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Network neighborhood for query Sequence : WISP3_HUMAN

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WISP3_HUMAN
SwissProt Accessions	O95389, Q6UXH6	Gene names	WISP3, CCN6
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 3 precursor (WISP-3).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

WISP3_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	87	Target Neighborhood Hits	87	Shared Neighborhood Hits	87
SwissProt Accessions	O95389, Q6UXH6	Gene names	WISP3, CCN6
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 3 precursor (WISP-3).

WISP1_HUMAN
θ value	5.50685e-82 (rank : 2)	NC score	0.960646 (rank : 2)
Query Neighborhood Hits	87	Target Neighborhood Hits	121	Shared Neighborhood Hits	69
SwissProt Accessions	O95388, Q9HCS3	Gene names	WISP1, CCN4
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (Wnt-1- induced secreted protein).

WISP1_MOUSE
θ value	1.14825e-79 (rank : 3)	NC score	0.956399 (rank : 3)
Query Neighborhood Hits	87	Target Neighborhood Hits	123	Shared Neighborhood Hits	74
SwissProt Accessions	O54775, Q80ZL1	Gene names	Wisp1, Ccn4, Elm1
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (ELM-1).

CTGF_HUMAN
θ value	1.7756e-72 (rank : 4)	NC score	0.946488 (rank : 5)
Query Neighborhood Hits	87	Target Neighborhood Hits	128	Shared Neighborhood Hits	72
SwissProt Accessions	P29279, Q96QX2	Gene names	CTGF, CCN2, HCS24
Domain Architecture
Description	Connective tissue growth factor precursor (Hypertrophic chondrocyte- specific protein 24).

CTGF_MOUSE
θ value	5.53243e-66 (rank : 5)	NC score	0.950069 (rank : 4)
Query Neighborhood Hits	87	Target Neighborhood Hits	124	Shared Neighborhood Hits	74
SwissProt Accessions	P29268, Q922U0	Gene names	Ctgf, Ccn2, Fisp-12, Fisp12, Hcs24
Domain Architecture
Description	Connective tissue growth factor precursor (Protein FISP-12) (Hypertrophic chondrocyte-specific protein 24).

NOV_MOUSE
θ value	9.45883e-58 (rank : 6)	NC score	0.943761 (rank : 6)
Query Neighborhood Hits	87	Target Neighborhood Hits	130	Shared Neighborhood Hits	72
SwissProt Accessions	Q64299, Q8CA67	Gene names	Nov, Ccn3
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

NOV_HUMAN
θ value	3.0428e-56 (rank : 7)	NC score	0.936542 (rank : 7)
Query Neighborhood Hits	87	Target Neighborhood Hits	128	Shared Neighborhood Hits	69
SwissProt Accessions	P48745, Q96BY5	Gene names	NOV, CCN3, IGFBP9, NOVH
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

CYR61_MOUSE
θ value	4.39379e-55 (rank : 8)	NC score	0.933422 (rank : 9)
Query Neighborhood Hits	87	Target Neighborhood Hits	156	Shared Neighborhood Hits	74
SwissProt Accessions	P18406	Gene names	Cyr61, Ccn1, Igfbp10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (3CH61).

CYR61_HUMAN
θ value	1.66964e-54 (rank : 9)	NC score	0.933601 (rank : 8)
Query Neighborhood Hits	87	Target Neighborhood Hits	159	Shared Neighborhood Hits	77
SwissProt Accessions	O00622, O14934, O43775, Q9BZL7	Gene names	CYR61, CCN1, GIG1, IGFBP10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (Protein GIG1).

WISP2_MOUSE
θ value	2.51237e-26 (rank : 10)	NC score	0.888259 (rank : 11)
Query Neighborhood Hits	87	Target Neighborhood Hits	129	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Z0G4, Q8CIC8	Gene names	Wisp2, Ccn5, Ctgfl
Domain Architecture
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L).

WISP2_HUMAN
θ value	2.59989e-23 (rank : 11)	NC score	0.893546 (rank : 10)
Query Neighborhood Hits	87	Target Neighborhood Hits	126	Shared Neighborhood Hits	73
SwissProt Accessions	O76076	Gene names	WISP2, CCN5, CT58, CTGFL
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L) (Connective tissue growth factor-related protein 58).

VWF_HUMAN
θ value	0.000158464 (rank : 12)	NC score	0.147884 (rank : 35)
Query Neighborhood Hits	87	Target Neighborhood Hits	396	Shared Neighborhood Hits	40
SwissProt Accessions	P04275	Gene names	VWF, F8VWF
Domain Architecture
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

CRIM1_HUMAN
θ value	0.00134147 (rank : 13)	NC score	0.220155 (rank : 20)
Query Neighborhood Hits	87	Target Neighborhood Hits	362	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

SSPO_MOUSE
θ value	0.00298849 (rank : 14)	NC score	0.172804 (rank : 27)
Query Neighborhood Hits	87	Target Neighborhood Hits	800	Shared Neighborhood Hits	69
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

ATS1_MOUSE
θ value	0.00869519 (rank : 15)	NC score	0.134020 (rank : 44)
Query Neighborhood Hits	87	Target Neighborhood Hits	158	Shared Neighborhood Hits	47
SwissProt Accessions	P97857, O54768	Gene names	Adamts1
Domain Architecture
Description	ADAMTS-1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 1) (ADAM-TS 1) (ADAM-TS1).

HTRA1_HUMAN
θ value	0.00869519 (rank : 16)	NC score	0.229730 (rank : 16)
Query Neighborhood Hits	87	Target Neighborhood Hits	155	Shared Neighborhood Hits	33
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

TSP1_MOUSE
θ value	0.00869519 (rank : 17)	NC score	0.138707 (rank : 42)
Query Neighborhood Hits	87	Target Neighborhood Hits	396	Shared Neighborhood Hits	61
SwissProt Accessions	P35441	Gene names	Thbs1, Tsp1
Domain Architecture
Description	Thrombospondin-1 precursor.

VWF_MOUSE
θ value	0.00869519 (rank : 18)	NC score	0.147531 (rank : 37)
Query Neighborhood Hits	87	Target Neighborhood Hits	381	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CIZ8, Q60863, Q6XUV6, Q8BIU9, Q8CGN0, Q9JK16	Gene names	Vwf
Domain Architecture	No domain graphic available
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

ATS19_HUMAN
θ value	0.0113563 (rank : 19)	NC score	0.131351 (rank : 47)
Query Neighborhood Hits	87	Target Neighborhood Hits	203	Shared Neighborhood Hits	45
SwissProt Accessions	Q8TE59	Gene names	ADAMTS19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

HTRA3_HUMAN
θ value	0.0113563 (rank : 20)	NC score	0.219968 (rank : 21)
Query Neighborhood Hits	87	Target Neighborhood Hits	152	Shared Neighborhood Hits	31
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

HTRA3_MOUSE
θ value	0.0113563 (rank : 21)	NC score	0.221777 (rank : 18)
Query Neighborhood Hits	87	Target Neighborhood Hits	156	Shared Neighborhood Hits	33
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

TSP1_HUMAN
θ value	0.0148317 (rank : 22)	NC score	0.140919 (rank : 41)
Query Neighborhood Hits	87	Target Neighborhood Hits	389	Shared Neighborhood Hits	61
SwissProt Accessions	P07996, Q15667	Gene names	THBS1, TSP, TSP1
Domain Architecture
Description	Thrombospondin-1 precursor.

ATS19_MOUSE
θ value	0.0330416 (rank : 23)	NC score	0.132471 (rank : 45)
Query Neighborhood Hits	87	Target Neighborhood Hits	188	Shared Neighborhood Hits	46
SwissProt Accessions	P59509	Gene names	Adamts19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

ESM1_MOUSE
θ value	0.0330416 (rank : 24)	NC score	0.324619 (rank : 12)
Query Neighborhood Hits	87	Target Neighborhood Hits	107	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QYY7	Gene names	Esm1
Domain Architecture
Description	Endothelial cell-specific molecule 1 precursor (ESM-1 secretory protein) (ESM-1).

IBP2_HUMAN
θ value	0.0563607 (rank : 25)	NC score	0.176588 (rank : 25)
Query Neighborhood Hits	87	Target Neighborhood Hits	61	Shared Neighborhood Hits	30
SwissProt Accessions	P18065, Q14619, Q9UCL3	Gene names	IGFBP2, BP2
Domain Architecture
Description	Insulin-like growth factor-binding protein 2 precursor (IGFBP-2) (IBP- 2) (IGF-binding protein 2).

HTRA4_HUMAN
θ value	0.0736092 (rank : 26)	NC score	0.248787 (rank : 14)
Query Neighborhood Hits	87	Target Neighborhood Hits	119	Shared Neighborhood Hits	31
SwissProt Accessions	P83105, Q542Z4, Q6PF13	Gene names	HTRA4
Domain Architecture	No domain graphic available
Description	Probable serine protease HTRA4 precursor (EC 3.4.21.-).

IBP2_MOUSE
θ value	0.0736092 (rank : 27)	NC score	0.195053 (rank : 22)
Query Neighborhood Hits	87	Target Neighborhood Hits	65	Shared Neighborhood Hits	30
SwissProt Accessions	P47877, Q61722	Gene names	Igfbp2, Igfbp-2
Domain Architecture
Description	Insulin-like growth factor-binding protein 2 precursor (IGFBP-2) (IBP- 2) (IGF-binding protein 2).

SPON1_HUMAN
θ value	0.0736092 (rank : 28)	NC score	0.169506 (rank : 28)
Query Neighborhood Hits	87	Target Neighborhood Hits	117	Shared Neighborhood Hits	47
SwissProt Accessions	Q9HCB6, O94862, Q8NCD7, Q8WUR5	Gene names	SPON1, KIAA0762, VSGP
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin) (Vascular smooth muscle cell growth- promoting factor).

ATS1_HUMAN
θ value	0.0961366 (rank : 29)	NC score	0.124104 (rank : 50)
Query Neighborhood Hits	87	Target Neighborhood Hits	159	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UHI8, Q9NSJ8, Q9P2K0, Q9UH83, Q9UP80	Gene names	ADAMTS1, KIAA1346, METH1
Domain Architecture
Description	ADAMTS-1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 1) (ADAM-TS 1) (ADAM-TS1) (METH-1).

BMPER_MOUSE
θ value	0.0961366 (rank : 30)	NC score	0.234848 (rank : 15)
Query Neighborhood Hits	87	Target Neighborhood Hits	194	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CJ69, Q7TN57, Q80UZ1, Q9CXM8	Gene names	Bmper, Cv2
Domain Architecture
Description	BMP-binding endothelial regulator protein precursor (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (mCV2).

SPON1_MOUSE
θ value	0.0961366 (rank : 31)	NC score	0.166607 (rank : 30)
Query Neighborhood Hits	87	Target Neighborhood Hits	123	Shared Neighborhood Hits	46
SwissProt Accessions	Q8VCC9, Q8K2Q8	Gene names	Spon1
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin).

IBP7_MOUSE
θ value	0.163984 (rank : 32)	NC score	0.189210 (rank : 23)
Query Neighborhood Hits	87	Target Neighborhood Hits	230	Shared Neighborhood Hits	34
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

IBP7_HUMAN
θ value	0.279714 (rank : 33)	NC score	0.175673 (rank : 26)
Query Neighborhood Hits	87	Target Neighborhood Hits	220	Shared Neighborhood Hits	30
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

KAZD1_MOUSE
θ value	0.279714 (rank : 34)	NC score	0.138378 (rank : 43)
Query Neighborhood Hits	87	Target Neighborhood Hits	281	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

SLIT2_HUMAN
θ value	0.279714 (rank : 35)	NC score	0.052906 (rank : 127)
Query Neighborhood Hits	87	Target Neighborhood Hits	708	Shared Neighborhood Hits	31
SwissProt Accessions	O94813, O95710, Q9Y5Q7	Gene names	SLIT2, SLIL3
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

SLIT2_MOUSE
θ value	0.279714 (rank : 36)	NC score	0.052342 (rank : 129)
Query Neighborhood Hits	87	Target Neighborhood Hits	684	Shared Neighborhood Hits	27
SwissProt Accessions	Q9R1B9, Q9Z166	Gene names	Slit2
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

ZAN_MOUSE
θ value	0.279714 (rank : 37)	NC score	0.111696 (rank : 67)
Query Neighborhood Hits	87	Target Neighborhood Hits	808	Shared Neighborhood Hits	49
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

BMPER_HUMAN
θ value	0.365318 (rank : 38)	NC score	0.227044 (rank : 17)
Query Neighborhood Hits	87	Target Neighborhood Hits	175	Shared Neighborhood Hits	33
SwissProt Accessions	Q8N8U9	Gene names	BMPER
Domain Architecture
Description	BMP-binding endothelial regulator protein precursor (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (hCV2).

