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Network neighborhood for query Sequence : MIB1_MOUSE

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MIB1_MOUSE
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MIB1_HUMAN
θ value	0 (rank : 1)	NC score	0.999540 (rank : 2)
Query Neighborhood Hits	471	Target Neighborhood Hits	470	Shared Neighborhood Hits	460
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

MIB1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	471	Target Neighborhood Hits	471	Shared Neighborhood Hits	471
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

MIB2_HUMAN
θ value	0 (rank : 3)	NC score	0.972018 (rank : 3)
Query Neighborhood Hits	471	Target Neighborhood Hits	438	Shared Neighborhood Hits	385
SwissProt Accessions	Q96AX9, Q7Z437, Q8IY62, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1	Gene names	MIB2, SKD, ZZANK1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Zinc finger ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) (Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating protein 002N).

MIB2_MOUSE
θ value	0 (rank : 4)	NC score	0.970539 (rank : 4)
Query Neighborhood Hits	471	Target Neighborhood Hits	409	Shared Neighborhood Hits	375
SwissProt Accessions	Q8R516, Q52QU8, Q6PEF6, Q8C1N7, Q8VIB4	Gene names	Mib2, Skd
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin) (Dystrophin-like protein) (Dyslike).

ANK3_HUMAN
θ value	1.20211e-36 (rank : 5)	NC score	0.868977 (rank : 34)
Query Neighborhood Hits	471	Target Neighborhood Hits	853	Shared Neighborhood Hits	310
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

ANK2_HUMAN
θ value	4.27553e-34 (rank : 6)	NC score	0.813587 (rank : 104)
Query Neighborhood Hits	471	Target Neighborhood Hits	1615	Shared Neighborhood Hits	307
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

ANR28_MOUSE
θ value	7.29293e-34 (rank : 7)	NC score	0.890178 (rank : 11)
Query Neighborhood Hits	471	Target Neighborhood Hits	314	Shared Neighborhood Hits	300
SwissProt Accessions	Q505D1	Gene names	Ankrd28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ANR28_HUMAN
θ value	2.77131e-33 (rank : 8)	NC score	0.889320 (rank : 12)
Query Neighborhood Hits	471	Target Neighborhood Hits	314	Shared Neighborhood Hits	299
SwissProt Accessions	O15084, Q6ULS0, Q6ZT57	Gene names	ANKRD28, KIAA0379
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ANK1_MOUSE
θ value	1.0531e-32 (rank : 9)	NC score	0.876444 (rank : 26)
Query Neighborhood Hits	471	Target Neighborhood Hits	430	Shared Neighborhood Hits	306
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

ANK1_HUMAN
θ value	4.00176e-32 (rank : 10)	NC score	0.876961 (rank : 24)
Query Neighborhood Hits	471	Target Neighborhood Hits	416	Shared Neighborhood Hits	304
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

DAPK1_MOUSE
θ value	8.91499e-32 (rank : 11)	NC score	0.408151 (rank : 258)
Query Neighborhood Hits	471	Target Neighborhood Hits	1138	Shared Neighborhood Hits	295
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DAPK1_HUMAN
θ value	1.52067e-31 (rank : 12)	NC score	0.399856 (rank : 259)
Query Neighborhood Hits	471	Target Neighborhood Hits	1130	Shared Neighborhood Hits	292
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

RIPK4_HUMAN
θ value	9.8567e-31 (rank : 13)	NC score	0.564975 (rank : 209)
Query Neighborhood Hits	471	Target Neighborhood Hits	1094	Shared Neighborhood Hits	300
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

ANR44_HUMAN
θ value	1.85889e-29 (rank : 14)	NC score	0.889196 (rank : 13)
Query Neighborhood Hits	471	Target Neighborhood Hits	318	Shared Neighborhood Hits	303
SwissProt Accessions	Q8N8A2, Q6P480, Q86VL5, Q8IZ72, Q9UFA4	Gene names	ANKRD44
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 44.

TNKS1_HUMAN
θ value	2.68423e-28 (rank : 15)	NC score	0.878239 (rank : 18)
Query Neighborhood Hits	471	Target Neighborhood Hits	477	Shared Neighborhood Hits	305
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

ANR52_MOUSE
θ value	5.97985e-28 (rank : 16)	NC score	0.879227 (rank : 15)
Query Neighborhood Hits	471	Target Neighborhood Hits	318	Shared Neighborhood Hits	300
SwissProt Accessions	Q8BTI7	Gene names	Ankrd52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

TNKS2_HUMAN
θ value	1.33217e-27 (rank : 17)	NC score	0.877932 (rank : 20)
Query Neighborhood Hits	471	Target Neighborhood Hits	361	Shared Neighborhood Hits	305
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

ANKK1_HUMAN
θ value	2.96777e-27 (rank : 18)	NC score	0.571756 (rank : 207)
Query Neighborhood Hits	471	Target Neighborhood Hits	1075	Shared Neighborhood Hits	297
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

ANR52_HUMAN
θ value	8.63488e-27 (rank : 19)	NC score	0.878082 (rank : 19)
Query Neighborhood Hits	471	Target Neighborhood Hits	322	Shared Neighborhood Hits	300
SwissProt Accessions	Q8NB46	Gene names	ANKRD52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

ANKK1_MOUSE
θ value	9.54697e-26 (rank : 20)	NC score	0.556957 (rank : 212)
Query Neighborhood Hits	471	Target Neighborhood Hits	1072	Shared Neighborhood Hits	296
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

ANKR6_HUMAN
θ value	1.24688e-25 (rank : 21)	NC score	0.901904 (rank : 5)
Query Neighborhood Hits	471	Target Neighborhood Hits	439	Shared Neighborhood Hits	296
SwissProt Accessions	Q9Y2G4, Q9NU24, Q9UFQ9	Gene names	ANKRD6, KIAA0957
Domain Architecture
Description	Ankyrin repeat domain-containing protein 6.

ANR50_HUMAN
θ value	2.77775e-25 (rank : 22)	NC score	0.893787 (rank : 10)
Query Neighborhood Hits	471	Target Neighborhood Hits	361	Shared Neighborhood Hits	300
SwissProt Accessions	Q9ULJ7, Q6N064, Q6ZSE6	Gene names	ANKRD50, KIAA1223
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 50.

ASB3_MOUSE
θ value	3.62785e-25 (rank : 23)	NC score	0.878324 (rank : 16)
Query Neighborhood Hits	471	Target Neighborhood Hits	316	Shared Neighborhood Hits	292
SwissProt Accessions	Q9WV72	Gene names	Asb3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

ASB3_HUMAN
θ value	3.39556e-23 (rank : 24)	NC score	0.880063 (rank : 14)
Query Neighborhood Hits	471	Target Neighborhood Hits	316	Shared Neighborhood Hits	297
SwissProt Accessions	Q9Y575, Q9NVZ2	Gene names	ASB3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

TNI3K_MOUSE
θ value	7.56453e-23 (rank : 25)	NC score	0.442751 (rank : 251)
Query Neighborhood Hits	471	Target Neighborhood Hits	1079	Shared Neighborhood Hits	300
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

CSKI1_MOUSE
θ value	9.87957e-23 (rank : 26)	NC score	0.815560 (rank : 100)
Query Neighborhood Hits	471	Target Neighborhood Hits	1031	Shared Neighborhood Hits	300
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

ASB2_HUMAN
θ value	1.29031e-22 (rank : 27)	NC score	0.873401 (rank : 32)
Query Neighborhood Hits	471	Target Neighborhood Hits	309	Shared Neighborhood Hits	291
SwissProt Accessions	Q96Q27, Q9NSU5, Q9Y567	Gene names	ASB2
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 2 (ASB-2).

ANKS1_HUMAN
θ value	1.6852e-22 (rank : 28)	NC score	0.846178 (rank : 56)
Query Neighborhood Hits	471	Target Neighborhood Hits	438	Shared Neighborhood Hits	298
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

CSKI1_HUMAN
θ value	1.6852e-22 (rank : 29)	NC score	0.817045 (rank : 96)
Query Neighborhood Hits	471	Target Neighborhood Hits	997	Shared Neighborhood Hits	299
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

ASB2_MOUSE
θ value	1.09232e-21 (rank : 30)	NC score	0.868291 (rank : 40)
Query Neighborhood Hits	471	Target Neighborhood Hits	321	Shared Neighborhood Hits	290
SwissProt Accessions	Q8K0L0, Q9CTH4, Q9WV73	Gene names	Asb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 2 (ASB-2).

INVS_HUMAN
θ value	1.09232e-21 (rank : 31)	NC score	0.876722 (rank : 25)
Query Neighborhood Hits	471	Target Neighborhood Hits	455	Shared Neighborhood Hits	291
SwissProt Accessions	Q9Y283, Q5W0T6, Q8IVX8, Q9BRB9, Q9Y488, Q9Y498	Gene names	INVS, INV, NPHP2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning homolog) (Nephrocystin-2).

INVS_MOUSE
θ value	3.17815e-21 (rank : 32)	NC score	0.866831 (rank : 42)
Query Neighborhood Hits	471	Target Neighborhood Hits	609	Shared Neighborhood Hits	294
SwissProt Accessions	O89019, O88849	Gene names	Invs, Inv, Nphp2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning protein) (Nephrocystin-2).

CSKI2_HUMAN
θ value	5.42112e-21 (rank : 33)	NC score	0.820794 (rank : 91)
Query Neighborhood Hits	471	Target Neighborhood Hits	747	Shared Neighborhood Hits	300
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

PSD10_MOUSE
θ value	7.0802e-21 (rank : 34)	NC score	0.899186 (rank : 7)
Query Neighborhood Hits	471	Target Neighborhood Hits	293	Shared Neighborhood Hits	288
SwissProt Accessions	Q9Z2X2, Q9D7N8	Gene names	Psmd10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

ANR42_MOUSE
θ value	9.24701e-21 (rank : 35)	NC score	0.873640 (rank : 31)
Query Neighborhood Hits	471	Target Neighborhood Hits	334	Shared Neighborhood Hits	285
SwissProt Accessions	Q3V096, Q8BX55, Q8BZT3, Q8C0T6, Q8C0X5	Gene names	Ankrd42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

PSD10_HUMAN
θ value	9.24701e-21 (rank : 36)	NC score	0.899893 (rank : 6)
Query Neighborhood Hits	471	Target Neighborhood Hits	301	Shared Neighborhood Hits	293
SwissProt Accessions	O75832	Gene names	PSMD10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

ANKR2_MOUSE
θ value	1.2077e-20 (rank : 37)	NC score	0.878287 (rank : 17)
Query Neighborhood Hits	471	Target Neighborhood Hits	312	Shared Neighborhood Hits	289
SwissProt Accessions	Q9WV06	Gene names	Ankrd2, Arpp
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (mArpp).

CTTB2_HUMAN
θ value	1.2077e-20 (rank : 38)	NC score	0.747133 (rank : 150)
Query Neighborhood Hits	471	Target Neighborhood Hits	1061	Shared Neighborhood Hits	310
SwissProt Accessions	Q8WZ74, O43389, Q7LG11, Q9C0A5	Gene names	CTTNBP2, C7orf8, CORTBP2, KIAA1758
Domain Architecture	No domain graphic available
Description	Cortactin-binding protein 2 (CortBP2).

ANKR2_HUMAN
θ value	3.51386e-20 (rank : 39)	NC score	0.877313 (rank : 23)
Query Neighborhood Hits	471	Target Neighborhood Hits	321	Shared Neighborhood Hits	289
SwissProt Accessions	Q9GZV1, Q5T456, Q8WUD7	Gene names	ANKRD2, ARPP
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (hArpp).

CSKI2_MOUSE
θ value	3.51386e-20 (rank : 40)	NC score	0.821515 (rank : 90)
Query Neighborhood Hits	471	Target Neighborhood Hits	812	Shared Neighborhood Hits	301
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

RN5A_MOUSE
θ value	4.58923e-20 (rank : 41)	NC score	0.774758 (rank : 137)
Query Neighborhood Hits	471	Target Neighborhood Hits	899	Shared Neighborhood Hits	295
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

RAI14_MOUSE
θ value	5.99374e-20 (rank : 42)	NC score	0.620867 (rank : 193)
Query Neighborhood Hits	471	Target Neighborhood Hits	1505	Shared Neighborhood Hits	320
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

ANR29_HUMAN
θ value	1.02238e-19 (rank : 43)	NC score	0.895757 (rank : 9)
Query Neighborhood Hits	471	Target Neighborhood Hits	294	Shared Neighborhood Hits	290
SwissProt Accessions	Q8N6D5, Q6ZWE8, Q96LU9	Gene names	ANKRD29
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 29.

ANR16_HUMAN
θ value	1.33526e-19 (rank : 44)	NC score	0.897114 (rank : 8)
Query Neighborhood Hits	471	Target Neighborhood Hits	286	Shared Neighborhood Hits	280
SwissProt Accessions	Q6P6B7, Q9NT01	Gene names	ANKRD16
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 16.

BCL3_MOUSE
θ value	1.33526e-19 (rank : 45)	NC score	0.873985 (rank : 30)
Query Neighborhood Hits	471	Target Neighborhood Hits	388	Shared Neighborhood Hits	287
SwissProt Accessions	Q9Z2F6	Gene names	Bcl3
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 3-encoded protein homolog (Protein Bcl-3).

RAI14_HUMAN
θ value	1.33526e-19 (rank : 46)	NC score	0.658242 (rank : 188)
Query Neighborhood Hits	471	Target Neighborhood Hits	1367	Shared Neighborhood Hits	324
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

TRPA1_MOUSE
θ value	2.27762e-19 (rank : 47)	NC score	0.862475 (rank : 46)
Query Neighborhood Hits	471	Target Neighborhood Hits	343	Shared Neighborhood Hits	296
SwissProt Accessions	Q8BLA8	Gene names	Trpa1, Anktm1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1).

ANKS1_MOUSE
θ value	5.07402e-19 (rank : 48)	NC score	0.830377 (rank : 77)
Query Neighborhood Hits	471	Target Neighborhood Hits	453	Shared Neighborhood Hits	296
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

PA2G6_MOUSE
θ value	6.62687e-19 (rank : 49)	NC score	0.865588 (rank : 44)
Query Neighborhood Hits	471	Target Neighborhood Hits	293	Shared Neighborhood Hits	290
SwissProt Accessions	P97819, Q99LA9, Q9JK61	Gene names	Pla2g6
Domain Architecture
Description	85 kDa calcium-independent phospholipase A2 (EC 3.1.1.4) (iPLA2) (CaI- PLA2) (Group VI phospholipase A2) (GVI PLA2).

ZDH17_HUMAN
θ value	6.62687e-19 (rank : 50)	NC score	0.776572 (rank : 135)
Query Neighborhood Hits	471	Target Neighborhood Hits	334	Shared Neighborhood Hits	282
SwissProt Accessions	Q8IUH5, O75407, Q7Z2I0, Q86W89, Q86YK0, Q9P088, Q9UPZ8	Gene names	ZDHHC17, HIP14, HIP3, KIAA0946
Domain Architecture
Description	Palmitoyltransferase ZDHHC17 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 17) (DHHC-17) (Huntingtin-interacting protein 14) (Huntingtin-interacting protein 3) (Huntingtin-interacting protein HYPH) (Putative NF-kappa-B-activating protein 205) (Putative MAPK- activating protein PM11).

BCL3_HUMAN
θ value	8.65492e-19 (rank : 51)	NC score	0.877414 (rank : 21)
Query Neighborhood Hits	471	Target Neighborhood Hits	324	Shared Neighborhood Hits	288
SwissProt Accessions	P20749	Gene names	BCL3
Domain Architecture
Description	B-cell lymphoma 3-encoded protein (Protein Bcl-3).

NFKB1_HUMAN
θ value	8.65492e-19 (rank : 52)	NC score	0.765901 (rank : 142)
Query Neighborhood Hits	471	Target Neighborhood Hits	306	Shared Neighborhood Hits	278
SwissProt Accessions	P19838, Q68D84, Q86V43, Q8N4X7, Q9NZC0	Gene names	NFKB1
Domain Architecture
Description	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) [Contains: Nuclear factor NF-kappa-B p50 subunit].

ANFY1_MOUSE
θ value	1.47631e-18 (rank : 53)	NC score	0.786965 (rank : 132)
Query Neighborhood Hits	471	Target Neighborhood Hits	480	Shared Neighborhood Hits	303
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ZDH17_MOUSE
θ value	1.47631e-18 (rank : 54)	NC score	0.771467 (rank : 139)
Query Neighborhood Hits	471	Target Neighborhood Hits	328	Shared Neighborhood Hits	276
SwissProt Accessions	Q80TN5, Q8BJ08, Q8BYQ2, Q8BYQ6	Gene names	Zdhhc17, Hip14, Kiaa0946
Domain Architecture
Description	Palmitoyltransferase ZDHHC17 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 17) (DHHC-17) (Huntingtin-interacting protein 14).

TRPA1_HUMAN
θ value	2.5182e-18 (rank : 55)	NC score	0.858436 (rank : 50)
Query Neighborhood Hits	471	Target Neighborhood Hits	339	Shared Neighborhood Hits	296
SwissProt Accessions	O75762	Gene names	TRPA1, ANKTM1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation sensitive-protein p120).

ZDH13_MOUSE
θ value	3.28887e-18 (rank : 56)	NC score	0.768881 (rank : 140)
Query Neighborhood Hits	471	Target Neighborhood Hits	329	Shared Neighborhood Hits	282
SwissProt Accessions	Q9CWU2, Q3UK32, Q3UKV1	Gene names	Zdhhc13, Hip14l
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC13 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 13) (DHHC-13) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein).

NFKB2_HUMAN
θ value	4.29542e-18 (rank : 57)	NC score	0.760935 (rank : 148)
Query Neighborhood Hits	471	Target Neighborhood Hits	325	Shared Neighborhood Hits	283
SwissProt Accessions	Q00653, Q04860, Q9BU75, Q9H471, Q9H472	Gene names	NFKB2, LYT10
Domain Architecture
Description	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10) (Oncogene Lyt-10) (Lyt10) [Contains: Nuclear factor NF-kappa-B p52 subunit].

ZDH13_HUMAN
θ value	5.60996e-18 (rank : 58)	NC score	0.771588 (rank : 138)
Query Neighborhood Hits	471	Target Neighborhood Hits	322	Shared Neighborhood Hits	279
SwissProt Accessions	Q8IUH4, Q7Z2D3, Q86VK2, Q9NV30, Q9NV99	Gene names	ZDHHC13, HIP14L, HIP3RP
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC13 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 13) (DHHC-13) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein) (Huntingtin- interacting protein HIP3RP) (Putative NF-kappa-B-activating protein 209) (Putative MAPK-activating protein PM03).

NFKB1_MOUSE
θ value	7.32683e-18 (rank : 59)	NC score	0.763678 (rank : 143)
Query Neighborhood Hits	471	Target Neighborhood Hits	300	Shared Neighborhood Hits	270
SwissProt Accessions	P25799, Q3TZE8, Q3V2V6, Q6TDG8, Q75ZL1, Q80Y21, Q8C712	Gene names	Nfkb1
Domain Architecture
Description	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) (NF-kappa-B1 p84/NF-kappa-B1 p98) [Contains: Nuclear factor NF- kappa-B p50 subunit].

PA2G6_HUMAN
θ value	7.32683e-18 (rank : 60)	NC score	0.861178 (rank : 47)
Query Neighborhood Hits	471	Target Neighborhood Hits	284	Shared Neighborhood Hits	281
SwissProt Accessions	O60733, O75645, Q8N452, Q9UG29, Q9UIT0, Q9Y671	Gene names	PLA2G6, IPLA2
Domain Architecture
Description	85 kDa calcium-independent phospholipase A2 (EC 3.1.1.4) (iPLA2) (CaI- PLA2) (Group VI phospholipase A2) (GVI PLA2).

RN5A_HUMAN
θ value	7.32683e-18 (rank : 61)	NC score	0.823481 (rank : 87)
Query Neighborhood Hits	471	Target Neighborhood Hits	608	Shared Neighborhood Hits	284
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

ANR18_HUMAN
θ value	1.63225e-17 (rank : 62)	NC score	0.655148 (rank : 189)
Query Neighborhood Hits	471	Target Neighborhood Hits	1106	Shared Neighborhood Hits	289
SwissProt Accessions	Q8IVF6, Q7Z468	Gene names	ANKRD18A, KIAA2015
Domain Architecture
Description	Ankyrin repeat domain-containing protein 18A.

ANR35_HUMAN
θ value	2.13179e-17 (rank : 63)	NC score	0.803907 (rank : 120)
Query Neighborhood Hits	471	Target Neighborhood Hits	784	Shared Neighborhood Hits	299
SwissProt Accessions	Q8N283, Q3MJ10, Q96LS3	Gene names	ANKRD35
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 35.

ANR42_HUMAN
θ value	2.13179e-17 (rank : 64)	NC score	0.868664 (rank : 39)
Query Neighborhood Hits	471	Target Neighborhood Hits	284	Shared Neighborhood Hits	276
SwissProt Accessions	Q8N9B4, Q49A49	Gene names	ANKRD42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

ANFY1_HUMAN
θ value	2.7842e-17 (rank : 65)	NC score	0.786760 (rank : 133)
Query Neighborhood Hits	471	Target Neighborhood Hits	480	Shared Neighborhood Hits	294
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

NFKB2_MOUSE
θ value	2.7842e-17 (rank : 66)	NC score	0.746229 (rank : 152)
Query Neighborhood Hits	471	Target Neighborhood Hits	326	Shared Neighborhood Hits	279
SwissProt Accessions	Q9WTK5	Gene names	Nfkb2
Domain Architecture
Description	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) [Contains: Nuclear factor NF-kappa-B p52 subunit].

ASB10_MOUSE
θ value	4.74913e-17 (rank : 67)	NC score	0.868205 (rank : 41)
Query Neighborhood Hits	471	Target Neighborhood Hits	301	Shared Neighborhood Hits	286
SwissProt Accessions	Q91ZT7	Gene names	Asb10
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

IKBA_HUMAN
θ value	4.74913e-17 (rank : 68)	NC score	0.853520 (rank : 53)
Query Neighborhood Hits	471	Target Neighborhood Hits	280	Shared Neighborhood Hits	278
SwissProt Accessions	P25963	Gene names	NFKBIA, IKBA, MAD3, NFKBI
Domain Architecture
Description	NF-kappa-B inhibitor alpha (Major histocompatibility complex enhancer- binding protein MAD3) (I-kappa-B-alpha) (IkappaBalpha) (IKB-alpha).

TNI3K_HUMAN
θ value	4.74913e-17 (rank : 69)	NC score	0.443914 (rank : 249)
Query Neighborhood Hits	471	Target Neighborhood Hits	1084	Shared Neighborhood Hits	299
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

ANKR7_HUMAN
θ value	6.20254e-17 (rank : 70)	NC score	0.860139 (rank : 48)
Query Neighborhood Hits	471	Target Neighborhood Hits	286	Shared Neighborhood Hits	281
SwissProt Accessions	Q92527, Q96QN1, Q9UDM3	Gene names	ANKRD7
Domain Architecture
Description	Ankyrin repeat domain-containing protein 7 (Testis-specific protein TSA806).

ASB7_HUMAN
θ value	6.20254e-17 (rank : 71)	NC score	0.876111 (rank : 28)
Query Neighborhood Hits	471	Target Neighborhood Hits	296	Shared Neighborhood Hits	283
SwissProt Accessions	Q9H672, Q7Z4S3	Gene names	ASB7
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 7 (ASB-7).

ASB7_MOUSE
θ value	6.20254e-17 (rank : 72)	NC score	0.876277 (rank : 27)
Query Neighborhood Hits	471	Target Neighborhood Hits	296	Shared Neighborhood Hits	283
SwissProt Accessions	Q91ZU0	Gene names	Asb7
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 7 (ASB-7).

A20A1_HUMAN
θ value	8.10077e-17 (rank : 73)	NC score	0.704656 (rank : 171)
Query Neighborhood Hits	471	Target Neighborhood Hits	698	Shared Neighborhood Hits	280
SwissProt Accessions	Q5TYW2, Q9H0H6	Gene names	ANKRD20A1, ANKRD20A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A1.

EHMT2_MOUSE
θ value	8.10077e-17 (rank : 74)	NC score	0.789382 (rank : 130)
Query Neighborhood Hits	471	Target Neighborhood Hits	750	Shared Neighborhood Hits	301
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

A20A3_HUMAN
θ value	1.38178e-16 (rank : 75)	NC score	0.705887 (rank : 169)
Query Neighborhood Hits	471	Target Neighborhood Hits	692	Shared Neighborhood Hits	281
SwissProt Accessions	Q5VUR7	Gene names	ANKRD20A3
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A3.

A20A4_HUMAN
θ value	1.38178e-16 (rank : 76)	NC score	0.701007 (rank : 174)
Query Neighborhood Hits	471	Target Neighborhood Hits	710	Shared Neighborhood Hits	282
SwissProt Accessions	Q5SQ80	Gene names	ANKRD20A4
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A4.

EHMT2_HUMAN
θ value	1.38178e-16 (rank : 77)	NC score	0.805274 (rank : 117)
Query Neighborhood Hits	471	Target Neighborhood Hits	498	Shared Neighborhood Hits	297
SwissProt Accessions	Q96KQ7, Q14349, Q6PK06, Q96MH5, Q96QD0, Q9UQL8, Q9Y331	Gene names	EHMT2, BAT8, G9A, NG36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

ANR19_HUMAN
θ value	1.80466e-16 (rank : 78)	NC score	0.815262 (rank : 101)
Query Neighborhood Hits	471	Target Neighborhood Hits	276	Shared Neighborhood Hits	274
SwissProt Accessions	Q9H560	Gene names	ANKRD19
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 19.

ANR21_HUMAN
θ value	2.35696e-16 (rank : 79)	NC score	0.763410 (rank : 144)
Query Neighborhood Hits	471	Target Neighborhood Hits	864	Shared Neighborhood Hits	295
SwissProt Accessions	Q86YR6	Gene names	ANKRD21, POTE
Domain Architecture
Description	Ankyrin repeat domain-containing protein 21 (Protein POTE) (Prostate, ovary, testis-expressed protein).

EHMT1_HUMAN
θ value	3.07829e-16 (rank : 80)	NC score	0.813394 (rank : 105)
Query Neighborhood Hits	471	Target Neighborhood Hits	417	Shared Neighborhood Hits	296
SwissProt Accessions	Q9H9B1, Q8TCN7, Q96F53, Q96JF1, Q96KH4	Gene names	EHMT1, EUHMTASE1, KIAA1876
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a- like protein 1) (GLP1).

A20A2_HUMAN
θ value	4.02038e-16 (rank : 81)	NC score	0.705377 (rank : 170)
Query Neighborhood Hits	471	Target Neighborhood Hits	716	Shared Neighborhood Hits	281
SwissProt Accessions	Q4UJ75	Gene names	ANKRD20A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A2.

ANR26_MOUSE
θ value	4.02038e-16 (rank : 82)	NC score	0.487172 (rank : 237)
Query Neighborhood Hits	471	Target Neighborhood Hits	1554	Shared Neighborhood Hits	316
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

ANKR1_MOUSE
θ value	5.25075e-16 (rank : 83)	NC score	0.868751 (rank : 36)
Query Neighborhood Hits	471	Target Neighborhood Hits	316	Shared Neighborhood Hits	289
SwissProt Accessions	Q9CR42, O55014, Q3UIF7, Q3UJ39, Q792Q9	Gene names	Ankrd1, Carp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein).

IKBA_MOUSE
θ value	5.25075e-16 (rank : 84)	NC score	0.843907 (rank : 60)
Query Neighborhood Hits	471	Target Neighborhood Hits	283	Shared Neighborhood Hits	278
SwissProt Accessions	Q9Z1E3, Q80ZX5	Gene names	Nfkbia, Ikba
Domain Architecture	No domain graphic available
Description	NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkappaBalpha) (IKB- alpha).

MYPT1_HUMAN
θ value	5.25075e-16 (rank : 85)	NC score	0.813687 (rank : 103)
Query Neighborhood Hits	471	Target Neighborhood Hits	723	Shared Neighborhood Hits	295
SwissProt Accessions	O14974, Q86WU3, Q8NFR6, Q9BYH0	Gene names	PPP1R12A, MBS, MYPT1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit).

ANKR1_HUMAN
θ value	6.85773e-16 (rank : 86)	NC score	0.868692 (rank : 37)
Query Neighborhood Hits	471	Target Neighborhood Hits	308	Shared Neighborhood Hits	282
SwissProt Accessions	Q15327, Q96LE7	Gene names	ANKRD1, C193, CARP, HA1A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) (Cytokine-inducible nuclear protein) (C-193).

IKBE_MOUSE
θ value	6.85773e-16 (rank : 87)	NC score	0.851676 (rank : 55)
Query Neighborhood Hits	471	Target Neighborhood Hits	308	Shared Neighborhood Hits	280
SwissProt Accessions	O54910, Q3U686, Q9CZZ9, Q9D7U3	Gene names	Nfkbie, Ikbe
Domain Architecture
Description	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKB-E).

MYPT2_HUMAN
θ value	6.85773e-16 (rank : 88)	NC score	0.817590 (rank : 95)
Query Neighborhood Hits	471	Target Neighborhood Hits	707	Shared Neighborhood Hits	292
SwissProt Accessions	O60237, Q8N179, Q9HCB7, Q9HCB8	Gene names	PPP1R12B, MYPT2
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase- targeting subunit 2) (Myosin phosphatase target subunit 2).

POT15_HUMAN
θ value	6.85773e-16 (rank : 89)	NC score	0.762606 (rank : 146)
Query Neighborhood Hits	471	Target Neighborhood Hits	893	Shared Neighborhood Hits	293
SwissProt Accessions	Q6S5H4, Q6NXN7, Q6S5H7	Gene names	POTE15
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 15.

PP16A_MOUSE
θ value	1.16975e-15 (rank : 90)	NC score	0.835885 (rank : 69)
Query Neighborhood Hits	471	Target Neighborhood Hits	318	Shared Neighborhood Hits	283
SwissProt Accessions	Q923M0, Q4V9Z1	Gene names	Ppp1r16a, Mypt3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase targeting subunit 3).

ANKS6_MOUSE
θ value	1.52774e-15 (rank : 91)	NC score	0.845226 (rank : 58)
Query Neighborhood Hits	471	Target Neighborhood Hits	435	Shared Neighborhood Hits	292
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

MYPT1_MOUSE
θ value	1.52774e-15 (rank : 92)	NC score	0.832597 (rank : 73)
Query Neighborhood Hits	471	Target Neighborhood Hits	539	Shared Neighborhood Hits	292
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

ANKS6_HUMAN
θ value	1.99529e-15 (rank : 93)	NC score	0.845033 (rank : 59)
Query Neighborhood Hits	471	Target Neighborhood Hits	411	Shared Neighborhood Hits	293
SwissProt Accessions	Q68DC2, Q5VSL0, Q5VSL2, Q5VSL3, Q5VSL4, Q68DB8, Q6P2R2, Q8N9L6, Q96D62	Gene names	ANKS6, ANKRD14, SAMD6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6) (Ankyrin repeat domain-containing protein 14).

ASB10_HUMAN
θ value	1.99529e-15 (rank : 94)	NC score	0.868668 (rank : 38)
Query Neighborhood Hits	471	Target Neighborhood Hits	291	Shared Neighborhood Hits	285
SwissProt Accessions	Q8WXI3	Gene names	ASB10
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

IKBE_HUMAN
θ value	3.40345e-15 (rank : 95)	NC score	0.833738 (rank : 71)
Query Neighborhood Hits	471	Target Neighborhood Hits	288	Shared Neighborhood Hits	270
SwissProt Accessions	O00221	Gene names	NFKBIE, IKBE
Domain Architecture
Description	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKBE).

OSBL1_HUMAN
θ value	3.40345e-15 (rank : 96)	NC score	0.682062 (rank : 183)
Query Neighborhood Hits	471	Target Neighborhood Hits	368	Shared Neighborhood Hits	281
SwissProt Accessions	Q9BXW6, Q9BZF5, Q9NW87	Gene names	OSBPL1A, ORP1, OSBP8, OSBPL1
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

OSBL1_MOUSE
θ value	1.29331e-14 (rank : 97)	NC score	0.669585 (rank : 185)
Query Neighborhood Hits	471	Target Neighborhood Hits	336	Shared Neighborhood Hits	283
SwissProt Accessions	Q91XL9, O88318, Q3TH97, Q673L8, Q6DFU6	Gene names	Osbpl1a, Orp1, Orp1a
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

ASB15_HUMAN
θ value	1.68911e-14 (rank : 98)	NC score	0.836075 (rank : 68)
Query Neighborhood Hits	471	Target Neighborhood Hits	305	Shared Neighborhood Hits	282
SwissProt Accessions	Q8WXK1	Gene names	ASB15
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 15 (ASB-15).

ASB8_MOUSE
θ value	2.88119e-14 (rank : 99)	NC score	0.866054 (rank : 43)
Query Neighborhood Hits	471	Target Neighborhood Hits	293	Shared Neighborhood Hits	284
SwissProt Accessions	Q91ZT9, Q8R178	Gene names	Asb8
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 8 (ASB-8).

ANR23_HUMAN
θ value	6.41864e-14 (rank : 100)	NC score	0.869619 (rank : 33)
Query Neighborhood Hits	471	Target Neighborhood Hits	291	Shared Neighborhood Hits	286
SwissProt Accessions	Q86SG2, Q711K7, Q8NAJ7	Gene names	ANKRD23, DARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein) (Muscle ankyrin repeat protein 3).

ASB8_HUMAN
θ value	6.41864e-14 (rank : 101)	NC score	0.864038 (rank : 45)
Query Neighborhood Hits	471	Target Neighborhood Hits	294	Shared Neighborhood Hits	287
SwissProt Accessions	Q9H765, Q547Q2	Gene names	ASB8
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 8 (ASB-8).

NOTC1_HUMAN
θ value	6.41864e-14 (rank : 102)	NC score	0.418067 (rank : 253)
Query Neighborhood Hits	471	Target Neighborhood Hits	906	Shared Neighborhood Hits	289
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

POTE8_HUMAN
θ value	8.38298e-14 (rank : 103)	NC score	0.812610 (rank : 107)
Query Neighborhood Hits	471	Target Neighborhood Hits	337	Shared Neighborhood Hits	288
SwissProt Accessions	Q6S8J7, Q6S8J6	Gene names	POTE8
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 8.

FANK1_HUMAN
θ value	1.09485e-13 (rank : 104)	NC score	0.877365 (rank : 22)
Query Neighborhood Hits	471	Target Neighborhood Hits	326	Shared Neighborhood Hits	286
SwissProt Accessions	Q8TC84, Q6UXY9, Q6X7T6	Gene names	FANK1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains protein 1.

SHAN1_HUMAN
θ value	1.09485e-13 (rank : 105)	NC score	0.709802 (rank : 166)
Query Neighborhood Hits	471	Target Neighborhood Hits	1041	Shared Neighborhood Hits	280
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

ASB15_MOUSE
θ value	1.86753e-13 (rank : 106)	NC score	0.824009 (rank : 85)
Query Neighborhood Hits	471	Target Neighborhood Hits	292	Shared Neighborhood Hits	274
SwissProt Accessions	Q8VHS6	Gene names	Asb15
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 15 (ASB-15).

AN30A_HUMAN
θ value	2.43908e-13 (rank : 107)	NC score	0.609479 (rank : 197)
Query Neighborhood Hits	471	Target Neighborhood Hits	1119	Shared Neighborhood Hits	294
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).

ASB14_MOUSE
θ value	2.43908e-13 (rank : 108)	NC score	0.825579 (rank : 82)
Query Neighborhood Hits	471	Target Neighborhood Hits	293	Shared Neighborhood Hits	276
SwissProt Accessions	Q8VHS7	Gene names	Asb14
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 14 (ASB-14).

PP16B_HUMAN
θ value	2.43908e-13 (rank : 109)	NC score	0.825809 (rank : 81)
Query Neighborhood Hits	471	Target Neighborhood Hits	307	Shared Neighborhood Hits	281
SwissProt Accessions	Q96T49, O94912, Q9NQG4	Gene names	PPP1R16B, ANKRD4, KIAA0823
Domain Architecture
Description	Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta- inhibited membrane-associated protein) (hTIMAP) (CAAX box protein TIMAP) (Ankyrin repeat domain protein 4).

PP16B_MOUSE
θ value	3.18553e-13 (rank : 110)	NC score	0.823532 (rank : 86)
Query Neighborhood Hits	471	Target Neighborhood Hits	302	Shared Neighborhood Hits	281
SwissProt Accessions	Q8VHQ3	Gene names	Ppp1r16b
Domain Architecture
Description	Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta- inhibited membrane-associated protein) (CAAX box protein TIMAP).

UACA_HUMAN
θ value	3.18553e-13 (rank : 111)	NC score	0.518071 (rank : 225)
Query Neighborhood Hits	471	Target Neighborhood Hits	1622	Shared Neighborhood Hits	321
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

ANR23_MOUSE
θ value	4.16044e-13 (rank : 112)	NC score	0.868790 (rank : 35)
Query Neighborhood Hits	471	Target Neighborhood Hits	296	Shared Neighborhood Hits	286
SwissProt Accessions	Q812A3	Gene names	Ankrd23, Darp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein).

FANK1_MOUSE
θ value	4.16044e-13 (rank : 113)	NC score	0.874599 (rank : 29)
Query Neighborhood Hits	471	Target Neighborhood Hits	325	Shared Neighborhood Hits	282
SwissProt Accessions	Q9DAM9, Q9CUA7	Gene names	Fank1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains 1 protein (Germ cell- specific gene 1 protein) (GSG1).

PP16A_HUMAN
θ value	4.16044e-13 (rank : 114)	NC score	0.828240 (rank : 78)
Query Neighborhood Hits	471	Target Neighborhood Hits	340	Shared Neighborhood Hits	278
SwissProt Accessions	Q96I34	Gene names	PPP1R16A, MYPT3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase- targeting subunit 3).

UACA_MOUSE
θ value	4.16044e-13 (rank : 115)	NC score	0.491756 (rank : 235)
Query Neighborhood Hits	471	Target Neighborhood Hits	1620	Shared Neighborhood Hits	317
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

ASB13_MOUSE
θ value	7.09661e-13 (rank : 116)	NC score	0.853618 (rank : 52)
Query Neighborhood Hits	471	Target Neighborhood Hits	293	Shared Neighborhood Hits	283
SwissProt Accessions	Q8VBX0	Gene names	Asb13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 13 (ASB-13).

ASZ1_HUMAN
θ value	7.09661e-13 (rank : 117)	NC score	0.831403 (rank : 74)
Query Neighborhood Hits	471	Target Neighborhood Hits	341	Shared Neighborhood Hits	281
SwissProt Accessions	Q8WWH4	Gene names	ASZ1, GASZ
Domain Architecture
Description	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).

ANKS3_MOUSE
θ value	9.26847e-13 (rank : 118)	NC score	0.840644 (rank : 63)
Query Neighborhood Hits	471	Target Neighborhood Hits	355	Shared Neighborhood Hits	278
SwissProt Accessions	Q9CZK6, Q6ZPF6, Q80X46	Gene names	Anks3, Kiaa1977
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 3.

ANRA2_HUMAN
θ value	9.26847e-13 (rank : 119)	NC score	0.825251 (rank : 83)
Query Neighborhood Hits	471	Target Neighborhood Hits	288	Shared Neighborhood Hits	278
SwissProt Accessions	Q9H9E1	Gene names	ANKRA2, ANKRA
Domain Architecture
Description	Ankyrin repeat family A protein 2 (RFXANK-like 2).

AN36B_HUMAN
θ value	1.2105e-12 (rank : 120)	NC score	0.833356 (rank : 72)
Query Neighborhood Hits	471	Target Neighborhood Hits	294	Shared Neighborhood Hits	287
SwissProt Accessions	Q8N2N9, Q6IPR0	Gene names	ANKRD36B
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 36B.

ANKS3_HUMAN
θ value	2.0648e-12 (rank : 121)	NC score	0.838908 (rank : 66)
Query Neighborhood Hits	471	Target Neighborhood Hits	355	Shared Neighborhood Hits	279
SwissProt Accessions	Q6ZW76, Q8TF25	Gene names	ANKS3, KIAA1977
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 3.

ANR26_HUMAN
θ value	2.69671e-12 (rank : 122)	NC score	0.467520 (rank : 240)
Query Neighborhood Hits	471	Target Neighborhood Hits	1614	Shared Neighborhood Hits	324
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

NOTC4_MOUSE
θ value	2.69671e-12 (rank : 123)	NC score	0.463857 (rank : 242)
Query Neighborhood Hits	471	Target Neighborhood Hits	872	Shared Neighborhood Hits	290
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

ASB13_HUMAN
θ value	3.52202e-12 (rank : 124)	NC score	0.852512 (rank : 54)
Query Neighborhood Hits	471	Target Neighborhood Hits	293	Shared Neighborhood Hits	284
SwissProt Accessions	Q8WXK3, Q96EP7, Q9H8Z1	Gene names	ASB13
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 13 (ASB-13).

MPP8_HUMAN
θ value	3.52202e-12 (rank : 125)	NC score	0.686927 (rank : 179)
Query Neighborhood Hits	471	Target Neighborhood Hits	948	Shared Neighborhood Hits	264
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

NOTC2_HUMAN
θ value	4.59992e-12 (rank : 126)	NC score	0.414612 (rank : 256)
Query Neighborhood Hits	471	Target Neighborhood Hits	1113	Shared Neighborhood Hits	292
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

NOTC2_MOUSE
θ value	4.59992e-12 (rank : 127)	NC score	0.412311 (rank : 257)
Query Neighborhood Hits	471	Target Neighborhood Hits	1069	Shared Neighborhood Hits	289
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

ANR39_HUMAN
θ value	1.02475e-11 (rank : 128)	NC score	0.859846 (rank : 49)
Query Neighborhood Hits	471	Target Neighborhood Hits	285	Shared Neighborhood Hits	283
SwissProt Accessions	Q53RE8, Q59FU2, Q8N5X5, Q9P0S5	Gene names	ANKRD39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ANR39_MOUSE
θ value	1.02475e-11 (rank : 129)	NC score	0.856595 (rank : 51)
Query Neighborhood Hits	471	Target Neighborhood Hits	284	Shared Neighborhood Hits	283
SwissProt Accessions	Q9D2X0	Gene names	Ankrd39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ANRA2_MOUSE
θ value	1.02475e-11 (rank : 130)	NC score	0.822590 (rank : 88)
Query Neighborhood Hits	471	Target Neighborhood Hits	287	Shared Neighborhood Hits	278
SwissProt Accessions	Q99PE2	Gene names	Ankra2, Ankra
Domain Architecture
Description	Ankyrin repeat family A protein 2 (RFXANK-like 2).

NOTC4_HUMAN
θ value	2.98157e-11 (rank : 131)	NC score	0.457633 (rank : 246)
Query Neighborhood Hits	471	Target Neighborhood Hits	905	Shared Neighborhood Hits	296
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

ANR12_HUMAN
θ value	3.89403e-11 (rank : 132)	NC score	0.710325 (rank : 165)
Query Neighborhood Hits	471	Target Neighborhood Hits	1081	Shared Neighborhood Hits	291
SwissProt Accessions	Q6UB98, O94951, Q658K1, Q6QMF7, Q9H231, Q9H784	Gene names	ANKRD12, ANCO2, KIAA0874
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein).

GABP3_MOUSE
θ value	3.89403e-11 (rank : 133)	NC score	0.845969 (rank : 57)
Query Neighborhood Hits	471	Target Neighborhood Hits	330	Shared Neighborhood Hits	279
SwissProt Accessions	P81069	Gene names	Gabpb2
Domain Architecture	No domain graphic available
Description	GA-binding protein beta-2-1 chain (GABP subunit beta-2-1) (GABPB2-1).

ASB5_HUMAN
θ value	5.08577e-11 (rank : 134)	NC score	0.809678 (rank : 111)
Query Neighborhood Hits	471	Target Neighborhood Hits	283	Shared Neighborhood Hits	271
SwissProt Accessions	Q8WWX0	Gene names	ASB5
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 5 (ASB-5).

ASB9_HUMAN
θ value	5.08577e-11 (rank : 135)	NC score	0.816752 (rank : 97)
Query Neighborhood Hits	471	Target Neighborhood Hits	267	Shared Neighborhood Hits	257
SwissProt Accessions	Q96DX5, Q9NWS5, Q9Y4T3	Gene names	ASB9
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 9 (ASB-9).

CDN2C_MOUSE
θ value	1.133e-10 (rank : 136)	NC score	0.840198 (rank : 64)
Query Neighborhood Hits	471	Target Neighborhood Hits	270	Shared Neighborhood Hits	267
SwissProt Accessions	Q60772	Gene names	Cdkn2c
Domain Architecture
Description	Cyclin-dependent kinase 6 inhibitor (p18-INK6) (Cyclin-dependent kinase 4 inhibitor C) (p18-INK4c).

IKBB_MOUSE
θ value	1.133e-10 (rank : 137)	NC score	0.816436 (rank : 98)
Query Neighborhood Hits	471	Target Neighborhood Hits	284	Shared Neighborhood Hits	281
SwissProt Accessions	Q60778, Q9D6L5	Gene names	Nfkbib, Ikbb
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B).

CDN2C_HUMAN
θ value	1.47974e-10 (rank : 138)	NC score	0.840086 (rank : 65)
Query Neighborhood Hits	471	Target Neighborhood Hits	262	Shared Neighborhood Hits	262
SwissProt Accessions	P42773, Q8TB83	Gene names	CDKN2C, CDKN6
Domain Architecture
Description	Cyclin-dependent kinase 6 inhibitor (p18-INK6) (Cyclin-dependent kinase 4 inhibitor C) (p18-INK4c).

CDN2D_HUMAN
θ value	1.47974e-10 (rank : 139)	NC score	0.827623 (rank : 80)
Query Neighborhood Hits	471	Target Neighborhood Hits	268	Shared Neighborhood Hits	267
SwissProt Accessions	P55273, Q13102, Q6FGE9	Gene names	CDKN2D
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

ASB11_MOUSE
θ value	1.9326e-10 (rank : 140)	NC score	0.811707 (rank : 109)
Query Neighborhood Hits	471	Target Neighborhood Hits	271	Shared Neighborhood Hits	258
SwissProt Accessions	Q9CQ31, Q3UJ13, Q9D0V1	Gene names	Asb11
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 11 (ASB-11).

GABP2_HUMAN
θ value	1.9326e-10 (rank : 141)	NC score	0.842189 (rank : 62)
Query Neighborhood Hits	471	Target Neighborhood Hits	454	Shared Neighborhood Hits	288
SwissProt Accessions	Q06547, Q06545, Q12940, Q12941, Q12942, Q8IYD0	Gene names	GABPB2, E4TF1B, GABPB, GABPB1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1) (Transcription factor E4TF1-53) (Transcription factor E4TF1-47) (Nuclear respiratory factor 2).

HERC2_HUMAN
θ value	1.9326e-10 (rank : 142)	NC score	0.102342 (rank : 348)
Query Neighborhood Hits	471	Target Neighborhood Hits	163	Shared Neighborhood Hits	26
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

ANR11_HUMAN
θ value	3.29651e-10 (rank : 143)	NC score	0.738250 (rank : 159)
Query Neighborhood Hits	471	Target Neighborhood Hits	1289	Shared Neighborhood Hits	289
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

ASZ1_MOUSE
θ value	3.29651e-10 (rank : 144)	NC score	0.828020 (rank : 79)
Query Neighborhood Hits	471	Target Neighborhood Hits	319	Shared Neighborhood Hits	281
SwissProt Accessions	Q8VD46, Q9JKQ7	Gene names	Asz1, Gasz
Domain Architecture
Description	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).

HERC2_MOUSE
θ value	3.29651e-10 (rank : 145)	NC score	0.102397 (rank : 347)
Query Neighborhood Hits	471	Target Neighborhood Hits	167	Shared Neighborhood Hits	28
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

GABP2_MOUSE
θ value	4.30538e-10 (rank : 146)	NC score	0.843465 (rank : 61)
Query Neighborhood Hits	471	Target Neighborhood Hits	429	Shared Neighborhood Hits	288
SwissProt Accessions	Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2	Gene names	Gabpb2, Gabpb, Gabpb1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1).

ANR38_MOUSE
θ value	5.62301e-10 (rank : 147)	NC score	0.664273 (rank : 187)
Query Neighborhood Hits	471	Target Neighborhood Hits	512	Shared Neighborhood Hits	235
SwissProt Accessions	Q6P9J5, Q8BV03	Gene names	Ankrd38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

IKBB_HUMAN
θ value	5.62301e-10 (rank : 148)	NC score	0.811274 (rank : 110)
Query Neighborhood Hits	471	Target Neighborhood Hits	284	Shared Neighborhood Hits	278
SwissProt Accessions	Q15653, Q96BJ7	Gene names	NFKBIB, IKBB, TRIP9
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9).

