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Network neighborhood for query Sequence : HTRA2_HUMAN

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HTRA2_HUMAN
SwissProt Accessions	O43464, Q9HBZ4, Q9P0Y3, Q9P0Y4	Gene names	HTRA2, OMI, PRSS25
Domain Architecture
Description	Serine protease HTRA2, mitochondrial precursor (EC 3.4.21.-) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine proteinase OMI).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

HTRA2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	30	Target Neighborhood Hits	30	Shared Neighborhood Hits	30
SwissProt Accessions	O43464, Q9HBZ4, Q9P0Y3, Q9P0Y4	Gene names	HTRA2, OMI, PRSS25
Domain Architecture
Description	Serine protease HTRA2, mitochondrial precursor (EC 3.4.21.-) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine proteinase OMI).

HTRA2_MOUSE
θ value	7.71569e-185 (rank : 2)	NC score	0.997314 (rank : 2)
Query Neighborhood Hits	30	Target Neighborhood Hits	29	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JIY5, Q9R108	Gene names	Htra2, Omi, Prss25
Domain Architecture
Description	Serine protease HTRA2, mitochondrial precursor (EC 3.4.21.-) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine proteinase OMI).

HTRA3_HUMAN
θ value	1.06975e-93 (rank : 3)	NC score	0.907065 (rank : 4)
Query Neighborhood Hits	30	Target Neighborhood Hits	152	Shared Neighborhood Hits	17
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

HTRA3_MOUSE
θ value	5.86991e-92 (rank : 4)	NC score	0.902841 (rank : 5)
Query Neighborhood Hits	30	Target Neighborhood Hits	156	Shared Neighborhood Hits	18
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

HTRA1_HUMAN
θ value	1.88829e-90 (rank : 5)	NC score	0.868504 (rank : 7)
Query Neighborhood Hits	30	Target Neighborhood Hits	155	Shared Neighborhood Hits	16
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

HTRA1_MOUSE
θ value	1.03614e-88 (rank : 6)	NC score	0.871812 (rank : 6)
Query Neighborhood Hits	30	Target Neighborhood Hits	140	Shared Neighborhood Hits	15
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

HTRA4_HUMAN
θ value	1.49966e-79 (rank : 7)	NC score	0.910634 (rank : 3)
Query Neighborhood Hits	30	Target Neighborhood Hits	119	Shared Neighborhood Hits	13
SwissProt Accessions	P83105, Q542Z4, Q6PF13	Gene names	HTRA4
Domain Architecture	No domain graphic available
Description	Probable serine protease HTRA4 precursor (EC 3.4.21.-).

PDZ11_HUMAN
θ value	0.00175202 (rank : 8)	NC score	0.151030 (rank : 18)
Query Neighborhood Hits	30	Target Neighborhood Hits	160	Shared Neighborhood Hits	21
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZ11_MOUSE
θ value	0.00175202 (rank : 9)	NC score	0.149079 (rank : 19)
Query Neighborhood Hits	30	Target Neighborhood Hits	154	Shared Neighborhood Hits	20
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

LAP4_MOUSE
θ value	0.125558 (rank : 10)	NC score	0.044800 (rank : 73)
Query Neighborhood Hits	30	Target Neighborhood Hits	590	Shared Neighborhood Hits	23
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

LAP4_HUMAN
θ value	0.163984 (rank : 11)	NC score	0.049461 (rank : 70)
Query Neighborhood Hits	30	Target Neighborhood Hits	608	Shared Neighborhood Hits	23
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

PDLI3_HUMAN
θ value	0.365318 (rank : 12)	NC score	0.052437 (rank : 65)
Query Neighborhood Hits	30	Target Neighborhood Hits	199	Shared Neighborhood Hits	15
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

PDZD1_HUMAN
θ value	0.365318 (rank : 13)	NC score	0.103750 (rank : 26)
Query Neighborhood Hits	30	Target Neighborhood Hits	190	Shared Neighborhood Hits	21
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

BHLH4_HUMAN
θ value	0.47712 (rank : 14)	NC score	0.025331 (rank : 77)
Query Neighborhood Hits	30	Target Neighborhood Hits	70	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NDY6	Gene names	BHLHB4
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 4 (bHLHB4).

PDLI2_MOUSE
θ value	0.62314 (rank : 15)	NC score	0.052918 (rank : 63)
Query Neighborhood Hits	30	Target Neighborhood Hits	220	Shared Neighborhood Hits	17
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

DLG5_HUMAN
θ value	0.813845 (rank : 16)	NC score	0.031010 (rank : 75)
Query Neighborhood Hits	30	Target Neighborhood Hits	1088	Shared Neighborhood Hits	18
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

PDLI3_MOUSE
θ value	1.06291 (rank : 17)	NC score	0.046466 (rank : 72)
Query Neighborhood Hits	30	Target Neighborhood Hits	197	Shared Neighborhood Hits	14
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

AN30A_HUMAN
θ value	1.38821 (rank : 18)	NC score	0.006183 (rank : 83)
Query Neighborhood Hits	30	Target Neighborhood Hits	1119	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).

RGS12_HUMAN
θ value	1.38821 (rank : 19)	NC score	0.030249 (rank : 76)
Query Neighborhood Hits	30	Target Neighborhood Hits	333	Shared Neighborhood Hits	17
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

PDZD1_MOUSE
θ value	1.81305 (rank : 20)	NC score	0.102582 (rank : 27)
Query Neighborhood Hits	30	Target Neighborhood Hits	191	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

GRIP2_HUMAN
θ value	3.0926 (rank : 21)	NC score	0.048989 (rank : 71)
Query Neighborhood Hits	30	Target Neighborhood Hits	256	Shared Neighborhood Hits	21
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

PDLI2_HUMAN
θ value	3.0926 (rank : 22)	NC score	0.042595 (rank : 74)
Query Neighborhood Hits	30	Target Neighborhood Hits	245	Shared Neighborhood Hits	16
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

TROAP_HUMAN
θ value	3.0926 (rank : 23)	NC score	0.021755 (rank : 78)
Query Neighborhood Hits	30	Target Neighborhood Hits	258	Shared Neighborhood Hits	3
SwissProt Accessions	Q12815	Gene names	TROAP
Domain Architecture	No domain graphic available
Description	Trophinin-associated protein (Tastin) (Trophinin-assisting protein).

CO5_MOUSE
θ value	5.27518 (rank : 24)	NC score	0.008330 (rank : 82)
Query Neighborhood Hits	30	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	P06684	Gene names	C5, Hc
Domain Architecture
Description	Complement C5 precursor (Hemolytic complement) [Contains: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain].

