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Network neighborhood for query Sequence : BIRC2_HUMAN

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BIRC2_HUMAN
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

BIRC2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	142	Target Neighborhood Hits	142	Shared Neighborhood Hits	142
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

BIRC2_MOUSE
θ value	0 (rank : 2)	NC score	0.996181 (rank : 2)
Query Neighborhood Hits	142	Target Neighborhood Hits	137	Shared Neighborhood Hits	121
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

BIRC3_HUMAN
θ value	0 (rank : 3)	NC score	0.992665 (rank : 3)
Query Neighborhood Hits	142	Target Neighborhood Hits	133	Shared Neighborhood Hits	116
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).

BIRC3_MOUSE
θ value	0 (rank : 4)	NC score	0.988354 (rank : 4)
Query Neighborhood Hits	142	Target Neighborhood Hits	113	Shared Neighborhood Hits	99
SwissProt Accessions	O08863	Gene names	Birc3, Birc2, Iap1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (MIAP1) (MIAP-1).

BIRC4_HUMAN
θ value	1.00591e-75 (rank : 5)	NC score	0.927059 (rank : 5)
Query Neighborhood Hits	142	Target Neighborhood Hits	89	Shared Neighborhood Hits	78
SwissProt Accessions	P98170, Q9NQ14	Gene names	BIRC4, API3, IAP3, XIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP).

BIRC4_MOUSE
θ value	1.11217e-74 (rank : 6)	NC score	0.926047 (rank : 6)
Query Neighborhood Hits	142	Target Neighborhood Hits	89	Shared Neighborhood Hits	78
SwissProt Accessions	Q60989, O08865	Gene names	Birc4, Aipa, Api3, Miha, Xiap
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3).

BIR1E_MOUSE
θ value	7.27602e-42 (rank : 7)	NC score	0.711231 (rank : 10)
Query Neighborhood Hits	142	Target Neighborhood Hits	93	Shared Neighborhood Hits	19
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

BIR1F_MOUSE
θ value	9.50281e-42 (rank : 8)	NC score	0.710564 (rank : 12)
Query Neighborhood Hits	142	Target Neighborhood Hits	88	Shared Neighborhood Hits	20
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

BIR1G_MOUSE
θ value	1.62093e-41 (rank : 9)	NC score	0.710519 (rank : 13)
Query Neighborhood Hits	142	Target Neighborhood Hits	92	Shared Neighborhood Hits	20
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

BIRC1_HUMAN
θ value	5.76516e-39 (rank : 10)	NC score	0.713640 (rank : 9)
Query Neighborhood Hits	142	Target Neighborhood Hits	61	Shared Neighborhood Hits	20
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

BIR1B_MOUSE
θ value	9.83387e-39 (rank : 11)	NC score	0.710989 (rank : 11)
Query Neighborhood Hits	142	Target Neighborhood Hits	93	Shared Neighborhood Hits	20
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

BIR1A_MOUSE
θ value	4.88048e-38 (rank : 12)	NC score	0.704498 (rank : 14)
Query Neighborhood Hits	142	Target Neighborhood Hits	94	Shared Neighborhood Hits	19
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

BIRC8_HUMAN
θ value	1.12775e-26 (rank : 13)	NC score	0.870041 (rank : 7)
Query Neighborhood Hits	142	Target Neighborhood Hits	121	Shared Neighborhood Hits	95
SwissProt Accessions	Q96P09, Q96RW5	Gene names	BIRC8, ILP2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis- like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis).

BIRC7_HUMAN
θ value	1.37858e-24 (rank : 14)	NC score	0.844941 (rank : 8)
Query Neighborhood Hits	142	Target Neighborhood Hits	185	Shared Neighborhood Hits	113
SwissProt Accessions	Q96CA5, Q9BQV0, Q9H2A8, Q9HAP7	Gene names	BIRC7, KIAP, LIVIN, MLIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 7 (Kidney inhibitor of apoptosis protein) (KIAP) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (Livin).

MYLIP_HUMAN
θ value	5.08577e-11 (rank : 15)	NC score	0.295955 (rank : 29)
Query Neighborhood Hits	142	Target Neighborhood Hits	162	Shared Neighborhood Hits	75
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

BIRC6_HUMAN
θ value	9.59137e-10 (rank : 16)	NC score	0.380637 (rank : 23)
Query Neighborhood Hits	142	Target Neighborhood Hits	161	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NR09, Q9ULD1	Gene names	BIRC6, KIAA1289
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 6 (Ubiquitin-conjugating BIR-domain enzyme apollon).

RFFL_HUMAN
θ value	4.76016e-09 (rank : 17)	NC score	0.462711 (rank : 20)
Query Neighborhood Hits	142	Target Neighborhood Hits	175	Shared Neighborhood Hits	74
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

RFFL_MOUSE
θ value	4.76016e-09 (rank : 18)	NC score	0.469263 (rank : 17)
Query Neighborhood Hits	142	Target Neighborhood Hits	145	Shared Neighborhood Hits	74
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RNF34_HUMAN
θ value	5.26297e-08 (rank : 19)	NC score	0.464235 (rank : 19)
Query Neighborhood Hits	142	Target Neighborhood Hits	153	Shared Neighborhood Hits	81
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

RNF34_MOUSE
θ value	5.26297e-08 (rank : 20)	NC score	0.465226 (rank : 18)
Query Neighborhood Hits	142	Target Neighborhood Hits	160	Shared Neighborhood Hits	82
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

MIB1_MOUSE
θ value	8.97725e-08 (rank : 21)	NC score	0.175636 (rank : 45)
Query Neighborhood Hits	142	Target Neighborhood Hits	471	Shared Neighborhood Hits	89
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

LRSM1_MOUSE
θ value	1.17247e-07 (rank : 22)	NC score	0.211584 (rank : 33)
Query Neighborhood Hits	142	Target Neighborhood Hits	874	Shared Neighborhood Hits	74
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

MIB1_HUMAN
θ value	1.17247e-07 (rank : 23)	NC score	0.174140 (rank : 46)
Query Neighborhood Hits	142	Target Neighborhood Hits	470	Shared Neighborhood Hits	89
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

BIRC5_MOUSE
θ value	2.61198e-07 (rank : 24)	NC score	0.625038 (rank : 15)
Query Neighborhood Hits	142	Target Neighborhood Hits	19	Shared Neighborhood Hits	17
SwissProt Accessions	O70201, Q923F7, Q9WU53, Q9WU54	Gene names	Birc5, Api4, Iap4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4) (TIAP).

LRSM1_HUMAN
θ value	2.61198e-07 (rank : 25)	NC score	0.187788 (rank : 39)
Query Neighborhood Hits	142	Target Neighborhood Hits	1078	Shared Neighborhood Hits	77
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

MYLIP_MOUSE
θ value	4.45536e-07 (rank : 26)	NC score	0.252038 (rank : 32)
Query Neighborhood Hits	142	Target Neighborhood Hits	139	Shared Neighborhood Hits	57
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

BIRC5_HUMAN
θ value	1.29631e-06 (rank : 27)	NC score	0.605749 (rank : 16)
Query Neighborhood Hits	142	Target Neighborhood Hits	20	Shared Neighborhood Hits	18
SwissProt Accessions	O15392, Q2I3N8, Q4VGX0, Q53F61, Q5MGC6, Q6FHL2, Q75SP2, Q9P2W8	Gene names	BIRC5, API4, IAP4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4).

MIB2_HUMAN
θ value	4.92598e-06 (rank : 28)	NC score	0.167255 (rank : 47)
Query Neighborhood Hits	142	Target Neighborhood Hits	438	Shared Neighborhood Hits	70
SwissProt Accessions	Q96AX9, Q7Z437, Q8IY62, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1	Gene names	MIB2, SKD, ZZANK1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Zinc finger ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) (Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating protein 002N).

RNF26_HUMAN
θ value	4.92598e-06 (rank : 29)	NC score	0.452178 (rank : 21)
Query Neighborhood Hits	142	Target Neighborhood Hits	95	Shared Neighborhood Hits	60
SwissProt Accessions	Q9BY78	Gene names	RNF26
Domain Architecture	No domain graphic available
Description	RING finger protein 26.

NEURL_MOUSE
θ value	7.1131e-05 (rank : 30)	NC score	0.327355 (rank : 27)
Query Neighborhood Hits	142	Target Neighborhood Hits	106	Shared Neighborhood Hits	68
SwissProt Accessions	Q923S6, Q91ZT6, Q9CWF1, Q9QWF1	Gene names	Neurl, Neurl1
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (m-neuralized 1) (m-neu1).

NEUL1_HUMAN
θ value	9.29e-05 (rank : 31)	NC score	0.322007 (rank : 28)
Query Neighborhood Hits	142	Target Neighborhood Hits	114	Shared Neighborhood Hits	69
SwissProt Accessions	O76050, Q5TDR2, Q5TDR3, Q8TAN0, Q9H463	Gene names	NEURL, NEURL1, RNF67
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (h-neuralized 1) (h-neu) (RING finger protein 67).

CAR12_HUMAN
θ value	0.000158464 (rank : 32)	NC score	0.391022 (rank : 22)
Query Neighborhood Hits	142	Target Neighborhood Hits	132	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NPP4, Q96J81, Q96J82, Q96J83	Gene names	CARD12, CLAN, CLAN1
Domain Architecture
Description	Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein).

MIB2_MOUSE
θ value	0.000158464 (rank : 33)	NC score	0.159548 (rank : 48)
Query Neighborhood Hits	142	Target Neighborhood Hits	409	Shared Neighborhood Hits	68
SwissProt Accessions	Q8R516, Q52QU8, Q6PEF6, Q8C1N7, Q8VIB4	Gene names	Mib2, Skd
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin) (Dystrophin-like protein) (Dyslike).

CGRF1_HUMAN
θ value	0.00035302 (rank : 34)	NC score	0.332593 (rank : 25)
Query Neighborhood Hits	142	Target Neighborhood Hits	51	Shared Neighborhood Hits	38
SwissProt Accessions	Q99675, Q96BX2	Gene names	CGRRF1, CGR19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

CGRF1_MOUSE
θ value	0.000461057 (rank : 35)	NC score	0.330223 (rank : 26)
Query Neighborhood Hits	142	Target Neighborhood Hits	47	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BMJ7, Q3U3F1, Q8CI24	Gene names	Cgrrf1, Cgr19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

RO52_HUMAN
θ value	0.000602161 (rank : 36)	NC score	0.151577 (rank : 53)
Query Neighborhood Hits	142	Target Neighborhood Hits	419	Shared Neighborhood Hits	101
SwissProt Accessions	P19474, Q96RF8	Gene names	TRIM21, RNF81, RO52, SSA1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21) (RING finger protein 81).

TRI26_MOUSE
θ value	0.000602161 (rank : 37)	NC score	0.182299 (rank : 43)
Query Neighborhood Hits	142	Target Neighborhood Hits	339	Shared Neighborhood Hits	103
SwissProt Accessions	Q99PN3, Q8C9E9, Q8JZT7, Q99PN2	Gene names	Trim26, Znf173
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173).

TRI26_HUMAN
θ value	0.00134147 (rank : 38)	NC score	0.178890 (rank : 44)
Query Neighborhood Hits	142	Target Neighborhood Hits	335	Shared Neighborhood Hits	100
SwissProt Accessions	Q12899	Gene names	TRIM26, RNF95, ZNF173
Domain Architecture
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173) (Acid finger protein) (AFP) (RING finger protein 95).

RKHD1_HUMAN
θ value	0.00175202 (rank : 39)	NC score	0.348222 (rank : 24)
Query Neighborhood Hits	142	Target Neighborhood Hits	163	Shared Neighborhood Hits	65
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

CBL_HUMAN
θ value	0.00228821 (rank : 40)	NC score	0.200449 (rank : 35)
Query Neighborhood Hits	142	Target Neighborhood Hits	353	Shared Neighborhood Hits	82
SwissProt Accessions	P22681	Gene names	CBL, CBL2, RNF55
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene) (RING finger protein 55).

CBL_MOUSE
θ value	0.00228821 (rank : 41)	NC score	0.195939 (rank : 38)
Query Neighborhood Hits	142	Target Neighborhood Hits	426	Shared Neighborhood Hits	84
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

CBLB_HUMAN
θ value	0.00509761 (rank : 42)	NC score	0.197962 (rank : 37)
Query Neighborhood Hits	142	Target Neighborhood Hits	261	Shared Neighborhood Hits	84
SwissProt Accessions	Q13191, Q13192, Q13193, Q3LIC0, Q8IVC5	Gene names	CBLB, RNF56
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56).

CBLB_MOUSE
θ value	0.00509761 (rank : 43)	NC score	0.198277 (rank : 36)
Query Neighborhood Hits	142	Target Neighborhood Hits	277	Shared Neighborhood Hits	84
SwissProt Accessions	Q3TTA7	Gene names	Cblb
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b).

MGRN1_HUMAN
θ value	0.00509761 (rank : 44)	NC score	0.257502 (rank : 31)
Query Neighborhood Hits	142	Target Neighborhood Hits	192	Shared Neighborhood Hits	74
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

MGRN1_MOUSE
θ value	0.00509761 (rank : 45)	NC score	0.263755 (rank : 30)
Query Neighborhood Hits	142	Target Neighborhood Hits	149	Shared Neighborhood Hits	74
SwissProt Accessions	Q9D074, Q3U5V9, Q3UDA1, Q6ZQ97, Q8BZM9	Gene names	Mgrn1, Kiaa0544
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1).

MDM4_HUMAN
θ value	0.00869519 (rank : 46)	NC score	0.182622 (rank : 42)
Query Neighborhood Hits	142	Target Neighborhood Hits	37	Shared Neighborhood Hits	24
SwissProt Accessions	O15151, Q6GS18, Q8IV83	Gene names	MDM4, MDMX
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

RO52_MOUSE
θ value	0.00869519 (rank : 47)	NC score	0.144872 (rank : 56)
Query Neighborhood Hits	142	Target Neighborhood Hits	360	Shared Neighborhood Hits	94
SwissProt Accessions	Q62191	Gene names	Trim21, Ro52, Ssa1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21).

TRI17_MOUSE
θ value	0.0113563 (rank : 48)	NC score	0.127981 (rank : 67)
Query Neighborhood Hits	142	Target Neighborhood Hits	620	Shared Neighborhood Hits	87
SwissProt Accessions	Q7TPM3, Q99PP8	Gene names	Trim17
Domain Architecture
Description	Tripartite motif-containing protein 17.

RIPK2_MOUSE
θ value	0.0193708 (rank : 49)	NC score	0.017243 (rank : 226)
Query Neighborhood Hits	142	Target Neighborhood Hits	776	Shared Neighborhood Hits	9
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

CASP1_HUMAN
θ value	0.0330416 (rank : 50)	NC score	0.059707 (rank : 188)
Query Neighborhood Hits	142	Target Neighborhood Hits	41	Shared Neighborhood Hits	11
SwissProt Accessions	P29466, Q9UCN3	Gene names	CASP1, IL1BC, IL1BCE
Domain Architecture
Description	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].

CBLC_MOUSE
θ value	0.0330416 (rank : 51)	NC score	0.201753 (rank : 34)
Query Neighborhood Hits	142	Target Neighborhood Hits	186	Shared Neighborhood Hits	74
SwissProt Accessions	Q80XL1, Q99PB6, Q9D6L2, Q9D7A9	Gene names	Cblc, Cbl3
Domain Architecture	No domain graphic available
Description	Signal transduction protein CBL-C (SH3-binding protein CBL-C) (CBL-3).

RIPK2_HUMAN
θ value	0.0563607 (rank : 52)	NC score	0.015734 (rank : 227)
Query Neighborhood Hits	142	Target Neighborhood Hits	774	Shared Neighborhood Hits	9
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

CARD4_HUMAN
θ value	0.0961366 (rank : 53)	NC score	0.047598 (rank : 212)
Query Neighborhood Hits	142	Target Neighborhood Hits	102	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y239, Q8IWF5	Gene names	CARD4, NOD1
Domain Architecture
Description	Caspase recruitment domain-containing protein 4 (Protein Nod1).

STON2_HUMAN
θ value	0.0961366 (rank : 54)	NC score	0.026517 (rank : 224)
Query Neighborhood Hits	142	Target Neighborhood Hits	115	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WXE9, Q6NT47, Q96RI7, Q96RU6	Gene names	STON2, STN2, STNB
Domain Architecture
Description	Stonin-2 (Stoned B).

CBLC_HUMAN
θ value	0.125558 (rank : 55)	NC score	0.186819 (rank : 40)
Query Neighborhood Hits	142	Target Neighborhood Hits	173	Shared Neighborhood Hits	75
SwissProt Accessions	Q9ULV8, Q8N1E5, Q9Y5Z2, Q9Y5Z3	Gene names	CBLC, CBL3, RNF57
Domain Architecture
Description	Signal transduction protein CBL-C (SH3-binding protein CBL-C) (CBL-3) (RING finger protein 57).

PEX10_HUMAN
θ value	0.125558 (rank : 56)	NC score	0.183138 (rank : 41)
Query Neighborhood Hits	142	Target Neighborhood Hits	255	Shared Neighborhood Hits	90
SwissProt Accessions	O60683, Q5T095, Q9BW90	Gene names	PEX10, RNF69
Domain Architecture
Description	Peroxisome assembly protein 10 (Peroxin-10) (Peroxisome biogenesis factor 10) (RING finger protein 69).

TRI11_HUMAN
θ value	0.125558 (rank : 57)	NC score	0.121593 (rank : 74)
Query Neighborhood Hits	142	Target Neighborhood Hits	316	Shared Neighborhood Hits	94
SwissProt Accessions	Q96F44, Q8NCA6, Q9C022	Gene names	TRIM11, RNF92
Domain Architecture
Description	Tripartite motif-containing protein 11 (EC 6.3.2.-) (RING finger protein 92) (Protein BIA1).

TRI11_MOUSE
θ value	0.125558 (rank : 58)	NC score	0.123110 (rank : 72)
Query Neighborhood Hits	142	Target Neighborhood Hits	329	Shared Neighborhood Hits	94
SwissProt Accessions	Q99PQ2, Q8VDX5	Gene names	Trim11
Domain Architecture
Description	Tripartite motif-containing protein 11 (EC 6.3.2.-).

TRI12_MOUSE
θ value	0.125558 (rank : 59)	NC score	0.133928 (rank : 62)
Query Neighborhood Hits	142	Target Neighborhood Hits	387	Shared Neighborhood Hits	89
SwissProt Accessions	Q99PQ1, Q9D704	Gene names	Trim12
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 12.

TRI17_HUMAN
θ value	0.125558 (rank : 60)	NC score	0.126669 (rank : 69)
Query Neighborhood Hits	142	Target Neighborhood Hits	318	Shared Neighborhood Hits	90
SwissProt Accessions	Q9Y577	Gene names	TRIM17, RBCC, RNF16, TERF
Domain Architecture
Description	Tripartite motif-containing protein 17 (Testis RING finger protein) (RING finger protein 16).

TRI31_HUMAN
θ value	0.125558 (rank : 61)	NC score	0.156921 (rank : 49)
Query Neighborhood Hits	142	Target Neighborhood Hits	299	Shared Neighborhood Hits	90
SwissProt Accessions	Q9BZY9, Q53H52, Q5RI37, Q5SRJ7, Q5SRJ8, Q5SS28, Q96AK4, Q96AP8, Q99579, Q9BZY8	Gene names	TRIM31, C6orf13, RNF
Domain Architecture
Description	Tripartite motif-containing protein 31.

SIA1A_MOUSE
θ value	0.163984 (rank : 62)	NC score	0.138302 (rank : 59)
Query Neighborhood Hits	142	Target Neighborhood Hits	72	Shared Neighborhood Hits	32
SwissProt Accessions	P61092, Q06984	Gene names	Siah1a
Domain Architecture
Description	Ubiquitin ligase SIAH1A (EC 6.3.2.-) (Seven in absentia homolog 1a) (Siah1a) (Siah-1a) (mSiah-1a).

SIA1B_MOUSE
θ value	0.163984 (rank : 63)	NC score	0.139786 (rank : 57)
Query Neighborhood Hits	142	Target Neighborhood Hits	69	Shared Neighborhood Hits	32
SwissProt Accessions	Q06985, Q7TPV6	Gene names	Siah1b
Domain Architecture
Description	Ubiquitin ligase SIAH1B (EC 6.3.2.-) (Seven in absentia homolog 1b) (Siah1b) (Siah-1b).

SIAH1_HUMAN
θ value	0.163984 (rank : 64)	NC score	0.138262 (rank : 60)
Query Neighborhood Hits	142	Target Neighborhood Hits	72	Shared Neighborhood Hits	32
SwissProt Accessions	Q8IUQ4, O43269, Q92880	Gene names	SIAH1, HUMSIAH
Domain Architecture
Description	Ubiquitin ligase SIAH1 (EC 6.3.2.-) (Seven in absentia homolog 1) (Siah-1) (Siah-1a).

SIAH2_HUMAN
θ value	0.163984 (rank : 65)	NC score	0.152243 (rank : 52)
Query Neighborhood Hits	142	Target Neighborhood Hits	94	Shared Neighborhood Hits	43
SwissProt Accessions	O43255, O43270	Gene names	SIAH2
Domain Architecture
Description	Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (hSiah2).