NOTC1_MOUSE
θ value	5.62301e-10 (rank : 149)	NC score	0.357688 (rank : 268)
Query Neighborhood Hits	471	Target Neighborhood Hits	916	Shared Neighborhood Hits	268
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

NOTC3_HUMAN
θ value	5.62301e-10 (rank : 150)	NC score	0.416607 (rank : 254)
Query Neighborhood Hits	471	Target Neighborhood Hits	1062	Shared Neighborhood Hits	293
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

NOTC3_MOUSE
θ value	5.62301e-10 (rank : 151)	NC score	0.419116 (rank : 252)
Query Neighborhood Hits	471	Target Neighborhood Hits	975	Shared Neighborhood Hits	294
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

ASB11_HUMAN
θ value	9.59137e-10 (rank : 152)	NC score	0.808661 (rank : 113)
Query Neighborhood Hits	471	Target Neighborhood Hits	271	Shared Neighborhood Hits	261
SwissProt Accessions	Q8WXH4, Q3SYC4	Gene names	ASB11
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 11 (ASB-11).

ASB5_MOUSE
θ value	1.63604e-09 (rank : 153)	NC score	0.805003 (rank : 118)
Query Neighborhood Hits	471	Target Neighborhood Hits	266	Shared Neighborhood Hits	259
SwissProt Accessions	Q9D1A4	Gene names	Asb5
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 5 (ASB-5).

ASB4_MOUSE
θ value	2.13673e-09 (rank : 154)	NC score	0.812703 (rank : 106)
Query Neighborhood Hits	471	Target Neighborhood Hits	265	Shared Neighborhood Hits	260
SwissProt Accessions	Q9WV71	Gene names	Asb4
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 4 (ASB-4).

POT14_HUMAN
θ value	2.13673e-09 (rank : 155)	NC score	0.746674 (rank : 151)
Query Neighborhood Hits	471	Target Neighborhood Hits	403	Shared Neighborhood Hits	272
SwissProt Accessions	Q6S5H5, Q6S5H6, Q6S8J2	Gene names	POTE14
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 14.

ILK_MOUSE
θ value	2.79066e-09 (rank : 156)	NC score	0.502806 (rank : 231)
Query Neighborhood Hits	471	Target Neighborhood Hits	858	Shared Neighborhood Hits	283
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

ANR10_HUMAN
θ value	3.64472e-09 (rank : 157)	NC score	0.808968 (rank : 112)
Query Neighborhood Hits	471	Target Neighborhood Hits	289	Shared Neighborhood Hits	267
SwissProt Accessions	Q9NXR5	Gene names	ANKRD10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

ASB16_HUMAN
θ value	3.64472e-09 (rank : 158)	NC score	0.830508 (rank : 76)
Query Neighborhood Hits	471	Target Neighborhood Hits	286	Shared Neighborhood Hits	273
SwissProt Accessions	Q96NS5, Q8WXK0	Gene names	ASB16
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 16 (ASB-16).

CDN2D_MOUSE
θ value	3.64472e-09 (rank : 159)	NC score	0.822036 (rank : 89)
Query Neighborhood Hits	471	Target Neighborhood Hits	267	Shared Neighborhood Hits	266
SwissProt Accessions	Q60773, Q60794	Gene names	Cdkn2d
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

ASB16_MOUSE
θ value	4.76016e-09 (rank : 160)	NC score	0.835252 (rank : 70)
Query Neighborhood Hits	471	Target Neighborhood Hits	306	Shared Neighborhood Hits	284
SwissProt Accessions	Q8VHS5, Q8BYT0	Gene names	Asb16
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 16 (ASB-16).

ILK1_HUMAN
θ value	4.76016e-09 (rank : 161)	NC score	0.504421 (rank : 230)
Query Neighborhood Hits	471	Target Neighborhood Hits	857	Shared Neighborhood Hits	285
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	4.76016e-09 (rank : 162)	NC score	0.522155 (rank : 221)
Query Neighborhood Hits	471	Target Neighborhood Hits	848	Shared Neighborhood Hits	285
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

POT22_HUMAN
θ value	4.76016e-09 (rank : 163)	NC score	0.714388 (rank : 164)
Query Neighborhood Hits	471	Target Neighborhood Hits	266	Shared Neighborhood Hits	257
SwissProt Accessions	Q6S545	Gene names	ACTBL1, POTE22
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 22.

ANR47_MOUSE
θ value	6.21693e-09 (rank : 164)	NC score	0.745189 (rank : 153)
Query Neighborhood Hits	471	Target Neighborhood Hits	350	Shared Neighborhood Hits	260
SwissProt Accessions	Q9Z1P7	Gene names	Ankrd47, D17Ertd288e, Ng28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

ASB4_HUMAN
θ value	6.21693e-09 (rank : 165)	NC score	0.812236 (rank : 108)
Query Neighborhood Hits	471	Target Neighborhood Hits	264	Shared Neighborhood Hits	260
SwissProt Accessions	Q9Y574, O14586	Gene names	ASB4
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 4 (ASB-4).

BARD1_HUMAN
θ value	8.11959e-09 (rank : 166)	NC score	0.806538 (rank : 114)
Query Neighborhood Hits	471	Target Neighborhood Hits	427	Shared Neighborhood Hits	337
SwissProt Accessions	Q99728, O43574	Gene names	BARD1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

OSTF1_MOUSE
θ value	8.11959e-09 (rank : 167)	NC score	0.653727 (rank : 190)
Query Neighborhood Hits	471	Target Neighborhood Hits	467	Shared Neighborhood Hits	256
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

ASB12_HUMAN
θ value	1.06045e-08 (rank : 168)	NC score	0.789008 (rank : 131)
Query Neighborhood Hits	471	Target Neighborhood Hits	263	Shared Neighborhood Hits	263
SwissProt Accessions	Q8WXK4, Q52LK4, Q6ISF9	Gene names	ASB12
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 12 (ASB-12).

ASB9_MOUSE
θ value	1.06045e-08 (rank : 169)	NC score	0.800959 (rank : 123)
Query Neighborhood Hits	471	Target Neighborhood Hits	257	Shared Neighborhood Hits	252
SwissProt Accessions	Q91ZT8, Q9DAF7	Gene names	Asb9
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 9 (ASB-9).

ANR32_MOUSE
θ value	1.38499e-08 (rank : 170)	NC score	0.766571 (rank : 141)
Query Neighborhood Hits	471	Target Neighborhood Hits	285	Shared Neighborhood Hits	262
SwissProt Accessions	Q8R3P9, Q5XK30, Q8BHY5, Q921Y9	Gene names	Ankrd32
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 32.

HECD1_HUMAN
θ value	1.38499e-08 (rank : 171)	NC score	0.617230 (rank : 194)
Query Neighborhood Hits	471	Target Neighborhood Hits	371	Shared Neighborhood Hits	275
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

BARD1_MOUSE
θ value	1.80886e-08 (rank : 172)	NC score	0.806238 (rank : 115)
Query Neighborhood Hits	471	Target Neighborhood Hits	411	Shared Neighborhood Hits	331
SwissProt Accessions	O70445	Gene names	Bard1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

ACBD6_MOUSE
θ value	2.36244e-08 (rank : 173)	NC score	0.803539 (rank : 121)
Query Neighborhood Hits	471	Target Neighborhood Hits	305	Shared Neighborhood Hits	291
SwissProt Accessions	Q9D061, Q3TMN7, Q9DCU4	Gene names	Acbd6
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 6.

AN36A_HUMAN
θ value	2.36244e-08 (rank : 174)	NC score	0.799113 (rank : 124)
Query Neighborhood Hits	471	Target Neighborhood Hits	271	Shared Neighborhood Hits	270
SwissProt Accessions	Q6UX02, Q86X62	Gene names	ANKRD36, ANKRD36A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 36A.

ANR10_MOUSE
θ value	2.36244e-08 (rank : 175)	NC score	0.806015 (rank : 116)
Query Neighborhood Hits	471	Target Neighborhood Hits	273	Shared Neighborhood Hits	265
SwissProt Accessions	Q99LW0	Gene names	Ankrd10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

ANR15_HUMAN
θ value	2.36244e-08 (rank : 176)	NC score	0.739691 (rank : 157)
Query Neighborhood Hits	471	Target Neighborhood Hits	478	Shared Neighborhood Hits	271
SwissProt Accessions	Q14678, Q5W0W0, Q8IY65, Q8WX74	Gene names	ANKRD15, KANK, KIAA0172
Domain Architecture
Description	Ankyrin repeat domain-containing protein 15 (Kidney ankyrin repeat- containing protein).

ANR49_MOUSE
θ value	2.36244e-08 (rank : 177)	NC score	0.837382 (rank : 67)
Query Neighborhood Hits	471	Target Neighborhood Hits	285	Shared Neighborhood Hits	278
SwissProt Accessions	Q8VE42, Q9Z2S1	Gene names	Ankrd49, Fgif, Gbif
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor) (Fetal globin-increasing factor).

ASB1_MOUSE
θ value	3.08544e-08 (rank : 178)	NC score	0.792778 (rank : 129)
Query Neighborhood Hits	471	Target Neighborhood Hits	292	Shared Neighborhood Hits	276
SwissProt Accessions	Q9WV74	Gene names	Asb1
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 1 (ASB-1).

RFXK_HUMAN
θ value	3.08544e-08 (rank : 179)	NC score	0.814497 (rank : 102)
Query Neighborhood Hits	471	Target Neighborhood Hits	282	Shared Neighborhood Hits	267
SwissProt Accessions	O14593, O95839	Gene names	RFXANK, ANKRA1, RFXB
Domain Architecture
Description	DNA-binding protein RFXANK (Regulatory factor X subunit B) (RFX-B) (Ankyrin repeat family A protein 1).

RNF34_MOUSE
θ value	4.0297e-08 (rank : 180)	NC score	0.213154 (rank : 295)
Query Neighborhood Hits	471	Target Neighborhood Hits	160	Shared Neighborhood Hits	77
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

ANKR5_HUMAN
θ value	5.26297e-08 (rank : 181)	NC score	0.818441 (rank : 93)
Query Neighborhood Hits	471	Target Neighborhood Hits	297	Shared Neighborhood Hits	282
SwissProt Accessions	Q9NU02, Q9H6Y9	Gene names	ANKRD5
Domain Architecture
Description	Ankyrin repeat domain-containing protein 5.

ANR38_HUMAN
θ value	5.26297e-08 (rank : 182)	NC score	0.683629 (rank : 182)
Query Neighborhood Hits	471	Target Neighborhood Hits	443	Shared Neighborhood Hits	242
SwissProt Accessions	Q5T7N3, Q6P9A0, Q86T71, Q86VE6, Q8NAX3	Gene names	ANKRD38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

BCOR_HUMAN
θ value	5.26297e-08 (rank : 183)	NC score	0.706117 (rank : 168)
Query Neighborhood Hits	471	Target Neighborhood Hits	609	Shared Neighborhood Hits	279
SwissProt Accessions	Q6W2J9, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2	Gene names	BCOR, KIAA1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

BCOR_MOUSE
θ value	5.26297e-08 (rank : 184)	NC score	0.715324 (rank : 163)
Query Neighborhood Hits	471	Target Neighborhood Hits	521	Shared Neighborhood Hits	277
SwissProt Accessions	Q8CGN4, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3	Gene names	Bcor, Kiaa1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

RNF34_HUMAN
θ value	5.26297e-08 (rank : 185)	NC score	0.212775 (rank : 296)
Query Neighborhood Hits	471	Target Neighborhood Hits	153	Shared Neighborhood Hits	78
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

ANR22_HUMAN
θ value	6.87365e-08 (rank : 186)	NC score	0.824403 (rank : 84)
Query Neighborhood Hits	471	Target Neighborhood Hits	243	Shared Neighborhood Hits	243
SwissProt Accessions	Q5VYY1, Q8WU06	Gene names	ANKRD22
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 22.

ANR32_HUMAN
θ value	6.87365e-08 (rank : 187)	NC score	0.775579 (rank : 136)
Query Neighborhood Hits	471	Target Neighborhood Hits	270	Shared Neighborhood Hits	262
SwissProt Accessions	Q9BQI6	Gene names	ANKRD32
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 32.

BIRC2_HUMAN
θ value	8.97725e-08 (rank : 188)	NC score	0.175636 (rank : 301)
Query Neighborhood Hits	471	Target Neighborhood Hits	142	Shared Neighborhood Hits	89
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

OSTF1_HUMAN
θ value	8.97725e-08 (rank : 189)	NC score	0.635217 (rank : 191)
Query Neighborhood Hits	471	Target Neighborhood Hits	466	Shared Neighborhood Hits	254
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

ACBD6_HUMAN
θ value	1.17247e-07 (rank : 190)	NC score	0.797698 (rank : 125)
Query Neighborhood Hits	471	Target Neighborhood Hits	304	Shared Neighborhood Hits	287
SwissProt Accessions	Q9BR61	Gene names	ACBD6
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 6.

ANR47_HUMAN
θ value	1.17247e-07 (rank : 191)	NC score	0.721365 (rank : 161)
Query Neighborhood Hits	471	Target Neighborhood Hits	369	Shared Neighborhood Hits	253
SwissProt Accessions	Q6NY19, Q6NZI1, Q6ZQR3, Q8IUV2	Gene names	ANKRD47
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

ASB6_HUMAN
θ value	1.17247e-07 (rank : 192)	NC score	0.763304 (rank : 145)
Query Neighborhood Hits	471	Target Neighborhood Hits	256	Shared Neighborhood Hits	249
SwissProt Accessions	Q9NWX5	Gene names	ASB6
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 6 (ASB-6).

ASB6_MOUSE
θ value	1.17247e-07 (rank : 193)	NC score	0.761448 (rank : 147)
Query Neighborhood Hits	471	Target Neighborhood Hits	264	Shared Neighborhood Hits	247
SwissProt Accessions	Q91ZU1, Q8VEC6	Gene names	Asb6
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 6 (ASB-6).

ANR25_MOUSE
θ value	1.53129e-07 (rank : 194)	NC score	0.687398 (rank : 178)
Query Neighborhood Hits	471	Target Neighborhood Hits	398	Shared Neighborhood Hits	257
SwissProt Accessions	Q8BX02, Q8BLD5, Q91Z35	Gene names	Ankrd25
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25.

ANR49_HUMAN
θ value	1.99992e-07 (rank : 195)	NC score	0.831107 (rank : 75)
Query Neighborhood Hits	471	Target Neighborhood Hits	282	Shared Neighborhood Hits	275
SwissProt Accessions	Q8WVL7, Q8NDF2, Q96JE5, Q9NXK7	Gene names	ANKRD49, FGIF
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor).

ASB1_HUMAN
θ value	2.61198e-07 (rank : 196)	NC score	0.794246 (rank : 128)
Query Neighborhood Hits	471	Target Neighborhood Hits	291	Shared Neighborhood Hits	276
SwissProt Accessions	Q9Y576, Q9ULS4	Gene names	ASB1, KIAA1146
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 1 (ASB-1).

BIRC3_HUMAN
θ value	2.61198e-07 (rank : 197)	NC score	0.177827 (rank : 300)
Query Neighborhood Hits	471	Target Neighborhood Hits	133	Shared Neighborhood Hits	86
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).

ANS4B_HUMAN
θ value	3.41135e-07 (rank : 198)	NC score	0.752944 (rank : 149)
Query Neighborhood Hits	471	Target Neighborhood Hits	289	Shared Neighborhood Hits	259
SwissProt Accessions	Q8N8V4	Gene names	ANKS4B, HARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

ANKR5_MOUSE
θ value	5.81887e-07 (rank : 199)	NC score	0.817611 (rank : 94)
Query Neighborhood Hits	471	Target Neighborhood Hits	298	Shared Neighborhood Hits	283
SwissProt Accessions	Q9D2J7	Gene names	Ankrd5
Domain Architecture
Description	Ankyrin repeat domain-containing protein 5.

ANR25_HUMAN
θ value	5.81887e-07 (rank : 200)	NC score	0.697834 (rank : 175)
Query Neighborhood Hits	471	Target Neighborhood Hits	350	Shared Neighborhood Hits	257
SwissProt Accessions	Q63ZY3, Q3KQZ3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210	Gene names	ANKRD25, KIAA1518, SIP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25 (SRC-1-interacting protein) (SRC1-interacting protein).

BIRC2_MOUSE
θ value	5.81887e-07 (rank : 201)	NC score	0.173814 (rank : 306)
Query Neighborhood Hits	471	Target Neighborhood Hits	137	Shared Neighborhood Hits	84
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

MTPN_MOUSE
θ value	5.81887e-07 (rank : 202)	NC score	0.820744 (rank : 92)
Query Neighborhood Hits	471	Target Neighborhood Hits	269	Shared Neighborhood Hits	267
SwissProt Accessions	P62774, P80144, Q543M6, Q9DCN8	Gene names	Mtpn, Gcdp
Domain Architecture	No domain graphic available
Description	Myotrophin (Protein V-1) (Granule cell differentiation protein).

BIRC3_MOUSE
θ value	7.59969e-07 (rank : 203)	NC score	0.175492 (rank : 302)
Query Neighborhood Hits	471	Target Neighborhood Hits	113	Shared Neighborhood Hits	77
SwissProt Accessions	O08863	Gene names	Birc3, Birc2, Iap1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (MIAP1) (MIAP-1).

ASB12_MOUSE
θ value	9.92553e-07 (rank : 204)	NC score	0.780503 (rank : 134)
Query Neighborhood Hits	471	Target Neighborhood Hits	261	Shared Neighborhood Hits	259
SwissProt Accessions	Q9D738	Gene names	Asb12
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 12 (ASB-12).

ASPP1_HUMAN
θ value	1.29631e-06 (rank : 205)	NC score	0.540657 (rank : 216)
Query Neighborhood Hits	471	Target Neighborhood Hits	956	Shared Neighborhood Hits	271
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_MOUSE
θ value	1.29631e-06 (rank : 206)	NC score	0.522796 (rank : 220)
Query Neighborhood Hits	471	Target Neighborhood Hits	1244	Shared Neighborhood Hits	274
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BIRC4_MOUSE
θ value	1.29631e-06 (rank : 207)	NC score	0.163833 (rank : 307)
Query Neighborhood Hits	471	Target Neighborhood Hits	89	Shared Neighborhood Hits	64
SwissProt Accessions	Q60989, O08865	Gene names	Birc4, Aipa, Api3, Miha, Xiap
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3).

MTPN_HUMAN
θ value	1.29631e-06 (rank : 208)	NC score	0.815979 (rank : 99)
Query Neighborhood Hits	471	Target Neighborhood Hits	269	Shared Neighborhood Hits	267
SwissProt Accessions	P58546	Gene names	MTPN
Domain Architecture
Description	Myotrophin (Protein V-1).

BIRC4_HUMAN
θ value	1.69304e-06 (rank : 209)	NC score	0.163747 (rank : 308)
Query Neighborhood Hits	471	Target Neighborhood Hits	89	Shared Neighborhood Hits	64
SwissProt Accessions	P98170, Q9NQ14	Gene names	BIRC4, API3, IAP3, XIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP).

ANS4B_MOUSE
θ value	2.21117e-06 (rank : 210)	NC score	0.738885 (rank : 158)
Query Neighborhood Hits	471	Target Neighborhood Hits	294	Shared Neighborhood Hits	255
SwissProt Accessions	Q8K3X6, Q9D8A5	Gene names	Anks4b, Harp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

BIRC7_HUMAN
θ value	2.21117e-06 (rank : 211)	NC score	0.218830 (rank : 294)
Query Neighborhood Hits	471	Target Neighborhood Hits	185	Shared Neighborhood Hits	107
SwissProt Accessions	Q96CA5, Q9BQV0, Q9H2A8, Q9HAP7	Gene names	BIRC7, KIAP, LIVIN, MLIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 7 (Kidney inhibitor of apoptosis protein) (KIAP) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (Livin).

DDFL1_MOUSE
θ value	2.88788e-06 (rank : 212)	NC score	0.464261 (rank : 241)
Query Neighborhood Hits	471	Target Neighborhood Hits	324	Shared Neighborhood Hits	248
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

LRSM1_MOUSE
θ value	2.88788e-06 (rank : 213)	NC score	0.113651 (rank : 331)
Query Neighborhood Hits	471	Target Neighborhood Hits	874	Shared Neighborhood Hits	94
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

ABTB2_MOUSE
θ value	3.77169e-06 (rank : 214)	NC score	0.577727 (rank : 206)
Query Neighborhood Hits	471	Target Neighborhood Hits	414	Shared Neighborhood Hits	240
SwissProt Accessions	Q7TQI7	Gene names	Abtb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

TEX14_MOUSE
θ value	3.77169e-06 (rank : 215)	NC score	0.397184 (rank : 260)
Query Neighborhood Hits	471	Target Neighborhood Hits	1333	Shared Neighborhood Hits	264
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

CD2A1_MOUSE
θ value	4.92598e-06 (rank : 216)	NC score	0.684165 (rank : 180)
Query Neighborhood Hits	471	Target Neighborhood Hits	206	Shared Neighborhood Hits	201
SwissProt Accessions	P51480, O89088, P97510, P97937, Q6PEA2, Q78E39, Q78E57, Q792X7, Q9QWH6, Q9QWH7, Q9QWH8	Gene names	Cdkn2a, P16ink4a
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 2A, isoforms 1/2 (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4) (p16-INK4a).

LRSM1_HUMAN
θ value	4.92598e-06 (rank : 217)	NC score	0.109518 (rank : 336)
Query Neighborhood Hits	471	Target Neighborhood Hits	1078	Shared Neighborhood Hits	100
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

BIRC8_HUMAN
θ value	6.43352e-06 (rank : 218)	NC score	0.187428 (rank : 299)
Query Neighborhood Hits	471	Target Neighborhood Hits	121	Shared Neighborhood Hits	73
SwissProt Accessions	Q96P09, Q96RW5	Gene names	BIRC8, ILP2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis- like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis).

DGKZ_MOUSE
θ value	8.40245e-06 (rank : 219)	NC score	0.376584 (rank : 265)
Query Neighborhood Hits	471	Target Neighborhood Hits	542	Shared Neighborhood Hits	204
SwissProt Accessions	Q80UP3	Gene names	Dgkz
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

ANKY2_MOUSE
θ value	1.09739e-05 (rank : 220)	NC score	0.718054 (rank : 162)
Query Neighborhood Hits	471	Target Neighborhood Hits	316	Shared Neighborhood Hits	263
SwissProt Accessions	Q3TPE9, Q8BK14, Q8BYW5, Q8R3N4, Q921J1	Gene names	Ankmy2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and MYND domain-containing protein 2.

ASPP2_HUMAN
θ value	1.09739e-05 (rank : 221)	NC score	0.556656 (rank : 213)
Query Neighborhood Hits	471	Target Neighborhood Hits	1156	Shared Neighborhood Hits	285
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

ANKY2_HUMAN
θ value	1.43324e-05 (rank : 222)	NC score	0.741858 (rank : 156)
Query Neighborhood Hits	471	Target Neighborhood Hits	306	Shared Neighborhood Hits	263
SwissProt Accessions	Q8IV38, Q96BL3	Gene names	ANKMY2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and MYND domain-containing protein 2.

DGKZ_HUMAN
θ value	1.43324e-05 (rank : 223)	NC score	0.394828 (rank : 262)
Query Neighborhood Hits	471	Target Neighborhood Hits	551	Shared Neighborhood Hits	219
SwissProt Accessions	Q13574, O00542	Gene names	DGKZ, DAGK6
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

RFFL_HUMAN
θ value	1.43324e-05 (rank : 224)	NC score	0.196824 (rank : 298)
Query Neighborhood Hits	471	Target Neighborhood Hits	175	Shared Neighborhood Hits	76
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

RFFL_MOUSE
θ value	1.43324e-05 (rank : 225)	NC score	0.198692 (rank : 297)
Query Neighborhood Hits	471	Target Neighborhood Hits	145	Shared Neighborhood Hits	74
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RFXK_MOUSE
θ value	1.87187e-05 (rank : 226)	NC score	0.802008 (rank : 122)
Query Neighborhood Hits	471	Target Neighborhood Hits	273	Shared Neighborhood Hits	266
SwissProt Accessions	Q9Z205	Gene names	Rfxank, Rfxb, Tvl1
Domain Architecture
Description	DNA-binding protein RFXANK (Regulatory factor X subunit B) (RFX-B) (Regulatory factor X-associated ankyrin-containing protein) (Ankyrin repeat-containing adapter protein Tvl-1).

RNF8_MOUSE
θ value	1.87187e-05 (rank : 227)	NC score	0.127105 (rank : 320)
Query Neighborhood Hits	471	Target Neighborhood Hits	618	Shared Neighborhood Hits	128
SwissProt Accessions	Q8VC56, Q9JK13	Gene names	Rnf8
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8) (AIP37) (ActA-interacting protein 37) (LaXp180).

SQSTM_MOUSE
θ value	1.87187e-05 (rank : 228)	NC score	0.150746 (rank : 310)
Query Neighborhood Hits	471	Target Neighborhood Hits	82	Shared Neighborhood Hits	22
SwissProt Accessions	Q64337, Q99JM8	Gene names	Sqstm1, A170, STAP
Domain Architecture	No domain graphic available
Description	Sequestosome-1 (Ubiquitin-binding protein p62) (STONE14).

ABTB2_HUMAN
θ value	2.44474e-05 (rank : 229)	NC score	0.582495 (rank : 205)
Query Neighborhood Hits	471	Target Neighborhood Hits	391	Shared Neighborhood Hits	240
SwissProt Accessions	Q8N961, Q6MZW4, Q8NB44	Gene names	ABTB2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

ANR46_HUMAN
θ value	2.44474e-05 (rank : 230)	NC score	0.804824 (rank : 119)
Query Neighborhood Hits	471	Target Neighborhood Hits	281	Shared Neighborhood Hits	276
SwissProt Accessions	Q86W74, Q6P9B7	Gene names	ANKRD46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

KRIT1_HUMAN
θ value	2.44474e-05 (rank : 231)	NC score	0.666648 (rank : 186)
Query Neighborhood Hits	471	Target Neighborhood Hits	258	Shared Neighborhood Hits	222
SwissProt Accessions	O00522, O43894, Q506L6, Q6U276, Q75N19, Q9H180, Q9H264, Q9HAX5	Gene names	KRIT1, CCM1
Domain Architecture
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein).

MYLIP_HUMAN
θ value	2.44474e-05 (rank : 232)	NC score	0.107450 (rank : 337)
Query Neighborhood Hits	471	Target Neighborhood Hits	162	Shared Neighborhood Hits	73
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

SQSTM_HUMAN
θ value	2.44474e-05 (rank : 233)	NC score	0.147566 (rank : 312)
Query Neighborhood Hits	471	Target Neighborhood Hits	61	Shared Neighborhood Hits	19
SwissProt Accessions	Q13501, Q13446, Q9BUV7, Q9BVS6, Q9UEU1	Gene names	SQSTM1, ORCA
Domain Architecture	No domain graphic available
Description	Sequestosome-1 (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (EBI3-associated protein of 60 kDa) (p60) (EBIAP).

NUD12_MOUSE
θ value	3.19293e-05 (rank : 234)	NC score	0.588544 (rank : 200)
Query Neighborhood Hits	471	Target Neighborhood Hits	243	Shared Neighborhood Hits	222
SwissProt Accessions	Q9DCN1, Q6PFA5	Gene names	Nudt12
Domain Architecture	No domain graphic available
Description	Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12).

ANR46_MOUSE
θ value	4.1701e-05 (rank : 235)	NC score	0.797343 (rank : 126)
Query Neighborhood Hits	471	Target Neighborhood Hits	274	Shared Neighborhood Hits	269
SwissProt Accessions	Q8BTZ5, Q1LZK9, Q8BV97	Gene names	Ankrd46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

KRIT1_MOUSE
θ value	4.1701e-05 (rank : 236)	NC score	0.674987 (rank : 184)
Query Neighborhood Hits	471	Target Neighborhood Hits	258	Shared Neighborhood Hits	229
SwissProt Accessions	Q6S5J6, Q6VSV2, Q7TPR8, Q8C9Q6, Q9EPY2, Q9ERH0	Gene names	Krit1, Ccm1
Domain Architecture	No domain graphic available
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog).

TEX14_HUMAN
θ value	4.1701e-05 (rank : 237)	NC score	0.395228 (rank : 261)
Query Neighborhood Hits	471	Target Neighborhood Hits	1103	Shared Neighborhood Hits	246
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TRPV6_HUMAN
θ value	4.1701e-05 (rank : 238)	NC score	0.493715 (rank : 234)
Query Neighborhood Hits	471	Target Neighborhood Hits	262	Shared Neighborhood Hits	232
SwissProt Accessions	Q9H1D0, Q8TDL3, Q8WXR8, Q96LC5, Q9H1D1, Q9H296	Gene names	TRPV6, ECAC2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1) (CaT-like) (CaT-L).

USH1G_HUMAN
θ value	4.1701e-05 (rank : 239)	NC score	0.745036 (rank : 155)
Query Neighborhood Hits	471	Target Neighborhood Hits	267	Shared Neighborhood Hits	259
SwissProt Accessions	Q495M9, Q8N251	Gene names	USH1G, SANS
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein (Scaffold protein containing ankyrin repeats and SAM domain).

USH1G_MOUSE
θ value	4.1701e-05 (rank : 240)	NC score	0.745125 (rank : 154)
Query Neighborhood Hits	471	Target Neighborhood Hits	271	Shared Neighborhood Hits	259
SwissProt Accessions	Q80T11, Q80UG0	Gene names	Ush1g, Sans
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein homolog (Scaffold protein containing ankyrin repeats and SAM domain) (Jackson shaker protein).

ANR33_HUMAN
θ value	5.44631e-05 (rank : 241)	NC score	0.702728 (rank : 173)
Query Neighborhood Hits	471	Target Neighborhood Hits	215	Shared Neighborhood Hits	212
SwissProt Accessions	Q7Z3H0, Q5K619, Q5K621, Q5K622, Q5K623, Q5K624, Q6ZUN0	Gene names	ANKRD33, C12orf7
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

MYLIP_MOUSE
θ value	5.44631e-05 (rank : 242)	NC score	0.093618 (rank : 362)
Query Neighborhood Hits	471	Target Neighborhood Hits	139	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

NUD12_HUMAN
θ value	5.44631e-05 (rank : 243)	NC score	0.561802 (rank : 210)
Query Neighborhood Hits	471	Target Neighborhood Hits	222	Shared Neighborhood Hits	201
SwissProt Accessions	Q9BQG2, Q8TAL7	Gene names	NUDT12
Domain Architecture	No domain graphic available
Description	Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12).

TRPV5_HUMAN
θ value	7.1131e-05 (rank : 244)	NC score	0.494230 (rank : 233)
Query Neighborhood Hits	471	Target Neighborhood Hits	261	Shared Neighborhood Hits	230
SwissProt Accessions	Q9NQA5, Q8NDW5, Q8NDX7, Q8NDX8, Q96PM6	Gene names	TRPV5, ECAC1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Calcium transport protein 2) (CaT2).

TRPV5_MOUSE
θ value	7.1131e-05 (rank : 245)	NC score	0.517583 (rank : 226)
Query Neighborhood Hits	471	Target Neighborhood Hits	278	Shared Neighborhood Hits	252
SwissProt Accessions	P69744	Gene names	Trpv5
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC1) (Calcium transport protein 2) (CaT2).

TRPV6_MOUSE
θ value	7.1131e-05 (rank : 246)	NC score	0.569138 (rank : 208)
Query Neighborhood Hits	471	Target Neighborhood Hits	284	Shared Neighborhood Hits	259
SwissProt Accessions	Q91WD2	Gene names	Trpv6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1).

DDEF2_HUMAN
θ value	0.000121331 (rank : 247)	NC score	0.388066 (rank : 263)
Query Neighborhood Hits	471	Target Neighborhood Hits	599	Shared Neighborhood Hits	235
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	0.000121331 (rank : 248)	NC score	0.385232 (rank : 264)
Query Neighborhood Hits	471	Target Neighborhood Hits	625	Shared Neighborhood Hits	237
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

TRI50_MOUSE
θ value	0.000121331 (rank : 249)	NC score	0.107292 (rank : 338)
Query Neighborhood Hits	471	Target Neighborhood Hits	326	Shared Neighborhood Hits	116
SwissProt Accessions	Q810I2	Gene names	Trim50
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 50.

ZSWM2_HUMAN
θ value	0.000121331 (rank : 250)	NC score	0.121400 (rank : 325)
Query Neighborhood Hits	471	Target Neighborhood Hits	151	Shared Neighborhood Hits	49
SwissProt Accessions	Q8NEG5	Gene names	ZSWIM2
Domain Architecture
Description	Zinc finger SWIM domain-containing protein 2.

AN13A_MOUSE
θ value	0.000158464 (rank : 251)	NC score	0.444139 (rank : 248)
Query Neighborhood Hits	471	Target Neighborhood Hits	226	Shared Neighborhood Hits	216
SwissProt Accessions	Q80UP5, Q2VPQ7, Q6P7F2	Gene names	Ankrd13a, Ankrd13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13A.

TOPRS_HUMAN
θ value	0.000158464 (rank : 252)	NC score	0.110270 (rank : 335)
Query Neighborhood Hits	471	Target Neighborhood Hits	286	Shared Neighborhood Hits	88
SwissProt Accessions	Q9NS56, O43273, Q6P987, Q9NS55, Q9UNR9	Gene names	TOPORS, LUN, TP53BPL
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

TOPRS_MOUSE
θ value	0.000158464 (rank : 253)	NC score	0.110950 (rank : 333)
Query Neighborhood Hits	471	Target Neighborhood Hits	263	Shared Neighborhood Hits	84
SwissProt Accessions	Q80Z37, Q3U5B5, Q3UPZ1, Q3USN3, Q3UZ55, Q8BXP2, Q8CFF5, Q8CGC8, Q920L3	Gene names	Topors
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

CLPB_MOUSE
θ value	0.00035302 (rank : 254)	NC score	0.687696 (rank : 177)
Query Neighborhood Hits	471	Target Neighborhood Hits	289	Shared Neighborhood Hits	249
SwissProt Accessions	Q60649	Gene names	Clpb, Skd3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

DGKI_HUMAN
θ value	0.000461057 (rank : 255)	NC score	0.354364 (rank : 270)
Query Neighborhood Hits	471	Target Neighborhood Hits	609	Shared Neighborhood Hits	219
SwissProt Accessions	O75912, Q9NZ49	Gene names	DGKI
Domain Architecture
Description	Diacylglycerol kinase iota (EC 2.7.1.107) (Diglyceride kinase iota) (DGK-iota) (DAG kinase iota).

AN13B_HUMAN
θ value	0.000602161 (rank : 256)	NC score	0.521484 (rank : 224)
Query Neighborhood Hits	471	Target Neighborhood Hits	265	Shared Neighborhood Hits	252
SwissProt Accessions	Q86YJ7, Q8N7S9	Gene names	ANKRD13B
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13B.

AN13B_MOUSE
θ value	0.000602161 (rank : 257)	NC score	0.521911 (rank : 223)
Query Neighborhood Hits	471	Target Neighborhood Hits	276	Shared Neighborhood Hits	252
SwissProt Accessions	Q5F259, Q6IR40	Gene names	Ankrd13b
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13B.

ANR43_MOUSE
θ value	0.000602161 (rank : 258)	NC score	0.610474 (rank : 196)
Query Neighborhood Hits	471	Target Neighborhood Hits	214	Shared Neighborhood Hits	203
SwissProt Accessions	Q8BLS7	Gene names	Ankrd43
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 43.

CGRF1_MOUSE
θ value	0.000602161 (rank : 259)	NC score	0.154439 (rank : 309)
Query Neighborhood Hits	471	Target Neighborhood Hits	47	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BMJ7, Q3U3F1, Q8CI24	Gene names	Cgrrf1, Cgr19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

ZSWM2_MOUSE
θ value	0.000602161 (rank : 260)	NC score	0.104663 (rank : 343)
Query Neighborhood Hits	471	Target Neighborhood Hits	132	Shared Neighborhood Hits	43
SwissProt Accessions	Q9D9X6	Gene names	Zswim2
Domain Architecture
Description	Zinc finger SWIM domain-containing protein 2.

ANR33_MOUSE
θ value	0.000786445 (rank : 261)	NC score	0.706684 (rank : 167)
Query Neighborhood Hits	471	Target Neighborhood Hits	225	Shared Neighborhood Hits	222
SwissProt Accessions	Q8BXP5, Q8BXP4, Q8R1Z1	Gene names	Ankrd33
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

CT086_HUMAN
θ value	0.000786445 (rank : 262)	NC score	0.796289 (rank : 127)
Query Neighborhood Hits	471	Target Neighborhood Hits	277	Shared Neighborhood Hits	272
SwissProt Accessions	Q9BZ19, Q4VXE6	Gene names	C20orf86
Domain Architecture
Description	Putative uncharacterized protein C20orf86.

TRPV3_MOUSE
θ value	0.000786445 (rank : 263)	NC score	0.270557 (rank : 283)
Query Neighborhood Hits	471	Target Neighborhood Hits	188	Shared Neighborhood Hits	136
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

ANR37_MOUSE
θ value	0.00102713 (rank : 264)	NC score	0.683982 (rank : 181)
Query Neighborhood Hits	471	Target Neighborhood Hits	237	Shared Neighborhood Hits	235
SwissProt Accessions	Q569N2, Q8CHS0	Gene names	Ankrd37
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37.

ANR41_HUMAN
θ value	0.00102713 (rank : 265)	NC score	0.733885 (rank : 160)
Query Neighborhood Hits	471	Target Neighborhood Hits	332	Shared Neighborhood Hits	256
SwissProt Accessions	Q8NAG6, Q8N8J8	Gene names	ANKRD41
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 41.

CENB5_HUMAN
θ value	0.00102713 (rank : 266)	NC score	0.530898 (rank : 218)
Query Neighborhood Hits	471	Target Neighborhood Hits	395	Shared Neighborhood Hits	261
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CGRF1_HUMAN
θ value	0.00102713 (rank : 267)	NC score	0.150537 (rank : 311)
Query Neighborhood Hits	471	Target Neighborhood Hits	51	Shared Neighborhood Hits	38
SwissProt Accessions	Q99675, Q96BX2	Gene names	CGRRF1, CGR19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

CLPB_HUMAN
θ value	0.00102713 (rank : 268)	NC score	0.598905 (rank : 198)
Query Neighborhood Hits	471	Target Neighborhood Hits	265	Shared Neighborhood Hits	238
SwissProt Accessions	Q9H078, Q8ND11, Q9H8Y0	Gene names	CLPB, SKD3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

CLR59_HUMAN
θ value	0.00102713 (rank : 269)	NC score	0.319965 (rank : 275)
Query Neighborhood Hits	471	Target Neighborhood Hits	163	Shared Neighborhood Hits	142
SwissProt Accessions	Q96DZ5, Q8WWL1, Q96C99, Q9UFT7	Gene names	CLIPR59
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 170-related 59 kDa protein (CLIPR-59) (CLIP-170-related 59 kDa protein).

DDFL1_HUMAN
θ value	0.00102713 (rank : 270)	NC score	0.374760 (rank : 266)
Query Neighborhood Hits	471	Target Neighborhood Hits	353	Shared Neighborhood Hits	227
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

ANR43_HUMAN
θ value	0.00134147 (rank : 271)	NC score	0.616929 (rank : 195)
Query Neighborhood Hits	471	Target Neighborhood Hits	209	Shared Neighborhood Hits	200
SwissProt Accessions	Q2M3V2, Q8NAE7	Gene names	ANKRD43
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 43.

CENG2_MOUSE
θ value	0.00134147 (rank : 272)	NC score	0.339896 (rank : 273)
Query Neighborhood Hits	471	Target Neighborhood Hits	463	Shared Neighborhood Hits	251
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

IASPP_HUMAN
θ value	0.00134147 (rank : 273)	NC score	0.545525 (rank : 215)
Query Neighborhood Hits	471	Target Neighborhood Hits	688	Shared Neighborhood Hits	259
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

TRIM6_MOUSE
θ value	0.00134147 (rank : 274)	NC score	0.095673 (rank : 354)
Query Neighborhood Hits	471	Target Neighborhood Hits	451	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BGE7, Q99PQ6	Gene names	Trim6
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 6.

AN13A_HUMAN
θ value	0.00175202 (rank : 275)	NC score	0.462476 (rank : 244)
Query Neighborhood Hits	471	Target Neighborhood Hits	243	Shared Neighborhood Hits	223
SwissProt Accessions	Q8IZ07, O60736	Gene names	ANKRD13A, ANKRD13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13A (Protein KE03).

IKBL_HUMAN
θ value	0.00175202 (rank : 276)	NC score	0.368293 (rank : 267)
Query Neighborhood Hits	471	Target Neighborhood Hits	168	Shared Neighborhood Hits	140
SwissProt Accessions	Q9UBC1, Q14625, Q9UBX4	Gene names	NFKBIL1, IKBL
Domain Architecture
Description	NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like) (I- kappa-B-like) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1).

RNF26_HUMAN
θ value	0.00175202 (rank : 277)	NC score	0.173986 (rank : 305)
Query Neighborhood Hits	471	Target Neighborhood Hits	95	Shared Neighborhood Hits	66
SwissProt Accessions	Q9BY78	Gene names	RNF26
Domain Architecture	No domain graphic available
Description	RING finger protein 26.

TRI31_HUMAN
θ value	0.00175202 (rank : 278)	NC score	0.115926 (rank : 329)
Query Neighborhood Hits	471	Target Neighborhood Hits	299	Shared Neighborhood Hits	107
SwissProt Accessions	Q9BZY9, Q53H52, Q5RI37, Q5SRJ7, Q5SRJ8, Q5SS28, Q96AK4, Q96AP8, Q99579, Q9BZY8	Gene names	TRIM31, C6orf13, RNF
Domain Architecture
Description	Tripartite motif-containing protein 31.

TRI39_HUMAN
θ value	0.00175202 (rank : 279)	NC score	0.090235 (rank : 375)
Query Neighborhood Hits	471	Target Neighborhood Hits	693	Shared Neighborhood Hits	120
SwissProt Accessions	Q9HCM9, Q76BL3, Q8IYT9, Q96IB6	Gene names	TRIM39, RNF23, TFP
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

TRI39_MOUSE
θ value	0.00175202 (rank : 280)	NC score	0.092118 (rank : 371)
Query Neighborhood Hits	471	Target Neighborhood Hits	691	Shared Neighborhood Hits	117
SwissProt Accessions	Q9ESN2, Q8BPR5, Q8K0F7	Gene names	Trim39, Rnf23, Tfp
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

GLSL_MOUSE
θ value	0.00228821 (rank : 281)	NC score	0.513799 (rank : 228)
Query Neighborhood Hits	471	Target Neighborhood Hits	212	Shared Neighborhood Hits	203
SwissProt Accessions	Q571F8	Gene names	Gls2, Kiaa4146
Domain Architecture	No domain graphic available
Description	Glutaminase liver isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (L-glutaminase).

LRRK1_MOUSE
θ value	0.00228821 (rank : 282)	NC score	0.093828 (rank : 359)
Query Neighborhood Hits	471	Target Neighborhood Hits	1267	Shared Neighborhood Hits	124
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

TRI50_HUMAN
θ value	0.00228821 (rank : 283)	NC score	0.102260 (rank : 349)
Query Neighborhood Hits	471	Target Neighborhood Hits	294	Shared Neighborhood Hits	108
SwissProt Accessions	Q86XT4, Q86XT3	Gene names	TRIM50, TRIM50A
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 50.

GLSK_HUMAN
θ value	0.00298849 (rank : 284)	NC score	0.474972 (rank : 239)
Query Neighborhood Hits	471	Target Neighborhood Hits	204	Shared Neighborhood Hits	190
SwissProt Accessions	O94925, Q9UL05, Q9UL06, Q9UL07, Q9UN40	Gene names	GLS, GLS1, KIAA0838
Domain Architecture
Description	Glutaminase kidney isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (K-glutaminase).

GLSL_HUMAN
θ value	0.00298849 (rank : 285)	NC score	0.523563 (rank : 219)
Query Neighborhood Hits	471	Target Neighborhood Hits	211	Shared Neighborhood Hits	202
SwissProt Accessions	Q9UI32, Q9NYY2, Q9UI31	Gene names	GLS2, GA
Domain Architecture
Description	Glutaminase liver isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (L-glutaminase).

RN141_HUMAN
θ value	0.00298849 (rank : 286)	NC score	0.121742 (rank : 324)
Query Neighborhood Hits	471	Target Neighborhood Hits	199	Shared Neighborhood Hits	88
SwissProt Accessions	Q8WVD5, Q9NZB4	Gene names	RNF141, ZNF230
Domain Architecture	No domain graphic available
Description	RING finger protein 141 (Zinc finger protein 230).

TRIM5_HUMAN
θ value	0.00298849 (rank : 287)	NC score	0.097565 (rank : 352)
Query Neighborhood Hits	471	Target Neighborhood Hits	424	Shared Neighborhood Hits	105
SwissProt Accessions	Q9C035, Q8WU46, Q96SR5, Q9C031, Q9C032, Q9C033, Q9C034	Gene names	TRIM5, RNF88
Domain Architecture
Description	Tripartite motif-containing protein 5 (EC 6.3.2.-) (RING finger protein 88).

CENB2_HUMAN
θ value	0.00390308 (rank : 288)	NC score	0.514371 (rank : 227)
Query Neighborhood Hits	471	Target Neighborhood Hits	425	Shared Neighborhood Hits	251
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENG2_HUMAN
θ value	0.00390308 (rank : 289)	NC score	0.341882 (rank : 271)
Query Neighborhood Hits	471	Target Neighborhood Hits	471	Shared Neighborhood Hits	254
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

IKBL_MOUSE
θ value	0.00390308 (rank : 290)	NC score	0.357485 (rank : 269)
Query Neighborhood Hits	471	Target Neighborhood Hits	196	Shared Neighborhood Hits	139
SwissProt Accessions	O88995, Q91X16, Q9R1Y3	Gene names	Nfkbil1, Ikbl
Domain Architecture
Description	NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like) (I- kappa-B-like) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1).

RN141_MOUSE
θ value	0.00390308 (rank : 291)	NC score	0.120448 (rank : 326)
Query Neighborhood Hits	471	Target Neighborhood Hits	200	Shared Neighborhood Hits	87
SwissProt Accessions	Q99MB7, Q9D040, Q9D5C4, Q9D9L0	Gene names	Rnf141, Znf230
Domain Architecture	No domain graphic available
Description	RING finger protein 141 (Zinc finger protein 230).

RSNL2_HUMAN
θ value	0.00390308 (rank : 292)	NC score	0.261413 (rank : 286)
Query Neighborhood Hits	471	Target Neighborhood Hits	136	Shared Neighborhood Hits	114
SwissProt Accessions	Q8N3C7, Q7Z4U3, Q96BR7, Q96MA5, Q9H7C0	Gene names	RSNL2
Domain Architecture	No domain graphic available
Description	Restin-like protein 2.

ANR40_MOUSE
θ value	0.00509761 (rank : 293)	NC score	0.583280 (rank : 204)
Query Neighborhood Hits	471	Target Neighborhood Hits	228	Shared Neighborhood Hits	203
SwissProt Accessions	Q5SUE8, Q8R595, Q9CU71	Gene names	Ankrd40
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 40.

DTNA_MOUSE
θ value	0.00509761 (rank : 294)	NC score	0.089695 (rank : 377)
Query Neighborhood Hits	471	Target Neighborhood Hits	264	Shared Neighborhood Hits	28
SwissProt Accessions	Q9D2N4, P97319, Q61498, Q61499, Q9QZZ5, Q9WUL9, Q9WUM0	Gene names	Dtna, Dtn
Domain Architecture
Description	Dystrobrevin alpha (Alpha-dystrobrevin).

TRI60_HUMAN
θ value	0.00509761 (rank : 295)	NC score	0.094661 (rank : 356)
Query Neighborhood Hits	471	Target Neighborhood Hits	357	Shared Neighborhood Hits	117
SwissProt Accessions	Q495X7, Q8NA35	Gene names	TRIM60, RNF129
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 60 (RING finger protein 129).

UTRO_HUMAN
θ value	0.00509761 (rank : 296)	NC score	0.052398 (rank : 490)
Query Neighborhood Hits	471	Target Neighborhood Hits	960	Shared Neighborhood Hits	47
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

ANR37_HUMAN
θ value	0.00665767 (rank : 297)	NC score	0.703504 (rank : 172)
Query Neighborhood Hits	471	Target Neighborhood Hits	247	Shared Neighborhood Hits	245
SwissProt Accessions	Q7Z713	Gene names	ANKRD37, LPR2BP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37 (Low-density lipoprotein receptor-related protein 2-binding protein) (hLrp2bp).

ANR40_HUMAN
θ value	0.00665767 (rank : 298)	NC score	0.585749 (rank : 202)
Query Neighborhood Hits	471	Target Neighborhood Hits	224	Shared Neighborhood Hits	199
SwissProt Accessions	Q6AI12, Q96E32	Gene names	ANKRD40
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 40.

GIT2_MOUSE
θ value	0.00665767 (rank : 299)	NC score	0.482712 (rank : 238)
Query Neighborhood Hits	471	Target Neighborhood Hits	323	Shared Neighborhood Hits	252
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

IASPP_MOUSE
θ value	0.00665767 (rank : 300)	NC score	0.490046 (rank : 236)
Query Neighborhood Hits	471	Target Neighborhood Hits	1024	Shared Neighborhood Hits	260
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

NEURL_MOUSE
θ value	0.00665767 (rank : 301)	NC score	0.139609 (rank : 313)
Query Neighborhood Hits	471	Target Neighborhood Hits	106	Shared Neighborhood Hits	66
SwissProt Accessions	Q923S6, Q91ZT6, Q9CWF1, Q9QWF1	Gene names	Neurl, Neurl1
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (m-neuralized 1) (m-neu1).