PDZD3_HUMAN
θ value	5.27518 (rank : 25)	NC score	0.084996 (rank : 35)
Query Neighborhood Hits	30	Target Neighborhood Hits	180	Shared Neighborhood Hits	22
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

SHAN1_HUMAN
θ value	5.27518 (rank : 26)	NC score	0.016806 (rank : 79)
Query Neighborhood Hits	30	Target Neighborhood Hits	1041	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

CREG2_HUMAN
θ value	8.99809 (rank : 27)	NC score	0.015607 (rank : 80)
Query Neighborhood Hits	30	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IUH2, Q86X03, Q8N540, Q8N9E3	Gene names	CREG2
Domain Architecture	No domain graphic available
Description	Protein CREG2 precursor.

DACT1_HUMAN
θ value	8.99809 (rank : 28)	NC score	0.009451 (rank : 81)
Query Neighborhood Hits	30	Target Neighborhood Hits	228	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NYF0, Q86TY0	Gene names	DACT1, DPR1, HNG3
Domain Architecture	No domain graphic available
Description	Dapper homolog 1 (hDPR1) (Heptacellular carcinoma novel gene 3 protein).

NHRF2_HUMAN
θ value	8.99809 (rank : 29)	NC score	0.052766 (rank : 64)
Query Neighborhood Hits	30	Target Neighborhood Hits	197	Shared Neighborhood Hits	19
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

SEM3B_HUMAN
θ value	8.99809 (rank : 30)	NC score	0.002634 (rank : 84)
Query Neighborhood Hits	30	Target Neighborhood Hits	76	Shared Neighborhood Hits	2
SwissProt Accessions	Q13214, Q8TB71, Q8TDV7, Q93018, Q96GX0	Gene names	SEMA3B, SEMA5
Domain Architecture
Description	Semaphorin-3B precursor (Semaphorin V) (Sema V) (Sema A(V)).

CRIM1_HUMAN
θ value	θ > 10 (rank : 31)	NC score	0.079124 (rank : 40)
Query Neighborhood Hits	30	Target Neighborhood Hits	362	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

CTGF_HUMAN
θ value	θ > 10 (rank : 32)	NC score	0.076179 (rank : 42)
Query Neighborhood Hits	30	Target Neighborhood Hits	128	Shared Neighborhood Hits	5
SwissProt Accessions	P29279, Q96QX2	Gene names	CTGF, CCN2, HCS24
Domain Architecture
Description	Connective tissue growth factor precursor (Hypertrophic chondrocyte- specific protein 24).

CTGF_MOUSE
θ value	θ > 10 (rank : 33)	NC score	0.054782 (rank : 58)
Query Neighborhood Hits	30	Target Neighborhood Hits	124	Shared Neighborhood Hits	5
SwissProt Accessions	P29268, Q922U0	Gene names	Ctgf, Ccn2, Fisp-12, Fisp12, Hcs24
Domain Architecture
Description	Connective tissue growth factor precursor (Protein FISP-12) (Hypertrophic chondrocyte-specific protein 24).

CYR61_HUMAN
θ value	θ > 10 (rank : 34)	NC score	0.089776 (rank : 31)
Query Neighborhood Hits	30	Target Neighborhood Hits	159	Shared Neighborhood Hits	5
SwissProt Accessions	O00622, O14934, O43775, Q9BZL7	Gene names	CYR61, CCN1, GIG1, IGFBP10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (Protein GIG1).

CYR61_MOUSE
θ value	θ > 10 (rank : 35)	NC score	0.089940 (rank : 30)
Query Neighborhood Hits	30	Target Neighborhood Hits	156	Shared Neighborhood Hits	5
SwissProt Accessions	P18406	Gene names	Cyr61, Ccn1, Igfbp10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (3CH61).

ESM1_HUMAN
θ value	θ > 10 (rank : 36)	NC score	0.195096 (rank : 17)
Query Neighborhood Hits	30	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NQ30, Q15330, Q96ES3	Gene names	ESM1
Domain Architecture	No domain graphic available
Description	Endothelial cell-specific molecule 1 precursor (ESM-1 secretory protein) (ESM-1).

ESM1_MOUSE
θ value	θ > 10 (rank : 37)	NC score	0.200043 (rank : 16)
Query Neighborhood Hits	30	Target Neighborhood Hits	107	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QYY7	Gene names	Esm1
Domain Architecture
Description	Endothelial cell-specific molecule 1 precursor (ESM-1 secretory protein) (ESM-1).

FSTL3_HUMAN
θ value	θ > 10 (rank : 38)	NC score	0.051601 (rank : 66)
Query Neighborhood Hits	30	Target Neighborhood Hits	162	Shared Neighborhood Hits	5
SwissProt Accessions	O95633	Gene names	FSTL3, FLRG
Domain Architecture
Description	Follistatin-related protein 3 precursor (Follistatin-like 3) (Follistatin-related gene protein).

FSTL3_MOUSE
θ value	θ > 10 (rank : 39)	NC score	0.050240 (rank : 69)
Query Neighborhood Hits	30	Target Neighborhood Hits	152	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EQC7	Gene names	Fstl3, Flrg
Domain Architecture
Description	Follistatin-related protein 3 precursor (Follistatin-like 3) (Follistatin-related gene protein).

GRASP_HUMAN
θ value	θ > 10 (rank : 40)	NC score	0.050636 (rank : 67)
Query Neighborhood Hits	30	Target Neighborhood Hits	147	Shared Neighborhood Hits	18
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

IBP1_HUMAN
θ value	θ > 10 (rank : 41)	NC score	0.057972 (rank : 53)
Query Neighborhood Hits	30	Target Neighborhood Hits	67	Shared Neighborhood Hits	2
SwissProt Accessions	P08833, Q8IYP5	Gene names	IGFBP1, IBP1
Domain Architecture
Description	Insulin-like growth factor-binding protein 1 precursor (IGFBP-1) (IBP- 1) (IGF-binding protein 1) (Placental protein 12) (PP12).

IBP1_MOUSE
θ value	θ > 10 (rank : 42)	NC score	0.094363 (rank : 29)
Query Neighborhood Hits	30	Target Neighborhood Hits	97	Shared Neighborhood Hits	5
SwissProt Accessions	P47876, Q61732	Gene names	Igfbp1, Igfbp-1
Domain Architecture
Description	Insulin-like growth factor-binding protein 1 precursor (IGFBP-1) (IBP- 1) (IGF-binding protein 1).

IBP2_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.085325 (rank : 34)
Query Neighborhood Hits	30	Target Neighborhood Hits	61	Shared Neighborhood Hits	5
SwissProt Accessions	P18065, Q14619, Q9UCL3	Gene names	IGFBP2, BP2
Domain Architecture
Description	Insulin-like growth factor-binding protein 2 precursor (IGFBP-2) (IBP- 2) (IGF-binding protein 2).

