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Network neighborhood for query Sequence : DOCK9_HUMAN

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DOCK9_HUMAN
SwissProt Accessions	Q9BZ29, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4	Gene names	DOCK9, KIAA1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DOC10_HUMAN
θ value	0 (rank : 1)	NC score	0.977872 (rank : 3)
Query Neighborhood Hits	82	Target Neighborhood Hits	88	Shared Neighborhood Hits	33
SwissProt Accessions	Q96BY6, O75178, Q9NW06, Q9NXI8	Gene names	DOCK10, KIAA0694
Domain Architecture
Description	Dedicator of cytokinesis protein 10 (Protein zizimin 3).

DOCK6_HUMAN
θ value	0 (rank : 2)	NC score	0.924088 (rank : 4)
Query Neighborhood Hits	82	Target Neighborhood Hits	71	Shared Neighborhood Hits	14
SwissProt Accessions	Q96HP0, Q9P2F2	Gene names	DOCK6, KIAA1395
Domain Architecture
Description	Dedicator of cytokinesis protein 6.

DOCK9_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	82	Target Neighborhood Hits	82	Shared Neighborhood Hits	82
SwissProt Accessions	Q9BZ29, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4	Gene names	DOCK9, KIAA1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

DOCK9_MOUSE
θ value	0 (rank : 4)	NC score	0.996438 (rank : 2)
Query Neighborhood Hits	82	Target Neighborhood Hits	79	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BIK4, Q921Y6	Gene names	Dock9, D14Wsu89e, Kiaa1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

DOCK7_HUMAN
θ value	3.1544e-162 (rank : 5)	NC score	0.917875 (rank : 5)
Query Neighborhood Hits	82	Target Neighborhood Hits	29	Shared Neighborhood Hits	14
SwissProt Accessions	Q96N67, Q6ZV32, Q8TB82, Q96NG6, Q9C092	Gene names	DOCK7, KIAA1771
Domain Architecture	No domain graphic available
Description	Dedicator of cytokinesis protein 7.

DOCK8_HUMAN
θ value	4.13891e-146 (rank : 6)	NC score	0.905103 (rank : 7)
Query Neighborhood Hits	82	Target Neighborhood Hits	42	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NF50, Q3MV16, Q5JPJ1, Q8TEP1, Q8WUY2, Q9BYJ5, Q9H1Q2, Q9H1Q3, Q9H308, Q9H7P2	Gene names	DOCK8
Domain Architecture	No domain graphic available
Description	Dedicator of cytokinesis protein 8.

DOCK8_MOUSE
θ value	5.99046e-137 (rank : 7)	NC score	0.915116 (rank : 6)
Query Neighborhood Hits	82	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	Q8C147, Q6PIS0, Q7TMQ5, Q8K105, Q9DBQ2	Gene names	Dock8
Domain Architecture	No domain graphic available
Description	Dedicator of cytokinesis protein 8.

DOCK3_HUMAN
θ value	1.80466e-16 (rank : 8)	NC score	0.452725 (rank : 8)
Query Neighborhood Hits	82	Target Neighborhood Hits	87	Shared Neighborhood Hits	15
SwissProt Accessions	Q8IZD9, O15017	Gene names	DOCK3, KIAA0299, MOCA
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

DOCK3_MOUSE
θ value	4.02038e-16 (rank : 9)	NC score	0.452084 (rank : 9)
Query Neighborhood Hits	82	Target Neighborhood Hits	93	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CIQ7	Gene names	Dock3, Moca
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

DOCK4_HUMAN
θ value	1.74796e-11 (rank : 10)	NC score	0.415623 (rank : 10)
Query Neighborhood Hits	82	Target Neighborhood Hits	237	Shared Neighborhood Hits	15
SwissProt Accessions	Q8N1I0, O14584, O94824, Q8NB45	Gene names	DOCK4, KIAA0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

DOCK4_MOUSE
θ value	2.28291e-11 (rank : 11)	NC score	0.414501 (rank : 11)
Query Neighborhood Hits	82	Target Neighborhood Hits	210	Shared Neighborhood Hits	14
SwissProt Accessions	P59764	Gene names	Dock4, Kiaa0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

DOCK2_MOUSE
θ value	3.89403e-11 (rank : 12)	NC score	0.404548 (rank : 13)
Query Neighborhood Hits	82	Target Neighborhood Hits	104	Shared Neighborhood Hits	17
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

DOCK2_HUMAN
θ value	1.47974e-10 (rank : 13)	NC score	0.405538 (rank : 12)
Query Neighborhood Hits	82	Target Neighborhood Hits	90	Shared Neighborhood Hits	18
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

DOCK1_HUMAN
θ value	1.9326e-10 (rank : 14)	NC score	0.392638 (rank : 14)
Query Neighborhood Hits	82	Target Neighborhood Hits	191	Shared Neighborhood Hits	16
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

RHG25_HUMAN
θ value	0.000121331 (rank : 15)	NC score	0.116326 (rank : 17)
Query Neighborhood Hits	82	Target Neighborhood Hits	550	Shared Neighborhood Hits	38
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_MOUSE
θ value	0.00035302 (rank : 16)	NC score	0.106895 (rank : 19)
Query Neighborhood Hits	82	Target Neighborhood Hits	492	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

PKHA6_MOUSE
θ value	0.000461057 (rank : 17)	NC score	0.118261 (rank : 15)
Query Neighborhood Hits	82	Target Neighborhood Hits	591	Shared Neighborhood Hits	42
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

CENB2_HUMAN
θ value	0.00134147 (rank : 18)	NC score	0.056782 (rank : 35)
Query Neighborhood Hits	82	Target Neighborhood Hits	425	Shared Neighborhood Hits	26
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