TRIM6_HUMAN
θ value	0.00665767 (rank : 302)	NC score	0.093459 (rank : 365)
Query Neighborhood Hits	471	Target Neighborhood Hits	412	Shared Neighborhood Hits	102
SwissProt Accessions	Q9C030, Q86WZ8, Q9HCR1	Gene names	TRIM6, RNF89
Domain Architecture
Description	Tripartite motif-containing protein 6 (RING finger protein 89).

BRCA1_MOUSE
θ value	0.00869519 (rank : 303)	NC score	0.103168 (rank : 346)
Query Neighborhood Hits	471	Target Neighborhood Hits	436	Shared Neighborhood Hits	105
SwissProt Accessions	P48754, Q60957, Q60983	Gene names	Brca1
Domain Architecture
Description	Breast cancer type 1 susceptibility protein homolog.

CDN2B_MOUSE
θ value	0.00869519 (rank : 304)	NC score	0.633063 (rank : 192)
Query Neighborhood Hits	471	Target Neighborhood Hits	201	Shared Neighborhood Hits	196
SwissProt Accessions	P55271	Gene names	Cdkn2b
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b).

MDM4_HUMAN
θ value	0.00869519 (rank : 305)	NC score	0.084537 (rank : 387)
Query Neighborhood Hits	471	Target Neighborhood Hits	37	Shared Neighborhood Hits	25
SwissProt Accessions	O15151, Q6GS18, Q8IV83	Gene names	MDM4, MDMX
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

NEUL1_HUMAN
θ value	0.00869519 (rank : 306)	NC score	0.138384 (rank : 316)
Query Neighborhood Hits	471	Target Neighborhood Hits	114	Shared Neighborhood Hits	67
SwissProt Accessions	O76050, Q5TDR2, Q5TDR3, Q8TAN0, Q9H463	Gene names	NEURL, NEURL1, RNF67
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (h-neuralized 1) (h-neu) (RING finger protein 67).

TRI30_MOUSE
θ value	0.00869519 (rank : 307)	NC score	0.096937 (rank : 353)
Query Neighborhood Hits	471	Target Neighborhood Hits	434	Shared Neighborhood Hits	100
SwissProt Accessions	P15533, Q99K55, Q99PQ7, Q99PQ8, Q99PQ9	Gene names	Trim30, Rpt-1, Rpt1
Domain Architecture
Description	Tripartite motif-containing protein 30 (Down regulatory protein of interleukin 2 receptor).

CHFR_HUMAN
θ value	0.0113563 (rank : 308)	NC score	0.105376 (rank : 342)
Query Neighborhood Hits	471	Target Neighborhood Hits	255	Shared Neighborhood Hits	94
SwissProt Accessions	Q96EP1, Q96SL3, Q9NRT4, Q9NT32, Q9NVD5	Gene names	CHFR
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

CT012_MOUSE
θ value	0.0113563 (rank : 309)	NC score	0.451820 (rank : 247)
Query Neighborhood Hits	471	Target Neighborhood Hits	229	Shared Neighborhood Hits	179
SwissProt Accessions	Q8C008, Q8C060	Gene names
Domain Architecture	No domain graphic available
Description	Protein C20orf12 homolog.

DTNA_HUMAN
θ value	0.0113563 (rank : 310)	NC score	0.087762 (rank : 378)
Query Neighborhood Hits	471	Target Neighborhood Hits	295	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y4J8, O15332, O15333, O75697, Q13197, Q13198, Q13199, Q13498, Q13499, Q13500	Gene names	DTNA, DRP3
Domain Architecture
Description	Dystrobrevin alpha (Dystrobrevin-alpha) (Dystrophin-related protein 3).

DTNB_HUMAN
θ value	0.0113563 (rank : 311)	NC score	0.086018 (rank : 383)
Query Neighborhood Hits	471	Target Neighborhood Hits	255	Shared Neighborhood Hits	24
SwissProt Accessions	O60941, O43782, O60881, O75538, Q9UE14, Q9UE15, Q9UE16	Gene names	DTNB
Domain Architecture
Description	Dystrobrevin beta (Beta-dystrobrevin) (DTN-B).

MGRN1_HUMAN
θ value	0.0113563 (rank : 312)	NC score	0.120346 (rank : 327)
Query Neighborhood Hits	471	Target Neighborhood Hits	192	Shared Neighborhood Hits	77
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

MGRN1_MOUSE
θ value	0.0113563 (rank : 313)	NC score	0.124384 (rank : 322)
Query Neighborhood Hits	471	Target Neighborhood Hits	149	Shared Neighborhood Hits	78
SwissProt Accessions	Q9D074, Q3U5V9, Q3UDA1, Q6ZQ97, Q8BZM9	Gene names	Mgrn1, Kiaa0544
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1).

AN13C_HUMAN
θ value	0.0148317 (rank : 314)	NC score	0.508241 (rank : 229)
Query Neighborhood Hits	471	Target Neighborhood Hits	241	Shared Neighborhood Hits	236
SwissProt Accessions	Q8N6S4, Q5VYH4, Q5VYH5, Q6PJE4, Q9H0N9	Gene names	ANKRD13C
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13C.

AN13C_MOUSE
θ value	0.0148317 (rank : 315)	NC score	0.498452 (rank : 232)
Query Neighborhood Hits	471	Target Neighborhood Hits	242	Shared Neighborhood Hits	234
SwissProt Accessions	Q3UX43, Q6P1G4	Gene names	Ankrd13c
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13C.

RNF8_HUMAN
θ value	0.0148317 (rank : 316)	NC score	0.110828 (rank : 334)
Query Neighborhood Hits	471	Target Neighborhood Hits	622	Shared Neighborhood Hits	129
SwissProt Accessions	O76064	Gene names	RNF8, KIAA0646
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8).

TRI34_MOUSE
θ value	0.0148317 (rank : 317)	NC score	0.090803 (rank : 374)
Query Neighborhood Hits	471	Target Neighborhood Hits	332	Shared Neighborhood Hits	92
SwissProt Accessions	Q99PP6, Q99PP4, Q99PP5	Gene names	Trim34
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 34.

TRIM4_HUMAN
θ value	0.0148317 (rank : 318)	NC score	0.093942 (rank : 358)
Query Neighborhood Hits	471	Target Neighborhood Hits	321	Shared Neighborhood Hits	103
SwissProt Accessions	Q9C037, Q96F06, Q9C036	Gene names	TRIM4, RNF87
Domain Architecture
Description	Tripartite motif-containing protein 4 (RING finger protein 87).

VPS11_HUMAN
θ value	0.0148317 (rank : 319)	NC score	0.056915 (rank : 472)
Query Neighborhood Hits	471	Target Neighborhood Hits	86	Shared Neighborhood Hits	27
SwissProt Accessions	Q9H270, Q8WY89, Q96EP8, Q9H6D9, Q9HCS6	Gene names	VPS11, RNF108
Domain Architecture
Description	Vacuolar protein sorting-associated protein 11 (hVPS11) (RING finger protein 108).

VPS11_MOUSE
θ value	0.0148317 (rank : 320)	NC score	0.057184 (rank : 469)
Query Neighborhood Hits	471	Target Neighborhood Hits	87	Shared Neighborhood Hits	27
SwissProt Accessions	Q91W86, Q9DBX8	Gene names	Vps11
Domain Architecture
Description	Vacuolar protein sorting-associated protein 11.

ABTB1_MOUSE
θ value	0.0193708 (rank : 321)	NC score	0.308264 (rank : 277)
Query Neighborhood Hits	471	Target Neighborhood Hits	349	Shared Neighborhood Hits	175
SwissProt Accessions	Q99LJ2, Q8C2K7, Q91XU4	Gene names	Abtb1, Bpoz
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 1.

DRP2_HUMAN
θ value	0.0193708 (rank : 322)	NC score	0.065183 (rank : 451)
Query Neighborhood Hits	471	Target Neighborhood Hits	186	Shared Neighborhood Hits	16
SwissProt Accessions	Q13474	Gene names	DRP2
Domain Architecture
Description	Dystrophin-related protein 2.

RO52_HUMAN
θ value	0.0193708 (rank : 323)	NC score	0.106479 (rank : 339)
Query Neighborhood Hits	471	Target Neighborhood Hits	419	Shared Neighborhood Hits	124
SwissProt Accessions	P19474, Q96RF8	Gene names	TRIM21, RNF81, RO52, SSA1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21) (RING finger protein 81).

KRA59_HUMAN
θ value	0.0252991 (rank : 324)	NC score	0.047628 (rank : 506)
Query Neighborhood Hits	471	Target Neighborhood Hits	310	Shared Neighborhood Hits	16
SwissProt Accessions	P26371, Q14564	Gene names	KRTAP5-9, KAP5.9, KRN1, KRTAP5.9, UHSK1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-9 (Keratin-associated protein 5.9) (Ultrahigh sulfur keratin-associated protein 5.9) (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (UHS keratin A) (UHS KerA).

RSNL2_MOUSE
θ value	0.0252991 (rank : 325)	NC score	0.220775 (rank : 292)
Query Neighborhood Hits	471	Target Neighborhood Hits	129	Shared Neighborhood Hits	96
SwissProt Accessions	Q8CI96, Q8BW09, Q921Q4, Q9D2S6	Gene names	Rsnl2
Domain Architecture	No domain graphic available
Description	Restin-like protein 2.

SIAH2_HUMAN
θ value	0.0252991 (rank : 326)	NC score	0.093324 (rank : 366)
Query Neighborhood Hits	471	Target Neighborhood Hits	94	Shared Neighborhood Hits	45
SwissProt Accessions	O43255, O43270	Gene names	SIAH2
Domain Architecture
Description	Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (hSiah2).

SIAH2_MOUSE
θ value	0.0252991 (rank : 327)	NC score	0.094105 (rank : 357)
Query Neighborhood Hits	471	Target Neighborhood Hits	101	Shared Neighborhood Hits	45
SwissProt Accessions	Q06986	Gene names	Siah2
Domain Architecture
Description	Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (mSiah2).

TRI26_MOUSE
θ value	0.0252991 (rank : 328)	NC score	0.117302 (rank : 328)
Query Neighborhood Hits	471	Target Neighborhood Hits	339	Shared Neighborhood Hits	123
SwissProt Accessions	Q99PN3, Q8C9E9, Q8JZT7, Q99PN2	Gene names	Trim26, Znf173
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173).

TRPV3_HUMAN
θ value	0.0252991 (rank : 329)	NC score	0.263071 (rank : 285)
Query Neighborhood Hits	471	Target Neighborhood Hits	198	Shared Neighborhood Hits	147
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

ANKY1_HUMAN
θ value	0.0330416 (rank : 330)	NC score	0.549639 (rank : 214)
Query Neighborhood Hits	471	Target Neighborhood Hits	248	Shared Neighborhood Hits	207
SwissProt Accessions	Q9P2S6, Q8IYX5, Q8NDK5, Q9NX10	Gene names	ANKMY1, TSAL1, ZMYND13
Domain Architecture
Description	Ankyrin repeat and MYND domain-containing protein 1 (Testis-specific ankyrin-like protein 1) (Zinc-finger MYND domain-containing protein 13).

BRCA1_HUMAN
θ value	0.0330416 (rank : 331)	NC score	0.103366 (rank : 345)
Query Neighborhood Hits	471	Target Neighborhood Hits	381	Shared Neighborhood Hits	103
SwissProt Accessions	P38398	Gene names	BRCA1, RNF53
Domain Architecture
Description	Breast cancer type 1 susceptibility protein (RING finger protein 53).

CENB1_HUMAN
θ value	0.0330416 (rank : 332)	NC score	0.522035 (rank : 222)
Query Neighborhood Hits	471	Target Neighborhood Hits	383	Shared Neighborhood Hits	256
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

GIT2_HUMAN
θ value	0.0330416 (rank : 333)	NC score	0.442763 (rank : 250)
Query Neighborhood Hits	471	Target Neighborhood Hits	381	Shared Neighborhood Hits	245
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

LRRK1_HUMAN
θ value	0.0330416 (rank : 334)	NC score	0.067279 (rank : 433)
Query Neighborhood Hits	471	Target Neighborhood Hits	1237	Shared Neighborhood Hits	98
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

NBR1_HUMAN
θ value	0.0330416 (rank : 335)	NC score	0.072853 (rank : 409)
Query Neighborhood Hits	471	Target Neighborhood Hits	105	Shared Neighborhood Hits	23
SwissProt Accessions	Q14596, Q13173, Q15026, Q96GB6, Q9NRF7	Gene names	NBR1, 1A13B, KIAA0049, M17S2
Domain Architecture
Description	Next to BRCA1 gene 1 protein (Neighbor of BRCA1 gene 1 protein) (Membrane component, chromosome 17, surface marker 2) (1A1-3B).

TRI22_HUMAN
θ value	0.0330416 (rank : 336)	NC score	0.093654 (rank : 361)
Query Neighborhood Hits	471	Target Neighborhood Hits	396	Shared Neighborhood Hits	95
SwissProt Accessions	Q8IYM9, Q15521	Gene names	TRIM22, RNF94, STAF50
Domain Architecture
Description	Tripartite motif-containing protein 22 (RING finger protein 94) (50 kDa-stimulated trans-acting factor) (Staf-50).

TRI26_HUMAN
θ value	0.0330416 (rank : 337)	NC score	0.115151 (rank : 330)
Query Neighborhood Hits	471	Target Neighborhood Hits	335	Shared Neighborhood Hits	120
SwissProt Accessions	Q12899	Gene names	TRIM26, RNF95, ZNF173
Domain Architecture
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173) (Acid finger protein) (AFP) (RING finger protein 95).

TRI73_HUMAN
θ value	0.0330416 (rank : 338)	NC score	0.112155 (rank : 332)
Query Neighborhood Hits	471	Target Neighborhood Hits	258	Shared Neighborhood Hits	102
SwissProt Accessions	Q86UV7, Q8N0S3	Gene names	TRIM73, TRIM50B
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 73 (Tripartite motif-containing protein 50B).

ANR45_HUMAN
θ value	0.0431538 (rank : 339)	NC score	0.561437 (rank : 211)
Query Neighborhood Hits	471	Target Neighborhood Hits	201	Shared Neighborhood Hits	185
SwissProt Accessions	Q5TZF3, Q6ZST1	Gene names	ANKRD45
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 45.

DDEF1_MOUSE
θ value	0.0431538 (rank : 340)	NC score	0.297419 (rank : 279)
Query Neighborhood Hits	471	Target Neighborhood Hits	592	Shared Neighborhood Hits	196
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DMD_HUMAN
θ value	0.0431538 (rank : 341)	NC score	0.052400 (rank : 489)
Query Neighborhood Hits	471	Target Neighborhood Hits	1135	Shared Neighborhood Hits	64
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

DMD_MOUSE
θ value	0.0431538 (rank : 342)	NC score	0.051459 (rank : 495)
Query Neighborhood Hits	471	Target Neighborhood Hits	1111	Shared Neighborhood Hits	56
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

DTNB_MOUSE
θ value	0.0431538 (rank : 343)	NC score	0.085489 (rank : 385)
Query Neighborhood Hits	471	Target Neighborhood Hits	263	Shared Neighborhood Hits	25
SwissProt Accessions	O70585, O70563, Q9CTZ1	Gene names	Dtnb
Domain Architecture
Description	Dystrobrevin beta (Beta-dystrobrevin) (DTN-B) (MDTN-B).

EP300_HUMAN
θ value	0.0431538 (rank : 344)	NC score	0.053119 (rank : 486)
Query Neighborhood Hits	471	Target Neighborhood Hits	821	Shared Neighborhood Hits	34
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

MDM4_MOUSE
θ value	0.0431538 (rank : 345)	NC score	0.064116 (rank : 456)
Query Neighborhood Hits	471	Target Neighborhood Hits	36	Shared Neighborhood Hits	19
SwissProt Accessions	O35618	Gene names	Mdm4, Mdmx
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

RING1_HUMAN
θ value	0.0431538 (rank : 346)	NC score	0.098658 (rank : 351)
Query Neighborhood Hits	471	Target Neighborhood Hits	219	Shared Neighborhood Hits	89
SwissProt Accessions	Q06587, Q5JP96, Q5SQW2, Q86V19	Gene names	RING1, RNF1
Domain Architecture
Description	Polycomb complex protein RING1 (RING finger protein 1).

RING1_MOUSE
θ value	0.0431538 (rank : 347)	NC score	0.099649 (rank : 350)
Query Neighborhood Hits	471	Target Neighborhood Hits	220	Shared Neighborhood Hits	91
SwissProt Accessions	O35730, Q3U242, Q3U333, Q4FK33, Q63ZX8, Q921Z8	Gene names	Ring1, Ring1A, Rnf1
Domain Architecture	No domain graphic available
Description	Polycomb complex protein RING1 (RING finger protein 1) (Transcription repressor Ring1A).

SNCAP_HUMAN
θ value	0.0431538 (rank : 348)	NC score	0.696944 (rank : 176)
Query Neighborhood Hits	471	Target Neighborhood Hits	313	Shared Neighborhood Hits	239
SwissProt Accessions	Q9Y6H5	Gene names	SNCAIP
Domain Architecture
Description	Synphilin-1 (Alpha-synuclein-interacting protein).

TRI12_MOUSE
θ value	0.0431538 (rank : 349)	NC score	0.105493 (rank : 341)
Query Neighborhood Hits	471	Target Neighborhood Hits	387	Shared Neighborhood Hits	107
SwissProt Accessions	Q99PQ1, Q9D704	Gene names	Trim12
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 12.

TRI35_HUMAN
θ value	0.0431538 (rank : 350)	NC score	0.093734 (rank : 360)
Query Neighborhood Hits	471	Target Neighborhood Hits	382	Shared Neighborhood Hits	113
SwissProt Accessions	Q9UPQ4, Q86XQ0, Q8WVA4	Gene names	TRIM35, HLS5, KIAA1098
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 35 (Hemopoietic lineage switch protein 5).

ABTB1_HUMAN
θ value	0.0563607 (rank : 351)	NC score	0.266335 (rank : 284)
Query Neighborhood Hits	471	Target Neighborhood Hits	325	Shared Neighborhood Hits	160
SwissProt Accessions	Q969K4, Q6ZNU9, Q71MF1, Q96S62, Q96S63	Gene names	ABTB1, BPOZ
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 1 (Elongation factor 1A-binding protein).

RING2_HUMAN
θ value	0.0563607 (rank : 352)	NC score	0.093501 (rank : 364)
Query Neighborhood Hits	471	Target Neighborhood Hits	201	Shared Neighborhood Hits	85
SwissProt Accessions	Q99496, Q5TEN1, Q5TEN2	Gene names	RNF2, BAP1, DING, HIPI3, RING1B
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein RING2 (EC 6.3.2.-) (RING finger protein 2) (RING finger protein 1B) (RING1b) (RING finger protein BAP-1) (DinG protein) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3).

RING2_MOUSE
θ value	0.0563607 (rank : 353)	NC score	0.093518 (rank : 363)
Query Neighborhood Hits	471	Target Neighborhood Hits	199	Shared Neighborhood Hits	85
SwissProt Accessions	Q9CQJ4, O35699, O35729, Q4FJV5, Q8C1X8	Gene names	Rnf2, DinG, Ring1b
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein RING2 (EC 6.3.2.-) (RING finger protein 2) (RING finger protein 1B) (RING1b).

CD2A1_HUMAN
θ value	0.0736092 (rank : 354)	NC score	0.597824 (rank : 199)
Query Neighborhood Hits	471	Target Neighborhood Hits	196	Shared Neighborhood Hits	190
SwissProt Accessions	P42771, O95440, Q15191, Q5VVJ5, Q96B52, Q9NP05	Gene names	CDKN2A, CDKN2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4) (p16-INK4a) (p16INK4A) (Multiple tumor suppressor 1) (MTS1).

CDN2B_HUMAN
θ value	0.0736092 (rank : 355)	NC score	0.587324 (rank : 201)
Query Neighborhood Hits	471	Target Neighborhood Hits	196	Shared Neighborhood Hits	194
SwissProt Accessions	P42772, Q6FI09	Gene names	CDKN2B, MTS2
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b) (p15INK4B) (Multiple tumor suppressor 2) (MTS2).

TRI74_HUMAN
θ value	0.0736092 (rank : 356)	NC score	0.106205 (rank : 340)
Query Neighborhood Hits	471	Target Neighborhood Hits	249	Shared Neighborhood Hits	97
SwissProt Accessions	Q86UV6	Gene names	TRIM74, TRIM50C
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 74 (Tripartite motif-containing protein 50C).

CBP_HUMAN
θ value	0.0961366 (rank : 357)	NC score	0.051099 (rank : 497)
Query Neighborhood Hits	471	Target Neighborhood Hits	941	Shared Neighborhood Hits	33
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CBP_MOUSE
θ value	0.0961366 (rank : 358)	NC score	0.051504 (rank : 494)
Query Neighborhood Hits	471	Target Neighborhood Hits	1051	Shared Neighborhood Hits	43
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

CT012_HUMAN
θ value	0.0961366 (rank : 359)	NC score	0.415893 (rank : 255)
Query Neighborhood Hits	471	Target Neighborhood Hits	205	Shared Neighborhood Hits	168
SwissProt Accessions	Q9NVP4, Q4F7X1, Q5QPD9, Q5QPE0, Q68DN8, Q6ZMX9, Q96NF0, Q9H1E0, Q9H442	Gene names	C20orf12
Domain Architecture
Description	Protein C20orf12.

TRI34_HUMAN
θ value	0.0961366 (rank : 360)	NC score	0.095213 (rank : 355)
Query Neighborhood Hits	471	Target Neighborhood Hits	416	Shared Neighborhood Hits	98
SwissProt Accessions	Q9BYJ4, Q9C016, Q9HCR0, Q9HCR1, Q9HCR2	Gene names	TRIM34, IFP1, RNF21
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 34 (Interferon-responsive finger protein 1) (RING finger protein 21).

TRPV2_HUMAN
θ value	0.0961366 (rank : 361)	NC score	0.227638 (rank : 290)
Query Neighborhood Hits	471	Target Neighborhood Hits	130	Shared Neighborhood Hits	115
SwissProt Accessions	Q9Y5S1, Q9Y670	Gene names	TRPV2, VRL
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1).

CBLB_MOUSE
θ value	0.125558 (rank : 362)	NC score	0.072794 (rank : 411)
Query Neighborhood Hits	471	Target Neighborhood Hits	277	Shared Neighborhood Hits	95
SwissProt Accessions	Q3TTA7	Gene names	Cblb
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b).

TRI35_MOUSE
θ value	0.125558 (rank : 363)	NC score	0.090003 (rank : 376)
Query Neighborhood Hits	471	Target Neighborhood Hits	465	Shared Neighborhood Hits	109
SwissProt Accessions	Q8C006, Q6ZPY0, Q7TQL7, Q810V7, Q8BVY9, Q8VID4, Q9CW74, Q9D208	Gene names	Trim35, Hls5, Kiaa1098, Mair
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 35 (Macrophage-derived apoptosis- inducing RBCC protein) (Protein MAIR) (Protein Nc8) (Hemopoietic lineage switch protein 5).

ZC3H5_HUMAN
θ value	0.125558 (rank : 364)	NC score	0.052235 (rank : 491)
Query Neighborhood Hits	471	Target Neighborhood Hits	134	Shared Neighborhood Hits	24
SwissProt Accessions	Q9C0B0	Gene names	ZC3H5, KIAA1753, ZC3HDC5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

CBLC_MOUSE
θ value	0.163984 (rank : 365)	NC score	0.073536 (rank : 408)
Query Neighborhood Hits	471	Target Neighborhood Hits	186	Shared Neighborhood Hits	82
SwissProt Accessions	Q80XL1, Q99PB6, Q9D6L2, Q9D7A9	Gene names	Cblc, Cbl3
Domain Architecture	No domain graphic available
Description	Signal transduction protein CBL-C (SH3-binding protein CBL-C) (CBL-3).

CENG1_MOUSE
θ value	0.163984 (rank : 366)	NC score	0.341221 (rank : 272)
Query Neighborhood Hits	471	Target Neighborhood Hits	531	Shared Neighborhood Hits	239
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

PDZD1_MOUSE
θ value	0.163984 (rank : 367)	NC score	0.014134 (rank : 517)
Query Neighborhood Hits	471	Target Neighborhood Hits	191	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

TRI27_HUMAN
θ value	0.163984 (rank : 368)	NC score	0.080225 (rank : 393)
Query Neighborhood Hits	471	Target Neighborhood Hits	273	Shared Neighborhood Hits	104
SwissProt Accessions	P14373, Q5ST26, Q6LA73, Q6NXR9, Q9BZY6, Q9UJL3	Gene names	TRIM27, RFP, RNF76
Domain Architecture
Description	Zinc finger protein RFP (Ret finger protein) (Tripartite motif- containing protein 27) (RING finger protein 76).

TRI27_MOUSE
θ value	0.163984 (rank : 369)	NC score	0.080604 (rank : 392)
Query Neighborhood Hits	471	Target Neighborhood Hits	261	Shared Neighborhood Hits	104
SwissProt Accessions	Q62158, Q62157, Q8C2Q5, Q99LK1	Gene names	Trim27, Rfp
Domain Architecture
Description	Zinc finger protein RFP (Ret finger protein) (Tripartite motif- containing protein 27).

TRI68_HUMAN
θ value	0.163984 (rank : 370)	NC score	0.085632 (rank : 384)
Query Neighborhood Hits	471	Target Neighborhood Hits	267	Shared Neighborhood Hits	94
SwissProt Accessions	Q6AZZ1, Q8WZ70, Q96PF7, Q9H9C2, Q9NW18	Gene names	TRIM68, RNF137, SS56
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 68 (RING finger protein 137) (SSA protein SS-56) (SS-56).

VEZF1_HUMAN
θ value	0.163984 (rank : 371)	NC score	-0.010987 (rank : 533)
Query Neighborhood Hits	471	Target Neighborhood Hits	744	Shared Neighborhood Hits	6
SwissProt Accessions	Q14119	Gene names	VEZF1, DB1, ZNF161
Domain Architecture	No domain graphic available
Description	Vascular endothelial zinc finger 1 (Zinc finger protein 161) (Putative transcription factor DB1).

ASB14_HUMAN
θ value	0.21417 (rank : 372)	NC score	0.536374 (rank : 217)
Query Neighborhood Hits	471	Target Neighborhood Hits	187	Shared Neighborhood Hits	175
SwissProt Accessions	Q8WXK2	Gene names	ASB14
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 14 (ASB-14).

MDM2_MOUSE
θ value	0.21417 (rank : 373)	NC score	0.066393 (rank : 441)
Query Neighborhood Hits	471	Target Neighborhood Hits	77	Shared Neighborhood Hits	31
SwissProt Accessions	P23804, Q61040, Q64330	Gene names	Mdm2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein).

NBR1_MOUSE
θ value	0.21417 (rank : 374)	NC score	0.064685 (rank : 453)
Query Neighborhood Hits	471	Target Neighborhood Hits	116	Shared Neighborhood Hits	18
SwissProt Accessions	P97432, Q9JIH9	Gene names	Nbr1, M17s2
Domain Architecture
Description	Next to BRCA1 gene 1 protein (Neighbor of BRCA1 gene 1 protein) (Membrane component, chromosome 17, surface marker 2).

RKHD1_HUMAN
θ value	0.21417 (rank : 375)	NC score	0.126860 (rank : 321)
Query Neighborhood Hits	471	Target Neighborhood Hits	163	Shared Neighborhood Hits	59
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

RN185_MOUSE
θ value	0.21417 (rank : 376)	NC score	0.092667 (rank : 368)
Query Neighborhood Hits	471	Target Neighborhood Hits	211	Shared Neighborhood Hits	93
SwissProt Accessions	Q91YT2, Q6ZWS3	Gene names	Rnf185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

SIA1A_MOUSE
θ value	0.21417 (rank : 377)	NC score	0.086328 (rank : 380)
Query Neighborhood Hits	471	Target Neighborhood Hits	72	Shared Neighborhood Hits	41
SwissProt Accessions	P61092, Q06984	Gene names	Siah1a
Domain Architecture
Description	Ubiquitin ligase SIAH1A (EC 6.3.2.-) (Seven in absentia homolog 1a) (Siah1a) (Siah-1a) (mSiah-1a).

SIA1B_MOUSE
θ value	0.21417 (rank : 378)	NC score	0.087459 (rank : 379)
Query Neighborhood Hits	471	Target Neighborhood Hits	69	Shared Neighborhood Hits	41
SwissProt Accessions	Q06985, Q7TPV6	Gene names	Siah1b
Domain Architecture
Description	Ubiquitin ligase SIAH1B (EC 6.3.2.-) (Seven in absentia homolog 1b) (Siah1b) (Siah-1b).

SIAH1_HUMAN
θ value	0.21417 (rank : 379)	NC score	0.086303 (rank : 381)
Query Neighborhood Hits	471	Target Neighborhood Hits	72	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IUQ4, O43269, Q92880	Gene names	SIAH1, HUMSIAH
Domain Architecture
Description	Ubiquitin ligase SIAH1 (EC 6.3.2.-) (Seven in absentia homolog 1) (Siah-1) (Siah-1a).

TRI25_MOUSE
θ value	0.21417 (rank : 380)	NC score	0.072842 (rank : 410)
Query Neighborhood Hits	471	Target Neighborhood Hits	446	Shared Neighborhood Hits	110
SwissProt Accessions	Q61510	Gene names	Trim25, Efp, Zfp147, Znf147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp).

CENG1_HUMAN
θ value	0.279714 (rank : 381)	NC score	0.338822 (rank : 274)
Query Neighborhood Hits	471	Target Neighborhood Hits	544	Shared Neighborhood Hits	241
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

TRI15_HUMAN
θ value	0.279714 (rank : 382)	NC score	0.077791 (rank : 400)
Query Neighborhood Hits	471	Target Neighborhood Hits	395	Shared Neighborhood Hits	88
SwissProt Accessions	Q9C019, O95604, Q8IUX9, Q9C018	Gene names	TRIM15, RNF93, ZNF178, ZNFB7
Domain Architecture
Description	Tripartite motif-containing protein 15 (Zinc finger protein B7) (RING finger protein 93) (Zinc finger protein 178).

ZN179_HUMAN
θ value	0.279714 (rank : 383)	NC score	0.083530 (rank : 389)
Query Neighborhood Hits	471	Target Neighborhood Hits	178	Shared Neighborhood Hits	79
SwissProt Accessions	Q9ULX5, O60633	Gene names	ZNF179, BFP, RNF112
Domain Architecture
Description	Zinc finger protein 179 (Brain finger protein) (RING finger protein 112).

ANR45_MOUSE
θ value	0.365318 (rank : 384)	NC score	0.583952 (rank : 203)
Query Neighborhood Hits	471	Target Neighborhood Hits	204	Shared Neighborhood Hits	190
SwissProt Accessions	Q810N6	Gene names	Ankrd45
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 45.

CBLB_HUMAN
θ value	0.365318 (rank : 385)	NC score	0.068140 (rank : 429)
Query Neighborhood Hits	471	Target Neighborhood Hits	261	Shared Neighborhood Hits	93
SwissProt Accessions	Q13191, Q13192, Q13193, Q3LIC0, Q8IVC5	Gene names	CBLB, RNF56
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56).

MDM2_HUMAN
θ value	0.365318 (rank : 386)	NC score	0.069480 (rank : 423)
Query Neighborhood Hits	471	Target Neighborhood Hits	92	Shared Neighborhood Hits	31
SwissProt Accessions	Q00987, Q13226, Q13297, Q13298, Q13299, Q13300, Q13301, Q53XW0, Q71TW9, Q9UGI3, Q9UMT8	Gene names	MDM2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2).

RN185_HUMAN
θ value	0.365318 (rank : 387)	NC score	0.091504 (rank : 372)
Query Neighborhood Hits	471	Target Neighborhood Hits	213	Shared Neighborhood Hits	93
SwissProt Accessions	Q96GF1, Q8N900	Gene names	RNF185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

TRI68_MOUSE
θ value	0.365318 (rank : 388)	NC score	0.085299 (rank : 386)
Query Neighborhood Hits	471	Target Neighborhood Hits	356	Shared Neighborhood Hits	103
SwissProt Accessions	Q8K243	Gene names	Trim68, Rnf137
Domain Architecture	No domain graphic available
Description	Tripartite motif containing protein 68 (Ring finger protein 137).

CHFR_MOUSE
θ value	0.47712 (rank : 389)	NC score	0.092534 (rank : 369)
Query Neighborhood Hits	471	Target Neighborhood Hits	264	Shared Neighborhood Hits	97
SwissProt Accessions	Q810L3, Q8BJZ9, Q8BWH4	Gene names	Chfr
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

TRI52_HUMAN
θ value	0.47712 (rank : 390)	NC score	0.092490 (rank : 370)
Query Neighborhood Hits	471	Target Neighborhood Hits	213	Shared Neighborhood Hits	87
SwissProt Accessions	Q96A61	Gene names	TRIM52, RNF102
Domain Architecture
Description	Tripartite motif-containing protein 52 (RING finger protein 102).

GIT1_HUMAN
θ value	0.62314 (rank : 391)	NC score	0.461665 (rank : 245)
Query Neighborhood Hits	471	Target Neighborhood Hits	336	Shared Neighborhood Hits	245
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

GIT1_MOUSE
θ value	0.62314 (rank : 392)	NC score	0.463097 (rank : 243)
Query Neighborhood Hits	471	Target Neighborhood Hits	341	Shared Neighborhood Hits	246
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

TRI41_HUMAN
θ value	0.62314 (rank : 393)	NC score	0.076146 (rank : 402)
Query Neighborhood Hits	471	Target Neighborhood Hits	349	Shared Neighborhood Hits	83
SwissProt Accessions	Q8WV44, Q5BKT0, Q7L484, Q96Q10, Q9BSL8	Gene names	TRIM41
Domain Architecture
Description	Tripartite motif-containing protein 41.

TRI42_MOUSE
θ value	0.62314 (rank : 394)	NC score	0.048228 (rank : 505)
Query Neighborhood Hits	471	Target Neighborhood Hits	316	Shared Neighborhood Hits	66
SwissProt Accessions	Q9D2H5	Gene names	Trim42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

TRI46_HUMAN
θ value	0.62314 (rank : 395)	NC score	0.058188 (rank : 465)
Query Neighborhood Hits	471	Target Neighborhood Hits	291	Shared Neighborhood Hits	87
SwissProt Accessions	Q7Z4K8, Q6NT17, Q6NT41, Q6ZRL7, Q9H5P2	Gene names	TRIM46, TRIFIC
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 46 (Tripartite, fibronectin type- III and C-terminal SPRY motif protein).

TRI46_MOUSE
θ value	0.62314 (rank : 396)	NC score	0.057519 (rank : 467)
Query Neighborhood Hits	471	Target Neighborhood Hits	287	Shared Neighborhood Hits	86
SwissProt Accessions	Q7TNM2, Q60717, Q6P1I9	Gene names	Trim46, Trific
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 46 (Tripartite, fibronectin type- III and C-terminal SPRY motif protein).

TRI55_HUMAN
θ value	0.62314 (rank : 397)	NC score	0.070774 (rank : 418)
Query Neighborhood Hits	471	Target Neighborhood Hits	292	Shared Neighborhood Hits	77
SwissProt Accessions	Q9BYV6, Q53XX3, Q8IUD9, Q8IUE4, Q96DV2, Q96DV3, Q9BYV5	Gene names	TRIM55, MURF2, RNF29
Domain Architecture
Description	Tripartite motif-containing protein 55 (Muscle-specific RING finger protein 2) (MuRF2) (MURF-2) (RING finger protein 29).

TRPV1_HUMAN
θ value	0.62314 (rank : 398)	NC score	0.242328 (rank : 289)
Query Neighborhood Hits	471	Target Neighborhood Hits	184	Shared Neighborhood Hits	152
SwissProt Accessions	Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22	Gene names	TRPV1, VR1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Capsaicin receptor).

TRPV1_MOUSE
θ value	0.62314 (rank : 399)	NC score	0.253751 (rank : 287)
Query Neighborhood Hits	471	Target Neighborhood Hits	189	Shared Neighborhood Hits	160
SwissProt Accessions	Q704Y3, Q5SSE1, Q5SSE2, Q5SSE4, Q5WPV5, Q68SW0	Gene names	Trpv1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1).

CBL_HUMAN
θ value	0.813845 (rank : 400)	NC score	0.068829 (rank : 427)
Query Neighborhood Hits	471	Target Neighborhood Hits	353	Shared Neighborhood Hits	97
SwissProt Accessions	P22681	Gene names	CBL, CBL2, RNF55
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene) (RING finger protein 55).

CBL_MOUSE
θ value	0.813845 (rank : 401)	NC score	0.067960 (rank : 431)
Query Neighborhood Hits	471	Target Neighborhood Hits	426	Shared Neighborhood Hits	97
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

DTX3_MOUSE
θ value	0.813845 (rank : 402)	NC score	0.071718 (rank : 412)
Query Neighborhood Hits	471	Target Neighborhood Hits	202	Shared Neighborhood Hits	78
SwissProt Accessions	Q80V91, Q9ER06	Gene names	Dtx3
Domain Architecture
Description	Protein deltex-3 (Deltex-3) (Deltex3) (mDTX3).

TRPC1_HUMAN
θ value	0.813845 (rank : 403)	NC score	0.050519 (rank : 499)
Query Neighborhood Hits	471	Target Neighborhood Hits	91	Shared Neighborhood Hits	56
SwissProt Accessions	P48995	Gene names	TRPC1, TRP1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (TRP-1 protein).

CBLC_HUMAN
θ value	1.06291 (rank : 404)	NC score	0.066267 (rank : 444)
Query Neighborhood Hits	471	Target Neighborhood Hits	173	Shared Neighborhood Hits	81
SwissProt Accessions	Q9ULV8, Q8N1E5, Q9Y5Z2, Q9Y5Z3	Gene names	CBLC, CBL3, RNF57
Domain Architecture
Description	Signal transduction protein CBL-C (SH3-binding protein CBL-C) (CBL-3) (RING finger protein 57).

DTX3L_HUMAN
θ value	1.38821 (rank : 405)	NC score	0.057786 (rank : 466)
Query Neighborhood Hits	471	Target Neighborhood Hits	187	Shared Neighborhood Hits	61
SwissProt Accessions	Q8TDB6	Gene names	DTX3L, BBAP
Domain Architecture
Description	Protein deltex 3-like protein (B-lymphoma- and BAL-associated protein) (Rhysin-2) (Rhysin2).

MTF1_HUMAN
θ value	1.38821 (rank : 406)	NC score	-0.012889 (rank : 535)
Query Neighborhood Hits	471	Target Neighborhood Hits	814	Shared Neighborhood Hits	8
SwissProt Accessions	Q14872, Q96CB1	Gene names	MTF1
Domain Architecture	No domain graphic available
Description	Metal-regulatory transcription factor 1 (Transcription factor MTF-1) (MRE-binding transcription factor).

RFWD2_MOUSE
θ value	1.38821 (rank : 407)	NC score	0.042054 (rank : 510)
Query Neighborhood Hits	471	Target Neighborhood Hits	535	Shared Neighborhood Hits	100
SwissProt Accessions	Q9R1A8	Gene names	Rfwd2, Cop1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (mCOP1).

TRI10_HUMAN
θ value	1.38821 (rank : 408)	NC score	0.079347 (rank : 394)
Query Neighborhood Hits	471	Target Neighborhood Hits	315	Shared Neighborhood Hits	94
SwissProt Accessions	Q9UDY6, Q86Z08, Q96QB6, Q9C023, Q9C024	Gene names	TRIM10, RFB30, RNF9
Domain Architecture
Description	Tripartite motif-containing protein 10 (RING finger protein 9) (B30- RING finger protein).

TRPC1_MOUSE
θ value	1.38821 (rank : 409)	NC score	0.044610 (rank : 508)
Query Neighborhood Hits	471	Target Neighborhood Hits	87	Shared Neighborhood Hits	52
SwissProt Accessions	Q61056, O35722	Gene names	Trpc1, Trp1, Trrp1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (Mtrp1) (Trp-related protein 1).

ANKZ1_HUMAN
θ value	1.81305 (rank : 410)	NC score	0.306257 (rank : 278)
Query Neighborhood Hits	471	Target Neighborhood Hits	236	Shared Neighborhood Hits	162
SwissProt Accessions	Q9H8Y5, Q9NVZ4	Gene names	ANKZF1, ZNF744
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1 (Zinc finger protein 744).

BRAP_HUMAN
θ value	1.81305 (rank : 411)	NC score	0.052605 (rank : 488)
Query Neighborhood Hits	471	Target Neighborhood Hits	560	Shared Neighborhood Hits	60
SwissProt Accessions	Q7Z569, O43238, O75341	Gene names	BRAP, RNF52
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (NY-REN-63 antigen).

BRAP_MOUSE
θ value	1.81305 (rank : 412)	NC score	0.044110 (rank : 509)
Query Neighborhood Hits	471	Target Neighborhood Hits	409	Shared Neighborhood Hits	49
SwissProt Accessions	Q99MP8, Q8CC00, Q8CHX1, Q99MP7, Q9CXX8	Gene names	Brap
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP).

BRE1B_HUMAN
θ value	1.81305 (rank : 413)	NC score	0.049610 (rank : 503)
Query Neighborhood Hits	471	Target Neighborhood Hits	1040	Shared Neighborhood Hits	110
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

BRE1B_MOUSE
θ value	1.81305 (rank : 414)	NC score	0.048828 (rank : 504)
Query Neighborhood Hits	471	Target Neighborhood Hits	970	Shared Neighborhood Hits	108
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

FHL1_MOUSE
θ value	1.81305 (rank : 415)	NC score	-0.002357 (rank : 529)
Query Neighborhood Hits	471	Target Neighborhood Hits	462	Shared Neighborhood Hits	6
SwissProt Accessions	P97447, O55181, Q8K318	Gene names	Fhl1
Domain Architecture
Description	Four and a half LIM domains protein 1 (FHL-1) (Skeletal muscle LIM- protein 1) (SLIM 1) (SLIM) (KyoT) (RBP-associated molecule 14-1) (RAM14-1).

TRPC4_HUMAN
θ value	1.81305 (rank : 416)	NC score	0.067151 (rank : 435)
Query Neighborhood Hits	471	Target Neighborhood Hits	140	Shared Neighborhood Hits	80
SwissProt Accessions	Q9UBN4, Q15721, Q9UIB0, Q9UIB1, Q9UIB2	Gene names	TRPC4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (trp-related protein 4) (hTrp-4) (hTrp4).

TRPC4_MOUSE
θ value	1.81305 (rank : 417)	NC score	0.067232 (rank : 434)
Query Neighborhood Hits	471	Target Neighborhood Hits	141	Shared Neighborhood Hits	80
SwissProt Accessions	Q9QUQ5, Q62350, Q9QUQ9, Q9QZC0	Gene names	Trpc4, Trrp4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (Receptor- activated cation channel TRP4) (Capacitative calcium entry channel Trp4).

PZRN3_HUMAN
θ value	2.36792 (rank : 418)	NC score	0.029788 (rank : 513)
Query Neighborhood Hits	471	Target Neighborhood Hits	461	Shared Neighborhood Hits	87
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

RN123_MOUSE
θ value	2.36792 (rank : 419)	NC score	0.044912 (rank : 507)
Query Neighborhood Hits	471	Target Neighborhood Hits	174	Shared Neighborhood Hits	73
SwissProt Accessions	Q5XPI3, Q6PGE0	Gene names	Rnf123, Kpc1
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase subunit KPC1 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123).

TRI18_HUMAN
θ value	2.36792 (rank : 420)	NC score	0.054819 (rank : 484)
Query Neighborhood Hits	471	Target Neighborhood Hits	307	Shared Neighborhood Hits	93
SwissProt Accessions	O15344, O75361, Q9BZX5	Gene names	MID1, FXY, RNF59, TRIM18, XPRF
Domain Architecture
Description	Midline-1 (EC 6.3.2.-) (Tripartite motif-containing protein 18) (Putative transcription factor XPRF) (Midin) (RING finger protein 59) (Midline 1 RING finger protein).

TRI18_MOUSE
θ value	2.36792 (rank : 421)	NC score	0.055810 (rank : 479)
Query Neighborhood Hits	471	Target Neighborhood Hits	292	Shared Neighborhood Hits	96
SwissProt Accessions	O70583, O35418, Q7TPT6	Gene names	Mid1, Fxy, Trim18
Domain Architecture
Description	Midline-1 (EC 6.3.2.-) (Tripartite motif-containing protein 18) (Midin).

TRIM1_HUMAN
θ value	2.36792 (rank : 422)	NC score	0.056816 (rank : 473)
Query Neighborhood Hits	471	Target Neighborhood Hits	345	Shared Neighborhood Hits	101
SwissProt Accessions	Q9UJV3, Q5JYF5, Q8WWK1, Q9UJR9	Gene names	MID2, FXY2, RNF60, TRIM1
Domain Architecture
Description	Midline-2 (Midline defect 2) (Tripartite motif-containing protein 1) (Midin-2) (RING finger protein 60).

TRIM1_MOUSE
θ value	2.36792 (rank : 423)	NC score	0.055896 (rank : 478)
Query Neighborhood Hits	471	Target Neighborhood Hits	361	Shared Neighborhood Hits	101
SwissProt Accessions	Q9QUS6	Gene names	Mid2, Fxy2, Trim1
Domain Architecture
Description	Midline-2 (Midline defect 2) (Tripartite motif-containing protein 1).

DTX3_HUMAN
θ value	3.0926 (rank : 424)	NC score	0.064700 (rank : 452)
Query Neighborhood Hits	471	Target Neighborhood Hits	198	Shared Neighborhood Hits	76
SwissProt Accessions	Q8N9I9, Q8NAU6, Q8NDS8	Gene names	DTX3
Domain Architecture
Description	Protein deltex-3 (Deltex-3) (Deltex3).

FHL1_HUMAN
θ value	3.0926 (rank : 425)	NC score	-0.001934 (rank : 525)
Query Neighborhood Hits	471	Target Neighborhood Hits	436	Shared Neighborhood Hits	5
SwissProt Accessions	Q13642, O95212, Q13230, Q13645, Q5M7Y6, Q9NZ40, Q9UKZ8, Q9Y630	Gene names	FHL1, SLIM1
Domain Architecture
Description	Four and a half LIM domains protein 1 (FHL-1) (Skeletal muscle LIM- protein 1) (SLIM 1) (SLIM).

ITB1_HUMAN
θ value	3.0926 (rank : 426)	NC score	0.021213 (rank : 516)
Query Neighborhood Hits	471	Target Neighborhood Hits	298	Shared Neighborhood Hits	15
SwissProt Accessions	P05556, P78466, P78467, Q13089, Q13090, Q13091, Q13212, Q14622, Q14647	Gene names	ITGB1, FNRB
Domain Architecture
Description	Integrin beta-1 precursor (Fibronectin receptor subunit beta) (Integrin VLA-4 subunit beta) (CD29 antigen).

PZRN3_MOUSE
θ value	3.0926 (rank : 427)	NC score	0.029290 (rank : 514)
Query Neighborhood Hits	471	Target Neighborhood Hits	447	Shared Neighborhood Hits	88
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

TRI10_MOUSE
θ value	3.0926 (rank : 428)	NC score	0.078076 (rank : 399)
Query Neighborhood Hits	471	Target Neighborhood Hits	285	Shared Neighborhood Hits	99
SwissProt Accessions	Q9WUH5, Q80WA9, Q9CY03	Gene names	Trim10, Herf1, Rnf9
Domain Architecture
Description	Tripartite motif-containing protein 10 (RING finger protein 9) (Hematopoietic RING finger 1).

TRIM2_HUMAN
θ value	3.0926 (rank : 429)	NC score	0.056521 (rank : 475)
Query Neighborhood Hits	471	Target Neighborhood Hits	330	Shared Neighborhood Hits	98
SwissProt Accessions	Q9C040, O60272, Q9BSI9, Q9UFZ1	Gene names	TRIM2, KIAA0517, RNF86
Domain Architecture
Description	Tripartite motif-containing protein 2 (RING finger protein 86).

ANKZ1_MOUSE
θ value	4.03905 (rank : 430)	NC score	0.309209 (rank : 276)
Query Neighborhood Hits	471	Target Neighborhood Hits	208	Shared Neighborhood Hits	153
SwissProt Accessions	Q80UU1, Q9CZF5	Gene names	Ankzf1, D1Ertd161e
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1.

ARX_HUMAN
θ value	4.03905 (rank : 431)	NC score	-0.008006 (rank : 532)
Query Neighborhood Hits	471	Target Neighborhood Hits	401	Shared Neighborhood Hits	4
SwissProt Accessions	Q96QS3	Gene names	ARX
Domain Architecture
Description	Homeobox protein ARX (Aristaless-related homeobox).

PAR1_HUMAN
θ value	4.03905 (rank : 432)	NC score	-0.011932 (rank : 534)
Query Neighborhood Hits	471	Target Neighborhood Hits	654	Shared Neighborhood Hits	2
SwissProt Accessions	P25116, Q96RF7, Q9BUN4	Gene names	F2R, CF2R, PAR1, TR
Domain Architecture
Description	Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) (Coagulation factor II receptor).

RNF5_HUMAN
θ value	4.03905 (rank : 433)	NC score	0.074951 (rank : 406)
Query Neighborhood Hits	471	Target Neighborhood Hits	206	Shared Neighborhood Hits	90
SwissProt Accessions	Q99942, Q9UMQ2	Gene names	RNF5, G16, NG2, RMA1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (HsRma1) (RING finger protein 5) (Protein G16).