SIAH2_MOUSE
θ value	0.163984 (rank : 66)	NC score	0.153189 (rank : 50)
Query Neighborhood Hits	142	Target Neighborhood Hits	101	Shared Neighborhood Hits	43
SwissProt Accessions	Q06986	Gene names	Siah2
Domain Architecture
Description	Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (mSiah2).

RYR3_HUMAN
θ value	0.21417 (rank : 67)	NC score	0.022079 (rank : 225)
Query Neighborhood Hits	142	Target Neighborhood Hits	134	Shared Neighborhood Hits	4
SwissProt Accessions	Q15413, O15175, Q15412	Gene names	RYR3, HBRR
Domain Architecture
Description	Ryanodine receptor 3 (Brain-type ryanodine receptor) (RyR3) (RYR-3) (Brain ryanodine receptor-calcium release channel).

TRI27_MOUSE
θ value	0.21417 (rank : 68)	NC score	0.124138 (rank : 71)
Query Neighborhood Hits	142	Target Neighborhood Hits	261	Shared Neighborhood Hits	96
SwissProt Accessions	Q62158, Q62157, Q8C2Q5, Q99LK1	Gene names	Trim27, Rfp
Domain Architecture
Description	Zinc finger protein RFP (Ret finger protein) (Tripartite motif- containing protein 27).

MDM2_HUMAN
θ value	0.365318 (rank : 69)	NC score	0.152249 (rank : 51)
Query Neighborhood Hits	142	Target Neighborhood Hits	92	Shared Neighborhood Hits	26
SwissProt Accessions	Q00987, Q13226, Q13297, Q13298, Q13299, Q13300, Q13301, Q53XW0, Q71TW9, Q9UGI3, Q9UMT8	Gene names	MDM2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2).

ZN313_HUMAN
θ value	0.365318 (rank : 70)	NC score	0.127958 (rank : 68)
Query Neighborhood Hits	142	Target Neighborhood Hits	264	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Y508, Q6N0B0	Gene names	ZNF313, RNF114, ZNF228
Domain Architecture
Description	Zinc finger protein 313 (RING finger protein 114).

TRI34_MOUSE
θ value	0.47712 (rank : 71)	NC score	0.107403 (rank : 94)
Query Neighborhood Hits	142	Target Neighborhood Hits	332	Shared Neighborhood Hits	72
SwissProt Accessions	Q99PP6, Q99PP4, Q99PP5	Gene names	Trim34
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 34.

TRI43_HUMAN
θ value	0.47712 (rank : 72)	NC score	0.120922 (rank : 76)
Query Neighborhood Hits	142	Target Neighborhood Hits	341	Shared Neighborhood Hits	90
SwissProt Accessions	Q96BQ3	Gene names	TRIM43
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 43.

TRI60_HUMAN
θ value	0.47712 (rank : 73)	NC score	0.120025 (rank : 78)
Query Neighborhood Hits	142	Target Neighborhood Hits	357	Shared Neighborhood Hits	98
SwissProt Accessions	Q495X7, Q8NA35	Gene names	TRIM60, RNF129
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 60 (RING finger protein 129).

ZN313_MOUSE
θ value	0.47712 (rank : 74)	NC score	0.130769 (rank : 64)
Query Neighborhood Hits	142	Target Neighborhood Hits	273	Shared Neighborhood Hits	89
SwissProt Accessions	Q9ET26, Q3UFU8, Q8K5A2	Gene names	Znf313, Zfp228, Zfp313, Znf228
Domain Architecture
Description	Zinc finger protein 313.

LAMC2_HUMAN
θ value	0.62314 (rank : 75)	NC score	0.010733 (rank : 229)
Query Neighborhood Hits	142	Target Neighborhood Hits	715	Shared Neighborhood Hits	7
SwissProt Accessions	Q13753, Q02536, Q02537, Q13752, Q14941, Q5VYE8	Gene names	LAMC2
Domain Architecture
Description	Laminin gamma-2 chain precursor (Laminin 5 gamma 2 subunit) (Kalinin/nicein/epiligrin 100 kDa subunit) (Laminin B2t chain) (Cell- scattering factor 140 kDa subunit) (CSF 140 kDa subunit) (Large adhesive scatter factor 140 kDa subunit) (Ladsin 140 kDa subunit).

TRIM5_HUMAN
θ value	0.62314 (rank : 76)	NC score	0.113771 (rank : 84)
Query Neighborhood Hits	142	Target Neighborhood Hits	424	Shared Neighborhood Hits	91
SwissProt Accessions	Q9C035, Q8WU46, Q96SR5, Q9C031, Q9C032, Q9C033, Q9C034	Gene names	TRIM5, RNF88
Domain Architecture
Description	Tripartite motif-containing protein 5 (EC 6.3.2.-) (RING finger protein 88).

ATP7B_MOUSE
θ value	0.813845 (rank : 77)	NC score	0.012735 (rank : 228)
Query Neighborhood Hits	142	Target Neighborhood Hits	66	Shared Neighborhood Hits	2
SwissProt Accessions	Q64446	Gene names	Atp7b, Wnd
Domain Architecture
Description	Copper-transporting ATPase 2 (EC 3.6.3.4) (Copper pump 2) (Wilson disease-associated protein homolog).

BRE1B_HUMAN
θ value	0.813845 (rank : 78)	NC score	0.042942 (rank : 216)
Query Neighborhood Hits	142	Target Neighborhood Hits	1040	Shared Neighborhood Hits	75
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

BRE1B_MOUSE
θ value	0.813845 (rank : 79)	NC score	0.044790 (rank : 215)
Query Neighborhood Hits	142	Target Neighborhood Hits	970	Shared Neighborhood Hits	74
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

CARD6_HUMAN
θ value	0.813845 (rank : 80)	NC score	0.047474 (rank : 213)
Query Neighborhood Hits	142	Target Neighborhood Hits	145	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BX69	Gene names	CARD6
Domain Architecture
Description	Caspase recruitment domain-containing protein 6.

TRI27_HUMAN
θ value	0.813845 (rank : 81)	NC score	0.115553 (rank : 82)
Query Neighborhood Hits	142	Target Neighborhood Hits	273	Shared Neighborhood Hits	94
SwissProt Accessions	P14373, Q5ST26, Q6LA73, Q6NXR9, Q9BZY6, Q9UJL3	Gene names	TRIM27, RFP, RNF76
Domain Architecture
Description	Zinc finger protein RFP (Ret finger protein) (Tripartite motif- containing protein 27) (RING finger protein 76).

TRI50_HUMAN
θ value	0.813845 (rank : 82)	NC score	0.124167 (rank : 70)
Query Neighborhood Hits	142	Target Neighborhood Hits	294	Shared Neighborhood Hits	99
SwissProt Accessions	Q86XT4, Q86XT3	Gene names	TRIM50, TRIM50A
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 50.

TRI50_MOUSE
θ value	0.813845 (rank : 83)	NC score	0.130869 (rank : 63)
Query Neighborhood Hits	142	Target Neighborhood Hits	326	Shared Neighborhood Hits	103
SwissProt Accessions	Q810I2	Gene names	Trim50
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 50.

BRE1A_HUMAN
θ value	1.06291 (rank : 84)	NC score	0.031974 (rank : 222)
Query Neighborhood Hits	142	Target Neighborhood Hits	1071	Shared Neighborhood Hits	65
SwissProt Accessions	Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83	Gene names	RNF20, BRE1A
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (hBRE1) (RING finger protein 20).

BRE1A_MOUSE
θ value	1.06291 (rank : 85)	NC score	0.030918 (rank : 223)
Query Neighborhood Hits	142	Target Neighborhood Hits	1025	Shared Neighborhood Hits	62
SwissProt Accessions	Q5DTM8, Q3UT10, Q3V350, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4	Gene names	Rnf20, Bre1a, Kiaa4116
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (RING finger protein 20).

CASP1_MOUSE
θ value	1.06291 (rank : 86)	NC score	0.044843 (rank : 214)
Query Neighborhood Hits	142	Target Neighborhood Hits	38	Shared Neighborhood Hits	11
SwissProt Accessions	P29452	Gene names	Casp1, Il1bc
Domain Architecture
Description	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].

CASP2_HUMAN
θ value	1.06291 (rank : 87)	NC score	0.041302 (rank : 217)
Query Neighborhood Hits	142	Target Neighborhood Hits	31	Shared Neighborhood Hits	8
SwissProt Accessions	P42575, P42576, Q59F21, Q7KZL6, Q86UJ3, Q9BUP7, Q9BZK9	Gene names	CASP2, ICH1
Domain Architecture
Description	Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (ICH- 1L/1S) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].

CASP2_MOUSE
θ value	1.06291 (rank : 88)	NC score	0.040141 (rank : 218)
Query Neighborhood Hits	142	Target Neighborhood Hits	34	Shared Neighborhood Hits	6
SwissProt Accessions	P29594, O08737, Q3TCM0, Q8C9H7, Q8K241	Gene names	Casp2, Ich1, Nedd-2, Nedd2
Domain Architecture
Description	Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural precursor cell expressed developmentally down- regulated protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].

TRI68_MOUSE
θ value	1.06291 (rank : 89)	NC score	0.111174 (rank : 87)
Query Neighborhood Hits	142	Target Neighborhood Hits	356	Shared Neighborhood Hits	89
SwissProt Accessions	Q8K243	Gene names	Trim68, Rnf137
Domain Architecture	No domain graphic available
Description	Tripartite motif containing protein 68 (Ring finger protein 137).

MDM2_MOUSE
θ value	1.38821 (rank : 90)	NC score	0.129310 (rank : 66)
Query Neighborhood Hits	142	Target Neighborhood Hits	77	Shared Neighborhood Hits	27
SwissProt Accessions	P23804, Q61040, Q64330	Gene names	Mdm2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein).

TRI25_MOUSE
θ value	1.38821 (rank : 91)	NC score	0.102093 (rank : 102)
Query Neighborhood Hits	142	Target Neighborhood Hits	446	Shared Neighborhood Hits	90
SwissProt Accessions	Q61510	Gene names	Trim25, Efp, Zfp147, Znf147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp).

TRI56_MOUSE
θ value	1.38821 (rank : 92)	NC score	0.077412 (rank : 133)
Query Neighborhood Hits	142	Target Neighborhood Hits	255	Shared Neighborhood Hits	73
SwissProt Accessions	Q80VI1, Q8CAY0	Gene names	Trim56
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 56.

RN168_HUMAN
θ value	1.81305 (rank : 93)	NC score	0.139668 (rank : 58)
Query Neighborhood Hits	142	Target Neighborhood Hits	370	Shared Neighborhood Hits	93
SwissProt Accessions	Q8IYW5, Q8NA67, Q96NS4	Gene names	RNF168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

TRI52_HUMAN
θ value	1.81305 (rank : 94)	NC score	0.137299 (rank : 61)
Query Neighborhood Hits	142	Target Neighborhood Hits	213	Shared Neighborhood Hits	76
SwissProt Accessions	Q96A61	Gene names	TRIM52, RNF102
Domain Architecture
Description	Tripartite motif-containing protein 52 (RING finger protein 102).

TRI73_HUMAN
θ value	1.81305 (rank : 95)	NC score	0.129904 (rank : 65)
Query Neighborhood Hits	142	Target Neighborhood Hits	258	Shared Neighborhood Hits	94
SwissProt Accessions	Q86UV7, Q8N0S3	Gene names	TRIM73, TRIM50B
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 73 (Tripartite motif-containing protein 50B).

TRIM6_HUMAN
θ value	1.81305 (rank : 96)	NC score	0.103087 (rank : 100)
Query Neighborhood Hits	142	Target Neighborhood Hits	412	Shared Neighborhood Hits	79
SwissProt Accessions	Q9C030, Q86WZ8, Q9HCR1	Gene names	TRIM6, RNF89
Domain Architecture
Description	Tripartite motif-containing protein 6 (RING finger protein 89).

CARD4_MOUSE
θ value	2.36792 (rank : 97)	NC score	0.055276 (rank : 207)
Query Neighborhood Hits	142	Target Neighborhood Hits	85	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BHB0, Q8BUT6	Gene names	Card4
Domain Architecture
Description	Caspase recruitment domain-containing protein 4.

SMRA3_MOUSE
θ value	2.36792 (rank : 98)	NC score	0.081655 (rank : 129)
Query Neighborhood Hits	142	Target Neighborhood Hits	267	Shared Neighborhood Hits	87
SwissProt Accessions	Q6PCN7, O35596, O35597, Q80VT6	Gene names	Smarca3, Snf2l3, Zbu1
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 3) (TNF-response element-binding protein) (P113).

TRI15_HUMAN
θ value	2.36792 (rank : 99)	NC score	0.110911 (rank : 88)
Query Neighborhood Hits	142	Target Neighborhood Hits	395	Shared Neighborhood Hits	80
SwissProt Accessions	Q9C019, O95604, Q8IUX9, Q9C018	Gene names	TRIM15, RNF93, ZNF178, ZNFB7
Domain Architecture
Description	Tripartite motif-containing protein 15 (Zinc finger protein B7) (RING finger protein 93) (Zinc finger protein 178).

TRI34_HUMAN
θ value	2.36792 (rank : 100)	NC score	0.106009 (rank : 96)
Query Neighborhood Hits	142	Target Neighborhood Hits	416	Shared Neighborhood Hits	80
SwissProt Accessions	Q9BYJ4, Q9C016, Q9HCR0, Q9HCR1, Q9HCR2	Gene names	TRIM34, IFP1, RNF21
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 34 (Interferon-responsive finger protein 1) (RING finger protein 21).

TRIM4_HUMAN
θ value	2.36792 (rank : 101)	NC score	0.115324 (rank : 83)
Query Neighborhood Hits	142	Target Neighborhood Hits	321	Shared Neighborhood Hits	93
SwissProt Accessions	Q9C037, Q96F06, Q9C036	Gene names	TRIM4, RNF87
Domain Architecture
Description	Tripartite motif-containing protein 4 (RING finger protein 87).

ZC3H5_HUMAN
θ value	2.36792 (rank : 102)	NC score	0.074620 (rank : 138)
Query Neighborhood Hits	142	Target Neighborhood Hits	134	Shared Neighborhood Hits	20
SwissProt Accessions	Q9C0B0	Gene names	ZC3H5, KIAA1753, ZC3HDC5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

ZC3H5_MOUSE
θ value	2.36792 (rank : 103)	NC score	0.075010 (rank : 136)
Query Neighborhood Hits	142	Target Neighborhood Hits	136	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BL48, Q8BVI6, Q99JZ8, Q99LL9	Gene names	Zc3h5, Kiaa1753, Zc3hdc5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

RN185_HUMAN
θ value	3.0926 (rank : 104)	NC score	0.146678 (rank : 54)
Query Neighborhood Hits	142	Target Neighborhood Hits	213	Shared Neighborhood Hits	88
SwissProt Accessions	Q96GF1, Q8N900	Gene names	RNF185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

RN185_MOUSE
θ value	3.0926 (rank : 105)	NC score	0.145509 (rank : 55)
Query Neighborhood Hits	142	Target Neighborhood Hits	211	Shared Neighborhood Hits	88
SwissProt Accessions	Q91YT2, Q6ZWS3	Gene names	Rnf185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

TRI38_HUMAN
θ value	3.0926 (rank : 106)	NC score	0.097131 (rank : 106)
Query Neighborhood Hits	142	Target Neighborhood Hits	373	Shared Neighborhood Hits	75
SwissProt Accessions	O00635	Gene names	TRIM38, RNF15, RORET
Domain Architecture
Description	Tripartite motif-containing protein 38 (RING finger protein 15) (Zinc finger protein RoRet).

TRI39_HUMAN
θ value	3.0926 (rank : 107)	NC score	0.110640 (rank : 89)
Query Neighborhood Hits	142	Target Neighborhood Hits	693	Shared Neighborhood Hits	94
SwissProt Accessions	Q9HCM9, Q76BL3, Q8IYT9, Q96IB6	Gene names	TRIM39, RNF23, TFP
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

TRI39_MOUSE
θ value	3.0926 (rank : 108)	NC score	0.110396 (rank : 90)
Query Neighborhood Hits	142	Target Neighborhood Hits	691	Shared Neighborhood Hits	93
SwissProt Accessions	Q9ESN2, Q8BPR5, Q8K0F7	Gene names	Trim39, Rnf23, Tfp
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

RBBP6_HUMAN
θ value	4.03905 (rank : 109)	NC score	0.035543 (rank : 220)
Query Neighborhood Hits	142	Target Neighborhood Hits	1135	Shared Neighborhood Hits	70
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

RBBP6_MOUSE
θ value	4.03905 (rank : 110)	NC score	0.039333 (rank : 219)
Query Neighborhood Hits	142	Target Neighborhood Hits	1014	Shared Neighborhood Hits	69
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

RN123_HUMAN
θ value	4.03905 (rank : 111)	NC score	0.102292 (rank : 101)
Query Neighborhood Hits	142	Target Neighborhood Hits	175	Shared Neighborhood Hits	69
SwissProt Accessions	Q5XPI4, Q5I022, Q6PFW4, Q71RH0, Q8IW18, Q9H0M8, Q9H5L8, Q9H9T2	Gene names	RNF123, KPC1
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase subunit KPC1 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123).

RN123_MOUSE
θ value	4.03905 (rank : 112)	NC score	0.105640 (rank : 97)
Query Neighborhood Hits	142	Target Neighborhood Hits	174	Shared Neighborhood Hits	71
SwissProt Accessions	Q5XPI3, Q6PGE0	Gene names	Rnf123, Kpc1
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase subunit KPC1 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123).

TRI18_HUMAN
θ value	4.03905 (rank : 113)	NC score	0.070570 (rank : 154)
Query Neighborhood Hits	142	Target Neighborhood Hits	307	Shared Neighborhood Hits	82
SwissProt Accessions	O15344, O75361, Q9BZX5	Gene names	MID1, FXY, RNF59, TRIM18, XPRF
Domain Architecture
Description	Midline-1 (EC 6.3.2.-) (Tripartite motif-containing protein 18) (Putative transcription factor XPRF) (Midin) (RING finger protein 59) (Midline 1 RING finger protein).

TRI18_MOUSE
θ value	4.03905 (rank : 114)	NC score	0.069915 (rank : 158)
Query Neighborhood Hits	142	Target Neighborhood Hits	292	Shared Neighborhood Hits	83
SwissProt Accessions	O70583, O35418, Q7TPT6	Gene names	Mid1, Fxy, Trim18
Domain Architecture
Description	Midline-1 (EC 6.3.2.-) (Tripartite motif-containing protein 18) (Midin).

TRI25_HUMAN
θ value	4.03905 (rank : 115)	NC score	0.084386 (rank : 121)
Query Neighborhood Hits	142	Target Neighborhood Hits	472	Shared Neighborhood Hits	85
SwissProt Accessions	Q14258	Gene names	TRIM25, EFP, RNF147, ZNF147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp) (RING finger protein 147).

TRI35_MOUSE
θ value	4.03905 (rank : 116)	NC score	0.122216 (rank : 73)
Query Neighborhood Hits	142	Target Neighborhood Hits	465	Shared Neighborhood Hits	95
SwissProt Accessions	Q8C006, Q6ZPY0, Q7TQL7, Q810V7, Q8BVY9, Q8VID4, Q9CW74, Q9D208	Gene names	Trim35, Hls5, Kiaa1098, Mair
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 35 (Macrophage-derived apoptosis- inducing RBCC protein) (Protein MAIR) (Protein Nc8) (Hemopoietic lineage switch protein 5).

TRI41_HUMAN
θ value	4.03905 (rank : 117)	NC score	0.105076 (rank : 98)
Query Neighborhood Hits	142	Target Neighborhood Hits	349	Shared Neighborhood Hits	73
SwissProt Accessions	Q8WV44, Q5BKT0, Q7L484, Q96Q10, Q9BSL8	Gene names	TRIM41
Domain Architecture
Description	Tripartite motif-containing protein 41.

TRI56_HUMAN
θ value	4.03905 (rank : 118)	NC score	0.088699 (rank : 116)
Query Neighborhood Hits	142	Target Neighborhood Hits	339	Shared Neighborhood Hits	80
SwissProt Accessions	Q9BRZ2, Q86VT6, Q8N2H8, Q8NAC0, Q9H031	Gene names	TRIM56, RNF109
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 56 (RING finger protein 109).

TRI65_HUMAN
θ value	4.03905 (rank : 119)	NC score	0.108082 (rank : 93)
Query Neighborhood Hits	142	Target Neighborhood Hits	330	Shared Neighborhood Hits	86
SwissProt Accessions	Q6PJ69, Q4G0F0, Q6DKJ6, Q9BRP6	Gene names	TRIM65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

TRI74_HUMAN
θ value	4.03905 (rank : 120)	NC score	0.118692 (rank : 80)
Query Neighborhood Hits	142	Target Neighborhood Hits	249	Shared Neighborhood Hits	91
SwissProt Accessions	Q86UV6	Gene names	TRIM74, TRIM50C
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 74 (Tripartite motif-containing protein 50C).

