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Network neighborhood for query Sequence : BIRC5_HUMAN

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BIRC5_HUMAN
SwissProt Accessions	O15392, Q2I3N8, Q4VGX0, Q53F61, Q5MGC6, Q6FHL2, Q75SP2, Q9P2W8	Gene names	BIRC5, API4, IAP4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

BIRC5_HUMAN
θ value	1.66191e-70 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	O15392, Q2I3N8, Q4VGX0, Q53F61, Q5MGC6, Q6FHL2, Q75SP2, Q9P2W8	Gene names	BIRC5, API4, IAP4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4).

BIRC5_MOUSE
θ value	9.11921e-69 (rank : 2)	NC score	0.997902 (rank : 2)
Query Neighborhood Hits	20	Target Neighborhood Hits	19	Shared Neighborhood Hits	17
SwissProt Accessions	O70201, Q923F7, Q9WU53, Q9WU54	Gene names	Birc5, Api4, Iap4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4) (TIAP).

BIRC6_HUMAN
θ value	8.67504e-11 (rank : 3)	NC score	0.473040 (rank : 17)
Query Neighborhood Hits	20	Target Neighborhood Hits	161	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NR09, Q9ULD1	Gene names	BIRC6, KIAA1289
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 6 (Ubiquitin-conjugating BIR-domain enzyme apollon).

BIRC1_HUMAN
θ value	1.63604e-09 (rank : 4)	NC score	0.629823 (rank : 5)
Query Neighborhood Hits	20	Target Neighborhood Hits	61	Shared Neighborhood Hits	17
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

BIR1F_MOUSE
θ value	1.38499e-08 (rank : 5)	NC score	0.619030 (rank : 7)
Query Neighborhood Hits	20	Target Neighborhood Hits	88	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

BIR1A_MOUSE
θ value	2.36244e-08 (rank : 6)	NC score	0.617640 (rank : 10)
Query Neighborhood Hits	20	Target Neighborhood Hits	94	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

BIR1E_MOUSE
θ value	2.36244e-08 (rank : 7)	NC score	0.618864 (rank : 8)
Query Neighborhood Hits	20	Target Neighborhood Hits	93	Shared Neighborhood Hits	17
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

BIR1G_MOUSE
θ value	2.36244e-08 (rank : 8)	NC score	0.618283 (rank : 9)
Query Neighborhood Hits	20	Target Neighborhood Hits	92	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

BIR1B_MOUSE
θ value	3.08544e-08 (rank : 9)	NC score	0.621679 (rank : 6)
Query Neighborhood Hits	20	Target Neighborhood Hits	93	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

BIRC7_HUMAN
θ value	1.53129e-07 (rank : 10)	NC score	0.596626 (rank : 16)
Query Neighborhood Hits	20	Target Neighborhood Hits	185	Shared Neighborhood Hits	18
SwissProt Accessions	Q96CA5, Q9BQV0, Q9H2A8, Q9HAP7	Gene names	BIRC7, KIAP, LIVIN, MLIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 7 (Kidney inhibitor of apoptosis protein) (KIAP) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (Livin).

BIRC4_MOUSE
θ value	3.41135e-07 (rank : 11)	NC score	0.646726 (rank : 3)
Query Neighborhood Hits	20	Target Neighborhood Hits	89	Shared Neighborhood Hits	18
SwissProt Accessions	Q60989, O08865	Gene names	Birc4, Aipa, Api3, Miha, Xiap
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3).

BIRC2_HUMAN
θ value	1.29631e-06 (rank : 12)	NC score	0.605749 (rank : 12)
Query Neighborhood Hits	20	Target Neighborhood Hits	142	Shared Neighborhood Hits	18
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

BIRC8_HUMAN
θ value	1.69304e-06 (rank : 13)	NC score	0.610497 (rank : 11)
Query Neighborhood Hits	20	Target Neighborhood Hits	121	Shared Neighborhood Hits	17
SwissProt Accessions	Q96P09, Q96RW5	Gene names	BIRC8, ILP2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis- like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis).