HTRA1_MOUSE
θ value	0.365318 (rank : 39)	NC score	0.220588 (rank : 19)
Query Neighborhood Hits	87	Target Neighborhood Hits	140	Shared Neighborhood Hits	31
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

SLIT1_HUMAN
θ value	0.365318 (rank : 40)	NC score	0.032041 (rank : 142)
Query Neighborhood Hits	87	Target Neighborhood Hits	700	Shared Neighborhood Hits	24
SwissProt Accessions	O75093, Q8WWZ2, Q9UIL7	Gene names	SLIT1, KIAA0813, MEGF4, SLIL1
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1) (Multiple epidermal growth factor-like domains 4).

ATS16_HUMAN
θ value	0.47712 (rank : 41)	NC score	0.115409 (rank : 58)
Query Neighborhood Hits	87	Target Neighborhood Hits	208	Shared Neighborhood Hits	45
SwissProt Accessions	Q8TE57, Q8IVE2	Gene names	ADAMTS16, KIAA2029
Domain Architecture
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

IBP5_HUMAN
θ value	0.47712 (rank : 42)	NC score	0.156680 (rank : 34)
Query Neighborhood Hits	87	Target Neighborhood Hits	68	Shared Neighborhood Hits	31
SwissProt Accessions	P24593	Gene names	IGFBP5, IBP5
Domain Architecture
Description	Insulin-like growth factor-binding protein 5 precursor (IGFBP-5) (IBP- 5) (IGF-binding protein 5).

IBP5_MOUSE
θ value	0.47712 (rank : 43)	NC score	0.158437 (rank : 32)
Query Neighborhood Hits	87	Target Neighborhood Hits	68	Shared Neighborhood Hits	31
SwissProt Accessions	Q07079	Gene names	Igfbp5, Igfbp-5
Domain Architecture
Description	Insulin-like growth factor-binding protein 5 precursor (IGFBP-5) (IBP- 5) (IGF-binding protein 5).

ATS12_HUMAN
θ value	0.62314 (rank : 44)	NC score	0.129938 (rank : 48)
Query Neighborhood Hits	87	Target Neighborhood Hits	251	Shared Neighborhood Hits	48
SwissProt Accessions	P58397, Q6UWL3	Gene names	ADAMTS12
Domain Architecture
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

ATS14_HUMAN
θ value	0.62314 (rank : 45)	NC score	0.109450 (rank : 72)
Query Neighborhood Hits	87	Target Neighborhood Hits	382	Shared Neighborhood Hits	47
SwissProt Accessions	Q8WXS8, Q8TE55, Q8TEY8	Gene names	ADAMTS14
Domain Architecture
Description	ADAMTS-14 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 14) (ADAM-TS 14) (ADAM-TS14).

IBP3_HUMAN
θ value	0.62314 (rank : 46)	NC score	0.132289 (rank : 46)
Query Neighborhood Hits	87	Target Neighborhood Hits	67	Shared Neighborhood Hits	29
SwissProt Accessions	P17936, Q2V509, Q6P1M6	Gene names	IGFBP3, IBP3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

ATS16_MOUSE
θ value	0.813845 (rank : 47)	NC score	0.115384 (rank : 59)
Query Neighborhood Hits	87	Target Neighborhood Hits	179	Shared Neighborhood Hits	46
SwissProt Accessions	Q69Z28, Q8K206	Gene names	Adamts16, Kiaa2029
Domain Architecture	No domain graphic available
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

ATS20_MOUSE
θ value	0.813845 (rank : 48)	NC score	0.120476 (rank : 54)
Query Neighborhood Hits	87	Target Neighborhood Hits	225	Shared Neighborhood Hits	48
SwissProt Accessions	P59511	Gene names	Adamts20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

ESM1_HUMAN
θ value	0.813845 (rank : 49)	NC score	0.291986 (rank : 13)
Query Neighborhood Hits	87	Target Neighborhood Hits	110	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NQ30, Q15330, Q96ES3	Gene names	ESM1
Domain Architecture	No domain graphic available
Description	Endothelial cell-specific molecule 1 precursor (ESM-1 secretory protein) (ESM-1).

KAZD1_HUMAN
θ value	0.813845 (rank : 50)	NC score	0.141081 (rank : 40)
Query Neighborhood Hits	87	Target Neighborhood Hits	248	Shared Neighborhood Hits	31
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

NOTC4_MOUSE
θ value	0.813845 (rank : 51)	NC score	0.034380 (rank : 141)
Query Neighborhood Hits	87	Target Neighborhood Hits	872	Shared Neighborhood Hits	34
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

ATL2_HUMAN
θ value	1.06291 (rank : 52)	NC score	0.147780 (rank : 36)
Query Neighborhood Hits	87	Target Neighborhood Hits	125	Shared Neighborhood Hits	45
SwissProt Accessions	Q86TH1, O60345	Gene names	ADAMTSL2, KIAA0605
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2).

ATL2_MOUSE
θ value	1.06291 (rank : 53)	NC score	0.146255 (rank : 38)
Query Neighborhood Hits	87	Target Neighborhood Hits	137	Shared Neighborhood Hits	45
SwissProt Accessions	Q7TSK7, Q3U0C8	Gene names	Adamtsl2, Kiaa0605, Tcp1
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2) (TSP1-repeats-containing protein 1) (TCP-1).

ATS12_MOUSE
θ value	1.38821 (rank : 54)	NC score	0.123661 (rank : 51)
Query Neighborhood Hits	87	Target Neighborhood Hits	220	Shared Neighborhood Hits	44
SwissProt Accessions	Q811B3, Q8BK92, Q8BKY1	Gene names	Adamts12
Domain Architecture	No domain graphic available
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

ATS18_HUMAN
θ value	1.38821 (rank : 55)	NC score	0.111886 (rank : 65)
Query Neighborhood Hits	87	Target Neighborhood Hits	169	Shared Neighborhood Hits	45
SwissProt Accessions	Q8TE60, Q6P4R5, Q6ZWJ9	Gene names	ADAMTS18, ADAMTS21
Domain Architecture
Description	ADAMTS-18 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18).

CO1A1_HUMAN
θ value	1.38821 (rank : 56)	NC score	0.035582 (rank : 140)
Query Neighborhood Hits	87	Target Neighborhood Hits	475	Shared Neighborhood Hits	21
SwissProt Accessions	P02452, P78441, Q13896, Q13902, Q13903, Q14037, Q14992, Q15176, Q15201, Q16050, Q7KZ30, Q7KZ34, Q8IVI5, Q9UML6, Q9UMM7	Gene names	COL1A1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

ATL1_HUMAN
θ value	1.81305 (rank : 57)	NC score	0.113508 (rank : 63)
Query Neighborhood Hits	87	Target Neighborhood Hits	93	Shared Neighborhood Hits	42
SwissProt Accessions	Q8N6G6, Q5T708, Q96RW4, Q9BXY3	Gene names	ADAMTSL1, ADAMTSR1
Domain Architecture
Description	ADAMTS-like protein 1 precursor (ADAMTSL-1) (Punctin-1).

ATS18_MOUSE
θ value	1.81305 (rank : 58)	NC score	0.115731 (rank : 57)
Query Neighborhood Hits	87	Target Neighborhood Hits	163	Shared Neighborhood Hits	45
SwissProt Accessions	Q4VC17, Q8BZD1	Gene names	Adamts18
Domain Architecture	No domain graphic available
Description	ADAMTS-18 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18).

ATS2_MOUSE
θ value	1.81305 (rank : 59)	NC score	0.108953 (rank : 73)
Query Neighborhood Hits	87	Target Neighborhood Hits	179	Shared Neighborhood Hits	41
SwissProt Accessions	Q8C9W3	Gene names	Adamts2
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

MUC2_HUMAN
θ value	1.81305 (rank : 60)	NC score	0.102783 (rank : 77)
Query Neighborhood Hits	87	Target Neighborhood Hits	906	Shared Neighborhood Hits	36
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

ATS15_HUMAN
θ value	2.36792 (rank : 61)	NC score	0.114609 (rank : 61)
Query Neighborhood Hits	87	Target Neighborhood Hits	151	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TE58	Gene names	ADAMTS15
Domain Architecture
Description	ADAMTS-15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 15) (ADAM-TS 15) (ADAM-TS15).

GFRA2_MOUSE
θ value	2.36792 (rank : 62)	NC score	0.021752 (rank : 144)
Query Neighborhood Hits	87	Target Neighborhood Hits	25	Shared Neighborhood Hits	4
SwissProt Accessions	O08842	Gene names	Gfra2, Gdnfrb, Trnr2
Domain Architecture
Description	GDNF family receptor alpha-2 precursor (GFR-alpha-2) (Neurturin receptor alpha) (NTNR-alpha) (NRTNR-alpha) (TGF-beta-related neurotrophic factor receptor 2) (GDNF receptor beta) (GDNFR-beta).

ATS9_HUMAN
θ value	3.0926 (rank : 63)	NC score	0.121607 (rank : 53)
Query Neighborhood Hits	87	Target Neighborhood Hits	219	Shared Neighborhood Hits	47
SwissProt Accessions	Q9P2N4, Q9NR29	Gene names	ADAMTS9, KIAA1312
Domain Architecture
Description	ADAMTS-9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 9) (ADAM-TS 9) (ADAM-TS9).

CO6_HUMAN
θ value	3.0926 (rank : 64)	NC score	0.068792 (rank : 109)
Query Neighborhood Hits	87	Target Neighborhood Hits	331	Shared Neighborhood Hits	44
SwissProt Accessions	P13671	Gene names	C6
Domain Architecture
Description	Complement component C6 precursor.

CRDL1_HUMAN
θ value	3.0926 (rank : 65)	NC score	0.157000 (rank : 33)
Query Neighborhood Hits	87	Target Neighborhood Hits	75	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BU40, Q9Y3H7	Gene names	CHRDL1, NRLN1
Domain Architecture
Description	Chordin-like protein 1 precursor (Neuralin-1) (Ventroptin) (Neurogenesin-1).

CRDL1_MOUSE
θ value	3.0926 (rank : 66)	NC score	0.162447 (rank : 31)
Query Neighborhood Hits	87	Target Neighborhood Hits	81	Shared Neighborhood Hits	26
SwissProt Accessions	Q920C1, Q924K0, Q9EPZ9	Gene names	Chrdl1, Ng1, Nrln1
Domain Architecture
Description	Chordin-like protein 1 precursor (Neuralin-1) (Ventroptin) (Neurogenesin-1).

GRN_HUMAN
θ value	3.0926 (rank : 67)	NC score	0.052375 (rank : 128)
Query Neighborhood Hits	87	Target Neighborhood Hits	268	Shared Neighborhood Hits	25
SwissProt Accessions	P28799, P23781, P23782, P23783, P23784, Q9BWE7, Q9UCH0	Gene names	GRN
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin; Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)].

KRA99_HUMAN
θ value	3.0926 (rank : 68)	NC score	0.029407 (rank : 143)
Query Neighborhood Hits	87	Target Neighborhood Hits	173	Shared Neighborhood Hits	19
SwissProt Accessions	Q9BYP9	Gene names	KRTAP9-9, KAP9.9, KRTAP9.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-9 (Keratin-associated protein 9.9) (Ultrahigh sulfur keratin-associated protein 9.9).

ATS17_HUMAN
θ value	4.03905 (rank : 69)	NC score	0.118350 (rank : 55)
Query Neighborhood Hits	87	Target Neighborhood Hits	194	Shared Neighborhood Hits	45
SwissProt Accessions	Q8TE56	Gene names	ADAMTS17
Domain Architecture
Description	ADAMTS-17 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 17) (ADAM-TS 17) (ADAM-TS17).

ATS20_HUMAN
θ value	4.03905 (rank : 70)	NC score	0.110104 (rank : 71)
Query Neighborhood Hits	87	Target Neighborhood Hits	192	Shared Neighborhood Hits	46
SwissProt Accessions	P59510	Gene names	ADAMTS20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

IBP1_MOUSE
θ value	4.03905 (rank : 71)	NC score	0.121985 (rank : 52)
Query Neighborhood Hits	87	Target Neighborhood Hits	97	Shared Neighborhood Hits	32
SwissProt Accessions	P47876, Q61732	Gene names	Igfbp1, Igfbp-1
Domain Architecture
Description	Insulin-like growth factor-binding protein 1 precursor (IGFBP-1) (IBP- 1) (IGF-binding protein 1).

MUC5B_HUMAN
θ value	4.03905 (rank : 72)	NC score	0.145042 (rank : 39)
Query Neighborhood Hits	87	Target Neighborhood Hits	1020	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

SEM5A_HUMAN
θ value	4.03905 (rank : 73)	NC score	0.076280 (rank : 98)
Query Neighborhood Hits	87	Target Neighborhood Hits	177	Shared Neighborhood Hits	45
SwissProt Accessions	Q13591, O60408, Q1RLL9	Gene names	SEMA5A, SEMAF
Domain Architecture
Description	Semaphorin-5A precursor (Semaphorin F) (Sema F).

SEM5A_MOUSE
θ value	4.03905 (rank : 74)	NC score	0.074090 (rank : 101)
Query Neighborhood Hits	87	Target Neighborhood Hits	162	Shared Neighborhood Hits	45
SwissProt Accessions	Q62217	Gene names	Sema5a, Semaf, SemF
Domain Architecture
Description	Semaphorin-5A precursor (Semaphorin F) (Sema F).