IBP2_MOUSE
θ value	θ > 10 (rank : 44)	NC score	0.073147 (rank : 45)
Query Neighborhood Hits	30	Target Neighborhood Hits	65	Shared Neighborhood Hits	5
SwissProt Accessions	P47877, Q61722	Gene names	Igfbp2, Igfbp-2
Domain Architecture
Description	Insulin-like growth factor-binding protein 2 precursor (IGFBP-2) (IBP- 2) (IGF-binding protein 2).

IBP3_HUMAN
θ value	θ > 10 (rank : 45)	NC score	0.109626 (rank : 23)
Query Neighborhood Hits	30	Target Neighborhood Hits	67	Shared Neighborhood Hits	5
SwissProt Accessions	P17936, Q2V509, Q6P1M6	Gene names	IGFBP3, IBP3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

IBP3_MOUSE
θ value	θ > 10 (rank : 46)	NC score	0.078539 (rank : 41)
Query Neighborhood Hits	30	Target Neighborhood Hits	60	Shared Neighborhood Hits	5
SwissProt Accessions	P47878	Gene names	Igfbp3, Igfbp-3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

IBP4_HUMAN
θ value	θ > 10 (rank : 47)	NC score	0.068316 (rank : 48)
Query Neighborhood Hits	30	Target Neighborhood Hits	52	Shared Neighborhood Hits	4
SwissProt Accessions	P22692	Gene names	IGFBP4, IBP4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

IBP4_MOUSE
θ value	θ > 10 (rank : 48)	NC score	0.064343 (rank : 51)
Query Neighborhood Hits	30	Target Neighborhood Hits	55	Shared Neighborhood Hits	4
SwissProt Accessions	P47879, O35666	Gene names	Igfbp4, Igfbp-4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

IBP5_HUMAN
θ value	θ > 10 (rank : 49)	NC score	0.081663 (rank : 39)
Query Neighborhood Hits	30	Target Neighborhood Hits	68	Shared Neighborhood Hits	5
SwissProt Accessions	P24593	Gene names	IGFBP5, IBP5
Domain Architecture
Description	Insulin-like growth factor-binding protein 5 precursor (IGFBP-5) (IBP- 5) (IGF-binding protein 5).

IBP5_MOUSE
θ value	θ > 10 (rank : 50)	NC score	0.081804 (rank : 38)
Query Neighborhood Hits	30	Target Neighborhood Hits	68	Shared Neighborhood Hits	5
SwissProt Accessions	Q07079	Gene names	Igfbp5, Igfbp-5
Domain Architecture
Description	Insulin-like growth factor-binding protein 5 precursor (IGFBP-5) (IBP- 5) (IGF-binding protein 5).

IBP7_HUMAN
θ value	θ > 10 (rank : 51)	NC score	0.266865 (rank : 9)
Query Neighborhood Hits	30	Target Neighborhood Hits	220	Shared Neighborhood Hits	5
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

IBP7_MOUSE
θ value	θ > 10 (rank : 52)	NC score	0.260231 (rank : 10)
Query Neighborhood Hits	30	Target Neighborhood Hits	230	Shared Neighborhood Hits	5
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

IPK1_HUMAN
θ value	θ > 10 (rank : 53)	NC score	0.069814 (rank : 47)
Query Neighborhood Hits	30	Target Neighborhood Hits	38	Shared Neighborhood Hits	4
SwissProt Accessions	P00995	Gene names	SPINK1, PSTI
Domain Architecture
Description	Pancreatic secretory trypsin inhibitor precursor (Tumor-associated trypsin inhibitor) (TATI) (Serine protease inhibitor Kazal-type 1).

ISK3_MOUSE
θ value	θ > 10 (rank : 54)	NC score	0.100268 (rank : 28)
Query Neighborhood Hits	30	Target Neighborhood Hits	36	Shared Neighborhood Hits	5
SwissProt Accessions	P09036, Q5M9M3	Gene names	Spink3
Domain Architecture
Description	Serine protease inhibitor Kazal-type 3 precursor (Prostatic secretory glycoprotein) (P12).

KAZD1_HUMAN
θ value	θ > 10 (rank : 55)	NC score	0.211163 (rank : 14)
Query Neighborhood Hits	30	Target Neighborhood Hits	248	Shared Neighborhood Hits	5
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

KAZD1_MOUSE
θ value	θ > 10 (rank : 56)	NC score	0.200632 (rank : 15)
Query Neighborhood Hits	30	Target Neighborhood Hits	281	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

LCE1A_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.141390 (rank : 20)
Query Neighborhood Hits	30	Target Neighborhood Hits	47	Shared Neighborhood Hits	2
SwissProt Accessions	Q5T7P2	Gene names	LCE1A, LEP1
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1A (Late envelope protein 1).

LCE1B_HUMAN
θ value	θ > 10 (rank : 58)	NC score	0.220881 (rank : 13)
Query Neighborhood Hits	30	Target Neighborhood Hits	58	Shared Neighborhood Hits	5
SwissProt Accessions	Q5T7P3	Gene names	LCE1B, LEP2, SPRL2A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1B (Late envelope protein 2) (Small proline-rich-like epidermal differentiation complex protein 2A).

LCE1C_HUMAN
θ value	θ > 10 (rank : 59)	NC score	0.252975 (rank : 11)
Query Neighborhood Hits	30	Target Neighborhood Hits	65	Shared Neighborhood Hits	5
SwissProt Accessions	Q5T751	Gene names	LCE1C, LEP3
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1C (Late envelope protein 3).

LCE1D_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.222357 (rank : 12)
Query Neighborhood Hits	30	Target Neighborhood Hits	44	Shared Neighborhood Hits	5
SwissProt Accessions	Q5T752	Gene names	LCE1D, LEP4
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1D (Late envelope protein 4).

LCE1E_HUMAN
θ value	θ > 10 (rank : 61)	NC score	0.274056 (rank : 8)
Query Neighborhood Hits	30	Target Neighborhood Hits	53	Shared Neighborhood Hits	5
SwissProt Accessions	Q5T753	Gene names	LCE1E, LEP5
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1E (Late envelope protein 5).

LCE1F_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.128137 (rank : 21)
Query Neighborhood Hits	30	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	Q5T754	Gene names	LCE1F, LEP6
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1F (Late envelope protein 6).

LCE2A_HUMAN
θ value	θ > 10 (rank : 63)	NC score	0.065420 (rank : 50)
Query Neighborhood Hits	30	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	Q5TA79	Gene names	LCE2A, LEP9
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2A (Late envelope protein 9).