RN168_MOUSE
θ value	5.27518 (rank : 121)	NC score	0.106073 (rank : 95)
Query Neighborhood Hits	142	Target Neighborhood Hits	440	Shared Neighborhood Hits	90
SwissProt Accessions	Q80XJ2	Gene names	Rnf168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

RNF8_HUMAN
θ value	5.27518 (rank : 122)	NC score	0.112417 (rank : 86)
Query Neighborhood Hits	142	Target Neighborhood Hits	622	Shared Neighborhood Hits	102
SwissProt Accessions	O76064	Gene names	RNF8, KIAA0646
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8).

SMC4_HUMAN
θ value	5.27518 (rank : 123)	NC score	0.002035 (rank : 234)
Query Neighborhood Hits	142	Target Neighborhood Hits	937	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

TRI46_HUMAN
θ value	5.27518 (rank : 124)	NC score	0.070653 (rank : 152)
Query Neighborhood Hits	142	Target Neighborhood Hits	291	Shared Neighborhood Hits	77
SwissProt Accessions	Q7Z4K8, Q6NT17, Q6NT41, Q6ZRL7, Q9H5P2	Gene names	TRIM46, TRIFIC
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 46 (Tripartite, fibronectin type- III and C-terminal SPRY motif protein).

TRI46_MOUSE
θ value	5.27518 (rank : 125)	NC score	0.070150 (rank : 157)
Query Neighborhood Hits	142	Target Neighborhood Hits	287	Shared Neighborhood Hits	76
SwissProt Accessions	Q7TNM2, Q60717, Q6P1I9	Gene names	Trim46, Trific
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 46 (Tripartite, fibronectin type- III and C-terminal SPRY motif protein).

TRI48_HUMAN
θ value	5.27518 (rank : 126)	NC score	0.104928 (rank : 99)
Query Neighborhood Hits	142	Target Neighborhood Hits	192	Shared Neighborhood Hits	70
SwissProt Accessions	Q8IWZ4, Q9BUW4	Gene names	TRIM48, RNF101
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 48 (RING finger protein 101).

TRIM1_HUMAN
θ value	5.27518 (rank : 127)	NC score	0.065199 (rank : 175)
Query Neighborhood Hits	142	Target Neighborhood Hits	345	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UJV3, Q5JYF5, Q8WWK1, Q9UJR9	Gene names	MID2, FXY2, RNF60, TRIM1
Domain Architecture
Description	Midline-2 (Midline defect 2) (Tripartite motif-containing protein 1) (Midin-2) (RING finger protein 60).

TRIM1_MOUSE
θ value	5.27518 (rank : 128)	NC score	0.064241 (rank : 176)
Query Neighborhood Hits	142	Target Neighborhood Hits	361	Shared Neighborhood Hits	85
SwissProt Accessions	Q9QUS6	Gene names	Mid2, Fxy2, Trim1
Domain Architecture
Description	Midline-2 (Midline defect 2) (Tripartite motif-containing protein 1).

ADCK1_HUMAN
θ value	6.88961 (rank : 129)	NC score	0.009249 (rank : 230)
Query Neighborhood Hits	142	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	Q86TW2, Q6PD65	Gene names	ADCK1
Domain Architecture	No domain graphic available
Description	Uncharacterized aarF domain-containing protein kinase 1 precursor (EC 2.7.-.-).

DYH11_HUMAN
θ value	6.88961 (rank : 130)	NC score	0.004778 (rank : 233)
Query Neighborhood Hits	142	Target Neighborhood Hits	234	Shared Neighborhood Hits	5
SwissProt Accessions	Q96DT5, Q9UJ82	Gene names	DNAH11
Domain Architecture
Description	Ciliary dynein heavy chain 11 (Axonemal beta dynein heavy chain 11).

FANCJ_MOUSE
θ value	6.88961 (rank : 131)	NC score	0.007081 (rank : 231)
Query Neighborhood Hits	142	Target Neighborhood Hits	57	Shared Neighborhood Hits	3
SwissProt Accessions	Q5SXJ3, Q8BJQ8, Q8BKI6	Gene names	Brip1, Bach1, Fancj
Domain Architecture	No domain graphic available
Description	Fanconi anemia group J protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase BRIP1) (Protein FACJ) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (BRCA1-associated C-terminal helicase 1).

PZRN4_HUMAN
θ value	6.88961 (rank : 132)	NC score	0.033961 (rank : 221)
Query Neighborhood Hits	142	Target Neighborhood Hits	438	Shared Neighborhood Hits	78
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

RNF5_HUMAN
θ value	6.88961 (rank : 133)	NC score	0.121171 (rank : 75)
Query Neighborhood Hits	142	Target Neighborhood Hits	206	Shared Neighborhood Hits	87
SwissProt Accessions	Q99942, Q9UMQ2	Gene names	RNF5, G16, NG2, RMA1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (HsRma1) (RING finger protein 5) (Protein G16).

RNF5_MOUSE
θ value	6.88961 (rank : 134)	NC score	0.120136 (rank : 77)
Query Neighborhood Hits	142	Target Neighborhood Hits	206	Shared Neighborhood Hits	87
SwissProt Accessions	O35445	Gene names	Rnf5, Ng2
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (RING finger protein 5).

TRI59_MOUSE
θ value	6.88961 (rank : 135)	NC score	0.078206 (rank : 132)
Query Neighborhood Hits	142	Target Neighborhood Hits	292	Shared Neighborhood Hits	73
SwissProt Accessions	Q922Y2, Q9CSP2, Q9CUD5, Q9D740	Gene names	Trim59, Mrf1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 59 (RING finger protein 1).

TRI65_MOUSE
θ value	6.88961 (rank : 136)	NC score	0.109409 (rank : 91)
Query Neighborhood Hits	142	Target Neighborhood Hits	340	Shared Neighborhood Hits	94
SwissProt Accessions	Q8BFW4, Q6PGD3	Gene names	Trim65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

ESCO2_MOUSE
θ value	8.99809 (rank : 137)	NC score	0.006529 (rank : 232)
Query Neighborhood Hits	142	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CIB9, Q3UMT6, Q6IQX5, Q8BNG9, Q8BQF8, Q9CRI8	Gene names	Esco2
Domain Architecture	No domain graphic available
Description	N-acetyltransferase ESCO2 (EC 2.3.1.-) (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2).

MYH9_MOUSE
θ value	8.99809 (rank : 138)	NC score	0.000940 (rank : 235)
Query Neighborhood Hits	142	Target Neighborhood Hits	1829	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

SMRA3_HUMAN
θ value	8.99809 (rank : 139)	NC score	0.061758 (rank : 180)
Query Neighborhood Hits	142	Target Neighborhood Hits	265	Shared Neighborhood Hits	85
SwissProt Accessions	Q14527, Q14536, Q16051, Q7KYJ6, Q86YA5, Q92652, Q96KM9	Gene names	SMARCA3, HIP116A, HLTF, SNF2L3, ZBU1
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 3) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (Helicase-like transcription factor) (HIP116).

TRI22_HUMAN
θ value	8.99809 (rank : 140)	NC score	0.098401 (rank : 105)
Query Neighborhood Hits	142	Target Neighborhood Hits	396	Shared Neighborhood Hits	78
SwissProt Accessions	Q8IYM9, Q15521	Gene names	TRIM22, RNF94, STAF50
Domain Architecture
Description	Tripartite motif-containing protein 22 (RING finger protein 94) (50 kDa-stimulated trans-acting factor) (Staf-50).

TRI35_HUMAN
θ value	8.99809 (rank : 141)	NC score	0.113446 (rank : 85)
Query Neighborhood Hits	142	Target Neighborhood Hits	382	Shared Neighborhood Hits	94
SwissProt Accessions	Q9UPQ4, Q86XQ0, Q8WVA4	Gene names	TRIM35, HLS5, KIAA1098
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 35 (Hemopoietic lineage switch protein 5).

TRIM6_MOUSE
θ value	8.99809 (rank : 142)	NC score	0.098693 (rank : 104)
Query Neighborhood Hits	142	Target Neighborhood Hits	451	Shared Neighborhood Hits	75
SwissProt Accessions	Q8BGE7, Q99PQ6	Gene names	Trim6
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 6.

BFAR_HUMAN
θ value	θ > 10 (rank : 143)	NC score	0.069547 (rank : 161)
Query Neighborhood Hits	142	Target Neighborhood Hits	222	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NZS9	Gene names	BFAR, BAR, RNF47
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator (RING finger protein 47).

BFAR_MOUSE
θ value	θ > 10 (rank : 144)	NC score	0.070546 (rank : 155)
Query Neighborhood Hits	142	Target Neighborhood Hits	232	Shared Neighborhood Hits	74
SwissProt Accessions	Q8R079, Q8C1A7, Q9CXY3	Gene names	Bfar
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator.

BRCA1_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.073747 (rank : 141)
Query Neighborhood Hits	142	Target Neighborhood Hits	381	Shared Neighborhood Hits	87
SwissProt Accessions	P38398	Gene names	BRCA1, RNF53
Domain Architecture
Description	Breast cancer type 1 susceptibility protein (RING finger protein 53).

BRCA1_MOUSE
θ value	θ > 10 (rank : 146)	NC score	0.076307 (rank : 134)
Query Neighborhood Hits	142	Target Neighborhood Hits	436	Shared Neighborhood Hits	88
SwissProt Accessions	P48754, Q60957, Q60983	Gene names	Brca1
Domain Architecture
Description	Breast cancer type 1 susceptibility protein homolog.

BSPRY_HUMAN
θ value	θ > 10 (rank : 147)	NC score	0.060713 (rank : 181)
Query Neighborhood Hits	142	Target Neighborhood Hits	115	Shared Neighborhood Hits	44
SwissProt Accessions	Q5W0U4, Q96DJ2, Q9H4E4, Q9NXN0	Gene names	BSPRY
Domain Architecture	No domain graphic available
Description	B box and SPRY domain-containing protein.

BSPRY_MOUSE
θ value	θ > 10 (rank : 148)	NC score	0.061970 (rank : 179)
Query Neighborhood Hits	142	Target Neighborhood Hits	163	Shared Neighborhood Hits	45
SwissProt Accessions	Q80YW5, Q3TU74, Q8BZF0, Q99KV7, Q9ER70	Gene names	Bspry
Domain Architecture	No domain graphic available
Description	B box and SPRY domain-containing protein.

BT1A1_HUMAN
θ value	θ > 10 (rank : 149)	NC score	0.057328 (rank : 199)
Query Neighborhood Hits	142	Target Neighborhood Hits	322	Shared Neighborhood Hits	40
SwissProt Accessions	Q13410, Q9H458	Gene names	BTN1A1, BTN
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

BT1A1_MOUSE
θ value	θ > 10 (rank : 150)	NC score	0.058752 (rank : 193)
Query Neighborhood Hits	142	Target Neighborhood Hits	252	Shared Neighborhood Hits	40
SwissProt Accessions	Q62556, P97392, Q8K2H7, Q921K7	Gene names	Btn1a1, Btn
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

BT2A1_HUMAN
θ value	θ > 10 (rank : 151)	NC score	0.055600 (rank : 205)
Query Neighborhood Hits	142	Target Neighborhood Hits	185	Shared Neighborhood Hits	38
SwissProt Accessions	Q7KYR7, O00475, P78408, Q7KYQ7, Q7Z386, Q9NU62	Gene names	BTN2A1, BT2.1, BTF1
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A1 precursor.

BT2A2_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.057473 (rank : 198)
Query Neighborhood Hits	142	Target Neighborhood Hits	191	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WVV5, O00480	Gene names	BTN2A2, BT2.2, BTF2
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A2 precursor.

BT2A3_HUMAN
θ value	θ > 10 (rank : 153)	NC score	0.057310 (rank : 200)
Query Neighborhood Hits	142	Target Neighborhood Hits	195	Shared Neighborhood Hits	38
SwissProt Accessions	Q96KV6	Gene names	BTN2A3
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A3 precursor.

BT3A1_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.056208 (rank : 202)
Query Neighborhood Hits	142	Target Neighborhood Hits	229	Shared Neighborhood Hits	40
SwissProt Accessions	O00481, Q99420, Q9HCY1	Gene names	BTN3A1, BTF5
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A1 precursor (CD277 antigen).

BT3A3_HUMAN
θ value	θ > 10 (rank : 155)	NC score	0.056997 (rank : 201)
Query Neighborhood Hits	142	Target Neighborhood Hits	233	Shared Neighborhood Hits	40
SwissProt Accessions	O00478	Gene names	BTN3A3, BTF3
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A3 precursor.

BTNL3_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.057934 (rank : 197)
Query Neighborhood Hits	142	Target Neighborhood Hits	143	Shared Neighborhood Hits	38
SwissProt Accessions	Q6UXE8, Q9Y2C7	Gene names	BTNL3, BTNLR, COLF4100
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 3 precursor (Butyrophilin-like receptor).

BTNL8_HUMAN
θ value	θ > 10 (rank : 157)	NC score	0.055404 (rank : 206)
Query Neighborhood Hits	142	Target Neighborhood Hits	177	Shared Neighborhood Hits	38
SwissProt Accessions	Q6UX41, Q9H730	Gene names	BTNL8
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 8 precursor.

BTNL9_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.055945 (rank : 204)
Query Neighborhood Hits	142	Target Neighborhood Hits	125	Shared Neighborhood Hits	40
SwissProt Accessions	Q6UXG8, Q6P660, Q96DM5	Gene names	BTNL9
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 9 precursor.

CAR15_HUMAN
θ value	θ > 10 (rank : 159)	NC score	0.079426 (rank : 130)
Query Neighborhood Hits	142	Target Neighborhood Hits	77	Shared Neighborhood Hits	14
SwissProt Accessions	Q9HC29, Q96RH5, Q96RH6, Q96RH8	Gene names	CARD15, IBD1, NOD2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1).

CAR15_MOUSE
θ value	θ > 10 (rank : 160)	NC score	0.088097 (rank : 119)
Query Neighborhood Hits	142	Target Neighborhood Hits	93	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K3Z0	Gene names	Card15, Nod2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2).

CHFR_HUMAN
θ value	θ > 10 (rank : 161)	NC score	0.074181 (rank : 139)
Query Neighborhood Hits	142	Target Neighborhood Hits	255	Shared Neighborhood Hits	76
SwissProt Accessions	Q96EP1, Q96SL3, Q9NRT4, Q9NT32, Q9NVD5	Gene names	CHFR
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

CHFR_MOUSE
θ value	θ > 10 (rank : 162)	NC score	0.071822 (rank : 148)
Query Neighborhood Hits	142	Target Neighborhood Hits	264	Shared Neighborhood Hits	79
SwissProt Accessions	Q810L3, Q8BJZ9, Q8BWH4	Gene names	Chfr
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

ERMAP_HUMAN
θ value	θ > 10 (rank : 163)	NC score	0.066643 (rank : 170)
Query Neighborhood Hits	142	Target Neighborhood Hits	155	Shared Neighborhood Hits	40
SwissProt Accessions	Q96PL5, Q5VV53, Q6DUE0, Q7Z3X0, Q8NCV8, Q8NCW2, Q8NCW3, Q96PL6	Gene names	ERMAP, RD, SC
Domain Architecture	No domain graphic available
Description	Erythroid membrane-associated protein precursor (hERMAP) (Scianna blood group antigen) (Radin blood group antigen).

ERMAP_MOUSE
θ value	θ > 10 (rank : 164)	NC score	0.060016 (rank : 185)
Query Neighborhood Hits	142	Target Neighborhood Hits	231	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JLN5, Q3UV82, Q6P4T5, Q8CEH1	Gene names	Ermap
Domain Architecture	No domain graphic available
Description	Erythroid membrane-associated protein precursor.

ICBR_HUMAN
θ value	θ > 10 (rank : 165)	NC score	0.067642 (rank : 167)
Query Neighborhood Hits	142	Target Neighborhood Hits	11	Shared Neighborhood Hits	6
SwissProt Accessions	P57730	Gene names	ICEBERG
Domain Architecture
Description	Caspase-1 inhibitor Iceberg.

LRC31_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.119042 (rank : 79)
Query Neighborhood Hits	142	Target Neighborhood Hits	139	Shared Neighborhood Hits	8
SwissProt Accessions	Q6UY01, Q8N848, Q9H5N5	Gene names	LRRC31
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 31.

MDM4_MOUSE
θ value	θ > 10 (rank : 167)	NC score	0.096904 (rank : 107)
Query Neighborhood Hits	142	Target Neighborhood Hits	36	Shared Neighborhood Hits	16
SwissProt Accessions	O35618	Gene names	Mdm4, Mdmx
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

MEFV_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.075293 (rank : 135)
Query Neighborhood Hits	142	Target Neighborhood Hits	431	Shared Neighborhood Hits	49
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

MEFV_MOUSE
θ value	θ > 10 (rank : 169)	NC score	0.073312 (rank : 142)
Query Neighborhood Hits	142	Target Neighborhood Hits	236	Shared Neighborhood Hits	49
SwissProt Accessions	Q9JJ26	Gene names	Mefv
Domain Architecture
Description	Pyrin (Marenostrin).

NAL10_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.058542 (rank : 195)
Query Neighborhood Hits	142	Target Neighborhood Hits	55	Shared Neighborhood Hits	9
SwissProt Accessions	Q86W26, Q6JGT0	Gene names	NALP10, NOD8, PYNOD
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10 (Nucleotide-binding oligomerization domain protein 8).

NAL10_MOUSE
θ value	θ > 10 (rank : 171)	NC score	0.072625 (rank : 147)
Query Neighborhood Hits	142	Target Neighborhood Hits	46	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CCN1	Gene names	Nalp10, Pynod
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10.

NAL13_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.058619 (rank : 194)
Query Neighborhood Hits	142	Target Neighborhood Hits	93	Shared Neighborhood Hits	9
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

NALP1_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.068462 (rank : 166)
Query Neighborhood Hits	142	Target Neighborhood Hits	138	Shared Neighborhood Hits	9
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

NALP2_HUMAN
θ value	θ > 10 (rank : 174)	NC score	0.063598 (rank : 177)
Query Neighborhood Hits	142	Target Neighborhood Hits	65	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NX02, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3	Gene names	NALP2, NBS1, PAN1, PYPAF2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 2 (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) (Nucleotide-binding site protein 1).

NALP4_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.053742 (rank : 209)
Query Neighborhood Hits	142	Target Neighborhood Hits	81	Shared Neighborhood Hits	10
SwissProt Accessions	Q96MN2, Q86W87, Q96AY6	Gene names	NALP4, PAN2, PYPAF4, RNH2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 4 (PYRIN-containing APAF1-like protein 4) (PAAD and NACHT-containing protein 2) (PYRIN and NACHT- containing protein 2) (Ribonuclease inhibitor 2).

NALP7_HUMAN
θ value	θ > 10 (rank : 176)	NC score	0.057956 (rank : 196)
Query Neighborhood Hits	142	Target Neighborhood Hits	65	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

RFPL1_HUMAN
θ value	θ > 10 (rank : 177)	NC score	0.068619 (rank : 165)
Query Neighborhood Hits	142	Target Neighborhood Hits	119	Shared Neighborhood Hits	49
SwissProt Accessions	O75677, Q6IC06	Gene names	RFPL1, RFPL1L, RNF78
Domain Architecture
Description	Ret finger protein-like 1 (RING finger protein 78).

RFPL2_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.074017 (rank : 140)
Query Neighborhood Hits	142	Target Neighborhood Hits	126	Shared Neighborhood Hits	58
SwissProt Accessions	O75678	Gene names	RFPL2, RNF79
Domain Architecture
Description	Ret finger protein-like 2 (RING finger protein 79).

RFPL3_HUMAN
θ value	θ > 10 (rank : 179)	NC score	0.070418 (rank : 156)
Query Neighborhood Hits	142	Target Neighborhood Hits	134	Shared Neighborhood Hits	55
SwissProt Accessions	O75679, Q6IC04	Gene names	RFPL3
Domain Architecture
Description	Ret finger protein-like 3.

RING1_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.067318 (rank : 168)
Query Neighborhood Hits	142	Target Neighborhood Hits	219	Shared Neighborhood Hits	76
SwissProt Accessions	Q06587, Q5JP96, Q5SQW2, Q86V19	Gene names	RING1, RNF1
Domain Architecture
Description	Polycomb complex protein RING1 (RING finger protein 1).

RING1_MOUSE
θ value	θ > 10 (rank : 181)	NC score	0.066004 (rank : 171)
Query Neighborhood Hits	142	Target Neighborhood Hits	220	Shared Neighborhood Hits	76
SwissProt Accessions	O35730, Q3U242, Q3U333, Q4FK33, Q63ZX8, Q921Z8	Gene names	Ring1, Ring1A, Rnf1
Domain Architecture	No domain graphic available
Description	Polycomb complex protein RING1 (RING finger protein 1) (Transcription repressor Ring1A).