BIRC2_MOUSE
θ value	2.88788e-06 (rank : 14)	NC score	0.603434 (rank : 13)
Query Neighborhood Hits	20	Target Neighborhood Hits	137	Shared Neighborhood Hits	18
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

BIRC4_HUMAN
θ value	2.88788e-06 (rank : 15)	NC score	0.640522 (rank : 4)
Query Neighborhood Hits	20	Target Neighborhood Hits	89	Shared Neighborhood Hits	18
SwissProt Accessions	P98170, Q9NQ14	Gene names	BIRC4, API3, IAP3, XIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP).

BIRC3_MOUSE
θ value	6.43352e-06 (rank : 16)	NC score	0.602014 (rank : 15)
Query Neighborhood Hits	20	Target Neighborhood Hits	113	Shared Neighborhood Hits	18
SwissProt Accessions	O08863	Gene names	Birc3, Birc2, Iap1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (MIAP1) (MIAP-1).

BIRC3_HUMAN
θ value	1.43324e-05 (rank : 17)	NC score	0.602794 (rank : 14)
Query Neighborhood Hits	20	Target Neighborhood Hits	133	Shared Neighborhood Hits	18
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).

MDM2_MOUSE
θ value	4.03905 (rank : 18)	NC score	0.053173 (rank : 41)
Query Neighborhood Hits	20	Target Neighborhood Hits	77	Shared Neighborhood Hits	9
SwissProt Accessions	P23804, Q61040, Q64330	Gene names	Mdm2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein).

MYO5A_MOUSE
θ value	5.27518 (rank : 19)	NC score	0.005629 (rank : 47)
Query Neighborhood Hits	20	Target Neighborhood Hits	1117	Shared Neighborhood Hits	3
SwissProt Accessions	Q99104	Gene names	Myo5a, Dilute
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle).

MYO5A_HUMAN
θ value	8.99809 (rank : 20)	NC score	0.005083 (rank : 48)
Query Neighborhood Hits	20	Target Neighborhood Hits	1092	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y4I1, O60653, Q07902, Q16249, Q9UE30, Q9UE31	Gene names	MYO5A, MYH12
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myoxin).

CAR12_HUMAN
θ value	θ > 10 (rank : 21)	NC score	0.317855 (rank : 18)
Query Neighborhood Hits	20	Target Neighborhood Hits	132	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NPP4, Q96J81, Q96J82, Q96J83	Gene names	CARD12, CLAN, CLAN1
Domain Architecture
Description	Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein).

CAR15_HUMAN
θ value	θ > 10 (rank : 22)	NC score	0.060788 (rank : 35)
Query Neighborhood Hits	20	Target Neighborhood Hits	77	Shared Neighborhood Hits	7
SwissProt Accessions	Q9HC29, Q96RH5, Q96RH6, Q96RH8	Gene names	CARD15, IBD1, NOD2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1).

CAR15_MOUSE
θ value	θ > 10 (rank : 23)	NC score	0.073402 (rank : 30)
Query Neighborhood Hits	20	Target Neighborhood Hits	93	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K3Z0	Gene names	Card15, Nod2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2).

CGRF1_HUMAN
θ value	θ > 10 (rank : 24)	NC score	0.088795 (rank : 27)
Query Neighborhood Hits	20	Target Neighborhood Hits	51	Shared Neighborhood Hits	8
SwissProt Accessions	Q99675, Q96BX2	Gene names	CGRRF1, CGR19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

CGRF1_MOUSE
θ value	θ > 10 (rank : 25)	NC score	0.084353 (rank : 28)
Query Neighborhood Hits	20	Target Neighborhood Hits	47	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BMJ7, Q3U3F1, Q8CI24	Gene names	Cgrrf1, Cgr19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

LRC31_HUMAN
θ value	θ > 10 (rank : 26)	NC score	0.110345 (rank : 24)
Query Neighborhood Hits	20	Target Neighborhood Hits	139	Shared Neighborhood Hits	6
SwissProt Accessions	Q6UY01, Q8N848, Q9H5N5	Gene names	LRRC31
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 31.