IRS1_HUMAN
θ value	0.00390308 (rank : 19)	NC score	0.092135 (rank : 24)
Query Neighborhood Hits	82	Target Neighborhood Hits	109	Shared Neighborhood Hits	11
SwissProt Accessions	P35568	Gene names	IRS1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

IRS1_MOUSE
θ value	0.00390308 (rank : 20)	NC score	0.090815 (rank : 25)
Query Neighborhood Hits	82	Target Neighborhood Hits	112	Shared Neighborhood Hits	10
SwissProt Accessions	P35569	Gene names	Irs1, Irs-1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

PKHA5_HUMAN
θ value	0.00509761 (rank : 21)	NC score	0.108253 (rank : 18)
Query Neighborhood Hits	82	Target Neighborhood Hits	455	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

CENB1_HUMAN
θ value	0.0113563 (rank : 22)	NC score	0.056409 (rank : 36)
Query Neighborhood Hits	82	Target Neighborhood Hits	383	Shared Neighborhood Hits	23
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

GAB2_HUMAN
θ value	0.0148317 (rank : 23)	NC score	0.116513 (rank : 16)
Query Neighborhood Hits	82	Target Neighborhood Hits	188	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

SPTN2_HUMAN
θ value	0.0193708 (rank : 24)	NC score	0.048634 (rank : 39)
Query Neighborhood Hits	82	Target Neighborhood Hits	535	Shared Neighborhood Hits	27
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

DAPP1_HUMAN
θ value	0.0563607 (rank : 25)	NC score	0.072042 (rank : 30)
Query Neighborhood Hits	82	Target Neighborhood Hits	227	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	0.0563607 (rank : 26)	NC score	0.072392 (rank : 28)
Query Neighborhood Hits	82	Target Neighborhood Hits	225	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

GAB1_HUMAN
θ value	0.0961366 (rank : 27)	NC score	0.082274 (rank : 27)
Query Neighborhood Hits	82	Target Neighborhood Hits	279	Shared Neighborhood Hits	21
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

OSBP1_HUMAN
θ value	0.0961366 (rank : 28)	NC score	0.049339 (rank : 38)
Query Neighborhood Hits	82	Target Neighborhood Hits	180	Shared Neighborhood Hits	24
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

PKHA4_MOUSE
θ value	0.125558 (rank : 29)	NC score	0.106346 (rank : 20)
Query Neighborhood Hits	82	Target Neighborhood Hits	202	Shared Neighborhood Hits	26
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_HUMAN
θ value	0.163984 (rank : 30)	NC score	0.102197 (rank : 22)
Query Neighborhood Hits	82	Target Neighborhood Hits	283	Shared Neighborhood Hits	30
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

CENPF_HUMAN
θ value	0.21417 (rank : 31)	NC score	0.021349 (rank : 54)
Query Neighborhood Hits	82	Target Neighborhood Hits	1932	Shared Neighborhood Hits	30
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

GAB1_MOUSE
θ value	0.21417 (rank : 32)	NC score	0.099614 (rank : 23)
Query Neighborhood Hits	82	Target Neighborhood Hits	233	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

SPTB2_HUMAN
θ value	0.21417 (rank : 33)	NC score	0.037079 (rank : 40)
Query Neighborhood Hits	82	Target Neighborhood Hits	748	Shared Neighborhood Hits	25
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTB2_MOUSE
θ value	0.21417 (rank : 34)	NC score	0.036117 (rank : 42)
Query Neighborhood Hits	82	Target Neighborhood Hits	770	Shared Neighborhood Hits	25
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

PLEK_HUMAN
θ value	0.47712 (rank : 35)	NC score	0.086032 (rank : 26)
Query Neighborhood Hits	82	Target Neighborhood Hits	110	Shared Neighborhood Hits	26
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

UACA_HUMAN
θ value	0.47712 (rank : 36)	NC score	0.018164 (rank : 59)
Query Neighborhood Hits	82	Target Neighborhood Hits	1622	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

DSPP_HUMAN
θ value	0.62314 (rank : 37)	NC score	0.022644 (rank : 52)
Query Neighborhood Hits	82	Target Neighborhood Hits	645	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

PLK4_MOUSE
θ value	0.62314 (rank : 38)	NC score	0.001055 (rank : 84)
Query Neighborhood Hits	82	Target Neighborhood Hits	879	Shared Neighborhood Hits	6
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

SPTN4_HUMAN
θ value	0.62314 (rank : 39)	NC score	0.036541 (rank : 41)
Query Neighborhood Hits	82	Target Neighborhood Hits	570	Shared Neighborhood Hits	26
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

DYR1A_HUMAN
θ value	0.813845 (rank : 40)	NC score	0.006790 (rank : 79)
Query Neighborhood Hits	82	Target Neighborhood Hits	764	Shared Neighborhood Hits	7
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

OSBP2_HUMAN
θ value	0.813845 (rank : 41)	NC score	0.032915 (rank : 43)
Query Neighborhood Hits	82	Target Neighborhood Hits	154	Shared Neighborhood Hits	18
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

FSBP_MOUSE
θ value	1.06291 (rank : 42)	NC score	0.027506 (rank : 46)
Query Neighborhood Hits	82	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BKE5, Q8BJX8	Gene names	Fsbp
Domain Architecture	No domain graphic available
Description	Fibrinogen silencer-binding protein.