LCE2B_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.105883 (rank : 25)
Query Neighborhood Hits	30	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	O14633	Gene names	LCE2B, LEP10, SPRL1B, XP5
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2B (Late envelope protein 10) (Small proline-rich-like epidermal differentiation complex protein 1B) (Skin- specific protein Xp5).

LCE2C_HUMAN
θ value	θ > 10 (rank : 65)	NC score	0.086348 (rank : 33)
Query Neighborhood Hits	30	Target Neighborhood Hits	53	Shared Neighborhood Hits	3
SwissProt Accessions	Q5TA81	Gene names	LCE2C, LEP11
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2C (Late envelope protein 11).

LCE2D_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.107028 (rank : 24)
Query Neighborhood Hits	30	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q5TA82	Gene names	LCE2D, LEP12, SPRL1A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2D (Late envelope protein 12) (Small proline-rich-like epidermal differentiation complex protein 1A).

LCE4A_HUMAN
θ value	θ > 10 (rank : 67)	NC score	0.059949 (rank : 52)
Query Neighborhood Hits	30	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q5TA78	Gene names	LCE4A, LEP8, SPRL4A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 4A (Late envelope protein 8) (Small proline-rich-like epidermal differentiation complex protein 4A).

LCE5A_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.121863 (rank : 22)
Query Neighborhood Hits	30	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q5TCM9	Gene names	LCE5A, LEP18, SPRL5A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 5A (Late envelope protein 18) (Small proline-rich-like epidermal differentiation complex protein 5A).

NHERF_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.075536 (rank : 43)
Query Neighborhood Hits	30	Target Neighborhood Hits	190	Shared Neighborhood Hits	21
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NHERF_MOUSE
θ value	θ > 10 (rank : 70)	NC score	0.072360 (rank : 46)
Query Neighborhood Hits	30	Target Neighborhood Hits	195	Shared Neighborhood Hits	21
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NOV_HUMAN
θ value	θ > 10 (rank : 71)	NC score	0.083100 (rank : 37)
Query Neighborhood Hits	30	Target Neighborhood Hits	128	Shared Neighborhood Hits	5
SwissProt Accessions	P48745, Q96BY5	Gene names	NOV, CCN3, IGFBP9, NOVH
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

NOV_MOUSE
θ value	θ > 10 (rank : 72)	NC score	0.075418 (rank : 44)
Query Neighborhood Hits	30	Target Neighborhood Hits	130	Shared Neighborhood Hits	5
SwissProt Accessions	Q64299, Q8CA67	Gene names	Nov, Ccn3
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

PDZD3_MOUSE
θ value	θ > 10 (rank : 73)	NC score	0.084496 (rank : 36)
Query Neighborhood Hits	30	Target Neighborhood Hits	171	Shared Neighborhood Hits	21
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

RHPN1_HUMAN
θ value	θ > 10 (rank : 74)	NC score	0.057101 (rank : 55)
Query Neighborhood Hits	30	Target Neighborhood Hits	158	Shared Neighborhood Hits	21
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

RHPN1_MOUSE
θ value	θ > 10 (rank : 75)	NC score	0.053990 (rank : 59)
Query Neighborhood Hits	30	Target Neighborhood Hits	154	Shared Neighborhood Hits	20
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

TX1B3_HUMAN
θ value	θ > 10 (rank : 76)	NC score	0.055664 (rank : 56)
Query Neighborhood Hits	30	Target Neighborhood Hits	161	Shared Neighborhood Hits	19
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
θ value	θ > 10 (rank : 77)	NC score	0.055068 (rank : 57)
Query Neighborhood Hits	30	Target Neighborhood Hits	158	Shared Neighborhood Hits	19
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

USH1C_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.052961 (rank : 62)
Query Neighborhood Hits	30	Target Neighborhood Hits	327	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

USH1C_MOUSE
θ value	θ > 10 (rank : 79)	NC score	0.050617 (rank : 68)
Query Neighborhood Hits	30	Target Neighborhood Hits	557	Shared Neighborhood Hits	22
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

WHRN_HUMAN
θ value	θ > 10 (rank : 80)	NC score	0.053595 (rank : 61)
Query Neighborhood Hits	30	Target Neighborhood Hits	325	Shared Neighborhood Hits	21
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

WHRN_MOUSE
θ value	θ > 10 (rank : 81)	NC score	0.053721 (rank : 60)
Query Neighborhood Hits	30	Target Neighborhood Hits	412	Shared Neighborhood Hits	21
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

WISP2_HUMAN
θ value	θ > 10 (rank : 82)	NC score	0.087846 (rank : 32)
Query Neighborhood Hits	30	Target Neighborhood Hits	126	Shared Neighborhood Hits	5
SwissProt Accessions	O76076	Gene names	WISP2, CCN5, CT58, CTGFL
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L) (Connective tissue growth factor-related protein 58).

WISP2_MOUSE
θ value	θ > 10 (rank : 83)	NC score	0.057321 (rank : 54)
Query Neighborhood Hits	30	Target Neighborhood Hits	129	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z0G4, Q8CIC8	Gene names	Wisp2, Ccn5, Ctgfl
Domain Architecture
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L).

WISP3_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.067841 (rank : 49)
Query Neighborhood Hits	30	Target Neighborhood Hits	87	Shared Neighborhood Hits	5
SwissProt Accessions	O95389, Q6UXH6	Gene names	WISP3, CCN6
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 3 precursor (WISP-3).

Hits sorted by NC score

HTRA2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	30	Target Neighborhood Hits	30	Shared Neighborhood Hits	30
SwissProt Accessions	O43464, Q9HBZ4, Q9P0Y3, Q9P0Y4	Gene names	HTRA2, OMI, PRSS25
Domain Architecture
Description	Serine protease HTRA2, mitochondrial precursor (EC 3.4.21.-) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine proteinase OMI).

HTRA2_MOUSE
NC score	0.997314 (rank : 2)	θ value	7.71569e-185 (rank : 2)
Query Neighborhood Hits	30	Target Neighborhood Hits	29	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JIY5, Q9R108	Gene names	Htra2, Omi, Prss25
Domain Architecture
Description	Serine protease HTRA2, mitochondrial precursor (EC 3.4.21.-) (High temperature requirement protein A2) (HtrA2) (Omi stress-regulated endoprotease) (Serine proteinase OMI).

HTRA4_HUMAN
NC score	0.910634 (rank : 3)	θ value	1.49966e-79 (rank : 7)
Query Neighborhood Hits	30	Target Neighborhood Hits	119	Shared Neighborhood Hits	13
SwissProt Accessions	P83105, Q542Z4, Q6PF13	Gene names	HTRA4
Domain Architecture	No domain graphic available
Description	Probable serine protease HTRA4 precursor (EC 3.4.21.-).