LRSM1_HUMAN
θ value	θ > 10 (rank : 27)	NC score	0.052268 (rank : 45)
Query Neighborhood Hits	20	Target Neighborhood Hits	1078	Shared Neighborhood Hits	11
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

LRSM1_MOUSE
θ value	θ > 10 (rank : 28)	NC score	0.060004 (rank : 36)
Query Neighborhood Hits	20	Target Neighborhood Hits	874	Shared Neighborhood Hits	11
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

MDM2_HUMAN
θ value	θ > 10 (rank : 29)	NC score	0.050011 (rank : 46)
Query Neighborhood Hits	20	Target Neighborhood Hits	92	Shared Neighborhood Hits	8
SwissProt Accessions	Q00987, Q13226, Q13297, Q13298, Q13299, Q13300, Q13301, Q53XW0, Q71TW9, Q9UGI3, Q9UMT8	Gene names	MDM2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2).

MDM4_HUMAN
θ value	θ > 10 (rank : 30)	NC score	0.057583 (rank : 38)
Query Neighborhood Hits	20	Target Neighborhood Hits	37	Shared Neighborhood Hits	8
SwissProt Accessions	O15151, Q6GS18, Q8IV83	Gene names	MDM4, MDMX
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

MGRN1_HUMAN
θ value	θ > 10 (rank : 31)	NC score	0.055690 (rank : 40)
Query Neighborhood Hits	20	Target Neighborhood Hits	192	Shared Neighborhood Hits	9
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

MGRN1_MOUSE
θ value	θ > 10 (rank : 32)	NC score	0.058031 (rank : 37)
Query Neighborhood Hits	20	Target Neighborhood Hits	149	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D074, Q3U5V9, Q3UDA1, Q6ZQ97, Q8BZM9	Gene names	Mgrn1, Kiaa0544
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1).

MYLIP_HUMAN
θ value	θ > 10 (rank : 33)	NC score	0.093837 (rank : 26)
Query Neighborhood Hits	20	Target Neighborhood Hits	162	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

MYLIP_MOUSE
θ value	θ > 10 (rank : 34)	NC score	0.077985 (rank : 29)
Query Neighborhood Hits	20	Target Neighborhood Hits	139	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

NAL10_HUMAN
θ value	θ > 10 (rank : 35)	NC score	0.052991 (rank : 42)
Query Neighborhood Hits	20	Target Neighborhood Hits	55	Shared Neighborhood Hits	6
SwissProt Accessions	Q86W26, Q6JGT0	Gene names	NALP10, NOD8, PYNOD
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10 (Nucleotide-binding oligomerization domain protein 8).

NAL10_MOUSE
θ value	θ > 10 (rank : 36)	NC score	0.066454 (rank : 33)
Query Neighborhood Hits	20	Target Neighborhood Hits	46	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CCN1	Gene names	Nalp10, Pynod
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10.

NAL13_HUMAN
θ value	θ > 10 (rank : 37)	NC score	0.052844 (rank : 43)
Query Neighborhood Hits	20	Target Neighborhood Hits	93	Shared Neighborhood Hits	6
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

NALP1_HUMAN
θ value	θ > 10 (rank : 38)	NC score	0.063879 (rank : 34)
Query Neighborhood Hits	20	Target Neighborhood Hits	138	Shared Neighborhood Hits	6
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

NALP2_HUMAN
θ value	θ > 10 (rank : 39)	NC score	0.057181 (rank : 39)
Query Neighborhood Hits	20	Target Neighborhood Hits	65	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NX02, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3	Gene names	NALP2, NBS1, PAN1, PYPAF2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 2 (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) (Nucleotide-binding site protein 1).