MYH14_MOUSE
θ value	1.06291 (rank : 43)	NC score	0.011603 (rank : 69)
Query Neighborhood Hits	82	Target Neighborhood Hits	1225	Shared Neighborhood Hits	25
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

OSBP2_MOUSE
θ value	1.06291 (rank : 44)	NC score	0.032686 (rank : 44)
Query Neighborhood Hits	82	Target Neighborhood Hits	150	Shared Neighborhood Hits	19
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

PLEK_MOUSE
θ value	1.38821 (rank : 45)	NC score	0.072151 (rank : 29)
Query Neighborhood Hits	82	Target Neighborhood Hits	109	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

DMD_HUMAN
θ value	1.81305 (rank : 46)	NC score	0.021632 (rank : 53)
Query Neighborhood Hits	82	Target Neighborhood Hits	1135	Shared Neighborhood Hits	23
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

K0319_HUMAN
θ value	1.81305 (rank : 47)	NC score	0.023121 (rank : 50)
Query Neighborhood Hits	82	Target Neighborhood Hits	154	Shared Neighborhood Hits	3
SwissProt Accessions	Q5VV43, Q9UJC8, Q9Y4G7	Gene names	KIAA0319
Domain Architecture	No domain graphic available
Description	Protein KIAA0319 precursor.

NOC3L_HUMAN
θ value	2.36792 (rank : 48)	NC score	0.026463 (rank : 48)
Query Neighborhood Hits	82	Target Neighborhood Hits	135	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WTT2, Q9H5M6, Q9H9D8	Gene names	NOC3L, AD24, C10orf117, FAD24
Domain Architecture	No domain graphic available
Description	Nucleolar complex protein 3 homolog (NOC3 protein homolog) (NOC3-like protein) (Nucleolar complex-associated protein 3-like protein) (Factor for adipocyte differentiation 24).

PLEK2_HUMAN
θ value	2.36792 (rank : 49)	NC score	0.070741 (rank : 32)
Query Neighborhood Hits	82	Target Neighborhood Hits	101	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

ANR26_HUMAN
θ value	3.0926 (rank : 50)	NC score	0.009903 (rank : 73)
Query Neighborhood Hits	82	Target Neighborhood Hits	1614	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

DYR1A_MOUSE
θ value	3.0926 (rank : 51)	NC score	0.003611 (rank : 83)
Query Neighborhood Hits	82	Target Neighborhood Hits	762	Shared Neighborhood Hits	6
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

GBP1_MOUSE
θ value	3.0926 (rank : 52)	NC score	0.010399 (rank : 72)
Query Neighborhood Hits	82	Target Neighborhood Hits	302	Shared Neighborhood Hits	11
SwissProt Accessions	Q01514	Gene names	Gbp1, Gbp-1, Mag-1, Mpa1
Domain Architecture
Description	Interferon-induced guanylate-binding protein 1 (GTP-binding protein 1) (Guanine nucleotide-binding protein 1) (GBP-1) (mGBP1) (mGBP-1) (Interferon-gamma-inducible protein MAG-1).

GOGB1_HUMAN
θ value	3.0926 (rank : 53)	NC score	0.019594 (rank : 56)
Query Neighborhood Hits	82	Target Neighborhood Hits	2297	Shared Neighborhood Hits	32
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

HD_HUMAN
θ value	3.0926 (rank : 54)	NC score	0.024406 (rank : 49)
Query Neighborhood Hits	82	Target Neighborhood Hits	165	Shared Neighborhood Hits	5
SwissProt Accessions	P42858, Q9UQB7	Gene names	HD, IT15
Domain Architecture
Description	Huntingtin (Huntington disease protein) (HD protein).

AHI1_MOUSE
θ value	4.03905 (rank : 55)	NC score	0.009149 (rank : 74)
Query Neighborhood Hits	82	Target Neighborhood Hits	496	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

CEND2_HUMAN
θ value	4.03905 (rank : 56)	NC score	0.027496 (rank : 47)
Query Neighborhood Hits	82	Target Neighborhood Hits	166	Shared Neighborhood Hits	21
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

CT112_MOUSE
θ value	4.03905 (rank : 57)	NC score	0.020600 (rank : 55)
Query Neighborhood Hits	82	Target Neighborhood Hits	35	Shared Neighborhood Hits	6
SwissProt Accessions	Q6DIB4	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf112 homolog.

CYTSA_HUMAN
θ value	4.03905 (rank : 58)	NC score	0.016804 (rank : 62)
Query Neighborhood Hits	82	Target Neighborhood Hits	1138	Shared Neighborhood Hits	24
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

CYTSA_MOUSE
θ value	4.03905 (rank : 59)	NC score	0.016832 (rank : 61)
Query Neighborhood Hits	82	Target Neighborhood Hits	1104	Shared Neighborhood Hits	25
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

FGD5_HUMAN
θ value	4.03905 (rank : 60)	NC score	0.014626 (rank : 64)
Query Neighborhood Hits	82	Target Neighborhood Hits	235	Shared Neighborhood Hits	13
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

K0226_HUMAN
θ value	4.03905 (rank : 61)	NC score	0.022883 (rank : 51)
Query Neighborhood Hits	82	Target Neighborhood Hits	92	Shared Neighborhood Hits	3
SwissProt Accessions	Q92622	Gene names	KIAA0226
Domain Architecture	No domain graphic available
Description	Protein KIAA0226.

PLCG1_MOUSE
θ value	4.03905 (rank : 62)	NC score	0.018905 (rank : 57)
Query Neighborhood Hits	82	Target Neighborhood Hits	314	Shared Neighborhood Hits	10
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

RPGF6_HUMAN
θ value	4.03905 (rank : 63)	NC score	0.007447 (rank : 78)
Query Neighborhood Hits	82	Target Neighborhood Hits	266	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

TTC3_HUMAN
θ value	4.03905 (rank : 64)	NC score	0.017321 (rank : 60)
Query Neighborhood Hits	82	Target Neighborhood Hits	664	Shared Neighborhood Hits	19
SwissProt Accessions	P53804, O60767, P78476, P78477	Gene names	TTC3, TPRD
Domain Architecture
Description	Tetratricopeptide repeat protein 3 (TPR repeat protein 3) (TPR repeat protein D).