HTRA3_HUMAN
NC score	0.907065 (rank : 4)	θ value	1.06975e-93 (rank : 3)
Query Neighborhood Hits	30	Target Neighborhood Hits	152	Shared Neighborhood Hits	17
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

HTRA3_MOUSE
NC score	0.902841 (rank : 5)	θ value	5.86991e-92 (rank : 4)
Query Neighborhood Hits	30	Target Neighborhood Hits	156	Shared Neighborhood Hits	18
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

HTRA1_MOUSE
NC score	0.871812 (rank : 6)	θ value	1.03614e-88 (rank : 6)
Query Neighborhood Hits	30	Target Neighborhood Hits	140	Shared Neighborhood Hits	15
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

HTRA1_HUMAN
NC score	0.868504 (rank : 7)	θ value	1.88829e-90 (rank : 5)
Query Neighborhood Hits	30	Target Neighborhood Hits	155	Shared Neighborhood Hits	16
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

LCE1E_HUMAN
NC score	0.274056 (rank : 8)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	30	Target Neighborhood Hits	53	Shared Neighborhood Hits	5
SwissProt Accessions	Q5T753	Gene names	LCE1E, LEP5
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1E (Late envelope protein 5).

IBP7_HUMAN
NC score	0.266865 (rank : 9)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	30	Target Neighborhood Hits	220	Shared Neighborhood Hits	5
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

IBP7_MOUSE
NC score	0.260231 (rank : 10)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	30	Target Neighborhood Hits	230	Shared Neighborhood Hits	5
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

LCE1C_HUMAN
NC score	0.252975 (rank : 11)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	30	Target Neighborhood Hits	65	Shared Neighborhood Hits	5
SwissProt Accessions	Q5T751	Gene names	LCE1C, LEP3
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1C (Late envelope protein 3).

LCE1D_HUMAN
NC score	0.222357 (rank : 12)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	30	Target Neighborhood Hits	44	Shared Neighborhood Hits	5
SwissProt Accessions	Q5T752	Gene names	LCE1D, LEP4
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1D (Late envelope protein 4).

LCE1B_HUMAN
NC score	0.220881 (rank : 13)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	30	Target Neighborhood Hits	58	Shared Neighborhood Hits	5
SwissProt Accessions	Q5T7P3	Gene names	LCE1B, LEP2, SPRL2A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1B (Late envelope protein 2) (Small proline-rich-like epidermal differentiation complex protein 2A).

KAZD1_HUMAN
NC score	0.211163 (rank : 14)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	30	Target Neighborhood Hits	248	Shared Neighborhood Hits	5
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

KAZD1_MOUSE
NC score	0.200632 (rank : 15)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	30	Target Neighborhood Hits	281	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

ESM1_MOUSE
NC score	0.200043 (rank : 16)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	30	Target Neighborhood Hits	107	Shared Neighborhood Hits	5
SwissProt Accessions	Q9QYY7	Gene names	Esm1
Domain Architecture
Description	Endothelial cell-specific molecule 1 precursor (ESM-1 secretory protein) (ESM-1).

ESM1_HUMAN
NC score	0.195096 (rank : 17)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	30	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NQ30, Q15330, Q96ES3	Gene names	ESM1
Domain Architecture	No domain graphic available
Description	Endothelial cell-specific molecule 1 precursor (ESM-1 secretory protein) (ESM-1).

PDZ11_HUMAN
NC score	0.151030 (rank : 18)	θ value	0.00175202 (rank : 8)
Query Neighborhood Hits	30	Target Neighborhood Hits	160	Shared Neighborhood Hits	21
SwissProt Accessions	Q5EBL8, Q6UWE1, Q9P0Q1	Gene names	PDZD11, PDZK11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

PDZ11_MOUSE
NC score	0.149079 (rank : 19)	θ value	0.00175202 (rank : 9)
Query Neighborhood Hits	30	Target Neighborhood Hits	154	Shared Neighborhood Hits	20
SwissProt Accessions	Q9CZG9	Gene names	Pdzd11, Pdzk11
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 11.

LCE1A_HUMAN
NC score	0.141390 (rank : 20)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	30	Target Neighborhood Hits	47	Shared Neighborhood Hits	2
SwissProt Accessions	Q5T7P2	Gene names	LCE1A, LEP1
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1A (Late envelope protein 1).

LCE1F_HUMAN
NC score	0.128137 (rank : 21)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	30	Target Neighborhood Hits	48	Shared Neighborhood Hits	3
SwissProt Accessions	Q5T754	Gene names	LCE1F, LEP6
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1F (Late envelope protein 6).

LCE5A_HUMAN
NC score	0.121863 (rank : 22)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	30	Target Neighborhood Hits	43	Shared Neighborhood Hits	3
SwissProt Accessions	Q5TCM9	Gene names	LCE5A, LEP18, SPRL5A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 5A (Late envelope protein 18) (Small proline-rich-like epidermal differentiation complex protein 5A).

IBP3_HUMAN
NC score	0.109626 (rank : 23)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	30	Target Neighborhood Hits	67	Shared Neighborhood Hits	5
SwissProt Accessions	P17936, Q2V509, Q6P1M6	Gene names	IGFBP3, IBP3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

LCE2D_HUMAN
NC score	0.107028 (rank : 24)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	30	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q5TA82	Gene names	LCE2D, LEP12, SPRL1A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2D (Late envelope protein 12) (Small proline-rich-like epidermal differentiation complex protein 1A).

LCE2B_HUMAN
NC score	0.105883 (rank : 25)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	30	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	O14633	Gene names	LCE2B, LEP10, SPRL1B, XP5
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2B (Late envelope protein 10) (Small proline-rich-like epidermal differentiation complex protein 1B) (Skin- specific protein Xp5).

PDZD1_HUMAN
NC score	0.103750 (rank : 26)	θ value	0.365318 (rank : 13)
Query Neighborhood Hits	30	Target Neighborhood Hits	190	Shared Neighborhood Hits	21
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PDZD1_MOUSE
NC score	0.102582 (rank : 27)	θ value	1.81305 (rank : 20)
Query Neighborhood Hits	30	Target Neighborhood Hits	191	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

ISK3_MOUSE
NC score	0.100268 (rank : 28)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	30	Target Neighborhood Hits	36	Shared Neighborhood Hits	5
SwissProt Accessions	P09036, Q5M9M3	Gene names	Spink3
Domain Architecture
Description	Serine protease inhibitor Kazal-type 3 precursor (Prostatic secretory glycoprotein) (P12).

IBP1_MOUSE
NC score	0.094363 (rank : 29)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	30	Target Neighborhood Hits	97	Shared Neighborhood Hits	5
SwissProt Accessions	P47876, Q61732	Gene names	Igfbp1, Igfbp-1
Domain Architecture
Description	Insulin-like growth factor-binding protein 1 precursor (IGFBP-1) (IBP- 1) (IGF-binding protein 1).