NALP7_HUMAN
θ value	θ > 10 (rank : 40)	NC score	0.052462 (rank : 44)
Query Neighborhood Hits	20	Target Neighborhood Hits	65	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

NEUL1_HUMAN
θ value	θ > 10 (rank : 41)	NC score	0.070755 (rank : 32)
Query Neighborhood Hits	20	Target Neighborhood Hits	114	Shared Neighborhood Hits	9
SwissProt Accessions	O76050, Q5TDR2, Q5TDR3, Q8TAN0, Q9H463	Gene names	NEURL, NEURL1, RNF67
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (h-neuralized 1) (h-neu) (RING finger protein 67).

NEURL_MOUSE
θ value	θ > 10 (rank : 42)	NC score	0.073276 (rank : 31)
Query Neighborhood Hits	20	Target Neighborhood Hits	106	Shared Neighborhood Hits	9
SwissProt Accessions	Q923S6, Q91ZT6, Q9CWF1, Q9QWF1	Gene names	Neurl, Neurl1
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (m-neuralized 1) (m-neu1).

RFFL_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.128608 (rank : 23)
Query Neighborhood Hits	20	Target Neighborhood Hits	175	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

RFFL_MOUSE
θ value	θ > 10 (rank : 44)	NC score	0.130753 (rank : 20)
Query Neighborhood Hits	20	Target Neighborhood Hits	145	Shared Neighborhood Hits	9
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RKHD1_HUMAN
θ value	θ > 10 (rank : 45)	NC score	0.095937 (rank : 25)
Query Neighborhood Hits	20	Target Neighborhood Hits	163	Shared Neighborhood Hits	8
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

RNF26_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.144504 (rank : 19)
Query Neighborhood Hits	20	Target Neighborhood Hits	95	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BY78	Gene names	RNF26
Domain Architecture	No domain graphic available
Description	RING finger protein 26.

RNF34_HUMAN
θ value	θ > 10 (rank : 47)	NC score	0.128731 (rank : 22)
Query Neighborhood Hits	20	Target Neighborhood Hits	153	Shared Neighborhood Hits	9
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

RNF34_MOUSE
θ value	θ > 10 (rank : 48)	NC score	0.129291 (rank : 21)
Query Neighborhood Hits	20	Target Neighborhood Hits	160	Shared Neighborhood Hits	9
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

Hits sorted by NC score

BIRC5_HUMAN
NC score	0.999962 (rank : 1)	θ value	1.66191e-70 (rank : 1)
Query Neighborhood Hits	20	Target Neighborhood Hits	20	Shared Neighborhood Hits	20
SwissProt Accessions	O15392, Q2I3N8, Q4VGX0, Q53F61, Q5MGC6, Q6FHL2, Q75SP2, Q9P2W8	Gene names	BIRC5, API4, IAP4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4).

BIRC5_MOUSE
NC score	0.997902 (rank : 2)	θ value	9.11921e-69 (rank : 2)
Query Neighborhood Hits	20	Target Neighborhood Hits	19	Shared Neighborhood Hits	17
SwissProt Accessions	O70201, Q923F7, Q9WU53, Q9WU54	Gene names	Birc5, Api4, Iap4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4) (TIAP).

BIRC4_MOUSE
NC score	0.646726 (rank : 3)	θ value	3.41135e-07 (rank : 11)
Query Neighborhood Hits	20	Target Neighborhood Hits	89	Shared Neighborhood Hits	18
SwissProt Accessions	Q60989, O08865	Gene names	Birc4, Aipa, Api3, Miha, Xiap
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3).

BIRC4_HUMAN
NC score	0.640522 (rank : 4)	θ value	2.88788e-06 (rank : 15)
Query Neighborhood Hits	20	Target Neighborhood Hits	89	Shared Neighborhood Hits	18
SwissProt Accessions	P98170, Q9NQ14	Gene names	BIRC4, API3, IAP3, XIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP).