UBN1_HUMAN
θ value	4.03905 (rank : 65)	NC score	0.028223 (rank : 45)
Query Neighborhood Hits	82	Target Neighborhood Hits	170	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NPG3, Q13079, Q9P1P7	Gene names	UBN1
Domain Architecture	No domain graphic available
Description	Ubinuclein (Ubiquitously expressed nuclear protein) (VT4).

DSPP_MOUSE
θ value	5.27518 (rank : 66)	NC score	0.012510 (rank : 68)
Query Neighborhood Hits	82	Target Neighborhood Hits	491	Shared Neighborhood Hits	8
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

MACF1_MOUSE
θ value	5.27518 (rank : 67)	NC score	0.018220 (rank : 58)
Query Neighborhood Hits	82	Target Neighborhood Hits	1313	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

PKHA1_HUMAN
θ value	5.27518 (rank : 68)	NC score	0.065355 (rank : 33)
Query Neighborhood Hits	82	Target Neighborhood Hits	127	Shared Neighborhood Hits	28
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

TRIPB_HUMAN
θ value	5.27518 (rank : 69)	NC score	0.014735 (rank : 63)
Query Neighborhood Hits	82	Target Neighborhood Hits	1587	Shared Neighborhood Hits	29
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

ANK2_HUMAN
θ value	6.88961 (rank : 70)	NC score	0.007482 (rank : 77)
Query Neighborhood Hits	82	Target Neighborhood Hits	1615	Shared Neighborhood Hits	27
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

CHSTB_MOUSE
θ value	6.88961 (rank : 71)	NC score	0.013558 (rank : 65)
Query Neighborhood Hits	82	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JME2, Q9JJS2	Gene names	Chst11
Domain Architecture	No domain graphic available
Description	Carbohydrate sulfotransferase 11 (EC 2.8.2.5) (Chondroitin 4-O- sulfotransferase 1) (Chondroitin 4-sulfotransferase 1) (C4ST) (C4ST-1) (C4S-1).

CTRO_MOUSE
θ value	6.88961 (rank : 72)	NC score	0.005269 (rank : 81)
Query Neighborhood Hits	82	Target Neighborhood Hits	2344	Shared Neighborhood Hits	32
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

DPOE3_MOUSE
θ value	6.88961 (rank : 73)	NC score	0.013248 (rank : 67)
Query Neighborhood Hits	82	Target Neighborhood Hits	51	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JKP7, Q8R198	Gene names	Pole3
Domain Architecture
Description	DNA polymerase epsilon subunit 3 (EC 2.7.7.7) (DNA polymerase II subunit 3) (DNA polymerase epsilon subunit p17) (YB-like protein 1) (YBL1) (NF-YB-like protein).

NFM_MOUSE
θ value	6.88961 (rank : 74)	NC score	0.004121 (rank : 82)
Query Neighborhood Hits	82	Target Neighborhood Hits	1159	Shared Neighborhood Hits	22
SwissProt Accessions	P08553, Q61961	Gene names	Nef3, Nefm, Nfm
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M).

OCTC_MOUSE
θ value	6.88961 (rank : 75)	NC score	0.005605 (rank : 80)
Query Neighborhood Hits	82	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	Q9DC50, Q921I4	Gene names	Crot, Cot
Domain Architecture
Description	Peroxisomal carnitine O-octanoyltransferase (EC 2.3.1.137) (COT).

PLEK2_MOUSE
θ value	6.88961 (rank : 76)	NC score	0.061942 (rank : 34)
Query Neighborhood Hits	82	Target Neighborhood Hits	96	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

BACH_HUMAN
θ value	8.99809 (rank : 77)	NC score	0.013290 (rank : 66)
Query Neighborhood Hits	82	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	O00154, O43703, Q5JYL4, Q9UJM9, Q9Y539, Q9Y540	Gene names	ACOT7, BACH
Domain Architecture
Description	Cytosolic acyl coenzyme A thioester hydrolase (EC 3.1.2.2) (Long chain acyl-CoA thioester hydrolase) (CTE-II) (CTE-IIa) (Brain acyl-CoA hydrolase) (Acyl-CoA thioesterase 7).

DESP_HUMAN
θ value	8.99809 (rank : 78)	NC score	0.010731 (rank : 71)
Query Neighborhood Hits	82	Target Neighborhood Hits	1470	Shared Neighborhood Hits	27
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

GOGA4_MOUSE
θ value	8.99809 (rank : 79)	NC score	0.011025 (rank : 70)
Query Neighborhood Hits	82	Target Neighborhood Hits	1939	Shared Neighborhood Hits	31
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

LGP2_HUMAN
θ value	8.99809 (rank : 80)	NC score	0.008011 (rank : 75)
Query Neighborhood Hits	82	Target Neighborhood Hits	94	Shared Neighborhood Hits	3
SwissProt Accessions	Q96C10, Q9HAM6	Gene names	LGP2, D11LGP2E
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2 homolog).

PRP4B_MOUSE
θ value	8.99809 (rank : 81)	NC score	0.000870 (rank : 85)
Query Neighborhood Hits	82	Target Neighborhood Hits	1040	Shared Neighborhood Hits	10
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).

PUR2_MOUSE
θ value	8.99809 (rank : 82)	NC score	0.007807 (rank : 76)
Query Neighborhood Hits	82	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q64737, Q6NS48	Gene names	Gart
Domain Architecture
Description	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)].