ATS2_HUMAN
θ value	5.27518 (rank : 75)	NC score	0.101218 (rank : 80)
Query Neighborhood Hits	87	Target Neighborhood Hits	179	Shared Neighborhood Hits	40
SwissProt Accessions	O95450	Gene names	ADAMTS2, PCINP, PCPNI
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

ATS6_HUMAN
θ value	5.27518 (rank : 76)	NC score	0.100844 (rank : 81)
Query Neighborhood Hits	87	Target Neighborhood Hits	141	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UKP5	Gene names	ADAMTS6
Domain Architecture
Description	ADAMTS-6 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 6) (ADAM-TS 6) (ADAM-TS6).

FRAS1_MOUSE
θ value	5.27518 (rank : 77)	NC score	0.110169 (rank : 70)
Query Neighborhood Hits	87	Target Neighborhood Hits	747	Shared Neighborhood Hits	59
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

GFRA2_HUMAN
θ value	5.27518 (rank : 78)	NC score	0.019541 (rank : 145)
Query Neighborhood Hits	87	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	O00451, O15316, O15328, Q7Z5C2	Gene names	GFRA2, GDNFRB, RETL2, TRNR2
Domain Architecture
Description	GDNF family receptor alpha-2 precursor (GFR-alpha-2) (Neurturin receptor alpha) (NTNR-alpha) (NRTNR-alpha) (TGF-beta-related neurotrophic factor receptor 2) (GDNF receptor beta) (GDNFR-beta) (RET ligand 2).

IBP1_HUMAN
θ value	5.27518 (rank : 79)	NC score	0.125696 (rank : 49)
Query Neighborhood Hits	87	Target Neighborhood Hits	67	Shared Neighborhood Hits	27
SwissProt Accessions	P08833, Q8IYP5	Gene names	IGFBP1, IBP1
Domain Architecture
Description	Insulin-like growth factor-binding protein 1 precursor (IGFBP-1) (IBP- 1) (IGF-binding protein 1) (Placental protein 12) (PP12).

GRN_MOUSE
θ value	6.88961 (rank : 80)	NC score	0.070298 (rank : 104)
Query Neighborhood Hits	87	Target Neighborhood Hits	248	Shared Neighborhood Hits	26
SwissProt Accessions	P28798	Gene names	Grn
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) (PC cell-derived growth factor) (PCDGF) [Contains: Acrogranin; Granulin-1; Granulin-2; Granulin-3; Granulin-4; Granulin-5; Granulin-6; Granulin-7].

IBP3_MOUSE
θ value	6.88961 (rank : 81)	NC score	0.117132 (rank : 56)
Query Neighborhood Hits	87	Target Neighborhood Hits	60	Shared Neighborhood Hits	29
SwissProt Accessions	P47878	Gene names	Igfbp3, Igfbp-3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

SOSD1_HUMAN
θ value	6.88961 (rank : 82)	NC score	0.061711 (rank : 117)
Query Neighborhood Hits	87	Target Neighborhood Hits	14	Shared Neighborhood Hits	9
SwissProt Accessions	Q6X4U4, Q96HJ7, Q9Y3U3	Gene names	SOSTDC1, USAG1
Domain Architecture	No domain graphic available
Description	Sclerostin domain-containing protein 1 precursor (Ectodermal BMP inhibitor) (Ectodin) (Uterine sensitization-associated gene 1 protein) (USAG-1).

SOSD1_MOUSE
θ value	6.88961 (rank : 83)	NC score	0.060039 (rank : 121)
Query Neighborhood Hits	87	Target Neighborhood Hits	14	Shared Neighborhood Hits	9
SwissProt Accessions	Q9CQN4, Q8CF09	Gene names	Sostdc1, Sostl, Usag1
Domain Architecture	No domain graphic available
Description	Sclerostin domain-containing protein 1 precursor (Ectodermal BMP inhibitor) (Ectodin) (Uterine sensitization-associated gene 1 protein) (USAG-1) (Sclerostin-like protein).

ATL3_HUMAN
θ value	8.99809 (rank : 84)	NC score	0.114529 (rank : 62)
Query Neighborhood Hits	87	Target Neighborhood Hits	414	Shared Neighborhood Hits	53
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

ATS7_HUMAN
θ value	8.99809 (rank : 85)	NC score	0.104354 (rank : 76)
Query Neighborhood Hits	87	Target Neighborhood Hits	169	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UKP4	Gene names	ADAMTS7
Domain Architecture
Description	ADAMTS-7 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 7) (ADAM-TS 7) (ADAM-TS7).

TRBM_HUMAN
θ value	8.99809 (rank : 86)	NC score	0.037423 (rank : 139)
Query Neighborhood Hits	87	Target Neighborhood Hits	339	Shared Neighborhood Hits	26
SwissProt Accessions	P07204, Q9UC32	Gene names	THBD, THRM
Domain Architecture
Description	Thrombomodulin precursor (TM) (Fetomodulin) (CD141 antigen).

TSP2_HUMAN
θ value	8.99809 (rank : 87)	NC score	0.114648 (rank : 60)
Query Neighborhood Hits	87	Target Neighborhood Hits	359	Shared Neighborhood Hits	63
SwissProt Accessions	P35442	Gene names	THBS2, TSP2
Domain Architecture
Description	Thrombospondin-2 precursor.

ATL1_MOUSE
θ value	θ > 10 (rank : 88)	NC score	0.091274 (rank : 86)
Query Neighborhood Hits	87	Target Neighborhood Hits	80	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BLI0	Gene names	Adamtsl1
Domain Architecture
Description	ADAMTS-like protein 1 precursor (Punctin-1).

ATL5_HUMAN
θ value	θ > 10 (rank : 89)	NC score	0.110796 (rank : 68)
Query Neighborhood Hits	87	Target Neighborhood Hits	103	Shared Neighborhood Hits	37
SwissProt Accessions	Q6ZMM2, Q8IW95	Gene names	ADAMTSL5, THSD6
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 5 precursor (ADAMTSL-5) (Thrombospondin type-1 domain-containing protein 6).

ATS13_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.099798 (rank : 82)
Query Neighborhood Hits	87	Target Neighborhood Hits	238	Shared Neighborhood Hits	40
SwissProt Accessions	Q76LX8, Q6UY16, Q710F6, Q711T8, Q96L37, Q9H0G3	Gene names	ADAMTS13, C9orf8
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

ATS13_MOUSE
θ value	θ > 10 (rank : 91)	NC score	0.097738 (rank : 83)
Query Neighborhood Hits	87	Target Neighborhood Hits	227	Shared Neighborhood Hits	40
SwissProt Accessions	Q769J6, Q76LW1	Gene names	Adamts13
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

ATS3_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.111717 (rank : 66)
Query Neighborhood Hits	87	Target Neighborhood Hits	179	Shared Neighborhood Hits	44
SwissProt Accessions	O15072, Q9BXZ8	Gene names	ADAMTS3, KIAA0366
Domain Architecture
Description	ADAMTS-3 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 3) (ADAM-TS 3) (ADAM-TS3) (Procollagen II amino propeptide-processing enzyme) (Procollagen II N-proteinase) (PC II-NP).

ATS4_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.088825 (rank : 90)
Query Neighborhood Hits	87	Target Neighborhood Hits	138	Shared Neighborhood Hits	33
SwissProt Accessions	O75173, Q5VTW2, Q6P4Q8, Q6UWA8, Q9UN83	Gene names	ADAMTS4, KIAA0688
Domain Architecture
Description	ADAMTS-4 precursor (EC 3.4.24.82) (A disintegrin and metalloproteinase with thrombospondin motifs 4) (ADAM-TS 4) (ADAM-TS4) (Aggrecanase-1) (ADMP-1).

ATS4_MOUSE
θ value	θ > 10 (rank : 94)	NC score	0.088517 (rank : 92)
Query Neighborhood Hits	87	Target Neighborhood Hits	145	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BNJ2, Q8K384	Gene names	Adamts4
Domain Architecture	No domain graphic available
Description	ADAMTS-4 precursor (EC 3.4.24.82) (A disintegrin and metalloproteinase with thrombospondin motifs 4) (ADAM-TS 4) (ADAM-TS4) (Aggrecanase-1).

ATS5_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.085215 (rank : 94)
Query Neighborhood Hits	87	Target Neighborhood Hits	141	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UNA0, Q9UKP2	Gene names	ADAMTS5, ADAMTS11, ADMP2
Domain Architecture
Description	ADAMTS-5 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 5) (ADAM-TS 5) (ADAM-TS5) (Aggrecanase-2) (ADMP-2) (ADAM-TS 11).

ATS5_MOUSE
θ value	θ > 10 (rank : 96)	NC score	0.088852 (rank : 89)
Query Neighborhood Hits	87	Target Neighborhood Hits	147	Shared Neighborhood Hits	37
SwissProt Accessions	Q9R001	Gene names	Adamts5
Domain Architecture
Description	ADAMTS-5 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 5) (ADAM-TS 5) (ADAM-TS5) (Aggrecanase-2) (ADMP-2) (Implantin).

ATS8_HUMAN
θ value	θ > 10 (rank : 97)	NC score	0.092573 (rank : 85)
Query Neighborhood Hits	87	Target Neighborhood Hits	145	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UP79, Q9NZS0	Gene names	ADAMTS8, METH2
Domain Architecture
Description	ADAMTS-8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2) (METH- 8).

ATS8_MOUSE
θ value	θ > 10 (rank : 98)	NC score	0.093535 (rank : 84)
Query Neighborhood Hits	87	Target Neighborhood Hits	139	Shared Neighborhood Hits	38
SwissProt Accessions	P57110	Gene names	Adamts8
Domain Architecture
Description	ADAMTS-8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2).

BAI1_HUMAN
θ value	θ > 10 (rank : 99)	NC score	0.072139 (rank : 102)
Query Neighborhood Hits	87	Target Neighborhood Hits	375	Shared Neighborhood Hits	42
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

BAI1_MOUSE
θ value	θ > 10 (rank : 100)	NC score	0.075484 (rank : 100)
Query Neighborhood Hits	87	Target Neighborhood Hits	340	Shared Neighborhood Hits	43
SwissProt Accessions	Q3UHD1, Q3UH36, Q8CGM0	Gene names	Bai1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1 precursor.

BAI2_HUMAN
θ value	θ > 10 (rank : 101)	NC score	0.068675 (rank : 110)
Query Neighborhood Hits	87	Target Neighborhood Hits	332	Shared Neighborhood Hits	42
SwissProt Accessions	O60241, Q5T6K0, Q8NGW8	Gene names	BAI2
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 2 precursor.

BAI2_MOUSE
θ value	θ > 10 (rank : 102)	NC score	0.068927 (rank : 107)
Query Neighborhood Hits	87	Target Neighborhood Hits	323	Shared Neighborhood Hits	43
SwissProt Accessions	Q8CGM1, Q3TYC8, Q3UN11, Q3UNE2, Q6PGN0	Gene names	Bai2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 2 precursor.

BAI3_HUMAN
θ value	θ > 10 (rank : 103)	NC score	0.065298 (rank : 114)
Query Neighborhood Hits	87	Target Neighborhood Hits	246	Shared Neighborhood Hits	39
SwissProt Accessions	O60242, O60297	Gene names	BAI3, KIAA0550
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

BAI3_MOUSE
θ value	θ > 10 (rank : 104)	NC score	0.068868 (rank : 108)
Query Neighborhood Hits	87	Target Neighborhood Hits	250	Shared Neighborhood Hits	42
SwissProt Accessions	Q80ZF8	Gene names	Bai3
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

CHRD_HUMAN
θ value	θ > 10 (rank : 105)	NC score	0.052246 (rank : 130)
Query Neighborhood Hits	87	Target Neighborhood Hits	102	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H2X0, O95254, Q6UW83, Q9H2D3, Q9H2W8, Q9H2W9, Q9P0Z2, Q9P0Z3, Q9P0Z4, Q9P0Z5	Gene names	CHRD
Domain Architecture
Description	Chordin precursor.

CI094_HUMAN
θ value	θ > 10 (rank : 106)	NC score	0.091120 (rank : 87)
Query Neighborhood Hits	87	Target Neighborhood Hits	310	Shared Neighborhood Hits	44
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

CO1A1_MOUSE
θ value	θ > 10 (rank : 107)	NC score	0.070485 (rank : 103)
Query Neighborhood Hits	87	Target Neighborhood Hits	457	Shared Neighborhood Hits	26
SwissProt Accessions	P11087, Q53WT0, Q60635, Q61367, Q61427, Q63919, Q6PCL3, Q810J9	Gene names	Col1a1, Cola1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

CRDL2_HUMAN
θ value	θ > 10 (rank : 108)	NC score	0.184064 (rank : 24)
Query Neighborhood Hits	87	Target Neighborhood Hits	99	Shared Neighborhood Hits	27
SwissProt Accessions	Q6WN34, Q6WN30, Q6WN31, Q6WN32, Q7Z5J3	Gene names	CHRDL2, BNF1, CHL2
Domain Architecture	No domain graphic available
Description	Chordin-like protein 2 precursor (Chordin-related protein 2) (Breast tumor novel factor 1) (BNF-1).