CYR61_MOUSE
NC score	0.089940 (rank : 30)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	30	Target Neighborhood Hits	156	Shared Neighborhood Hits	5
SwissProt Accessions	P18406	Gene names	Cyr61, Ccn1, Igfbp10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (3CH61).

CYR61_HUMAN
NC score	0.089776 (rank : 31)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	30	Target Neighborhood Hits	159	Shared Neighborhood Hits	5
SwissProt Accessions	O00622, O14934, O43775, Q9BZL7	Gene names	CYR61, CCN1, GIG1, IGFBP10
Domain Architecture
Description	Protein CYR61 precursor (Cysteine-rich, angiogenic inducer, 61) (Insulin-like growth factor-binding protein 10) (Protein GIG1).

WISP2_HUMAN
NC score	0.087846 (rank : 32)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	30	Target Neighborhood Hits	126	Shared Neighborhood Hits	5
SwissProt Accessions	O76076	Gene names	WISP2, CCN5, CT58, CTGFL
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L) (Connective tissue growth factor-related protein 58).

LCE2C_HUMAN
NC score	0.086348 (rank : 33)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	30	Target Neighborhood Hits	53	Shared Neighborhood Hits	3
SwissProt Accessions	Q5TA81	Gene names	LCE2C, LEP11
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2C (Late envelope protein 11).

IBP2_HUMAN
NC score	0.085325 (rank : 34)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	30	Target Neighborhood Hits	61	Shared Neighborhood Hits	5
SwissProt Accessions	P18065, Q14619, Q9UCL3	Gene names	IGFBP2, BP2
Domain Architecture
Description	Insulin-like growth factor-binding protein 2 precursor (IGFBP-2) (IBP- 2) (IGF-binding protein 2).

PDZD3_HUMAN
NC score	0.084996 (rank : 35)	θ value	5.27518 (rank : 25)
Query Neighborhood Hits	30	Target Neighborhood Hits	180	Shared Neighborhood Hits	22
SwissProt Accessions	Q86UT5, Q8N6R4, Q8NAW7, Q8NEX7, Q9H5Z3	Gene names	PDZD3, IKEPP, PDZK2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Intestinal and kidney-enriched PDZ protein) (Protein DLNB27).

PDZD3_MOUSE
NC score	0.084496 (rank : 36)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	30	Target Neighborhood Hits	171	Shared Neighborhood Hits	21
SwissProt Accessions	Q99MJ6, Q8BWE5	Gene names	Pdzd3, Pdzk2
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 3 (PDZ domain-containing protein 2) (Natrium-phosphate cotransporter IIa C-terminal-associated protein 2) (NaPi-Cap2).

NOV_HUMAN
NC score	0.083100 (rank : 37)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	30	Target Neighborhood Hits	128	Shared Neighborhood Hits	5
SwissProt Accessions	P48745, Q96BY5	Gene names	NOV, CCN3, IGFBP9, NOVH
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

IBP5_MOUSE
NC score	0.081804 (rank : 38)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	30	Target Neighborhood Hits	68	Shared Neighborhood Hits	5
SwissProt Accessions	Q07079	Gene names	Igfbp5, Igfbp-5
Domain Architecture
Description	Insulin-like growth factor-binding protein 5 precursor (IGFBP-5) (IBP- 5) (IGF-binding protein 5).

IBP5_HUMAN
NC score	0.081663 (rank : 39)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	30	Target Neighborhood Hits	68	Shared Neighborhood Hits	5
SwissProt Accessions	P24593	Gene names	IGFBP5, IBP5
Domain Architecture
Description	Insulin-like growth factor-binding protein 5 precursor (IGFBP-5) (IBP- 5) (IGF-binding protein 5).

CRIM1_HUMAN
NC score	0.079124 (rank : 40)	θ value	θ > 10 (rank : 31)
Query Neighborhood Hits	30	Target Neighborhood Hits	362	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

IBP3_MOUSE
NC score	0.078539 (rank : 41)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	30	Target Neighborhood Hits	60	Shared Neighborhood Hits	5
SwissProt Accessions	P47878	Gene names	Igfbp3, Igfbp-3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

CTGF_HUMAN
NC score	0.076179 (rank : 42)	θ value	θ > 10 (rank : 32)
Query Neighborhood Hits	30	Target Neighborhood Hits	128	Shared Neighborhood Hits	5
SwissProt Accessions	P29279, Q96QX2	Gene names	CTGF, CCN2, HCS24
Domain Architecture
Description	Connective tissue growth factor precursor (Hypertrophic chondrocyte- specific protein 24).

NHERF_HUMAN
NC score	0.075536 (rank : 43)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	30	Target Neighborhood Hits	190	Shared Neighborhood Hits	21
SwissProt Accessions	O14745, O43552, Q86WQ5	Gene names	SLC9A3R1, NHERF
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

NOV_MOUSE
NC score	0.075418 (rank : 44)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	30	Target Neighborhood Hits	130	Shared Neighborhood Hits	5
SwissProt Accessions	Q64299, Q8CA67	Gene names	Nov, Ccn3
Domain Architecture
Description	Protein NOV homolog precursor (NovH) (Nephroblastoma overexpressed gene protein homolog).

IBP2_MOUSE
NC score	0.073147 (rank : 45)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	30	Target Neighborhood Hits	65	Shared Neighborhood Hits	5
SwissProt Accessions	P47877, Q61722	Gene names	Igfbp2, Igfbp-2
Domain Architecture
Description	Insulin-like growth factor-binding protein 2 precursor (IGFBP-2) (IBP- 2) (IGF-binding protein 2).

NHERF_MOUSE
NC score	0.072360 (rank : 46)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	30	Target Neighborhood Hits	195	Shared Neighborhood Hits	21
SwissProt Accessions	P70441	Gene names	Slc9a3r1, Nherf
Domain Architecture
Description	Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory factor 1).

IPK1_HUMAN
NC score	0.069814 (rank : 47)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	30	Target Neighborhood Hits	38	Shared Neighborhood Hits	4
SwissProt Accessions	P00995	Gene names	SPINK1, PSTI
Domain Architecture
Description	Pancreatic secretory trypsin inhibitor precursor (Tumor-associated trypsin inhibitor) (TATI) (Serine protease inhibitor Kazal-type 1).