RING2_HUMAN
θ value	θ > 10 (rank : 182)	NC score	0.058924 (rank : 191)
Query Neighborhood Hits	142	Target Neighborhood Hits	201	Shared Neighborhood Hits	73
SwissProt Accessions	Q99496, Q5TEN1, Q5TEN2	Gene names	RNF2, BAP1, DING, HIPI3, RING1B
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein RING2 (EC 6.3.2.-) (RING finger protein 2) (RING finger protein 1B) (RING1b) (RING finger protein BAP-1) (DinG protein) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3).

RING2_MOUSE
θ value	θ > 10 (rank : 183)	NC score	0.058920 (rank : 192)
Query Neighborhood Hits	142	Target Neighborhood Hits	199	Shared Neighborhood Hits	73
SwissProt Accessions	Q9CQJ4, O35699, O35729, Q4FJV5, Q8C1X8	Gene names	Rnf2, DinG, Ring1b
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein RING2 (EC 6.3.2.-) (RING finger protein 2) (RING finger protein 1B) (RING1b).

RN125_HUMAN
θ value	θ > 10 (rank : 184)	NC score	0.084024 (rank : 123)
Query Neighborhood Hits	142	Target Neighborhood Hits	230	Shared Neighborhood Hits	81
SwissProt Accessions	Q96EQ8, Q9NX39	Gene names	RNF125
Domain Architecture	No domain graphic available
Description	RING finger protein 125 (EC 6.3.2.-) (T-cell RING activation protein 1) (TRAC-1).

RN125_MOUSE
θ value	θ > 10 (rank : 185)	NC score	0.082254 (rank : 127)
Query Neighborhood Hits	142	Target Neighborhood Hits	220	Shared Neighborhood Hits	84
SwissProt Accessions	Q9D9R0, Q52KL4, Q8C7F2	Gene names	Rnf125
Domain Architecture	No domain graphic available
Description	RING finger protein 125 (EC 6.3.2.-).

RN141_HUMAN
θ value	θ > 10 (rank : 186)	NC score	0.089445 (rank : 114)
Query Neighborhood Hits	142	Target Neighborhood Hits	199	Shared Neighborhood Hits	68
SwissProt Accessions	Q8WVD5, Q9NZB4	Gene names	RNF141, ZNF230
Domain Architecture	No domain graphic available
Description	RING finger protein 141 (Zinc finger protein 230).

RN141_MOUSE
θ value	θ > 10 (rank : 187)	NC score	0.088968 (rank : 115)
Query Neighborhood Hits	142	Target Neighborhood Hits	200	Shared Neighborhood Hits	68
SwissProt Accessions	Q99MB7, Q9D040, Q9D5C4, Q9D9L0	Gene names	Rnf141, Znf230
Domain Architecture	No domain graphic available
Description	RING finger protein 141 (Zinc finger protein 230).

RN146_HUMAN
θ value	θ > 10 (rank : 188)	NC score	0.059858 (rank : 187)
Query Neighborhood Hits	142	Target Neighborhood Hits	162	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NTX7, Q6FIB2, Q7L8H4, Q96K03, Q9NTX6	Gene names	RNF146
Domain Architecture	No domain graphic available
Description	RING finger protein 146 (Dactylidin).

RN146_MOUSE
θ value	θ > 10 (rank : 189)	NC score	0.059023 (rank : 190)
Query Neighborhood Hits	142	Target Neighborhood Hits	161	Shared Neighborhood Hits	69
SwissProt Accessions	Q9CZW6, Q3TF93	Gene names	Rnf146
Domain Architecture	No domain graphic available
Description	RING finger protein 146.

RN166_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.084342 (rank : 122)
Query Neighborhood Hits	142	Target Neighborhood Hits	240	Shared Neighborhood Hits	82
SwissProt Accessions	Q96A37, Q96DM0	Gene names	RNF166
Domain Architecture	No domain graphic available
Description	RING finger protein 166.

RN166_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.081987 (rank : 128)
Query Neighborhood Hits	142	Target Neighborhood Hits	248	Shared Neighborhood Hits	82
SwissProt Accessions	Q3U9F6	Gene names	Rnf166
Domain Architecture	No domain graphic available
Description	RING finger protein 166.

RN169_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.091040 (rank : 111)
Query Neighborhood Hits	142	Target Neighborhood Hits	203	Shared Neighborhood Hits	66
SwissProt Accessions	Q8NCN4, Q6N015	Gene names	RNF169, KIAA1991
Domain Architecture	No domain graphic available
Description	RING finger protein 169.

RNF39_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.069106 (rank : 163)
Query Neighborhood Hits	142	Target Neighborhood Hits	200	Shared Neighborhood Hits	62
SwissProt Accessions	Q9H2S5, Q5SPM8, Q5SPM9, Q5SPN0, Q5SRJ9, Q5SRK1, Q5SS29, Q9H2S3, Q9H2S4	Gene names	RNF39, HZFW
Domain Architecture	No domain graphic available
Description	RING finger protein 39 (Protein HZFw).

RNF4_HUMAN
θ value	θ > 10 (rank : 194)	NC score	0.066974 (rank : 169)
Query Neighborhood Hits	142	Target Neighborhood Hits	212	Shared Neighborhood Hits	70
SwissProt Accessions	P78317	Gene names	RNF4
Domain Architecture
Description	RING finger protein 4.

RNF4_MOUSE
θ value	θ > 10 (rank : 195)	NC score	0.062777 (rank : 178)
Query Neighborhood Hits	142	Target Neighborhood Hits	212	Shared Neighborhood Hits	70
SwissProt Accessions	Q9QZS2, O35941, Q541Z6	Gene names	Rnf4
Domain Architecture
Description	RING finger protein 4.

RNF8_MOUSE
θ value	θ > 10 (rank : 196)	NC score	0.109301 (rank : 92)
Query Neighborhood Hits	142	Target Neighborhood Hits	618	Shared Neighborhood Hits	103
SwissProt Accessions	Q8VC56, Q9JK13	Gene names	Rnf8
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8) (AIP37) (ActA-interacting protein 37) (LaXp180).

SPRY4_MOUSE
θ value	θ > 10 (rank : 197)	NC score	0.051661 (rank : 211)
Query Neighborhood Hits	142	Target Neighborhood Hits	82	Shared Neighborhood Hits	39
SwissProt Accessions	Q91WK1, Q8BUS6, Q9D651	Gene names	Spryd4
Domain Architecture	No domain graphic available
Description	SPRY domain-containing protein 4.

TRI10_HUMAN
θ value	θ > 10 (rank : 198)	NC score	0.093493 (rank : 109)
Query Neighborhood Hits	142	Target Neighborhood Hits	315	Shared Neighborhood Hits	80
SwissProt Accessions	Q9UDY6, Q86Z08, Q96QB6, Q9C023, Q9C024	Gene names	TRIM10, RFB30, RNF9
Domain Architecture
Description	Tripartite motif-containing protein 10 (RING finger protein 9) (B30- RING finger protein).

TRI10_MOUSE
θ value	θ > 10 (rank : 199)	NC score	0.090814 (rank : 112)
Query Neighborhood Hits	142	Target Neighborhood Hits	285	Shared Neighborhood Hits	81
SwissProt Accessions	Q9WUH5, Q80WA9, Q9CY03	Gene names	Trim10, Herf1, Rnf9
Domain Architecture
Description	Tripartite motif-containing protein 10 (RING finger protein 9) (Hematopoietic RING finger 1).

TRI13_HUMAN
θ value	θ > 10 (rank : 200)	NC score	0.078497 (rank : 131)
Query Neighborhood Hits	142	Target Neighborhood Hits	274	Shared Neighborhood Hits	75
SwissProt Accessions	O60858, Q9BQ47, Q9C021	Gene names	TRIM13, LEU5, RFP2, RNF77
Domain Architecture
Description	Tripartite motif-containing protein 13 (Ret finger protein 2) (Putative tumor suppressor RFP2) (Leukemia-associated protein 5) (B- cell chronic lymphocytic leukemia tumor suppressor Leu5) (RING finger protein 77).

TRI13_MOUSE
θ value	θ > 10 (rank : 201)	NC score	0.082307 (rank : 126)
Query Neighborhood Hits	142	Target Neighborhood Hits	282	Shared Neighborhood Hits	78
SwissProt Accessions	Q9CYB0, Q8CEV0, Q923J0, Q925P1, Q99PQ0	Gene names	Trim13, Rfp2
Domain Architecture
Description	Tripartite motif-containing protein 13 (Ret finger protein 2) (Putative tumor suppressor RFP2).

TRI14_HUMAN
θ value	θ > 10 (rank : 202)	NC score	0.059865 (rank : 186)
Query Neighborhood Hits	142	Target Neighborhood Hits	143	Shared Neighborhood Hits	44
SwissProt Accessions	Q14142, Q9BRD8, Q9C020	Gene names	TRIM14, KIAA0129
Domain Architecture
Description	Tripartite motif-containing protein 14.

TRI14_MOUSE
θ value	θ > 10 (rank : 203)	NC score	0.060091 (rank : 184)
Query Neighborhood Hits	142	Target Neighborhood Hits	137	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BVW3, Q6A0C3, Q762I6, Q9D3G8	Gene names	Trim14, Kiaa0129, Pub
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 14 (PU.1-binding protein).

TRI16_HUMAN
θ value	θ > 10 (rank : 204)	NC score	0.053719 (rank : 210)
Query Neighborhood Hits	142	Target Neighborhood Hits	231	Shared Neighborhood Hits	49
SwissProt Accessions	O95361, Q7Z6I2, Q96BE8, Q96J43	Gene names	TRIM16, EBBP
Domain Architecture
Description	Tripartite motif-containing protein 16 (Estrogen-responsive B box protein).

TRI16_MOUSE
θ value	θ > 10 (rank : 205)	NC score	0.059371 (rank : 189)
Query Neighborhood Hits	142	Target Neighborhood Hits	196	Shared Neighborhood Hits	47
SwissProt Accessions	Q99PP9, Q7TPY6, Q8C332, Q8C6V0	Gene names	Trim16, Ebbp
Domain Architecture
Description	Tripartite motif-containing protein 16 (Estrogen-responsive B box protein).

TRI30_MOUSE
θ value	θ > 10 (rank : 206)	NC score	0.101798 (rank : 103)
Query Neighborhood Hits	142	Target Neighborhood Hits	434	Shared Neighborhood Hits	83
SwissProt Accessions	P15533, Q99K55, Q99PQ7, Q99PQ8, Q99PQ9	Gene names	Trim30, Rpt-1, Rpt1
Domain Architecture
Description	Tripartite motif-containing protein 30 (Down regulatory protein of interleukin 2 receptor).

TRI32_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.070591 (rank : 153)
Query Neighborhood Hits	142	Target Neighborhood Hits	264	Shared Neighborhood Hits	74
SwissProt Accessions	Q13049, Q9NQP8	Gene names	TRIM32, HT2A
Domain Architecture
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-) (Zinc finger protein HT2A) (72 kDa Tat-interacting protein).

TRI32_MOUSE
θ value	θ > 10 (rank : 208)	NC score	0.069701 (rank : 159)
Query Neighborhood Hits	142	Target Neighborhood Hits	271	Shared Neighborhood Hits	74
SwissProt Accessions	Q8CH72, Q8K055	Gene names	Trim32
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-).

TRI37_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.072927 (rank : 144)
Query Neighborhood Hits	142	Target Neighborhood Hits	307	Shared Neighborhood Hits	76
SwissProt Accessions	O94972, Q7Z3E6, Q8IYF7, Q8WYF7	Gene names	TRIM37, KIAA0898, MUL, POB1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37 (Mulibrey nanism protein).

TRI37_MOUSE
θ value	θ > 10 (rank : 210)	NC score	0.072852 (rank : 146)
Query Neighborhood Hits	142	Target Neighborhood Hits	316	Shared Neighborhood Hits	76
SwissProt Accessions	Q6PCX9, Q8CHC5	Gene names	Trim37, Kiaa0898
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37.

TRI40_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.115655 (rank : 81)
Query Neighborhood Hits	142	Target Neighborhood Hits	279	Shared Neighborhood Hits	86
SwissProt Accessions	Q6P9F5, Q8TD96	Gene names	TRIM40, RNF35
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 40 (RING finger protein 35).

TRI44_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.053966 (rank : 208)
Query Neighborhood Hits	142	Target Neighborhood Hits	393	Shared Neighborhood Hits	46
SwissProt Accessions	Q96DX7, Q96QY2, Q9UGK0	Gene names	TRIM44, DIPB
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 44 (Protein DIPB).

TRI44_MOUSE
θ value	θ > 10 (rank : 213)	NC score	0.055967 (rank : 203)
Query Neighborhood Hits	142	Target Neighborhood Hits	327	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QXA7, Q80SV9, Q9JHR8	Gene names	Trim44, Dipb
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 44 (Protein DIPB) (Protein Mc7).

TRI47_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.071510 (rank : 149)
Query Neighborhood Hits	142	Target Neighborhood Hits	286	Shared Neighborhood Hits	77
SwissProt Accessions	Q96LD4, Q96GU5, Q9BRN7	Gene names	TRIM47, GOA, RNF100
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47 (Gene overexpressed in astrocytoma protein) (RING finger protein 100).

TRI47_MOUSE
θ value	θ > 10 (rank : 215)	NC score	0.073022 (rank : 143)
Query Neighborhood Hits	142	Target Neighborhood Hits	295	Shared Neighborhood Hits	79
SwissProt Accessions	Q8C0E3, Q6P249, Q811J7, Q8BVZ8, Q8R1K0, Q8R3Y1	Gene names	Trim47
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47.

TRI49_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.090053 (rank : 113)
Query Neighborhood Hits	142	Target Neighborhood Hits	199	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NS80, Q6DJV1	Gene names	TRIM49, RNF18
Domain Architecture
Description	Tripartite motif-containing protein 49 (RING finger protein 18) (Testis-specific ring-finger protein).

TRI54_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.060483 (rank : 183)
Query Neighborhood Hits	142	Target Neighborhood Hits	209	Shared Neighborhood Hits	61
SwissProt Accessions	Q9BYV2, Q53SY4, Q9BYV3	Gene names	TRIM54, MURF, MURF3, RNF30
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 54 (Muscle-specific RING finger protein 3) (MuRF3) (MURF-3) (Muscle-specific RING finger protein) (MuRF) (RING finger protein 30).

TRI54_MOUSE
θ value	θ > 10 (rank : 218)	NC score	0.060640 (rank : 182)
Query Neighborhood Hits	142	Target Neighborhood Hits	197	Shared Neighborhood Hits	60
SwissProt Accessions	Q9ERP3	Gene names	Trim54, Murf, Rnf30
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 54 (Muscle-specific RING finger protein 3) (MuRF3) (MURF-3) (Muscle-specific RING finger protein) (MuRF) (RING finger protein 30).

TRI55_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.068652 (rank : 164)
Query Neighborhood Hits	142	Target Neighborhood Hits	292	Shared Neighborhood Hits	62
SwissProt Accessions	Q9BYV6, Q53XX3, Q8IUD9, Q8IUE4, Q96DV2, Q96DV3, Q9BYV5	Gene names	TRIM55, MURF2, RNF29
Domain Architecture
Description	Tripartite motif-containing protein 55 (Muscle-specific RING finger protein 2) (MuRF2) (MURF-2) (RING finger protein 29).

TRI59_HUMAN
θ value	θ > 10 (rank : 220)	NC score	0.074996 (rank : 137)
Query Neighborhood Hits	142	Target Neighborhood Hits	307	Shared Neighborhood Hits	72
SwissProt Accessions	Q8IWR1	Gene names	TRIM59, RNF104, TRIM57, TSBF1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 59 (Tumor suppressor TSBF-1) (RING finger protein 104).

TRI60_MOUSE
θ value	θ > 10 (rank : 221)	NC score	0.091680 (rank : 110)
Query Neighborhood Hits	142	Target Neighborhood Hits	240	Shared Neighborhood Hits	76
SwissProt Accessions	Q8VI40, Q3UX74	Gene names	Trim60, 2czf45, Rnf33
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 60 (Ring finger protein 33).

TRI62_HUMAN
θ value	θ > 10 (rank : 222)	NC score	0.082545 (rank : 125)
Query Neighborhood Hits	142	Target Neighborhood Hits	584	Shared Neighborhood Hits	78
SwissProt Accessions	Q9BVG3, Q9NVG0	Gene names	TRIM62
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 62.

TRI62_MOUSE
θ value	θ > 10 (rank : 223)	NC score	0.083666 (rank : 124)
Query Neighborhood Hits	142	Target Neighborhood Hits	478	Shared Neighborhood Hits	78
SwissProt Accessions	Q80V85	Gene names	Trim62
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 62.

TRI63_HUMAN
θ value	θ > 10 (rank : 224)	NC score	0.065398 (rank : 174)
Query Neighborhood Hits	142	Target Neighborhood Hits	298	Shared Neighborhood Hits	62
SwissProt Accessions	Q969Q1, Q5T2I1, Q96BD3, Q96KD9, Q9BYV4	Gene names	TRIM63, IRF, MURF1, RNF28, SMRZ
Domain Architecture
Description	Ubiquitin ligase TRIM63 (EC 6.3.2.-) (Tripartite motif-containing protein 63) (Muscle-specific RING finger protein 1) (MuRF1) (MURF-1) (RING finger protein 28) (Striated muscle RING zinc finger protein) (Iris RING finger protein).

TRI63_MOUSE
θ value	θ > 10 (rank : 225)	NC score	0.065782 (rank : 173)
Query Neighborhood Hits	142	Target Neighborhood Hits	240	Shared Neighborhood Hits	61
SwissProt Accessions	Q38HM4, Q8BWC4	Gene names	Trim63, Murf1, Rf1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase TRIM63 (EC 6.3.2.-) (Tripartite motif-containing protein 63) (Muscle-specific RING finger protein 1) (MuRF1) (MURF-1) (Muscle RING finger protein 1).

TRI68_HUMAN
θ value	θ > 10 (rank : 226)	NC score	0.096395 (rank : 108)
Query Neighborhood Hits	142	Target Neighborhood Hits	267	Shared Neighborhood Hits	79
SwissProt Accessions	Q6AZZ1, Q8WZ70, Q96PF7, Q9H9C2, Q9NW18	Gene names	TRIM68, RNF137, SS56
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 68 (RING finger protein 137) (SSA protein SS-56) (SS-56).

TRIM2_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.069698 (rank : 160)
Query Neighborhood Hits	142	Target Neighborhood Hits	330	Shared Neighborhood Hits	83
SwissProt Accessions	Q9C040, O60272, Q9BSI9, Q9UFZ1	Gene names	TRIM2, KIAA0517, RNF86
Domain Architecture
Description	Tripartite motif-containing protein 2 (RING finger protein 86).

TRIM2_MOUSE
θ value	θ > 10 (rank : 228)	NC score	0.069444 (rank : 162)
Query Neighborhood Hits	142	Target Neighborhood Hits	331	Shared Neighborhood Hits	83
SwissProt Accessions	Q9ESN6, Q3UHP5, Q8C981	Gene names	Trim2, Narf
Domain Architecture
Description	Tripartite motif-containing protein 2 (Neural activity-related RING finger protein).

TRIM3_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.072883 (rank : 145)
Query Neighborhood Hits	142	Target Neighborhood Hits	357	Shared Neighborhood Hits	80
SwissProt Accessions	O75382, Q9C038, Q9C039	Gene names	TRIM3, BERP, RNF22, RNF97
Domain Architecture
Description	Tripartite motif-containing protein 3 (RING finger protein 22) (Brain- expressed RING finger protein) (RING finger protein 97).

TRIM3_MOUSE
θ value	θ > 10 (rank : 230)	NC score	0.065882 (rank : 172)
Query Neighborhood Hits	142	Target Neighborhood Hits	351	Shared Neighborhood Hits	75
SwissProt Accessions	Q9R1R2, Q3UMU5	Gene names	Trim3, Hac1, Rnf22
Domain Architecture
Description	Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1).

TRIM7_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.088258 (rank : 118)
Query Neighborhood Hits	142	Target Neighborhood Hits	336	Shared Neighborhood Hits	68
SwissProt Accessions	Q9C029, Q969F5, Q96F67, Q96J89, Q96J90	Gene names	TRIM7, GNIP, RNF90
Domain Architecture
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein) (RING finger protein 90).

TRIM7_MOUSE
θ value	θ > 10 (rank : 232)	NC score	0.088008 (rank : 120)
Query Neighborhood Hits	142	Target Neighborhood Hits	358	Shared Neighborhood Hits	67
SwissProt Accessions	Q923T7, Q5NCB6, Q99PQ5	Gene names	Trim7, Gnip
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein).

TRIM8_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.070679 (rank : 151)
Query Neighborhood Hits	142	Target Neighborhood Hits	650	Shared Neighborhood Hits	70
SwissProt Accessions	Q9BZR9, Q9C028	Gene names	TRIM8, GERP, RNF27
Domain Architecture
Description	Tripartite motif-containing protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein).

TRIM8_MOUSE
θ value	θ > 10 (rank : 234)	NC score	0.071362 (rank : 150)
Query Neighborhood Hits	142	Target Neighborhood Hits	674	Shared Neighborhood Hits	72
SwissProt Accessions	Q99PJ2, Q8C508, Q8C700, Q8CGI2, Q99PQ4	Gene names	Trim8, Gerp, Rnf27
Domain Architecture
Description	Tripartite motif-containing protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein).