CRDL2_MOUSE
θ value	θ > 10 (rank : 109)	NC score	0.167065 (rank : 29)
Query Neighborhood Hits	87	Target Neighborhood Hits	81	Shared Neighborhood Hits	25
SwissProt Accessions	Q8VEA6, Q925I3	Gene names	Chrdl2, Chl2
Domain Architecture	No domain graphic available
Description	Chordin-like protein 2 precursor.

FRAS1_HUMAN
θ value	θ > 10 (rank : 110)	NC score	0.108915 (rank : 74)
Query Neighborhood Hits	87	Target Neighborhood Hits	759	Shared Neighborhood Hits	53
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

HMCN1_HUMAN
θ value	θ > 10 (rank : 111)	NC score	0.051370 (rank : 134)
Query Neighborhood Hits	87	Target Neighborhood Hits	983	Shared Neighborhood Hits	62
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

HTRA2_HUMAN
θ value	θ > 10 (rank : 112)	NC score	0.067841 (rank : 112)
Query Neighborhood Hits	87	Target Neighborhood Hits	30	Shared Neighborhood Hits	5
SwissProt Accessions	O43464, Q9HBZ4, Q9P0Y3, Q9P0Y4	Gene names	HTRA2, OMI, PRSS25
Domain Architecture
Description	Serine protease HTRA2, mitochondrial precursor (EC 3.4.21.-) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine proteinase OMI).

HTRA2_MOUSE
θ value	θ > 10 (rank : 113)	NC score	0.068044 (rank : 111)
Query Neighborhood Hits	87	Target Neighborhood Hits	29	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JIY5, Q9R108	Gene names	Htra2, Omi, Prss25
Domain Architecture
Description	Serine protease HTRA2, mitochondrial precursor (EC 3.4.21.-) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine proteinase OMI).

IBP4_HUMAN
θ value	θ > 10 (rank : 114)	NC score	0.105538 (rank : 75)
Query Neighborhood Hits	87	Target Neighborhood Hits	52	Shared Neighborhood Hits	22
SwissProt Accessions	P22692	Gene names	IGFBP4, IBP4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

IBP4_MOUSE
θ value	θ > 10 (rank : 115)	NC score	0.110538 (rank : 69)
Query Neighborhood Hits	87	Target Neighborhood Hits	55	Shared Neighborhood Hits	22
SwissProt Accessions	P47879, O35666	Gene names	Igfbp4, Igfbp-4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

KR104_HUMAN
θ value	θ > 10 (rank : 116)	NC score	0.075576 (rank : 99)
Query Neighborhood Hits	87	Target Neighborhood Hits	313	Shared Neighborhood Hits	34
SwissProt Accessions	P60372	Gene names	KRTAP10-4, KAP10.4, KAP18-4, KRTAP10.4, KRTAP18-4, KRTAP18.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-4 (Keratin-associated protein 10.4) (High sulfur keratin-associated protein 10.4) (Keratin-associated protein 18-4) (Keratin-associated protein 18.4).

KR106_HUMAN
θ value	θ > 10 (rank : 117)	NC score	0.050712 (rank : 136)
Query Neighborhood Hits	87	Target Neighborhood Hits	347	Shared Neighborhood Hits	34
SwissProt Accessions	P60371	Gene names	KRTAP10-6, KAP10.6, KAP18-6, KRTAP10.6, KRTAP18-6, KRTAP18.6
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-6 (Keratin-associated protein 10.6) (High sulfur keratin-associated protein 10.6) (Keratin-associated protein 18-6) (Keratin-associated protein 18.6).

KR107_HUMAN
θ value	θ > 10 (rank : 118)	NC score	0.062154 (rank : 116)
Query Neighborhood Hits	87	Target Neighborhood Hits	330	Shared Neighborhood Hits	33
SwissProt Accessions	P60409, Q70LJ2	Gene names	KRTAP10-7, KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-7 (Keratin-associated protein 10.7) (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7).

LCE1B_HUMAN
θ value	θ > 10 (rank : 119)	NC score	0.052087 (rank : 131)
Query Neighborhood Hits	87	Target Neighborhood Hits	58	Shared Neighborhood Hits	16
SwissProt Accessions	Q5T7P3	Gene names	LCE1B, LEP2, SPRL2A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1B (Late envelope protein 2) (Small proline-rich-like epidermal differentiation complex protein 2A).

LCE1C_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.059387 (rank : 122)
Query Neighborhood Hits	87	Target Neighborhood Hits	65	Shared Neighborhood Hits	16
SwissProt Accessions	Q5T751	Gene names	LCE1C, LEP3
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1C (Late envelope protein 3).

LCE1E_HUMAN
θ value	θ > 10 (rank : 121)	NC score	0.069289 (rank : 106)
Query Neighborhood Hits	87	Target Neighborhood Hits	53	Shared Neighborhood Hits	16
SwissProt Accessions	Q5T753	Gene names	LCE1E, LEP5
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1E (Late envelope protein 5).

LCE1F_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.051393 (rank : 133)
Query Neighborhood Hits	87	Target Neighborhood Hits	48	Shared Neighborhood Hits	12
SwissProt Accessions	Q5T754	Gene names	LCE1F, LEP6
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1F (Late envelope protein 6).

LCE2B_HUMAN
θ value	θ > 10 (rank : 123)	NC score	0.054957 (rank : 125)
Query Neighborhood Hits	87	Target Neighborhood Hits	50	Shared Neighborhood Hits	9
SwissProt Accessions	O14633	Gene names	LCE2B, LEP10, SPRL1B, XP5
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2B (Late envelope protein 10) (Small proline-rich-like epidermal differentiation complex protein 1B) (Skin- specific protein Xp5).

LCE2C_HUMAN
θ value	θ > 10 (rank : 124)	NC score	0.050038 (rank : 138)
Query Neighborhood Hits	87	Target Neighborhood Hits	53	Shared Neighborhood Hits	12
SwissProt Accessions	Q5TA81	Gene names	LCE2C, LEP11
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2C (Late envelope protein 11).

LCE2D_HUMAN
θ value	θ > 10 (rank : 125)	NC score	0.053376 (rank : 126)
Query Neighborhood Hits	87	Target Neighborhood Hits	50	Shared Neighborhood Hits	11
SwissProt Accessions	Q5TA82	Gene names	LCE2D, LEP12, SPRL1A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2D (Late envelope protein 12) (Small proline-rich-like epidermal differentiation complex protein 1A).

LCE4A_HUMAN
θ value	θ > 10 (rank : 126)	NC score	0.085953 (rank : 93)
Query Neighborhood Hits	87	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	Q5TA78	Gene names	LCE4A, LEP8, SPRL4A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 4A (Late envelope protein 8) (Small proline-rich-like epidermal differentiation complex protein 4A).

MCSP_MOUSE
θ value	θ > 10 (rank : 127)	NC score	0.079144 (rank : 96)
Query Neighborhood Hits	87	Target Neighborhood Hits	108	Shared Neighborhood Hits	15
SwissProt Accessions	P15265, O70613, Q6P8N3	Gene names	Smcp, Mcs, Mcsp
Domain Architecture	No domain graphic available
Description	Sperm mitochondrial-associated cysteine-rich protein.

MEGF6_HUMAN
θ value	θ > 10 (rank : 128)	NC score	0.050980 (rank : 135)
Query Neighborhood Hits	87	Target Neighborhood Hits	671	Shared Neighborhood Hits	50
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

NELL1_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.102479 (rank : 79)
Query Neighborhood Hits	87	Target Neighborhood Hits	451	Shared Neighborhood Hits	35
SwissProt Accessions	Q92832, Q9Y472	Gene names	NELL1, NRP1
Domain Architecture
Description	Protein kinase C-binding protein NELL1 precursor (NEL-like protein 1) (Nel-related protein 1).

NELL2_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.088794 (rank : 91)
Query Neighborhood Hits	87	Target Neighborhood Hits	449	Shared Neighborhood Hits	32
SwissProt Accessions	Q99435	Gene names	NELL2, NRP2
Domain Architecture
Description	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2).

NELL2_MOUSE
θ value	θ > 10 (rank : 131)	NC score	0.089298 (rank : 88)
Query Neighborhood Hits	87	Target Neighborhood Hits	436	Shared Neighborhood Hits	33
SwissProt Accessions	Q61220	Gene names	Nell2, Mel91
Domain Architecture
Description	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (MEL91 protein).

PROP_HUMAN
θ value	θ > 10 (rank : 132)	NC score	0.078719 (rank : 97)
Query Neighborhood Hits	87	Target Neighborhood Hits	126	Shared Neighborhood Hits	35
SwissProt Accessions	P27918, O15134, O15135, O15136, O75826	Gene names	CFP, PFC
Domain Architecture
Description	Properdin precursor (Factor P).

PROP_MOUSE
θ value	θ > 10 (rank : 133)	NC score	0.079740 (rank : 95)
Query Neighborhood Hits	87	Target Neighborhood Hits	165	Shared Neighborhood Hits	37
SwissProt Accessions	P11680, Q3TB98, Q3U779	Gene names	Cfp, Pfc
Domain Architecture	No domain graphic available
Description	Properdin precursor (Factor P).

RECK_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.059296 (rank : 123)
Query Neighborhood Hits	87	Target Neighborhood Hits	189	Shared Neighborhood Hits	32
SwissProt Accessions	O95980, Q8WX37	Gene names	RECK
Domain Architecture
Description	Reversion-inducing cysteine-rich protein with Kazal motifs precursor (hRECK) (Suppressor of tumorigenicity 15) (ST15).

RECK_MOUSE
θ value	θ > 10 (rank : 135)	NC score	0.058107 (rank : 124)
Query Neighborhood Hits	87	Target Neighborhood Hits	158	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Z0J1	Gene names	Reck
Domain Architecture	No domain graphic available
Description	Reversion-inducing cysteine-rich protein with Kazal motifs precursor (mRECK).

RSPO4_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.050098 (rank : 137)
Query Neighborhood Hits	87	Target Neighborhood Hits	110	Shared Neighborhood Hits	24
SwissProt Accessions	Q2I0M5, Q9UGB2	Gene names	RSPO4, C20orf182
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (hRspo4).

SEM5B_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.060320 (rank : 120)
Query Neighborhood Hits	87	Target Neighborhood Hits	178	Shared Neighborhood Hits	44
SwissProt Accessions	Q9P283, Q6UY12	Gene names	SEMA5B, KIAA1445
Domain Architecture
Description	Semaphorin-5B precursor.

SEM5B_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.063823 (rank : 115)
Query Neighborhood Hits	87	Target Neighborhood Hits	190	Shared Neighborhood Hits	43
SwissProt Accessions	Q60519	Gene names	Sema5b, Semag, SemG
Domain Architecture
Description	Semaphorin-5B precursor (Semaphorin G) (Sema G).

SREC_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.051752 (rank : 132)
Query Neighborhood Hits	87	Target Neighborhood Hits	645	Shared Neighborhood Hits	35
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

TECTA_HUMAN
θ value	θ > 10 (rank : 140)	NC score	0.067031 (rank : 113)
Query Neighborhood Hits	87	Target Neighborhood Hits	239	Shared Neighborhood Hits	24
SwissProt Accessions	O75443	Gene names	TECTA
Domain Architecture
Description	Alpha-tectorin precursor.

TECTA_MOUSE
θ value	θ > 10 (rank : 141)	NC score	0.070078 (rank : 105)
Query Neighborhood Hits	87	Target Neighborhood Hits	244	Shared Neighborhood Hits	23
SwissProt Accessions	O08523	Gene names	Tecta
Domain Architecture
Description	Alpha-tectorin precursor.

THSD1_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.060965 (rank : 119)
Query Neighborhood Hits	87	Target Neighborhood Hits	136	Shared Neighborhood Hits	34
SwissProt Accessions	Q9NS62, Q6P3U1, Q6UXZ2	Gene names	THSD1, TMTSP
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

THSD1_MOUSE
θ value	θ > 10 (rank : 143)	NC score	0.060983 (rank : 118)
Query Neighborhood Hits	87	Target Neighborhood Hits	153	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JM61, Q8C7Q9	Gene names	Thsd1, Tmtsp
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

TSP2_MOUSE
θ value	θ > 10 (rank : 144)	NC score	0.112551 (rank : 64)
Query Neighborhood Hits	87	Target Neighborhood Hits	352	Shared Neighborhood Hits	60
SwissProt Accessions	Q03350	Gene names	Thbs2, Tsp2
Domain Architecture
Description	Thrombospondin-2 precursor.

ZAN_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.102624 (rank : 78)
Query Neighborhood Hits	87	Target Neighborhood Hits	679	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

Hits sorted by NC score

WISP3_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	87	Target Neighborhood Hits	87	Shared Neighborhood Hits	87
SwissProt Accessions	O95389, Q6UXH6	Gene names	WISP3, CCN6
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 3 precursor (WISP-3).

WISP1_HUMAN
NC score	0.960646 (rank : 2)	θ value	5.50685e-82 (rank : 2)
Query Neighborhood Hits	87	Target Neighborhood Hits	121	Shared Neighborhood Hits	69
SwissProt Accessions	O95388, Q9HCS3	Gene names	WISP1, CCN4
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (Wnt-1- induced secreted protein).