RNF5_MOUSE
θ value	4.03905 (rank : 434)	NC score	0.074926 (rank : 407)
Query Neighborhood Hits	471	Target Neighborhood Hits	206	Shared Neighborhood Hits	89
SwissProt Accessions	O35445	Gene names	Rnf5, Ng2
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (RING finger protein 5).

TRIM2_MOUSE
θ value	4.03905 (rank : 435)	NC score	0.055682 (rank : 480)
Query Neighborhood Hits	471	Target Neighborhood Hits	331	Shared Neighborhood Hits	98
SwissProt Accessions	Q9ESN6, Q3UHP5, Q8C981	Gene names	Trim2, Narf
Domain Architecture
Description	Tripartite motif-containing protein 2 (Neural activity-related RING finger protein).

TRPC6_HUMAN
θ value	4.03905 (rank : 436)	NC score	0.104263 (rank : 344)
Query Neighborhood Hits	471	Target Neighborhood Hits	171	Shared Neighborhood Hits	108
SwissProt Accessions	Q9Y210, Q9HCW3, Q9NQA8, Q9NQA9	Gene names	TRPC6, TRP6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6).

TRPC6_MOUSE
θ value	4.03905 (rank : 437)	NC score	0.078309 (rank : 398)
Query Neighborhood Hits	471	Target Neighborhood Hits	171	Shared Neighborhood Hits	94
SwissProt Accessions	Q61143, Q9Z2J1	Gene names	Trpc6, Trp6, Trrp6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6) (Calcium entry channel).

TRPV4_HUMAN
θ value	4.03905 (rank : 438)	NC score	0.139145 (rank : 314)
Query Neighborhood Hits	471	Target Neighborhood Hits	150	Shared Neighborhood Hits	86
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

ABCAC_HUMAN
θ value	5.27518 (rank : 439)	NC score	-0.002124 (rank : 528)
Query Neighborhood Hits	471	Target Neighborhood Hits	123	Shared Neighborhood Hits	2
SwissProt Accessions	Q86UK0, Q8IZW6, Q96JT3, Q9Y4M5	Gene names	ABCA12, ABC12
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 12 (ATP-binding cassette transporter 12) (ATP-binding cassette 12).

PEX10_HUMAN
θ value	5.27518 (rank : 440)	NC score	0.092672 (rank : 367)
Query Neighborhood Hits	471	Target Neighborhood Hits	255	Shared Neighborhood Hits	105
SwissProt Accessions	O60683, Q5T095, Q9BW90	Gene names	PEX10, RNF69
Domain Architecture
Description	Peroxisome assembly protein 10 (Peroxin-10) (Peroxisome biogenesis factor 10) (RING finger protein 69).

TRI38_HUMAN
θ value	5.27518 (rank : 441)	NC score	0.075247 (rank : 405)
Query Neighborhood Hits	471	Target Neighborhood Hits	373	Shared Neighborhood Hits	89
SwissProt Accessions	O00635	Gene names	TRIM38, RNF15, RORET
Domain Architecture
Description	Tripartite motif-containing protein 38 (RING finger protein 15) (Zinc finger protein RoRet).

TRI63_HUMAN
θ value	5.27518 (rank : 442)	NC score	0.065708 (rank : 446)
Query Neighborhood Hits	471	Target Neighborhood Hits	298	Shared Neighborhood Hits	79
SwissProt Accessions	Q969Q1, Q5T2I1, Q96BD3, Q96KD9, Q9BYV4	Gene names	TRIM63, IRF, MURF1, RNF28, SMRZ
Domain Architecture
Description	Ubiquitin ligase TRIM63 (EC 6.3.2.-) (Tripartite motif-containing protein 63) (Muscle-specific RING finger protein 1) (MuRF1) (MURF-1) (RING finger protein 28) (Striated muscle RING zinc finger protein) (Iris RING finger protein).

TRI63_MOUSE
θ value	5.27518 (rank : 443)	NC score	0.063763 (rank : 459)
Query Neighborhood Hits	471	Target Neighborhood Hits	240	Shared Neighborhood Hits	75
SwissProt Accessions	Q38HM4, Q8BWC4	Gene names	Trim63, Murf1, Rf1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase TRIM63 (EC 6.3.2.-) (Tripartite motif-containing protein 63) (Muscle-specific RING finger protein 1) (MuRF1) (MURF-1) (Muscle RING finger protein 1).

ANKR9_MOUSE
θ value	6.88961 (rank : 444)	NC score	0.272710 (rank : 282)
Query Neighborhood Hits	471	Target Neighborhood Hits	120	Shared Neighborhood Hits	117
SwissProt Accessions	Q8BH83, Q3TA09, Q8BHR3	Gene names	Ankrd9
Domain Architecture
Description	Ankyrin repeat domain-containing protein 9.

CEND3_MOUSE
θ value	6.88961 (rank : 445)	NC score	0.036420 (rank : 512)
Query Neighborhood Hits	471	Target Neighborhood Hits	228	Shared Neighborhood Hits	28
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

PHF14_MOUSE
θ value	6.88961 (rank : 446)	NC score	0.000609 (rank : 523)
Query Neighborhood Hits	471	Target Neighborhood Hits	342	Shared Neighborhood Hits	13
SwissProt Accessions	Q9D4H9, Q810Z6, Q8C284, Q8CGF8, Q9D1Q8	Gene names	Phf14
Domain Architecture
Description	PHD finger protein 14.

RN123_HUMAN
θ value	6.88961 (rank : 447)	NC score	0.041733 (rank : 511)
Query Neighborhood Hits	471	Target Neighborhood Hits	175	Shared Neighborhood Hits	71
SwissProt Accessions	Q5XPI4, Q5I022, Q6PFW4, Q71RH0, Q8IW18, Q9H0M8, Q9H5L8, Q9H9T2	Gene names	RNF123, KPC1
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase subunit KPC1 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123).

TRI54_HUMAN
θ value	6.88961 (rank : 448)	NC score	0.060459 (rank : 463)
Query Neighborhood Hits	471	Target Neighborhood Hits	209	Shared Neighborhood Hits	77
SwissProt Accessions	Q9BYV2, Q53SY4, Q9BYV3	Gene names	TRIM54, MURF, MURF3, RNF30
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 54 (Muscle-specific RING finger protein 3) (MuRF3) (MURF-3) (Muscle-specific RING finger protein) (MuRF) (RING finger protein 30).

TRI54_MOUSE
θ value	6.88961 (rank : 449)	NC score	0.060340 (rank : 464)
Query Neighborhood Hits	471	Target Neighborhood Hits	197	Shared Neighborhood Hits	75
SwissProt Accessions	Q9ERP3	Gene names	Trim54, Murf, Rnf30
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 54 (Muscle-specific RING finger protein 3) (MuRF3) (MURF-3) (Muscle-specific RING finger protein) (MuRF) (RING finger protein 30).

TRPV2_MOUSE
θ value	6.88961 (rank : 450)	NC score	0.175216 (rank : 303)
Query Neighborhood Hits	471	Target Neighborhood Hits	111	Shared Neighborhood Hits	97
SwissProt Accessions	Q9WTR1, Q99K71	Gene names	Trpv2, Grc
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Growth factor-regulated calcium channel) (GRC).

ZN319_HUMAN
θ value	6.88961 (rank : 451)	NC score	-0.013745 (rank : 536)
Query Neighborhood Hits	471	Target Neighborhood Hits	772	Shared Neighborhood Hits	17
SwissProt Accessions	Q9P2F9	Gene names	ZNF319, KIAA1388
Domain Architecture	No domain graphic available
Description	Zinc finger protein 319.

ZN319_MOUSE
θ value	6.88961 (rank : 452)	NC score	-0.013856 (rank : 537)
Query Neighborhood Hits	471	Target Neighborhood Hits	762	Shared Neighborhood Hits	14
SwissProt Accessions	Q9ERR8	Gene names	Znf319, Zfp319
Domain Architecture	No domain graphic available
Description	Zinc finger protein 319.

ANKR9_HUMAN
θ value	8.99809 (rank : 453)	NC score	0.223489 (rank : 291)
Query Neighborhood Hits	471	Target Neighborhood Hits	99	Shared Neighborhood Hits	98
SwissProt Accessions	Q96BM1	Gene names	ANKRD9
Domain Architecture
Description	Ankyrin repeat domain-containing protein 9.

CCD76_HUMAN
θ value	8.99809 (rank : 454)	NC score	0.007823 (rank : 521)
Query Neighborhood Hits	471	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NUP7, Q5VVL0, Q9NW65	Gene names	CCDC76
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 76.

CENG3_HUMAN
θ value	8.99809 (rank : 455)	NC score	0.296998 (rank : 281)
Query Neighborhood Hits	471	Target Neighborhood Hits	455	Shared Neighborhood Hits	229
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_MOUSE
θ value	8.99809 (rank : 456)	NC score	0.297284 (rank : 280)
Query Neighborhood Hits	471	Target Neighborhood Hits	467	Shared Neighborhood Hits	229
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

JTB_MOUSE
θ value	8.99809 (rank : 457)	NC score	0.010259 (rank : 520)
Query Neighborhood Hits	471	Target Neighborhood Hits	4	Shared Neighborhood Hits	3
SwissProt Accessions	O88824	Gene names	Jtb
Domain Architecture
Description	Protein JTB precursor.

KRA24_HUMAN
θ value	8.99809 (rank : 458)	NC score	0.007005 (rank : 522)
Query Neighborhood Hits	471	Target Neighborhood Hits	192	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BYR9, Q495J2	Gene names	KRTAP2-4, KAP2.4, KRTAP2.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 2-4 (Keratin-associated protein 2.4) (High sulfur keratin-associated protein 2.4).

MT3_HUMAN
θ value	8.99809 (rank : 459)	NC score	0.012010 (rank : 518)
Query Neighborhood Hits	471	Target Neighborhood Hits	82	Shared Neighborhood Hits	8
SwissProt Accessions	P25713, Q2V574	Gene names	MT3
Domain Architecture	No domain graphic available
Description	Metallothionein-3 (MT-3) (Metallothionein-III) (MT-III) (Growth inhibitory factor) (GIF) (GIFB).

PACN2_HUMAN
θ value	8.99809 (rank : 460)	NC score	0.011324 (rank : 519)
Query Neighborhood Hits	471	Target Neighborhood Hits	339	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PZRN4_HUMAN
θ value	8.99809 (rank : 461)	NC score	0.026188 (rank : 515)
Query Neighborhood Hits	471	Target Neighborhood Hits	438	Shared Neighborhood Hits	83
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

THA_HUMAN
θ value	8.99809 (rank : 462)	NC score	-0.003359 (rank : 531)
Query Neighborhood Hits	471	Target Neighborhood Hits	113	Shared Neighborhood Hits	5
SwissProt Accessions	P10827, P21205, Q8N6A1, Q96H73	Gene names	THRA, ERBA1, NR1A1, THRA1
Domain Architecture
Description	Thyroid hormone receptor alpha (C-erbA-alpha) (c-erbA-1) (EAR-7) (EAR7).

THA_MOUSE
θ value	8.99809 (rank : 463)	NC score	-0.003357 (rank : 530)
Query Neighborhood Hits	471	Target Neighborhood Hits	113	Shared Neighborhood Hits	5
SwissProt Accessions	P63058, P10685, P15827, P16416, P37241, Q63107, Q63195, Q63196, Q99146	Gene names	Thra, C-erba-alpha, Nr1a1
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor alpha (C-erbA-alpha) (c-erbA-1).

TNR23_MOUSE
θ value	8.99809 (rank : 464)	NC score	-0.001328 (rank : 524)
Query Neighborhood Hits	471	Target Neighborhood Hits	114	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ER63, Q8VHC0	Gene names	Tnfrsf23, Dctrailr1, Tnfrh1, Tnfrsf1al1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 23 precursor (Tumor necrosis factor receptor p60 homolog 1) (TNF receptor family member SOB) (Decoy TRAIL receptor 1) (TNF receptor homolog 1).

TR4_HUMAN
θ value	8.99809 (rank : 465)	NC score	-0.002105 (rank : 527)
Query Neighborhood Hits	471	Target Neighborhood Hits	117	Shared Neighborhood Hits	6
SwissProt Accessions	P49116, P55092	Gene names	NR2C2, TAK1, TR4
Domain Architecture
Description	Orphan nuclear receptor TR4 (Orphan nuclear receptor TAK1).

TR4_MOUSE
θ value	8.99809 (rank : 466)	NC score	-0.002007 (rank : 526)
Query Neighborhood Hits	471	Target Neighborhood Hits	115	Shared Neighborhood Hits	7
SwissProt Accessions	P49117, P55093	Gene names	Nr2c2, Mtr2r1, Tak1, Tr4
Domain Architecture
Description	Orphan nuclear receptor TR4 (Orphan nuclear receptor TAK1).

TRI47_HUMAN
θ value	8.99809 (rank : 467)	NC score	0.065288 (rank : 450)
Query Neighborhood Hits	471	Target Neighborhood Hits	286	Shared Neighborhood Hits	90
SwissProt Accessions	Q96LD4, Q96GU5, Q9BRN7	Gene names	TRIM47, GOA, RNF100
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47 (Gene overexpressed in astrocytoma protein) (RING finger protein 100).

TRI47_MOUSE
θ value	8.99809 (rank : 468)	NC score	0.066270 (rank : 442)
Query Neighborhood Hits	471	Target Neighborhood Hits	295	Shared Neighborhood Hits	92
SwissProt Accessions	Q8C0E3, Q6P249, Q811J7, Q8BVZ8, Q8R1K0, Q8R3Y1	Gene names	Trim47
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47.

TRPC7_HUMAN
θ value	8.99809 (rank : 469)	NC score	0.070981 (rank : 416)
Query Neighborhood Hits	471	Target Neighborhood Hits	123	Shared Neighborhood Hits	77
SwissProt Accessions	Q9HCX4	Gene names	TRPC7, TRP7
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (TRP7 protein).

TRPC7_MOUSE
θ value	8.99809 (rank : 470)	NC score	0.071158 (rank : 415)
Query Neighborhood Hits	471	Target Neighborhood Hits	114	Shared Neighborhood Hits	77
SwissProt Accessions	Q9WVC5	Gene names	Trpc7, Trp7, Trrp8
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (mTRP7).

TRPV4_MOUSE
θ value	8.99809 (rank : 471)	NC score	0.127214 (rank : 319)
Query Neighborhood Hits	471	Target Neighborhood Hits	117	Shared Neighborhood Hits	83
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

ANKF1_HUMAN
θ value	θ > 10 (rank : 472)	NC score	0.136579 (rank : 317)
Query Neighborhood Hits	471	Target Neighborhood Hits	126	Shared Neighborhood Hits	68
SwissProt Accessions	Q8N957	Gene names	ANKFN1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and fibronectin type-III domain-containing protein 1.

BAT4_HUMAN
θ value	θ > 10 (rank : 473)	NC score	0.219581 (rank : 293)
Query Neighborhood Hits	471	Target Neighborhood Hits	157	Shared Neighborhood Hits	108
SwissProt Accessions	O95872	Gene names	BAT4, G5
Domain Architecture
Description	Protein BAT4 (HLA-B-associated transcript 4) (G5 protein).

BAT4_MOUSE
θ value	θ > 10 (rank : 474)	NC score	0.244496 (rank : 288)
Query Neighborhood Hits	471	Target Neighborhood Hits	171	Shared Neighborhood Hits	118
SwissProt Accessions	Q61858, Q9R065	Gene names	Bat4, Bat-4, G5
Domain Architecture
Description	Protein BAT4 (HLA-B-associated transcript 4) (G5 protein).

BFAR_HUMAN
θ value	θ > 10 (rank : 475)	NC score	0.057305 (rank : 468)
Query Neighborhood Hits	471	Target Neighborhood Hits	222	Shared Neighborhood Hits	82
SwissProt Accessions	Q9NZS9	Gene names	BFAR, BAR, RNF47
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator (RING finger protein 47).

BFAR_MOUSE
θ value	θ > 10 (rank : 476)	NC score	0.056339 (rank : 476)
Query Neighborhood Hits	471	Target Neighborhood Hits	232	Shared Neighborhood Hits	85
SwissProt Accessions	Q8R079, Q8C1A7, Q9CXY3	Gene names	Bfar
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator.

BRE1A_HUMAN
θ value	θ > 10 (rank : 477)	NC score	0.052102 (rank : 492)
Query Neighborhood Hits	471	Target Neighborhood Hits	1071	Shared Neighborhood Hits	96
SwissProt Accessions	Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83	Gene names	RNF20, BRE1A
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (hBRE1) (RING finger protein 20).

CMTA1_HUMAN
θ value	θ > 10 (rank : 478)	NC score	0.174279 (rank : 304)
Query Neighborhood Hits	471	Target Neighborhood Hits	217	Shared Neighborhood Hits	100
SwissProt Accessions	Q9Y6Y1, Q5VUE1	Gene names	CAMTA1, KIAA0833
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 1.

CMTA2_HUMAN
θ value	θ > 10 (rank : 479)	NC score	0.134539 (rank : 318)
Query Neighborhood Hits	471	Target Neighborhood Hits	199	Shared Neighborhood Hits	87
SwissProt Accessions	O94983, Q7Z6M8, Q8N3V0, Q8NDG4, Q96G17	Gene names	CAMTA2, KIAA0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

CMTA2_MOUSE
θ value	θ > 10 (rank : 480)	NC score	0.122760 (rank : 323)
Query Neighborhood Hits	471	Target Neighborhood Hits	216	Shared Neighborhood Hits	77
SwissProt Accessions	Q80Y50, Q3TFK0, Q5SX68, Q80TP1, Q8R0D9, Q8R2N5	Gene names	Camta2, Kiaa0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

CU081_HUMAN
θ value	θ > 10 (rank : 481)	NC score	0.138455 (rank : 315)
Query Neighborhood Hits	471	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NFU9	Gene names	C21orf81
Domain Architecture	No domain graphic available
Description	Protein C21orf81.

MEFV_HUMAN
θ value	θ > 10 (rank : 482)	NC score	0.056955 (rank : 470)
Query Neighborhood Hits	471	Target Neighborhood Hits	431	Shared Neighborhood Hits	57
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

MEFV_MOUSE
θ value	θ > 10 (rank : 483)	NC score	0.055922 (rank : 477)
Query Neighborhood Hits	471	Target Neighborhood Hits	236	Shared Neighborhood Hits	54
SwissProt Accessions	Q9JJ26	Gene names	Mefv
Domain Architecture
Description	Pyrin (Marenostrin).

RAD18_MOUSE
θ value	θ > 10 (rank : 484)	NC score	0.050381 (rank : 501)
Query Neighborhood Hits	471	Target Neighborhood Hits	230	Shared Neighborhood Hits	79
SwissProt Accessions	Q9QXK2, Q9CZB8	Gene names	Rad18, Rad18sc
Domain Architecture
Description	Postreplication repair protein RAD18 (mRAD18Sc).

RELB_HUMAN
θ value	θ > 10 (rank : 485)	NC score	0.066757 (rank : 439)
Query Neighborhood Hits	471	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	Q01201, Q6GTX7, Q9UEI7	Gene names	RELB
Domain Architecture
Description	Transcription factor RelB (I-Rel).

RELB_MOUSE
θ value	θ > 10 (rank : 486)	NC score	0.066792 (rank : 437)
Query Neighborhood Hits	471	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q04863	Gene names	Relb
Domain Architecture
Description	Transcription factor RelB.

REL_HUMAN
θ value	θ > 10 (rank : 487)	NC score	0.068118 (rank : 430)
Query Neighborhood Hits	471	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q04864, Q2PNZ7, Q6LDY0	Gene names	REL
Domain Architecture
Description	C-Rel proto-oncogene protein (C-Rel protein).

REL_MOUSE
θ value	θ > 10 (rank : 488)	NC score	0.068644 (rank : 428)
Query Neighborhood Hits	471	Target Neighborhood Hits	77	Shared Neighborhood Hits	5
SwissProt Accessions	P15307	Gene names	Rel
Domain Architecture
Description	C-Rel proto-oncogene protein (C-Rel protein).

RN125_HUMAN
θ value	θ > 10 (rank : 489)	NC score	0.052727 (rank : 487)
Query Neighborhood Hits	471	Target Neighborhood Hits	230	Shared Neighborhood Hits	87
SwissProt Accessions	Q96EQ8, Q9NX39	Gene names	RNF125
Domain Architecture	No domain graphic available
Description	RING finger protein 125 (EC 6.3.2.-) (T-cell RING activation protein 1) (TRAC-1).

RN125_MOUSE
θ value	θ > 10 (rank : 490)	NC score	0.054444 (rank : 485)
Query Neighborhood Hits	471	Target Neighborhood Hits	220	Shared Neighborhood Hits	88
SwissProt Accessions	Q9D9R0, Q52KL4, Q8C7F2	Gene names	Rnf125
Domain Architecture	No domain graphic available
Description	RING finger protein 125 (EC 6.3.2.-).

RN166_HUMAN
θ value	θ > 10 (rank : 491)	NC score	0.071598 (rank : 413)
Query Neighborhood Hits	471	Target Neighborhood Hits	240	Shared Neighborhood Hits	98
SwissProt Accessions	Q96A37, Q96DM0	Gene names	RNF166
Domain Architecture	No domain graphic available
Description	RING finger protein 166.

RN166_MOUSE
θ value	θ > 10 (rank : 492)	NC score	0.070026 (rank : 421)
Query Neighborhood Hits	471	Target Neighborhood Hits	248	Shared Neighborhood Hits	98
SwissProt Accessions	Q3U9F6	Gene names	Rnf166
Domain Architecture	No domain graphic available
Description	RING finger protein 166.

RN168_HUMAN
θ value	θ > 10 (rank : 493)	NC score	0.068946 (rank : 424)
Query Neighborhood Hits	471	Target Neighborhood Hits	370	Shared Neighborhood Hits	108
SwissProt Accessions	Q8IYW5, Q8NA67, Q96NS4	Gene names	RNF168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

RN168_MOUSE
θ value	θ > 10 (rank : 494)	NC score	0.064078 (rank : 458)
Query Neighborhood Hits	471	Target Neighborhood Hits	440	Shared Neighborhood Hits	104
SwissProt Accessions	Q80XJ2	Gene names	Rnf168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

RNF39_HUMAN
θ value	θ > 10 (rank : 495)	NC score	0.055090 (rank : 483)
Query Neighborhood Hits	471	Target Neighborhood Hits	200	Shared Neighborhood Hits	71
SwissProt Accessions	Q9H2S5, Q5SPM8, Q5SPM9, Q5SPN0, Q5SRJ9, Q5SRK1, Q5SS29, Q9H2S3, Q9H2S4	Gene names	RNF39, HZFW
Domain Architecture	No domain graphic available
Description	RING finger protein 39 (Protein HZFw).

RNF41_HUMAN
θ value	θ > 10 (rank : 496)	NC score	0.050218 (rank : 502)
Query Neighborhood Hits	471	Target Neighborhood Hits	226	Shared Neighborhood Hits	82
SwissProt Accessions	Q9H4P4, O75598	Gene names	RNF41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

RNF41_MOUSE
θ value	θ > 10 (rank : 497)	NC score	0.050385 (rank : 500)
Query Neighborhood Hits	471	Target Neighborhood Hits	224	Shared Neighborhood Hits	82
SwissProt Accessions	Q8BH75, Q8BGJ2, Q8BMC9, Q8VEA2, Q9CRK6, Q9D568	Gene names	Rnf41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

RNF4_HUMAN
θ value	θ > 10 (rank : 498)	NC score	0.066955 (rank : 436)
Query Neighborhood Hits	471	Target Neighborhood Hits	212	Shared Neighborhood Hits	80
SwissProt Accessions	P78317	Gene names	RNF4
Domain Architecture
Description	RING finger protein 4.

RNF4_MOUSE
θ value	θ > 10 (rank : 499)	NC score	0.066668 (rank : 440)
Query Neighborhood Hits	471	Target Neighborhood Hits	212	Shared Neighborhood Hits	80
SwissProt Accessions	Q9QZS2, O35941, Q541Z6	Gene names	Rnf4
Domain Architecture
Description	RING finger protein 4.

RO52_MOUSE
θ value	θ > 10 (rank : 500)	NC score	0.091407 (rank : 373)
Query Neighborhood Hits	471	Target Neighborhood Hits	360	Shared Neighborhood Hits	116
SwissProt Accessions	Q62191	Gene names	Trim21, Ro52, Ssa1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21).

SSB4_HUMAN
θ value	θ > 10 (rank : 501)	NC score	0.051117 (rank : 496)
Query Neighborhood Hits	471	Target Neighborhood Hits	47	Shared Neighborhood Hits	28
SwissProt Accessions	Q96A44	Gene names	SPSB4, SSB4
Domain Architecture	No domain graphic available
Description	SPRY domain-containing SOCS box protein 4 (SSB-4).

TF65_HUMAN
θ value	θ > 10 (rank : 502)	NC score	0.065494 (rank : 447)
Query Neighborhood Hits	471	Target Neighborhood Hits	115	Shared Neighborhood Hits	7
SwissProt Accessions	Q04206, Q6SLK1	Gene names	RELA, NFKB3
Domain Architecture
Description	Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit).

TF65_MOUSE
θ value	θ > 10 (rank : 503)	NC score	0.066268 (rank : 443)
Query Neighborhood Hits	471	Target Neighborhood Hits	66	Shared Neighborhood Hits	6
SwissProt Accessions	Q04207, Q62025	Gene names	Rela, Nfkb3
Domain Architecture
Description	Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit).

TRI11_HUMAN
θ value	θ > 10 (rank : 504)	NC score	0.079024 (rank : 396)
Query Neighborhood Hits	471	Target Neighborhood Hits	316	Shared Neighborhood Hits	108
SwissProt Accessions	Q96F44, Q8NCA6, Q9C022	Gene names	TRIM11, RNF92
Domain Architecture
Description	Tripartite motif-containing protein 11 (EC 6.3.2.-) (RING finger protein 92) (Protein BIA1).

TRI11_MOUSE
θ value	θ > 10 (rank : 505)	NC score	0.079036 (rank : 395)
Query Neighborhood Hits	471	Target Neighborhood Hits	329	Shared Neighborhood Hits	108
SwissProt Accessions	Q99PQ2, Q8VDX5	Gene names	Trim11
Domain Architecture
Description	Tripartite motif-containing protein 11 (EC 6.3.2.-).

TRI13_HUMAN
θ value	θ > 10 (rank : 506)	NC score	0.066782 (rank : 438)
Query Neighborhood Hits	471	Target Neighborhood Hits	274	Shared Neighborhood Hits	89
SwissProt Accessions	O60858, Q9BQ47, Q9C021	Gene names	TRIM13, LEU5, RFP2, RNF77
Domain Architecture
Description	Tripartite motif-containing protein 13 (Ret finger protein 2) (Putative tumor suppressor RFP2) (Leukemia-associated protein 5) (B- cell chronic lymphocytic leukemia tumor suppressor Leu5) (RING finger protein 77).

TRI13_MOUSE
θ value	θ > 10 (rank : 507)	NC score	0.067427 (rank : 432)
Query Neighborhood Hits	471	Target Neighborhood Hits	282	Shared Neighborhood Hits	91
SwissProt Accessions	Q9CYB0, Q8CEV0, Q923J0, Q925P1, Q99PQ0	Gene names	Trim13, Rfp2
Domain Architecture
Description	Tripartite motif-containing protein 13 (Ret finger protein 2) (Putative tumor suppressor RFP2).

TRI17_HUMAN
θ value	θ > 10 (rank : 508)	NC score	0.075695 (rank : 403)
Query Neighborhood Hits	471	Target Neighborhood Hits	318	Shared Neighborhood Hits	105
SwissProt Accessions	Q9Y577	Gene names	TRIM17, RBCC, RNF16, TERF
Domain Architecture
Description	Tripartite motif-containing protein 17 (Testis RING finger protein) (RING finger protein 16).

TRI17_MOUSE
θ value	θ > 10 (rank : 509)	NC score	0.078417 (rank : 397)
Query Neighborhood Hits	471	Target Neighborhood Hits	620	Shared Neighborhood Hits	108
SwissProt Accessions	Q7TPM3, Q99PP8	Gene names	Trim17
Domain Architecture
Description	Tripartite motif-containing protein 17.

TRI25_HUMAN
θ value	θ > 10 (rank : 510)	NC score	0.063640 (rank : 460)
Query Neighborhood Hits	471	Target Neighborhood Hits	472	Shared Neighborhood Hits	105
SwissProt Accessions	Q14258	Gene names	TRIM25, EFP, RNF147, ZNF147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp) (RING finger protein 147).

TRI32_HUMAN
θ value	θ > 10 (rank : 511)	NC score	0.056938 (rank : 471)
Query Neighborhood Hits	471	Target Neighborhood Hits	264	Shared Neighborhood Hits	84
SwissProt Accessions	Q13049, Q9NQP8	Gene names	TRIM32, HT2A
Domain Architecture
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-) (Zinc finger protein HT2A) (72 kDa Tat-interacting protein).

TRI32_MOUSE
θ value	θ > 10 (rank : 512)	NC score	0.056696 (rank : 474)
Query Neighborhood Hits	471	Target Neighborhood Hits	271	Shared Neighborhood Hits	86
SwissProt Accessions	Q8CH72, Q8K055	Gene names	Trim32
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-).

TRI37_HUMAN
θ value	θ > 10 (rank : 513)	NC score	0.055610 (rank : 481)
Query Neighborhood Hits	471	Target Neighborhood Hits	307	Shared Neighborhood Hits	88
SwissProt Accessions	O94972, Q7Z3E6, Q8IYF7, Q8WYF7	Gene names	TRIM37, KIAA0898, MUL, POB1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37 (Mulibrey nanism protein).

TRI37_MOUSE
θ value	θ > 10 (rank : 514)	NC score	0.055305 (rank : 482)
Query Neighborhood Hits	471	Target Neighborhood Hits	316	Shared Neighborhood Hits	87
SwissProt Accessions	Q6PCX9, Q8CHC5	Gene names	Trim37, Kiaa0898
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37.

TRI40_HUMAN
θ value	θ > 10 (rank : 515)	NC score	0.086269 (rank : 382)
Query Neighborhood Hits	471	Target Neighborhood Hits	279	Shared Neighborhood Hits	96
SwissProt Accessions	Q6P9F5, Q8TD96	Gene names	TRIM40, RNF35
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 40 (RING finger protein 35).

TRI43_HUMAN
θ value	θ > 10 (rank : 516)	NC score	0.080867 (rank : 391)
Query Neighborhood Hits	471	Target Neighborhood Hits	341	Shared Neighborhood Hits	107
SwissProt Accessions	Q96BQ3	Gene names	TRIM43
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 43.

TRI48_HUMAN
θ value	θ > 10 (rank : 517)	NC score	0.068910 (rank : 425)
Query Neighborhood Hits	471	Target Neighborhood Hits	192	Shared Neighborhood Hits	80
SwissProt Accessions	Q8IWZ4, Q9BUW4	Gene names	TRIM48, RNF101
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 48 (RING finger protein 101).

TRI49_HUMAN
θ value	θ > 10 (rank : 518)	NC score	0.064475 (rank : 454)
Query Neighborhood Hits	471	Target Neighborhood Hits	199	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NS80, Q6DJV1	Gene names	TRIM49, RNF18
Domain Architecture
Description	Tripartite motif-containing protein 49 (RING finger protein 18) (Testis-specific ring-finger protein).

TRI59_HUMAN
θ value	θ > 10 (rank : 519)	NC score	0.061530 (rank : 462)
Query Neighborhood Hits	471	Target Neighborhood Hits	307	Shared Neighborhood Hits	85
SwissProt Accessions	Q8IWR1	Gene names	TRIM59, RNF104, TRIM57, TSBF1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 59 (Tumor suppressor TSBF-1) (RING finger protein 104).

TRI59_MOUSE
θ value	θ > 10 (rank : 520)	NC score	0.061722 (rank : 461)
Query Neighborhood Hits	471	Target Neighborhood Hits	292	Shared Neighborhood Hits	86
SwissProt Accessions	Q922Y2, Q9CSP2, Q9CUD5, Q9D740	Gene names	Trim59, Mrf1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 59 (RING finger protein 1).

TRI60_MOUSE
θ value	θ > 10 (rank : 521)	NC score	0.068903 (rank : 426)
Query Neighborhood Hits	471	Target Neighborhood Hits	240	Shared Neighborhood Hits	78
SwissProt Accessions	Q8VI40, Q3UX74	Gene names	Trim60, 2czf45, Rnf33
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 60 (Ring finger protein 33).

TRI62_HUMAN
θ value	θ > 10 (rank : 522)	NC score	0.071321 (rank : 414)
Query Neighborhood Hits	471	Target Neighborhood Hits	584	Shared Neighborhood Hits	100
SwissProt Accessions	Q9BVG3, Q9NVG0	Gene names	TRIM62
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 62.

TRI62_MOUSE
θ value	θ > 10 (rank : 523)	NC score	0.070095 (rank : 420)
Query Neighborhood Hits	471	Target Neighborhood Hits	478	Shared Neighborhood Hits	95
SwissProt Accessions	Q80V85	Gene names	Trim62
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 62.

TRI65_HUMAN
θ value	θ > 10 (rank : 524)	NC score	0.083989 (rank : 388)
Query Neighborhood Hits	471	Target Neighborhood Hits	330	Shared Neighborhood Hits	103
SwissProt Accessions	Q6PJ69, Q4G0F0, Q6DKJ6, Q9BRP6	Gene names	TRIM65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

TRI65_MOUSE
θ value	θ > 10 (rank : 525)	NC score	0.076518 (rank : 401)
Query Neighborhood Hits	471	Target Neighborhood Hits	340	Shared Neighborhood Hits	106
SwissProt Accessions	Q8BFW4, Q6PGD3	Gene names	Trim65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

TRIM3_HUMAN
θ value	θ > 10 (rank : 526)	NC score	0.051859 (rank : 493)
Query Neighborhood Hits	471	Target Neighborhood Hits	357	Shared Neighborhood Hits	95
SwissProt Accessions	O75382, Q9C038, Q9C039	Gene names	TRIM3, BERP, RNF22, RNF97
Domain Architecture
Description	Tripartite motif-containing protein 3 (RING finger protein 22) (Brain- expressed RING finger protein) (RING finger protein 97).

TRIM3_MOUSE
θ value	θ > 10 (rank : 527)	NC score	0.050894 (rank : 498)
Query Neighborhood Hits	471	Target Neighborhood Hits	351	Shared Neighborhood Hits	90
SwissProt Accessions	Q9R1R2, Q3UMU5	Gene names	Trim3, Hac1, Rnf22
Domain Architecture
Description	Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1).

TRIM7_HUMAN
θ value	θ > 10 (rank : 528)	NC score	0.070236 (rank : 419)
Query Neighborhood Hits	471	Target Neighborhood Hits	336	Shared Neighborhood Hits	85
SwissProt Accessions	Q9C029, Q969F5, Q96F67, Q96J89, Q96J90	Gene names	TRIM7, GNIP, RNF90
Domain Architecture
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein) (RING finger protein 90).

TRIM7_MOUSE
θ value	θ > 10 (rank : 529)	NC score	0.070933 (rank : 417)
Query Neighborhood Hits	471	Target Neighborhood Hits	358	Shared Neighborhood Hits	85
SwissProt Accessions	Q923T7, Q5NCB6, Q99PQ5	Gene names	Trim7, Gnip
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein).

TRIM8_HUMAN
θ value	θ > 10 (rank : 530)	NC score	0.065297 (rank : 449)
Query Neighborhood Hits	471	Target Neighborhood Hits	650	Shared Neighborhood Hits	93
SwissProt Accessions	Q9BZR9, Q9C028	Gene names	TRIM8, GERP, RNF27
Domain Architecture
Description	Tripartite motif-containing protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein).

TRIM8_MOUSE
θ value	θ > 10 (rank : 531)	NC score	0.064084 (rank : 457)
Query Neighborhood Hits	471	Target Neighborhood Hits	674	Shared Neighborhood Hits	94
SwissProt Accessions	Q99PJ2, Q8C508, Q8C700, Q8CGI2, Q99PQ4	Gene names	Trim8, Gerp, Rnf27
Domain Architecture
Description	Tripartite motif-containing protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein).

TRPC3_HUMAN
θ value	θ > 10 (rank : 532)	NC score	0.081705 (rank : 390)
Query Neighborhood Hits	471	Target Neighborhood Hits	137	Shared Neighborhood Hits	86
SwissProt Accessions	Q13507, O00593, Q15660	Gene names	TRPC3, TRP3
Domain Architecture
Description	Short transient receptor potential channel 3 (TrpC3) (Htrp-3) (Htrp3).

TRPC3_MOUSE
θ value	θ > 10 (rank : 533)	NC score	0.075406 (rank : 404)
Query Neighborhood Hits	471	Target Neighborhood Hits	131	Shared Neighborhood Hits	82
SwissProt Accessions	Q9QZC1, Q61058	Gene names	Trpc3, Trp3, Trrp3
Domain Architecture
Description	Short transient receptor potential channel 3 (TrpC3) (Transient receptor protein 3) (Mtrp3) (Receptor-activated cation channel TRP3) (trp-related protein 3).

TRPC5_HUMAN
θ value	θ > 10 (rank : 534)	NC score	0.064472 (rank : 455)
Query Neighborhood Hits	471	Target Neighborhood Hits	122	Shared Neighborhood Hits	76
SwissProt Accessions	Q9UL62, O75233, Q5JXY8, Q9Y514	Gene names	TRPC5, TRP5
Domain Architecture
Description	Short transient receptor potential channel 5 (TrpC5) (Htrp-5) (Htrp5).

TRPC5_MOUSE
θ value	θ > 10 (rank : 535)	NC score	0.065854 (rank : 445)
Query Neighborhood Hits	471	Target Neighborhood Hits	124	Shared Neighborhood Hits	78
SwissProt Accessions	Q9QX29, Q61059, Q9QWT1, Q9R0D4	Gene names	Trpc5, Trp5, Trrp5
Domain Architecture
Description	Short transient receptor potential channel 5 (TrpC5) (Transient receptor protein 5) (Mtrp5) (trp-related protein 5) (Capacitative calcium entry channel 2) (CCE2).

ZN313_HUMAN
θ value	θ > 10 (rank : 536)	NC score	0.065467 (rank : 448)
Query Neighborhood Hits	471	Target Neighborhood Hits	264	Shared Neighborhood Hits	103
SwissProt Accessions	Q9Y508, Q6N0B0	Gene names	ZNF313, RNF114, ZNF228
Domain Architecture
Description	Zinc finger protein 313 (RING finger protein 114).

ZN313_MOUSE
θ value	θ > 10 (rank : 537)	NC score	0.069778 (rank : 422)
Query Neighborhood Hits	471	Target Neighborhood Hits	273	Shared Neighborhood Hits	105
SwissProt Accessions	Q9ET26, Q3UFU8, Q8K5A2	Gene names	Znf313, Zfp228, Zfp313, Znf228
Domain Architecture
Description	Zinc finger protein 313.

Hits sorted by NC score

MIB1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	471	Target Neighborhood Hits	471	Shared Neighborhood Hits	471
SwissProt Accessions	Q80SY4, Q5XK51, Q6IS57, Q6YI52, Q6ZPT8, Q8BNR1, Q8C6W2, Q921Q1	Gene names	Mib1, Dip1, Kiaa1323, Mib
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1).

MIB1_HUMAN
NC score	0.999540 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	471	Target Neighborhood Hits	470	Shared Neighborhood Hits	460
SwissProt Accessions	Q86YT6, Q68D01, Q6YI51, Q8NBY0, Q8TCB5, Q8TCL7, Q9P2M3	Gene names	MIB1, DIP1, KIAA1323, ZZANK2
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB1 (EC 6.3.2.-) (Mind bomb homolog 1) (DAPK-interacting protein 1) (DIP-1) (Zinc finger ZZ type with ankyrin repeat domain protein 2).

MIB2_HUMAN
NC score	0.972018 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	471	Target Neighborhood Hits	438	Shared Neighborhood Hits	385
SwissProt Accessions	Q96AX9, Q7Z437, Q8IY62, Q8N897, Q8N8R2, Q8N911, Q8NB36, Q8NCY1, Q8NG59, Q8NG60, Q8NG61, Q8NI59, Q8WYN1	Gene names	MIB2, SKD, ZZANK1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Zinc finger ZZ type with ankyrin repeat domain protein 1) (Skeletrophin) (Novelzin) (Novel zinc finger protein) (Putative NF-kappa-B-activating protein 002N).

MIB2_MOUSE
NC score	0.970539 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	471	Target Neighborhood Hits	409	Shared Neighborhood Hits	375
SwissProt Accessions	Q8R516, Q52QU8, Q6PEF6, Q8C1N7, Q8VIB4	Gene names	Mib2, Skd
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein MIB2 (EC 6.3.2.-) (Mind bomb homolog 2) (Mind bomb-2) (Skeletrophin) (Dystrophin-like protein) (Dyslike).

ANKR6_HUMAN
NC score	0.901904 (rank : 5)	θ value	1.24688e-25 (rank : 21)
Query Neighborhood Hits	471	Target Neighborhood Hits	439	Shared Neighborhood Hits	296
SwissProt Accessions	Q9Y2G4, Q9NU24, Q9UFQ9	Gene names	ANKRD6, KIAA0957
Domain Architecture
Description	Ankyrin repeat domain-containing protein 6.

PSD10_HUMAN
NC score	0.899893 (rank : 6)	θ value	9.24701e-21 (rank : 36)
Query Neighborhood Hits	471	Target Neighborhood Hits	301	Shared Neighborhood Hits	293
SwissProt Accessions	O75832	Gene names	PSMD10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

PSD10_MOUSE
NC score	0.899186 (rank : 7)	θ value	7.0802e-21 (rank : 34)
Query Neighborhood Hits	471	Target Neighborhood Hits	293	Shared Neighborhood Hits	288
SwissProt Accessions	Q9Z2X2, Q9D7N8	Gene names	Psmd10
Domain Architecture
Description	26S proteasome non-ATPase regulatory subunit 10 (26S proteasome regulatory subunit p28) (Gankyrin).

ANR16_HUMAN
NC score	0.897114 (rank : 8)	θ value	1.33526e-19 (rank : 44)
Query Neighborhood Hits	471	Target Neighborhood Hits	286	Shared Neighborhood Hits	280
SwissProt Accessions	Q6P6B7, Q9NT01	Gene names	ANKRD16
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 16.

ANR29_HUMAN
NC score	0.895757 (rank : 9)	θ value	1.02238e-19 (rank : 43)
Query Neighborhood Hits	471	Target Neighborhood Hits	294	Shared Neighborhood Hits	290
SwissProt Accessions	Q8N6D5, Q6ZWE8, Q96LU9	Gene names	ANKRD29
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 29.

ANR50_HUMAN
NC score	0.893787 (rank : 10)	θ value	2.77775e-25 (rank : 22)
Query Neighborhood Hits	471	Target Neighborhood Hits	361	Shared Neighborhood Hits	300
SwissProt Accessions	Q9ULJ7, Q6N064, Q6ZSE6	Gene names	ANKRD50, KIAA1223
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 50.

ANR28_MOUSE
NC score	0.890178 (rank : 11)	θ value	7.29293e-34 (rank : 7)
Query Neighborhood Hits	471	Target Neighborhood Hits	314	Shared Neighborhood Hits	300
SwissProt Accessions	Q505D1	Gene names	Ankrd28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ANR28_HUMAN
NC score	0.889320 (rank : 12)	θ value	2.77131e-33 (rank : 8)
Query Neighborhood Hits	471	Target Neighborhood Hits	314	Shared Neighborhood Hits	299
SwissProt Accessions	O15084, Q6ULS0, Q6ZT57	Gene names	ANKRD28, KIAA0379
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 28.

ANR44_HUMAN
NC score	0.889196 (rank : 13)	θ value	1.85889e-29 (rank : 14)
Query Neighborhood Hits	471	Target Neighborhood Hits	318	Shared Neighborhood Hits	303
SwissProt Accessions	Q8N8A2, Q6P480, Q86VL5, Q8IZ72, Q9UFA4	Gene names	ANKRD44
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 44.

ASB3_HUMAN
NC score	0.880063 (rank : 14)	θ value	3.39556e-23 (rank : 24)
Query Neighborhood Hits	471	Target Neighborhood Hits	316	Shared Neighborhood Hits	297
SwissProt Accessions	Q9Y575, Q9NVZ2	Gene names	ASB3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

ANR52_MOUSE
NC score	0.879227 (rank : 15)	θ value	5.97985e-28 (rank : 16)
Query Neighborhood Hits	471	Target Neighborhood Hits	318	Shared Neighborhood Hits	300
SwissProt Accessions	Q8BTI7	Gene names	Ankrd52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

ASB3_MOUSE
NC score	0.878324 (rank : 16)	θ value	3.62785e-25 (rank : 23)
Query Neighborhood Hits	471	Target Neighborhood Hits	316	Shared Neighborhood Hits	292
SwissProt Accessions	Q9WV72	Gene names	Asb3
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 3 (ASB-3).

ANKR2_MOUSE
NC score	0.878287 (rank : 17)	θ value	1.2077e-20 (rank : 37)
Query Neighborhood Hits	471	Target Neighborhood Hits	312	Shared Neighborhood Hits	289
SwissProt Accessions	Q9WV06	Gene names	Ankrd2, Arpp
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (mArpp).

TNKS1_HUMAN
NC score	0.878239 (rank : 18)	θ value	2.68423e-28 (rank : 15)
Query Neighborhood Hits	471	Target Neighborhood Hits	477	Shared Neighborhood Hits	305
SwissProt Accessions	O95271, O95272	Gene names	TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1
Domain Architecture
Description	Tankyrase-1 (EC 2.4.2.30) (TANK1) (Tankyrase I) (TNKS-1) (TRF1- interacting ankyrin-related ADP-ribose polymerase).

ANR52_HUMAN
NC score	0.878082 (rank : 19)	θ value	8.63488e-27 (rank : 19)
Query Neighborhood Hits	471	Target Neighborhood Hits	322	Shared Neighborhood Hits	300
SwissProt Accessions	Q8NB46	Gene names	ANKRD52
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 52.

TNKS2_HUMAN
NC score	0.877932 (rank : 20)	θ value	1.33217e-27 (rank : 17)
Query Neighborhood Hits	471	Target Neighborhood Hits	361	Shared Neighborhood Hits	305
SwissProt Accessions	Q9H2K2, Q9H8F2, Q9HAS4	Gene names	TNKS2, PARP5B, TANK2, TNKL
Domain Architecture
Description	Tankyrase-2 (EC 2.4.2.30) (TANK2) (Tankyrase II) (TNKS-2) (TRF1- interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase-like protein) (Tankyrase-related protein).

BCL3_HUMAN
NC score	0.877414 (rank : 21)	θ value	8.65492e-19 (rank : 51)
Query Neighborhood Hits	471	Target Neighborhood Hits	324	Shared Neighborhood Hits	288
SwissProt Accessions	P20749	Gene names	BCL3
Domain Architecture
Description	B-cell lymphoma 3-encoded protein (Protein Bcl-3).

FANK1_HUMAN
NC score	0.877365 (rank : 22)	θ value	1.09485e-13 (rank : 104)
Query Neighborhood Hits	471	Target Neighborhood Hits	326	Shared Neighborhood Hits	286
SwissProt Accessions	Q8TC84, Q6UXY9, Q6X7T6	Gene names	FANK1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains protein 1.

ANKR2_HUMAN
NC score	0.877313 (rank : 23)	θ value	3.51386e-20 (rank : 39)
Query Neighborhood Hits	471	Target Neighborhood Hits	321	Shared Neighborhood Hits	289
SwissProt Accessions	Q9GZV1, Q5T456, Q8WUD7	Gene names	ANKRD2, ARPP
Domain Architecture
Description	Ankyrin repeat domain-containing protein 2 (Skeletal muscle ankyrin repeat protein) (hArpp).

ANK1_HUMAN
NC score	0.876961 (rank : 24)	θ value	4.00176e-32 (rank : 10)
Query Neighborhood Hits	471	Target Neighborhood Hits	416	Shared Neighborhood Hits	304
SwissProt Accessions	P16157, O43400, Q13768, Q59FP2, Q8N604, Q99407	Gene names	ANK1, ANK
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin) (Ankyrin-R).

INVS_HUMAN
NC score	0.876722 (rank : 25)	θ value	1.09232e-21 (rank : 31)
Query Neighborhood Hits	471	Target Neighborhood Hits	455	Shared Neighborhood Hits	291
SwissProt Accessions	Q9Y283, Q5W0T6, Q8IVX8, Q9BRB9, Q9Y488, Q9Y498	Gene names	INVS, INV, NPHP2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning homolog) (Nephrocystin-2).

ANK1_MOUSE
NC score	0.876444 (rank : 26)	θ value	1.0531e-32 (rank : 9)
Query Neighborhood Hits	471	Target Neighborhood Hits	430	Shared Neighborhood Hits	306
SwissProt Accessions	Q02357, P70440, P97446, P97941, Q3TZ35, Q3UH42, Q3UHP2, Q3UYY7, Q61302, Q61303, Q78E45	Gene names	Ank1, Ank-1
Domain Architecture
Description	Ankyrin-1 (Erythrocyte ankyrin).