ZN179_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.088673 (rank : 117)
Query Neighborhood Hits	142	Target Neighborhood Hits	178	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ULX5, O60633	Gene names	ZNF179, BFP, RNF112
Domain Architecture
Description	Zinc finger protein 179 (Brain finger protein) (RING finger protein 112).

Hits sorted by NC score

BIRC2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	142	Target Neighborhood Hits	142	Shared Neighborhood Hits	142
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

BIRC2_MOUSE
NC score	0.996181 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	142	Target Neighborhood Hits	137	Shared Neighborhood Hits	121
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

BIRC3_HUMAN
NC score	0.992665 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	142	Target Neighborhood Hits	133	Shared Neighborhood Hits	116
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).

BIRC3_MOUSE
NC score	0.988354 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	142	Target Neighborhood Hits	113	Shared Neighborhood Hits	99
SwissProt Accessions	O08863	Gene names	Birc3, Birc2, Iap1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (MIAP1) (MIAP-1).

BIRC4_HUMAN
NC score	0.927059 (rank : 5)	θ value	1.00591e-75 (rank : 5)
Query Neighborhood Hits	142	Target Neighborhood Hits	89	Shared Neighborhood Hits	78
SwissProt Accessions	P98170, Q9NQ14	Gene names	BIRC4, API3, IAP3, XIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP).

BIRC4_MOUSE
NC score	0.926047 (rank : 6)	θ value	1.11217e-74 (rank : 6)
Query Neighborhood Hits	142	Target Neighborhood Hits	89	Shared Neighborhood Hits	78
SwissProt Accessions	Q60989, O08865	Gene names	Birc4, Aipa, Api3, Miha, Xiap
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3).

BIRC8_HUMAN
NC score	0.870041 (rank : 7)	θ value	1.12775e-26 (rank : 13)
Query Neighborhood Hits	142	Target Neighborhood Hits	121	Shared Neighborhood Hits	95
SwissProt Accessions	Q96P09, Q96RW5	Gene names	BIRC8, ILP2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis- like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis).

BIRC7_HUMAN
NC score	0.844941 (rank : 8)	θ value	1.37858e-24 (rank : 14)
Query Neighborhood Hits	142	Target Neighborhood Hits	185	Shared Neighborhood Hits	113
SwissProt Accessions	Q96CA5, Q9BQV0, Q9H2A8, Q9HAP7	Gene names	BIRC7, KIAP, LIVIN, MLIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 7 (Kidney inhibitor of apoptosis protein) (KIAP) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (Livin).

BIRC1_HUMAN
NC score	0.713640 (rank : 9)	θ value	5.76516e-39 (rank : 10)
Query Neighborhood Hits	142	Target Neighborhood Hits	61	Shared Neighborhood Hits	20
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

BIR1E_MOUSE
NC score	0.711231 (rank : 10)	θ value	7.27602e-42 (rank : 7)
Query Neighborhood Hits	142	Target Neighborhood Hits	93	Shared Neighborhood Hits	19
SwissProt Accessions	Q9R016, O09121, O09122, P81703, Q9R029	Gene names	Birc1e, Naip-rs3, Naip5
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1e (Neuronal apoptosis inhibitory protein 5).

BIR1B_MOUSE
NC score	0.710989 (rank : 11)	θ value	9.83387e-39 (rank : 11)
Query Neighborhood Hits	142	Target Neighborhood Hits	93	Shared Neighborhood Hits	20
SwissProt Accessions	Q9QUK4, O09124, Q9R030	Gene names	Birc1b, Naip-rs6, Naip2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1b (Neuronal apoptosis inhibitory protein 2).

BIR1F_MOUSE
NC score	0.710564 (rank : 12)	θ value	9.50281e-42 (rank : 8)
Query Neighborhood Hits	142	Target Neighborhood Hits	88	Shared Neighborhood Hits	20
SwissProt Accessions	Q9JIB6, O09121, O09122, P81704	Gene names	Birc1f, Naip-rs4, Naip6
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1f (Neuronal apoptosis inhibitory protein 6).

BIR1G_MOUSE
NC score	0.710519 (rank : 13)	θ value	1.62093e-41 (rank : 9)
Query Neighborhood Hits	142	Target Neighborhood Hits	92	Shared Neighborhood Hits	20
SwissProt Accessions	Q9JIB3	Gene names	Birc1g, Naip7
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1g (Neuronal apoptosis inhibitory protein 7).

BIR1A_MOUSE
NC score	0.704498 (rank : 14)	θ value	4.88048e-38 (rank : 12)
Query Neighborhood Hits	142	Target Neighborhood Hits	94	Shared Neighborhood Hits	19
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

BIRC5_MOUSE
NC score	0.625038 (rank : 15)	θ value	2.61198e-07 (rank : 24)
Query Neighborhood Hits	142	Target Neighborhood Hits	19	Shared Neighborhood Hits	17
SwissProt Accessions	O70201, Q923F7, Q9WU53, Q9WU54	Gene names	Birc5, Api4, Iap4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4) (TIAP).

BIRC5_HUMAN
NC score	0.605749 (rank : 16)	θ value	1.29631e-06 (rank : 27)
Query Neighborhood Hits	142	Target Neighborhood Hits	20	Shared Neighborhood Hits	18
SwissProt Accessions	O15392, Q2I3N8, Q4VGX0, Q53F61, Q5MGC6, Q6FHL2, Q75SP2, Q9P2W8	Gene names	BIRC5, API4, IAP4
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor survivin) (Apoptosis inhibitor 4).

RFFL_MOUSE
NC score	0.469263 (rank : 17)	θ value	4.76016e-09 (rank : 18)
Query Neighborhood Hits	142	Target Neighborhood Hits	145	Shared Neighborhood Hits	74
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RNF34_MOUSE
NC score	0.465226 (rank : 18)	θ value	5.26297e-08 (rank : 20)
Query Neighborhood Hits	142	Target Neighborhood Hits	160	Shared Neighborhood Hits	82
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

RNF34_HUMAN
NC score	0.464235 (rank : 19)	θ value	5.26297e-08 (rank : 19)
Query Neighborhood Hits	142	Target Neighborhood Hits	153	Shared Neighborhood Hits	81
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

RFFL_HUMAN
NC score	0.462711 (rank : 20)	θ value	4.76016e-09 (rank : 17)
Query Neighborhood Hits	142	Target Neighborhood Hits	175	Shared Neighborhood Hits	74
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

RNF26_HUMAN
NC score	0.452178 (rank : 21)	θ value	4.92598e-06 (rank : 29)
Query Neighborhood Hits	142	Target Neighborhood Hits	95	Shared Neighborhood Hits	60
SwissProt Accessions	Q9BY78	Gene names	RNF26
Domain Architecture	No domain graphic available
Description	RING finger protein 26.

CAR12_HUMAN
NC score	0.391022 (rank : 22)	θ value	0.000158464 (rank : 32)
Query Neighborhood Hits	142	Target Neighborhood Hits	132	Shared Neighborhood Hits	14
SwissProt Accessions	Q9NPP4, Q96J81, Q96J82, Q96J83	Gene names	CARD12, CLAN, CLAN1
Domain Architecture
Description	Caspase recruitment domain-containing protein 12 (Ice protease- activating factor) (Ipaf) (CARD, LRR, and NACHT-containing protein) (Clan protein).

BIRC6_HUMAN
NC score	0.380637 (rank : 23)	θ value	9.59137e-10 (rank : 16)
Query Neighborhood Hits	142	Target Neighborhood Hits	161	Shared Neighborhood Hits	17
SwissProt Accessions	Q9NR09, Q9ULD1	Gene names	BIRC6, KIAA1289
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 6 (Ubiquitin-conjugating BIR-domain enzyme apollon).

RKHD1_HUMAN
NC score	0.348222 (rank : 24)	θ value	0.00175202 (rank : 39)
Query Neighborhood Hits	142	Target Neighborhood Hits	163	Shared Neighborhood Hits	65
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

CGRF1_HUMAN
NC score	0.332593 (rank : 25)	θ value	0.00035302 (rank : 34)
Query Neighborhood Hits	142	Target Neighborhood Hits	51	Shared Neighborhood Hits	38
SwissProt Accessions	Q99675, Q96BX2	Gene names	CGRRF1, CGR19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

CGRF1_MOUSE
NC score	0.330223 (rank : 26)	θ value	0.000461057 (rank : 35)
Query Neighborhood Hits	142	Target Neighborhood Hits	47	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BMJ7, Q3U3F1, Q8CI24	Gene names	Cgrrf1, Cgr19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

NEURL_MOUSE
NC score	0.327355 (rank : 27)	θ value	7.1131e-05 (rank : 30)
Query Neighborhood Hits	142	Target Neighborhood Hits	106	Shared Neighborhood Hits	68
SwissProt Accessions	Q923S6, Q91ZT6, Q9CWF1, Q9QWF1	Gene names	Neurl, Neurl1
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (m-neuralized 1) (m-neu1).

NEUL1_HUMAN
NC score	0.322007 (rank : 28)	θ value	9.29e-05 (rank : 31)
Query Neighborhood Hits	142	Target Neighborhood Hits	114	Shared Neighborhood Hits	69
SwissProt Accessions	O76050, Q5TDR2, Q5TDR3, Q8TAN0, Q9H463	Gene names	NEURL, NEURL1, RNF67
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (h-neuralized 1) (h-neu) (RING finger protein 67).

MYLIP_HUMAN
NC score	0.295955 (rank : 29)	θ value	5.08577e-11 (rank : 15)
Query Neighborhood Hits	142	Target Neighborhood Hits	162	Shared Neighborhood Hits	75
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

MGRN1_MOUSE
NC score	0.263755 (rank : 30)	θ value	0.00509761 (rank : 45)
Query Neighborhood Hits	142	Target Neighborhood Hits	149	Shared Neighborhood Hits	74
SwissProt Accessions	Q9D074, Q3U5V9, Q3UDA1, Q6ZQ97, Q8BZM9	Gene names	Mgrn1, Kiaa0544
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1).

MGRN1_HUMAN
NC score	0.257502 (rank : 31)	θ value	0.00509761 (rank : 44)
Query Neighborhood Hits	142	Target Neighborhood Hits	192	Shared Neighborhood Hits	74
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

MYLIP_MOUSE
NC score	0.252038 (rank : 32)	θ value	4.45536e-07 (rank : 26)
Query Neighborhood Hits	142	Target Neighborhood Hits	139	Shared Neighborhood Hits	57
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

LRSM1_MOUSE
NC score	0.211584 (rank : 33)	θ value	1.17247e-07 (rank : 22)
Query Neighborhood Hits	142	Target Neighborhood Hits	874	Shared Neighborhood Hits	74
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

CBLC_MOUSE
NC score	0.201753 (rank : 34)	θ value	0.0330416 (rank : 51)
Query Neighborhood Hits	142	Target Neighborhood Hits	186	Shared Neighborhood Hits	74
SwissProt Accessions	Q80XL1, Q99PB6, Q9D6L2, Q9D7A9	Gene names	Cblc, Cbl3
Domain Architecture	No domain graphic available
Description	Signal transduction protein CBL-C (SH3-binding protein CBL-C) (CBL-3).

CBL_HUMAN
NC score	0.200449 (rank : 35)	θ value	0.00228821 (rank : 40)
Query Neighborhood Hits	142	Target Neighborhood Hits	353	Shared Neighborhood Hits	82
SwissProt Accessions	P22681	Gene names	CBL, CBL2, RNF55
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene) (RING finger protein 55).

CBLB_MOUSE
NC score	0.198277 (rank : 36)	θ value	0.00509761 (rank : 43)
Query Neighborhood Hits	142	Target Neighborhood Hits	277	Shared Neighborhood Hits	84
SwissProt Accessions	Q3TTA7	Gene names	Cblb
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b).

CBLB_HUMAN
NC score	0.197962 (rank : 37)	θ value	0.00509761 (rank : 42)
Query Neighborhood Hits	142	Target Neighborhood Hits	261	Shared Neighborhood Hits	84
SwissProt Accessions	Q13191, Q13192, Q13193, Q3LIC0, Q8IVC5	Gene names	CBLB, RNF56
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56).

CBL_MOUSE
NC score	0.195939 (rank : 38)	θ value	0.00228821 (rank : 41)
Query Neighborhood Hits	142	Target Neighborhood Hits	426	Shared Neighborhood Hits	84
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

LRSM1_HUMAN
NC score	0.187788 (rank : 39)	θ value	2.61198e-07 (rank : 25)
Query Neighborhood Hits	142	Target Neighborhood Hits	1078	Shared Neighborhood Hits	77
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

CBLC_HUMAN
NC score	0.186819 (rank : 40)	θ value	0.125558 (rank : 55)
Query Neighborhood Hits	142	Target Neighborhood Hits	173	Shared Neighborhood Hits	75
SwissProt Accessions	Q9ULV8, Q8N1E5, Q9Y5Z2, Q9Y5Z3	Gene names	CBLC, CBL3, RNF57
Domain Architecture
Description	Signal transduction protein CBL-C (SH3-binding protein CBL-C) (CBL-3) (RING finger protein 57).

PEX10_HUMAN
NC score	0.183138 (rank : 41)	θ value	0.125558 (rank : 56)
Query Neighborhood Hits	142	Target Neighborhood Hits	255	Shared Neighborhood Hits	90
SwissProt Accessions	O60683, Q5T095, Q9BW90	Gene names	PEX10, RNF69
Domain Architecture
Description	Peroxisome assembly protein 10 (Peroxin-10) (Peroxisome biogenesis factor 10) (RING finger protein 69).

MDM4_HUMAN
NC score	0.182622 (rank : 42)	θ value	0.00869519 (rank : 46)
Query Neighborhood Hits	142	Target Neighborhood Hits	37	Shared Neighborhood Hits	24
SwissProt Accessions	O15151, Q6GS18, Q8IV83	Gene names	MDM4, MDMX
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

TRI26_MOUSE
NC score	0.182299 (rank : 43)	θ value	0.000602161 (rank : 37)
Query Neighborhood Hits	142	Target Neighborhood Hits	339	Shared Neighborhood Hits	103
SwissProt Accessions	Q99PN3, Q8C9E9, Q8JZT7, Q99PN2	Gene names	Trim26, Znf173
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173).

TRI26_HUMAN
NC score	0.178890 (rank : 44)	θ value	0.00134147 (rank : 38)
Query Neighborhood Hits	142	Target Neighborhood Hits	335	Shared Neighborhood Hits	100
SwissProt Accessions	Q12899	Gene names	TRIM26, RNF95, ZNF173
Domain Architecture
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173) (Acid finger protein) (AFP) (RING finger protein 95).

MIB1_MOUSE
NC score	0.175636 (rank : 45)	θ value	8.97725e-08 (rank : 21)
Query Neighborhood Hits	142	Target Neighborhood Hits	471	Shared Neighborhood Hits	89
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

MIB1_HUMAN
NC score	0.174140 (rank : 46)	θ value	1.17247e-07 (rank : 23)
Query Neighborhood Hits	142	Target Neighborhood Hits	470	Shared Neighborhood Hits	89
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

MIB2_HUMAN
NC score	0.167255 (rank : 47)	θ value	4.92598e-06 (rank : 28)
Query Neighborhood Hits	142	Target Neighborhood Hits	438	Shared Neighborhood Hits	70
SwissProt Accessions	Q96AX9, Q7Z437, Q8IY62, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1	Gene names	MIB2, SKD, ZZANK1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Zinc finger ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) (Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating protein 002N).

MIB2_MOUSE
NC score	0.159548 (rank : 48)	θ value	0.000158464 (rank : 33)
Query Neighborhood Hits	142	Target Neighborhood Hits	409	Shared Neighborhood Hits	68
SwissProt Accessions	Q8R516, Q52QU8, Q6PEF6, Q8C1N7, Q8VIB4	Gene names	Mib2, Skd
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin) (Dystrophin-like protein) (Dyslike).

TRI31_HUMAN
NC score	0.156921 (rank : 49)	θ value	0.125558 (rank : 61)
Query Neighborhood Hits	142	Target Neighborhood Hits	299	Shared Neighborhood Hits	90
SwissProt Accessions	Q9BZY9, Q53H52, Q5RI37, Q5SRJ7, Q5SRJ8, Q5SS28, Q96AK4, Q96AP8, Q99579, Q9BZY8	Gene names	TRIM31, C6orf13, RNF
Domain Architecture
Description	Tripartite motif-containing protein 31.

SIAH2_MOUSE
NC score	0.153189 (rank : 50)	θ value	0.163984 (rank : 66)
Query Neighborhood Hits	142	Target Neighborhood Hits	101	Shared Neighborhood Hits	43
SwissProt Accessions	Q06986	Gene names	Siah2
Domain Architecture
Description	Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (mSiah2).

MDM2_HUMAN
NC score	0.152249 (rank : 51)	θ value	0.365318 (rank : 69)
Query Neighborhood Hits	142	Target Neighborhood Hits	92	Shared Neighborhood Hits	26
SwissProt Accessions	Q00987, Q13226, Q13297, Q13298, Q13299, Q13300, Q13301, Q53XW0, Q71TW9, Q9UGI3, Q9UMT8	Gene names	MDM2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2).

SIAH2_HUMAN
NC score	0.152243 (rank : 52)	θ value	0.163984 (rank : 65)
Query Neighborhood Hits	142	Target Neighborhood Hits	94	Shared Neighborhood Hits	43
SwissProt Accessions	O43255, O43270	Gene names	SIAH2
Domain Architecture
Description	Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (hSiah2).

RO52_HUMAN
NC score	0.151577 (rank : 53)	θ value	0.000602161 (rank : 36)
Query Neighborhood Hits	142	Target Neighborhood Hits	419	Shared Neighborhood Hits	101
SwissProt Accessions	P19474, Q96RF8	Gene names	TRIM21, RNF81, RO52, SSA1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21) (RING finger protein 81).

RN185_HUMAN
NC score	0.146678 (rank : 54)	θ value	3.0926 (rank : 104)
Query Neighborhood Hits	142	Target Neighborhood Hits	213	Shared Neighborhood Hits	88
SwissProt Accessions	Q96GF1, Q8N900	Gene names	RNF185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

RN185_MOUSE
NC score	0.145509 (rank : 55)	θ value	3.0926 (rank : 105)
Query Neighborhood Hits	142	Target Neighborhood Hits	211	Shared Neighborhood Hits	88
SwissProt Accessions	Q91YT2, Q6ZWS3	Gene names	Rnf185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

RO52_MOUSE
NC score	0.144872 (rank : 56)	θ value	0.00869519 (rank : 47)
Query Neighborhood Hits	142	Target Neighborhood Hits	360	Shared Neighborhood Hits	94
SwissProt Accessions	Q62191	Gene names	Trim21, Ro52, Ssa1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21).

SIA1B_MOUSE
NC score	0.139786 (rank : 57)	θ value	0.163984 (rank : 63)
Query Neighborhood Hits	142	Target Neighborhood Hits	69	Shared Neighborhood Hits	32
SwissProt Accessions	Q06985, Q7TPV6	Gene names	Siah1b
Domain Architecture
Description	Ubiquitin ligase SIAH1B (EC 6.3.2.-) (Seven in absentia homolog 1b) (Siah1b) (Siah-1b).

RN168_HUMAN
NC score	0.139668 (rank : 58)	θ value	1.81305 (rank : 93)
Query Neighborhood Hits	142	Target Neighborhood Hits	370	Shared Neighborhood Hits	93
SwissProt Accessions	Q8IYW5, Q8NA67, Q96NS4	Gene names	RNF168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

SIA1A_MOUSE
NC score	0.138302 (rank : 59)	θ value	0.163984 (rank : 62)
Query Neighborhood Hits	142	Target Neighborhood Hits	72	Shared Neighborhood Hits	32
SwissProt Accessions	P61092, Q06984	Gene names	Siah1a
Domain Architecture
Description	Ubiquitin ligase SIAH1A (EC 6.3.2.-) (Seven in absentia homolog 1a) (Siah1a) (Siah-1a) (mSiah-1a).

SIAH1_HUMAN
NC score	0.138262 (rank : 60)	θ value	0.163984 (rank : 64)
Query Neighborhood Hits	142	Target Neighborhood Hits	72	Shared Neighborhood Hits	32
SwissProt Accessions	Q8IUQ4, O43269, Q92880	Gene names	SIAH1, HUMSIAH
Domain Architecture
Description	Ubiquitin ligase SIAH1 (EC 6.3.2.-) (Seven in absentia homolog 1) (Siah-1) (Siah-1a).

TRI52_HUMAN
NC score	0.137299 (rank : 61)	θ value	1.81305 (rank : 94)
Query Neighborhood Hits	142	Target Neighborhood Hits	213	Shared Neighborhood Hits	76
SwissProt Accessions	Q96A61	Gene names	TRIM52, RNF102
Domain Architecture
Description	Tripartite motif-containing protein 52 (RING finger protein 102).