WISP1_MOUSE
NC score	0.956399 (rank : 3)	θ value	1.14825e-79 (rank : 3)
Query Neighborhood Hits	87	Target Neighborhood Hits	123	Shared Neighborhood Hits	74
SwissProt Accessions	O54775, Q80ZL1	Gene names	Wisp1, Ccn4, Elm1
Domain Architecture
Description	WNT1-inducible signaling pathway protein 1 precursor (WISP-1) (ELM-1).

CTGF_MOUSE
NC score	0.950069 (rank : 4)	θ value	5.53243e-66 (rank : 5)
Query Neighborhood Hits	87	Target Neighborhood Hits	124	Shared Neighborhood Hits	74
SwissProt Accessions	P29268, Q922U0	Gene names	Ctgf, Ccn2, Fisp-12, Fisp12, Hcs24
Domain Architecture
Description	Connective tissue growth factor precursor (Protein FISP-12) (Hypertrophic chondrocyte-specific protein 24).

CTGF_HUMAN
NC score	0.946488 (rank : 5)	θ value	1.7756e-72 (rank : 4)
Query Neighborhood Hits	87	Target Neighborhood Hits	128	Shared Neighborhood Hits	72
SwissProt Accessions	P29279, Q96QX2	Gene names	CTGF, CCN2, HCS24
Domain Architecture
Description	Connective tissue growth factor precursor (Hypertrophic chondrocyte- specific protein 24).

NOV_MOUSE
NC score	0.943761 (rank : 6)	θ value	9.45883e-58 (rank : 6)
Query Neighborhood Hits	87	Target Neighborhood Hits	130	Shared Neighborhood Hits	72
SwissProt Accessions	Q64299, Q8CA67	Gene names	Nov, Ccn3
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

NOV_HUMAN
NC score	0.936542 (rank : 7)	θ value	3.0428e-56 (rank : 7)
Query Neighborhood Hits	87	Target Neighborhood Hits	128	Shared Neighborhood Hits	69
SwissProt Accessions	P48745, Q96BY5	Gene names	NOV, CCN3, IGFBP9, NOVH
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

CYR61_HUMAN
NC score	0.933601 (rank : 8)	θ value	1.66964e-54 (rank : 9)
Query Neighborhood Hits	87	Target Neighborhood Hits	159	Shared Neighborhood Hits	77
SwissProt Accessions	O00622, O14934, O43775, Q9BZL7	Gene names	CYR61, CCN1, GIG1, IGFBP10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (Protein GIG1).

CYR61_MOUSE
NC score	0.933422 (rank : 9)	θ value	4.39379e-55 (rank : 8)
Query Neighborhood Hits	87	Target Neighborhood Hits	156	Shared Neighborhood Hits	74
SwissProt Accessions	P18406	Gene names	Cyr61, Ccn1, Igfbp10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (3CH61).

WISP2_HUMAN
NC score	0.893546 (rank : 10)	θ value	2.59989e-23 (rank : 11)
Query Neighborhood Hits	87	Target Neighborhood Hits	126	Shared Neighborhood Hits	73
SwissProt Accessions	O76076	Gene names	WISP2, CCN5, CT58, CTGFL
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L) (Connective tissue growth factor-related protein 58).

WISP2_MOUSE
NC score	0.888259 (rank : 11)	θ value	2.51237e-26 (rank : 10)
Query Neighborhood Hits	87	Target Neighborhood Hits	129	Shared Neighborhood Hits	73
SwissProt Accessions	Q9Z0G4, Q8CIC8	Gene names	Wisp2, Ccn5, Ctgfl
Domain Architecture
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L).

ESM1_MOUSE
NC score	0.324619 (rank : 12)	θ value	0.0330416 (rank : 24)
Query Neighborhood Hits	87	Target Neighborhood Hits	107	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QYY7	Gene names	Esm1
Domain Architecture
Description	Endothelial cell-specific molecule 1 precursor (ESM-1 secretory protein) (ESM-1).

ESM1_HUMAN
NC score	0.291986 (rank : 13)	θ value	0.813845 (rank : 49)
Query Neighborhood Hits	87	Target Neighborhood Hits	110	Shared Neighborhood Hits	31
SwissProt Accessions	Q9NQ30, Q15330, Q96ES3	Gene names	ESM1
Domain Architecture	No domain graphic available
Description	Endothelial cell-specific molecule 1 precursor (ESM-1 secretory protein) (ESM-1).

HTRA4_HUMAN
NC score	0.248787 (rank : 14)	θ value	0.0736092 (rank : 26)
Query Neighborhood Hits	87	Target Neighborhood Hits	119	Shared Neighborhood Hits	31
SwissProt Accessions	P83105, Q542Z4, Q6PF13	Gene names	HTRA4
Domain Architecture	No domain graphic available
Description	Probable serine protease HTRA4 precursor (EC 3.4.21.-).

BMPER_MOUSE
NC score	0.234848 (rank : 15)	θ value	0.0961366 (rank : 30)
Query Neighborhood Hits	87	Target Neighborhood Hits	194	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CJ69, Q7TN57, Q80UZ1, Q9CXM8	Gene names	Bmper, Cv2
Domain Architecture
Description	BMP-binding endothelial regulator protein precursor (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (mCV2).

HTRA1_HUMAN
NC score	0.229730 (rank : 16)	θ value	0.00869519 (rank : 16)
Query Neighborhood Hits	87	Target Neighborhood Hits	155	Shared Neighborhood Hits	33
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

BMPER_HUMAN
NC score	0.227044 (rank : 17)	θ value	0.365318 (rank : 38)
Query Neighborhood Hits	87	Target Neighborhood Hits	175	Shared Neighborhood Hits	33
SwissProt Accessions	Q8N8U9	Gene names	BMPER
Domain Architecture
Description	BMP-binding endothelial regulator protein precursor (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (hCV2).

HTRA3_MOUSE
NC score	0.221777 (rank : 18)	θ value	0.0113563 (rank : 21)
Query Neighborhood Hits	87	Target Neighborhood Hits	156	Shared Neighborhood Hits	33
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

HTRA1_MOUSE
NC score	0.220588 (rank : 19)	θ value	0.365318 (rank : 39)
Query Neighborhood Hits	87	Target Neighborhood Hits	140	Shared Neighborhood Hits	31
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

CRIM1_HUMAN
NC score	0.220155 (rank : 20)	θ value	0.00134147 (rank : 13)
Query Neighborhood Hits	87	Target Neighborhood Hits	362	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

HTRA3_HUMAN
NC score	0.219968 (rank : 21)	θ value	0.0113563 (rank : 20)
Query Neighborhood Hits	87	Target Neighborhood Hits	152	Shared Neighborhood Hits	31
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

IBP2_MOUSE
NC score	0.195053 (rank : 22)	θ value	0.0736092 (rank : 27)
Query Neighborhood Hits	87	Target Neighborhood Hits	65	Shared Neighborhood Hits	30
SwissProt Accessions	P47877, Q61722	Gene names	Igfbp2, Igfbp-2
Domain Architecture
Description	Insulin-like growth factor-binding protein 2 precursor (IGFBP-2) (IBP- 2) (IGF-binding protein 2).

IBP7_MOUSE
NC score	0.189210 (rank : 23)	θ value	0.163984 (rank : 32)
Query Neighborhood Hits	87	Target Neighborhood Hits	230	Shared Neighborhood Hits	34
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

CRDL2_HUMAN
NC score	0.184064 (rank : 24)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	87	Target Neighborhood Hits	99	Shared Neighborhood Hits	27
SwissProt Accessions	Q6WN34, Q6WN30, Q6WN31, Q6WN32, Q7Z5J3	Gene names	CHRDL2, BNF1, CHL2
Domain Architecture	No domain graphic available
Description	Chordin-like protein 2 precursor (Chordin-related protein 2) (Breast tumor novel factor 1) (BNF-1).

IBP2_HUMAN
NC score	0.176588 (rank : 25)	θ value	0.0563607 (rank : 25)
Query Neighborhood Hits	87	Target Neighborhood Hits	61	Shared Neighborhood Hits	30
SwissProt Accessions	P18065, Q14619, Q9UCL3	Gene names	IGFBP2, BP2
Domain Architecture
Description	Insulin-like growth factor-binding protein 2 precursor (IGFBP-2) (IBP- 2) (IGF-binding protein 2).

IBP7_HUMAN
NC score	0.175673 (rank : 26)	θ value	0.279714 (rank : 33)
Query Neighborhood Hits	87	Target Neighborhood Hits	220	Shared Neighborhood Hits	30
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

SSPO_MOUSE
NC score	0.172804 (rank : 27)	θ value	0.00298849 (rank : 14)
Query Neighborhood Hits	87	Target Neighborhood Hits	800	Shared Neighborhood Hits	69
SwissProt Accessions	Q8CG65	Gene names	Sspo
Domain Architecture	No domain graphic available
Description	SCO-spondin precursor.

SPON1_HUMAN
NC score	0.169506 (rank : 28)	θ value	0.0736092 (rank : 28)
Query Neighborhood Hits	87	Target Neighborhood Hits	117	Shared Neighborhood Hits	47
SwissProt Accessions	Q9HCB6, O94862, Q8NCD7, Q8WUR5	Gene names	SPON1, KIAA0762, VSGP
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin) (Vascular smooth muscle cell growth- promoting factor).

CRDL2_MOUSE
NC score	0.167065 (rank : 29)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	87	Target Neighborhood Hits	81	Shared Neighborhood Hits	25
SwissProt Accessions	Q8VEA6, Q925I3	Gene names	Chrdl2, Chl2
Domain Architecture	No domain graphic available
Description	Chordin-like protein 2 precursor.

SPON1_MOUSE
NC score	0.166607 (rank : 30)	θ value	0.0961366 (rank : 31)
Query Neighborhood Hits	87	Target Neighborhood Hits	123	Shared Neighborhood Hits	46
SwissProt Accessions	Q8VCC9, Q8K2Q8	Gene names	Spon1
Domain Architecture	No domain graphic available
Description	Spondin-1 precursor (F-spondin).

CRDL1_MOUSE
NC score	0.162447 (rank : 31)	θ value	3.0926 (rank : 66)
Query Neighborhood Hits	87	Target Neighborhood Hits	81	Shared Neighborhood Hits	26
SwissProt Accessions	Q920C1, Q924K0, Q9EPZ9	Gene names	Chrdl1, Ng1, Nrln1
Domain Architecture
Description	Chordin-like protein 1 precursor (Neuralin-1) (Ventroptin) (Neurogenesin-1).

IBP5_MOUSE
NC score	0.158437 (rank : 32)	θ value	0.47712 (rank : 43)
Query Neighborhood Hits	87	Target Neighborhood Hits	68	Shared Neighborhood Hits	31
SwissProt Accessions	Q07079	Gene names	Igfbp5, Igfbp-5
Domain Architecture
Description	Insulin-like growth factor-binding protein 5 precursor (IGFBP-5) (IBP- 5) (IGF-binding protein 5).

CRDL1_HUMAN
NC score	0.157000 (rank : 33)	θ value	3.0926 (rank : 65)
Query Neighborhood Hits	87	Target Neighborhood Hits	75	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BU40, Q9Y3H7	Gene names	CHRDL1, NRLN1
Domain Architecture
Description	Chordin-like protein 1 precursor (Neuralin-1) (Ventroptin) (Neurogenesin-1).

IBP5_HUMAN
NC score	0.156680 (rank : 34)	θ value	0.47712 (rank : 42)
Query Neighborhood Hits	87	Target Neighborhood Hits	68	Shared Neighborhood Hits	31
SwissProt Accessions	P24593	Gene names	IGFBP5, IBP5
Domain Architecture
Description	Insulin-like growth factor-binding protein 5 precursor (IGFBP-5) (IBP- 5) (IGF-binding protein 5).

VWF_HUMAN
NC score	0.147884 (rank : 35)	θ value	0.000158464 (rank : 12)
Query Neighborhood Hits	87	Target Neighborhood Hits	396	Shared Neighborhood Hits	40
SwissProt Accessions	P04275	Gene names	VWF, F8VWF
Domain Architecture
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

ATL2_HUMAN
NC score	0.147780 (rank : 36)	θ value	1.06291 (rank : 52)
Query Neighborhood Hits	87	Target Neighborhood Hits	125	Shared Neighborhood Hits	45
SwissProt Accessions	Q86TH1, O60345	Gene names	ADAMTSL2, KIAA0605
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2).

VWF_MOUSE
NC score	0.147531 (rank : 37)	θ value	0.00869519 (rank : 18)
Query Neighborhood Hits	87	Target Neighborhood Hits	381	Shared Neighborhood Hits	33
SwissProt Accessions	Q8CIZ8, Q60863, Q6XUV6, Q8BIU9, Q8CGN0, Q9JK16	Gene names	Vwf
Domain Architecture	No domain graphic available
Description	von Willebrand factor precursor (vWF) [Contains: von Willebrand antigen 2 (von Willebrand antigen II)].