ASB7_MOUSE
NC score	0.876277 (rank : 27)	θ value	6.20254e-17 (rank : 72)
Query Neighborhood Hits	471	Target Neighborhood Hits	296	Shared Neighborhood Hits	283
SwissProt Accessions	Q91ZU0	Gene names	Asb7
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 7 (ASB-7).

ASB7_HUMAN
NC score	0.876111 (rank : 28)	θ value	6.20254e-17 (rank : 71)
Query Neighborhood Hits	471	Target Neighborhood Hits	296	Shared Neighborhood Hits	283
SwissProt Accessions	Q9H672, Q7Z4S3	Gene names	ASB7
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 7 (ASB-7).

FANK1_MOUSE
NC score	0.874599 (rank : 29)	θ value	4.16044e-13 (rank : 113)
Query Neighborhood Hits	471	Target Neighborhood Hits	325	Shared Neighborhood Hits	282
SwissProt Accessions	Q9DAM9, Q9CUA7	Gene names	Fank1
Domain Architecture	No domain graphic available
Description	Fibronectin type 3 and ankyrin repeat domains 1 protein (Germ cell- specific gene 1 protein) (GSG1).

BCL3_MOUSE
NC score	0.873985 (rank : 30)	θ value	1.33526e-19 (rank : 45)
Query Neighborhood Hits	471	Target Neighborhood Hits	388	Shared Neighborhood Hits	287
SwissProt Accessions	Q9Z2F6	Gene names	Bcl3
Domain Architecture	No domain graphic available
Description	B-cell lymphoma 3-encoded protein homolog (Protein Bcl-3).

ANR42_MOUSE
NC score	0.873640 (rank : 31)	θ value	9.24701e-21 (rank : 35)
Query Neighborhood Hits	471	Target Neighborhood Hits	334	Shared Neighborhood Hits	285
SwissProt Accessions	Q3V096, Q8BX55, Q8BZT3, Q8C0T6, Q8C0X5	Gene names	Ankrd42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

ASB2_HUMAN
NC score	0.873401 (rank : 32)	θ value	1.29031e-22 (rank : 27)
Query Neighborhood Hits	471	Target Neighborhood Hits	309	Shared Neighborhood Hits	291
SwissProt Accessions	Q96Q27, Q9NSU5, Q9Y567	Gene names	ASB2
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 2 (ASB-2).

ANR23_HUMAN
NC score	0.869619 (rank : 33)	θ value	6.41864e-14 (rank : 100)
Query Neighborhood Hits	471	Target Neighborhood Hits	291	Shared Neighborhood Hits	286
SwissProt Accessions	Q86SG2, Q711K7, Q8NAJ7	Gene names	ANKRD23, DARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein) (Muscle ankyrin repeat protein 3).

ANK3_HUMAN
NC score	0.868977 (rank : 34)	θ value	1.20211e-36 (rank : 5)
Query Neighborhood Hits	471	Target Neighborhood Hits	853	Shared Neighborhood Hits	310
SwissProt Accessions	Q12955	Gene names	ANK3
Domain Architecture
Description	Ankyrin-3 (ANK-3) (Ankyrin-G).

ANR23_MOUSE
NC score	0.868790 (rank : 35)	θ value	4.16044e-13 (rank : 112)
Query Neighborhood Hits	471	Target Neighborhood Hits	296	Shared Neighborhood Hits	286
SwissProt Accessions	Q812A3	Gene names	Ankrd23, Darp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 23 (Diabetes-related ankyrin repeat protein).

ANKR1_MOUSE
NC score	0.868751 (rank : 36)	θ value	5.25075e-16 (rank : 83)
Query Neighborhood Hits	471	Target Neighborhood Hits	316	Shared Neighborhood Hits	289
SwissProt Accessions	Q9CR42, O55014, Q3UIF7, Q3UJ39, Q792Q9	Gene names	Ankrd1, Carp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein).

ANKR1_HUMAN
NC score	0.868692 (rank : 37)	θ value	6.85773e-16 (rank : 86)
Query Neighborhood Hits	471	Target Neighborhood Hits	308	Shared Neighborhood Hits	282
SwissProt Accessions	Q15327, Q96LE7	Gene names	ANKRD1, C193, CARP, HA1A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) (Cytokine-inducible nuclear protein) (C-193).

ASB10_HUMAN
NC score	0.868668 (rank : 38)	θ value	1.99529e-15 (rank : 94)
Query Neighborhood Hits	471	Target Neighborhood Hits	291	Shared Neighborhood Hits	285
SwissProt Accessions	Q8WXI3	Gene names	ASB10
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

ANR42_HUMAN
NC score	0.868664 (rank : 39)	θ value	2.13179e-17 (rank : 64)
Query Neighborhood Hits	471	Target Neighborhood Hits	284	Shared Neighborhood Hits	276
SwissProt Accessions	Q8N9B4, Q49A49	Gene names	ANKRD42
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 42.

ASB2_MOUSE
NC score	0.868291 (rank : 40)	θ value	1.09232e-21 (rank : 30)
Query Neighborhood Hits	471	Target Neighborhood Hits	321	Shared Neighborhood Hits	290
SwissProt Accessions	Q8K0L0, Q9CTH4, Q9WV73	Gene names	Asb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 2 (ASB-2).

ASB10_MOUSE
NC score	0.868205 (rank : 41)	θ value	4.74913e-17 (rank : 67)
Query Neighborhood Hits	471	Target Neighborhood Hits	301	Shared Neighborhood Hits	286
SwissProt Accessions	Q91ZT7	Gene names	Asb10
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 10 (ASB-10).

INVS_MOUSE
NC score	0.866831 (rank : 42)	θ value	3.17815e-21 (rank : 32)
Query Neighborhood Hits	471	Target Neighborhood Hits	609	Shared Neighborhood Hits	294
SwissProt Accessions	O89019, O88849	Gene names	Invs, Inv, Nphp2
Domain Architecture	No domain graphic available
Description	Inversin (Inversion of embryo turning protein) (Nephrocystin-2).

ASB8_MOUSE
NC score	0.866054 (rank : 43)	θ value	2.88119e-14 (rank : 99)
Query Neighborhood Hits	471	Target Neighborhood Hits	293	Shared Neighborhood Hits	284
SwissProt Accessions	Q91ZT9, Q8R178	Gene names	Asb8
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 8 (ASB-8).

PA2G6_MOUSE
NC score	0.865588 (rank : 44)	θ value	6.62687e-19 (rank : 49)
Query Neighborhood Hits	471	Target Neighborhood Hits	293	Shared Neighborhood Hits	290
SwissProt Accessions	P97819, Q99LA9, Q9JK61	Gene names	Pla2g6
Domain Architecture
Description	85 kDa calcium-independent phospholipase A2 (EC 3.1.1.4) (iPLA2) (CaI- PLA2) (Group VI phospholipase A2) (GVI PLA2).

ASB8_HUMAN
NC score	0.864038 (rank : 45)	θ value	6.41864e-14 (rank : 101)
Query Neighborhood Hits	471	Target Neighborhood Hits	294	Shared Neighborhood Hits	287
SwissProt Accessions	Q9H765, Q547Q2	Gene names	ASB8
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 8 (ASB-8).

TRPA1_MOUSE
NC score	0.862475 (rank : 46)	θ value	2.27762e-19 (rank : 47)
Query Neighborhood Hits	471	Target Neighborhood Hits	343	Shared Neighborhood Hits	296
SwissProt Accessions	Q8BLA8	Gene names	Trpa1, Anktm1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1).

PA2G6_HUMAN
NC score	0.861178 (rank : 47)	θ value	7.32683e-18 (rank : 60)
Query Neighborhood Hits	471	Target Neighborhood Hits	284	Shared Neighborhood Hits	281
SwissProt Accessions	O60733, O75645, Q8N452, Q9UG29, Q9UIT0, Q9Y671	Gene names	PLA2G6, IPLA2
Domain Architecture
Description	85 kDa calcium-independent phospholipase A2 (EC 3.1.1.4) (iPLA2) (CaI- PLA2) (Group VI phospholipase A2) (GVI PLA2).

ANKR7_HUMAN
NC score	0.860139 (rank : 48)	θ value	6.20254e-17 (rank : 70)
Query Neighborhood Hits	471	Target Neighborhood Hits	286	Shared Neighborhood Hits	281
SwissProt Accessions	Q92527, Q96QN1, Q9UDM3	Gene names	ANKRD7
Domain Architecture
Description	Ankyrin repeat domain-containing protein 7 (Testis-specific protein TSA806).

ANR39_HUMAN
NC score	0.859846 (rank : 49)	θ value	1.02475e-11 (rank : 128)
Query Neighborhood Hits	471	Target Neighborhood Hits	285	Shared Neighborhood Hits	283
SwissProt Accessions	Q53RE8, Q59FU2, Q8N5X5, Q9P0S5	Gene names	ANKRD39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

TRPA1_HUMAN
NC score	0.858436 (rank : 50)	θ value	2.5182e-18 (rank : 55)
Query Neighborhood Hits	471	Target Neighborhood Hits	339	Shared Neighborhood Hits	296
SwissProt Accessions	O75762	Gene names	TRPA1, ANKTM1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation sensitive-protein p120).

ANR39_MOUSE
NC score	0.856595 (rank : 51)	θ value	1.02475e-11 (rank : 129)
Query Neighborhood Hits	471	Target Neighborhood Hits	284	Shared Neighborhood Hits	283
SwissProt Accessions	Q9D2X0	Gene names	Ankrd39
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 39.

ASB13_MOUSE
NC score	0.853618 (rank : 52)	θ value	7.09661e-13 (rank : 116)
Query Neighborhood Hits	471	Target Neighborhood Hits	293	Shared Neighborhood Hits	283
SwissProt Accessions	Q8VBX0	Gene names	Asb13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 13 (ASB-13).

IKBA_HUMAN
NC score	0.853520 (rank : 53)	θ value	4.74913e-17 (rank : 68)
Query Neighborhood Hits	471	Target Neighborhood Hits	280	Shared Neighborhood Hits	278
SwissProt Accessions	P25963	Gene names	NFKBIA, IKBA, MAD3, NFKBI
Domain Architecture
Description	NF-kappa-B inhibitor alpha (Major histocompatibility complex enhancer- binding protein MAD3) (I-kappa-B-alpha) (IkappaBalpha) (IKB-alpha).

ASB13_HUMAN
NC score	0.852512 (rank : 54)	θ value	3.52202e-12 (rank : 124)
Query Neighborhood Hits	471	Target Neighborhood Hits	293	Shared Neighborhood Hits	284
SwissProt Accessions	Q8WXK3, Q96EP7, Q9H8Z1	Gene names	ASB13
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 13 (ASB-13).

IKBE_MOUSE
NC score	0.851676 (rank : 55)	θ value	6.85773e-16 (rank : 87)
Query Neighborhood Hits	471	Target Neighborhood Hits	308	Shared Neighborhood Hits	280
SwissProt Accessions	O54910, Q3U686, Q9CZZ9, Q9D7U3	Gene names	Nfkbie, Ikbe
Domain Architecture
Description	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKB-E).

ANKS1_HUMAN
NC score	0.846178 (rank : 56)	θ value	1.6852e-22 (rank : 28)
Query Neighborhood Hits	471	Target Neighborhood Hits	438	Shared Neighborhood Hits	298
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

GABP3_MOUSE
NC score	0.845969 (rank : 57)	θ value	3.89403e-11 (rank : 133)
Query Neighborhood Hits	471	Target Neighborhood Hits	330	Shared Neighborhood Hits	279
SwissProt Accessions	P81069	Gene names	Gabpb2
Domain Architecture	No domain graphic available
Description	GA-binding protein beta-2-1 chain (GABP subunit beta-2-1) (GABPB2-1).

ANKS6_MOUSE
NC score	0.845226 (rank : 58)	θ value	1.52774e-15 (rank : 91)
Query Neighborhood Hits	471	Target Neighborhood Hits	435	Shared Neighborhood Hits	292
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

ANKS6_HUMAN
NC score	0.845033 (rank : 59)	θ value	1.99529e-15 (rank : 93)
Query Neighborhood Hits	471	Target Neighborhood Hits	411	Shared Neighborhood Hits	293
SwissProt Accessions	Q68DC2, Q5VSL0, Q5VSL2, Q5VSL3, Q5VSL4, Q68DB8, Q6P2R2, Q8N9L6, Q96D62	Gene names	ANKS6, ANKRD14, SAMD6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6) (Ankyrin repeat domain-containing protein 14).

IKBA_MOUSE
NC score	0.843907 (rank : 60)	θ value	5.25075e-16 (rank : 84)
Query Neighborhood Hits	471	Target Neighborhood Hits	283	Shared Neighborhood Hits	278
SwissProt Accessions	Q9Z1E3, Q80ZX5	Gene names	Nfkbia, Ikba
Domain Architecture	No domain graphic available
Description	NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkappaBalpha) (IKB- alpha).

GABP2_MOUSE
NC score	0.843465 (rank : 61)	θ value	4.30538e-10 (rank : 146)
Query Neighborhood Hits	471	Target Neighborhood Hits	429	Shared Neighborhood Hits	288
SwissProt Accessions	Q00420, Q00421, Q8BS31, Q91YZ0, Q9QVV2	Gene names	Gabpb2, Gabpb, Gabpb1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1).

GABP2_HUMAN
NC score	0.842189 (rank : 62)	θ value	1.9326e-10 (rank : 141)
Query Neighborhood Hits	471	Target Neighborhood Hits	454	Shared Neighborhood Hits	288
SwissProt Accessions	Q06547, Q06545, Q12940, Q12941, Q12942, Q8IYD0	Gene names	GABPB2, E4TF1B, GABPB, GABPB1
Domain Architecture
Description	GA-binding protein beta chain (GABP subunit beta-2) (GABP-2) (GABP subunit beta-1) (GABPB-1) (Transcription factor E4TF1-53) (Transcription factor E4TF1-47) (Nuclear respiratory factor 2).

ANKS3_MOUSE
NC score	0.840644 (rank : 63)	θ value	9.26847e-13 (rank : 118)
Query Neighborhood Hits	471	Target Neighborhood Hits	355	Shared Neighborhood Hits	278
SwissProt Accessions	Q9CZK6, Q6ZPF6, Q80X46	Gene names	Anks3, Kiaa1977
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 3.

CDN2C_MOUSE
NC score	0.840198 (rank : 64)	θ value	1.133e-10 (rank : 136)
Query Neighborhood Hits	471	Target Neighborhood Hits	270	Shared Neighborhood Hits	267
SwissProt Accessions	Q60772	Gene names	Cdkn2c
Domain Architecture
Description	Cyclin-dependent kinase 6 inhibitor (p18-INK6) (Cyclin-dependent kinase 4 inhibitor C) (p18-INK4c).

CDN2C_HUMAN
NC score	0.840086 (rank : 65)	θ value	1.47974e-10 (rank : 138)
Query Neighborhood Hits	471	Target Neighborhood Hits	262	Shared Neighborhood Hits	262
SwissProt Accessions	P42773, Q8TB83	Gene names	CDKN2C, CDKN6
Domain Architecture
Description	Cyclin-dependent kinase 6 inhibitor (p18-INK6) (Cyclin-dependent kinase 4 inhibitor C) (p18-INK4c).

ANKS3_HUMAN
NC score	0.838908 (rank : 66)	θ value	2.0648e-12 (rank : 121)
Query Neighborhood Hits	471	Target Neighborhood Hits	355	Shared Neighborhood Hits	279
SwissProt Accessions	Q6ZW76, Q8TF25	Gene names	ANKS3, KIAA1977
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 3.

ANR49_MOUSE
NC score	0.837382 (rank : 67)	θ value	2.36244e-08 (rank : 177)
Query Neighborhood Hits	471	Target Neighborhood Hits	285	Shared Neighborhood Hits	278
SwissProt Accessions	Q8VE42, Q9Z2S1	Gene names	Ankrd49, Fgif, Gbif
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor) (Fetal globin-increasing factor).

ASB15_HUMAN
NC score	0.836075 (rank : 68)	θ value	1.68911e-14 (rank : 98)
Query Neighborhood Hits	471	Target Neighborhood Hits	305	Shared Neighborhood Hits	282
SwissProt Accessions	Q8WXK1	Gene names	ASB15
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 15 (ASB-15).

PP16A_MOUSE
NC score	0.835885 (rank : 69)	θ value	1.16975e-15 (rank : 90)
Query Neighborhood Hits	471	Target Neighborhood Hits	318	Shared Neighborhood Hits	283
SwissProt Accessions	Q923M0, Q4V9Z1	Gene names	Ppp1r16a, Mypt3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase targeting subunit 3).

ASB16_MOUSE
NC score	0.835252 (rank : 70)	θ value	4.76016e-09 (rank : 160)
Query Neighborhood Hits	471	Target Neighborhood Hits	306	Shared Neighborhood Hits	284
SwissProt Accessions	Q8VHS5, Q8BYT0	Gene names	Asb16
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 16 (ASB-16).

IKBE_HUMAN
NC score	0.833738 (rank : 71)	θ value	3.40345e-15 (rank : 95)
Query Neighborhood Hits	471	Target Neighborhood Hits	288	Shared Neighborhood Hits	270
SwissProt Accessions	O00221	Gene names	NFKBIE, IKBE
Domain Architecture
Description	NF-kappa-B inhibitor epsilon (NF-kappa-BIE) (I-kappa-B-epsilon) (IkappaBepsilon) (IKB-epsilon) (IKBE).

AN36B_HUMAN
NC score	0.833356 (rank : 72)	θ value	1.2105e-12 (rank : 120)
Query Neighborhood Hits	471	Target Neighborhood Hits	294	Shared Neighborhood Hits	287
SwissProt Accessions	Q8N2N9, Q6IPR0	Gene names	ANKRD36B
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 36B.

MYPT1_MOUSE
NC score	0.832597 (rank : 73)	θ value	1.52774e-15 (rank : 92)
Query Neighborhood Hits	471	Target Neighborhood Hits	539	Shared Neighborhood Hits	292
SwissProt Accessions	Q9DBR7, Q8CBV2, Q99NB6	Gene names	Ppp1r12a, Mypt1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1).

ASZ1_HUMAN
NC score	0.831403 (rank : 74)	θ value	7.09661e-13 (rank : 117)
Query Neighborhood Hits	471	Target Neighborhood Hits	341	Shared Neighborhood Hits	281
SwissProt Accessions	Q8WWH4	Gene names	ASZ1, GASZ
Domain Architecture
Description	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).

ANR49_HUMAN
NC score	0.831107 (rank : 75)	θ value	1.99992e-07 (rank : 195)
Query Neighborhood Hits	471	Target Neighborhood Hits	282	Shared Neighborhood Hits	275
SwissProt Accessions	Q8WVL7, Q8NDF2, Q96JE5, Q9NXK7	Gene names	ANKRD49, FGIF
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 49 (Fetal globin-inducing factor).

ASB16_HUMAN
NC score	0.830508 (rank : 76)	θ value	3.64472e-09 (rank : 158)
Query Neighborhood Hits	471	Target Neighborhood Hits	286	Shared Neighborhood Hits	273
SwissProt Accessions	Q96NS5, Q8WXK0	Gene names	ASB16
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 16 (ASB-16).

ANKS1_MOUSE
NC score	0.830377 (rank : 77)	θ value	5.07402e-19 (rank : 48)
Query Neighborhood Hits	471	Target Neighborhood Hits	453	Shared Neighborhood Hits	296
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

PP16A_HUMAN
NC score	0.828240 (rank : 78)	θ value	4.16044e-13 (rank : 114)
Query Neighborhood Hits	471	Target Neighborhood Hits	340	Shared Neighborhood Hits	278
SwissProt Accessions	Q96I34	Gene names	PPP1R16A, MYPT3
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 16A (Myosin phosphatase- targeting subunit 3).

ASZ1_MOUSE
NC score	0.828020 (rank : 79)	θ value	3.29651e-10 (rank : 144)
Query Neighborhood Hits	471	Target Neighborhood Hits	319	Shared Neighborhood Hits	281
SwissProt Accessions	Q8VD46, Q9JKQ7	Gene names	Asz1, Gasz
Domain Architecture
Description	Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (Germ cell-specific ankyrin, SAM and basic leucine zipper domain- containing protein).

CDN2D_HUMAN
NC score	0.827623 (rank : 80)	θ value	1.47974e-10 (rank : 139)
Query Neighborhood Hits	471	Target Neighborhood Hits	268	Shared Neighborhood Hits	267
SwissProt Accessions	P55273, Q13102, Q6FGE9	Gene names	CDKN2D
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

PP16B_HUMAN
NC score	0.825809 (rank : 81)	θ value	2.43908e-13 (rank : 109)
Query Neighborhood Hits	471	Target Neighborhood Hits	307	Shared Neighborhood Hits	281
SwissProt Accessions	Q96T49, O94912, Q9NQG4	Gene names	PPP1R16B, ANKRD4, KIAA0823
Domain Architecture
Description	Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta- inhibited membrane-associated protein) (hTIMAP) (CAAX box protein TIMAP) (Ankyrin repeat domain protein 4).

ASB14_MOUSE
NC score	0.825579 (rank : 82)	θ value	2.43908e-13 (rank : 108)
Query Neighborhood Hits	471	Target Neighborhood Hits	293	Shared Neighborhood Hits	276
SwissProt Accessions	Q8VHS7	Gene names	Asb14
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 14 (ASB-14).

ANRA2_HUMAN
NC score	0.825251 (rank : 83)	θ value	9.26847e-13 (rank : 119)
Query Neighborhood Hits	471	Target Neighborhood Hits	288	Shared Neighborhood Hits	278
SwissProt Accessions	Q9H9E1	Gene names	ANKRA2, ANKRA
Domain Architecture
Description	Ankyrin repeat family A protein 2 (RFXANK-like 2).

ANR22_HUMAN
NC score	0.824403 (rank : 84)	θ value	6.87365e-08 (rank : 186)
Query Neighborhood Hits	471	Target Neighborhood Hits	243	Shared Neighborhood Hits	243
SwissProt Accessions	Q5VYY1, Q8WU06	Gene names	ANKRD22
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 22.

ASB15_MOUSE
NC score	0.824009 (rank : 85)	θ value	1.86753e-13 (rank : 106)
Query Neighborhood Hits	471	Target Neighborhood Hits	292	Shared Neighborhood Hits	274
SwissProt Accessions	Q8VHS6	Gene names	Asb15
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 15 (ASB-15).

PP16B_MOUSE
NC score	0.823532 (rank : 86)	θ value	3.18553e-13 (rank : 110)
Query Neighborhood Hits	471	Target Neighborhood Hits	302	Shared Neighborhood Hits	281
SwissProt Accessions	Q8VHQ3	Gene names	Ppp1r16b
Domain Architecture
Description	Protein phosphatase 1 regulatory inhibitor subunit 16B (TGF-beta- inhibited membrane-associated protein) (CAAX box protein TIMAP).

RN5A_HUMAN
NC score	0.823481 (rank : 87)	θ value	7.32683e-18 (rank : 61)
Query Neighborhood Hits	471	Target Neighborhood Hits	608	Shared Neighborhood Hits	284
SwissProt Accessions	Q05823	Gene names	RNASEL, RNS4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

ANRA2_MOUSE
NC score	0.822590 (rank : 88)	θ value	1.02475e-11 (rank : 130)
Query Neighborhood Hits	471	Target Neighborhood Hits	287	Shared Neighborhood Hits	278
SwissProt Accessions	Q99PE2	Gene names	Ankra2, Ankra
Domain Architecture
Description	Ankyrin repeat family A protein 2 (RFXANK-like 2).

CDN2D_MOUSE
NC score	0.822036 (rank : 89)	θ value	3.64472e-09 (rank : 159)
Query Neighborhood Hits	471	Target Neighborhood Hits	267	Shared Neighborhood Hits	266
SwissProt Accessions	Q60773, Q60794	Gene names	Cdkn2d
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor D (p19-INK4d).

CSKI2_MOUSE
NC score	0.821515 (rank : 90)	θ value	3.51386e-20 (rank : 40)
Query Neighborhood Hits	471	Target Neighborhood Hits	812	Shared Neighborhood Hits	301
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CSKI2_HUMAN
NC score	0.820794 (rank : 91)	θ value	5.42112e-21 (rank : 33)
Query Neighborhood Hits	471	Target Neighborhood Hits	747	Shared Neighborhood Hits	300
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

MTPN_MOUSE
NC score	0.820744 (rank : 92)	θ value	5.81887e-07 (rank : 202)
Query Neighborhood Hits	471	Target Neighborhood Hits	269	Shared Neighborhood Hits	267
SwissProt Accessions	P62774, P80144, Q543M6, Q9DCN8	Gene names	Mtpn, Gcdp
Domain Architecture	No domain graphic available
Description	Myotrophin (Protein V-1) (Granule cell differentiation protein).

ANKR5_HUMAN
NC score	0.818441 (rank : 93)	θ value	5.26297e-08 (rank : 181)
Query Neighborhood Hits	471	Target Neighborhood Hits	297	Shared Neighborhood Hits	282
SwissProt Accessions	Q9NU02, Q9H6Y9	Gene names	ANKRD5
Domain Architecture
Description	Ankyrin repeat domain-containing protein 5.

ANKR5_MOUSE
NC score	0.817611 (rank : 94)	θ value	5.81887e-07 (rank : 199)
Query Neighborhood Hits	471	Target Neighborhood Hits	298	Shared Neighborhood Hits	283
SwissProt Accessions	Q9D2J7	Gene names	Ankrd5
Domain Architecture
Description	Ankyrin repeat domain-containing protein 5.

MYPT2_HUMAN
NC score	0.817590 (rank : 95)	θ value	6.85773e-16 (rank : 88)
Query Neighborhood Hits	471	Target Neighborhood Hits	707	Shared Neighborhood Hits	292
SwissProt Accessions	O60237, Q8N179, Q9HCB7, Q9HCB8	Gene names	PPP1R12B, MYPT2
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase- targeting subunit 2) (Myosin phosphatase target subunit 2).

CSKI1_HUMAN
NC score	0.817045 (rank : 96)	θ value	1.6852e-22 (rank : 29)
Query Neighborhood Hits	471	Target Neighborhood Hits	997	Shared Neighborhood Hits	299
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

ASB9_HUMAN
NC score	0.816752 (rank : 97)	θ value	5.08577e-11 (rank : 135)
Query Neighborhood Hits	471	Target Neighborhood Hits	267	Shared Neighborhood Hits	257
SwissProt Accessions	Q96DX5, Q9NWS5, Q9Y4T3	Gene names	ASB9
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 9 (ASB-9).

IKBB_MOUSE
NC score	0.816436 (rank : 98)	θ value	1.133e-10 (rank : 137)
Query Neighborhood Hits	471	Target Neighborhood Hits	284	Shared Neighborhood Hits	281
SwissProt Accessions	Q60778, Q9D6L5	Gene names	Nfkbib, Ikbb
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B).

MTPN_HUMAN
NC score	0.815979 (rank : 99)	θ value	1.29631e-06 (rank : 208)
Query Neighborhood Hits	471	Target Neighborhood Hits	269	Shared Neighborhood Hits	267
SwissProt Accessions	P58546	Gene names	MTPN
Domain Architecture
Description	Myotrophin (Protein V-1).

CSKI1_MOUSE
NC score	0.815560 (rank : 100)	θ value	9.87957e-23 (rank : 26)
Query Neighborhood Hits	471	Target Neighborhood Hits	1031	Shared Neighborhood Hits	300
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

ANR19_HUMAN
NC score	0.815262 (rank : 101)	θ value	1.80466e-16 (rank : 78)
Query Neighborhood Hits	471	Target Neighborhood Hits	276	Shared Neighborhood Hits	274
SwissProt Accessions	Q9H560	Gene names	ANKRD19
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 19.

RFXK_HUMAN
NC score	0.814497 (rank : 102)	θ value	3.08544e-08 (rank : 179)
Query Neighborhood Hits	471	Target Neighborhood Hits	282	Shared Neighborhood Hits	267
SwissProt Accessions	O14593, O95839	Gene names	RFXANK, ANKRA1, RFXB
Domain Architecture
Description	DNA-binding protein RFXANK (Regulatory factor X subunit B) (RFX-B) (Ankyrin repeat family A protein 1).

MYPT1_HUMAN
NC score	0.813687 (rank : 103)	θ value	5.25075e-16 (rank : 85)
Query Neighborhood Hits	471	Target Neighborhood Hits	723	Shared Neighborhood Hits	295
SwissProt Accessions	O14974, Q86WU3, Q8NFR6, Q9BYH0	Gene names	PPP1R12A, MBS, MYPT1
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase- targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit).

ANK2_HUMAN
NC score	0.813587 (rank : 104)	θ value	4.27553e-34 (rank : 6)
Query Neighborhood Hits	471	Target Neighborhood Hits	1615	Shared Neighborhood Hits	307
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

EHMT1_HUMAN
NC score	0.813394 (rank : 105)	θ value	3.07829e-16 (rank : 80)
Query Neighborhood Hits	471	Target Neighborhood Hits	417	Shared Neighborhood Hits	296
SwissProt Accessions	Q9H9B1, Q8TCN7, Q96F53, Q96JF1, Q96KH4	Gene names	EHMT1, EUHMTASE1, KIAA1876
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a- like protein 1) (GLP1).

ASB4_MOUSE
NC score	0.812703 (rank : 106)	θ value	2.13673e-09 (rank : 154)
Query Neighborhood Hits	471	Target Neighborhood Hits	265	Shared Neighborhood Hits	260
SwissProt Accessions	Q9WV71	Gene names	Asb4
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 4 (ASB-4).

POTE8_HUMAN
NC score	0.812610 (rank : 107)	θ value	8.38298e-14 (rank : 103)
Query Neighborhood Hits	471	Target Neighborhood Hits	337	Shared Neighborhood Hits	288
SwissProt Accessions	Q6S8J7, Q6S8J6	Gene names	POTE8
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 8.

ASB4_HUMAN
NC score	0.812236 (rank : 108)	θ value	6.21693e-09 (rank : 165)
Query Neighborhood Hits	471	Target Neighborhood Hits	264	Shared Neighborhood Hits	260
SwissProt Accessions	Q9Y574, O14586	Gene names	ASB4
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 4 (ASB-4).

ASB11_MOUSE
NC score	0.811707 (rank : 109)	θ value	1.9326e-10 (rank : 140)
Query Neighborhood Hits	471	Target Neighborhood Hits	271	Shared Neighborhood Hits	258
SwissProt Accessions	Q9CQ31, Q3UJ13, Q9D0V1	Gene names	Asb11
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 11 (ASB-11).

IKBB_HUMAN
NC score	0.811274 (rank : 110)	θ value	5.62301e-10 (rank : 148)
Query Neighborhood Hits	471	Target Neighborhood Hits	284	Shared Neighborhood Hits	278
SwissProt Accessions	Q15653, Q96BJ7	Gene names	NFKBIB, IKBB, TRIP9
Domain Architecture
Description	NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkappaBbeta) (IKB-beta) (IKB-B) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9).

ASB5_HUMAN
NC score	0.809678 (rank : 111)	θ value	5.08577e-11 (rank : 134)
Query Neighborhood Hits	471	Target Neighborhood Hits	283	Shared Neighborhood Hits	271
SwissProt Accessions	Q8WWX0	Gene names	ASB5
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 5 (ASB-5).

ANR10_HUMAN
NC score	0.808968 (rank : 112)	θ value	3.64472e-09 (rank : 157)
Query Neighborhood Hits	471	Target Neighborhood Hits	289	Shared Neighborhood Hits	267
SwissProt Accessions	Q9NXR5	Gene names	ANKRD10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

ASB11_HUMAN
NC score	0.808661 (rank : 113)	θ value	9.59137e-10 (rank : 152)
Query Neighborhood Hits	471	Target Neighborhood Hits	271	Shared Neighborhood Hits	261
SwissProt Accessions	Q8WXH4, Q3SYC4	Gene names	ASB11
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 11 (ASB-11).

BARD1_HUMAN
NC score	0.806538 (rank : 114)	θ value	8.11959e-09 (rank : 166)
Query Neighborhood Hits	471	Target Neighborhood Hits	427	Shared Neighborhood Hits	337
SwissProt Accessions	Q99728, O43574	Gene names	BARD1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

BARD1_MOUSE
NC score	0.806238 (rank : 115)	θ value	1.80886e-08 (rank : 172)
Query Neighborhood Hits	471	Target Neighborhood Hits	411	Shared Neighborhood Hits	331
SwissProt Accessions	O70445	Gene names	Bard1
Domain Architecture
Description	BRCA1-associated RING domain protein 1 (BARD-1).

ANR10_MOUSE
NC score	0.806015 (rank : 116)	θ value	2.36244e-08 (rank : 175)
Query Neighborhood Hits	471	Target Neighborhood Hits	273	Shared Neighborhood Hits	265
SwissProt Accessions	Q99LW0	Gene names	Ankrd10
Domain Architecture
Description	Ankyrin repeat domain-containing protein 10.

EHMT2_HUMAN
NC score	0.805274 (rank : 117)	θ value	1.38178e-16 (rank : 77)
Query Neighborhood Hits	471	Target Neighborhood Hits	498	Shared Neighborhood Hits	297
SwissProt Accessions	Q96KQ7, Q14349, Q6PK06, Q96MH5, Q96QD0, Q9UQL8, Q9Y331	Gene names	EHMT2, BAT8, G9A, NG36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

ASB5_MOUSE
NC score	0.805003 (rank : 118)	θ value	1.63604e-09 (rank : 153)
Query Neighborhood Hits	471	Target Neighborhood Hits	266	Shared Neighborhood Hits	259
SwissProt Accessions	Q9D1A4	Gene names	Asb5
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 5 (ASB-5).

ANR46_HUMAN
NC score	0.804824 (rank : 119)	θ value	2.44474e-05 (rank : 230)
Query Neighborhood Hits	471	Target Neighborhood Hits	281	Shared Neighborhood Hits	276
SwissProt Accessions	Q86W74, Q6P9B7	Gene names	ANKRD46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

ANR35_HUMAN
NC score	0.803907 (rank : 120)	θ value	2.13179e-17 (rank : 63)
Query Neighborhood Hits	471	Target Neighborhood Hits	784	Shared Neighborhood Hits	299
SwissProt Accessions	Q8N283, Q3MJ10, Q96LS3	Gene names	ANKRD35
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 35.

ACBD6_MOUSE
NC score	0.803539 (rank : 121)	θ value	2.36244e-08 (rank : 173)
Query Neighborhood Hits	471	Target Neighborhood Hits	305	Shared Neighborhood Hits	291
SwissProt Accessions	Q9D061, Q3TMN7, Q9DCU4	Gene names	Acbd6
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 6.

RFXK_MOUSE
NC score	0.802008 (rank : 122)	θ value	1.87187e-05 (rank : 226)
Query Neighborhood Hits	471	Target Neighborhood Hits	273	Shared Neighborhood Hits	266
SwissProt Accessions	Q9Z205	Gene names	Rfxank, Rfxb, Tvl1
Domain Architecture
Description	DNA-binding protein RFXANK (Regulatory factor X subunit B) (RFX-B) (Regulatory factor X-associated ankyrin-containing protein) (Ankyrin repeat-containing adapter protein Tvl-1).

ASB9_MOUSE
NC score	0.800959 (rank : 123)	θ value	1.06045e-08 (rank : 169)
Query Neighborhood Hits	471	Target Neighborhood Hits	257	Shared Neighborhood Hits	252
SwissProt Accessions	Q91ZT8, Q9DAF7	Gene names	Asb9
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 9 (ASB-9).

AN36A_HUMAN
NC score	0.799113 (rank : 124)	θ value	2.36244e-08 (rank : 174)
Query Neighborhood Hits	471	Target Neighborhood Hits	271	Shared Neighborhood Hits	270
SwissProt Accessions	Q6UX02, Q86X62	Gene names	ANKRD36, ANKRD36A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 36A.

ACBD6_HUMAN
NC score	0.797698 (rank : 125)	θ value	1.17247e-07 (rank : 190)
Query Neighborhood Hits	471	Target Neighborhood Hits	304	Shared Neighborhood Hits	287
SwissProt Accessions	Q9BR61	Gene names	ACBD6
Domain Architecture	No domain graphic available
Description	Acyl-CoA-binding domain-containing protein 6.

ANR46_MOUSE
NC score	0.797343 (rank : 126)	θ value	4.1701e-05 (rank : 235)
Query Neighborhood Hits	471	Target Neighborhood Hits	274	Shared Neighborhood Hits	269
SwissProt Accessions	Q8BTZ5, Q1LZK9, Q8BV97	Gene names	Ankrd46
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 46 (Ankyrin repeat small protein) (ANK-S).

CT086_HUMAN
NC score	0.796289 (rank : 127)	θ value	0.000786445 (rank : 262)
Query Neighborhood Hits	471	Target Neighborhood Hits	277	Shared Neighborhood Hits	272
SwissProt Accessions	Q9BZ19, Q4VXE6	Gene names	C20orf86
Domain Architecture
Description	Putative uncharacterized protein C20orf86.

ASB1_HUMAN
NC score	0.794246 (rank : 128)	θ value	2.61198e-07 (rank : 196)
Query Neighborhood Hits	471	Target Neighborhood Hits	291	Shared Neighborhood Hits	276
SwissProt Accessions	Q9Y576, Q9ULS4	Gene names	ASB1, KIAA1146
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 1 (ASB-1).

ASB1_MOUSE
NC score	0.792778 (rank : 129)	θ value	3.08544e-08 (rank : 178)
Query Neighborhood Hits	471	Target Neighborhood Hits	292	Shared Neighborhood Hits	276
SwissProt Accessions	Q9WV74	Gene names	Asb1
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 1 (ASB-1).

EHMT2_MOUSE
NC score	0.789382 (rank : 130)	θ value	8.10077e-17 (rank : 74)
Query Neighborhood Hits	471	Target Neighborhood Hits	750	Shared Neighborhood Hits	301
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

ASB12_HUMAN
NC score	0.789008 (rank : 131)	θ value	1.06045e-08 (rank : 168)
Query Neighborhood Hits	471	Target Neighborhood Hits	263	Shared Neighborhood Hits	263
SwissProt Accessions	Q8WXK4, Q52LK4, Q6ISF9	Gene names	ASB12
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 12 (ASB-12).

ANFY1_MOUSE
NC score	0.786965 (rank : 132)	θ value	1.47631e-18 (rank : 53)
Query Neighborhood Hits	471	Target Neighborhood Hits	480	Shared Neighborhood Hits	303
SwissProt Accessions	Q810B6, O54807, Q80TG6, Q80UH8	Gene names	Ankfy1, Ankhzn, Kiaa1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ANFY1_HUMAN
NC score	0.786760 (rank : 133)	θ value	2.7842e-17 (rank : 65)
Query Neighborhood Hits	471	Target Neighborhood Hits	480	Shared Neighborhood Hits	294
SwissProt Accessions	Q9P2R3, Q9ULG5	Gene names	ANKFY1, ANKHZN, KIAA1255
Domain Architecture
Description	Ankyrin repeat and FYVE domain-containing protein 1 (Ankyrin repeats hooked to a zinc finger motif).

ASB12_MOUSE
NC score	0.780503 (rank : 134)	θ value	9.92553e-07 (rank : 204)
Query Neighborhood Hits	471	Target Neighborhood Hits	261	Shared Neighborhood Hits	259
SwissProt Accessions	Q9D738	Gene names	Asb12
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SOCS box protein 12 (ASB-12).

ZDH17_HUMAN
NC score	0.776572 (rank : 135)	θ value	6.62687e-19 (rank : 50)
Query Neighborhood Hits	471	Target Neighborhood Hits	334	Shared Neighborhood Hits	282
SwissProt Accessions	Q8IUH5, O75407, Q7Z2I0, Q86W89, Q86YK0, Q9P088, Q9UPZ8	Gene names	ZDHHC17, HIP14, HIP3, KIAA0946
Domain Architecture
Description	Palmitoyltransferase ZDHHC17 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 17) (DHHC-17) (Huntingtin-interacting protein 14) (Huntingtin-interacting protein 3) (Huntingtin-interacting protein HYPH) (Putative NF-kappa-B-activating protein 205) (Putative MAPK- activating protein PM11).

ANR32_HUMAN
NC score	0.775579 (rank : 136)	θ value	6.87365e-08 (rank : 187)
Query Neighborhood Hits	471	Target Neighborhood Hits	270	Shared Neighborhood Hits	262
SwissProt Accessions	Q9BQI6	Gene names	ANKRD32
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 32.

RN5A_MOUSE
NC score	0.774758 (rank : 137)	θ value	4.58923e-20 (rank : 41)
Query Neighborhood Hits	471	Target Neighborhood Hits	899	Shared Neighborhood Hits	295
SwissProt Accessions	Q05921, Q9ERU7	Gene names	Rnasel, Rns4
Domain Architecture
Description	2-5A-dependent ribonuclease (EC 3.1.26.-) (2-5A-dependent RNase) (Ribonuclease L) (RNase L) (Ribonuclease 4).

ZDH13_HUMAN
NC score	0.771588 (rank : 138)	θ value	5.60996e-18 (rank : 58)
Query Neighborhood Hits	471	Target Neighborhood Hits	322	Shared Neighborhood Hits	279
SwissProt Accessions	Q8IUH4, Q7Z2D3, Q86VK2, Q9NV30, Q9NV99	Gene names	ZDHHC13, HIP14L, HIP3RP
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC13 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 13) (DHHC-13) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein) (Huntingtin- interacting protein HIP3RP) (Putative NF-kappa-B-activating protein 209) (Putative MAPK-activating protein PM03).

ZDH17_MOUSE
NC score	0.771467 (rank : 139)	θ value	1.47631e-18 (rank : 54)
Query Neighborhood Hits	471	Target Neighborhood Hits	328	Shared Neighborhood Hits	276
SwissProt Accessions	Q80TN5, Q8BJ08, Q8BYQ2, Q8BYQ6	Gene names	Zdhhc17, Hip14, Kiaa0946
Domain Architecture
Description	Palmitoyltransferase ZDHHC17 (EC 2.3.1.-) (Zinc finger DHHC domain- containing protein 17) (DHHC-17) (Huntingtin-interacting protein 14).

ZDH13_MOUSE
NC score	0.768881 (rank : 140)	θ value	3.28887e-18 (rank : 56)
Query Neighborhood Hits	471	Target Neighborhood Hits	329	Shared Neighborhood Hits	282
SwissProt Accessions	Q9CWU2, Q3UK32, Q3UKV1	Gene names	Zdhhc13, Hip14l
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC13 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 13) (DHHC-13) (Huntingtin-interacting protein 14-related protein) (HIP14-related protein).

ANR32_MOUSE
NC score	0.766571 (rank : 141)	θ value	1.38499e-08 (rank : 170)
Query Neighborhood Hits	471	Target Neighborhood Hits	285	Shared Neighborhood Hits	262
SwissProt Accessions	Q8R3P9, Q5XK30, Q8BHY5, Q921Y9	Gene names	Ankrd32
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 32.

NFKB1_HUMAN
NC score	0.765901 (rank : 142)	θ value	8.65492e-19 (rank : 52)
Query Neighborhood Hits	471	Target Neighborhood Hits	306	Shared Neighborhood Hits	278
SwissProt Accessions	P19838, Q68D84, Q86V43, Q8N4X7, Q9NZC0	Gene names	NFKB1
Domain Architecture
Description	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) [Contains: Nuclear factor NF-kappa-B p50 subunit].

NFKB1_MOUSE
NC score	0.763678 (rank : 143)	θ value	7.32683e-18 (rank : 59)
Query Neighborhood Hits	471	Target Neighborhood Hits	300	Shared Neighborhood Hits	270
SwissProt Accessions	P25799, Q3TZE8, Q3V2V6, Q6TDG8, Q75ZL1, Q80Y21, Q8C712	Gene names	Nfkb1
Domain Architecture
Description	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP- 1) (NF-kappa-B1 p84/NF-kappa-B1 p98) [Contains: Nuclear factor NF- kappa-B p50 subunit].

ANR21_HUMAN
NC score	0.763410 (rank : 144)	θ value	2.35696e-16 (rank : 79)
Query Neighborhood Hits	471	Target Neighborhood Hits	864	Shared Neighborhood Hits	295
SwissProt Accessions	Q86YR6	Gene names	ANKRD21, POTE
Domain Architecture
Description	Ankyrin repeat domain-containing protein 21 (Protein POTE) (Prostate, ovary, testis-expressed protein).

ASB6_HUMAN
NC score	0.763304 (rank : 145)	θ value	1.17247e-07 (rank : 192)
Query Neighborhood Hits	471	Target Neighborhood Hits	256	Shared Neighborhood Hits	249
SwissProt Accessions	Q9NWX5	Gene names	ASB6
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 6 (ASB-6).

POT15_HUMAN
NC score	0.762606 (rank : 146)	θ value	6.85773e-16 (rank : 89)
Query Neighborhood Hits	471	Target Neighborhood Hits	893	Shared Neighborhood Hits	293
SwissProt Accessions	Q6S5H4, Q6NXN7, Q6S5H7	Gene names	POTE15
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 15.

ASB6_MOUSE
NC score	0.761448 (rank : 147)	θ value	1.17247e-07 (rank : 193)
Query Neighborhood Hits	471	Target Neighborhood Hits	264	Shared Neighborhood Hits	247
SwissProt Accessions	Q91ZU1, Q8VEC6	Gene names	Asb6
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 6 (ASB-6).

NFKB2_HUMAN
NC score	0.760935 (rank : 148)	θ value	4.29542e-18 (rank : 57)
Query Neighborhood Hits	471	Target Neighborhood Hits	325	Shared Neighborhood Hits	283
SwissProt Accessions	Q00653, Q04860, Q9BU75, Q9H471, Q9H472	Gene names	NFKB2, LYT10
Domain Architecture
Description	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10) (Oncogene Lyt-10) (Lyt10) [Contains: Nuclear factor NF-kappa-B p52 subunit].

ANS4B_HUMAN
NC score	0.752944 (rank : 149)	θ value	3.41135e-07 (rank : 198)
Query Neighborhood Hits	471	Target Neighborhood Hits	289	Shared Neighborhood Hits	259
SwissProt Accessions	Q8N8V4	Gene names	ANKS4B, HARP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

CTTB2_HUMAN
NC score	0.747133 (rank : 150)	θ value	1.2077e-20 (rank : 38)
Query Neighborhood Hits	471	Target Neighborhood Hits	1061	Shared Neighborhood Hits	310
SwissProt Accessions	Q8WZ74, O43389, Q7LG11, Q9C0A5	Gene names	CTTNBP2, C7orf8, CORTBP2, KIAA1758
Domain Architecture	No domain graphic available
Description	Cortactin-binding protein 2 (CortBP2).

POT14_HUMAN
NC score	0.746674 (rank : 151)	θ value	2.13673e-09 (rank : 155)
Query Neighborhood Hits	471	Target Neighborhood Hits	403	Shared Neighborhood Hits	272
SwissProt Accessions	Q6S5H5, Q6S5H6, Q6S8J2	Gene names	POTE14
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 14.

NFKB2_MOUSE
NC score	0.746229 (rank : 152)	θ value	2.7842e-17 (rank : 66)
Query Neighborhood Hits	471	Target Neighborhood Hits	326	Shared Neighborhood Hits	279
SwissProt Accessions	Q9WTK5	Gene names	Nfkb2
Domain Architecture
Description	Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) [Contains: Nuclear factor NF-kappa-B p52 subunit].

ANR47_MOUSE
NC score	0.745189 (rank : 153)	θ value	6.21693e-09 (rank : 164)
Query Neighborhood Hits	471	Target Neighborhood Hits	350	Shared Neighborhood Hits	260
SwissProt Accessions	Q9Z1P7	Gene names	Ankrd47, D17Ertd288e, Ng28
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

USH1G_MOUSE
NC score	0.745125 (rank : 154)	θ value	4.1701e-05 (rank : 240)
Query Neighborhood Hits	471	Target Neighborhood Hits	271	Shared Neighborhood Hits	259
SwissProt Accessions	Q80T11, Q80UG0	Gene names	Ush1g, Sans
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein homolog (Scaffold protein containing ankyrin repeats and SAM domain) (Jackson shaker protein).

USH1G_HUMAN
NC score	0.745036 (rank : 155)	θ value	4.1701e-05 (rank : 239)
Query Neighborhood Hits	471	Target Neighborhood Hits	267	Shared Neighborhood Hits	259
SwissProt Accessions	Q495M9, Q8N251	Gene names	USH1G, SANS
Domain Architecture	No domain graphic available
Description	Usher syndrome type-1G protein (Scaffold protein containing ankyrin repeats and SAM domain).

ANKY2_HUMAN
NC score	0.741858 (rank : 156)	θ value	1.43324e-05 (rank : 222)
Query Neighborhood Hits	471	Target Neighborhood Hits	306	Shared Neighborhood Hits	263
SwissProt Accessions	Q8IV38, Q96BL3	Gene names	ANKMY2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and MYND domain-containing protein 2.

ANR15_HUMAN
NC score	0.739691 (rank : 157)	θ value	2.36244e-08 (rank : 176)
Query Neighborhood Hits	471	Target Neighborhood Hits	478	Shared Neighborhood Hits	271
SwissProt Accessions	Q14678, Q5W0W0, Q8IY65, Q8WX74	Gene names	ANKRD15, KANK, KIAA0172
Domain Architecture
Description	Ankyrin repeat domain-containing protein 15 (Kidney ankyrin repeat- containing protein).