GAB2_MOUSE
θ value	θ > 10 (rank : 83)	NC score	0.103828 (rank : 21)
Query Neighborhood Hits	82	Target Neighborhood Hits	220	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

PKHA1_MOUSE
θ value	θ > 10 (rank : 84)	NC score	0.054163 (rank : 37)
Query Neighborhood Hits	82	Target Neighborhood Hits	120	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA6_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.071066 (rank : 31)
Query Neighborhood Hits	82	Target Neighborhood Hits	556	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

Hits sorted by NC score

DOCK9_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	82	Target Neighborhood Hits	82	Shared Neighborhood Hits	82
SwissProt Accessions	Q9BZ29, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4	Gene names	DOCK9, KIAA1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

DOCK9_MOUSE
NC score	0.996438 (rank : 2)	θ value	0 (rank : 4)
Query Neighborhood Hits	82	Target Neighborhood Hits	79	Shared Neighborhood Hits	61
SwissProt Accessions	Q8BIK4, Q921Y6	Gene names	Dock9, D14Wsu89e, Kiaa1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

DOC10_HUMAN
NC score	0.977872 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	82	Target Neighborhood Hits	88	Shared Neighborhood Hits	33
SwissProt Accessions	Q96BY6, O75178, Q9NW06, Q9NXI8	Gene names	DOCK10, KIAA0694
Domain Architecture
Description	Dedicator of cytokinesis protein 10 (Protein zizimin 3).

DOCK6_HUMAN
NC score	0.924088 (rank : 4)	θ value	0 (rank : 2)
Query Neighborhood Hits	82	Target Neighborhood Hits	71	Shared Neighborhood Hits	14
SwissProt Accessions	Q96HP0, Q9P2F2	Gene names	DOCK6, KIAA1395
Domain Architecture
Description	Dedicator of cytokinesis protein 6.

DOCK7_HUMAN
NC score	0.917875 (rank : 5)	θ value	3.1544e-162 (rank : 5)
Query Neighborhood Hits	82	Target Neighborhood Hits	29	Shared Neighborhood Hits	14
SwissProt Accessions	Q96N67, Q6ZV32, Q8TB82, Q96NG6, Q9C092	Gene names	DOCK7, KIAA1771
Domain Architecture	No domain graphic available
Description	Dedicator of cytokinesis protein 7.

DOCK8_MOUSE
NC score	0.915116 (rank : 6)	θ value	5.99046e-137 (rank : 7)
Query Neighborhood Hits	82	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	Q8C147, Q6PIS0, Q7TMQ5, Q8K105, Q9DBQ2	Gene names	Dock8
Domain Architecture	No domain graphic available
Description	Dedicator of cytokinesis protein 8.

DOCK8_HUMAN
NC score	0.905103 (rank : 7)	θ value	4.13891e-146 (rank : 6)
Query Neighborhood Hits	82	Target Neighborhood Hits	42	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NF50, Q3MV16, Q5JPJ1, Q8TEP1, Q8WUY2, Q9BYJ5, Q9H1Q2, Q9H1Q3, Q9H308, Q9H7P2	Gene names	DOCK8
Domain Architecture	No domain graphic available
Description	Dedicator of cytokinesis protein 8.

DOCK3_HUMAN
NC score	0.452725 (rank : 8)	θ value	1.80466e-16 (rank : 8)
Query Neighborhood Hits	82	Target Neighborhood Hits	87	Shared Neighborhood Hits	15
SwissProt Accessions	Q8IZD9, O15017	Gene names	DOCK3, KIAA0299, MOCA
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

DOCK3_MOUSE
NC score	0.452084 (rank : 9)	θ value	4.02038e-16 (rank : 9)
Query Neighborhood Hits	82	Target Neighborhood Hits	93	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CIQ7	Gene names	Dock3, Moca
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

DOCK4_HUMAN
NC score	0.415623 (rank : 10)	θ value	1.74796e-11 (rank : 10)
Query Neighborhood Hits	82	Target Neighborhood Hits	237	Shared Neighborhood Hits	15
SwissProt Accessions	Q8N1I0, O14584, O94824, Q8NB45	Gene names	DOCK4, KIAA0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

DOCK4_MOUSE
NC score	0.414501 (rank : 11)	θ value	2.28291e-11 (rank : 11)
Query Neighborhood Hits	82	Target Neighborhood Hits	210	Shared Neighborhood Hits	14
SwissProt Accessions	P59764	Gene names	Dock4, Kiaa0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

DOCK2_HUMAN
NC score	0.405538 (rank : 12)	θ value	1.47974e-10 (rank : 13)
Query Neighborhood Hits	82	Target Neighborhood Hits	90	Shared Neighborhood Hits	18
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

DOCK2_MOUSE
NC score	0.404548 (rank : 13)	θ value	3.89403e-11 (rank : 12)
Query Neighborhood Hits	82	Target Neighborhood Hits	104	Shared Neighborhood Hits	17
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

DOCK1_HUMAN
NC score	0.392638 (rank : 14)	θ value	1.9326e-10 (rank : 14)
Query Neighborhood Hits	82	Target Neighborhood Hits	191	Shared Neighborhood Hits	16
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

PKHA6_MOUSE
NC score	0.118261 (rank : 15)	θ value	0.000461057 (rank : 17)
Query Neighborhood Hits	82	Target Neighborhood Hits	591	Shared Neighborhood Hits	42
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

GAB2_HUMAN
NC score	0.116513 (rank : 16)	θ value	0.0148317 (rank : 23)
Query Neighborhood Hits	82	Target Neighborhood Hits	188	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

RHG25_HUMAN
NC score	0.116326 (rank : 17)	θ value	0.000121331 (rank : 15)
Query Neighborhood Hits	82	Target Neighborhood Hits	550	Shared Neighborhood Hits	38
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

PKHA5_HUMAN
NC score	0.108253 (rank : 18)	θ value	0.00509761 (rank : 21)
Query Neighborhood Hits	82	Target Neighborhood Hits	455	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

RHG25_MOUSE
NC score	0.106895 (rank : 19)	θ value	0.00035302 (rank : 16)
Query Neighborhood Hits	82	Target Neighborhood Hits	492	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

PKHA4_MOUSE
NC score	0.106346 (rank : 20)	θ value	0.125558 (rank : 29)
Query Neighborhood Hits	82	Target Neighborhood Hits	202	Shared Neighborhood Hits	26
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

