	3.0926 (rank : 44)
Query Neighborhood Hits	66	Target Neighborhood Hits	333	Shared Neighborhood Hits	10
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

FRAS1_HUMAN
NC score	0.022544 (rank : 63)	θ value	6.88961 (rank : 54)
Query Neighborhood Hits	66	Target Neighborhood Hits	759	Shared Neighborhood Hits	33
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

TINAL_MOUSE
NC score	0.016982 (rank : 64)	θ value	6.88961 (rank : 58)
Query Neighborhood Hits	66	Target Neighborhood Hits	52	Shared Neighborhood Hits	9
SwissProt Accessions	Q99JR5, Q9EQT9	Gene names	Tinagl1, Arg1, Lcn7, Tinagl
Domain Architecture	No domain graphic available
Description	Tubulointerstitial nephritis antigen-like precursor (Androgen- regulated gene 1 protein) (Adrenocortical zonation factor 1) (AZ-1) (Tubulointerstitial nephritis antigen-related protein) (TARP).

ADA28_MOUSE
NC score	0.016378 (rank : 65)	θ value	8.99809 (rank : 59)
Query Neighborhood Hits	66	Target Neighborhood Hits	241	Shared Neighborhood Hits	29
SwissProt Accessions	Q9JLN6, Q8K5D2, Q8K5D3	Gene names	Adam28
Domain Architecture
Description	ADAM 28 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase domain 28) (Thymic epithelial cell-ADAM) (TECADAM).

ADAM2_HUMAN
NC score	0.016205 (rank : 66)	θ value	6.88961 (rank : 52)
Query Neighborhood Hits	66	Target Neighborhood Hits	175	Shared Neighborhood Hits	25
SwissProt Accessions	Q99965, P78326, Q9UQQ8	Gene names	ADAM2, FTNB
Domain Architecture
Description	ADAM 2 precursor (A disintegrin and metalloproteinase domain 2) (Fertilin subunit beta) (PH-30) (PH30).

PGBM_MOUSE
NC score	0.013107 (rank : 67)	θ value	6.88961 (rank : 57)
Query Neighborhood Hits	66	Target Neighborhood Hits	1073	Shared Neighborhood Hits	34
SwissProt Accessions	Q05793	Gene names	Hspg2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

AS3MT_HUMAN
NC score	0.009580 (rank : 68)	θ value	8.99809 (rank : 61)
Query Neighborhood Hits	66	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q9HBK9	Gene names	AS3MT, CYT19
Domain Architecture	No domain graphic available
Description	Arsenite methyltransferase (EC 2.1.1.137) (S-adenosyl-L- methionine:arsenic(III) methyltransferase) (Methylarsonite methyltransferase).

SEZ6L_HUMAN
NC score	0.006426 (rank : 69)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	66	Target Neighborhood Hits	289	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BYH1, O95917, Q5THY5, Q6IBZ4, Q6UXD4, Q9NUI3, Q9NUI4, Q9NUI5, Q9Y2E1, Q9Y3J6	Gene names	SEZ6L, KIAA0927
Domain Architecture
Description	Seizure 6-like protein precursor.

CFAI_MOUSE
NC score	0.005679 (rank : 70)	θ value	6.88961 (rank : 53)
Query Neighborhood Hits	66	Target Neighborhood Hits	290	Shared Neighborhood Hits	18
SwissProt Accessions	Q61129, Q9WU07	Gene names	Cfi, If
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].