ANS4B_MOUSE
NC score	0.738885 (rank : 158)	θ value	2.21117e-06 (rank : 210)
Query Neighborhood Hits	471	Target Neighborhood Hits	294	Shared Neighborhood Hits	255
SwissProt Accessions	Q8K3X6, Q9D8A5	Gene names	Anks4b, Harp
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 4B (Harmonin- interacting ankyrin repeat-containing protein) (Harp).

ANR11_HUMAN
NC score	0.738250 (rank : 159)	θ value	3.29651e-10 (rank : 143)
Query Neighborhood Hits	471	Target Neighborhood Hits	1289	Shared Neighborhood Hits	289
SwissProt Accessions	Q6UB99, Q6NTG1, Q6QMF8	Gene names	ANKRD11, ANCO1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1).

ANR41_HUMAN
NC score	0.733885 (rank : 160)	θ value	0.00102713 (rank : 265)
Query Neighborhood Hits	471	Target Neighborhood Hits	332	Shared Neighborhood Hits	256
SwissProt Accessions	Q8NAG6, Q8N8J8	Gene names	ANKRD41
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 41.

ANR47_HUMAN
NC score	0.721365 (rank : 161)	θ value	1.17247e-07 (rank : 191)
Query Neighborhood Hits	471	Target Neighborhood Hits	369	Shared Neighborhood Hits	253
SwissProt Accessions	Q6NY19, Q6NZI1, Q6ZQR3, Q8IUV2	Gene names	ANKRD47
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 47.

ANKY2_MOUSE
NC score	0.718054 (rank : 162)	θ value	1.09739e-05 (rank : 220)
Query Neighborhood Hits	471	Target Neighborhood Hits	316	Shared Neighborhood Hits	263
SwissProt Accessions	Q3TPE9, Q8BK14, Q8BYW5, Q8R3N4, Q921J1	Gene names	Ankmy2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and MYND domain-containing protein 2.

BCOR_MOUSE
NC score	0.715324 (rank : 163)	θ value	5.26297e-08 (rank : 184)
Query Neighborhood Hits	471	Target Neighborhood Hits	521	Shared Neighborhood Hits	277
SwissProt Accessions	Q8CGN4, Q6PDK5, Q6ZPM3, Q8BKF5, Q8CGN1, Q8CGN2, Q8CGN3	Gene names	Bcor, Kiaa1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

POT22_HUMAN
NC score	0.714388 (rank : 164)	θ value	4.76016e-09 (rank : 163)
Query Neighborhood Hits	471	Target Neighborhood Hits	266	Shared Neighborhood Hits	257
SwissProt Accessions	Q6S545	Gene names	ACTBL1, POTE22
Domain Architecture	No domain graphic available
Description	Prostate, ovary, testis-expressed protein on chromosome 22.

ANR12_HUMAN
NC score	0.710325 (rank : 165)	θ value	3.89403e-11 (rank : 132)
Query Neighborhood Hits	471	Target Neighborhood Hits	1081	Shared Neighborhood Hits	291
SwissProt Accessions	Q6UB98, O94951, Q658K1, Q6QMF7, Q9H231, Q9H784	Gene names	ANKRD12, ANCO2, KIAA0874
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 12 (Ankyrin repeat-containing cofactor 2) (GAC-1 protein).

SHAN1_HUMAN
NC score	0.709802 (rank : 166)	θ value	1.09485e-13 (rank : 105)
Query Neighborhood Hits	471	Target Neighborhood Hits	1041	Shared Neighborhood Hits	280
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

ANR33_MOUSE
NC score	0.706684 (rank : 167)	θ value	0.000786445 (rank : 261)
Query Neighborhood Hits	471	Target Neighborhood Hits	225	Shared Neighborhood Hits	222
SwissProt Accessions	Q8BXP5, Q8BXP4, Q8R1Z1	Gene names	Ankrd33
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

BCOR_HUMAN
NC score	0.706117 (rank : 168)	θ value	5.26297e-08 (rank : 183)
Query Neighborhood Hits	471	Target Neighborhood Hits	609	Shared Neighborhood Hits	279
SwissProt Accessions	Q6W2J9, Q6P4B6, Q7Z2K7, Q8TEB4, Q96DB3, Q9H232, Q9H233, Q9HCJ7, Q9NXF2	Gene names	BCOR, KIAA1575
Domain Architecture	No domain graphic available
Description	BCoR protein (BCL-6 corepressor).

A20A3_HUMAN
NC score	0.705887 (rank : 169)	θ value	1.38178e-16 (rank : 75)
Query Neighborhood Hits	471	Target Neighborhood Hits	692	Shared Neighborhood Hits	281
SwissProt Accessions	Q5VUR7	Gene names	ANKRD20A3
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A3.

A20A2_HUMAN
NC score	0.705377 (rank : 170)	θ value	4.02038e-16 (rank : 81)
Query Neighborhood Hits	471	Target Neighborhood Hits	716	Shared Neighborhood Hits	281
SwissProt Accessions	Q4UJ75	Gene names	ANKRD20A2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A2.

A20A1_HUMAN
NC score	0.704656 (rank : 171)	θ value	8.10077e-17 (rank : 73)
Query Neighborhood Hits	471	Target Neighborhood Hits	698	Shared Neighborhood Hits	280
SwissProt Accessions	Q5TYW2, Q9H0H6	Gene names	ANKRD20A1, ANKRD20A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A1.

ANR37_HUMAN
NC score	0.703504 (rank : 172)	θ value	0.00665767 (rank : 297)
Query Neighborhood Hits	471	Target Neighborhood Hits	247	Shared Neighborhood Hits	245
SwissProt Accessions	Q7Z713	Gene names	ANKRD37, LPR2BP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37 (Low-density lipoprotein receptor-related protein 2-binding protein) (hLrp2bp).

ANR33_HUMAN
NC score	0.702728 (rank : 173)	θ value	5.44631e-05 (rank : 241)
Query Neighborhood Hits	471	Target Neighborhood Hits	215	Shared Neighborhood Hits	212
SwissProt Accessions	Q7Z3H0, Q5K619, Q5K621, Q5K622, Q5K623, Q5K624, Q6ZUN0	Gene names	ANKRD33, C12orf7
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 33.

A20A4_HUMAN
NC score	0.701007 (rank : 174)	θ value	1.38178e-16 (rank : 76)
Query Neighborhood Hits	471	Target Neighborhood Hits	710	Shared Neighborhood Hits	282
SwissProt Accessions	Q5SQ80	Gene names	ANKRD20A4
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 20A4.

ANR25_HUMAN
NC score	0.697834 (rank : 175)	θ value	5.81887e-07 (rank : 200)
Query Neighborhood Hits	471	Target Neighborhood Hits	350	Shared Neighborhood Hits	257
SwissProt Accessions	Q63ZY3, Q3KQZ3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210	Gene names	ANKRD25, KIAA1518, SIP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25 (SRC-1-interacting protein) (SRC1-interacting protein).

SNCAP_HUMAN
NC score	0.696944 (rank : 176)	θ value	0.0431538 (rank : 348)
Query Neighborhood Hits	471	Target Neighborhood Hits	313	Shared Neighborhood Hits	239
SwissProt Accessions	Q9Y6H5	Gene names	SNCAIP
Domain Architecture
Description	Synphilin-1 (Alpha-synuclein-interacting protein).

CLPB_MOUSE
NC score	0.687696 (rank : 177)	θ value	0.00035302 (rank : 254)
Query Neighborhood Hits	471	Target Neighborhood Hits	289	Shared Neighborhood Hits	249
SwissProt Accessions	Q60649	Gene names	Clpb, Skd3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

ANR25_MOUSE
NC score	0.687398 (rank : 178)	θ value	1.53129e-07 (rank : 194)
Query Neighborhood Hits	471	Target Neighborhood Hits	398	Shared Neighborhood Hits	257
SwissProt Accessions	Q8BX02, Q8BLD5, Q91Z35	Gene names	Ankrd25
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25.

MPP8_HUMAN
NC score	0.686927 (rank : 179)	θ value	3.52202e-12 (rank : 125)
Query Neighborhood Hits	471	Target Neighborhood Hits	948	Shared Neighborhood Hits	264
SwissProt Accessions	Q99549, Q86TK3, Q9BTP1	Gene names	MPHOSPH8, MPP8
Domain Architecture	No domain graphic available
Description	M-phase phosphoprotein 8.

CD2A1_MOUSE
NC score	0.684165 (rank : 180)	θ value	4.92598e-06 (rank : 216)
Query Neighborhood Hits	471	Target Neighborhood Hits	206	Shared Neighborhood Hits	201
SwissProt Accessions	P51480, O89088, P97510, P97937, Q6PEA2, Q78E39, Q78E57, Q792X7, Q9QWH6, Q9QWH7, Q9QWH8	Gene names	Cdkn2a, P16ink4a
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 2A, isoforms 1/2 (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4) (p16-INK4a).

ANR37_MOUSE
NC score	0.683982 (rank : 181)	θ value	0.00102713 (rank : 264)
Query Neighborhood Hits	471	Target Neighborhood Hits	237	Shared Neighborhood Hits	235
SwissProt Accessions	Q569N2, Q8CHS0	Gene names	Ankrd37
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 37.

ANR38_HUMAN
NC score	0.683629 (rank : 182)	θ value	5.26297e-08 (rank : 182)
Query Neighborhood Hits	471	Target Neighborhood Hits	443	Shared Neighborhood Hits	242
SwissProt Accessions	Q5T7N3, Q6P9A0, Q86T71, Q86VE6, Q8NAX3	Gene names	ANKRD38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

OSBL1_HUMAN
NC score	0.682062 (rank : 183)	θ value	3.40345e-15 (rank : 96)
Query Neighborhood Hits	471	Target Neighborhood Hits	368	Shared Neighborhood Hits	281
SwissProt Accessions	Q9BXW6, Q9BZF5, Q9NW87	Gene names	OSBPL1A, ORP1, OSBP8, OSBPL1
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

KRIT1_MOUSE
NC score	0.674987 (rank : 184)	θ value	4.1701e-05 (rank : 236)
Query Neighborhood Hits	471	Target Neighborhood Hits	258	Shared Neighborhood Hits	229
SwissProt Accessions	Q6S5J6, Q6VSV2, Q7TPR8, Q8C9Q6, Q9EPY2, Q9ERH0	Gene names	Krit1, Ccm1
Domain Architecture	No domain graphic available
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein homolog).

OSBL1_MOUSE
NC score	0.669585 (rank : 185)	θ value	1.29331e-14 (rank : 97)
Query Neighborhood Hits	471	Target Neighborhood Hits	336	Shared Neighborhood Hits	283
SwissProt Accessions	Q91XL9, O88318, Q3TH97, Q673L8, Q6DFU6	Gene names	Osbpl1a, Orp1, Orp1a
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

KRIT1_HUMAN
NC score	0.666648 (rank : 186)	θ value	2.44474e-05 (rank : 231)
Query Neighborhood Hits	471	Target Neighborhood Hits	258	Shared Neighborhood Hits	222
SwissProt Accessions	O00522, O43894, Q506L6, Q6U276, Q75N19, Q9H180, Q9H264, Q9HAX5	Gene names	KRIT1, CCM1
Domain Architecture
Description	Krev interaction trapped protein 1 (Krev interaction trapped 1) (Cerebral cavernous malformations 1 protein).

ANR38_MOUSE
NC score	0.664273 (rank : 187)	θ value	5.62301e-10 (rank : 147)
Query Neighborhood Hits	471	Target Neighborhood Hits	512	Shared Neighborhood Hits	235
SwissProt Accessions	Q6P9J5, Q8BV03	Gene names	Ankrd38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

RAI14_HUMAN
NC score	0.658242 (rank : 188)	θ value	1.33526e-19 (rank : 46)
Query Neighborhood Hits	471	Target Neighborhood Hits	1367	Shared Neighborhood Hits	324
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

ANR18_HUMAN
NC score	0.655148 (rank : 189)	θ value	1.63225e-17 (rank : 62)
Query Neighborhood Hits	471	Target Neighborhood Hits	1106	Shared Neighborhood Hits	289
SwissProt Accessions	Q8IVF6, Q7Z468	Gene names	ANKRD18A, KIAA2015
Domain Architecture
Description	Ankyrin repeat domain-containing protein 18A.

OSTF1_MOUSE
NC score	0.653727 (rank : 190)	θ value	8.11959e-09 (rank : 167)
Query Neighborhood Hits	471	Target Neighborhood Hits	467	Shared Neighborhood Hits	256
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

OSTF1_HUMAN
NC score	0.635217 (rank : 191)	θ value	8.97725e-08 (rank : 189)
Query Neighborhood Hits	471	Target Neighborhood Hits	466	Shared Neighborhood Hits	254
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

CDN2B_MOUSE
NC score	0.633063 (rank : 192)	θ value	0.00869519 (rank : 304)
Query Neighborhood Hits	471	Target Neighborhood Hits	201	Shared Neighborhood Hits	196
SwissProt Accessions	P55271	Gene names	Cdkn2b
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b).

RAI14_MOUSE
NC score	0.620867 (rank : 193)	θ value	5.99374e-20 (rank : 42)
Query Neighborhood Hits	471	Target Neighborhood Hits	1505	Shared Neighborhood Hits	320
SwissProt Accessions	Q9EP71, Q3URT3, Q6ZPT6	Gene names	Rai14, Kiaa1334, Norpeg
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein) (p125).

HECD1_HUMAN
NC score	0.617230 (rank : 194)	θ value	1.38499e-08 (rank : 171)
Query Neighborhood Hits	471	Target Neighborhood Hits	371	Shared Neighborhood Hits	275
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

ANR43_HUMAN
NC score	0.616929 (rank : 195)	θ value	0.00134147 (rank : 271)
Query Neighborhood Hits	471	Target Neighborhood Hits	209	Shared Neighborhood Hits	200
SwissProt Accessions	Q2M3V2, Q8NAE7	Gene names	ANKRD43
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 43.

ANR43_MOUSE
NC score	0.610474 (rank : 196)	θ value	0.000602161 (rank : 258)
Query Neighborhood Hits	471	Target Neighborhood Hits	214	Shared Neighborhood Hits	203
SwissProt Accessions	Q8BLS7	Gene names	Ankrd43
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 43.

AN30A_HUMAN
NC score	0.609479 (rank : 197)	θ value	2.43908e-13 (rank : 107)
Query Neighborhood Hits	471	Target Neighborhood Hits	1119	Shared Neighborhood Hits	294
SwissProt Accessions	Q9BXX3, Q5W025	Gene names	ANKRD30A
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 30A (NY-BR-1 antigen).

CLPB_HUMAN
NC score	0.598905 (rank : 198)	θ value	0.00102713 (rank : 268)
Query Neighborhood Hits	471	Target Neighborhood Hits	265	Shared Neighborhood Hits	238
SwissProt Accessions	Q9H078, Q8ND11, Q9H8Y0	Gene names	CLPB, SKD3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

CD2A1_HUMAN
NC score	0.597824 (rank : 199)	θ value	0.0736092 (rank : 354)
Query Neighborhood Hits	471	Target Neighborhood Hits	196	Shared Neighborhood Hits	190
SwissProt Accessions	P42771, O95440, Q15191, Q5VVJ5, Q96B52, Q9NP05	Gene names	CDKN2A, CDKN2
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 2A, isoforms 1/2/3 (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4) (p16-INK4a) (p16INK4A) (Multiple tumor suppressor 1) (MTS1).

NUD12_MOUSE
NC score	0.588544 (rank : 200)	θ value	3.19293e-05 (rank : 234)
Query Neighborhood Hits	471	Target Neighborhood Hits	243	Shared Neighborhood Hits	222
SwissProt Accessions	Q9DCN1, Q6PFA5	Gene names	Nudt12
Domain Architecture	No domain graphic available
Description	Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12).

CDN2B_HUMAN
NC score	0.587324 (rank : 201)	θ value	0.0736092 (rank : 355)
Query Neighborhood Hits	471	Target Neighborhood Hits	196	Shared Neighborhood Hits	194
SwissProt Accessions	P42772, Q6FI09	Gene names	CDKN2B, MTS2
Domain Architecture
Description	Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b) (p15INK4B) (Multiple tumor suppressor 2) (MTS2).

ANR40_HUMAN
NC score	0.585749 (rank : 202)	θ value	0.00665767 (rank : 298)
Query Neighborhood Hits	471	Target Neighborhood Hits	224	Shared Neighborhood Hits	199
SwissProt Accessions	Q6AI12, Q96E32	Gene names	ANKRD40
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 40.

ANR45_MOUSE
NC score	0.583952 (rank : 203)	θ value	0.365318 (rank : 384)
Query Neighborhood Hits	471	Target Neighborhood Hits	204	Shared Neighborhood Hits	190
SwissProt Accessions	Q810N6	Gene names	Ankrd45
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 45.

ANR40_MOUSE
NC score	0.583280 (rank : 204)	θ value	0.00509761 (rank : 293)
Query Neighborhood Hits	471	Target Neighborhood Hits	228	Shared Neighborhood Hits	203
SwissProt Accessions	Q5SUE8, Q8R595, Q9CU71	Gene names	Ankrd40
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 40.

ABTB2_HUMAN
NC score	0.582495 (rank : 205)	θ value	2.44474e-05 (rank : 229)
Query Neighborhood Hits	471	Target Neighborhood Hits	391	Shared Neighborhood Hits	240
SwissProt Accessions	Q8N961, Q6MZW4, Q8NB44	Gene names	ABTB2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

ABTB2_MOUSE
NC score	0.577727 (rank : 206)	θ value	3.77169e-06 (rank : 214)
Query Neighborhood Hits	471	Target Neighborhood Hits	414	Shared Neighborhood Hits	240
SwissProt Accessions	Q7TQI7	Gene names	Abtb2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 2.

ANKK1_HUMAN
NC score	0.571756 (rank : 207)	θ value	2.96777e-27 (rank : 18)
Query Neighborhood Hits	471	Target Neighborhood Hits	1075	Shared Neighborhood Hits	297
SwissProt Accessions	Q8NFD2	Gene names	ANKK1, PKK2
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1) (Protein kinase PKK2) (X-kinase) (SgK288).

TRPV6_MOUSE
NC score	0.569138 (rank : 208)	θ value	7.1131e-05 (rank : 246)
Query Neighborhood Hits	471	Target Neighborhood Hits	284	Shared Neighborhood Hits	259
SwissProt Accessions	Q91WD2	Gene names	Trpv6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1).

RIPK4_HUMAN
NC score	0.564975 (rank : 209)	θ value	9.8567e-31 (rank : 13)
Query Neighborhood Hits	471	Target Neighborhood Hits	1094	Shared Neighborhood Hits	300
SwissProt Accessions	P57078, Q96KH0	Gene names	RIPK4, ANKRD3, DIK
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain protein 3) (PKC-delta-interacting protein kinase).

NUD12_HUMAN
NC score	0.561802 (rank : 210)	θ value	5.44631e-05 (rank : 243)
Query Neighborhood Hits	471	Target Neighborhood Hits	222	Shared Neighborhood Hits	201
SwissProt Accessions	Q9BQG2, Q8TAL7	Gene names	NUDT12
Domain Architecture	No domain graphic available
Description	Peroxisomal NADH pyrophosphatase NUDT12 (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12).

ANR45_HUMAN
NC score	0.561437 (rank : 211)	θ value	0.0431538 (rank : 339)
Query Neighborhood Hits	471	Target Neighborhood Hits	201	Shared Neighborhood Hits	185
SwissProt Accessions	Q5TZF3, Q6ZST1	Gene names	ANKRD45
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 45.

ANKK1_MOUSE
NC score	0.556957 (rank : 212)	θ value	9.54697e-26 (rank : 20)
Query Neighborhood Hits	471	Target Neighborhood Hits	1072	Shared Neighborhood Hits	296
SwissProt Accessions	Q8BZ25	Gene names	Ankk1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and protein kinase domain-containing protein 1 (EC 2.7.11.1).

ASPP2_HUMAN
NC score	0.556656 (rank : 213)	θ value	1.09739e-05 (rank : 221)
Query Neighborhood Hits	471	Target Neighborhood Hits	1156	Shared Neighborhood Hits	285
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

ANKY1_HUMAN
NC score	0.549639 (rank : 214)	θ value	0.0330416 (rank : 330)
Query Neighborhood Hits	471	Target Neighborhood Hits	248	Shared Neighborhood Hits	207
SwissProt Accessions	Q9P2S6, Q8IYX5, Q8NDK5, Q9NX10	Gene names	ANKMY1, TSAL1, ZMYND13
Domain Architecture
Description	Ankyrin repeat and MYND domain-containing protein 1 (Testis-specific ankyrin-like protein 1) (Zinc-finger MYND domain-containing protein 13).

IASPP_HUMAN
NC score	0.545525 (rank : 215)	θ value	0.00134147 (rank : 273)
Query Neighborhood Hits	471	Target Neighborhood Hits	688	Shared Neighborhood Hits	259
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ASPP1_HUMAN
NC score	0.540657 (rank : 216)	θ value	1.29631e-06 (rank : 205)
Query Neighborhood Hits	471	Target Neighborhood Hits	956	Shared Neighborhood Hits	271
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASB14_HUMAN
NC score	0.536374 (rank : 217)	θ value	0.21417 (rank : 372)
Query Neighborhood Hits	471	Target Neighborhood Hits	187	Shared Neighborhood Hits	175
SwissProt Accessions	Q8WXK2	Gene names	ASB14
Domain Architecture
Description	Ankyrin repeat and SOCS box protein 14 (ASB-14).

CENB5_HUMAN
NC score	0.530898 (rank : 218)	θ value	0.00102713 (rank : 266)
Query Neighborhood Hits	471	Target Neighborhood Hits	395	Shared Neighborhood Hits	261
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

GLSL_HUMAN
NC score	0.523563 (rank : 219)	θ value	0.00298849 (rank : 285)
Query Neighborhood Hits	471	Target Neighborhood Hits	211	Shared Neighborhood Hits	202
SwissProt Accessions	Q9UI32, Q9NYY2, Q9UI31	Gene names	GLS2, GA
Domain Architecture
Description	Glutaminase liver isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (L-glutaminase).

ASPP1_MOUSE
NC score	0.522796 (rank : 220)	θ value	1.29631e-06 (rank : 206)
Query Neighborhood Hits	471	Target Neighborhood Hits	1244	Shared Neighborhood Hits	274
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ILK2_HUMAN
NC score	0.522155 (rank : 221)	θ value	4.76016e-09 (rank : 162)
Query Neighborhood Hits	471	Target Neighborhood Hits	848	Shared Neighborhood Hits	285
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

CENB1_HUMAN
NC score	0.522035 (rank : 222)	θ value	0.0330416 (rank : 332)
Query Neighborhood Hits	471	Target Neighborhood Hits	383	Shared Neighborhood Hits	256
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

AN13B_MOUSE
NC score	0.521911 (rank : 223)	θ value	0.000602161 (rank : 257)
Query Neighborhood Hits	471	Target Neighborhood Hits	276	Shared Neighborhood Hits	252
SwissProt Accessions	Q5F259, Q6IR40	Gene names	Ankrd13b
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13B.

AN13B_HUMAN
NC score	0.521484 (rank : 224)	θ value	0.000602161 (rank : 256)
Query Neighborhood Hits	471	Target Neighborhood Hits	265	Shared Neighborhood Hits	252
SwissProt Accessions	Q86YJ7, Q8N7S9	Gene names	ANKRD13B
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13B.

UACA_HUMAN
NC score	0.518071 (rank : 225)	θ value	3.18553e-13 (rank : 111)
Query Neighborhood Hits	471	Target Neighborhood Hits	1622	Shared Neighborhood Hits	321
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

TRPV5_MOUSE
NC score	0.517583 (rank : 226)	θ value	7.1131e-05 (rank : 245)
Query Neighborhood Hits	471	Target Neighborhood Hits	278	Shared Neighborhood Hits	252
SwissProt Accessions	P69744	Gene names	Trpv5
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC1) (Calcium transport protein 2) (CaT2).

CENB2_HUMAN
NC score	0.514371 (rank : 227)	θ value	0.00390308 (rank : 288)
Query Neighborhood Hits	471	Target Neighborhood Hits	425	Shared Neighborhood Hits	251
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

GLSL_MOUSE
NC score	0.513799 (rank : 228)	θ value	0.00228821 (rank : 281)
Query Neighborhood Hits	471	Target Neighborhood Hits	212	Shared Neighborhood Hits	203
SwissProt Accessions	Q571F8	Gene names	Gls2, Kiaa4146
Domain Architecture	No domain graphic available
Description	Glutaminase liver isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (L-glutaminase).

AN13C_HUMAN
NC score	0.508241 (rank : 229)	θ value	0.0148317 (rank : 314)
Query Neighborhood Hits	471	Target Neighborhood Hits	241	Shared Neighborhood Hits	236
SwissProt Accessions	Q8N6S4, Q5VYH4, Q5VYH5, Q6PJE4, Q9H0N9	Gene names	ANKRD13C
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13C.

ILK1_HUMAN
NC score	0.504421 (rank : 230)	θ value	4.76016e-09 (rank : 161)
Query Neighborhood Hits	471	Target Neighborhood Hits	857	Shared Neighborhood Hits	285
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK_MOUSE
NC score	0.502806 (rank : 231)	θ value	2.79066e-09 (rank : 156)
Query Neighborhood Hits	471	Target Neighborhood Hits	858	Shared Neighborhood Hits	283
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

AN13C_MOUSE
NC score	0.498452 (rank : 232)	θ value	0.0148317 (rank : 315)
Query Neighborhood Hits	471	Target Neighborhood Hits	242	Shared Neighborhood Hits	234
SwissProt Accessions	Q3UX43, Q6P1G4	Gene names	Ankrd13c
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13C.

TRPV5_HUMAN
NC score	0.494230 (rank : 233)	θ value	7.1131e-05 (rank : 244)
Query Neighborhood Hits	471	Target Neighborhood Hits	261	Shared Neighborhood Hits	230
SwissProt Accessions	Q9NQA5, Q8NDW5, Q8NDX7, Q8NDX8, Q96PM6	Gene names	TRPV5, ECAC1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Calcium transport protein 2) (CaT2).

TRPV6_HUMAN
NC score	0.493715 (rank : 234)	θ value	4.1701e-05 (rank : 238)
Query Neighborhood Hits	471	Target Neighborhood Hits	262	Shared Neighborhood Hits	232
SwissProt Accessions	Q9H1D0, Q8TDL3, Q8WXR8, Q96LC5, Q9H1D1, Q9H296	Gene names	TRPV6, ECAC2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1) (CaT-like) (CaT-L).

UACA_MOUSE
NC score	0.491756 (rank : 235)	θ value	4.16044e-13 (rank : 115)
Query Neighborhood Hits	471	Target Neighborhood Hits	1620	Shared Neighborhood Hits	317
SwissProt Accessions	Q8CGB3, Q69ZG3, Q7TN77, Q8BJC8	Gene names	Uaca, Kiaa1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein (Nucling) (Nuclear membrane-binding protein).

IASPP_MOUSE
NC score	0.490046 (rank : 236)	θ value	0.00665767 (rank : 300)
Query Neighborhood Hits	471	Target Neighborhood Hits	1024	Shared Neighborhood Hits	260
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ANR26_MOUSE
NC score	0.487172 (rank : 237)	θ value	4.02038e-16 (rank : 82)
Query Neighborhood Hits	471	Target Neighborhood Hits	1554	Shared Neighborhood Hits	316
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

GIT2_MOUSE
NC score	0.482712 (rank : 238)	θ value	0.00665767 (rank : 299)
Query Neighborhood Hits	471	Target Neighborhood Hits	323	Shared Neighborhood Hits	252
SwissProt Accessions	Q9JLQ2	Gene names	Git2
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT2) (CAT-2).

GLSK_HUMAN
NC score	0.474972 (rank : 239)	θ value	0.00298849 (rank : 284)
Query Neighborhood Hits	471	Target Neighborhood Hits	204	Shared Neighborhood Hits	190
SwissProt Accessions	O94925, Q9UL05, Q9UL06, Q9UL07, Q9UN40	Gene names	GLS, GLS1, KIAA0838
Domain Architecture
Description	Glutaminase kidney isoform, mitochondrial precursor (EC 3.5.1.2) (GLS) (L-glutamine amidohydrolase) (K-glutaminase).

ANR26_HUMAN
NC score	0.467520 (rank : 240)	θ value	2.69671e-12 (rank : 122)
Query Neighborhood Hits	471	Target Neighborhood Hits	1614	Shared Neighborhood Hits	324
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

DDFL1_MOUSE
NC score	0.464261 (rank : 241)	θ value	2.88788e-06 (rank : 212)
Query Neighborhood Hits	471	Target Neighborhood Hits	324	Shared Neighborhood Hits	248
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

NOTC4_MOUSE
NC score	0.463857 (rank : 242)	θ value	2.69671e-12 (rank : 123)
Query Neighborhood Hits	471	Target Neighborhood Hits	872	Shared Neighborhood Hits	290
SwissProt Accessions	P31695, O35442, O88314, O88316, Q62389, Q62390, Q9R1W9, Q9R1X0	Gene names	Notch4, Int-3, Int3
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) [Contains: Transforming protein Int-3; Notch 4 extracellular truncation; Notch 4 intracellular domain].

GIT1_MOUSE
NC score	0.463097 (rank : 243)	θ value	0.62314 (rank : 392)
Query Neighborhood Hits	471	Target Neighborhood Hits	341	Shared Neighborhood Hits	246
SwissProt Accessions	Q68FF6	Gene names	Git1
Domain Architecture	No domain graphic available
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1).

AN13A_HUMAN
NC score	0.462476 (rank : 244)	θ value	0.00175202 (rank : 275)
Query Neighborhood Hits	471	Target Neighborhood Hits	243	Shared Neighborhood Hits	223
SwissProt Accessions	Q8IZ07, O60736	Gene names	ANKRD13A, ANKRD13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13A (Protein KE03).

GIT1_HUMAN
NC score	0.461665 (rank : 245)	θ value	0.62314 (rank : 391)
Query Neighborhood Hits	471	Target Neighborhood Hits	336	Shared Neighborhood Hits	245
SwissProt Accessions	Q9Y2X7, Q86SS0, Q9BRJ4	Gene names	GIT1
Domain Architecture
Description	ARF GTPase-activating protein GIT1 (G protein-coupled receptor kinase- interactor 1) (GRK-interacting protein 1) (Cool-associated and tyrosine-phosphorylated protein 1) (Cat-1).

NOTC4_HUMAN
NC score	0.457633 (rank : 246)	θ value	2.98157e-11 (rank : 131)
Query Neighborhood Hits	471	Target Neighborhood Hits	905	Shared Neighborhood Hits	296
SwissProt Accessions	Q99466, O00306, Q99458, Q99940, Q9H3S8, Q9UII9, Q9UIJ0	Gene names	NOTCH4
Domain Architecture
Description	Neurogenic locus notch homolog protein 4 precursor (Notch 4) (hNotch4) [Contains: Notch 4 extracellular truncation; Notch 4 intracellular domain].

CT012_MOUSE
NC score	0.451820 (rank : 247)	θ value	0.0113563 (rank : 309)
Query Neighborhood Hits	471	Target Neighborhood Hits	229	Shared Neighborhood Hits	179
SwissProt Accessions	Q8C008, Q8C060	Gene names
Domain Architecture	No domain graphic available
Description	Protein C20orf12 homolog.

AN13A_MOUSE
NC score	0.444139 (rank : 248)	θ value	0.000158464 (rank : 251)
Query Neighborhood Hits	471	Target Neighborhood Hits	226	Shared Neighborhood Hits	216
SwissProt Accessions	Q80UP5, Q2VPQ7, Q6P7F2	Gene names	Ankrd13a, Ankrd13
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 13A.

TNI3K_HUMAN
NC score	0.443914 (rank : 249)	θ value	4.74913e-17 (rank : 69)
Query Neighborhood Hits	471	Target Neighborhood Hits	1084	Shared Neighborhood Hits	299
SwissProt Accessions	Q59H18, Q49AR1, Q6MZS9, Q9Y2V6	Gene names	TNNI3K, CARK
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

GIT2_HUMAN
NC score	0.442763 (rank : 250)	θ value	0.0330416 (rank : 333)
Query Neighborhood Hits	471	Target Neighborhood Hits	381	Shared Neighborhood Hits	245
SwissProt Accessions	Q14161, Q86U59, Q96CI2, Q9BV91, Q9Y5V2	Gene names	GIT2, KIAA0148
Domain Architecture
Description	ARF GTPase-activating protein GIT2 (G protein-coupled receptor kinase- interactor 2) (GRK-interacting protein 2) (Cool-interacting tyrosine- phosphorylated protein 2) (CAT2) (CAT-2).

TNI3K_MOUSE
NC score	0.442751 (rank : 251)	θ value	7.56453e-23 (rank : 25)
Query Neighborhood Hits	471	Target Neighborhood Hits	1079	Shared Neighborhood Hits	300
SwissProt Accessions	Q5GIG6, Q5GIG5	Gene names	Tnni3k, Cark
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (TNNI3- interacting kinase) (Cardiac ankyrin repeat kinase).

NOTC3_MOUSE
NC score	0.419116 (rank : 252)	θ value	5.62301e-10 (rank : 151)
Query Neighborhood Hits	471	Target Neighborhood Hits	975	Shared Neighborhood Hits	294
SwissProt Accessions	Q61982	Gene names	Notch3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

NOTC1_HUMAN
NC score	0.418067 (rank : 253)	θ value	6.41864e-14 (rank : 102)
Query Neighborhood Hits	471	Target Neighborhood Hits	906	Shared Neighborhood Hits	289
SwissProt Accessions	P46531	Gene names	NOTCH1, TAN1
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

NOTC3_HUMAN
NC score	0.416607 (rank : 254)	θ value	5.62301e-10 (rank : 150)
Query Neighborhood Hits	471	Target Neighborhood Hits	1062	Shared Neighborhood Hits	293
SwissProt Accessions	Q9UM47, Q9UEB3, Q9UPL3, Q9Y6L8	Gene names	NOTCH3
Domain Architecture
Description	Neurogenic locus notch homolog protein 3 precursor (Notch 3) [Contains: Notch 3 extracellular truncation; Notch 3 intracellular domain].

CT012_HUMAN
NC score	0.415893 (rank : 255)	θ value	0.0961366 (rank : 359)
Query Neighborhood Hits	471	Target Neighborhood Hits	205	Shared Neighborhood Hits	168
SwissProt Accessions	Q9NVP4, Q4F7X1, Q5QPD9, Q5QPE0, Q68DN8, Q6ZMX9, Q96NF0, Q9H1E0, Q9H442	Gene names	C20orf12
Domain Architecture
Description	Protein C20orf12.

NOTC2_HUMAN
NC score	0.414612 (rank : 256)	θ value	4.59992e-12 (rank : 126)
Query Neighborhood Hits	471	Target Neighborhood Hits	1113	Shared Neighborhood Hits	292
SwissProt Accessions	Q04721, Q99734, Q9H240	Gene names	NOTCH2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (hN2) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

NOTC2_MOUSE
NC score	0.412311 (rank : 257)	θ value	4.59992e-12 (rank : 127)
Query Neighborhood Hits	471	Target Neighborhood Hits	1069	Shared Neighborhood Hits	289
SwissProt Accessions	O35516, Q06008, Q60941	Gene names	Notch2
Domain Architecture
Description	Neurogenic locus notch homolog protein 2 precursor (Notch 2) (Motch B) [Contains: Notch 2 extracellular truncation; Notch 2 intracellular domain].

DAPK1_MOUSE
NC score	0.408151 (rank : 258)	θ value	8.91499e-32 (rank : 11)
Query Neighborhood Hits	471	Target Neighborhood Hits	1138	Shared Neighborhood Hits	295
SwissProt Accessions	Q80YE7, Q80YE6, Q8R341, Q8VDN6, Q9CSD4, Q9JJP7	Gene names	Dapk1
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

DAPK1_HUMAN
NC score	0.399856 (rank : 259)	θ value	1.52067e-31 (rank : 12)
Query Neighborhood Hits	471	Target Neighborhood Hits	1130	Shared Neighborhood Hits	292
SwissProt Accessions	P53355, Q9BTL8	Gene names	DAPK1, DAPK
Domain Architecture
Description	Death-associated protein kinase 1 (EC 2.7.11.1) (DAP kinase 1).

TEX14_MOUSE
NC score	0.397184 (rank : 260)	θ value	3.77169e-06 (rank : 215)
Query Neighborhood Hits	471	Target Neighborhood Hits	1333	Shared Neighborhood Hits	264
SwissProt Accessions	Q7M6U3, Q3UT36, Q5NC10, Q5NC11, Q8CGK1, Q8CGK2, Q99MV8	Gene names	Tex14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TEX14_HUMAN
NC score	0.395228 (rank : 261)	θ value	4.1701e-05 (rank : 237)
Query Neighborhood Hits	471	Target Neighborhood Hits	1103	Shared Neighborhood Hits	246
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

DGKZ_HUMAN
NC score	0.394828 (rank : 262)	θ value	1.43324e-05 (rank : 223)
Query Neighborhood Hits	471	Target Neighborhood Hits	551	Shared Neighborhood Hits	219
SwissProt Accessions	Q13574, O00542	Gene names	DGKZ, DAGK6
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

DDEF2_HUMAN
NC score	0.388066 (rank : 263)	θ value	0.000121331 (rank : 247)
Query Neighborhood Hits	471	Target Neighborhood Hits	599	Shared Neighborhood Hits	235
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
NC score	0.385232 (rank : 264)	θ value	0.000121331 (rank : 248)
Query Neighborhood Hits	471	Target Neighborhood Hits	625	Shared Neighborhood Hits	237
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DGKZ_MOUSE
NC score	0.376584 (rank : 265)	θ value	8.40245e-06 (rank : 219)
Query Neighborhood Hits	471	Target Neighborhood Hits	542	Shared Neighborhood Hits	204
SwissProt Accessions	Q80UP3	Gene names	Dgkz
Domain Architecture
Description	Diacylglycerol kinase zeta (EC 2.7.1.107) (Diglyceride kinase zeta) (DGK-zeta) (DAG kinase zeta).

DDFL1_HUMAN
NC score	0.374760 (rank : 266)	θ value	0.00102713 (rank : 270)
Query Neighborhood Hits	471	Target Neighborhood Hits	353	Shared Neighborhood Hits	227
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

IKBL_HUMAN
NC score	0.368293 (rank : 267)	θ value	0.00175202 (rank : 276)
Query Neighborhood Hits	471	Target Neighborhood Hits	168	Shared Neighborhood Hits	140
SwissProt Accessions	Q9UBC1, Q14625, Q9UBX4	Gene names	NFKBIL1, IKBL
Domain Architecture
Description	NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like) (I- kappa-B-like) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1).

NOTC1_MOUSE
NC score	0.357688 (rank : 268)	θ value	5.62301e-10 (rank : 149)
Query Neighborhood Hits	471	Target Neighborhood Hits	916	Shared Neighborhood Hits	268
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

IKBL_MOUSE
NC score	0.357485 (rank : 269)	θ value	0.00390308 (rank : 290)
Query Neighborhood Hits	471	Target Neighborhood Hits	196	Shared Neighborhood Hits	139
SwissProt Accessions	O88995, Q91X16, Q9R1Y3	Gene names	Nfkbil1, Ikbl
Domain Architecture
Description	NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like) (I- kappa-B-like) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1).

DGKI_HUMAN
NC score	0.354364 (rank : 270)	θ value	0.000461057 (rank : 255)
Query Neighborhood Hits	471	Target Neighborhood Hits	609	Shared Neighborhood Hits	219
SwissProt Accessions	O75912, Q9NZ49	Gene names	DGKI
Domain Architecture
Description	Diacylglycerol kinase iota (EC 2.7.1.107) (Diglyceride kinase iota) (DGK-iota) (DAG kinase iota).

CENG2_HUMAN
NC score	0.341882 (rank : 271)	θ value	0.00390308 (rank : 289)
Query Neighborhood Hits	471	Target Neighborhood Hits	471	Shared Neighborhood Hits	254
SwissProt Accessions	Q9UPQ3, Q541S5, Q6P9D7, Q9NV93	Gene names	CENTG2, AGAP1, KIAA1099
Domain Architecture
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1) (GTP-binding and GTPase-activating protein 1) (GGAP1).

CENG1_MOUSE
NC score	0.341221 (rank : 272)	θ value	0.163984 (rank : 366)
Query Neighborhood Hits	471	Target Neighborhood Hits	531	Shared Neighborhood Hits	239
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

CENG2_MOUSE
NC score	0.339896 (rank : 273)	θ value	0.00134147 (rank : 272)
Query Neighborhood Hits	471	Target Neighborhood Hits	463	Shared Neighborhood Hits	251
SwissProt Accessions	Q8BXK8, Q3UHA0, Q6ZPX9, Q8BZG0	Gene names	Centg2, Agap1, Kiaa1099
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 2 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 1) (AGAP-1).

CENG1_HUMAN
NC score	0.338822 (rank : 274)	θ value	0.279714 (rank : 381)
Query Neighborhood Hits	471	Target Neighborhood Hits	544	Shared Neighborhood Hits	241
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

CLR59_HUMAN
NC score	0.319965 (rank : 275)	θ value	0.00102713 (rank : 269)
Query Neighborhood Hits	471	Target Neighborhood Hits	163	Shared Neighborhood Hits	142
SwissProt Accessions	Q96DZ5, Q8WWL1, Q96C99, Q9UFT7	Gene names	CLIPR59
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 170-related 59 kDa protein (CLIPR-59) (CLIP-170-related 59 kDa protein).

ANKZ1_MOUSE
NC score	0.309209 (rank : 276)	θ value	4.03905 (rank : 430)
Query Neighborhood Hits	471	Target Neighborhood Hits	208	Shared Neighborhood Hits	153
SwissProt Accessions	Q80UU1, Q9CZF5	Gene names	Ankzf1, D1Ertd161e
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1.

ABTB1_MOUSE
NC score	0.308264 (rank : 277)	θ value	0.0193708 (rank : 321)
Query Neighborhood Hits	471	Target Neighborhood Hits	349	Shared Neighborhood Hits	175
SwissProt Accessions	Q99LJ2, Q8C2K7, Q91XU4	Gene names	Abtb1, Bpoz
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 1.

ANKZ1_HUMAN
NC score	0.306257 (rank : 278)	θ value	1.81305 (rank : 410)
Query Neighborhood Hits	471	Target Neighborhood Hits	236	Shared Neighborhood Hits	162
SwissProt Accessions	Q9H8Y5, Q9NVZ4	Gene names	ANKZF1, ZNF744
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and zinc finger domain-containing protein 1 (Zinc finger protein 744).

DDEF1_MOUSE
NC score	0.297419 (rank : 279)	θ value	0.0431538 (rank : 340)
Query Neighborhood Hits	471	Target Neighborhood Hits	592	Shared Neighborhood Hits	196
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

CENG3_MOUSE
NC score	0.297284 (rank : 280)	θ value	8.99809 (rank : 456)
Query Neighborhood Hits	471	Target Neighborhood Hits	467	Shared Neighborhood Hits	229
SwissProt Accessions	Q8VHH5, Q812F7	Gene names	Centg3, Agap3
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

CENG3_HUMAN
NC score	0.296998 (rank : 281)	θ value	8.99809 (rank : 455)
Query Neighborhood Hits	471	Target Neighborhood Hits	455	Shared Neighborhood Hits	229
SwissProt Accessions	Q96P47, Q59EN0, Q96RK3	Gene names	CENTG3, AGAP3
Domain Architecture
Description	Centaurin-gamma 3 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 3) (AGAP-3) (MR1-interacting protein) (MRIP-1) (CRAM-associated GTPase) (CRAG).

ANKR9_MOUSE
NC score	0.272710 (rank : 282)	θ value	6.88961 (rank : 444)
Query Neighborhood Hits	471	Target Neighborhood Hits	120	Shared Neighborhood Hits	117
SwissProt Accessions	Q8BH83, Q3TA09, Q8BHR3	Gene names	Ankrd9
Domain Architecture
Description	Ankyrin repeat domain-containing protein 9.

TRPV3_MOUSE
NC score	0.270557 (rank : 283)	θ value	0.000786445 (rank : 263)
Query Neighborhood Hits	471	Target Neighborhood Hits	188	Shared Neighborhood Hits	136
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

ABTB1_HUMAN
NC score	0.266335 (rank : 284)	θ value	0.0563607 (rank : 351)
Query Neighborhood Hits	471	Target Neighborhood Hits	325	Shared Neighborhood Hits	160
SwissProt Accessions	Q969K4, Q6ZNU9, Q71MF1, Q96S62, Q96S63	Gene names	ABTB1, BPOZ
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and BTB/POZ domain-containing protein 1 (Elongation factor 1A-binding protein).

TRPV3_HUMAN
NC score	0.263071 (rank : 285)	θ value	0.0252991 (rank : 329)
Query Neighborhood Hits	471	Target Neighborhood Hits	198	Shared Neighborhood Hits	147
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

RSNL2_HUMAN
NC score	0.261413 (rank : 286)	θ value	0.00390308 (rank : 292)
Query Neighborhood Hits	471	Target Neighborhood Hits	136	Shared Neighborhood Hits	114
SwissProt Accessions	Q8N3C7, Q7Z4U3, Q96BR7, Q96MA5, Q9H7C0	Gene names	RSNL2
Domain Architecture	No domain graphic available
Description	Restin-like protein 2.

TRPV1_MOUSE
NC score	0.253751 (rank : 287)	θ value	0.62314 (rank : 399)
Query Neighborhood Hits	471	Target Neighborhood Hits	189	Shared Neighborhood Hits	160
SwissProt Accessions	Q704Y3, Q5SSE1, Q5SSE2, Q5SSE4, Q5WPV5, Q68SW0	Gene names	Trpv1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1).

BAT4_MOUSE
NC score	0.244496 (rank : 288)	θ value	θ > 10 (rank : 474)
Query Neighborhood Hits	471	Target Neighborhood Hits	171	Shared Neighborhood Hits	118
SwissProt Accessions	Q61858, Q9R065	Gene names	Bat4, Bat-4, G5
Domain Architecture
Description	Protein BAT4 (HLA-B-associated transcript 4) (G5 protein).

TRPV1_HUMAN
NC score	0.242328 (rank : 289)	θ value	0.62314 (rank : 398)
Query Neighborhood Hits	471	Target Neighborhood Hits	184	Shared Neighborhood Hits	152
SwissProt Accessions	Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22	Gene names	TRPV1, VR1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Capsaicin receptor).

TRPV2_HUMAN
NC score	0.227638 (rank : 290)	θ value	0.0961366 (rank : 361)
Query Neighborhood Hits	471	Target Neighborhood Hits	130	Shared Neighborhood Hits	115
SwissProt Accessions	Q9Y5S1, Q9Y670	Gene names	TRPV2, VRL
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1).

ANKR9_HUMAN
NC score	0.223489 (rank : 291)	θ value	8.99809 (rank : 453)
Query Neighborhood Hits	471	Target Neighborhood Hits	99	Shared Neighborhood Hits	98
SwissProt Accessions	Q96BM1	Gene names	ANKRD9
Domain Architecture
Description	Ankyrin repeat domain-containing protein 9.

RSNL2_MOUSE
NC score	0.220775 (rank : 292)	θ value	0.0252991 (rank : 325)
Query Neighborhood Hits	471	Target Neighborhood Hits	129	Shared Neighborhood Hits	96
SwissProt Accessions	Q8CI96, Q8BW09, Q921Q4, Q9D2S6	Gene names	Rsnl2
Domain Architecture	No domain graphic available
Description	Restin-like protein 2.

BAT4_HUMAN
NC score	0.219581 (rank : 293)	θ value	θ > 10 (rank : 473)
Query Neighborhood Hits	471	Target Neighborhood Hits	157	Shared Neighborhood Hits	108
SwissProt Accessions	O95872	Gene names	BAT4, G5
Domain Architecture
Description	Protein BAT4 (HLA-B-associated transcript 4) (G5 protein).

BIRC7_HUMAN
NC score	0.218830 (rank : 294)	θ value	2.21117e-06 (rank : 211)
Query Neighborhood Hits	471	Target Neighborhood Hits	185	Shared Neighborhood Hits	107
SwissProt Accessions	Q96CA5, Q9BQV0, Q9H2A8, Q9HAP7	Gene names	BIRC7, KIAP, LIVIN, MLIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 7 (Kidney inhibitor of apoptosis protein) (KIAP) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (Livin).

RNF34_MOUSE
NC score	0.213154 (rank : 295)	θ value	4.0297e-08 (rank : 180)
Query Neighborhood Hits	471	Target Neighborhood Hits	160	Shared Neighborhood Hits	77
SwissProt Accessions	Q99KR6, Q3UV45	Gene names	Rnf34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (Phafin-1).

RNF34_HUMAN
NC score	0.212775 (rank : 296)	θ value	5.26297e-08 (rank : 185)
Query Neighborhood Hits	471	Target Neighborhood Hits	153	Shared Neighborhood Hits	78
SwissProt Accessions	Q969K3, Q8NG47, Q9H6W8	Gene names	RNF34
Domain Architecture	No domain graphic available
Description	RING finger protein 34 (RING finger protein RIFF) (FYVE-RING finger protein Momo) (Human RING finger homologous to inhibitor of apoptosis protein) (hRFI) (Caspases-8 and -10-associated RING finger protein 1) (CARP-1) (Caspase regulator CARP1).