TRI12_MOUSE
NC score	0.133928 (rank : 62)	θ value	0.125558 (rank : 59)
Query Neighborhood Hits	142	Target Neighborhood Hits	387	Shared Neighborhood Hits	89
SwissProt Accessions	Q99PQ1, Q9D704	Gene names	Trim12
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 12.

TRI50_MOUSE
NC score	0.130869 (rank : 63)	θ value	0.813845 (rank : 83)
Query Neighborhood Hits	142	Target Neighborhood Hits	326	Shared Neighborhood Hits	103
SwissProt Accessions	Q810I2	Gene names	Trim50
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 50.

ZN313_MOUSE
NC score	0.130769 (rank : 64)	θ value	0.47712 (rank : 74)
Query Neighborhood Hits	142	Target Neighborhood Hits	273	Shared Neighborhood Hits	89
SwissProt Accessions	Q9ET26, Q3UFU8, Q8K5A2	Gene names	Znf313, Zfp228, Zfp313, Znf228
Domain Architecture
Description	Zinc finger protein 313.

TRI73_HUMAN
NC score	0.129904 (rank : 65)	θ value	1.81305 (rank : 95)
Query Neighborhood Hits	142	Target Neighborhood Hits	258	Shared Neighborhood Hits	94
SwissProt Accessions	Q86UV7, Q8N0S3	Gene names	TRIM73, TRIM50B
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 73 (Tripartite motif-containing protein 50B).

MDM2_MOUSE
NC score	0.129310 (rank : 66)	θ value	1.38821 (rank : 90)
Query Neighborhood Hits	142	Target Neighborhood Hits	77	Shared Neighborhood Hits	27
SwissProt Accessions	P23804, Q61040, Q64330	Gene names	Mdm2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein).

TRI17_MOUSE
NC score	0.127981 (rank : 67)	θ value	0.0113563 (rank : 48)
Query Neighborhood Hits	142	Target Neighborhood Hits	620	Shared Neighborhood Hits	87
SwissProt Accessions	Q7TPM3, Q99PP8	Gene names	Trim17
Domain Architecture
Description	Tripartite motif-containing protein 17.

ZN313_HUMAN
NC score	0.127958 (rank : 68)	θ value	0.365318 (rank : 70)
Query Neighborhood Hits	142	Target Neighborhood Hits	264	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Y508, Q6N0B0	Gene names	ZNF313, RNF114, ZNF228
Domain Architecture
Description	Zinc finger protein 313 (RING finger protein 114).

TRI17_HUMAN
NC score	0.126669 (rank : 69)	θ value	0.125558 (rank : 60)
Query Neighborhood Hits	142	Target Neighborhood Hits	318	Shared Neighborhood Hits	90
SwissProt Accessions	Q9Y577	Gene names	TRIM17, RBCC, RNF16, TERF
Domain Architecture
Description	Tripartite motif-containing protein 17 (Testis RING finger protein) (RING finger protein 16).

TRI50_HUMAN
NC score	0.124167 (rank : 70)	θ value	0.813845 (rank : 82)
Query Neighborhood Hits	142	Target Neighborhood Hits	294	Shared Neighborhood Hits	99
SwissProt Accessions	Q86XT4, Q86XT3	Gene names	TRIM50, TRIM50A
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 50.

TRI27_MOUSE
NC score	0.124138 (rank : 71)	θ value	0.21417 (rank : 68)
Query Neighborhood Hits	142	Target Neighborhood Hits	261	Shared Neighborhood Hits	96
SwissProt Accessions	Q62158, Q62157, Q8C2Q5, Q99LK1	Gene names	Trim27, Rfp
Domain Architecture
Description	Zinc finger protein RFP (Ret finger protein) (Tripartite motif- containing protein 27).

TRI11_MOUSE
NC score	0.123110 (rank : 72)	θ value	0.125558 (rank : 58)
Query Neighborhood Hits	142	Target Neighborhood Hits	329	Shared Neighborhood Hits	94
SwissProt Accessions	Q99PQ2, Q8VDX5	Gene names	Trim11
Domain Architecture
Description	Tripartite motif-containing protein 11 (EC 6.3.2.-).

TRI35_MOUSE
NC score	0.122216 (rank : 73)	θ value	4.03905 (rank : 116)
Query Neighborhood Hits	142	Target Neighborhood Hits	465	Shared Neighborhood Hits	95
SwissProt Accessions	Q8C006, Q6ZPY0, Q7TQL7, Q810V7, Q8BVY9, Q8VID4, Q9CW74, Q9D208	Gene names	Trim35, Hls5, Kiaa1098, Mair
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 35 (Macrophage-derived apoptosis- inducing RBCC protein) (Protein MAIR) (Protein Nc8) (Hemopoietic lineage switch protein 5).

TRI11_HUMAN
NC score	0.121593 (rank : 74)	θ value	0.125558 (rank : 57)
Query Neighborhood Hits	142	Target Neighborhood Hits	316	Shared Neighborhood Hits	94
SwissProt Accessions	Q96F44, Q8NCA6, Q9C022	Gene names	TRIM11, RNF92
Domain Architecture
Description	Tripartite motif-containing protein 11 (EC 6.3.2.-) (RING finger protein 92) (Protein BIA1).

RNF5_HUMAN
NC score	0.121171 (rank : 75)	θ value	6.88961 (rank : 133)
Query Neighborhood Hits	142	Target Neighborhood Hits	206	Shared Neighborhood Hits	87
SwissProt Accessions	Q99942, Q9UMQ2	Gene names	RNF5, G16, NG2, RMA1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (HsRma1) (RING finger protein 5) (Protein G16).

TRI43_HUMAN
NC score	0.120922 (rank : 76)	θ value	0.47712 (rank : 72)
Query Neighborhood Hits	142	Target Neighborhood Hits	341	Shared Neighborhood Hits	90
SwissProt Accessions	Q96BQ3	Gene names	TRIM43
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 43.

RNF5_MOUSE
NC score	0.120136 (rank : 77)	θ value	6.88961 (rank : 134)
Query Neighborhood Hits	142	Target Neighborhood Hits	206	Shared Neighborhood Hits	87
SwissProt Accessions	O35445	Gene names	Rnf5, Ng2
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (RING finger protein 5).

TRI60_HUMAN
NC score	0.120025 (rank : 78)	θ value	0.47712 (rank : 73)
Query Neighborhood Hits	142	Target Neighborhood Hits	357	Shared Neighborhood Hits	98
SwissProt Accessions	Q495X7, Q8NA35	Gene names	TRIM60, RNF129
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 60 (RING finger protein 129).

LRC31_HUMAN
NC score	0.119042 (rank : 79)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	142	Target Neighborhood Hits	139	Shared Neighborhood Hits	8
SwissProt Accessions	Q6UY01, Q8N848, Q9H5N5	Gene names	LRRC31
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 31.

TRI74_HUMAN
NC score	0.118692 (rank : 80)	θ value	4.03905 (rank : 120)
Query Neighborhood Hits	142	Target Neighborhood Hits	249	Shared Neighborhood Hits	91
SwissProt Accessions	Q86UV6	Gene names	TRIM74, TRIM50C
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 74 (Tripartite motif-containing protein 50C).

TRI40_HUMAN
NC score	0.115655 (rank : 81)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	142	Target Neighborhood Hits	279	Shared Neighborhood Hits	86
SwissProt Accessions	Q6P9F5, Q8TD96	Gene names	TRIM40, RNF35
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 40 (RING finger protein 35).

TRI27_HUMAN
NC score	0.115553 (rank : 82)	θ value	0.813845 (rank : 81)
Query Neighborhood Hits	142	Target Neighborhood Hits	273	Shared Neighborhood Hits	94
SwissProt Accessions	P14373, Q5ST26, Q6LA73, Q6NXR9, Q9BZY6, Q9UJL3	Gene names	TRIM27, RFP, RNF76
Domain Architecture
Description	Zinc finger protein RFP (Ret finger protein) (Tripartite motif- containing protein 27) (RING finger protein 76).

TRIM4_HUMAN
NC score	0.115324 (rank : 83)	θ value	2.36792 (rank : 101)
Query Neighborhood Hits	142	Target Neighborhood Hits	321	Shared Neighborhood Hits	93
SwissProt Accessions	Q9C037, Q96F06, Q9C036	Gene names	TRIM4, RNF87
Domain Architecture
Description	Tripartite motif-containing protein 4 (RING finger protein 87).

TRIM5_HUMAN
NC score	0.113771 (rank : 84)	θ value	0.62314 (rank : 76)
Query Neighborhood Hits	142	Target Neighborhood Hits	424	Shared Neighborhood Hits	91
SwissProt Accessions	Q9C035, Q8WU46, Q96SR5, Q9C031, Q9C032, Q9C033, Q9C034	Gene names	TRIM5, RNF88
Domain Architecture
Description	Tripartite motif-containing protein 5 (EC 6.3.2.-) (RING finger protein 88).

TRI35_HUMAN
NC score	0.113446 (rank : 85)	θ value	8.99809 (rank : 141)
Query Neighborhood Hits	142	Target Neighborhood Hits	382	Shared Neighborhood Hits	94
SwissProt Accessions	Q9UPQ4, Q86XQ0, Q8WVA4	Gene names	TRIM35, HLS5, KIAA1098
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 35 (Hemopoietic lineage switch protein 5).

RNF8_HUMAN
NC score	0.112417 (rank : 86)	θ value	5.27518 (rank : 122)
Query Neighborhood Hits	142	Target Neighborhood Hits	622	Shared Neighborhood Hits	102
SwissProt Accessions	O76064	Gene names	RNF8, KIAA0646
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8).

TRI68_MOUSE
NC score	0.111174 (rank : 87)	θ value	1.06291 (rank : 89)
Query Neighborhood Hits	142	Target Neighborhood Hits	356	Shared Neighborhood Hits	89
SwissProt Accessions	Q8K243	Gene names	Trim68, Rnf137
Domain Architecture	No domain graphic available
Description	Tripartite motif containing protein 68 (Ring finger protein 137).

TRI15_HUMAN
NC score	0.110911 (rank : 88)	θ value	2.36792 (rank : 99)
Query Neighborhood Hits	142	Target Neighborhood Hits	395	Shared Neighborhood Hits	80
SwissProt Accessions	Q9C019, O95604, Q8IUX9, Q9C018	Gene names	TRIM15, RNF93, ZNF178, ZNFB7
Domain Architecture
Description	Tripartite motif-containing protein 15 (Zinc finger protein B7) (RING finger protein 93) (Zinc finger protein 178).

TRI39_HUMAN
NC score	0.110640 (rank : 89)	θ value	3.0926 (rank : 107)
Query Neighborhood Hits	142	Target Neighborhood Hits	693	Shared Neighborhood Hits	94
SwissProt Accessions	Q9HCM9, Q76BL3, Q8IYT9, Q96IB6	Gene names	TRIM39, RNF23, TFP
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

TRI39_MOUSE
NC score	0.110396 (rank : 90)	θ value	3.0926 (rank : 108)
Query Neighborhood Hits	142	Target Neighborhood Hits	691	Shared Neighborhood Hits	93
SwissProt Accessions	Q9ESN2, Q8BPR5, Q8K0F7	Gene names	Trim39, Rnf23, Tfp
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

TRI65_MOUSE
NC score	0.109409 (rank : 91)	θ value	6.88961 (rank : 136)
Query Neighborhood Hits	142	Target Neighborhood Hits	340	Shared Neighborhood Hits	94
SwissProt Accessions	Q8BFW4, Q6PGD3	Gene names	Trim65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

RNF8_MOUSE
NC score	0.109301 (rank : 92)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	142	Target Neighborhood Hits	618	Shared Neighborhood Hits	103
SwissProt Accessions	Q8VC56, Q9JK13	Gene names	Rnf8
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8) (AIP37) (ActA-interacting protein 37) (LaXp180).

TRI65_HUMAN
NC score	0.108082 (rank : 93)	θ value	4.03905 (rank : 119)
Query Neighborhood Hits	142	Target Neighborhood Hits	330	Shared Neighborhood Hits	86
SwissProt Accessions	Q6PJ69, Q4G0F0, Q6DKJ6, Q9BRP6	Gene names	TRIM65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

TRI34_MOUSE
NC score	0.107403 (rank : 94)	θ value	0.47712 (rank : 71)
Query Neighborhood Hits	142	Target Neighborhood Hits	332	Shared Neighborhood Hits	72
SwissProt Accessions	Q99PP6, Q99PP4, Q99PP5	Gene names	Trim34
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 34.

RN168_MOUSE
NC score	0.106073 (rank : 95)	θ value	5.27518 (rank : 121)
Query Neighborhood Hits	142	Target Neighborhood Hits	440	Shared Neighborhood Hits	90
SwissProt Accessions	Q80XJ2	Gene names	Rnf168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

TRI34_HUMAN
NC score	0.106009 (rank : 96)	θ value	2.36792 (rank : 100)
Query Neighborhood Hits	142	Target Neighborhood Hits	416	Shared Neighborhood Hits	80
SwissProt Accessions	Q9BYJ4, Q9C016, Q9HCR0, Q9HCR1, Q9HCR2	Gene names	TRIM34, IFP1, RNF21
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 34 (Interferon-responsive finger protein 1) (RING finger protein 21).

RN123_MOUSE
NC score	0.105640 (rank : 97)	θ value	4.03905 (rank : 112)
Query Neighborhood Hits	142	Target Neighborhood Hits	174	Shared Neighborhood Hits	71
SwissProt Accessions	Q5XPI3, Q6PGE0	Gene names	Rnf123, Kpc1
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase subunit KPC1 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123).

TRI41_HUMAN
NC score	0.105076 (rank : 98)	θ value	4.03905 (rank : 117)
Query Neighborhood Hits	142	Target Neighborhood Hits	349	Shared Neighborhood Hits	73
SwissProt Accessions	Q8WV44, Q5BKT0, Q7L484, Q96Q10, Q9BSL8	Gene names	TRIM41
Domain Architecture
Description	Tripartite motif-containing protein 41.

TRI48_HUMAN
NC score	0.104928 (rank : 99)	θ value	5.27518 (rank : 126)
Query Neighborhood Hits	142	Target Neighborhood Hits	192	Shared Neighborhood Hits	70
SwissProt Accessions	Q8IWZ4, Q9BUW4	Gene names	TRIM48, RNF101
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 48 (RING finger protein 101).

TRIM6_HUMAN
NC score	0.103087 (rank : 100)	θ value	1.81305 (rank : 96)
Query Neighborhood Hits	142	Target Neighborhood Hits	412	Shared Neighborhood Hits	79
SwissProt Accessions	Q9C030, Q86WZ8, Q9HCR1	Gene names	TRIM6, RNF89
Domain Architecture
Description	Tripartite motif-containing protein 6 (RING finger protein 89).

RN123_HUMAN
NC score	0.102292 (rank : 101)	θ value	4.03905 (rank : 111)
Query Neighborhood Hits	142	Target Neighborhood Hits	175	Shared Neighborhood Hits	69
SwissProt Accessions	Q5XPI4, Q5I022, Q6PFW4, Q71RH0, Q8IW18, Q9H0M8, Q9H5L8, Q9H9T2	Gene names	RNF123, KPC1
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase subunit KPC1 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123).

TRI25_MOUSE
NC score	0.102093 (rank : 102)	θ value	1.38821 (rank : 91)
Query Neighborhood Hits	142	Target Neighborhood Hits	446	Shared Neighborhood Hits	90
SwissProt Accessions	Q61510	Gene names	Trim25, Efp, Zfp147, Znf147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp).

TRI30_MOUSE
NC score	0.101798 (rank : 103)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	142	Target Neighborhood Hits	434	Shared Neighborhood Hits	83
SwissProt Accessions	P15533, Q99K55, Q99PQ7, Q99PQ8, Q99PQ9	Gene names	Trim30, Rpt-1, Rpt1
Domain Architecture
Description	Tripartite motif-containing protein 30 (Down regulatory protein of interleukin 2 receptor).

TRIM6_MOUSE
NC score	0.098693 (rank : 104)	θ value	8.99809 (rank : 142)
Query Neighborhood Hits	142	Target Neighborhood Hits	451	Shared Neighborhood Hits	75
SwissProt Accessions	Q8BGE7, Q99PQ6	Gene names	Trim6
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 6.

TRI22_HUMAN
NC score	0.098401 (rank : 105)	θ value	8.99809 (rank : 140)
Query Neighborhood Hits	142	Target Neighborhood Hits	396	Shared Neighborhood Hits	78
SwissProt Accessions	Q8IYM9, Q15521	Gene names	TRIM22, RNF94, STAF50
Domain Architecture
Description	Tripartite motif-containing protein 22 (RING finger protein 94) (50 kDa-stimulated trans-acting factor) (Staf-50).

TRI38_HUMAN
NC score	0.097131 (rank : 106)	θ value	3.0926 (rank : 106)
Query Neighborhood Hits	142	Target Neighborhood Hits	373	Shared Neighborhood Hits	75
SwissProt Accessions	O00635	Gene names	TRIM38, RNF15, RORET
Domain Architecture
Description	Tripartite motif-containing protein 38 (RING finger protein 15) (Zinc finger protein RoRet).

MDM4_MOUSE
NC score	0.096904 (rank : 107)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	142	Target Neighborhood Hits	36	Shared Neighborhood Hits	16
SwissProt Accessions	O35618	Gene names	Mdm4, Mdmx
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

TRI68_HUMAN
NC score	0.096395 (rank : 108)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	142	Target Neighborhood Hits	267	Shared Neighborhood Hits	79
SwissProt Accessions	Q6AZZ1, Q8WZ70, Q96PF7, Q9H9C2, Q9NW18	Gene names	TRIM68, RNF137, SS56
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 68 (RING finger protein 137) (SSA protein SS-56) (SS-56).

TRI10_HUMAN
NC score	0.093493 (rank : 109)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	142	Target Neighborhood Hits	315	Shared Neighborhood Hits	80
SwissProt Accessions	Q9UDY6, Q86Z08, Q96QB6, Q9C023, Q9C024	Gene names	TRIM10, RFB30, RNF9
Domain Architecture
Description	Tripartite motif-containing protein 10 (RING finger protein 9) (B30- RING finger protein).

TRI60_MOUSE
NC score	0.091680 (rank : 110)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	142	Target Neighborhood Hits	240	Shared Neighborhood Hits	76
SwissProt Accessions	Q8VI40, Q3UX74	Gene names	Trim60, 2czf45, Rnf33
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 60 (Ring finger protein 33).

RN169_HUMAN
NC score	0.091040 (rank : 111)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	142	Target Neighborhood Hits	203	Shared Neighborhood Hits	66
SwissProt Accessions	Q8NCN4, Q6N015	Gene names	RNF169, KIAA1991
Domain Architecture	No domain graphic available
Description	RING finger protein 169.

TRI10_MOUSE
NC score	0.090814 (rank : 112)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	142	Target Neighborhood Hits	285	Shared Neighborhood Hits	81
SwissProt Accessions	Q9WUH5, Q80WA9, Q9CY03	Gene names	Trim10, Herf1, Rnf9
Domain Architecture
Description	Tripartite motif-containing protein 10 (RING finger protein 9) (Hematopoietic RING finger 1).

TRI49_HUMAN
NC score	0.090053 (rank : 113)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	142	Target Neighborhood Hits	199	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NS80, Q6DJV1	Gene names	TRIM49, RNF18
Domain Architecture
Description	Tripartite motif-containing protein 49 (RING finger protein 18) (Testis-specific ring-finger protein).

RN141_HUMAN
NC score	0.089445 (rank : 114)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	142	Target Neighborhood Hits	199	Shared Neighborhood Hits	68
SwissProt Accessions	Q8WVD5, Q9NZB4	Gene names	RNF141, ZNF230
Domain Architecture	No domain graphic available
Description	RING finger protein 141 (Zinc finger protein 230).

RN141_MOUSE
NC score	0.088968 (rank : 115)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	142	Target Neighborhood Hits	200	Shared Neighborhood Hits	68
SwissProt Accessions	Q99MB7, Q9D040, Q9D5C4, Q9D9L0	Gene names	Rnf141, Znf230
Domain Architecture	No domain graphic available
Description	RING finger protein 141 (Zinc finger protein 230).

TRI56_HUMAN
NC score	0.088699 (rank : 116)	θ value	4.03905 (rank : 118)
Query Neighborhood Hits	142	Target Neighborhood Hits	339	Shared Neighborhood Hits	80
SwissProt Accessions	Q9BRZ2, Q86VT6, Q8N2H8, Q8NAC0, Q9H031	Gene names	TRIM56, RNF109
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 56 (RING finger protein 109).

ZN179_HUMAN
NC score	0.088673 (rank : 117)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	142	Target Neighborhood Hits	178	Shared Neighborhood Hits	72
SwissProt Accessions	Q9ULX5, O60633	Gene names	ZNF179, BFP, RNF112
Domain Architecture
Description	Zinc finger protein 179 (Brain finger protein) (RING finger protein 112).

TRIM7_HUMAN
NC score	0.088258 (rank : 118)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	142	Target Neighborhood Hits	336	Shared Neighborhood Hits	68
SwissProt Accessions	Q9C029, Q969F5, Q96F67, Q96J89, Q96J90	Gene names	TRIM7, GNIP, RNF90
Domain Architecture
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein) (RING finger protein 90).