ATL2_MOUSE
NC score	0.146255 (rank : 38)	θ value	1.06291 (rank : 53)
Query Neighborhood Hits	87	Target Neighborhood Hits	137	Shared Neighborhood Hits	45
SwissProt Accessions	Q7TSK7, Q3U0C8	Gene names	Adamtsl2, Kiaa0605, Tcp1
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 2 precursor (ADAMTSL-2) (TSP1-repeats-containing protein 1) (TCP-1).

MUC5B_HUMAN
NC score	0.145042 (rank : 39)	θ value	4.03905 (rank : 72)
Query Neighborhood Hits	87	Target Neighborhood Hits	1020	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

KAZD1_HUMAN
NC score	0.141081 (rank : 40)	θ value	0.813845 (rank : 50)
Query Neighborhood Hits	87	Target Neighborhood Hits	248	Shared Neighborhood Hits	31
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

TSP1_HUMAN
NC score	0.140919 (rank : 41)	θ value	0.0148317 (rank : 22)
Query Neighborhood Hits	87	Target Neighborhood Hits	389	Shared Neighborhood Hits	61
SwissProt Accessions	P07996, Q15667	Gene names	THBS1, TSP, TSP1
Domain Architecture
Description	Thrombospondin-1 precursor.

TSP1_MOUSE
NC score	0.138707 (rank : 42)	θ value	0.00869519 (rank : 17)
Query Neighborhood Hits	87	Target Neighborhood Hits	396	Shared Neighborhood Hits	61
SwissProt Accessions	P35441	Gene names	Thbs1, Tsp1
Domain Architecture
Description	Thrombospondin-1 precursor.

KAZD1_MOUSE
NC score	0.138378 (rank : 43)	θ value	0.279714 (rank : 34)
Query Neighborhood Hits	87	Target Neighborhood Hits	281	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

ATS1_MOUSE
NC score	0.134020 (rank : 44)	θ value	0.00869519 (rank : 15)
Query Neighborhood Hits	87	Target Neighborhood Hits	158	Shared Neighborhood Hits	47
SwissProt Accessions	P97857, O54768	Gene names	Adamts1
Domain Architecture
Description	ADAMTS-1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 1) (ADAM-TS 1) (ADAM-TS1).

ATS19_MOUSE
NC score	0.132471 (rank : 45)	θ value	0.0330416 (rank : 23)
Query Neighborhood Hits	87	Target Neighborhood Hits	188	Shared Neighborhood Hits	46
SwissProt Accessions	P59509	Gene names	Adamts19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

IBP3_HUMAN
NC score	0.132289 (rank : 46)	θ value	0.62314 (rank : 46)
Query Neighborhood Hits	87	Target Neighborhood Hits	67	Shared Neighborhood Hits	29
SwissProt Accessions	P17936, Q2V509, Q6P1M6	Gene names	IGFBP3, IBP3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

ATS19_HUMAN
NC score	0.131351 (rank : 47)	θ value	0.0113563 (rank : 19)
Query Neighborhood Hits	87	Target Neighborhood Hits	203	Shared Neighborhood Hits	45
SwissProt Accessions	Q8TE59	Gene names	ADAMTS19
Domain Architecture
Description	ADAMTS-19 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 19) (ADAM-TS 19) (ADAM-TS19).

ATS12_HUMAN
NC score	0.129938 (rank : 48)	θ value	0.62314 (rank : 44)
Query Neighborhood Hits	87	Target Neighborhood Hits	251	Shared Neighborhood Hits	48
SwissProt Accessions	P58397, Q6UWL3	Gene names	ADAMTS12
Domain Architecture
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

IBP1_HUMAN
NC score	0.125696 (rank : 49)	θ value	5.27518 (rank : 79)
Query Neighborhood Hits	87	Target Neighborhood Hits	67	Shared Neighborhood Hits	27
SwissProt Accessions	P08833, Q8IYP5	Gene names	IGFBP1, IBP1
Domain Architecture
Description	Insulin-like growth factor-binding protein 1 precursor (IGFBP-1) (IBP- 1) (IGF-binding protein 1) (Placental protein 12) (PP12).

ATS1_HUMAN
NC score	0.124104 (rank : 50)	θ value	0.0961366 (rank : 29)
Query Neighborhood Hits	87	Target Neighborhood Hits	159	Shared Neighborhood Hits	45
SwissProt Accessions	Q9UHI8, Q9NSJ8, Q9P2K0, Q9UH83, Q9UP80	Gene names	ADAMTS1, KIAA1346, METH1
Domain Architecture
Description	ADAMTS-1 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 1) (ADAM-TS 1) (ADAM-TS1) (METH-1).

ATS12_MOUSE
NC score	0.123661 (rank : 51)	θ value	1.38821 (rank : 54)
Query Neighborhood Hits	87	Target Neighborhood Hits	220	Shared Neighborhood Hits	44
SwissProt Accessions	Q811B3, Q8BK92, Q8BKY1	Gene names	Adamts12
Domain Architecture	No domain graphic available
Description	ADAMTS-12 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 12) (ADAM-TS 12) (ADAM-TS12).

IBP1_MOUSE
NC score	0.121985 (rank : 52)	θ value	4.03905 (rank : 71)
Query Neighborhood Hits	87	Target Neighborhood Hits	97	Shared Neighborhood Hits	32
SwissProt Accessions	P47876, Q61732	Gene names	Igfbp1, Igfbp-1
Domain Architecture
Description	Insulin-like growth factor-binding protein 1 precursor (IGFBP-1) (IBP- 1) (IGF-binding protein 1).

ATS9_HUMAN
NC score	0.121607 (rank : 53)	θ value	3.0926 (rank : 63)
Query Neighborhood Hits	87	Target Neighborhood Hits	219	Shared Neighborhood Hits	47
SwissProt Accessions	Q9P2N4, Q9NR29	Gene names	ADAMTS9, KIAA1312
Domain Architecture
Description	ADAMTS-9 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 9) (ADAM-TS 9) (ADAM-TS9).

ATS20_MOUSE
NC score	0.120476 (rank : 54)	θ value	0.813845 (rank : 48)
Query Neighborhood Hits	87	Target Neighborhood Hits	225	Shared Neighborhood Hits	48
SwissProt Accessions	P59511	Gene names	Adamts20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

ATS17_HUMAN
NC score	0.118350 (rank : 55)	θ value	4.03905 (rank : 69)
Query Neighborhood Hits	87	Target Neighborhood Hits	194	Shared Neighborhood Hits	45
SwissProt Accessions	Q8TE56	Gene names	ADAMTS17
Domain Architecture
Description	ADAMTS-17 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 17) (ADAM-TS 17) (ADAM-TS17).

IBP3_MOUSE
NC score	0.117132 (rank : 56)	θ value	6.88961 (rank : 81)
Query Neighborhood Hits	87	Target Neighborhood Hits	60	Shared Neighborhood Hits	29
SwissProt Accessions	P47878	Gene names	Igfbp3, Igfbp-3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

ATS18_MOUSE
NC score	0.115731 (rank : 57)	θ value	1.81305 (rank : 58)
Query Neighborhood Hits	87	Target Neighborhood Hits	163	Shared Neighborhood Hits	45
SwissProt Accessions	Q4VC17, Q8BZD1	Gene names	Adamts18
Domain Architecture	No domain graphic available
Description	ADAMTS-18 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18).

ATS16_HUMAN
NC score	0.115409 (rank : 58)	θ value	0.47712 (rank : 41)
Query Neighborhood Hits	87	Target Neighborhood Hits	208	Shared Neighborhood Hits	45
SwissProt Accessions	Q8TE57, Q8IVE2	Gene names	ADAMTS16, KIAA2029
Domain Architecture
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

ATS16_MOUSE
NC score	0.115384 (rank : 59)	θ value	0.813845 (rank : 47)
Query Neighborhood Hits	87	Target Neighborhood Hits	179	Shared Neighborhood Hits	46
SwissProt Accessions	Q69Z28, Q8K206	Gene names	Adamts16, Kiaa2029
Domain Architecture	No domain graphic available
Description	ADAMTS-16 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 16) (ADAM-TS 16) (ADAM-TS16).

TSP2_HUMAN
NC score	0.114648 (rank : 60)	θ value	8.99809 (rank : 87)
Query Neighborhood Hits	87	Target Neighborhood Hits	359	Shared Neighborhood Hits	63
SwissProt Accessions	P35442	Gene names	THBS2, TSP2
Domain Architecture
Description	Thrombospondin-2 precursor.

ATS15_HUMAN
NC score	0.114609 (rank : 61)	θ value	2.36792 (rank : 61)
Query Neighborhood Hits	87	Target Neighborhood Hits	151	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TE58	Gene names	ADAMTS15
Domain Architecture
Description	ADAMTS-15 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 15) (ADAM-TS 15) (ADAM-TS15).

ATL3_HUMAN
NC score	0.114529 (rank : 62)	θ value	8.99809 (rank : 84)
Query Neighborhood Hits	87	Target Neighborhood Hits	414	Shared Neighborhood Hits	53
SwissProt Accessions	P82987, Q9ULI7	Gene names	ADAMTSL3, KIAA1233
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 3 precursor (ADAMTSL-3) (Punctin-2).

ATL1_HUMAN
NC score	0.113508 (rank : 63)	θ value	1.81305 (rank : 57)
Query Neighborhood Hits	87	Target Neighborhood Hits	93	Shared Neighborhood Hits	42
SwissProt Accessions	Q8N6G6, Q5T708, Q96RW4, Q9BXY3	Gene names	ADAMTSL1, ADAMTSR1
Domain Architecture
Description	ADAMTS-like protein 1 precursor (ADAMTSL-1) (Punctin-1).

TSP2_MOUSE
NC score	0.112551 (rank : 64)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	87	Target Neighborhood Hits	352	Shared Neighborhood Hits	60
SwissProt Accessions	Q03350	Gene names	Thbs2, Tsp2
Domain Architecture
Description	Thrombospondin-2 precursor.

ATS18_HUMAN
NC score	0.111886 (rank : 65)	θ value	1.38821 (rank : 55)
Query Neighborhood Hits	87	Target Neighborhood Hits	169	Shared Neighborhood Hits	45
SwissProt Accessions	Q8TE60, Q6P4R5, Q6ZWJ9	Gene names	ADAMTS18, ADAMTS21
Domain Architecture
Description	ADAMTS-18 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 18) (ADAM-TS 18) (ADAM-TS18).

ATS3_HUMAN
NC score	0.111717 (rank : 66)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	87	Target Neighborhood Hits	179	Shared Neighborhood Hits	44
SwissProt Accessions	O15072, Q9BXZ8	Gene names	ADAMTS3, KIAA0366
Domain Architecture
Description	ADAMTS-3 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 3) (ADAM-TS 3) (ADAM-TS3) (Procollagen II amino propeptide-processing enzyme) (Procollagen II N-proteinase) (PC II-NP).

ZAN_MOUSE
NC score	0.111696 (rank : 67)	θ value	0.279714 (rank : 37)
Query Neighborhood Hits	87	Target Neighborhood Hits	808	Shared Neighborhood Hits	49
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

ATL5_HUMAN
NC score	0.110796 (rank : 68)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	87	Target Neighborhood Hits	103	Shared Neighborhood Hits	37
SwissProt Accessions	Q6ZMM2, Q8IW95	Gene names	ADAMTSL5, THSD6
Domain Architecture	No domain graphic available
Description	ADAMTS-like protein 5 precursor (ADAMTSL-5) (Thrombospondin type-1 domain-containing protein 6).

IBP4_MOUSE
NC score	0.110538 (rank : 69)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	87	Target Neighborhood Hits	55	Shared Neighborhood Hits	22
SwissProt Accessions	P47879, O35666	Gene names	Igfbp4, Igfbp-4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

FRAS1_MOUSE
NC score	0.110169 (rank : 70)	θ value	5.27518 (rank : 77)
Query Neighborhood Hits	87	Target Neighborhood Hits	747	Shared Neighborhood Hits	59
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

ATS20_HUMAN
NC score	0.110104 (rank : 71)	θ value	4.03905 (rank : 70)
Query Neighborhood Hits	87	Target Neighborhood Hits	192	Shared Neighborhood Hits	46
SwissProt Accessions	P59510	Gene names	ADAMTS20
Domain Architecture
Description	ADAMTS-20 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 20) (ADAM-TS 20) (ADAM-TS20).

ATS14_HUMAN
NC score	0.109450 (rank : 72)	θ value	0.62314 (rank : 45)
Query Neighborhood Hits	87	Target Neighborhood Hits	382	Shared Neighborhood Hits	47
SwissProt Accessions	Q8WXS8, Q8TE55, Q8TEY8	Gene names	ADAMTS14
Domain Architecture
Description	ADAMTS-14 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 14) (ADAM-TS 14) (ADAM-TS14).