GAB2_MOUSE
NC score	0.103828 (rank : 21)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	82	Target Neighborhood Hits	220	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

PKHA4_HUMAN
NC score	0.102197 (rank : 22)	θ value	0.163984 (rank : 30)
Query Neighborhood Hits	82	Target Neighborhood Hits	283	Shared Neighborhood Hits	30
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

GAB1_MOUSE
NC score	0.099614 (rank : 23)	θ value	0.21417 (rank : 32)
Query Neighborhood Hits	82	Target Neighborhood Hits	233	Shared Neighborhood Hits	22
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

IRS1_HUMAN
NC score	0.092135 (rank : 24)	θ value	0.00390308 (rank : 19)
Query Neighborhood Hits	82	Target Neighborhood Hits	109	Shared Neighborhood Hits	11
SwissProt Accessions	P35568	Gene names	IRS1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

IRS1_MOUSE
NC score	0.090815 (rank : 25)	θ value	0.00390308 (rank : 20)
Query Neighborhood Hits	82	Target Neighborhood Hits	112	Shared Neighborhood Hits	10
SwissProt Accessions	P35569	Gene names	Irs1, Irs-1
Domain Architecture
Description	Insulin receptor substrate 1 (IRS-1).

PLEK_HUMAN
NC score	0.086032 (rank : 26)	θ value	0.47712 (rank : 35)
Query Neighborhood Hits	82	Target Neighborhood Hits	110	Shared Neighborhood Hits	26
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

GAB1_HUMAN
NC score	0.082274 (rank : 27)	θ value	0.0961366 (rank : 27)
Query Neighborhood Hits	82	Target Neighborhood Hits	279	Shared Neighborhood Hits	21
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

DAPP1_MOUSE
NC score	0.072392 (rank : 28)	θ value	0.0563607 (rank : 26)
Query Neighborhood Hits	82	Target Neighborhood Hits	225	Shared Neighborhood Hits	25
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PLEK_MOUSE
NC score	0.072151 (rank : 29)	θ value	1.38821 (rank : 45)
Query Neighborhood Hits	82	Target Neighborhood Hits	109	Shared Neighborhood Hits	22
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

DAPP1_HUMAN
NC score	0.072042 (rank : 30)	θ value	0.0563607 (rank : 25)
Query Neighborhood Hits	82	Target Neighborhood Hits	227	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PKHA6_HUMAN
NC score	0.071066 (rank : 31)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	82	Target Neighborhood Hits	556	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PLEK2_HUMAN
NC score	0.070741 (rank : 32)	θ value	2.36792 (rank : 49)
Query Neighborhood Hits	82	Target Neighborhood Hits	101	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PKHA1_HUMAN
NC score	0.065355 (rank : 33)	θ value	5.27518 (rank : 68)
Query Neighborhood Hits	82	Target Neighborhood Hits	127	Shared Neighborhood Hits	28
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PLEK2_MOUSE
NC score	0.061942 (rank : 34)	θ value	6.88961 (rank : 76)
Query Neighborhood Hits	82	Target Neighborhood Hits	96	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

CENB2_HUMAN
NC score	0.056782 (rank : 35)	θ value	0.00134147 (rank : 18)
Query Neighborhood Hits	82	Target Neighborhood Hits	425	Shared Neighborhood Hits	26
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENB1_HUMAN
NC score	0.056409 (rank : 36)	θ value	0.0113563 (rank : 22)
Query Neighborhood Hits	82	Target Neighborhood Hits	383	Shared Neighborhood Hits	23
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

PKHA1_MOUSE
NC score	0.054163 (rank : 37)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	82	Target Neighborhood Hits	120	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

OSBP1_HUMAN
NC score	0.049339 (rank : 38)	θ value	0.0961366 (rank : 28)
Query Neighborhood Hits	82	Target Neighborhood Hits	180	Shared Neighborhood Hits	24
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

SPTN2_HUMAN
NC score	0.048634 (rank : 39)	θ value	0.0193708 (rank : 24)
Query Neighborhood Hits	82	Target Neighborhood Hits	535	Shared Neighborhood Hits	27
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

SPTB2_HUMAN
NC score	0.037079 (rank : 40)	θ value	0.21417 (rank : 33)
Query Neighborhood Hits	82	Target Neighborhood Hits	748	Shared Neighborhood Hits	25
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTN4_HUMAN
NC score	0.036541 (rank : 41)	θ value	0.62314 (rank : 39)
Query Neighborhood Hits	82	Target Neighborhood Hits	570	Shared Neighborhood Hits	26
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

SPTB2_MOUSE
NC score	0.036117 (rank : 42)	θ value	0.21417 (rank : 34)
Query Neighborhood Hits	82	Target Neighborhood Hits	770	Shared Neighborhood Hits	25
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

OSBP2_HUMAN
NC score	0.032915 (rank : 43)	θ value	0.813845 (rank : 41)
Query Neighborhood Hits	82	Target Neighborhood Hits	154	Shared Neighborhood Hits	18
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

OSBP2_MOUSE
NC score	0.032686 (rank : 44)	θ value	1.06291 (rank : 44)
Query Neighborhood Hits	82	Target Neighborhood Hits	150	Shared Neighborhood Hits	19
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

UBN1_HUMAN
NC score	0.028223 (rank : 45)	θ value	4.03905 (rank : 65)
Query Neighborhood Hits	82	Target Neighborhood Hits	170	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NPG3, Q13079, Q9P1P7	Gene names	UBN1
Domain Architecture	No domain graphic available
Description	Ubinuclein (Ubiquitously expressed nuclear protein) (VT4).

FSBP_MOUSE
NC score	0.027506 (rank : 46)	θ value	1.06291 (rank : 42)
Query Neighborhood Hits	82	Target Neighborhood Hits	29	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BKE5, Q8BJX8	Gene names	Fsbp
Domain Architecture	No domain graphic available
Description	Fibrinogen silencer-binding protein.