CAR15_MOUSE
NC score	0.088097 (rank : 119)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	142	Target Neighborhood Hits	93	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K3Z0	Gene names	Card15, Nod2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2).

TRIM7_MOUSE
NC score	0.088008 (rank : 120)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	142	Target Neighborhood Hits	358	Shared Neighborhood Hits	67
SwissProt Accessions	Q923T7, Q5NCB6, Q99PQ5	Gene names	Trim7, Gnip
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein).

TRI25_HUMAN
NC score	0.084386 (rank : 121)	θ value	4.03905 (rank : 115)
Query Neighborhood Hits	142	Target Neighborhood Hits	472	Shared Neighborhood Hits	85
SwissProt Accessions	Q14258	Gene names	TRIM25, EFP, RNF147, ZNF147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp) (RING finger protein 147).

RN166_HUMAN
NC score	0.084342 (rank : 122)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	142	Target Neighborhood Hits	240	Shared Neighborhood Hits	82
SwissProt Accessions	Q96A37, Q96DM0	Gene names	RNF166
Domain Architecture	No domain graphic available
Description	RING finger protein 166.

RN125_HUMAN
NC score	0.084024 (rank : 123)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	142	Target Neighborhood Hits	230	Shared Neighborhood Hits	81
SwissProt Accessions	Q96EQ8, Q9NX39	Gene names	RNF125
Domain Architecture	No domain graphic available
Description	RING finger protein 125 (EC 6.3.2.-) (T-cell RING activation protein 1) (TRAC-1).

TRI62_MOUSE
NC score	0.083666 (rank : 124)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	142	Target Neighborhood Hits	478	Shared Neighborhood Hits	78
SwissProt Accessions	Q80V85	Gene names	Trim62
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 62.

TRI62_HUMAN
NC score	0.082545 (rank : 125)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	142	Target Neighborhood Hits	584	Shared Neighborhood Hits	78
SwissProt Accessions	Q9BVG3, Q9NVG0	Gene names	TRIM62
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 62.

TRI13_MOUSE
NC score	0.082307 (rank : 126)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	142	Target Neighborhood Hits	282	Shared Neighborhood Hits	78
SwissProt Accessions	Q9CYB0, Q8CEV0, Q923J0, Q925P1, Q99PQ0	Gene names	Trim13, Rfp2
Domain Architecture
Description	Tripartite motif-containing protein 13 (Ret finger protein 2) (Putative tumor suppressor RFP2).

RN125_MOUSE
NC score	0.082254 (rank : 127)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	142	Target Neighborhood Hits	220	Shared Neighborhood Hits	84
SwissProt Accessions	Q9D9R0, Q52KL4, Q8C7F2	Gene names	Rnf125
Domain Architecture	No domain graphic available
Description	RING finger protein 125 (EC 6.3.2.-).

RN166_MOUSE
NC score	0.081987 (rank : 128)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	142	Target Neighborhood Hits	248	Shared Neighborhood Hits	82
SwissProt Accessions	Q3U9F6	Gene names	Rnf166
Domain Architecture	No domain graphic available
Description	RING finger protein 166.

SMRA3_MOUSE
NC score	0.081655 (rank : 129)	θ value	2.36792 (rank : 98)
Query Neighborhood Hits	142	Target Neighborhood Hits	267	Shared Neighborhood Hits	87
SwissProt Accessions	Q6PCN7, O35596, O35597, Q80VT6	Gene names	Smarca3, Snf2l3, Zbu1
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 3) (TNF-response element-binding protein) (P113).

CAR15_HUMAN
NC score	0.079426 (rank : 130)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	142	Target Neighborhood Hits	77	Shared Neighborhood Hits	14
SwissProt Accessions	Q9HC29, Q96RH5, Q96RH6, Q96RH8	Gene names	CARD15, IBD1, NOD2
Domain Architecture
Description	Caspase recruitment domain-containing protein 15 (Protein Nod2) (Inflammatory bowel disease protein 1).

TRI13_HUMAN
NC score	0.078497 (rank : 131)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	142	Target Neighborhood Hits	274	Shared Neighborhood Hits	75
SwissProt Accessions	O60858, Q9BQ47, Q9C021	Gene names	TRIM13, LEU5, RFP2, RNF77
Domain Architecture
Description	Tripartite motif-containing protein 13 (Ret finger protein 2) (Putative tumor suppressor RFP2) (Leukemia-associated protein 5) (B- cell chronic lymphocytic leukemia tumor suppressor Leu5) (RING finger protein 77).

TRI59_MOUSE
NC score	0.078206 (rank : 132)	θ value	6.88961 (rank : 135)
Query Neighborhood Hits	142	Target Neighborhood Hits	292	Shared Neighborhood Hits	73
SwissProt Accessions	Q922Y2, Q9CSP2, Q9CUD5, Q9D740	Gene names	Trim59, Mrf1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 59 (RING finger protein 1).

TRI56_MOUSE
NC score	0.077412 (rank : 133)	θ value	1.38821 (rank : 92)
Query Neighborhood Hits	142	Target Neighborhood Hits	255	Shared Neighborhood Hits	73
SwissProt Accessions	Q80VI1, Q8CAY0	Gene names	Trim56
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 56.

BRCA1_MOUSE
NC score	0.076307 (rank : 134)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	142	Target Neighborhood Hits	436	Shared Neighborhood Hits	88
SwissProt Accessions	P48754, Q60957, Q60983	Gene names	Brca1
Domain Architecture
Description	Breast cancer type 1 susceptibility protein homolog.

MEFV_HUMAN
NC score	0.075293 (rank : 135)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	142	Target Neighborhood Hits	431	Shared Neighborhood Hits	49
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

ZC3H5_MOUSE
NC score	0.075010 (rank : 136)	θ value	2.36792 (rank : 103)
Query Neighborhood Hits	142	Target Neighborhood Hits	136	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BL48, Q8BVI6, Q99JZ8, Q99LL9	Gene names	Zc3h5, Kiaa1753, Zc3hdc5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

TRI59_HUMAN
NC score	0.074996 (rank : 137)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	142	Target Neighborhood Hits	307	Shared Neighborhood Hits	72
SwissProt Accessions	Q8IWR1	Gene names	TRIM59, RNF104, TRIM57, TSBF1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 59 (Tumor suppressor TSBF-1) (RING finger protein 104).

ZC3H5_HUMAN
NC score	0.074620 (rank : 138)	θ value	2.36792 (rank : 102)
Query Neighborhood Hits	142	Target Neighborhood Hits	134	Shared Neighborhood Hits	20
SwissProt Accessions	Q9C0B0	Gene names	ZC3H5, KIAA1753, ZC3HDC5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

CHFR_HUMAN
NC score	0.074181 (rank : 139)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	142	Target Neighborhood Hits	255	Shared Neighborhood Hits	76
SwissProt Accessions	Q96EP1, Q96SL3, Q9NRT4, Q9NT32, Q9NVD5	Gene names	CHFR
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

RFPL2_HUMAN
NC score	0.074017 (rank : 140)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	142	Target Neighborhood Hits	126	Shared Neighborhood Hits	58
SwissProt Accessions	O75678	Gene names	RFPL2, RNF79
Domain Architecture
Description	Ret finger protein-like 2 (RING finger protein 79).

BRCA1_HUMAN
NC score	0.073747 (rank : 141)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	142	Target Neighborhood Hits	381	Shared Neighborhood Hits	87
SwissProt Accessions	P38398	Gene names	BRCA1, RNF53
Domain Architecture
Description	Breast cancer type 1 susceptibility protein (RING finger protein 53).

MEFV_MOUSE
NC score	0.073312 (rank : 142)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	142	Target Neighborhood Hits	236	Shared Neighborhood Hits	49
SwissProt Accessions	Q9JJ26	Gene names	Mefv
Domain Architecture
Description	Pyrin (Marenostrin).

TRI47_MOUSE
NC score	0.073022 (rank : 143)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	142	Target Neighborhood Hits	295	Shared Neighborhood Hits	79
SwissProt Accessions	Q8C0E3, Q6P249, Q811J7, Q8BVZ8, Q8R1K0, Q8R3Y1	Gene names	Trim47
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47.

TRI37_HUMAN
NC score	0.072927 (rank : 144)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	142	Target Neighborhood Hits	307	Shared Neighborhood Hits	76
SwissProt Accessions	O94972, Q7Z3E6, Q8IYF7, Q8WYF7	Gene names	TRIM37, KIAA0898, MUL, POB1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37 (Mulibrey nanism protein).

TRIM3_HUMAN
NC score	0.072883 (rank : 145)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	142	Target Neighborhood Hits	357	Shared Neighborhood Hits	80
SwissProt Accessions	O75382, Q9C038, Q9C039	Gene names	TRIM3, BERP, RNF22, RNF97
Domain Architecture
Description	Tripartite motif-containing protein 3 (RING finger protein 22) (Brain- expressed RING finger protein) (RING finger protein 97).

TRI37_MOUSE
NC score	0.072852 (rank : 146)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	142	Target Neighborhood Hits	316	Shared Neighborhood Hits	76
SwissProt Accessions	Q6PCX9, Q8CHC5	Gene names	Trim37, Kiaa0898
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37.

NAL10_MOUSE
NC score	0.072625 (rank : 147)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	142	Target Neighborhood Hits	46	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CCN1	Gene names	Nalp10, Pynod
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10.

CHFR_MOUSE
NC score	0.071822 (rank : 148)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	142	Target Neighborhood Hits	264	Shared Neighborhood Hits	79
SwissProt Accessions	Q810L3, Q8BJZ9, Q8BWH4	Gene names	Chfr
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

TRI47_HUMAN
NC score	0.071510 (rank : 149)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	142	Target Neighborhood Hits	286	Shared Neighborhood Hits	77
SwissProt Accessions	Q96LD4, Q96GU5, Q9BRN7	Gene names	TRIM47, GOA, RNF100
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47 (Gene overexpressed in astrocytoma protein) (RING finger protein 100).

TRIM8_MOUSE
NC score	0.071362 (rank : 150)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	142	Target Neighborhood Hits	674	Shared Neighborhood Hits	72
SwissProt Accessions	Q99PJ2, Q8C508, Q8C700, Q8CGI2, Q99PQ4	Gene names	Trim8, Gerp, Rnf27
Domain Architecture
Description	Tripartite motif-containing protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein).

TRIM8_HUMAN
NC score	0.070679 (rank : 151)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	142	Target Neighborhood Hits	650	Shared Neighborhood Hits	70
SwissProt Accessions	Q9BZR9, Q9C028	Gene names	TRIM8, GERP, RNF27
Domain Architecture
Description	Tripartite motif-containing protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein).

TRI46_HUMAN
NC score	0.070653 (rank : 152)	θ value	5.27518 (rank : 124)
Query Neighborhood Hits	142	Target Neighborhood Hits	291	Shared Neighborhood Hits	77
SwissProt Accessions	Q7Z4K8, Q6NT17, Q6NT41, Q6ZRL7, Q9H5P2	Gene names	TRIM46, TRIFIC
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 46 (Tripartite, fibronectin type- III and C-terminal SPRY motif protein).

TRI32_HUMAN
NC score	0.070591 (rank : 153)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	142	Target Neighborhood Hits	264	Shared Neighborhood Hits	74
SwissProt Accessions	Q13049, Q9NQP8	Gene names	TRIM32, HT2A
Domain Architecture
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-) (Zinc finger protein HT2A) (72 kDa Tat-interacting protein).

TRI18_HUMAN
NC score	0.070570 (rank : 154)	θ value	4.03905 (rank : 113)
Query Neighborhood Hits	142	Target Neighborhood Hits	307	Shared Neighborhood Hits	82
SwissProt Accessions	O15344, O75361, Q9BZX5	Gene names	MID1, FXY, RNF59, TRIM18, XPRF
Domain Architecture
Description	Midline-1 (EC 6.3.2.-) (Tripartite motif-containing protein 18) (Putative transcription factor XPRF) (Midin) (RING finger protein 59) (Midline 1 RING finger protein).

BFAR_MOUSE
NC score	0.070546 (rank : 155)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	142	Target Neighborhood Hits	232	Shared Neighborhood Hits	74
SwissProt Accessions	Q8R079, Q8C1A7, Q9CXY3	Gene names	Bfar
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator.

RFPL3_HUMAN
NC score	0.070418 (rank : 156)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	142	Target Neighborhood Hits	134	Shared Neighborhood Hits	55
SwissProt Accessions	O75679, Q6IC04	Gene names	RFPL3
Domain Architecture
Description	Ret finger protein-like 3.

TRI46_MOUSE
NC score	0.070150 (rank : 157)	θ value	5.27518 (rank : 125)
Query Neighborhood Hits	142	Target Neighborhood Hits	287	Shared Neighborhood Hits	76
SwissProt Accessions	Q7TNM2, Q60717, Q6P1I9	Gene names	Trim46, Trific
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 46 (Tripartite, fibronectin type- III and C-terminal SPRY motif protein).

TRI18_MOUSE
NC score	0.069915 (rank : 158)	θ value	4.03905 (rank : 114)
Query Neighborhood Hits	142	Target Neighborhood Hits	292	Shared Neighborhood Hits	83
SwissProt Accessions	O70583, O35418, Q7TPT6	Gene names	Mid1, Fxy, Trim18
Domain Architecture
Description	Midline-1 (EC 6.3.2.-) (Tripartite motif-containing protein 18) (Midin).

TRI32_MOUSE
NC score	0.069701 (rank : 159)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	142	Target Neighborhood Hits	271	Shared Neighborhood Hits	74
SwissProt Accessions	Q8CH72, Q8K055	Gene names	Trim32
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-).

TRIM2_HUMAN
NC score	0.069698 (rank : 160)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	142	Target Neighborhood Hits	330	Shared Neighborhood Hits	83
SwissProt Accessions	Q9C040, O60272, Q9BSI9, Q9UFZ1	Gene names	TRIM2, KIAA0517, RNF86
Domain Architecture
Description	Tripartite motif-containing protein 2 (RING finger protein 86).

BFAR_HUMAN
NC score	0.069547 (rank : 161)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	142	Target Neighborhood Hits	222	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NZS9	Gene names	BFAR, BAR, RNF47
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator (RING finger protein 47).

TRIM2_MOUSE
NC score	0.069444 (rank : 162)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	142	Target Neighborhood Hits	331	Shared Neighborhood Hits	83
SwissProt Accessions	Q9ESN6, Q3UHP5, Q8C981	Gene names	Trim2, Narf
Domain Architecture
Description	Tripartite motif-containing protein 2 (Neural activity-related RING finger protein).

RNF39_HUMAN
NC score	0.069106 (rank : 163)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	142	Target Neighborhood Hits	200	Shared Neighborhood Hits	62
SwissProt Accessions	Q9H2S5, Q5SPM8, Q5SPM9, Q5SPN0, Q5SRJ9, Q5SRK1, Q5SS29, Q9H2S3, Q9H2S4	Gene names	RNF39, HZFW
Domain Architecture	No domain graphic available
Description	RING finger protein 39 (Protein HZFw).

TRI55_HUMAN
NC score	0.068652 (rank : 164)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	142	Target Neighborhood Hits	292	Shared Neighborhood Hits	62
SwissProt Accessions	Q9BYV6, Q53XX3, Q8IUD9, Q8IUE4, Q96DV2, Q96DV3, Q9BYV5	Gene names	TRIM55, MURF2, RNF29
Domain Architecture
Description	Tripartite motif-containing protein 55 (Muscle-specific RING finger protein 2) (MuRF2) (MURF-2) (RING finger protein 29).

RFPL1_HUMAN
NC score	0.068619 (rank : 165)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	142	Target Neighborhood Hits	119	Shared Neighborhood Hits	49
SwissProt Accessions	O75677, Q6IC06	Gene names	RFPL1, RFPL1L, RNF78
Domain Architecture
Description	Ret finger protein-like 1 (RING finger protein 78).

NALP1_HUMAN
NC score	0.068462 (rank : 166)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	142	Target Neighborhood Hits	138	Shared Neighborhood Hits	9
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

ICBR_HUMAN
NC score	0.067642 (rank : 167)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	142	Target Neighborhood Hits	11	Shared Neighborhood Hits	6
SwissProt Accessions	P57730	Gene names	ICEBERG
Domain Architecture
Description	Caspase-1 inhibitor Iceberg.

RING1_HUMAN
NC score	0.067318 (rank : 168)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	142	Target Neighborhood Hits	219	Shared Neighborhood Hits	76
SwissProt Accessions	Q06587, Q5JP96, Q5SQW2, Q86V19	Gene names	RING1, RNF1
Domain Architecture
Description	Polycomb complex protein RING1 (RING finger protein 1).

RNF4_HUMAN
NC score	0.066974 (rank : 169)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	142	Target Neighborhood Hits	212	Shared Neighborhood Hits	70
SwissProt Accessions	P78317	Gene names	RNF4
Domain Architecture
Description	RING finger protein 4.

ERMAP_HUMAN
NC score	0.066643 (rank : 170)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	142	Target Neighborhood Hits	155	Shared Neighborhood Hits	40
SwissProt Accessions	Q96PL5, Q5VV53, Q6DUE0, Q7Z3X0, Q8NCV8, Q8NCW2, Q8NCW3, Q96PL6	Gene names	ERMAP, RD, SC
Domain Architecture	No domain graphic available
Description	Erythroid membrane-associated protein precursor (hERMAP) (Scianna blood group antigen) (Radin blood group antigen).

RING1_MOUSE
NC score	0.066004 (rank : 171)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	142	Target Neighborhood Hits	220	Shared Neighborhood Hits	76
SwissProt Accessions	O35730, Q3U242, Q3U333, Q4FK33, Q63ZX8, Q921Z8	Gene names	Ring1, Ring1A, Rnf1
Domain Architecture	No domain graphic available
Description	Polycomb complex protein RING1 (RING finger protein 1) (Transcription repressor Ring1A).

TRIM3_MOUSE
NC score	0.065882 (rank : 172)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	142	Target Neighborhood Hits	351	Shared Neighborhood Hits	75
SwissProt Accessions	Q9R1R2, Q3UMU5	Gene names	Trim3, Hac1, Rnf22
Domain Architecture
Description	Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1).

TRI63_MOUSE
NC score	0.065782 (rank : 173)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	142	Target Neighborhood Hits	240	Shared Neighborhood Hits	61
SwissProt Accessions	Q38HM4, Q8BWC4	Gene names	Trim63, Murf1, Rf1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase TRIM63 (EC 6.3.2.-) (Tripartite motif-containing protein 63) (Muscle-specific RING finger protein 1) (MuRF1) (MURF-1) (Muscle RING finger protein 1).

TRI63_HUMAN
NC score	0.065398 (rank : 174)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	142	Target Neighborhood Hits	298	Shared Neighborhood Hits	62
SwissProt Accessions	Q969Q1, Q5T2I1, Q96BD3, Q96KD9, Q9BYV4	Gene names	TRIM63, IRF, MURF1, RNF28, SMRZ
Domain Architecture
Description	Ubiquitin ligase TRIM63 (EC 6.3.2.-) (Tripartite motif-containing protein 63) (Muscle-specific RING finger protein 1) (MuRF1) (MURF-1) (RING finger protein 28) (Striated muscle RING zinc finger protein) (Iris RING finger protein).

TRIM1_HUMAN
NC score	0.065199 (rank : 175)	θ value	5.27518 (rank : 127)
Query Neighborhood Hits	142	Target Neighborhood Hits	345	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UJV3, Q5JYF5, Q8WWK1, Q9UJR9	Gene names	MID2, FXY2, RNF60, TRIM1
Domain Architecture
Description	Midline-2 (Midline defect 2) (Tripartite motif-containing protein 1) (Midin-2) (RING finger protein 60).

TRIM1_MOUSE
NC score	0.064241 (rank : 176)	θ value	5.27518 (rank : 128)
Query Neighborhood Hits	142	Target Neighborhood Hits	361	Shared Neighborhood Hits	85
SwissProt Accessions	Q9QUS6	Gene names	Mid2, Fxy2, Trim1
Domain Architecture
Description	Midline-2 (Midline defect 2) (Tripartite motif-containing protein 1).

NALP2_HUMAN
NC score	0.063598 (rank : 177)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	142	Target Neighborhood Hits	65	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NX02, Q53FL5, Q59G09, Q8IXT0, Q9BVN5, Q9H6G6, Q9HAV9, Q9NWK3	Gene names	NALP2, NBS1, PAN1, PYPAF2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 2 (PYRIN domain and NACHT domain-containing protein 1) (PYRIN-containing APAF1-like protein 2) (Nucleotide-binding site protein 1).

RNF4_MOUSE
NC score	0.062777 (rank : 178)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	142	Target Neighborhood Hits	212	Shared Neighborhood Hits	70
SwissProt Accessions	Q9QZS2, O35941, Q541Z6	Gene names	Rnf4
Domain Architecture
Description	RING finger protein 4.