BIRC1_HUMAN
NC score	0.629823 (rank : 5)	θ value	1.63604e-09 (rank : 4)
Query Neighborhood Hits	20	Target Neighborhood Hits	61	Shared Neighborhood Hits	17
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

BIR1B_MOUSE
NC score	0.621679 (rank : 6)	θ value	3.08544e-08 (rank : 9)
Query Neighborhood Hits	20	Target Neighborhood Hits	93	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

BIR1F_MOUSE
NC score	0.619030 (rank : 7)	θ value	1.38499e-08 (rank : 5)
Query Neighborhood Hits	20	Target Neighborhood Hits	88	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

BIR1E_MOUSE
NC score	0.618864 (rank : 8)	θ value	2.36244e-08 (rank : 7)
Query Neighborhood Hits	20	Target Neighborhood Hits	93	Shared Neighborhood Hits	17
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

BIR1G_MOUSE
NC score	0.618283 (rank : 9)	θ value	2.36244e-08 (rank : 8)
Query Neighborhood Hits	20	Target Neighborhood Hits	92	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

BIR1A_MOUSE
NC score	0.617640 (rank : 10)	θ value	2.36244e-08 (rank : 6)
Query Neighborhood Hits	20	Target Neighborhood Hits	94	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

BIRC8_HUMAN
NC score	0.610497 (rank : 11)	θ value	1.69304e-06 (rank : 13)
Query Neighborhood Hits	20	Target Neighborhood Hits	121	Shared Neighborhood Hits	17
SwissProt Accessions	Q96P09, Q96RW5	Gene names	BIRC8, ILP2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis- like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis).

BIRC2_HUMAN
NC score	0.605749 (rank : 12)	θ value	1.29631e-06 (rank : 12)
Query Neighborhood Hits	20	Target Neighborhood Hits	142	Shared Neighborhood Hits	18
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

BIRC2_MOUSE
NC score	0.603434 (rank : 13)	θ value	2.88788e-06 (rank : 14)
Query Neighborhood Hits	20	Target Neighborhood Hits	137	Shared Neighborhood Hits	18
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

BIRC3_HUMAN
NC score	0.602794 (rank : 14)	θ value	1.43324e-05 (rank : 17)
Query Neighborhood Hits	20	Target Neighborhood Hits	133	Shared Neighborhood Hits	18
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).

BIRC3_MOUSE
NC score	0.602014 (rank : 15)	θ value	6.43352e-06 (rank : 16)
Query Neighborhood Hits	20	Target Neighborhood Hits	113	Shared Neighborhood Hits	18
SwissProt Accessions	O08863	Gene names	Birc3, Birc2, Iap1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (MIAP1) (MIAP-1).

BIRC7_HUMAN
NC score	0.596626 (rank : 16)	θ value	1.53129e-07 (rank : 10)
Query Neighborhood Hits	20	Target Neighborhood Hits	185	Shared Neighborhood Hits	18
SwissProt Accessions	Q96CA5, Q9BQV0, Q9H2A8, Q9HAP7	Gene names	BIRC7, KIAP, LIVIN, MLIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 7 (Kidney inhibitor of apoptosis protein) (KIAP) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (Livin).

BIRC6_HUMAN
NC score	0.473040 (rank : 17)	θ value	8.67504e-11 (rank : 3)
Query Neighborhood Hits	20	Target Neighborhood Hits	161	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NR09, Q9ULD1	Gene names	BIRC6, KIAA1289
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 6 (Ubiquitin-conjugating BIR-domain enzyme apollon).

CAR12_HUMAN
NC score	0.317855 (rank : 18)	θ value	θ > 10 (rank : 21)
Query Neighborhood Hits	20	Target Neighborhood Hits	132	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NPP4, Q96J81, Q96J82, Q96J83	Gene names	CARD12, CLAN, CLAN1
Domain Architecture
Description	Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein).