IBP4_HUMAN
NC score	0.068316 (rank : 48)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	30	Target Neighborhood Hits	52	Shared Neighborhood Hits	4
SwissProt Accessions	P22692	Gene names	IGFBP4, IBP4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

WISP3_HUMAN
NC score	0.067841 (rank : 49)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	30	Target Neighborhood Hits	87	Shared Neighborhood Hits	5
SwissProt Accessions	O95389, Q6UXH6	Gene names	WISP3, CCN6
Domain Architecture	No domain graphic available
Description	WNT1-inducible signaling pathway protein 3 precursor (WISP-3).

LCE2A_HUMAN
NC score	0.065420 (rank : 50)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	30	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	Q5TA79	Gene names	LCE2A, LEP9
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2A (Late envelope protein 9).

IBP4_MOUSE
NC score	0.064343 (rank : 51)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	30	Target Neighborhood Hits	55	Shared Neighborhood Hits	4
SwissProt Accessions	P47879, O35666	Gene names	Igfbp4, Igfbp-4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

LCE4A_HUMAN
NC score	0.059949 (rank : 52)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	30	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q5TA78	Gene names	LCE4A, LEP8, SPRL4A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 4A (Late envelope protein 8) (Small proline-rich-like epidermal differentiation complex protein 4A).

IBP1_HUMAN
NC score	0.057972 (rank : 53)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	30	Target Neighborhood Hits	67	Shared Neighborhood Hits	2
SwissProt Accessions	P08833, Q8IYP5	Gene names	IGFBP1, IBP1
Domain Architecture
Description	Insulin-like growth factor-binding protein 1 precursor (IGFBP-1) (IBP- 1) (IGF-binding protein 1) (Placental protein 12) (PP12).

WISP2_MOUSE
NC score	0.057321 (rank : 54)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	30	Target Neighborhood Hits	129	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z0G4, Q8CIC8	Gene names	Wisp2, Ccn5, Ctgfl
Domain Architecture
Description	WNT1-inducible signaling pathway protein 2 precursor (WISP-2) (Connective tissue growth factor-like protein) (CTGF-L).

RHPN1_HUMAN
NC score	0.057101 (rank : 55)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	30	Target Neighborhood Hits	158	Shared Neighborhood Hits	21
SwissProt Accessions	Q8TCX5, Q8TAV1	Gene names	RHPN1
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

TX1B3_HUMAN
NC score	0.055664 (rank : 56)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	30	Target Neighborhood Hits	161	Shared Neighborhood Hits	19
SwissProt Accessions	O14907, Q7LCQ4	Gene names	TAX1BP3, TIP1
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1) (Glutaminase-interacting protein 3).

TX1B3_MOUSE
NC score	0.055068 (rank : 57)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	30	Target Neighborhood Hits	158	Shared Neighborhood Hits	19
SwissProt Accessions	Q9DBG9	Gene names	Tax1bp3
Domain Architecture	No domain graphic available
Description	Tax1-binding protein 3 (Tax interaction protein 1) (TIP-1).

CTGF_MOUSE
NC score	0.054782 (rank : 58)	θ value	θ > 10 (rank : 33)
Query Neighborhood Hits	30	Target Neighborhood Hits	124	Shared Neighborhood Hits	5
SwissProt Accessions	P29268, Q922U0	Gene names	Ctgf, Ccn2, Fisp-12, Fisp12, Hcs24
Domain Architecture
Description	Connective tissue growth factor precursor (Protein FISP-12) (Hypertrophic chondrocyte-specific protein 24).

RHPN1_MOUSE
NC score	0.053990 (rank : 59)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	30	Target Neighborhood Hits	154	Shared Neighborhood Hits	20
SwissProt Accessions	Q61085	Gene names	Rhpn1, Grbp
Domain Architecture
Description	Rhophilin-1 (GTP-Rho-binding protein 1).

WHRN_MOUSE
NC score	0.053721 (rank : 60)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	30	Target Neighborhood Hits	412	Shared Neighborhood Hits	21
SwissProt Accessions	Q80VW5, Q80TC2, Q80VW4	Gene names	Whrn, Kiaa1526
Domain Architecture	No domain graphic available
Description	Whirlin.

WHRN_HUMAN
NC score	0.053595 (rank : 61)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	30	Target Neighborhood Hits	325	Shared Neighborhood Hits	21
SwissProt Accessions	Q9P202, Q96MZ9, Q9H9F4, Q9UFZ3	Gene names	WHRN, DFNB31, KIAA1526
Domain Architecture	No domain graphic available
Description	Whirlin (Autosomal recessive deafness type 31 protein).

USH1C_HUMAN
NC score	0.052961 (rank : 62)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	30	Target Neighborhood Hits	327	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y6N9, Q96B29, Q9UM04, Q9UM17, Q9UPC3	Gene names	USH1C, AIE75
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein) (Autoimmune enteropathy- related antigen AIE-75) (Antigen NY-CO-38/NY-CO-37) (PDZ-73 protein) (NY-REN-3 antigen).

PDLI2_MOUSE
NC score	0.052918 (rank : 63)	θ value	0.62314 (rank : 15)
Query Neighborhood Hits	30	Target Neighborhood Hits	220	Shared Neighborhood Hits	17
SwissProt Accessions	Q8R1G6	Gene names	Pdlim2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique).

NHRF2_HUMAN
NC score	0.052766 (rank : 64)	θ value	8.99809 (rank : 29)
Query Neighborhood Hits	30	Target Neighborhood Hits	197	Shared Neighborhood Hits	19
SwissProt Accessions	Q15599, O00272, O00556	Gene names	SLC9A3R2, NHERF2
Domain Architecture
Description	Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (Tyrosine kinase activator protein 1) (TKA-1) (SRY-interacting protein 1) (SIP- 1) (Solute carrier family 9 isoform A3 regulatory factor 2) (NHE3 kinase A regulatory protein E3KARP) (Sodium-hydrogen exchanger regulatory factor 2).

PDLI3_HUMAN
NC score	0.052437 (rank : 65)	θ value	0.365318 (rank : 12)
Query Neighborhood Hits	30	Target Neighborhood Hits	199	Shared Neighborhood Hits	15
SwissProt Accessions	Q53GG5, O43590, O60439, O60440, Q8N6Y6, Q9BVP4	Gene names	PDLIM3, ALP
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

FSTL3_HUMAN
NC score	0.051601 (rank : 66)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	30	Target Neighborhood Hits	162	Shared Neighborhood Hits	5
SwissProt Accessions	O95633	Gene names	FSTL3, FLRG
Domain Architecture
Description	Follistatin-related protein 3 precursor (Follistatin-like 3) (Follistatin-related gene protein).

GRASP_HUMAN
NC score	0.050636 (rank : 67)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	30	Target Neighborhood Hits	147	Shared Neighborhood Hits	18
SwissProt Accessions	Q7Z6J2, Q6PIF8, Q7Z741	Gene names	GRASP
Domain Architecture	No domain graphic available
Description	General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein).