ATS2_MOUSE
NC score	0.108953 (rank : 73)	θ value	1.81305 (rank : 59)
Query Neighborhood Hits	87	Target Neighborhood Hits	179	Shared Neighborhood Hits	41
SwissProt Accessions	Q8C9W3	Gene names	Adamts2
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

FRAS1_HUMAN
NC score	0.108915 (rank : 74)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	87	Target Neighborhood Hits	759	Shared Neighborhood Hits	53
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

IBP4_HUMAN
NC score	0.105538 (rank : 75)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	87	Target Neighborhood Hits	52	Shared Neighborhood Hits	22
SwissProt Accessions	P22692	Gene names	IGFBP4, IBP4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

ATS7_HUMAN
NC score	0.104354 (rank : 76)	θ value	8.99809 (rank : 85)
Query Neighborhood Hits	87	Target Neighborhood Hits	169	Shared Neighborhood Hits	41
SwissProt Accessions	Q9UKP4	Gene names	ADAMTS7
Domain Architecture
Description	ADAMTS-7 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 7) (ADAM-TS 7) (ADAM-TS7).

MUC2_HUMAN
NC score	0.102783 (rank : 77)	θ value	1.81305 (rank : 60)
Query Neighborhood Hits	87	Target Neighborhood Hits	906	Shared Neighborhood Hits	36
SwissProt Accessions	Q02817, Q14878	Gene names	MUC2, SMUC
Domain Architecture
Description	Mucin-2 precursor (Intestinal mucin-2).

ZAN_HUMAN
NC score	0.102624 (rank : 78)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	87	Target Neighborhood Hits	679	Shared Neighborhood Hits	40
SwissProt Accessions	Q9Y493, O00218, Q96L85, Q96L86, Q96L87, Q96L88, Q96L89, Q96L90, Q9BXN9, Q9BZ83, Q9BZ84, Q9BZ85, Q9BZ86, Q9BZ87, Q9BZ88	Gene names	ZAN
Domain Architecture
Description	Zonadhesin precursor.

NELL1_HUMAN
NC score	0.102479 (rank : 79)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	87	Target Neighborhood Hits	451	Shared Neighborhood Hits	35
SwissProt Accessions	Q92832, Q9Y472	Gene names	NELL1, NRP1
Domain Architecture
Description	Protein kinase C-binding protein NELL1 precursor (NEL-like protein 1) (Nel-related protein 1).

ATS2_HUMAN
NC score	0.101218 (rank : 80)	θ value	5.27518 (rank : 75)
Query Neighborhood Hits	87	Target Neighborhood Hits	179	Shared Neighborhood Hits	40
SwissProt Accessions	O95450	Gene names	ADAMTS2, PCINP, PCPNI
Domain Architecture
Description	ADAMTS-2 precursor (EC 3.4.24.14) (A disintegrin and metalloproteinase with thrombospondin motifs 2) (ADAM-TS 2) (ADAM-TS2) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen I N-proteinase) (PC I-NP) (Procollagen N-endopeptidase) (pNPI).

ATS6_HUMAN
NC score	0.100844 (rank : 81)	θ value	5.27518 (rank : 76)
Query Neighborhood Hits	87	Target Neighborhood Hits	141	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UKP5	Gene names	ADAMTS6
Domain Architecture
Description	ADAMTS-6 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 6) (ADAM-TS 6) (ADAM-TS6).

ATS13_HUMAN
NC score	0.099798 (rank : 82)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	87	Target Neighborhood Hits	238	Shared Neighborhood Hits	40
SwissProt Accessions	Q76LX8, Q6UY16, Q710F6, Q711T8, Q96L37, Q9H0G3	Gene names	ADAMTS13, C9orf8
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

ATS13_MOUSE
NC score	0.097738 (rank : 83)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	87	Target Neighborhood Hits	227	Shared Neighborhood Hits	40
SwissProt Accessions	Q769J6, Q76LW1	Gene names	Adamts13
Domain Architecture	No domain graphic available
Description	ADAMTS-13 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 13) (ADAM-TS 13) (ADAM-TS13) (von Willebrand factor-cleaving protease) (vWF-cleaving protease) (vWF-CP).

ATS8_MOUSE
NC score	0.093535 (rank : 84)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	87	Target Neighborhood Hits	139	Shared Neighborhood Hits	38
SwissProt Accessions	P57110	Gene names	Adamts8
Domain Architecture
Description	ADAMTS-8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2).

ATS8_HUMAN
NC score	0.092573 (rank : 85)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	87	Target Neighborhood Hits	145	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UP79, Q9NZS0	Gene names	ADAMTS8, METH2
Domain Architecture
Description	ADAMTS-8 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 8) (ADAM-TS 8) (ADAM-TS8) (METH-2) (METH- 8).

ATL1_MOUSE
NC score	0.091274 (rank : 86)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	87	Target Neighborhood Hits	80	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BLI0	Gene names	Adamtsl1
Domain Architecture
Description	ADAMTS-like protein 1 precursor (Punctin-1).

CI094_HUMAN
NC score	0.091120 (rank : 87)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	87	Target Neighborhood Hits	310	Shared Neighborhood Hits	44
SwissProt Accessions	Q496M8, Q496M6, Q5VZT8, Q8NAI9	Gene names	C9orf94
Domain Architecture	No domain graphic available
Description	Protein C9orf94 precursor.

NELL2_MOUSE
NC score	0.089298 (rank : 88)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	87	Target Neighborhood Hits	436	Shared Neighborhood Hits	33
SwissProt Accessions	Q61220	Gene names	Nell2, Mel91
Domain Architecture
Description	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (MEL91 protein).

ATS5_MOUSE
NC score	0.088852 (rank : 89)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	87	Target Neighborhood Hits	147	Shared Neighborhood Hits	37
SwissProt Accessions	Q9R001	Gene names	Adamts5
Domain Architecture
Description	ADAMTS-5 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 5) (ADAM-TS 5) (ADAM-TS5) (Aggrecanase-2) (ADMP-2) (Implantin).

ATS4_HUMAN
NC score	0.088825 (rank : 90)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	87	Target Neighborhood Hits	138	Shared Neighborhood Hits	33
SwissProt Accessions	O75173, Q5VTW2, Q6P4Q8, Q6UWA8, Q9UN83	Gene names	ADAMTS4, KIAA0688
Domain Architecture
Description	ADAMTS-4 precursor (EC 3.4.24.82) (A disintegrin and metalloproteinase with thrombospondin motifs 4) (ADAM-TS 4) (ADAM-TS4) (Aggrecanase-1) (ADMP-1).

NELL2_HUMAN
NC score	0.088794 (rank : 91)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	87	Target Neighborhood Hits	449	Shared Neighborhood Hits	32
SwissProt Accessions	Q99435	Gene names	NELL2, NRP2
Domain Architecture
Description	Protein kinase C-binding protein NELL2 precursor (NEL-like protein 2) (Nel-related protein 2).

ATS4_MOUSE
NC score	0.088517 (rank : 92)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	87	Target Neighborhood Hits	145	Shared Neighborhood Hits	33
SwissProt Accessions	Q8BNJ2, Q8K384	Gene names	Adamts4
Domain Architecture	No domain graphic available
Description	ADAMTS-4 precursor (EC 3.4.24.82) (A disintegrin and metalloproteinase with thrombospondin motifs 4) (ADAM-TS 4) (ADAM-TS4) (Aggrecanase-1).

LCE4A_HUMAN
NC score	0.085953 (rank : 93)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	87	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	Q5TA78	Gene names	LCE4A, LEP8, SPRL4A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 4A (Late envelope protein 8) (Small proline-rich-like epidermal differentiation complex protein 4A).

ATS5_HUMAN
NC score	0.085215 (rank : 94)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	87	Target Neighborhood Hits	141	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UNA0, Q9UKP2	Gene names	ADAMTS5, ADAMTS11, ADMP2
Domain Architecture
Description	ADAMTS-5 precursor (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 5) (ADAM-TS 5) (ADAM-TS5) (Aggrecanase-2) (ADMP-2) (ADAM-TS 11).

PROP_MOUSE
NC score	0.079740 (rank : 95)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	87	Target Neighborhood Hits	165	Shared Neighborhood Hits	37
SwissProt Accessions	P11680, Q3TB98, Q3U779	Gene names	Cfp, Pfc
Domain Architecture	No domain graphic available
Description	Properdin precursor (Factor P).

MCSP_MOUSE
NC score	0.079144 (rank : 96)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	87	Target Neighborhood Hits	108	Shared Neighborhood Hits	15
SwissProt Accessions	P15265, O70613, Q6P8N3	Gene names	Smcp, Mcs, Mcsp
Domain Architecture	No domain graphic available
Description	Sperm mitochondrial-associated cysteine-rich protein.

PROP_HUMAN
NC score	0.078719 (rank : 97)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	87	Target Neighborhood Hits	126	Shared Neighborhood Hits	35
SwissProt Accessions	P27918, O15134, O15135, O15136, O75826	Gene names	CFP, PFC
Domain Architecture
Description	Properdin precursor (Factor P).

SEM5A_HUMAN
NC score	0.076280 (rank : 98)	θ value	4.03905 (rank : 73)
Query Neighborhood Hits	87	Target Neighborhood Hits	177	Shared Neighborhood Hits	45
SwissProt Accessions	Q13591, O60408, Q1RLL9	Gene names	SEMA5A, SEMAF
Domain Architecture
Description	Semaphorin-5A precursor (Semaphorin F) (Sema F).

KR104_HUMAN
NC score	0.075576 (rank : 99)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	87	Target Neighborhood Hits	313	Shared Neighborhood Hits	34
SwissProt Accessions	P60372	Gene names	KRTAP10-4, KAP10.4, KAP18-4, KRTAP10.4, KRTAP18-4, KRTAP18.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-4 (Keratin-associated protein 10.4) (High sulfur keratin-associated protein 10.4) (Keratin-associated protein 18-4) (Keratin-associated protein 18.4).

BAI1_MOUSE
NC score	0.075484 (rank : 100)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	87	Target Neighborhood Hits	340	Shared Neighborhood Hits	43
SwissProt Accessions	Q3UHD1, Q3UH36, Q8CGM0	Gene names	Bai1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1 precursor.

SEM5A_MOUSE
NC score	0.074090 (rank : 101)	θ value	4.03905 (rank : 74)
Query Neighborhood Hits	87	Target Neighborhood Hits	162	Shared Neighborhood Hits	45
SwissProt Accessions	Q62217	Gene names	Sema5a, Semaf, SemF
Domain Architecture
Description	Semaphorin-5A precursor (Semaphorin F) (Sema F).

BAI1_HUMAN
NC score	0.072139 (rank : 102)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	87	Target Neighborhood Hits	375	Shared Neighborhood Hits	42
SwissProt Accessions	O14514	Gene names	BAI1
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 1 precursor.

CO1A1_MOUSE
NC score	0.070485 (rank : 103)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	87	Target Neighborhood Hits	457	Shared Neighborhood Hits	26
SwissProt Accessions	P11087, Q53WT0, Q60635, Q61367, Q61427, Q63919, Q6PCL3, Q810J9	Gene names	Col1a1, Cola1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

GRN_MOUSE
NC score	0.070298 (rank : 104)	θ value	6.88961 (rank : 80)
Query Neighborhood Hits	87	Target Neighborhood Hits	248	Shared Neighborhood Hits	26
SwissProt Accessions	P28798	Gene names	Grn
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) (PC cell-derived growth factor) (PCDGF) [Contains: Acrogranin; Granulin-1; Granulin-2; Granulin-3; Granulin-4; Granulin-5; Granulin-6; Granulin-7].

TECTA_MOUSE
NC score	0.070078 (rank : 105)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	87	Target Neighborhood Hits	244	Shared Neighborhood Hits	23
SwissProt Accessions	O08523	Gene names	Tecta
Domain Architecture
Description	Alpha-tectorin precursor.

LCE1E_HUMAN
NC score	0.069289 (rank : 106)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	87	Target Neighborhood Hits	53	Shared Neighborhood Hits	16
SwissProt Accessions	Q5T753	Gene names	LCE1E, LEP5
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1E (Late envelope protein 5).

BAI2_MOUSE
NC score	0.068927 (rank : 107)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	87	Target Neighborhood Hits	323	Shared Neighborhood Hits	43
SwissProt Accessions	Q8CGM1, Q3TYC8, Q3UN11, Q3UNE2, Q6PGN0	Gene names	Bai2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 2 precursor.

BAI3_MOUSE
NC score	0.068868 (rank : 108)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	87	Target Neighborhood Hits	250	Shared Neighborhood Hits	42
SwissProt Accessions	Q80ZF8	Gene names	Bai3
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

CO6_HUMAN
NC score	0.068792 (rank : 109)	θ value	3.0926 (rank : 64)
Query Neighborhood Hits	87	Target Neighborhood Hits	331	Shared Neighborhood Hits	44
SwissProt Accessions	P13671	Gene names	C6
Domain Architecture
Description	Complement component C6 precursor.

BAI2_HUMAN
NC score	0.068675 (rank : 110)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	87	Target Neighborhood Hits	332	Shared Neighborhood Hits	42
SwissProt Accessions	O60241, Q5T6K0, Q8NGW8	Gene names	BAI2
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 2 precursor.

HTRA2_MOUSE
NC score	0.068044 (rank : 111)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	87	Target Neighborhood Hits	29	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JIY5, Q9R108	Gene names	Htra2, Omi, Prss25
Domain Architecture
Description	Serine protease HTRA2, mitochondrial precursor (EC 3.4.21.-) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine proteinase OMI).