RFFL_MOUSE
NC score	0.198692 (rank : 297)	θ value	1.43324e-05 (rank : 225)
Query Neighborhood Hits	471	Target Neighborhood Hits	145	Shared Neighborhood Hits	74
SwissProt Accessions	Q6ZQM0, Q5SVC2, Q5SVC4, Q9D543, Q9D9B1	Gene names	Rffl
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (Fring).

RFFL_HUMAN
NC score	0.196824 (rank : 298)	θ value	1.43324e-05 (rank : 224)
Query Neighborhood Hits	471	Target Neighborhood Hits	175	Shared Neighborhood Hits	76
SwissProt Accessions	Q8WZ73, Q8NHW0, Q8TBY7, Q96BE6	Gene names	RFFL, RNF189, RNF34L
Domain Architecture	No domain graphic available
Description	Rififylin (RING finger and FYVE-like domain-containing protein 1) (FYVE-RING finger protein Sakura) (Fring) (Caspases-8 and -10- associated RING finger protein 2) (CARP-2) (Caspase regulator CARP2) (RING finger protein 189) (RING finger protein 34-like).

BIRC8_HUMAN
NC score	0.187428 (rank : 299)	θ value	6.43352e-06 (rank : 218)
Query Neighborhood Hits	471	Target Neighborhood Hits	121	Shared Neighborhood Hits	73
SwissProt Accessions	Q96P09, Q96RW5	Gene names	BIRC8, ILP2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 8 (Inhibitor of apoptosis- like protein 2) (IAP-like protein 2) (ILP-2) (Testis-specific inhibitor of apoptosis).

BIRC3_HUMAN
NC score	0.177827 (rank : 300)	θ value	2.61198e-07 (rank : 197)
Query Neighborhood Hits	471	Target Neighborhood Hits	133	Shared Neighborhood Hits	86
SwissProt Accessions	Q13489, Q16628, Q9HC27, Q9UP46	Gene names	BIRC3, API2, IAP1, MIHC
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (HIAP1) (HIAP-1) (C-IAP2) (TNFR2-TRAF signaling complex protein 1) (IAP homolog C) (Apoptosis inhibitor 2) (API2).

BIRC2_HUMAN
NC score	0.175636 (rank : 301)	θ value	8.97725e-08 (rank : 188)
Query Neighborhood Hits	471	Target Neighborhood Hits	142	Shared Neighborhood Hits	89
SwissProt Accessions	Q13490, Q16516, Q4TTG0	Gene names	BIRC2, API1, IAP2, MIHB
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (HIAP2) (HIAP-2) (C-IAP1) (TNFR2-TRAF signaling complex protein 2) (IAP homolog B).

BIRC3_MOUSE
NC score	0.175492 (rank : 302)	θ value	7.59969e-07 (rank : 203)
Query Neighborhood Hits	471	Target Neighborhood Hits	113	Shared Neighborhood Hits	77
SwissProt Accessions	O08863	Gene names	Birc3, Birc2, Iap1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 3 (Inhibitor of apoptosis protein 1) (MIAP1) (MIAP-1).

TRPV2_MOUSE
NC score	0.175216 (rank : 303)	θ value	6.88961 (rank : 450)
Query Neighborhood Hits	471	Target Neighborhood Hits	111	Shared Neighborhood Hits	97
SwissProt Accessions	Q9WTR1, Q99K71	Gene names	Trpv2, Grc
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Growth factor-regulated calcium channel) (GRC).

CMTA1_HUMAN
NC score	0.174279 (rank : 304)	θ value	θ > 10 (rank : 478)
Query Neighborhood Hits	471	Target Neighborhood Hits	217	Shared Neighborhood Hits	100
SwissProt Accessions	Q9Y6Y1, Q5VUE1	Gene names	CAMTA1, KIAA0833
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 1.

RNF26_HUMAN
NC score	0.173986 (rank : 305)	θ value	0.00175202 (rank : 277)
Query Neighborhood Hits	471	Target Neighborhood Hits	95	Shared Neighborhood Hits	66
SwissProt Accessions	Q9BY78	Gene names	RNF26
Domain Architecture	No domain graphic available
Description	RING finger protein 26.

BIRC2_MOUSE
NC score	0.173814 (rank : 306)	θ value	5.81887e-07 (rank : 201)
Query Neighborhood Hits	471	Target Neighborhood Hits	137	Shared Neighborhood Hits	84
SwissProt Accessions	Q62210, O08864	Gene names	Birc2, Birc3, Iap2
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 2 (Inhibitor of apoptosis protein 2) (MIAP2) (MIAP-2).

BIRC4_MOUSE
NC score	0.163833 (rank : 307)	θ value	1.29631e-06 (rank : 207)
Query Neighborhood Hits	471	Target Neighborhood Hits	89	Shared Neighborhood Hits	64
SwissProt Accessions	Q60989, O08865	Gene names	Birc4, Aipa, Api3, Miha, Xiap
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP homolog A) (MIAP3) (MIAP-3).

BIRC4_HUMAN
NC score	0.163747 (rank : 308)	θ value	1.69304e-06 (rank : 209)
Query Neighborhood Hits	471	Target Neighborhood Hits	89	Shared Neighborhood Hits	64
SwissProt Accessions	P98170, Q9NQ14	Gene names	BIRC4, API3, IAP3, XIAP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 4 (Inhibitor of apoptosis protein 3) (X-linked inhibitor of apoptosis protein) (X-linked IAP) (IAP-like protein) (HILP).

CGRF1_MOUSE
NC score	0.154439 (rank : 309)	θ value	0.000602161 (rank : 259)
Query Neighborhood Hits	471	Target Neighborhood Hits	47	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BMJ7, Q3U3F1, Q8CI24	Gene names	Cgrrf1, Cgr19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

SQSTM_MOUSE
NC score	0.150746 (rank : 310)	θ value	1.87187e-05 (rank : 228)
Query Neighborhood Hits	471	Target Neighborhood Hits	82	Shared Neighborhood Hits	22
SwissProt Accessions	Q64337, Q99JM8	Gene names	Sqstm1, A170, STAP
Domain Architecture	No domain graphic available
Description	Sequestosome-1 (Ubiquitin-binding protein p62) (STONE14).

CGRF1_HUMAN
NC score	0.150537 (rank : 311)	θ value	0.00102713 (rank : 267)
Query Neighborhood Hits	471	Target Neighborhood Hits	51	Shared Neighborhood Hits	38
SwissProt Accessions	Q99675, Q96BX2	Gene names	CGRRF1, CGR19
Domain Architecture	No domain graphic available
Description	Cell growth regulator with RING finger domain 1 (Cell growth regulatory gene 19 protein).

SQSTM_HUMAN
NC score	0.147566 (rank : 312)	θ value	2.44474e-05 (rank : 233)
Query Neighborhood Hits	471	Target Neighborhood Hits	61	Shared Neighborhood Hits	19
SwissProt Accessions	Q13501, Q13446, Q9BUV7, Q9BVS6, Q9UEU1	Gene names	SQSTM1, ORCA
Domain Architecture	No domain graphic available
Description	Sequestosome-1 (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (EBI3-associated protein of 60 kDa) (p60) (EBIAP).

NEURL_MOUSE
NC score	0.139609 (rank : 313)	θ value	0.00665767 (rank : 301)
Query Neighborhood Hits	471	Target Neighborhood Hits	106	Shared Neighborhood Hits	66
SwissProt Accessions	Q923S6, Q91ZT6, Q9CWF1, Q9QWF1	Gene names	Neurl, Neurl1
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (m-neuralized 1) (m-neu1).

TRPV4_HUMAN
NC score	0.139145 (rank : 314)	θ value	4.03905 (rank : 438)
Query Neighborhood Hits	471	Target Neighborhood Hits	150	Shared Neighborhood Hits	86
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

CU081_HUMAN
NC score	0.138455 (rank : 315)	θ value	θ > 10 (rank : 481)
Query Neighborhood Hits	471	Target Neighborhood Hits	9	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NFU9	Gene names	C21orf81
Domain Architecture	No domain graphic available
Description	Protein C21orf81.

NEUL1_HUMAN
NC score	0.138384 (rank : 316)	θ value	0.00869519 (rank : 306)
Query Neighborhood Hits	471	Target Neighborhood Hits	114	Shared Neighborhood Hits	67
SwissProt Accessions	O76050, Q5TDR2, Q5TDR3, Q8TAN0, Q9H463	Gene names	NEURL, NEURL1, RNF67
Domain Architecture	No domain graphic available
Description	Neuralized-like protein 1 (h-neuralized 1) (h-neu) (RING finger protein 67).

ANKF1_HUMAN
NC score	0.136579 (rank : 317)	θ value	θ > 10 (rank : 472)
Query Neighborhood Hits	471	Target Neighborhood Hits	126	Shared Neighborhood Hits	68
SwissProt Accessions	Q8N957	Gene names	ANKFN1
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and fibronectin type-III domain-containing protein 1.

CMTA2_HUMAN
NC score	0.134539 (rank : 318)	θ value	θ > 10 (rank : 479)
Query Neighborhood Hits	471	Target Neighborhood Hits	199	Shared Neighborhood Hits	87
SwissProt Accessions	O94983, Q7Z6M8, Q8N3V0, Q8NDG4, Q96G17	Gene names	CAMTA2, KIAA0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

TRPV4_MOUSE
NC score	0.127214 (rank : 319)	θ value	8.99809 (rank : 471)
Query Neighborhood Hits	471	Target Neighborhood Hits	117	Shared Neighborhood Hits	83
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

RNF8_MOUSE
NC score	0.127105 (rank : 320)	θ value	1.87187e-05 (rank : 227)
Query Neighborhood Hits	471	Target Neighborhood Hits	618	Shared Neighborhood Hits	128
SwissProt Accessions	Q8VC56, Q9JK13	Gene names	Rnf8
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8) (AIP37) (ActA-interacting protein 37) (LaXp180).

RKHD1_HUMAN
NC score	0.126860 (rank : 321)	θ value	0.21417 (rank : 375)
Query Neighborhood Hits	471	Target Neighborhood Hits	163	Shared Neighborhood Hits	59
SwissProt Accessions	Q86XN8	Gene names	RKHD1, KIAA2031
Domain Architecture
Description	RING finger and KH domain-containing protein 1.

MGRN1_MOUSE
NC score	0.124384 (rank : 322)	θ value	0.0113563 (rank : 313)
Query Neighborhood Hits	471	Target Neighborhood Hits	149	Shared Neighborhood Hits	78
SwissProt Accessions	Q9D074, Q3U5V9, Q3UDA1, Q6ZQ97, Q8BZM9	Gene names	Mgrn1, Kiaa0544
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1).

CMTA2_MOUSE
NC score	0.122760 (rank : 323)	θ value	θ > 10 (rank : 480)
Query Neighborhood Hits	471	Target Neighborhood Hits	216	Shared Neighborhood Hits	77
SwissProt Accessions	Q80Y50, Q3TFK0, Q5SX68, Q80TP1, Q8R0D9, Q8R2N5	Gene names	Camta2, Kiaa0909
Domain Architecture	No domain graphic available
Description	Calmodulin-binding transcription activator 2.

RN141_HUMAN
NC score	0.121742 (rank : 324)	θ value	0.00298849 (rank : 286)
Query Neighborhood Hits	471	Target Neighborhood Hits	199	Shared Neighborhood Hits	88
SwissProt Accessions	Q8WVD5, Q9NZB4	Gene names	RNF141, ZNF230
Domain Architecture	No domain graphic available
Description	RING finger protein 141 (Zinc finger protein 230).

ZSWM2_HUMAN
NC score	0.121400 (rank : 325)	θ value	0.000121331 (rank : 250)
Query Neighborhood Hits	471	Target Neighborhood Hits	151	Shared Neighborhood Hits	49
SwissProt Accessions	Q8NEG5	Gene names	ZSWIM2
Domain Architecture
Description	Zinc finger SWIM domain-containing protein 2.

RN141_MOUSE
NC score	0.120448 (rank : 326)	θ value	0.00390308 (rank : 291)
Query Neighborhood Hits	471	Target Neighborhood Hits	200	Shared Neighborhood Hits	87
SwissProt Accessions	Q99MB7, Q9D040, Q9D5C4, Q9D9L0	Gene names	Rnf141, Znf230
Domain Architecture	No domain graphic available
Description	RING finger protein 141 (Zinc finger protein 230).

MGRN1_HUMAN
NC score	0.120346 (rank : 327)	θ value	0.0113563 (rank : 312)
Query Neighborhood Hits	471	Target Neighborhood Hits	192	Shared Neighborhood Hits	77
SwissProt Accessions	O60291, Q86W76	Gene names	MGRN1, KIAA0544, RNF156
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase MGRN1 (EC 6.3.2.-) (Mahogunin ring finger protein 1) (RING finger protein 156).

TRI26_MOUSE
NC score	0.117302 (rank : 328)	θ value	0.0252991 (rank : 328)
Query Neighborhood Hits	471	Target Neighborhood Hits	339	Shared Neighborhood Hits	123
SwissProt Accessions	Q99PN3, Q8C9E9, Q8JZT7, Q99PN2	Gene names	Trim26, Znf173
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173).

TRI31_HUMAN
NC score	0.115926 (rank : 329)	θ value	0.00175202 (rank : 278)
Query Neighborhood Hits	471	Target Neighborhood Hits	299	Shared Neighborhood Hits	107
SwissProt Accessions	Q9BZY9, Q53H52, Q5RI37, Q5SRJ7, Q5SRJ8, Q5SS28, Q96AK4, Q96AP8, Q99579, Q9BZY8	Gene names	TRIM31, C6orf13, RNF
Domain Architecture
Description	Tripartite motif-containing protein 31.

TRI26_HUMAN
NC score	0.115151 (rank : 330)	θ value	0.0330416 (rank : 337)
Query Neighborhood Hits	471	Target Neighborhood Hits	335	Shared Neighborhood Hits	120
SwissProt Accessions	Q12899	Gene names	TRIM26, RNF95, ZNF173
Domain Architecture
Description	Tripartite motif-containing protein 26 (Zinc finger protein 173) (Acid finger protein) (AFP) (RING finger protein 95).

LRSM1_MOUSE
NC score	0.113651 (rank : 331)	θ value	2.88788e-06 (rank : 213)
Query Neighborhood Hits	471	Target Neighborhood Hits	874	Shared Neighborhood Hits	94
SwissProt Accessions	Q80ZI6	Gene names	Lrsam1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase).

TRI73_HUMAN
NC score	0.112155 (rank : 332)	θ value	0.0330416 (rank : 338)
Query Neighborhood Hits	471	Target Neighborhood Hits	258	Shared Neighborhood Hits	102
SwissProt Accessions	Q86UV7, Q8N0S3	Gene names	TRIM73, TRIM50B
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 73 (Tripartite motif-containing protein 50B).

TOPRS_MOUSE
NC score	0.110950 (rank : 333)	θ value	0.000158464 (rank : 253)
Query Neighborhood Hits	471	Target Neighborhood Hits	263	Shared Neighborhood Hits	84
SwissProt Accessions	Q80Z37, Q3U5B5, Q3UPZ1, Q3USN3, Q3UZ55, Q8BXP2, Q8CFF5, Q8CGC8, Q920L3	Gene names	Topors
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

RNF8_HUMAN
NC score	0.110828 (rank : 334)	θ value	0.0148317 (rank : 316)
Query Neighborhood Hits	471	Target Neighborhood Hits	622	Shared Neighborhood Hits	129
SwissProt Accessions	O76064	Gene names	RNF8, KIAA0646
Domain Architecture
Description	Ubiquitin ligase protein RNF8 (EC 6.3.2.-) (RING finger protein 8).

TOPRS_HUMAN
NC score	0.110270 (rank : 335)	θ value	0.000158464 (rank : 252)
Query Neighborhood Hits	471	Target Neighborhood Hits	286	Shared Neighborhood Hits	88
SwissProt Accessions	Q9NS56, O43273, Q6P987, Q9NS55, Q9UNR9	Gene names	TOPORS, LUN, TP53BPL
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein E3 ligase Topors (EC 6.3.2.-) (SUMO1-protein E3 ligase Topors) (Topoisomerase I-binding RING finger protein) (Topoisomerase I-binding arginine/serine-rich protein) (Tumor suppressor p53-binding protein 3) (p53-binding protein 3) (p53BP3).

LRSM1_HUMAN
NC score	0.109518 (rank : 336)	θ value	4.92598e-06 (rank : 217)
Query Neighborhood Hits	471	Target Neighborhood Hits	1078	Shared Neighborhood Hits	100
SwissProt Accessions	Q6UWE0, Q5VVV0, Q8NB40, Q96GT5, Q96MX5, Q96MZ7	Gene names	LRSAM1, TAL
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein LRSAM1 (EC 6.3.2.-) (Leucine-rich repeat and sterile alpha motif-containing protein 1) (Tsg101-associated ligase) (hTAL).

MYLIP_HUMAN
NC score	0.107450 (rank : 337)	θ value	2.44474e-05 (rank : 232)
Query Neighborhood Hits	471	Target Neighborhood Hits	162	Shared Neighborhood Hits	73
SwissProt Accessions	Q8WY64, Q9BU73, Q9NRL9, Q9UHE7	Gene names	MYLIP, BZF1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

TRI50_MOUSE
NC score	0.107292 (rank : 338)	θ value	0.000121331 (rank : 249)
Query Neighborhood Hits	471	Target Neighborhood Hits	326	Shared Neighborhood Hits	116
SwissProt Accessions	Q810I2	Gene names	Trim50
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 50.

RO52_HUMAN
NC score	0.106479 (rank : 339)	θ value	0.0193708 (rank : 323)
Query Neighborhood Hits	471	Target Neighborhood Hits	419	Shared Neighborhood Hits	124
SwissProt Accessions	P19474, Q96RF8	Gene names	TRIM21, RNF81, RO52, SSA1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21) (RING finger protein 81).

TRI74_HUMAN
NC score	0.106205 (rank : 340)	θ value	0.0736092 (rank : 356)
Query Neighborhood Hits	471	Target Neighborhood Hits	249	Shared Neighborhood Hits	97
SwissProt Accessions	Q86UV6	Gene names	TRIM74, TRIM50C
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 74 (Tripartite motif-containing protein 50C).

TRI12_MOUSE
NC score	0.105493 (rank : 341)	θ value	0.0431538 (rank : 349)
Query Neighborhood Hits	471	Target Neighborhood Hits	387	Shared Neighborhood Hits	107
SwissProt Accessions	Q99PQ1, Q9D704	Gene names	Trim12
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 12.

CHFR_HUMAN
NC score	0.105376 (rank : 342)	θ value	0.0113563 (rank : 308)
Query Neighborhood Hits	471	Target Neighborhood Hits	255	Shared Neighborhood Hits	94
SwissProt Accessions	Q96EP1, Q96SL3, Q9NRT4, Q9NT32, Q9NVD5	Gene names	CHFR
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

ZSWM2_MOUSE
NC score	0.104663 (rank : 343)	θ value	0.000602161 (rank : 260)
Query Neighborhood Hits	471	Target Neighborhood Hits	132	Shared Neighborhood Hits	43
SwissProt Accessions	Q9D9X6	Gene names	Zswim2
Domain Architecture
Description	Zinc finger SWIM domain-containing protein 2.

TRPC6_HUMAN
NC score	0.104263 (rank : 344)	θ value	4.03905 (rank : 436)
Query Neighborhood Hits	471	Target Neighborhood Hits	171	Shared Neighborhood Hits	108
SwissProt Accessions	Q9Y210, Q9HCW3, Q9NQA8, Q9NQA9	Gene names	TRPC6, TRP6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6).

BRCA1_HUMAN
NC score	0.103366 (rank : 345)	θ value	0.0330416 (rank : 331)
Query Neighborhood Hits	471	Target Neighborhood Hits	381	Shared Neighborhood Hits	103
SwissProt Accessions	P38398	Gene names	BRCA1, RNF53
Domain Architecture
Description	Breast cancer type 1 susceptibility protein (RING finger protein 53).

BRCA1_MOUSE
NC score	0.103168 (rank : 346)	θ value	0.00869519 (rank : 303)
Query Neighborhood Hits	471	Target Neighborhood Hits	436	Shared Neighborhood Hits	105
SwissProt Accessions	P48754, Q60957, Q60983	Gene names	Brca1
Domain Architecture
Description	Breast cancer type 1 susceptibility protein homolog.

HERC2_MOUSE
NC score	0.102397 (rank : 347)	θ value	3.29651e-10 (rank : 145)
Query Neighborhood Hits	471	Target Neighborhood Hits	167	Shared Neighborhood Hits	28
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_HUMAN
NC score	0.102342 (rank : 348)	θ value	1.9326e-10 (rank : 142)
Query Neighborhood Hits	471	Target Neighborhood Hits	163	Shared Neighborhood Hits	26
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

TRI50_HUMAN
NC score	0.102260 (rank : 349)	θ value	0.00228821 (rank : 283)
Query Neighborhood Hits	471	Target Neighborhood Hits	294	Shared Neighborhood Hits	108
SwissProt Accessions	Q86XT4, Q86XT3	Gene names	TRIM50, TRIM50A
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 50.

RING1_MOUSE
NC score	0.099649 (rank : 350)	θ value	0.0431538 (rank : 347)
Query Neighborhood Hits	471	Target Neighborhood Hits	220	Shared Neighborhood Hits	91
SwissProt Accessions	O35730, Q3U242, Q3U333, Q4FK33, Q63ZX8, Q921Z8	Gene names	Ring1, Ring1A, Rnf1
Domain Architecture	No domain graphic available
Description	Polycomb complex protein RING1 (RING finger protein 1) (Transcription repressor Ring1A).

RING1_HUMAN
NC score	0.098658 (rank : 351)	θ value	0.0431538 (rank : 346)
Query Neighborhood Hits	471	Target Neighborhood Hits	219	Shared Neighborhood Hits	89
SwissProt Accessions	Q06587, Q5JP96, Q5SQW2, Q86V19	Gene names	RING1, RNF1
Domain Architecture
Description	Polycomb complex protein RING1 (RING finger protein 1).

TRIM5_HUMAN
NC score	0.097565 (rank : 352)	θ value	0.00298849 (rank : 287)
Query Neighborhood Hits	471	Target Neighborhood Hits	424	Shared Neighborhood Hits	105
SwissProt Accessions	Q9C035, Q8WU46, Q96SR5, Q9C031, Q9C032, Q9C033, Q9C034	Gene names	TRIM5, RNF88
Domain Architecture
Description	Tripartite motif-containing protein 5 (EC 6.3.2.-) (RING finger protein 88).

TRI30_MOUSE
NC score	0.096937 (rank : 353)	θ value	0.00869519 (rank : 307)
Query Neighborhood Hits	471	Target Neighborhood Hits	434	Shared Neighborhood Hits	100
SwissProt Accessions	P15533, Q99K55, Q99PQ7, Q99PQ8, Q99PQ9	Gene names	Trim30, Rpt-1, Rpt1
Domain Architecture
Description	Tripartite motif-containing protein 30 (Down regulatory protein of interleukin 2 receptor).

TRIM6_MOUSE
NC score	0.095673 (rank : 354)	θ value	0.00134147 (rank : 274)
Query Neighborhood Hits	471	Target Neighborhood Hits	451	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BGE7, Q99PQ6	Gene names	Trim6
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 6.

TRI34_HUMAN
NC score	0.095213 (rank : 355)	θ value	0.0961366 (rank : 360)
Query Neighborhood Hits	471	Target Neighborhood Hits	416	Shared Neighborhood Hits	98
SwissProt Accessions	Q9BYJ4, Q9C016, Q9HCR0, Q9HCR1, Q9HCR2	Gene names	TRIM34, IFP1, RNF21
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 34 (Interferon-responsive finger protein 1) (RING finger protein 21).

TRI60_HUMAN
NC score	0.094661 (rank : 356)	θ value	0.00509761 (rank : 295)
Query Neighborhood Hits	471	Target Neighborhood Hits	357	Shared Neighborhood Hits	117
SwissProt Accessions	Q495X7, Q8NA35	Gene names	TRIM60, RNF129
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 60 (RING finger protein 129).

SIAH2_MOUSE
NC score	0.094105 (rank : 357)	θ value	0.0252991 (rank : 327)
Query Neighborhood Hits	471	Target Neighborhood Hits	101	Shared Neighborhood Hits	45
SwissProt Accessions	Q06986	Gene names	Siah2
Domain Architecture
Description	Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (mSiah2).

TRIM4_HUMAN
NC score	0.093942 (rank : 358)	θ value	0.0148317 (rank : 318)
Query Neighborhood Hits	471	Target Neighborhood Hits	321	Shared Neighborhood Hits	103
SwissProt Accessions	Q9C037, Q96F06, Q9C036	Gene names	TRIM4, RNF87
Domain Architecture
Description	Tripartite motif-containing protein 4 (RING finger protein 87).

LRRK1_MOUSE
NC score	0.093828 (rank : 359)	θ value	0.00228821 (rank : 282)
Query Neighborhood Hits	471	Target Neighborhood Hits	1267	Shared Neighborhood Hits	124
SwissProt Accessions	Q3UHC2, Q3U476, Q66JQ4, Q6GQR9, Q6NZF5, Q6ZPI4, Q8BKP3, Q8BU93, Q8BUY0, Q8BVV2, Q8R085	Gene names	Lrrk1, Kiaa1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

TRI35_HUMAN
NC score	0.093734 (rank : 360)	θ value	0.0431538 (rank : 350)
Query Neighborhood Hits	471	Target Neighborhood Hits	382	Shared Neighborhood Hits	113
SwissProt Accessions	Q9UPQ4, Q86XQ0, Q8WVA4	Gene names	TRIM35, HLS5, KIAA1098
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 35 (Hemopoietic lineage switch protein 5).

TRI22_HUMAN
NC score	0.093654 (rank : 361)	θ value	0.0330416 (rank : 336)
Query Neighborhood Hits	471	Target Neighborhood Hits	396	Shared Neighborhood Hits	95
SwissProt Accessions	Q8IYM9, Q15521	Gene names	TRIM22, RNF94, STAF50
Domain Architecture
Description	Tripartite motif-containing protein 22 (RING finger protein 94) (50 kDa-stimulated trans-acting factor) (Staf-50).

MYLIP_MOUSE
NC score	0.093618 (rank : 362)	θ value	5.44631e-05 (rank : 242)
Query Neighborhood Hits	471	Target Neighborhood Hits	139	Shared Neighborhood Hits	56
SwissProt Accessions	Q8BM54, Q3TX01, Q8BLY9, Q91Z47	Gene names	Mylip
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase MYLIP (EC 6.3.2.-) (Myosin regulatory light chain- interacting protein) (MIR).

RING2_MOUSE
NC score	0.093518 (rank : 363)	θ value	0.0563607 (rank : 353)
Query Neighborhood Hits	471	Target Neighborhood Hits	199	Shared Neighborhood Hits	85
SwissProt Accessions	Q9CQJ4, O35699, O35729, Q4FJV5, Q8C1X8	Gene names	Rnf2, DinG, Ring1b
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein RING2 (EC 6.3.2.-) (RING finger protein 2) (RING finger protein 1B) (RING1b).

RING2_HUMAN
NC score	0.093501 (rank : 364)	θ value	0.0563607 (rank : 352)
Query Neighborhood Hits	471	Target Neighborhood Hits	201	Shared Neighborhood Hits	85
SwissProt Accessions	Q99496, Q5TEN1, Q5TEN2	Gene names	RNF2, BAP1, DING, HIPI3, RING1B
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase protein RING2 (EC 6.3.2.-) (RING finger protein 2) (RING finger protein 1B) (RING1b) (RING finger protein BAP-1) (DinG protein) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3).

TRIM6_HUMAN
NC score	0.093459 (rank : 365)	θ value	0.00665767 (rank : 302)
Query Neighborhood Hits	471	Target Neighborhood Hits	412	Shared Neighborhood Hits	102
SwissProt Accessions	Q9C030, Q86WZ8, Q9HCR1	Gene names	TRIM6, RNF89
Domain Architecture
Description	Tripartite motif-containing protein 6 (RING finger protein 89).

SIAH2_HUMAN
NC score	0.093324 (rank : 366)	θ value	0.0252991 (rank : 326)
Query Neighborhood Hits	471	Target Neighborhood Hits	94	Shared Neighborhood Hits	45
SwissProt Accessions	O43255, O43270	Gene names	SIAH2
Domain Architecture
Description	Ubiquitin ligase SIAH2 (EC 6.3.2.-) (Seven in absentia homolog 2) (Siah-2) (hSiah2).

PEX10_HUMAN
NC score	0.092672 (rank : 367)	θ value	5.27518 (rank : 440)
Query Neighborhood Hits	471	Target Neighborhood Hits	255	Shared Neighborhood Hits	105
SwissProt Accessions	O60683, Q5T095, Q9BW90	Gene names	PEX10, RNF69
Domain Architecture
Description	Peroxisome assembly protein 10 (Peroxin-10) (Peroxisome biogenesis factor 10) (RING finger protein 69).

RN185_MOUSE
NC score	0.092667 (rank : 368)	θ value	0.21417 (rank : 376)
Query Neighborhood Hits	471	Target Neighborhood Hits	211	Shared Neighborhood Hits	93
SwissProt Accessions	Q91YT2, Q6ZWS3	Gene names	Rnf185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

CHFR_MOUSE
NC score	0.092534 (rank : 369)	θ value	0.47712 (rank : 389)
Query Neighborhood Hits	471	Target Neighborhood Hits	264	Shared Neighborhood Hits	97
SwissProt Accessions	Q810L3, Q8BJZ9, Q8BWH4	Gene names	Chfr
Domain Architecture
Description	Ubiquitin-protein ligase CHFR (EC 6.3.2.-) (Checkpoint with forkhead and RING finger domains protein).

TRI52_HUMAN
NC score	0.092490 (rank : 370)	θ value	0.47712 (rank : 390)
Query Neighborhood Hits	471	Target Neighborhood Hits	213	Shared Neighborhood Hits	87
SwissProt Accessions	Q96A61	Gene names	TRIM52, RNF102
Domain Architecture
Description	Tripartite motif-containing protein 52 (RING finger protein 102).

TRI39_MOUSE
NC score	0.092118 (rank : 371)	θ value	0.00175202 (rank : 280)
Query Neighborhood Hits	471	Target Neighborhood Hits	691	Shared Neighborhood Hits	117
SwissProt Accessions	Q9ESN2, Q8BPR5, Q8K0F7	Gene names	Trim39, Rnf23, Tfp
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

RN185_HUMAN
NC score	0.091504 (rank : 372)	θ value	0.365318 (rank : 387)
Query Neighborhood Hits	471	Target Neighborhood Hits	213	Shared Neighborhood Hits	93
SwissProt Accessions	Q96GF1, Q8N900	Gene names	RNF185
Domain Architecture	No domain graphic available
Description	RING finger protein 185.

RO52_MOUSE
NC score	0.091407 (rank : 373)	θ value	θ > 10 (rank : 500)
Query Neighborhood Hits	471	Target Neighborhood Hits	360	Shared Neighborhood Hits	116
SwissProt Accessions	Q62191	Gene names	Trim21, Ro52, Ssa1
Domain Architecture
Description	52 kDa Ro protein (Sjoegren syndrome type A antigen) (SS-A) (Ro(SS-A)) (52 kDa ribonucleoprotein autoantigen Ro/SS-A) (Tripartite motif- containing protein 21).

TRI34_MOUSE
NC score	0.090803 (rank : 374)	θ value	0.0148317 (rank : 317)
Query Neighborhood Hits	471	Target Neighborhood Hits	332	Shared Neighborhood Hits	92
SwissProt Accessions	Q99PP6, Q99PP4, Q99PP5	Gene names	Trim34
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 34.

TRI39_HUMAN
NC score	0.090235 (rank : 375)	θ value	0.00175202 (rank : 279)
Query Neighborhood Hits	471	Target Neighborhood Hits	693	Shared Neighborhood Hits	120
SwissProt Accessions	Q9HCM9, Q76BL3, Q8IYT9, Q96IB6	Gene names	TRIM39, RNF23, TFP
Domain Architecture
Description	Tripartite motif-containing protein 39 (RING finger protein 23) (Testis-abundant finger protein).

TRI35_MOUSE
NC score	0.090003 (rank : 376)	θ value	0.125558 (rank : 363)
Query Neighborhood Hits	471	Target Neighborhood Hits	465	Shared Neighborhood Hits	109
SwissProt Accessions	Q8C006, Q6ZPY0, Q7TQL7, Q810V7, Q8BVY9, Q8VID4, Q9CW74, Q9D208	Gene names	Trim35, Hls5, Kiaa1098, Mair
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 35 (Macrophage-derived apoptosis- inducing RBCC protein) (Protein MAIR) (Protein Nc8) (Hemopoietic lineage switch protein 5).

DTNA_MOUSE
NC score	0.089695 (rank : 377)	θ value	0.00509761 (rank : 294)
Query Neighborhood Hits	471	Target Neighborhood Hits	264	Shared Neighborhood Hits	28
SwissProt Accessions	Q9D2N4, P97319, Q61498, Q61499, Q9QZZ5, Q9WUL9, Q9WUM0	Gene names	Dtna, Dtn
Domain Architecture
Description	Dystrobrevin alpha (Alpha-dystrobrevin).

DTNA_HUMAN
NC score	0.087762 (rank : 378)	θ value	0.0113563 (rank : 310)
Query Neighborhood Hits	471	Target Neighborhood Hits	295	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y4J8, O15332, O15333, O75697, Q13197, Q13198, Q13199, Q13498, Q13499, Q13500	Gene names	DTNA, DRP3
Domain Architecture
Description	Dystrobrevin alpha (Dystrobrevin-alpha) (Dystrophin-related protein 3).

SIA1B_MOUSE
NC score	0.087459 (rank : 379)	θ value	0.21417 (rank : 378)
Query Neighborhood Hits	471	Target Neighborhood Hits	69	Shared Neighborhood Hits	41
SwissProt Accessions	Q06985, Q7TPV6	Gene names	Siah1b
Domain Architecture
Description	Ubiquitin ligase SIAH1B (EC 6.3.2.-) (Seven in absentia homolog 1b) (Siah1b) (Siah-1b).

SIA1A_MOUSE
NC score	0.086328 (rank : 380)	θ value	0.21417 (rank : 377)
Query Neighborhood Hits	471	Target Neighborhood Hits	72	Shared Neighborhood Hits	41
SwissProt Accessions	P61092, Q06984	Gene names	Siah1a
Domain Architecture
Description	Ubiquitin ligase SIAH1A (EC 6.3.2.-) (Seven in absentia homolog 1a) (Siah1a) (Siah-1a) (mSiah-1a).

SIAH1_HUMAN
NC score	0.086303 (rank : 381)	θ value	0.21417 (rank : 379)
Query Neighborhood Hits	471	Target Neighborhood Hits	72	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IUQ4, O43269, Q92880	Gene names	SIAH1, HUMSIAH
Domain Architecture
Description	Ubiquitin ligase SIAH1 (EC 6.3.2.-) (Seven in absentia homolog 1) (Siah-1) (Siah-1a).

TRI40_HUMAN
NC score	0.086269 (rank : 382)	θ value	θ > 10 (rank : 515)
Query Neighborhood Hits	471	Target Neighborhood Hits	279	Shared Neighborhood Hits	96
SwissProt Accessions	Q6P9F5, Q8TD96	Gene names	TRIM40, RNF35
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 40 (RING finger protein 35).

DTNB_HUMAN
NC score	0.086018 (rank : 383)	θ value	0.0113563 (rank : 311)
Query Neighborhood Hits	471	Target Neighborhood Hits	255	Shared Neighborhood Hits	24
SwissProt Accessions	O60941, O43782, O60881, O75538, Q9UE14, Q9UE15, Q9UE16	Gene names	DTNB
Domain Architecture
Description	Dystrobrevin beta (Beta-dystrobrevin) (DTN-B).

TRI68_HUMAN
NC score	0.085632 (rank : 384)	θ value	0.163984 (rank : 370)
Query Neighborhood Hits	471	Target Neighborhood Hits	267	Shared Neighborhood Hits	94
SwissProt Accessions	Q6AZZ1, Q8WZ70, Q96PF7, Q9H9C2, Q9NW18	Gene names	TRIM68, RNF137, SS56
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 68 (RING finger protein 137) (SSA protein SS-56) (SS-56).

DTNB_MOUSE
NC score	0.085489 (rank : 385)	θ value	0.0431538 (rank : 343)
Query Neighborhood Hits	471	Target Neighborhood Hits	263	Shared Neighborhood Hits	25
SwissProt Accessions	O70585, O70563, Q9CTZ1	Gene names	Dtnb
Domain Architecture
Description	Dystrobrevin beta (Beta-dystrobrevin) (DTN-B) (MDTN-B).

TRI68_MOUSE
NC score	0.085299 (rank : 386)	θ value	0.365318 (rank : 388)
Query Neighborhood Hits	471	Target Neighborhood Hits	356	Shared Neighborhood Hits	103
SwissProt Accessions	Q8K243	Gene names	Trim68, Rnf137
Domain Architecture	No domain graphic available
Description	Tripartite motif containing protein 68 (Ring finger protein 137).

MDM4_HUMAN
NC score	0.084537 (rank : 387)	θ value	0.00869519 (rank : 305)
Query Neighborhood Hits	471	Target Neighborhood Hits	37	Shared Neighborhood Hits	25
SwissProt Accessions	O15151, Q6GS18, Q8IV83	Gene names	MDM4, MDMX
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

TRI65_HUMAN
NC score	0.083989 (rank : 388)	θ value	θ > 10 (rank : 524)
Query Neighborhood Hits	471	Target Neighborhood Hits	330	Shared Neighborhood Hits	103
SwissProt Accessions	Q6PJ69, Q4G0F0, Q6DKJ6, Q9BRP6	Gene names	TRIM65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

ZN179_HUMAN
NC score	0.083530 (rank : 389)	θ value	0.279714 (rank : 383)
Query Neighborhood Hits	471	Target Neighborhood Hits	178	Shared Neighborhood Hits	79
SwissProt Accessions	Q9ULX5, O60633	Gene names	ZNF179, BFP, RNF112
Domain Architecture
Description	Zinc finger protein 179 (Brain finger protein) (RING finger protein 112).

TRPC3_HUMAN
NC score	0.081705 (rank : 390)	θ value	θ > 10 (rank : 532)
Query Neighborhood Hits	471	Target Neighborhood Hits	137	Shared Neighborhood Hits	86
SwissProt Accessions	Q13507, O00593, Q15660	Gene names	TRPC3, TRP3
Domain Architecture
Description	Short transient receptor potential channel 3 (TrpC3) (Htrp-3) (Htrp3).

TRI43_HUMAN
NC score	0.080867 (rank : 391)	θ value	θ > 10 (rank : 516)
Query Neighborhood Hits	471	Target Neighborhood Hits	341	Shared Neighborhood Hits	107
SwissProt Accessions	Q96BQ3	Gene names	TRIM43
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 43.

TRI27_MOUSE
NC score	0.080604 (rank : 392)	θ value	0.163984 (rank : 369)
Query Neighborhood Hits	471	Target Neighborhood Hits	261	Shared Neighborhood Hits	104
SwissProt Accessions	Q62158, Q62157, Q8C2Q5, Q99LK1	Gene names	Trim27, Rfp
Domain Architecture
Description	Zinc finger protein RFP (Ret finger protein) (Tripartite motif- containing protein 27).

TRI27_HUMAN
NC score	0.080225 (rank : 393)	θ value	0.163984 (rank : 368)
Query Neighborhood Hits	471	Target Neighborhood Hits	273	Shared Neighborhood Hits	104
SwissProt Accessions	P14373, Q5ST26, Q6LA73, Q6NXR9, Q9BZY6, Q9UJL3	Gene names	TRIM27, RFP, RNF76
Domain Architecture
Description	Zinc finger protein RFP (Ret finger protein) (Tripartite motif- containing protein 27) (RING finger protein 76).

TRI10_HUMAN
NC score	0.079347 (rank : 394)	θ value	1.38821 (rank : 408)
Query Neighborhood Hits	471	Target Neighborhood Hits	315	Shared Neighborhood Hits	94
SwissProt Accessions	Q9UDY6, Q86Z08, Q96QB6, Q9C023, Q9C024	Gene names	TRIM10, RFB30, RNF9
Domain Architecture
Description	Tripartite motif-containing protein 10 (RING finger protein 9) (B30- RING finger protein).

TRI11_MOUSE
NC score	0.079036 (rank : 395)	θ value	θ > 10 (rank : 505)
Query Neighborhood Hits	471	Target Neighborhood Hits	329	Shared Neighborhood Hits	108
SwissProt Accessions	Q99PQ2, Q8VDX5	Gene names	Trim11
Domain Architecture
Description	Tripartite motif-containing protein 11 (EC 6.3.2.-).

TRI11_HUMAN
NC score	0.079024 (rank : 396)	θ value	θ > 10 (rank : 504)
Query Neighborhood Hits	471	Target Neighborhood Hits	316	Shared Neighborhood Hits	108
SwissProt Accessions	Q96F44, Q8NCA6, Q9C022	Gene names	TRIM11, RNF92
Domain Architecture
Description	Tripartite motif-containing protein 11 (EC 6.3.2.-) (RING finger protein 92) (Protein BIA1).

TRI17_MOUSE
NC score	0.078417 (rank : 397)	θ value	θ > 10 (rank : 509)
Query Neighborhood Hits	471	Target Neighborhood Hits	620	Shared Neighborhood Hits	108
SwissProt Accessions	Q7TPM3, Q99PP8	Gene names	Trim17
Domain Architecture
Description	Tripartite motif-containing protein 17.

TRPC6_MOUSE
NC score	0.078309 (rank : 398)	θ value	4.03905 (rank : 437)
Query Neighborhood Hits	471	Target Neighborhood Hits	171	Shared Neighborhood Hits	94
SwissProt Accessions	Q61143, Q9Z2J1	Gene names	Trpc6, Trp6, Trrp6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6) (Calcium entry channel).

TRI10_MOUSE
NC score	0.078076 (rank : 399)	θ value	3.0926 (rank : 428)
Query Neighborhood Hits	471	Target Neighborhood Hits	285	Shared Neighborhood Hits	99
SwissProt Accessions	Q9WUH5, Q80WA9, Q9CY03	Gene names	Trim10, Herf1, Rnf9
Domain Architecture
Description	Tripartite motif-containing protein 10 (RING finger protein 9) (Hematopoietic RING finger 1).

TRI15_HUMAN
NC score	0.077791 (rank : 400)	θ value	0.279714 (rank : 382)
Query Neighborhood Hits	471	Target Neighborhood Hits	395	Shared Neighborhood Hits	88
SwissProt Accessions	Q9C019, O95604, Q8IUX9, Q9C018	Gene names	TRIM15, RNF93, ZNF178, ZNFB7
Domain Architecture
Description	Tripartite motif-containing protein 15 (Zinc finger protein B7) (RING finger protein 93) (Zinc finger protein 178).

TRI65_MOUSE
NC score	0.076518 (rank : 401)	θ value	θ > 10 (rank : 525)
Query Neighborhood Hits	471	Target Neighborhood Hits	340	Shared Neighborhood Hits	106
SwissProt Accessions	Q8BFW4, Q6PGD3	Gene names	Trim65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

TRI41_HUMAN
NC score	0.076146 (rank : 402)	θ value	0.62314 (rank : 393)
Query Neighborhood Hits	471	Target Neighborhood Hits	349	Shared Neighborhood Hits	83
SwissProt Accessions	Q8WV44, Q5BKT0, Q7L484, Q96Q10, Q9BSL8	Gene names	TRIM41
Domain Architecture
Description	Tripartite motif-containing protein 41.

TRI17_HUMAN
NC score	0.075695 (rank : 403)	θ value	θ > 10 (rank : 508)
Query Neighborhood Hits	471	Target Neighborhood Hits	318	Shared Neighborhood Hits	105
SwissProt Accessions	Q9Y577	Gene names	TRIM17, RBCC, RNF16, TERF
Domain Architecture
Description	Tripartite motif-containing protein 17 (Testis RING finger protein) (RING finger protein 16).

TRPC3_MOUSE
NC score	0.075406 (rank : 404)	θ value	θ > 10 (rank : 533)
Query Neighborhood Hits	471	Target Neighborhood Hits	131	Shared Neighborhood Hits	82
SwissProt Accessions	Q9QZC1, Q61058	Gene names	Trpc3, Trp3, Trrp3
Domain Architecture
Description	Short transient receptor potential channel 3 (TrpC3) (Transient receptor protein 3) (Mtrp3) (Receptor-activated cation channel TRP3) (trp-related protein 3).

TRI38_HUMAN
NC score	0.075247 (rank : 405)	θ value	5.27518 (rank : 441)
Query Neighborhood Hits	471	Target Neighborhood Hits	373	Shared Neighborhood Hits	89
SwissProt Accessions	O00635	Gene names	TRIM38, RNF15, RORET
Domain Architecture
Description	Tripartite motif-containing protein 38 (RING finger protein 15) (Zinc finger protein RoRet).

RNF5_HUMAN
NC score	0.074951 (rank : 406)	θ value	4.03905 (rank : 433)
Query Neighborhood Hits	471	Target Neighborhood Hits	206	Shared Neighborhood Hits	90
SwissProt Accessions	Q99942, Q9UMQ2	Gene names	RNF5, G16, NG2, RMA1
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (HsRma1) (RING finger protein 5) (Protein G16).

RNF5_MOUSE
NC score	0.074926 (rank : 407)	θ value	4.03905 (rank : 434)
Query Neighborhood Hits	471	Target Neighborhood Hits	206	Shared Neighborhood Hits	89
SwissProt Accessions	O35445	Gene names	Rnf5, Ng2
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase RMA1 (EC 6.3.2.-) (RING finger protein 5).

CBLC_MOUSE
NC score	0.073536 (rank : 408)	θ value	0.163984 (rank : 365)
Query Neighborhood Hits	471	Target Neighborhood Hits	186	Shared Neighborhood Hits	82
SwissProt Accessions	Q80XL1, Q99PB6, Q9D6L2, Q9D7A9	Gene names	Cblc, Cbl3
Domain Architecture	No domain graphic available
Description	Signal transduction protein CBL-C (SH3-binding protein CBL-C) (CBL-3).

NBR1_HUMAN
NC score	0.072853 (rank : 409)	θ value	0.0330416 (rank : 335)
Query Neighborhood Hits	471	Target Neighborhood Hits	105	Shared Neighborhood Hits	23
SwissProt Accessions	Q14596, Q13173, Q15026, Q96GB6, Q9NRF7	Gene names	NBR1, 1A13B, KIAA0049, M17S2
Domain Architecture
Description	Next to BRCA1 gene 1 protein (Neighbor of BRCA1 gene 1 protein) (Membrane component, chromosome 17, surface marker 2) (1A1-3B).

TRI25_MOUSE
NC score	0.072842 (rank : 410)	θ value	0.21417 (rank : 380)
Query Neighborhood Hits	471	Target Neighborhood Hits	446	Shared Neighborhood Hits	110
SwissProt Accessions	Q61510	Gene names	Trim25, Efp, Zfp147, Znf147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp).

CBLB_MOUSE
NC score	0.072794 (rank : 411)	θ value	0.125558 (rank : 362)
Query Neighborhood Hits	471	Target Neighborhood Hits	277	Shared Neighborhood Hits	95
SwissProt Accessions	Q3TTA7	Gene names	Cblb
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b).

DTX3_MOUSE
NC score	0.071718 (rank : 412)	θ value	0.813845 (rank : 402)
Query Neighborhood Hits	471	Target Neighborhood Hits	202	Shared Neighborhood Hits	78
SwissProt Accessions	Q80V91, Q9ER06	Gene names	Dtx3
Domain Architecture
Description	Protein deltex-3 (Deltex-3) (Deltex3) (mDTX3).

RN166_HUMAN
NC score	0.071598 (rank : 413)	θ value	θ > 10 (rank : 491)
Query Neighborhood Hits	471	Target Neighborhood Hits	240	Shared Neighborhood Hits	98
SwissProt Accessions	Q96A37, Q96DM0	Gene names	RNF166
Domain Architecture	No domain graphic available
Description	RING finger protein 166.

TRI62_HUMAN
NC score	0.071321 (rank : 414)	θ value	θ > 10 (rank : 522)
Query Neighborhood Hits	471	Target Neighborhood Hits	584	Shared Neighborhood Hits	100
SwissProt Accessions	Q9BVG3, Q9NVG0	Gene names	TRIM62
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 62.

TRPC7_MOUSE
NC score	0.071158 (rank : 415)	θ value	8.99809 (rank : 470)
Query Neighborhood Hits	471	Target Neighborhood Hits	114	Shared Neighborhood Hits	77
SwissProt Accessions	Q9WVC5	Gene names	Trpc7, Trp7, Trrp8
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (mTRP7).

TRPC7_HUMAN
NC score	0.070981 (rank : 416)	θ value	8.99809 (rank : 469)
Query Neighborhood Hits	471	Target Neighborhood Hits	123	Shared Neighborhood Hits	77
SwissProt Accessions	Q9HCX4	Gene names	TRPC7, TRP7
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (TRP7 protein).

TRIM7_MOUSE
NC score	0.070933 (rank : 417)	θ value	θ > 10 (rank : 529)
Query Neighborhood Hits	471	Target Neighborhood Hits	358	Shared Neighborhood Hits	85
SwissProt Accessions	Q923T7, Q5NCB6, Q99PQ5	Gene names	Trim7, Gnip
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein).