RNF26_HUMAN
NC score	0.144504 (rank : 19)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	20	Target Neighborhood Hits	95	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BY78	Gene names	RNF26
Domain Architecture	No domain graphic available
Description	RING finger protein 26.

RFFL_MOUSE
NC score	0.130753 (rank : 20)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	20	Target Neighborhood Hits	145	Shared Neighborhood Hits	9
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RNF34_MOUSE
NC score	0.129291 (rank : 21)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	20	Target Neighborhood Hits	160	Shared Neighborhood Hits	9
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

RNF34_HUMAN
NC score	0.128731 (rank : 22)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	20	Target Neighborhood Hits	153	Shared Neighborhood Hits	9
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

RFFL_HUMAN
NC score	0.128608 (rank : 23)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	20	Target Neighborhood Hits	175	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

LRC31_HUMAN
NC score	0.110345 (rank : 24)	θ value	θ > 10 (rank : 26)
Query Neighborhood Hits	20	Target Neighborhood Hits	139	Shared Neighborhood Hits	6
SwissProt Accessions	Q6UY01, Q8N848, Q9H5N5	Gene names	LRRC31
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 31.

RKHD1_HUMAN
NC score	0.095937 (rank : 25)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	20	Target Neighborhood Hits	163	Shared Neighborhood Hits	8
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

MYLIP_HUMAN
NC score	0.093837 (rank : 26)	θ value	θ > 10 (rank : 33)
Query Neighborhood Hits	20	Target Neighborhood Hits	162	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

CGRF1_HUMAN
NC score	0.088795 (rank : 27)	θ value	θ > 10 (rank : 24)
Query Neighborhood Hits	20	Target Neighborhood Hits	51	Shared Neighborhood Hits	8
SwissProt Accessions	Q99675, Q96BX2	Gene names	CGRRF1, CGR19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

CGRF1_MOUSE
NC score	0.084353 (rank : 28)	θ value	θ > 10 (rank : 25)
Query Neighborhood Hits	20	Target Neighborhood Hits	47	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BMJ7, Q3U3F1, Q8CI24	Gene names	Cgrrf1, Cgr19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

MYLIP_MOUSE
NC score	0.077985 (rank : 29)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	20	Target Neighborhood Hits	139	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

CAR15_MOUSE
NC score	0.073402 (rank : 30)	θ value	θ > 10 (rank : 23)
Query Neighborhood Hits	20	Target Neighborhood Hits	93	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K3Z0	Gene names	Card15, Nod2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2).

NEURL_MOUSE
NC score	0.073276 (rank : 31)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	20	Target Neighborhood Hits	106	Shared Neighborhood Hits	9
SwissProt Accessions	Q923S6, Q91ZT6, Q9CWF1, Q9QWF1	Gene names	Neurl, Neurl1
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (m-neuralized 1) (m-neu1).

NEUL1_HUMAN
NC score	0.070755 (rank : 32)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	20	Target Neighborhood Hits	114	Shared Neighborhood Hits	9
SwissProt Accessions	O76050, Q5TDR2, Q5TDR3, Q8TAN0, Q9H463	Gene names	NEURL, NEURL1, RNF67
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (h-neuralized 1) (h-neu) (RING finger protein 67).

NAL10_MOUSE
NC score	0.066454 (rank : 33)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	20	Target Neighborhood Hits	46	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CCN1	Gene names	Nalp10, Pynod
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10.

NALP1_HUMAN
NC score	0.063879 (rank : 34)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	20	Target Neighborhood Hits	138	Shared Neighborhood Hits	6
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

CAR15_HUMAN
NC score	0.060788 (rank : 35)	θ value	θ > 10 (rank : 22)
Query Neighborhood Hits	20	Target Neighborhood Hits	77	Shared Neighborhood Hits	7
SwissProt Accessions	Q9HC29, Q96RH5, Q96RH6, Q96RH8	Gene names	CARD15, IBD1, NOD2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1).