HTRA2_HUMAN
NC score	0.067841 (rank : 112)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	87	Target Neighborhood Hits	30	Shared Neighborhood Hits	5
SwissProt Accessions	O43464, Q9HBZ4, Q9P0Y3, Q9P0Y4	Gene names	HTRA2, OMI, PRSS25
Domain Architecture
Description	Serine protease HTRA2, mitochondrial precursor (EC 3.4.21.-) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine proteinase OMI).

TECTA_HUMAN
NC score	0.067031 (rank : 113)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	87	Target Neighborhood Hits	239	Shared Neighborhood Hits	24
SwissProt Accessions	O75443	Gene names	TECTA
Domain Architecture
Description	Alpha-tectorin precursor.

BAI3_HUMAN
NC score	0.065298 (rank : 114)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	87	Target Neighborhood Hits	246	Shared Neighborhood Hits	39
SwissProt Accessions	O60242, O60297	Gene names	BAI3, KIAA0550
Domain Architecture
Description	Brain-specific angiogenesis inhibitor 3 precursor.

SEM5B_MOUSE
NC score	0.063823 (rank : 115)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	87	Target Neighborhood Hits	190	Shared Neighborhood Hits	43
SwissProt Accessions	Q60519	Gene names	Sema5b, Semag, SemG
Domain Architecture
Description	Semaphorin-5B precursor (Semaphorin G) (Sema G).

KR107_HUMAN
NC score	0.062154 (rank : 116)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	87	Target Neighborhood Hits	330	Shared Neighborhood Hits	33
SwissProt Accessions	P60409, Q70LJ2	Gene names	KRTAP10-7, KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-7 (Keratin-associated protein 10.7) (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7).

SOSD1_HUMAN
NC score	0.061711 (rank : 117)	θ value	6.88961 (rank : 82)
Query Neighborhood Hits	87	Target Neighborhood Hits	14	Shared Neighborhood Hits	9
SwissProt Accessions	Q6X4U4, Q96HJ7, Q9Y3U3	Gene names	SOSTDC1, USAG1
Domain Architecture	No domain graphic available
Description	Sclerostin domain-containing protein 1 precursor (Ectodermal BMP inhibitor) (Ectodin) (Uterine sensitization-associated gene 1 protein) (USAG-1).

THSD1_MOUSE
NC score	0.060983 (rank : 118)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	87	Target Neighborhood Hits	153	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JM61, Q8C7Q9	Gene names	Thsd1, Tmtsp
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

THSD1_HUMAN
NC score	0.060965 (rank : 119)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	87	Target Neighborhood Hits	136	Shared Neighborhood Hits	34
SwissProt Accessions	Q9NS62, Q6P3U1, Q6UXZ2	Gene names	THSD1, TMTSP
Domain Architecture	No domain graphic available
Description	Thrombospondin type-1 domain-containing protein 1 precursor (Transmembrane molecule with thrombospondin module).

SEM5B_HUMAN
NC score	0.060320 (rank : 120)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	87	Target Neighborhood Hits	178	Shared Neighborhood Hits	44
SwissProt Accessions	Q9P283, Q6UY12	Gene names	SEMA5B, KIAA1445
Domain Architecture
Description	Semaphorin-5B precursor.

SOSD1_MOUSE
NC score	0.060039 (rank : 121)	θ value	6.88961 (rank : 83)
Query Neighborhood Hits	87	Target Neighborhood Hits	14	Shared Neighborhood Hits	9
SwissProt Accessions	Q9CQN4, Q8CF09	Gene names	Sostdc1, Sostl, Usag1
Domain Architecture	No domain graphic available
Description	Sclerostin domain-containing protein 1 precursor (Ectodermal BMP inhibitor) (Ectodin) (Uterine sensitization-associated gene 1 protein) (USAG-1) (Sclerostin-like protein).

LCE1C_HUMAN
NC score	0.059387 (rank : 122)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	87	Target Neighborhood Hits	65	Shared Neighborhood Hits	16
SwissProt Accessions	Q5T751	Gene names	LCE1C, LEP3
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1C (Late envelope protein 3).

RECK_HUMAN
NC score	0.059296 (rank : 123)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	87	Target Neighborhood Hits	189	Shared Neighborhood Hits	32
SwissProt Accessions	O95980, Q8WX37	Gene names	RECK
Domain Architecture
Description	Reversion-inducing cysteine-rich protein with Kazal motifs precursor (hRECK) (Suppressor of tumorigenicity 15) (ST15).

RECK_MOUSE
NC score	0.058107 (rank : 124)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	87	Target Neighborhood Hits	158	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Z0J1	Gene names	Reck
Domain Architecture	No domain graphic available
Description	Reversion-inducing cysteine-rich protein with Kazal motifs precursor (mRECK).

LCE2B_HUMAN
NC score	0.054957 (rank : 125)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	87	Target Neighborhood Hits	50	Shared Neighborhood Hits	9
SwissProt Accessions	O14633	Gene names	LCE2B, LEP10, SPRL1B, XP5
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2B (Late envelope protein 10) (Small proline-rich-like epidermal differentiation complex protein 1B) (Skin- specific protein Xp5).

LCE2D_HUMAN
NC score	0.053376 (rank : 126)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	87	Target Neighborhood Hits	50	Shared Neighborhood Hits	11
SwissProt Accessions	Q5TA82	Gene names	LCE2D, LEP12, SPRL1A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2D (Late envelope protein 12) (Small proline-rich-like epidermal differentiation complex protein 1A).

SLIT2_HUMAN
NC score	0.052906 (rank : 127)	θ value	0.279714 (rank : 35)
Query Neighborhood Hits	87	Target Neighborhood Hits	708	Shared Neighborhood Hits	31
SwissProt Accessions	O94813, O95710, Q9Y5Q7	Gene names	SLIT2, SLIL3
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

GRN_HUMAN
NC score	0.052375 (rank : 128)	θ value	3.0926 (rank : 67)
Query Neighborhood Hits	87	Target Neighborhood Hits	268	Shared Neighborhood Hits	25
SwissProt Accessions	P28799, P23781, P23782, P23783, P23784, Q9BWE7, Q9UCH0	Gene names	GRN
Domain Architecture
Description	Granulins precursor (Proepithelin) (PEPI) [Contains: Acrogranin; Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Granulin B); Granulin-4 (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)].

SLIT2_MOUSE
NC score	0.052342 (rank : 129)	θ value	0.279714 (rank : 36)
Query Neighborhood Hits	87	Target Neighborhood Hits	684	Shared Neighborhood Hits	27
SwissProt Accessions	Q9R1B9, Q9Z166	Gene names	Slit2
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

CHRD_HUMAN
NC score	0.052246 (rank : 130)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	87	Target Neighborhood Hits	102	Shared Neighborhood Hits	18
SwissProt Accessions	Q9H2X0, O95254, Q6UW83, Q9H2D3, Q9H2W8, Q9H2W9, Q9P0Z2, Q9P0Z3, Q9P0Z4, Q9P0Z5	Gene names	CHRD
Domain Architecture
Description	Chordin precursor.

LCE1B_HUMAN
NC score	0.052087 (rank : 131)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	87	Target Neighborhood Hits	58	Shared Neighborhood Hits	16
SwissProt Accessions	Q5T7P3	Gene names	LCE1B, LEP2, SPRL2A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1B (Late envelope protein 2) (Small proline-rich-like epidermal differentiation complex protein 2A).

SREC_HUMAN
NC score	0.051752 (rank : 132)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	87	Target Neighborhood Hits	645	Shared Neighborhood Hits	35
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

LCE1F_HUMAN
NC score	0.051393 (rank : 133)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	87	Target Neighborhood Hits	48	Shared Neighborhood Hits	12
SwissProt Accessions	Q5T754	Gene names	LCE1F, LEP6
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1F (Late envelope protein 6).

HMCN1_HUMAN
NC score	0.051370 (rank : 134)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	87	Target Neighborhood Hits	983	Shared Neighborhood Hits	62
SwissProt Accessions	Q96RW7, Q5TYR7, Q96DN3, Q96DN8, Q96SC3	Gene names	HMCN1, FIBL6
Domain Architecture	No domain graphic available
Description	Hemicentin-1 precursor (Fibulin-6) (FIBL-6).

MEGF6_HUMAN
NC score	0.050980 (rank : 135)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	87	Target Neighborhood Hits	671	Shared Neighborhood Hits	50
SwissProt Accessions	O75095, Q5VV39	Gene names	MEGF6, EGFL3, KIAA0815
Domain Architecture	No domain graphic available
Description	Multiple epidermal growth factor-like domains 6 precursor (EGF-like domain-containing protein 3) (Multiple EGF-like domain protein 3).

KR106_HUMAN
NC score	0.050712 (rank : 136)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	87	Target Neighborhood Hits	347	Shared Neighborhood Hits	34
SwissProt Accessions	P60371	Gene names	KRTAP10-6, KAP10.6, KAP18-6, KRTAP10.6, KRTAP18-6, KRTAP18.6
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-6 (Keratin-associated protein 10.6) (High sulfur keratin-associated protein 10.6) (Keratin-associated protein 18-6) (Keratin-associated protein 18.6).

RSPO4_HUMAN
NC score	0.050098 (rank : 137)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	87	Target Neighborhood Hits	110	Shared Neighborhood Hits	24
SwissProt Accessions	Q2I0M5, Q9UGB2	Gene names	RSPO4, C20orf182
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (hRspo4).

LCE2C_HUMAN
NC score	0.050038 (rank : 138)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	87	Target Neighborhood Hits	53	Shared Neighborhood Hits	12
SwissProt Accessions	Q5TA81	Gene names	LCE2C, LEP11
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2C (Late envelope protein 11).

TRBM_HUMAN
NC score	0.037423 (rank : 139)	θ value	8.99809 (rank : 86)
Query Neighborhood Hits	87	Target Neighborhood Hits	339	Shared Neighborhood Hits	26
SwissProt Accessions	P07204, Q9UC32	Gene names	THBD, THRM
Domain Architecture
Description	Thrombomodulin precursor (TM) (Fetomodulin) (CD141 antigen).

CO1A1_HUMAN
NC score	0.035582 (rank : 140)	θ value	1.38821 (rank : 56)
Query Neighborhood Hits	87	Target Neighborhood Hits	475	Shared Neighborhood Hits	21
SwissProt Accessions	P02452, P78441, Q13896, Q13902, Q13903, Q14037, Q14992, Q15176, Q15201, Q16050, Q7KZ30, Q7KZ34, Q8IVI5, Q9UML6, Q9UMM7	Gene names	COL1A1
Domain Architecture
Description	Collagen alpha-1(I) chain precursor.

NOTC4_MOUSE
NC score	0.034380 (rank : 141)	θ value	0.813845 (rank : 51)
Query Neighborhood Hits	87	Target Neighborhood Hits	872	Shared Neighborhood Hits	34
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

SLIT1_HUMAN
NC score	0.032041 (rank : 142)	θ value	0.365318 (rank : 40)
Query Neighborhood Hits	87	Target Neighborhood Hits	700	Shared Neighborhood Hits	24
SwissProt Accessions	O75093, Q8WWZ2, Q9UIL7	Gene names	SLIT1, KIAA0813, MEGF4, SLIL1
Domain Architecture
Description	Slit homolog 1 protein precursor (Slit-1) (Multiple epidermal growth factor-like domains 4).

KRA99_HUMAN
NC score	0.029407 (rank : 143)	θ value	3.0926 (rank : 68)
Query Neighborhood Hits	87	Target Neighborhood Hits	173	Shared Neighborhood Hits	19
SwissProt Accessions	Q9BYP9	Gene names	KRTAP9-9, KAP9.9, KRTAP9.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-9 (Keratin-associated protein 9.9) (Ultrahigh sulfur keratin-associated protein 9.9).

GFRA2_MOUSE
NC score	0.021752 (rank : 144)	θ value	2.36792 (rank : 62)
Query Neighborhood Hits	87	Target Neighborhood Hits	25	Shared Neighborhood Hits	4
SwissProt Accessions	O08842	Gene names	Gfra2, Gdnfrb, Trnr2
Domain Architecture
Description	GDNF family receptor alpha-2 precursor (GFR-alpha-2) (Neurturin receptor alpha) (NTNR-alpha) (NRTNR-alpha) (TGF-beta-related neurotrophic factor receptor 2) (GDNF receptor beta) (GDNFR-beta).

GFRA2_HUMAN
NC score	0.019541 (rank : 145)	θ value	5.27518 (rank : 78)
Query Neighborhood Hits	87	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	O00451, O15316, O15328, Q7Z5C2	Gene names	GFRA2, GDNFRB, RETL2, TRNR2
Domain Architecture
Description	GDNF family receptor alpha-2 precursor (GFR-alpha-2) (Neurturin receptor alpha) (NTNR-alpha) (NRTNR-alpha) (TGF-beta-related neurotrophic factor receptor 2) (GDNF receptor beta) (GDNFR-beta) (RET ligand 2).