TRI55_HUMAN
NC score	0.070774 (rank : 418)	θ value	0.62314 (rank : 397)
Query Neighborhood Hits	471	Target Neighborhood Hits	292	Shared Neighborhood Hits	77
SwissProt Accessions	Q9BYV6, Q53XX3, Q8IUD9, Q8IUE4, Q96DV2, Q96DV3, Q9BYV5	Gene names	TRIM55, MURF2, RNF29
Domain Architecture
Description	Tripartite motif-containing protein 55 (Muscle-specific RING finger protein 2) (MuRF2) (MURF-2) (RING finger protein 29).

TRIM7_HUMAN
NC score	0.070236 (rank : 419)	θ value	θ > 10 (rank : 528)
Query Neighborhood Hits	471	Target Neighborhood Hits	336	Shared Neighborhood Hits	85
SwissProt Accessions	Q9C029, Q969F5, Q96F67, Q96J89, Q96J90	Gene names	TRIM7, GNIP, RNF90
Domain Architecture
Description	Tripartite motif-containing protein 7 (Glycogenin-interacting protein) (RING finger protein 90).

TRI62_MOUSE
NC score	0.070095 (rank : 420)	θ value	θ > 10 (rank : 523)
Query Neighborhood Hits	471	Target Neighborhood Hits	478	Shared Neighborhood Hits	95
SwissProt Accessions	Q80V85	Gene names	Trim62
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 62.

RN166_MOUSE
NC score	0.070026 (rank : 421)	θ value	θ > 10 (rank : 492)
Query Neighborhood Hits	471	Target Neighborhood Hits	248	Shared Neighborhood Hits	98
SwissProt Accessions	Q3U9F6	Gene names	Rnf166
Domain Architecture	No domain graphic available
Description	RING finger protein 166.

ZN313_MOUSE
NC score	0.069778 (rank : 422)	θ value	θ > 10 (rank : 537)
Query Neighborhood Hits	471	Target Neighborhood Hits	273	Shared Neighborhood Hits	105
SwissProt Accessions	Q9ET26, Q3UFU8, Q8K5A2	Gene names	Znf313, Zfp228, Zfp313, Znf228
Domain Architecture
Description	Zinc finger protein 313.

MDM2_HUMAN
NC score	0.069480 (rank : 423)	θ value	0.365318 (rank : 386)
Query Neighborhood Hits	471	Target Neighborhood Hits	92	Shared Neighborhood Hits	31
SwissProt Accessions	Q00987, Q13226, Q13297, Q13298, Q13299, Q13300, Q13301, Q53XW0, Q71TW9, Q9UGI3, Q9UMT8	Gene names	MDM2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2).

RN168_HUMAN
NC score	0.068946 (rank : 424)	θ value	θ > 10 (rank : 493)
Query Neighborhood Hits	471	Target Neighborhood Hits	370	Shared Neighborhood Hits	108
SwissProt Accessions	Q8IYW5, Q8NA67, Q96NS4	Gene names	RNF168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

TRI48_HUMAN
NC score	0.068910 (rank : 425)	θ value	θ > 10 (rank : 517)
Query Neighborhood Hits	471	Target Neighborhood Hits	192	Shared Neighborhood Hits	80
SwissProt Accessions	Q8IWZ4, Q9BUW4	Gene names	TRIM48, RNF101
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 48 (RING finger protein 101).

TRI60_MOUSE
NC score	0.068903 (rank : 426)	θ value	θ > 10 (rank : 521)
Query Neighborhood Hits	471	Target Neighborhood Hits	240	Shared Neighborhood Hits	78
SwissProt Accessions	Q8VI40, Q3UX74	Gene names	Trim60, 2czf45, Rnf33
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 60 (Ring finger protein 33).

CBL_HUMAN
NC score	0.068829 (rank : 427)	θ value	0.813845 (rank : 400)
Query Neighborhood Hits	471	Target Neighborhood Hits	353	Shared Neighborhood Hits	97
SwissProt Accessions	P22681	Gene names	CBL, CBL2, RNF55
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene) (RING finger protein 55).

REL_MOUSE
NC score	0.068644 (rank : 428)	θ value	θ > 10 (rank : 488)
Query Neighborhood Hits	471	Target Neighborhood Hits	77	Shared Neighborhood Hits	5
SwissProt Accessions	P15307	Gene names	Rel
Domain Architecture
Description	C-Rel proto-oncogene protein (C-Rel protein).

CBLB_HUMAN
NC score	0.068140 (rank : 429)	θ value	0.365318 (rank : 385)
Query Neighborhood Hits	471	Target Neighborhood Hits	261	Shared Neighborhood Hits	93
SwissProt Accessions	Q13191, Q13192, Q13193, Q3LIC0, Q8IVC5	Gene names	CBLB, RNF56
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL-B (EC 6.3.2.-) (Signal transduction protein CBL-B) (SH3-binding protein CBL-B) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56).

REL_HUMAN
NC score	0.068118 (rank : 430)	θ value	θ > 10 (rank : 487)
Query Neighborhood Hits	471	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q04864, Q2PNZ7, Q6LDY0	Gene names	REL
Domain Architecture
Description	C-Rel proto-oncogene protein (C-Rel protein).

CBL_MOUSE
NC score	0.067960 (rank : 431)	θ value	0.813845 (rank : 401)
Query Neighborhood Hits	471	Target Neighborhood Hits	426	Shared Neighborhood Hits	97
SwissProt Accessions	P22682, Q8CEA1	Gene names	Cbl
Domain Architecture
Description	E3 ubiquitin-protein ligase CBL (EC 6.3.2.-) (Signal transduction protein CBL) (Proto-oncogene c-CBL) (Casitas B-lineage lymphoma proto- oncogene).

TRI13_MOUSE
NC score	0.067427 (rank : 432)	θ value	θ > 10 (rank : 507)
Query Neighborhood Hits	471	Target Neighborhood Hits	282	Shared Neighborhood Hits	91
SwissProt Accessions	Q9CYB0, Q8CEV0, Q923J0, Q925P1, Q99PQ0	Gene names	Trim13, Rfp2
Domain Architecture
Description	Tripartite motif-containing protein 13 (Ret finger protein 2) (Putative tumor suppressor RFP2).

LRRK1_HUMAN
NC score	0.067279 (rank : 433)	θ value	0.0330416 (rank : 334)
Query Neighborhood Hits	471	Target Neighborhood Hits	1237	Shared Neighborhood Hits	98
SwissProt Accessions	Q38SD2, Q6NVH5, Q6NYC0, Q6ZNL9, Q6ZNM9, Q96JN5, Q9H5S3	Gene names	LRRK1, KIAA1790
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat serine/threonine-protein kinase 1 (EC 2.7.11.1).

TRPC4_MOUSE
NC score	0.067232 (rank : 434)	θ value	1.81305 (rank : 417)
Query Neighborhood Hits	471	Target Neighborhood Hits	141	Shared Neighborhood Hits	80
SwissProt Accessions	Q9QUQ5, Q62350, Q9QUQ9, Q9QZC0	Gene names	Trpc4, Trrp4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (Receptor- activated cation channel TRP4) (Capacitative calcium entry channel Trp4).

TRPC4_HUMAN
NC score	0.067151 (rank : 435)	θ value	1.81305 (rank : 416)
Query Neighborhood Hits	471	Target Neighborhood Hits	140	Shared Neighborhood Hits	80
SwissProt Accessions	Q9UBN4, Q15721, Q9UIB0, Q9UIB1, Q9UIB2	Gene names	TRPC4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (trp-related protein 4) (hTrp-4) (hTrp4).

RNF4_HUMAN
NC score	0.066955 (rank : 436)	θ value	θ > 10 (rank : 498)
Query Neighborhood Hits	471	Target Neighborhood Hits	212	Shared Neighborhood Hits	80
SwissProt Accessions	P78317	Gene names	RNF4
Domain Architecture
Description	RING finger protein 4.

RELB_MOUSE
NC score	0.066792 (rank : 437)	θ value	θ > 10 (rank : 486)
Query Neighborhood Hits	471	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q04863	Gene names	Relb
Domain Architecture
Description	Transcription factor RelB.

TRI13_HUMAN
NC score	0.066782 (rank : 438)	θ value	θ > 10 (rank : 506)
Query Neighborhood Hits	471	Target Neighborhood Hits	274	Shared Neighborhood Hits	89
SwissProt Accessions	O60858, Q9BQ47, Q9C021	Gene names	TRIM13, LEU5, RFP2, RNF77
Domain Architecture
Description	Tripartite motif-containing protein 13 (Ret finger protein 2) (Putative tumor suppressor RFP2) (Leukemia-associated protein 5) (B- cell chronic lymphocytic leukemia tumor suppressor Leu5) (RING finger protein 77).

RELB_HUMAN
NC score	0.066757 (rank : 439)	θ value	θ > 10 (rank : 485)
Query Neighborhood Hits	471	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	Q01201, Q6GTX7, Q9UEI7	Gene names	RELB
Domain Architecture
Description	Transcription factor RelB (I-Rel).

RNF4_MOUSE
NC score	0.066668 (rank : 440)	θ value	θ > 10 (rank : 499)
Query Neighborhood Hits	471	Target Neighborhood Hits	212	Shared Neighborhood Hits	80
SwissProt Accessions	Q9QZS2, O35941, Q541Z6	Gene names	Rnf4
Domain Architecture
Description	RING finger protein 4.

MDM2_MOUSE
NC score	0.066393 (rank : 441)	θ value	0.21417 (rank : 373)
Query Neighborhood Hits	471	Target Neighborhood Hits	77	Shared Neighborhood Hits	31
SwissProt Accessions	P23804, Q61040, Q64330	Gene names	Mdm2
Domain Architecture
Description	Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2.-) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein).

TRI47_MOUSE
NC score	0.066270 (rank : 442)	θ value	8.99809 (rank : 468)
Query Neighborhood Hits	471	Target Neighborhood Hits	295	Shared Neighborhood Hits	92
SwissProt Accessions	Q8C0E3, Q6P249, Q811J7, Q8BVZ8, Q8R1K0, Q8R3Y1	Gene names	Trim47
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47.

TF65_MOUSE
NC score	0.066268 (rank : 443)	θ value	θ > 10 (rank : 503)
Query Neighborhood Hits	471	Target Neighborhood Hits	66	Shared Neighborhood Hits	6
SwissProt Accessions	Q04207, Q62025	Gene names	Rela, Nfkb3
Domain Architecture
Description	Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit).

CBLC_HUMAN
NC score	0.066267 (rank : 444)	θ value	1.06291 (rank : 404)
Query Neighborhood Hits	471	Target Neighborhood Hits	173	Shared Neighborhood Hits	81
SwissProt Accessions	Q9ULV8, Q8N1E5, Q9Y5Z2, Q9Y5Z3	Gene names	CBLC, CBL3, RNF57
Domain Architecture
Description	Signal transduction protein CBL-C (SH3-binding protein CBL-C) (CBL-3) (RING finger protein 57).

TRPC5_MOUSE
NC score	0.065854 (rank : 445)	θ value	θ > 10 (rank : 535)
Query Neighborhood Hits	471	Target Neighborhood Hits	124	Shared Neighborhood Hits	78
SwissProt Accessions	Q9QX29, Q61059, Q9QWT1, Q9R0D4	Gene names	Trpc5, Trp5, Trrp5
Domain Architecture
Description	Short transient receptor potential channel 5 (TrpC5) (Transient receptor protein 5) (Mtrp5) (trp-related protein 5) (Capacitative calcium entry channel 2) (CCE2).

TRI63_HUMAN
NC score	0.065708 (rank : 446)	θ value	5.27518 (rank : 442)
Query Neighborhood Hits	471	Target Neighborhood Hits	298	Shared Neighborhood Hits	79
SwissProt Accessions	Q969Q1, Q5T2I1, Q96BD3, Q96KD9, Q9BYV4	Gene names	TRIM63, IRF, MURF1, RNF28, SMRZ
Domain Architecture
Description	Ubiquitin ligase TRIM63 (EC 6.3.2.-) (Tripartite motif-containing protein 63) (Muscle-specific RING finger protein 1) (MuRF1) (MURF-1) (RING finger protein 28) (Striated muscle RING zinc finger protein) (Iris RING finger protein).

TF65_HUMAN
NC score	0.065494 (rank : 447)	θ value	θ > 10 (rank : 502)
Query Neighborhood Hits	471	Target Neighborhood Hits	115	Shared Neighborhood Hits	7
SwissProt Accessions	Q04206, Q6SLK1	Gene names	RELA, NFKB3
Domain Architecture
Description	Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit).

ZN313_HUMAN
NC score	0.065467 (rank : 448)	θ value	θ > 10 (rank : 536)
Query Neighborhood Hits	471	Target Neighborhood Hits	264	Shared Neighborhood Hits	103
SwissProt Accessions	Q9Y508, Q6N0B0	Gene names	ZNF313, RNF114, ZNF228
Domain Architecture
Description	Zinc finger protein 313 (RING finger protein 114).

TRIM8_HUMAN
NC score	0.065297 (rank : 449)	θ value	θ > 10 (rank : 530)
Query Neighborhood Hits	471	Target Neighborhood Hits	650	Shared Neighborhood Hits	93
SwissProt Accessions	Q9BZR9, Q9C028	Gene names	TRIM8, GERP, RNF27
Domain Architecture
Description	Tripartite motif-containing protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein).

TRI47_HUMAN
NC score	0.065288 (rank : 450)	θ value	8.99809 (rank : 467)
Query Neighborhood Hits	471	Target Neighborhood Hits	286	Shared Neighborhood Hits	90
SwissProt Accessions	Q96LD4, Q96GU5, Q9BRN7	Gene names	TRIM47, GOA, RNF100
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 47 (Gene overexpressed in astrocytoma protein) (RING finger protein 100).

DRP2_HUMAN
NC score	0.065183 (rank : 451)	θ value	0.0193708 (rank : 322)
Query Neighborhood Hits	471	Target Neighborhood Hits	186	Shared Neighborhood Hits	16
SwissProt Accessions	Q13474	Gene names	DRP2
Domain Architecture
Description	Dystrophin-related protein 2.

DTX3_HUMAN
NC score	0.064700 (rank : 452)	θ value	3.0926 (rank : 424)
Query Neighborhood Hits	471	Target Neighborhood Hits	198	Shared Neighborhood Hits	76
SwissProt Accessions	Q8N9I9, Q8NAU6, Q8NDS8	Gene names	DTX3
Domain Architecture
Description	Protein deltex-3 (Deltex-3) (Deltex3).

NBR1_MOUSE
NC score	0.064685 (rank : 453)	θ value	0.21417 (rank : 374)
Query Neighborhood Hits	471	Target Neighborhood Hits	116	Shared Neighborhood Hits	18
SwissProt Accessions	P97432, Q9JIH9	Gene names	Nbr1, M17s2
Domain Architecture
Description	Next to BRCA1 gene 1 protein (Neighbor of BRCA1 gene 1 protein) (Membrane component, chromosome 17, surface marker 2).

TRI49_HUMAN
NC score	0.064475 (rank : 454)	θ value	θ > 10 (rank : 518)
Query Neighborhood Hits	471	Target Neighborhood Hits	199	Shared Neighborhood Hits	71
SwissProt Accessions	Q9NS80, Q6DJV1	Gene names	TRIM49, RNF18
Domain Architecture
Description	Tripartite motif-containing protein 49 (RING finger protein 18) (Testis-specific ring-finger protein).

TRPC5_HUMAN
NC score	0.064472 (rank : 455)	θ value	θ > 10 (rank : 534)
Query Neighborhood Hits	471	Target Neighborhood Hits	122	Shared Neighborhood Hits	76
SwissProt Accessions	Q9UL62, O75233, Q5JXY8, Q9Y514	Gene names	TRPC5, TRP5
Domain Architecture
Description	Short transient receptor potential channel 5 (TrpC5) (Htrp-5) (Htrp5).

MDM4_MOUSE
NC score	0.064116 (rank : 456)	θ value	0.0431538 (rank : 345)
Query Neighborhood Hits	471	Target Neighborhood Hits	36	Shared Neighborhood Hits	19
SwissProt Accessions	O35618	Gene names	Mdm4, Mdmx
Domain Architecture
Description	Mdm4 protein (p53-binding protein Mdm4) (Mdm2-like p53-binding protein) (Mdmx protein) (Double minute 4 protein).

TRIM8_MOUSE
NC score	0.064084 (rank : 457)	θ value	θ > 10 (rank : 531)
Query Neighborhood Hits	471	Target Neighborhood Hits	674	Shared Neighborhood Hits	94
SwissProt Accessions	Q99PJ2, Q8C508, Q8C700, Q8CGI2, Q99PQ4	Gene names	Trim8, Gerp, Rnf27
Domain Architecture
Description	Tripartite motif-containing protein 8 (RING finger protein 27) (Glioblastoma-expressed RING finger protein).

RN168_MOUSE
NC score	0.064078 (rank : 458)	θ value	θ > 10 (rank : 494)
Query Neighborhood Hits	471	Target Neighborhood Hits	440	Shared Neighborhood Hits	104
SwissProt Accessions	Q80XJ2	Gene names	Rnf168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

TRI63_MOUSE
NC score	0.063763 (rank : 459)	θ value	5.27518 (rank : 443)
Query Neighborhood Hits	471	Target Neighborhood Hits	240	Shared Neighborhood Hits	75
SwissProt Accessions	Q38HM4, Q8BWC4	Gene names	Trim63, Murf1, Rf1
Domain Architecture	No domain graphic available
Description	Ubiquitin ligase TRIM63 (EC 6.3.2.-) (Tripartite motif-containing protein 63) (Muscle-specific RING finger protein 1) (MuRF1) (MURF-1) (Muscle RING finger protein 1).

TRI25_HUMAN
NC score	0.063640 (rank : 460)	θ value	θ > 10 (rank : 510)
Query Neighborhood Hits	471	Target Neighborhood Hits	472	Shared Neighborhood Hits	105
SwissProt Accessions	Q14258	Gene names	TRIM25, EFP, RNF147, ZNF147
Domain Architecture
Description	Tripartite motif-containing protein 25 (Zinc finger protein 147) (Estrogen-responsive finger protein) (Efp) (RING finger protein 147).

TRI59_MOUSE
NC score	0.061722 (rank : 461)	θ value	θ > 10 (rank : 520)
Query Neighborhood Hits	471	Target Neighborhood Hits	292	Shared Neighborhood Hits	86
SwissProt Accessions	Q922Y2, Q9CSP2, Q9CUD5, Q9D740	Gene names	Trim59, Mrf1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 59 (RING finger protein 1).

TRI59_HUMAN
NC score	0.061530 (rank : 462)	θ value	θ > 10 (rank : 519)
Query Neighborhood Hits	471	Target Neighborhood Hits	307	Shared Neighborhood Hits	85
SwissProt Accessions	Q8IWR1	Gene names	TRIM59, RNF104, TRIM57, TSBF1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 59 (Tumor suppressor TSBF-1) (RING finger protein 104).

TRI54_HUMAN
NC score	0.060459 (rank : 463)	θ value	6.88961 (rank : 448)
Query Neighborhood Hits	471	Target Neighborhood Hits	209	Shared Neighborhood Hits	77
SwissProt Accessions	Q9BYV2, Q53SY4, Q9BYV3	Gene names	TRIM54, MURF, MURF3, RNF30
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 54 (Muscle-specific RING finger protein 3) (MuRF3) (MURF-3) (Muscle-specific RING finger protein) (MuRF) (RING finger protein 30).

TRI54_MOUSE
NC score	0.060340 (rank : 464)	θ value	6.88961 (rank : 449)
Query Neighborhood Hits	471	Target Neighborhood Hits	197	Shared Neighborhood Hits	75
SwissProt Accessions	Q9ERP3	Gene names	Trim54, Murf, Rnf30
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 54 (Muscle-specific RING finger protein 3) (MuRF3) (MURF-3) (Muscle-specific RING finger protein) (MuRF) (RING finger protein 30).

TRI46_HUMAN
NC score	0.058188 (rank : 465)	θ value	0.62314 (rank : 395)
Query Neighborhood Hits	471	Target Neighborhood Hits	291	Shared Neighborhood Hits	87
SwissProt Accessions	Q7Z4K8, Q6NT17, Q6NT41, Q6ZRL7, Q9H5P2	Gene names	TRIM46, TRIFIC
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 46 (Tripartite, fibronectin type- III and C-terminal SPRY motif protein).

DTX3L_HUMAN
NC score	0.057786 (rank : 466)	θ value	1.38821 (rank : 405)
Query Neighborhood Hits	471	Target Neighborhood Hits	187	Shared Neighborhood Hits	61
SwissProt Accessions	Q8TDB6	Gene names	DTX3L, BBAP
Domain Architecture
Description	Protein deltex 3-like protein (B-lymphoma- and BAL-associated protein) (Rhysin-2) (Rhysin2).

TRI46_MOUSE
NC score	0.057519 (rank : 467)	θ value	0.62314 (rank : 396)
Query Neighborhood Hits	471	Target Neighborhood Hits	287	Shared Neighborhood Hits	86
SwissProt Accessions	Q7TNM2, Q60717, Q6P1I9	Gene names	Trim46, Trific
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 46 (Tripartite, fibronectin type- III and C-terminal SPRY motif protein).

BFAR_HUMAN
NC score	0.057305 (rank : 468)	θ value	θ > 10 (rank : 475)
Query Neighborhood Hits	471	Target Neighborhood Hits	222	Shared Neighborhood Hits	82
SwissProt Accessions	Q9NZS9	Gene names	BFAR, BAR, RNF47
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator (RING finger protein 47).

VPS11_MOUSE
NC score	0.057184 (rank : 469)	θ value	0.0148317 (rank : 320)
Query Neighborhood Hits	471	Target Neighborhood Hits	87	Shared Neighborhood Hits	27
SwissProt Accessions	Q91W86, Q9DBX8	Gene names	Vps11
Domain Architecture
Description	Vacuolar protein sorting-associated protein 11.

MEFV_HUMAN
NC score	0.056955 (rank : 470)	θ value	θ > 10 (rank : 482)
Query Neighborhood Hits	471	Target Neighborhood Hits	431	Shared Neighborhood Hits	57
SwissProt Accessions	O15553, Q96PN4, Q96PN5	Gene names	MEFV, MEF
Domain Architecture
Description	Pyrin (Marenostrin).

TRI32_HUMAN
NC score	0.056938 (rank : 471)	θ value	θ > 10 (rank : 511)
Query Neighborhood Hits	471	Target Neighborhood Hits	264	Shared Neighborhood Hits	84
SwissProt Accessions	Q13049, Q9NQP8	Gene names	TRIM32, HT2A
Domain Architecture
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-) (Zinc finger protein HT2A) (72 kDa Tat-interacting protein).

VPS11_HUMAN
NC score	0.056915 (rank : 472)	θ value	0.0148317 (rank : 319)
Query Neighborhood Hits	471	Target Neighborhood Hits	86	Shared Neighborhood Hits	27
SwissProt Accessions	Q9H270, Q8WY89, Q96EP8, Q9H6D9, Q9HCS6	Gene names	VPS11, RNF108
Domain Architecture
Description	Vacuolar protein sorting-associated protein 11 (hVPS11) (RING finger protein 108).

TRIM1_HUMAN
NC score	0.056816 (rank : 473)	θ value	2.36792 (rank : 422)
Query Neighborhood Hits	471	Target Neighborhood Hits	345	Shared Neighborhood Hits	101
SwissProt Accessions	Q9UJV3, Q5JYF5, Q8WWK1, Q9UJR9	Gene names	MID2, FXY2, RNF60, TRIM1
Domain Architecture
Description	Midline-2 (Midline defect 2) (Tripartite motif-containing protein 1) (Midin-2) (RING finger protein 60).

TRI32_MOUSE
NC score	0.056696 (rank : 474)	θ value	θ > 10 (rank : 512)
Query Neighborhood Hits	471	Target Neighborhood Hits	271	Shared Neighborhood Hits	86
SwissProt Accessions	Q8CH72, Q8K055	Gene names	Trim32
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 32 (EC 6.3.2.-).

TRIM2_HUMAN
NC score	0.056521 (rank : 475)	θ value	3.0926 (rank : 429)
Query Neighborhood Hits	471	Target Neighborhood Hits	330	Shared Neighborhood Hits	98
SwissProt Accessions	Q9C040, O60272, Q9BSI9, Q9UFZ1	Gene names	TRIM2, KIAA0517, RNF86
Domain Architecture
Description	Tripartite motif-containing protein 2 (RING finger protein 86).

BFAR_MOUSE
NC score	0.056339 (rank : 476)	θ value	θ > 10 (rank : 476)
Query Neighborhood Hits	471	Target Neighborhood Hits	232	Shared Neighborhood Hits	85
SwissProt Accessions	Q8R079, Q8C1A7, Q9CXY3	Gene names	Bfar
Domain Architecture	No domain graphic available
Description	Bifunctional apoptosis regulator.

MEFV_MOUSE
NC score	0.055922 (rank : 477)	θ value	θ > 10 (rank : 483)
Query Neighborhood Hits	471	Target Neighborhood Hits	236	Shared Neighborhood Hits	54
SwissProt Accessions	Q9JJ26	Gene names	Mefv
Domain Architecture
Description	Pyrin (Marenostrin).

TRIM1_MOUSE
NC score	0.055896 (rank : 478)	θ value	2.36792 (rank : 423)
Query Neighborhood Hits	471	Target Neighborhood Hits	361	Shared Neighborhood Hits	101
SwissProt Accessions	Q9QUS6	Gene names	Mid2, Fxy2, Trim1
Domain Architecture
Description	Midline-2 (Midline defect 2) (Tripartite motif-containing protein 1).

TRI18_MOUSE
NC score	0.055810 (rank : 479)	θ value	2.36792 (rank : 421)
Query Neighborhood Hits	471	Target Neighborhood Hits	292	Shared Neighborhood Hits	96
SwissProt Accessions	O70583, O35418, Q7TPT6	Gene names	Mid1, Fxy, Trim18
Domain Architecture
Description	Midline-1 (EC 6.3.2.-) (Tripartite motif-containing protein 18) (Midin).

TRIM2_MOUSE
NC score	0.055682 (rank : 480)	θ value	4.03905 (rank : 435)
Query Neighborhood Hits	471	Target Neighborhood Hits	331	Shared Neighborhood Hits	98
SwissProt Accessions	Q9ESN6, Q3UHP5, Q8C981	Gene names	Trim2, Narf
Domain Architecture
Description	Tripartite motif-containing protein 2 (Neural activity-related RING finger protein).

TRI37_HUMAN
NC score	0.055610 (rank : 481)	θ value	θ > 10 (rank : 513)
Query Neighborhood Hits	471	Target Neighborhood Hits	307	Shared Neighborhood Hits	88
SwissProt Accessions	O94972, Q7Z3E6, Q8IYF7, Q8WYF7	Gene names	TRIM37, KIAA0898, MUL, POB1
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37 (Mulibrey nanism protein).

TRI37_MOUSE
NC score	0.055305 (rank : 482)	θ value	θ > 10 (rank : 514)
Query Neighborhood Hits	471	Target Neighborhood Hits	316	Shared Neighborhood Hits	87
SwissProt Accessions	Q6PCX9, Q8CHC5	Gene names	Trim37, Kiaa0898
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 37.

RNF39_HUMAN
NC score	0.055090 (rank : 483)	θ value	θ > 10 (rank : 495)
Query Neighborhood Hits	471	Target Neighborhood Hits	200	Shared Neighborhood Hits	71
SwissProt Accessions	Q9H2S5, Q5SPM8, Q5SPM9, Q5SPN0, Q5SRJ9, Q5SRK1, Q5SS29, Q9H2S3, Q9H2S4	Gene names	RNF39, HZFW
Domain Architecture	No domain graphic available
Description	RING finger protein 39 (Protein HZFw).

TRI18_HUMAN
NC score	0.054819 (rank : 484)	θ value	2.36792 (rank : 420)
Query Neighborhood Hits	471	Target Neighborhood Hits	307	Shared Neighborhood Hits	93
SwissProt Accessions	O15344, O75361, Q9BZX5	Gene names	MID1, FXY, RNF59, TRIM18, XPRF
Domain Architecture
Description	Midline-1 (EC 6.3.2.-) (Tripartite motif-containing protein 18) (Putative transcription factor XPRF) (Midin) (RING finger protein 59) (Midline 1 RING finger protein).

RN125_MOUSE
NC score	0.054444 (rank : 485)	θ value	θ > 10 (rank : 490)
Query Neighborhood Hits	471	Target Neighborhood Hits	220	Shared Neighborhood Hits	88
SwissProt Accessions	Q9D9R0, Q52KL4, Q8C7F2	Gene names	Rnf125
Domain Architecture	No domain graphic available
Description	RING finger protein 125 (EC 6.3.2.-).

EP300_HUMAN
NC score	0.053119 (rank : 486)	θ value	0.0431538 (rank : 344)
Query Neighborhood Hits	471	Target Neighborhood Hits	821	Shared Neighborhood Hits	34
SwissProt Accessions	Q09472	Gene names	EP300, P300
Domain Architecture
Description	E1A-associated protein p300 (EC 2.3.1.48).

RN125_HUMAN
NC score	0.052727 (rank : 487)	θ value	θ > 10 (rank : 489)
Query Neighborhood Hits	471	Target Neighborhood Hits	230	Shared Neighborhood Hits	87
SwissProt Accessions	Q96EQ8, Q9NX39	Gene names	RNF125
Domain Architecture	No domain graphic available
Description	RING finger protein 125 (EC 6.3.2.-) (T-cell RING activation protein 1) (TRAC-1).

BRAP_HUMAN
NC score	0.052605 (rank : 488)	θ value	1.81305 (rank : 411)
Query Neighborhood Hits	471	Target Neighborhood Hits	560	Shared Neighborhood Hits	60
SwissProt Accessions	Q7Z569, O43238, O75341	Gene names	BRAP, RNF52
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP) (RING finger protein 52) (NY-REN-63 antigen).

DMD_HUMAN
NC score	0.052400 (rank : 489)	θ value	0.0431538 (rank : 341)
Query Neighborhood Hits	471	Target Neighborhood Hits	1135	Shared Neighborhood Hits	64
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

UTRO_HUMAN
NC score	0.052398 (rank : 490)	θ value	0.00509761 (rank : 296)
Query Neighborhood Hits	471	Target Neighborhood Hits	960	Shared Neighborhood Hits	47
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

ZC3H5_HUMAN
NC score	0.052235 (rank : 491)	θ value	0.125558 (rank : 364)
Query Neighborhood Hits	471	Target Neighborhood Hits	134	Shared Neighborhood Hits	24
SwissProt Accessions	Q9C0B0	Gene names	ZC3H5, KIAA1753, ZC3HDC5
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 5.

BRE1A_HUMAN
NC score	0.052102 (rank : 492)	θ value	θ > 10 (rank : 477)
Query Neighborhood Hits	471	Target Neighborhood Hits	1071	Shared Neighborhood Hits	96
SwissProt Accessions	Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83	Gene names	RNF20, BRE1A
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (hBRE1) (RING finger protein 20).

TRIM3_HUMAN
NC score	0.051859 (rank : 493)	θ value	θ > 10 (rank : 526)
Query Neighborhood Hits	471	Target Neighborhood Hits	357	Shared Neighborhood Hits	95
SwissProt Accessions	O75382, Q9C038, Q9C039	Gene names	TRIM3, BERP, RNF22, RNF97
Domain Architecture
Description	Tripartite motif-containing protein 3 (RING finger protein 22) (Brain- expressed RING finger protein) (RING finger protein 97).

CBP_MOUSE
NC score	0.051504 (rank : 494)	θ value	0.0961366 (rank : 358)
Query Neighborhood Hits	471	Target Neighborhood Hits	1051	Shared Neighborhood Hits	43
SwissProt Accessions	P45481	Gene names	Crebbp, Cbp
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

DMD_MOUSE
NC score	0.051459 (rank : 495)	θ value	0.0431538 (rank : 342)
Query Neighborhood Hits	471	Target Neighborhood Hits	1111	Shared Neighborhood Hits	56
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

SSB4_HUMAN
NC score	0.051117 (rank : 496)	θ value	θ > 10 (rank : 501)
Query Neighborhood Hits	471	Target Neighborhood Hits	47	Shared Neighborhood Hits	28
SwissProt Accessions	Q96A44	Gene names	SPSB4, SSB4
Domain Architecture	No domain graphic available
Description	SPRY domain-containing SOCS box protein 4 (SSB-4).

CBP_HUMAN
NC score	0.051099 (rank : 497)	θ value	0.0961366 (rank : 357)
Query Neighborhood Hits	471	Target Neighborhood Hits	941	Shared Neighborhood Hits	33
SwissProt Accessions	Q92793, O00147, Q16376	Gene names	CREBBP, CBP
Domain Architecture
Description	CREB-binding protein (EC 2.3.1.48).

TRIM3_MOUSE
NC score	0.050894 (rank : 498)	θ value	θ > 10 (rank : 527)
Query Neighborhood Hits	471	Target Neighborhood Hits	351	Shared Neighborhood Hits	90
SwissProt Accessions	Q9R1R2, Q3UMU5	Gene names	Trim3, Hac1, Rnf22
Domain Architecture
Description	Tripartite motif-containing protein 3 (RING finger protein 22) (RING finger protein HAC1).

TRPC1_HUMAN
NC score	0.050519 (rank : 499)	θ value	0.813845 (rank : 403)
Query Neighborhood Hits	471	Target Neighborhood Hits	91	Shared Neighborhood Hits	56
SwissProt Accessions	P48995	Gene names	TRPC1, TRP1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (TRP-1 protein).

RNF41_MOUSE
NC score	0.050385 (rank : 500)	θ value	θ > 10 (rank : 497)
Query Neighborhood Hits	471	Target Neighborhood Hits	224	Shared Neighborhood Hits	82
SwissProt Accessions	Q8BH75, Q8BGJ2, Q8BMC9, Q8VEA2, Q9CRK6, Q9D568	Gene names	Rnf41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

RAD18_MOUSE
NC score	0.050381 (rank : 501)	θ value	θ > 10 (rank : 484)
Query Neighborhood Hits	471	Target Neighborhood Hits	230	Shared Neighborhood Hits	79
SwissProt Accessions	Q9QXK2, Q9CZB8	Gene names	Rad18, Rad18sc
Domain Architecture
Description	Postreplication repair protein RAD18 (mRAD18Sc).

RNF41_HUMAN
NC score	0.050218 (rank : 502)	θ value	θ > 10 (rank : 496)
Query Neighborhood Hits	471	Target Neighborhood Hits	226	Shared Neighborhood Hits	82
SwissProt Accessions	Q9H4P4, O75598	Gene names	RNF41
Domain Architecture	No domain graphic available
Description	RING finger protein 41.

BRE1B_HUMAN
NC score	0.049610 (rank : 503)	θ value	1.81305 (rank : 413)
Query Neighborhood Hits	471	Target Neighborhood Hits	1040	Shared Neighborhood Hits	110
SwissProt Accessions	O75150, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82	Gene names	RNF40, BRE1B, KIAA0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40) (95 kDa retinoblastoma-associated protein) (RBP95).

BRE1B_MOUSE
NC score	0.048828 (rank : 504)	θ value	1.81305 (rank : 414)
Query Neighborhood Hits	471	Target Neighborhood Hits	970	Shared Neighborhood Hits	108
SwissProt Accessions	Q3U319, Q6ZQ75, Q8BJA1, Q8BY03, Q8CHX4	Gene names	Rnf40, Bre1b, Kiaa0661
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1B (EC 6.3.2.-) (BRE1-B) (RING finger protein 40).

TRI42_MOUSE
NC score	0.048228 (rank : 505)	θ value	0.62314 (rank : 394)
Query Neighborhood Hits	471	Target Neighborhood Hits	316	Shared Neighborhood Hits	66
SwissProt Accessions	Q9D2H5	Gene names	Trim42
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 42.

KRA59_HUMAN
NC score	0.047628 (rank : 506)	θ value	0.0252991 (rank : 324)
Query Neighborhood Hits	471	Target Neighborhood Hits	310	Shared Neighborhood Hits	16
SwissProt Accessions	P26371, Q14564	Gene names	KRTAP5-9, KAP5.9, KRN1, KRTAP5.9, UHSK1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-9 (Keratin-associated protein 5.9) (Ultrahigh sulfur keratin-associated protein 5.9) (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (UHS keratin A) (UHS KerA).

RN123_MOUSE
NC score	0.044912 (rank : 507)	θ value	2.36792 (rank : 419)
Query Neighborhood Hits	471	Target Neighborhood Hits	174	Shared Neighborhood Hits	73
SwissProt Accessions	Q5XPI3, Q6PGE0	Gene names	Rnf123, Kpc1
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase subunit KPC1 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123).

TRPC1_MOUSE
NC score	0.044610 (rank : 508)	θ value	1.38821 (rank : 409)
Query Neighborhood Hits	471	Target Neighborhood Hits	87	Shared Neighborhood Hits	52
SwissProt Accessions	Q61056, O35722	Gene names	Trpc1, Trp1, Trrp1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (Mtrp1) (Trp-related protein 1).

BRAP_MOUSE
NC score	0.044110 (rank : 509)	θ value	1.81305 (rank : 412)
Query Neighborhood Hits	471	Target Neighborhood Hits	409	Shared Neighborhood Hits	49
SwissProt Accessions	Q99MP8, Q8CC00, Q8CHX1, Q99MP7, Q9CXX8	Gene names	Brap
Domain Architecture	No domain graphic available
Description	BRCA1-associated protein (EC 6.3.2.-) (BRAP2) (Impedes mitogenic signal propagation) (IMP).

RFWD2_MOUSE
NC score	0.042054 (rank : 510)	θ value	1.38821 (rank : 407)
Query Neighborhood Hits	471	Target Neighborhood Hits	535	Shared Neighborhood Hits	100
SwissProt Accessions	Q9R1A8	Gene names	Rfwd2, Cop1
Domain Architecture	No domain graphic available
Description	RING finger and WD repeat domain protein 2 (EC 6.3.2.-) (Ubiquitin- protein ligase COP1) (Constitutive photomorphogenesis protein 1 homolog) (mCOP1).

RN123_HUMAN
NC score	0.041733 (rank : 511)	θ value	6.88961 (rank : 447)
Query Neighborhood Hits	471	Target Neighborhood Hits	175	Shared Neighborhood Hits	71
SwissProt Accessions	Q5XPI4, Q5I022, Q6PFW4, Q71RH0, Q8IW18, Q9H0M8, Q9H5L8, Q9H9T2	Gene names	RNF123, KPC1
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase subunit KPC1 (EC 6.3.2.-) (Kip1 ubiquitination-promoting complex protein 1) (RING finger protein 123).

CEND3_MOUSE
NC score	0.036420 (rank : 512)	θ value	6.88961 (rank : 445)
Query Neighborhood Hits	471	Target Neighborhood Hits	228	Shared Neighborhood Hits	28
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

PZRN3_HUMAN
NC score	0.029788 (rank : 513)	θ value	2.36792 (rank : 418)
Query Neighborhood Hits	471	Target Neighborhood Hits	461	Shared Neighborhood Hits	87
SwissProt Accessions	Q9UPQ7, Q8N2N7, Q96CC2, Q9NSQ2	Gene names	PDZRN3, KIAA1095, LNX3, SEMCAP3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Ligand of Numb-protein X 3) (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

PZRN3_MOUSE
NC score	0.029290 (rank : 514)	θ value	3.0926 (rank : 427)
Query Neighborhood Hits	471	Target Neighborhood Hits	447	Shared Neighborhood Hits	88
SwissProt Accessions	Q69ZS0, Q91Z03, Q9QY54, Q9QY55	Gene names	Pdzrn3, Kiaa1095, Semcap3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 3 (Semaphorin cytoplasmic domain-associated protein 3) (SEMACAP3 protein).

PZRN4_HUMAN
NC score	0.026188 (rank : 515)	θ value	8.99809 (rank : 461)
Query Neighborhood Hits	471	Target Neighborhood Hits	438	Shared Neighborhood Hits	83
SwissProt Accessions	Q6ZMN7, Q6N052, Q8IUU1, Q9NTP7	Gene names	PDZRN4, LNX4, SEMCAP3L
Domain Architecture	No domain graphic available
Description	PDZ domain-containing RING finger protein 4 (Ligand of Numb-protein X 4) (SEMACAP3-like protein).

ITB1_HUMAN
NC score	0.021213 (rank : 516)	θ value	3.0926 (rank : 426)
Query Neighborhood Hits	471	Target Neighborhood Hits	298	Shared Neighborhood Hits	15
SwissProt Accessions	P05556, P78466, P78467, Q13089, Q13090, Q13091, Q13212, Q14622, Q14647	Gene names	ITGB1, FNRB
Domain Architecture
Description	Integrin beta-1 precursor (Fibronectin receptor subunit beta) (Integrin VLA-4 subunit beta) (CD29 antigen).

PDZD1_MOUSE
NC score	0.014134 (rank : 517)	θ value	0.163984 (rank : 367)
Query Neighborhood Hits	471	Target Neighborhood Hits	191	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JIL4, Q8CDP5, Q8R4G2, Q9CQ72	Gene names	Pdzk1, Cap70, Nherf3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

MT3_HUMAN
NC score	0.012010 (rank : 518)	θ value	8.99809 (rank : 459)
Query Neighborhood Hits	471	Target Neighborhood Hits	82	Shared Neighborhood Hits	8
SwissProt Accessions	P25713, Q2V574	Gene names	MT3
Domain Architecture	No domain graphic available
Description	Metallothionein-3 (MT-3) (Metallothionein-III) (MT-III) (Growth inhibitory factor) (GIF) (GIFB).

PACN2_HUMAN
NC score	0.011324 (rank : 519)	θ value	8.99809 (rank : 460)
Query Neighborhood Hits	471	Target Neighborhood Hits	339	Shared Neighborhood Hits	19
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

JTB_MOUSE
NC score	0.010259 (rank : 520)	θ value	8.99809 (rank : 457)
Query Neighborhood Hits	471	Target Neighborhood Hits	4	Shared Neighborhood Hits	3
SwissProt Accessions	O88824	Gene names	Jtb
Domain Architecture
Description	Protein JTB precursor.

CCD76_HUMAN
NC score	0.007823 (rank : 521)	θ value	8.99809 (rank : 454)
Query Neighborhood Hits	471	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NUP7, Q5VVL0, Q9NW65	Gene names	CCDC76
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 76.

KRA24_HUMAN
NC score	0.007005 (rank : 522)	θ value	8.99809 (rank : 458)
Query Neighborhood Hits	471	Target Neighborhood Hits	192	Shared Neighborhood Hits	11
SwissProt Accessions	Q9BYR9, Q495J2	Gene names	KRTAP2-4, KAP2.4, KRTAP2.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 2-4 (Keratin-associated protein 2.4) (High sulfur keratin-associated protein 2.4).

PHF14_MOUSE
NC score	0.000609 (rank : 523)	θ value	6.88961 (rank : 446)
Query Neighborhood Hits	471	Target Neighborhood Hits	342	Shared Neighborhood Hits	13
SwissProt Accessions	Q9D4H9, Q810Z6, Q8C284, Q8CGF8, Q9D1Q8	Gene names	Phf14
Domain Architecture
Description	PHD finger protein 14.

TNR23_MOUSE
NC score	-0.001328 (rank : 524)	θ value	8.99809 (rank : 464)
Query Neighborhood Hits	471	Target Neighborhood Hits	114	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ER63, Q8VHC0	Gene names	Tnfrsf23, Dctrailr1, Tnfrh1, Tnfrsf1al1
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 23 precursor (Tumor necrosis factor receptor p60 homolog 1) (TNF receptor family member SOB) (Decoy TRAIL receptor 1) (TNF receptor homolog 1).

FHL1_HUMAN
NC score	-0.001934 (rank : 525)	θ value	3.0926 (rank : 425)
Query Neighborhood Hits	471	Target Neighborhood Hits	436	Shared Neighborhood Hits	5
SwissProt Accessions	Q13642, O95212, Q13230, Q13645, Q5M7Y6, Q9NZ40, Q9UKZ8, Q9Y630	Gene names	FHL1, SLIM1
Domain Architecture
Description	Four and a half LIM domains protein 1 (FHL-1) (Skeletal muscle LIM- protein 1) (SLIM 1) (SLIM).

TR4_MOUSE
NC score	-0.002007 (rank : 526)	θ value	8.99809 (rank : 466)
Query Neighborhood Hits	471	Target Neighborhood Hits	115	Shared Neighborhood Hits	7
SwissProt Accessions	P49117, P55093	Gene names	Nr2c2, Mtr2r1, Tak1, Tr4
Domain Architecture
Description	Orphan nuclear receptor TR4 (Orphan nuclear receptor TAK1).

TR4_HUMAN
NC score	-0.002105 (rank : 527)	θ value	8.99809 (rank : 465)
Query Neighborhood Hits	471	Target Neighborhood Hits	117	Shared Neighborhood Hits	6
SwissProt Accessions	P49116, P55092	Gene names	NR2C2, TAK1, TR4
Domain Architecture
Description	Orphan nuclear receptor TR4 (Orphan nuclear receptor TAK1).

ABCAC_HUMAN
NC score	-0.002124 (rank : 528)	θ value	5.27518 (rank : 439)
Query Neighborhood Hits	471	Target Neighborhood Hits	123	Shared Neighborhood Hits	2
SwissProt Accessions	Q86UK0, Q8IZW6, Q96JT3, Q9Y4M5	Gene names	ABCA12, ABC12
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 12 (ATP-binding cassette transporter 12) (ATP-binding cassette 12).

FHL1_MOUSE
NC score	-0.002357 (rank : 529)	θ value	1.81305 (rank : 415)
Query Neighborhood Hits	471	Target Neighborhood Hits	462	Shared Neighborhood Hits	6
SwissProt Accessions	P97447, O55181, Q8K318	Gene names	Fhl1
Domain Architecture
Description	Four and a half LIM domains protein 1 (FHL-1) (Skeletal muscle LIM- protein 1) (SLIM 1) (SLIM) (KyoT) (RBP-associated molecule 14-1) (RAM14-1).

THA_MOUSE
NC score	-0.003357 (rank : 530)	θ value	8.99809 (rank : 463)
Query Neighborhood Hits	471	Target Neighborhood Hits	113	Shared Neighborhood Hits	5
SwissProt Accessions	P63058, P10685, P15827, P16416, P37241, Q63107, Q63195, Q63196, Q99146	Gene names	Thra, C-erba-alpha, Nr1a1
Domain Architecture	No domain graphic available
Description	Thyroid hormone receptor alpha (C-erbA-alpha) (c-erbA-1).

THA_HUMAN
NC score	-0.003359 (rank : 531)	θ value	8.99809 (rank : 462)
Query Neighborhood Hits	471	Target Neighborhood Hits	113	Shared Neighborhood Hits	5
SwissProt Accessions	P10827, P21205, Q8N6A1, Q96H73	Gene names	THRA, ERBA1, NR1A1, THRA1
Domain Architecture
Description	Thyroid hormone receptor alpha (C-erbA-alpha) (c-erbA-1) (EAR-7) (EAR7).

ARX_HUMAN
NC score	-0.008006 (rank : 532)	θ value	4.03905 (rank : 431)
Query Neighborhood Hits	471	Target Neighborhood Hits	401	Shared Neighborhood Hits	4
SwissProt Accessions	Q96QS3	Gene names	ARX
Domain Architecture
Description	Homeobox protein ARX (Aristaless-related homeobox).

VEZF1_HUMAN
NC score	-0.010987 (rank : 533)	θ value	0.163984 (rank : 371)
Query Neighborhood Hits	471	Target Neighborhood Hits	744	Shared Neighborhood Hits	6
SwissProt Accessions	Q14119	Gene names	VEZF1, DB1, ZNF161
Domain Architecture	No domain graphic available
Description	Vascular endothelial zinc finger 1 (Zinc finger protein 161) (Putative transcription factor DB1).

PAR1_HUMAN
NC score	-0.011932 (rank : 534)	θ value	4.03905 (rank : 432)
Query Neighborhood Hits	471	Target Neighborhood Hits	654	Shared Neighborhood Hits	2
SwissProt Accessions	P25116, Q96RF7, Q9BUN4	Gene names	F2R, CF2R, PAR1, TR
Domain Architecture
Description	Proteinase-activated receptor 1 precursor (PAR-1) (Thrombin receptor) (Coagulation factor II receptor).

MTF1_HUMAN
NC score	-0.012889 (rank : 535)	θ value	1.38821 (rank : 406)
Query Neighborhood Hits	471	Target Neighborhood Hits	814	Shared Neighborhood Hits	8
SwissProt Accessions	Q14872, Q96CB1	Gene names	MTF1
Domain Architecture	No domain graphic available
Description	Metal-regulatory transcription factor 1 (Transcription factor MTF-1) (MRE-binding transcription factor).

ZN319_HUMAN
NC score	-0.013745 (rank : 536)	θ value	6.88961 (rank : 451)
Query Neighborhood Hits	471	Target Neighborhood Hits	772	Shared Neighborhood Hits	17
SwissProt Accessions	Q9P2F9	Gene names	ZNF319, KIAA1388
Domain Architecture	No domain graphic available
Description	Zinc finger protein 319.

ZN319_MOUSE
NC score	-0.013856 (rank : 537)	θ value	6.88961 (rank : 452)
Query Neighborhood Hits	471	Target Neighborhood Hits	762	Shared Neighborhood Hits	14
SwissProt Accessions	Q9ERR8	Gene names	Znf319, Zfp319
Domain Architecture	No domain graphic available
Description	Zinc finger protein 319.