BSPRY_MOUSE
NC score	0.061970 (rank : 179)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	142	Target Neighborhood Hits	163	Shared Neighborhood Hits	45
SwissProt Accessions	Q80YW5, Q3TU74, Q8BZF0, Q99KV7, Q9ER70	Gene names	Bspry
Domain Architecture	No domain graphic available
Description	B box and SPRY domain-containing protein.

SMRA3_HUMAN
NC score	0.061758 (rank : 180)	θ value	8.99809 (rank : 139)
Query Neighborhood Hits	142	Target Neighborhood Hits	265	Shared Neighborhood Hits	85
SwissProt Accessions	Q14527, Q14536, Q16051, Q7KYJ6, Q86YA5, Q92652, Q96KM9	Gene names	SMARCA3, HIP116A, HLTF, SNF2L3, ZBU1
Domain Architecture	No domain graphic available
Description	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3 (EC 3.6.1.-) (Sucrose nonfermenting protein 2-like 3) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (Helicase-like transcription factor) (HIP116).

BSPRY_HUMAN
NC score	0.060713 (rank : 181)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	142	Target Neighborhood Hits	115	Shared Neighborhood Hits	44
SwissProt Accessions	Q5W0U4, Q96DJ2, Q9H4E4, Q9NXN0	Gene names	BSPRY
Domain Architecture	No domain graphic available
Description	B box and SPRY domain-containing protein.

TRI54_MOUSE
NC score	0.060640 (rank : 182)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	142	Target Neighborhood Hits	197	Shared Neighborhood Hits	60
SwissProt Accessions	Q9ERP3	Gene names	Trim54, Murf, Rnf30
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 54 (Muscle-specific RING finger protein 3) (MuRF3) (MURF-3) (Muscle-specific RING finger protein) (MuRF) (RING finger protein 30).

TRI54_HUMAN
NC score	0.060483 (rank : 183)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	142	Target Neighborhood Hits	209	Shared Neighborhood Hits	61
SwissProt Accessions	Q9BYV2, Q53SY4, Q9BYV3	Gene names	TRIM54, MURF, MURF3, RNF30
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 54 (Muscle-specific RING finger protein 3) (MuRF3) (MURF-3) (Muscle-specific RING finger protein) (MuRF) (RING finger protein 30).

TRI14_MOUSE
NC score	0.060091 (rank : 184)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	142	Target Neighborhood Hits	137	Shared Neighborhood Hits	45
SwissProt Accessions	Q8BVW3, Q6A0C3, Q762I6, Q9D3G8	Gene names	Trim14, Kiaa0129, Pub
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 14 (PU.1-binding protein).

ERMAP_MOUSE
NC score	0.060016 (rank : 185)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	142	Target Neighborhood Hits	231	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JLN5, Q3UV82, Q6P4T5, Q8CEH1	Gene names	Ermap
Domain Architecture	No domain graphic available
Description	Erythroid membrane-associated protein precursor.

TRI14_HUMAN
NC score	0.059865 (rank : 186)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	142	Target Neighborhood Hits	143	Shared Neighborhood Hits	44
SwissProt Accessions	Q14142, Q9BRD8, Q9C020	Gene names	TRIM14, KIAA0129
Domain Architecture
Description	Tripartite motif-containing protein 14.

RN146_HUMAN
NC score	0.059858 (rank : 187)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	142	Target Neighborhood Hits	162	Shared Neighborhood Hits	69
SwissProt Accessions	Q9NTX7, Q6FIB2, Q7L8H4, Q96K03, Q9NTX6	Gene names	RNF146
Domain Architecture	No domain graphic available
Description	RING finger protein 146 (Dactylidin).

CASP1_HUMAN
NC score	0.059707 (rank : 188)	θ value	0.0330416 (rank : 50)
Query Neighborhood Hits	142	Target Neighborhood Hits	41	Shared Neighborhood Hits	11
SwissProt Accessions	P29466, Q9UCN3	Gene names	CASP1, IL1BC, IL1BCE
Domain Architecture
Description	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].

TRI16_MOUSE
NC score	0.059371 (rank : 189)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	142	Target Neighborhood Hits	196	Shared Neighborhood Hits	47
SwissProt Accessions	Q99PP9, Q7TPY6, Q8C332, Q8C6V0	Gene names	Trim16, Ebbp
Domain Architecture
Description	Tripartite motif-containing protein 16 (Estrogen-responsive B box protein).

RN146_MOUSE
NC score	0.059023 (rank : 190)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	142	Target Neighborhood Hits	161	Shared Neighborhood Hits	69
SwissProt Accessions	Q9CZW6, Q3TF93	Gene names	Rnf146
Domain Architecture	No domain graphic available
Description	RING finger protein 146.

RING2_HUMAN
NC score	0.058924 (rank : 191)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	142	Target Neighborhood Hits	201	Shared Neighborhood Hits	73
SwissProt Accessions	Q99496, Q5TEN1, Q5TEN2	Gene names	RNF2, BAP1, DING, HIPI3, RING1B
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein RING2 (EC 6.3.2.-) (RING finger protein 2) (RING finger protein 1B) (RING1b) (RING finger protein BAP-1) (DinG protein) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3).

RING2_MOUSE
NC score	0.058920 (rank : 192)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	142	Target Neighborhood Hits	199	Shared Neighborhood Hits	73
SwissProt Accessions	Q9CQJ4, O35699, O35729, Q4FJV5, Q8C1X8	Gene names	Rnf2, DinG, Ring1b
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein RING2 (EC 6.3.2.-) (RING finger protein 2) (RING finger protein 1B) (RING1b).

BT1A1_MOUSE
NC score	0.058752 (rank : 193)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	142	Target Neighborhood Hits	252	Shared Neighborhood Hits	40
SwissProt Accessions	Q62556, P97392, Q8K2H7, Q921K7	Gene names	Btn1a1, Btn
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

NAL13_HUMAN
NC score	0.058619 (rank : 194)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	142	Target Neighborhood Hits	93	Shared Neighborhood Hits	9
SwissProt Accessions	Q86W25, Q7RTR5	Gene names	NALP13, NOD14
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 13 (Nucleotide-binding oligomerization domain protein 14).

NAL10_HUMAN
NC score	0.058542 (rank : 195)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	142	Target Neighborhood Hits	55	Shared Neighborhood Hits	9
SwissProt Accessions	Q86W26, Q6JGT0	Gene names	NALP10, NOD8, PYNOD
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10 (Nucleotide-binding oligomerization domain protein 8).

NALP7_HUMAN
NC score	0.057956 (rank : 196)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	142	Target Neighborhood Hits	65	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

BTNL3_HUMAN
NC score	0.057934 (rank : 197)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	142	Target Neighborhood Hits	143	Shared Neighborhood Hits	38
SwissProt Accessions	Q6UXE8, Q9Y2C7	Gene names	BTNL3, BTNLR, COLF4100
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 3 precursor (Butyrophilin-like receptor).

BT2A2_HUMAN
NC score	0.057473 (rank : 198)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	142	Target Neighborhood Hits	191	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WVV5, O00480	Gene names	BTN2A2, BT2.2, BTF2
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A2 precursor.

BT1A1_HUMAN
NC score	0.057328 (rank : 199)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	142	Target Neighborhood Hits	322	Shared Neighborhood Hits	40
SwissProt Accessions	Q13410, Q9H458	Gene names	BTN1A1, BTN
Domain Architecture
Description	Butyrophilin subfamily 1 member A1 precursor (BT).

BT2A3_HUMAN
NC score	0.057310 (rank : 200)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	142	Target Neighborhood Hits	195	Shared Neighborhood Hits	38
SwissProt Accessions	Q96KV6	Gene names	BTN2A3
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A3 precursor.

BT3A3_HUMAN
NC score	0.056997 (rank : 201)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	142	Target Neighborhood Hits	233	Shared Neighborhood Hits	40
SwissProt Accessions	O00478	Gene names	BTN3A3, BTF3
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A3 precursor.

BT3A1_HUMAN
NC score	0.056208 (rank : 202)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	142	Target Neighborhood Hits	229	Shared Neighborhood Hits	40
SwissProt Accessions	O00481, Q99420, Q9HCY1	Gene names	BTN3A1, BTF5
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 3 member A1 precursor (CD277 antigen).

TRI44_MOUSE
NC score	0.055967 (rank : 203)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	142	Target Neighborhood Hits	327	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QXA7, Q80SV9, Q9JHR8	Gene names	Trim44, Dipb
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 44 (Protein DIPB) (Protein Mc7).

BTNL9_HUMAN
NC score	0.055945 (rank : 204)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	142	Target Neighborhood Hits	125	Shared Neighborhood Hits	40
SwissProt Accessions	Q6UXG8, Q6P660, Q96DM5	Gene names	BTNL9
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 9 precursor.

BT2A1_HUMAN
NC score	0.055600 (rank : 205)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	142	Target Neighborhood Hits	185	Shared Neighborhood Hits	38
SwissProt Accessions	Q7KYR7, O00475, P78408, Q7KYQ7, Q7Z386, Q9NU62	Gene names	BTN2A1, BT2.1, BTF1
Domain Architecture	No domain graphic available
Description	Butyrophilin subfamily 2 member A1 precursor.

BTNL8_HUMAN
NC score	0.055404 (rank : 206)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	142	Target Neighborhood Hits	177	Shared Neighborhood Hits	38
SwissProt Accessions	Q6UX41, Q9H730	Gene names	BTNL8
Domain Architecture	No domain graphic available
Description	Butyrophilin-like protein 8 precursor.

CARD4_MOUSE
NC score	0.055276 (rank : 207)	θ value	2.36792 (rank : 97)
Query Neighborhood Hits	142	Target Neighborhood Hits	85	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BHB0, Q8BUT6	Gene names	Card4
Domain Architecture
Description	Caspase recruitment domain-containing protein 4.

TRI44_HUMAN
NC score	0.053966 (rank : 208)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	142	Target Neighborhood Hits	393	Shared Neighborhood Hits	46
SwissProt Accessions	Q96DX7, Q96QY2, Q9UGK0	Gene names	TRIM44, DIPB
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 44 (Protein DIPB).

NALP4_HUMAN
NC score	0.053742 (rank : 209)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	142	Target Neighborhood Hits	81	Shared Neighborhood Hits	10
SwissProt Accessions	Q96MN2, Q86W87, Q96AY6	Gene names	NALP4, PAN2, PYPAF4, RNH2
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 4 (PYRIN-containing APAF1-like protein 4) (PAAD and NACHT-containing protein 2) (PYRIN and NACHT- containing protein 2) (Ribonuclease inhibitor 2).

TRI16_HUMAN
NC score	0.053719 (rank : 210)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	142	Target Neighborhood Hits	231	Shared Neighborhood Hits	49
SwissProt Accessions	O95361, Q7Z6I2, Q96BE8, Q96J43	Gene names	TRIM16, EBBP
Domain Architecture
Description	Tripartite motif-containing protein 16 (Estrogen-responsive B box protein).

SPRY4_MOUSE
NC score	0.051661 (rank : 211)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	142	Target Neighborhood Hits	82	Shared Neighborhood Hits	39
SwissProt Accessions	Q91WK1, Q8BUS6, Q9D651	Gene names	Spryd4
Domain Architecture	No domain graphic available
Description	SPRY domain-containing protein 4.

CARD4_HUMAN
NC score	0.047598 (rank : 212)	θ value	0.0961366 (rank : 53)
Query Neighborhood Hits	142	Target Neighborhood Hits	102	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y239, Q8IWF5	Gene names	CARD4, NOD1
Domain Architecture
Description	Caspase recruitment domain-containing protein 4 (Protein Nod1).

CARD6_HUMAN
NC score	0.047474 (rank : 213)	θ value	0.813845 (rank : 80)
Query Neighborhood Hits	142	Target Neighborhood Hits	145	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BX69	Gene names	CARD6
Domain Architecture
Description	Caspase recruitment domain-containing protein 6.

CASP1_MOUSE
NC score	0.044843 (rank : 214)	θ value	1.06291 (rank : 86)
Query Neighborhood Hits	142	Target Neighborhood Hits	38	Shared Neighborhood Hits	11
SwissProt Accessions	P29452	Gene names	Casp1, Il1bc
Domain Architecture
Description	Caspase-1 precursor (EC 3.4.22.36) (CASP-1) (Interleukin-1 beta convertase) (IL-1BC) (IL-1 beta-converting enzyme) (ICE) (Interleukin- 1 beta-converting enzyme) (p45) [Contains: Caspase-1 p20 subunit; Caspase-1 p10 subunit].

BRE1B_MOUSE
NC score	0.044790 (rank : 215)	θ value	0.813845 (rank : 79)
Query Neighborhood Hits	142	Target Neighborhood Hits	970	Shared Neighborhood Hits	74
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

BRE1B_HUMAN
NC score	0.042942 (rank : 216)	θ value	0.813845 (rank : 78)
Query Neighborhood Hits	142	Target Neighborhood Hits	1040	Shared Neighborhood Hits	75
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

CASP2_HUMAN
NC score	0.041302 (rank : 217)	θ value	1.06291 (rank : 87)
Query Neighborhood Hits	142	Target Neighborhood Hits	31	Shared Neighborhood Hits	8
SwissProt Accessions	P42575, P42576, Q59F21, Q7KZL6, Q86UJ3, Q9BUP7, Q9BZK9	Gene names	CASP2, ICH1
Domain Architecture
Description	Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (ICH- 1L/1S) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].

CASP2_MOUSE
NC score	0.040141 (rank : 218)	θ value	1.06291 (rank : 88)
Query Neighborhood Hits	142	Target Neighborhood Hits	34	Shared Neighborhood Hits	6
SwissProt Accessions	P29594, O08737, Q3TCM0, Q8C9H7, Q8K241	Gene names	Casp2, Ich1, Nedd-2, Nedd2
Domain Architecture
Description	Caspase-2 precursor (EC 3.4.22.-) (CASP-2) (ICH-1 protease) (NEDD2 protein) (Neural precursor cell expressed developmentally down- regulated protein 2) (NEDD-2) [Contains: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12].

RBBP6_MOUSE
NC score	0.039333 (rank : 219)	θ value	4.03905 (rank : 110)
Query Neighborhood Hits	142	Target Neighborhood Hits	1014	Shared Neighborhood Hits	69
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

RBBP6_HUMAN
NC score	0.035543 (rank : 220)	θ value	4.03905 (rank : 109)
Query Neighborhood Hits	142	Target Neighborhood Hits	1135	Shared Neighborhood Hits	70
SwissProt Accessions	Q7Z6E9, Q15290, Q6DKH4, Q6P4C2, Q6YNC9, Q7Z6E8, Q8N0V2, Q96PH3, Q9H3I8, Q9H5M5, Q9NPX4	Gene names	RBBP6, P2PR, PACT, RBQ1
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R) (Retinoblastoma-binding Q protein 1) (Protein RBQ-1).

PZRN4_HUMAN
NC score	0.033961 (rank : 221)	θ value	6.88961 (rank : 132)
Query Neighborhood Hits	142	Target Neighborhood Hits	438	Shared Neighborhood Hits	78
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

BRE1A_HUMAN
NC score	0.031974 (rank : 222)	θ value	1.06291 (rank : 84)
Query Neighborhood Hits	142	Target Neighborhood Hits	1071	Shared Neighborhood Hits	65
SwissProt Accessions	Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83	Gene names	RNF20, BRE1A
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (hBRE1) (RING finger protein 20).

BRE1A_MOUSE
NC score	0.030918 (rank : 223)	θ value	1.06291 (rank : 85)
Query Neighborhood Hits	142	Target Neighborhood Hits	1025	Shared Neighborhood Hits	62
SwissProt Accessions	Q5DTM8, Q3UT10, Q3V350, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4	Gene names	Rnf20, Bre1a, Kiaa4116
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (RING finger protein 20).

STON2_HUMAN
NC score	0.026517 (rank : 224)	θ value	0.0961366 (rank : 54)
Query Neighborhood Hits	142	Target Neighborhood Hits	115	Shared Neighborhood Hits	3
SwissProt Accessions	Q8WXE9, Q6NT47, Q96RI7, Q96RU6	Gene names	STON2, STN2, STNB
Domain Architecture
Description	Stonin-2 (Stoned B).

RYR3_HUMAN
NC score	0.022079 (rank : 225)	θ value	0.21417 (rank : 67)
Query Neighborhood Hits	142	Target Neighborhood Hits	134	Shared Neighborhood Hits	4
SwissProt Accessions	Q15413, O15175, Q15412	Gene names	RYR3, HBRR
Domain Architecture
Description	Ryanodine receptor 3 (Brain-type ryanodine receptor) (RyR3) (RYR-3) (Brain ryanodine receptor-calcium release channel).

RIPK2_MOUSE
NC score	0.017243 (rank : 226)	θ value	0.0193708 (rank : 49)
Query Neighborhood Hits	142	Target Neighborhood Hits	776	Shared Neighborhood Hits	9
SwissProt Accessions	P58801	Gene names	Ripk2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1).

RIPK2_HUMAN
NC score	0.015734 (rank : 227)	θ value	0.0563607 (rank : 52)
Query Neighborhood Hits	142	Target Neighborhood Hits	774	Shared Neighborhood Hits	9
SwissProt Accessions	O43353, Q6UWF0	Gene names	RIPK2, CARDIAK, RICK, RIP2
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (RIP-like-interacting CLARP kinase) (Receptor-interacting protein 2) (RIP-2) (CARD-containing interleukin-1 beta-converting enzyme- associated kinase) (CARD-containing IL-1 beta ICE-kinase).

ATP7B_MOUSE
NC score	0.012735 (rank : 228)	θ value	0.813845 (rank : 77)
Query Neighborhood Hits	142	Target Neighborhood Hits	66	Shared Neighborhood Hits	2
SwissProt Accessions	Q64446	Gene names	Atp7b, Wnd
Domain Architecture
Description	Copper-transporting ATPase 2 (EC 3.6.3.4) (Copper pump 2) (Wilson disease-associated protein homolog).

LAMC2_HUMAN
NC score	0.010733 (rank : 229)	θ value	0.62314 (rank : 75)
Query Neighborhood Hits	142	Target Neighborhood Hits	715	Shared Neighborhood Hits	7
SwissProt Accessions	Q13753, Q02536, Q02537, Q13752, Q14941, Q5VYE8	Gene names	LAMC2
Domain Architecture
Description	Laminin gamma-2 chain precursor (Laminin 5 gamma 2 subunit) (Kalinin/nicein/epiligrin 100 kDa subunit) (Laminin B2t chain) (Cell- scattering factor 140 kDa subunit) (CSF 140 kDa subunit) (Large adhesive scatter factor 140 kDa subunit) (Ladsin 140 kDa subunit).

ADCK1_HUMAN
NC score	0.009249 (rank : 230)	θ value	6.88961 (rank : 129)
Query Neighborhood Hits	142	Target Neighborhood Hits	25	Shared Neighborhood Hits	2
SwissProt Accessions	Q86TW2, Q6PD65	Gene names	ADCK1
Domain Architecture	No domain graphic available
Description	Uncharacterized aarF domain-containing protein kinase 1 precursor (EC 2.7.-.-).

FANCJ_MOUSE
NC score	0.007081 (rank : 231)	θ value	6.88961 (rank : 131)
Query Neighborhood Hits	142	Target Neighborhood Hits	57	Shared Neighborhood Hits	3
SwissProt Accessions	Q5SXJ3, Q8BJQ8, Q8BKI6	Gene names	Brip1, Bach1, Fancj
Domain Architecture	No domain graphic available
Description	Fanconi anemia group J protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase BRIP1) (Protein FACJ) (BRCA1-interacting protein C-terminal helicase 1) (BRCA1-interacting protein 1) (BRCA1-associated C-terminal helicase 1).

ESCO2_MOUSE
NC score	0.006529 (rank : 232)	θ value	8.99809 (rank : 137)
Query Neighborhood Hits	142	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CIB9, Q3UMT6, Q6IQX5, Q8BNG9, Q8BQF8, Q9CRI8	Gene names	Esco2
Domain Architecture	No domain graphic available
Description	N-acetyltransferase ESCO2 (EC 2.3.1.-) (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2).

DYH11_HUMAN
NC score	0.004778 (rank : 233)	θ value	6.88961 (rank : 130)
Query Neighborhood Hits	142	Target Neighborhood Hits	234	Shared Neighborhood Hits	5
SwissProt Accessions	Q96DT5, Q9UJ82	Gene names	DNAH11
Domain Architecture
Description	Ciliary dynein heavy chain 11 (Axonemal beta dynein heavy chain 11).

SMC4_HUMAN
NC score	0.002035 (rank : 234)	θ value	5.27518 (rank : 123)
Query Neighborhood Hits	142	Target Neighborhood Hits	937	Shared Neighborhood Hits	13
SwissProt Accessions	Q9NTJ3, O95752, Q8NDL4, Q9UNT9	Gene names	SMC4L1, CAPC, SMC4
Domain Architecture
Description	Structural maintenance of chromosomes 4-like 1 protein (Chromosome- associated polypeptide C) (hCAP-C) (XCAP-C homolog).

MYH9_MOUSE
NC score	0.000940 (rank : 235)	θ value	8.99809 (rank : 138)
Query Neighborhood Hits	142	Target Neighborhood Hits	1829	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).