CEND2_HUMAN
NC score	0.027496 (rank : 47)	θ value	4.03905 (rank : 56)
Query Neighborhood Hits	82	Target Neighborhood Hits	166	Shared Neighborhood Hits	21
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

NOC3L_HUMAN
NC score	0.026463 (rank : 48)	θ value	2.36792 (rank : 48)
Query Neighborhood Hits	82	Target Neighborhood Hits	135	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WTT2, Q9H5M6, Q9H9D8	Gene names	NOC3L, AD24, C10orf117, FAD24
Domain Architecture	No domain graphic available
Description	Nucleolar complex protein 3 homolog (NOC3 protein homolog) (NOC3-like protein) (Nucleolar complex-associated protein 3-like protein) (Factor for adipocyte differentiation 24).

HD_HUMAN
NC score	0.024406 (rank : 49)	θ value	3.0926 (rank : 54)
Query Neighborhood Hits	82	Target Neighborhood Hits	165	Shared Neighborhood Hits	5
SwissProt Accessions	P42858, Q9UQB7	Gene names	HD, IT15
Domain Architecture
Description	Huntingtin (Huntington disease protein) (HD protein).

K0319_HUMAN
NC score	0.023121 (rank : 50)	θ value	1.81305 (rank : 47)
Query Neighborhood Hits	82	Target Neighborhood Hits	154	Shared Neighborhood Hits	3
SwissProt Accessions	Q5VV43, Q9UJC8, Q9Y4G7	Gene names	KIAA0319
Domain Architecture	No domain graphic available
Description	Protein KIAA0319 precursor.

K0226_HUMAN
NC score	0.022883 (rank : 51)	θ value	4.03905 (rank : 61)
Query Neighborhood Hits	82	Target Neighborhood Hits	92	Shared Neighborhood Hits	3
SwissProt Accessions	Q92622	Gene names	KIAA0226
Domain Architecture	No domain graphic available
Description	Protein KIAA0226.

DSPP_HUMAN
NC score	0.022644 (rank : 52)	θ value	0.62314 (rank : 37)
Query Neighborhood Hits	82	Target Neighborhood Hits	645	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NZW4, O95815	Gene names	DSPP
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

DMD_HUMAN
NC score	0.021632 (rank : 53)	θ value	1.81305 (rank : 46)
Query Neighborhood Hits	82	Target Neighborhood Hits	1135	Shared Neighborhood Hits	23
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

CENPF_HUMAN
NC score	0.021349 (rank : 54)	θ value	0.21417 (rank : 31)
Query Neighborhood Hits	82	Target Neighborhood Hits	1932	Shared Neighborhood Hits	30
SwissProt Accessions	P49454, Q13171, Q13246	Gene names	CENPF
Domain Architecture
Description	Centromere protein F (Kinetochore protein CENP-F) (Mitosin) (AH antigen).

CT112_MOUSE
NC score	0.020600 (rank : 55)	θ value	4.03905 (rank : 57)
Query Neighborhood Hits	82	Target Neighborhood Hits	35	Shared Neighborhood Hits	6
SwissProt Accessions	Q6DIB4	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf112 homolog.

GOGB1_HUMAN
NC score	0.019594 (rank : 56)	θ value	3.0926 (rank : 53)
Query Neighborhood Hits	82	Target Neighborhood Hits	2297	Shared Neighborhood Hits	32
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

PLCG1_MOUSE
NC score	0.018905 (rank : 57)	θ value	4.03905 (rank : 62)
Query Neighborhood Hits	82	Target Neighborhood Hits	314	Shared Neighborhood Hits	10
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

MACF1_MOUSE
NC score	0.018220 (rank : 58)	θ value	5.27518 (rank : 67)
Query Neighborhood Hits	82	Target Neighborhood Hits	1313	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

UACA_HUMAN
NC score	0.018164 (rank : 59)	θ value	0.47712 (rank : 36)
Query Neighborhood Hits	82	Target Neighborhood Hits	1622	Shared Neighborhood Hits	26
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

TTC3_HUMAN
NC score	0.017321 (rank : 60)	θ value	4.03905 (rank : 64)
Query Neighborhood Hits	82	Target Neighborhood Hits	664	Shared Neighborhood Hits	19
SwissProt Accessions	P53804, O60767, P78476, P78477	Gene names	TTC3, TPRD
Domain Architecture
Description	Tetratricopeptide repeat protein 3 (TPR repeat protein 3) (TPR repeat protein D).

CYTSA_MOUSE
NC score	0.016832 (rank : 61)	θ value	4.03905 (rank : 59)
Query Neighborhood Hits	82	Target Neighborhood Hits	1104	Shared Neighborhood Hits	25
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

CYTSA_HUMAN
NC score	0.016804 (rank : 62)	θ value	4.03905 (rank : 58)
Query Neighborhood Hits	82	Target Neighborhood Hits	1138	Shared Neighborhood Hits	24
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

TRIPB_HUMAN
NC score	0.014735 (rank : 63)	θ value	5.27518 (rank : 69)
Query Neighborhood Hits	82	Target Neighborhood Hits	1587	Shared Neighborhood Hits	29
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

FGD5_HUMAN
NC score	0.014626 (rank : 64)	θ value	4.03905 (rank : 60)
Query Neighborhood Hits	82	Target Neighborhood Hits	235	Shared Neighborhood Hits	13
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

CHSTB_MOUSE
NC score	0.013558 (rank : 65)	θ value	6.88961 (rank : 71)
Query Neighborhood Hits	82	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JME2, Q9JJS2	Gene names	Chst11
Domain Architecture	No domain graphic available
Description	Carbohydrate sulfotransferase 11 (EC 2.8.2.5) (Chondroitin 4-O- sulfotransferase 1) (Chondroitin 4-sulfotransferase 1) (C4ST) (C4ST-1) (C4S-1).