USH1C_MOUSE
NC score	0.050617 (rank : 68)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	30	Target Neighborhood Hits	557	Shared Neighborhood Hits	22
SwissProt Accessions	Q9ES64, Q91XD1, Q9CVG7, Q9ES65	Gene names	Ush1c
Domain Architecture
Description	Harmonin (Usher syndrome type-1C protein homolog) (PDZ domain- containing protein).

FSTL3_MOUSE
NC score	0.050240 (rank : 69)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	30	Target Neighborhood Hits	152	Shared Neighborhood Hits	5
SwissProt Accessions	Q9EQC7	Gene names	Fstl3, Flrg
Domain Architecture
Description	Follistatin-related protein 3 precursor (Follistatin-like 3) (Follistatin-related gene protein).

LAP4_HUMAN
NC score	0.049461 (rank : 70)	θ value	0.163984 (rank : 11)
Query Neighborhood Hits	30	Target Neighborhood Hits	608	Shared Neighborhood Hits	23
SwissProt Accessions	Q14160, Q6P496, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1	Gene names	SCRIB, CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog) (hScrib).

GRIP2_HUMAN
NC score	0.048989 (rank : 71)	θ value	3.0926 (rank : 21)
Query Neighborhood Hits	30	Target Neighborhood Hits	256	Shared Neighborhood Hits	21
SwissProt Accessions	Q9C0E4, Q8TEH9, Q9H7H3	Gene names	GRIP2, KIAA1719
Domain Architecture
Description	Glutamate receptor-interacting protein 2 (GRIP2 protein).

PDLI3_MOUSE
NC score	0.046466 (rank : 72)	θ value	1.06291 (rank : 17)
Query Neighborhood Hits	30	Target Neighborhood Hits	197	Shared Neighborhood Hits	14
SwissProt Accessions	O70209	Gene names	Pdlim3
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha- actinin-2-associated LIM protein).

LAP4_MOUSE
NC score	0.044800 (rank : 73)	θ value	0.125558 (rank : 10)
Query Neighborhood Hits	30	Target Neighborhood Hits	590	Shared Neighborhood Hits	23
SwissProt Accessions	Q80U72, Q6P5H7, Q7TPH8, Q80VB1, Q8CI48, Q8VII1, Q922S3	Gene names	Scrib, Kiaa0147, Lap4, Scrib1
Domain Architecture	No domain graphic available
Description	Protein LAP4 (Protein scribble homolog).

PDLI2_HUMAN
NC score	0.042595 (rank : 74)	θ value	3.0926 (rank : 22)
Query Neighborhood Hits	30	Target Neighborhood Hits	245	Shared Neighborhood Hits	16
SwissProt Accessions	Q96JY6, Q7Z584, Q86WM8, Q8WZ29, Q9H4L9, Q9H7I2	Gene names	PDLIM2
Domain Architecture	No domain graphic available
Description	PDZ and LIM domain protein 2 (PDZ-LIM protein mystique) (PDZ-LIM protein).

DLG5_HUMAN
NC score	0.031010 (rank : 75)	θ value	0.813845 (rank : 16)
Query Neighborhood Hits	30	Target Neighborhood Hits	1088	Shared Neighborhood Hits	18
SwissProt Accessions	Q8TDM6, Q5T1H7, Q5T1H8, Q6DKG3, Q86WC0, Q8TDM7, Q9UE73, Q9Y4E3	Gene names	DLG5, KIAA0583, PDLG
Domain Architecture
Description	Discs large homolog 5 (Placenta and prostate DLG) (Discs large protein P-dlg).

RGS12_HUMAN
NC score	0.030249 (rank : 76)	θ value	1.38821 (rank : 19)
Query Neighborhood Hits	30	Target Neighborhood Hits	333	Shared Neighborhood Hits	17
SwissProt Accessions	O14924, O14922, O14923, O43510, O75338	Gene names	RGS12
Domain Architecture
Description	Regulator of G-protein signaling 12 (RGS12).

BHLH4_HUMAN
NC score	0.025331 (rank : 77)	θ value	0.47712 (rank : 14)
Query Neighborhood Hits	30	Target Neighborhood Hits	70	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NDY6	Gene names	BHLHB4
Domain Architecture	No domain graphic available
Description	Class B basic helix-loop-helix protein 4 (bHLHB4).

TROAP_HUMAN
NC score	0.021755 (rank : 78)	θ value	3.0926 (rank : 23)
Query Neighborhood Hits	30	Target Neighborhood Hits	258	Shared Neighborhood Hits	3
SwissProt Accessions	Q12815	Gene names	TROAP
Domain Architecture	No domain graphic available
Description	Trophinin-associated protein (Tastin) (Trophinin-assisting protein).

SHAN1_HUMAN
NC score	0.016806 (rank : 79)	θ value	5.27518 (rank : 26)
Query Neighborhood Hits	30	Target Neighborhood Hits	1041	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

CREG2_HUMAN
NC score	0.015607 (rank : 80)	θ value	8.99809 (rank : 27)
Query Neighborhood Hits	30	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IUH2, Q86X03, Q8N540, Q8N9E3	Gene names	CREG2
Domain Architecture	No domain graphic available
Description	Protein CREG2 precursor.

DACT1_HUMAN
NC score	0.009451 (rank : 81)	θ value	8.99809 (rank : 28)
Query Neighborhood Hits	30	Target Neighborhood Hits	228	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NYF0, Q86TY0	Gene names	DACT1, DPR1, HNG3
Domain Architecture	No domain graphic available
Description	Dapper homolog 1 (hDPR1) (Heptacellular carcinoma novel gene 3 protein).

CO5_MOUSE
NC score	0.008330 (rank : 82)	θ value	5.27518 (rank : 24)
Query Neighborhood Hits	30	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	P06684	Gene names	C5, Hc
Domain Architecture
Description	Complement C5 precursor (Hemolytic complement) [Contains: Complement C5 beta chain; Complement C5 alpha chain; C5a anaphylatoxin; Complement C5 alpha' chain].

AN30A_HUMAN
NC score	0.006183 (rank : 83)	θ value	1.38821 (rank : 18)
Query Neighborhood Hits	30	Target Neighborhood Hits	1119	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).

SEM3B_HUMAN
NC score	0.002634 (rank : 84)	θ value	8.99809 (rank : 30)
Query Neighborhood Hits	30	Target Neighborhood Hits	76	Shared Neighborhood Hits	2
SwissProt Accessions	Q13214, Q8TB71, Q8TDV7, Q93018, Q96GX0	Gene names	SEMA3B, SEMA5
Domain Architecture
Description	Semaphorin-3B precursor (Semaphorin V) (Sema V) (Sema A(V)).