LRSM1_MOUSE
NC score	0.060004 (rank : 36)	θ value	θ > 10 (rank : 28)
Query Neighborhood Hits	20	Target Neighborhood Hits	874	Shared Neighborhood Hits	11
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

MGRN1_MOUSE
NC score	0.058031 (rank : 37)	θ value	θ > 10 (rank : 32)
Query Neighborhood Hits	20	Target Neighborhood Hits	149	Shared Neighborhood Hits	9
SwissProt Accessions	Q9D074, Q3U5V9, Q3UDA1, Q6ZQ97, Q8BZM9	Gene names	Mgrn1, Kiaa0544
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1).

MDM4_HUMAN
NC score	0.057583 (rank : 38)	θ value	θ > 10 (rank : 30)
Query Neighborhood Hits	20	Target Neighborhood Hits	37	Shared Neighborhood Hits	8
SwissProt Accessions	O15151, Q6GS18, Q8IV83	Gene names	MDM4, MDMX
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

NALP2_HUMAN
NC score	0.057181 (rank : 39)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	20	Target Neighborhood Hits	65	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NX02, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3	Gene names	NALP2, NBS1, PAN1, PYPAF2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 2 (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) (Nucleotide-binding site protein 1).

MGRN1_HUMAN
NC score	0.055690 (rank : 40)	θ value	θ > 10 (rank : 31)
Query Neighborhood Hits	20	Target Neighborhood Hits	192	Shared Neighborhood Hits	9
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

MDM2_MOUSE
NC score	0.053173 (rank : 41)	θ value	4.03905 (rank : 18)
Query Neighborhood Hits	20	Target Neighborhood Hits	77	Shared Neighborhood Hits	9
SwissProt Accessions	P23804, Q61040, Q64330	Gene names	Mdm2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein).

NAL10_HUMAN
NC score	0.052991 (rank : 42)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	20	Target Neighborhood Hits	55	Shared Neighborhood Hits	6
SwissProt Accessions	Q86W26, Q6JGT0	Gene names	NALP10, NOD8, PYNOD
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10 (Nucleotide-binding oligomerization domain protein 8).

NAL13_HUMAN
NC score	0.052844 (rank : 43)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	20	Target Neighborhood Hits	93	Shared Neighborhood Hits	6
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

NALP7_HUMAN
NC score	0.052462 (rank : 44)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	20	Target Neighborhood Hits	65	Shared Neighborhood Hits	6
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

LRSM1_HUMAN
NC score	0.052268 (rank : 45)	θ value	θ > 10 (rank : 27)
Query Neighborhood Hits	20	Target Neighborhood Hits	1078	Shared Neighborhood Hits	11
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

MDM2_HUMAN
NC score	0.050011 (rank : 46)	θ value	θ > 10 (rank : 29)
Query Neighborhood Hits	20	Target Neighborhood Hits	92	Shared Neighborhood Hits	8
SwissProt Accessions	Q00987, Q13226, Q13297, Q13298, Q13299, Q13300, Q13301, Q53XW0, Q71TW9, Q9UGI3, Q9UMT8	Gene names	MDM2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2).

MYO5A_MOUSE
NC score	0.005629 (rank : 47)	θ value	5.27518 (rank : 19)
Query Neighborhood Hits	20	Target Neighborhood Hits	1117	Shared Neighborhood Hits	3
SwissProt Accessions	Q99104	Gene names	Myo5a, Dilute
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle).

MYO5A_HUMAN
NC score	0.005083 (rank : 48)	θ value	8.99809 (rank : 20)
Query Neighborhood Hits	20	Target Neighborhood Hits	1092	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y4I1, O60653, Q07902, Q16249, Q9UE30, Q9UE31	Gene names	MYO5A, MYH12
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myoxin).