BACH_HUMAN
NC score	0.013290 (rank : 66)	θ value	8.99809 (rank : 77)
Query Neighborhood Hits	82	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	O00154, O43703, Q5JYL4, Q9UJM9, Q9Y539, Q9Y540	Gene names	ACOT7, BACH
Domain Architecture
Description	Cytosolic acyl coenzyme A thioester hydrolase (EC 3.1.2.2) (Long chain acyl-CoA thioester hydrolase) (CTE-II) (CTE-IIa) (Brain acyl-CoA hydrolase) (Acyl-CoA thioesterase 7).

DPOE3_MOUSE
NC score	0.013248 (rank : 67)	θ value	6.88961 (rank : 73)
Query Neighborhood Hits	82	Target Neighborhood Hits	51	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JKP7, Q8R198	Gene names	Pole3
Domain Architecture
Description	DNA polymerase epsilon subunit 3 (EC 2.7.7.7) (DNA polymerase II subunit 3) (DNA polymerase epsilon subunit p17) (YB-like protein 1) (YBL1) (NF-YB-like protein).

DSPP_MOUSE
NC score	0.012510 (rank : 68)	θ value	5.27518 (rank : 66)
Query Neighborhood Hits	82	Target Neighborhood Hits	491	Shared Neighborhood Hits	8
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

MYH14_MOUSE
NC score	0.011603 (rank : 69)	θ value	1.06291 (rank : 43)
Query Neighborhood Hits	82	Target Neighborhood Hits	1225	Shared Neighborhood Hits	25
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

GOGA4_MOUSE
NC score	0.011025 (rank : 70)	θ value	8.99809 (rank : 79)
Query Neighborhood Hits	82	Target Neighborhood Hits	1939	Shared Neighborhood Hits	31
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

DESP_HUMAN
NC score	0.010731 (rank : 71)	θ value	8.99809 (rank : 78)
Query Neighborhood Hits	82	Target Neighborhood Hits	1470	Shared Neighborhood Hits	27
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

GBP1_MOUSE
NC score	0.010399 (rank : 72)	θ value	3.0926 (rank : 52)
Query Neighborhood Hits	82	Target Neighborhood Hits	302	Shared Neighborhood Hits	11
SwissProt Accessions	Q01514	Gene names	Gbp1, Gbp-1, Mag-1, Mpa1
Domain Architecture
Description	Interferon-induced guanylate-binding protein 1 (GTP-binding protein 1) (Guanine nucleotide-binding protein 1) (GBP-1) (mGBP1) (mGBP-1) (Interferon-gamma-inducible protein MAG-1).

ANR26_HUMAN
NC score	0.009903 (rank : 73)	θ value	3.0926 (rank : 50)
Query Neighborhood Hits	82	Target Neighborhood Hits	1614	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

AHI1_MOUSE
NC score	0.009149 (rank : 74)	θ value	4.03905 (rank : 55)
Query Neighborhood Hits	82	Target Neighborhood Hits	496	Shared Neighborhood Hits	8
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

LGP2_HUMAN
NC score	0.008011 (rank : 75)	θ value	8.99809 (rank : 80)
Query Neighborhood Hits	82	Target Neighborhood Hits	94	Shared Neighborhood Hits	3
SwissProt Accessions	Q96C10, Q9HAM6	Gene names	LGP2, D11LGP2E
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent helicase LGP2 (EC 3.6.1.-) (Protein D11Lgp2 homolog).

PUR2_MOUSE
NC score	0.007807 (rank : 76)	θ value	8.99809 (rank : 82)
Query Neighborhood Hits	82	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q64737, Q6NS48	Gene names	Gart
Domain Architecture
Description	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)].

ANK2_HUMAN
NC score	0.007482 (rank : 77)	θ value	6.88961 (rank : 70)
Query Neighborhood Hits	82	Target Neighborhood Hits	1615	Shared Neighborhood Hits	27
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

RPGF6_HUMAN
NC score	0.007447 (rank : 78)	θ value	4.03905 (rank : 63)
Query Neighborhood Hits	82	Target Neighborhood Hits	266	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TEU7, Q8NI21, Q8TEU6, Q96PC1	Gene names	RAPGEF6, PDZGEF2
Domain Architecture
Description	Rap guanine nucleotide exchange factor 6 (PDZ domain-containing guanine nucleotide exchange factor 2) (PDZ-GEF2) (RA-GEF-2).

DYR1A_HUMAN
NC score	0.006790 (rank : 79)	θ value	0.813845 (rank : 40)
Query Neighborhood Hits	82	Target Neighborhood Hits	764	Shared Neighborhood Hits	7
SwissProt Accessions	Q13627, O60769, Q92582, Q92810, Q9UNM5	Gene names	DYRK1A, DYRK, MNB, MNBH
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (HP86) (Dual specificity YAK1-related kinase).

OCTC_MOUSE
NC score	0.005605 (rank : 80)	θ value	6.88961 (rank : 75)
Query Neighborhood Hits	82	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	Q9DC50, Q921I4	Gene names	Crot, Cot
Domain Architecture
Description	Peroxisomal carnitine O-octanoyltransferase (EC 2.3.1.137) (COT).

CTRO_MOUSE
NC score	0.005269 (rank : 81)	θ value	6.88961 (rank : 72)
Query Neighborhood Hits	82	Target Neighborhood Hits	2344	Shared Neighborhood Hits	32
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

NFM_MOUSE
NC score	0.004121 (rank : 82)	θ value	6.88961 (rank : 74)
Query Neighborhood Hits	82	Target Neighborhood Hits	1159	Shared Neighborhood Hits	22
SwissProt Accessions	P08553, Q61961	Gene names	Nef3, Nefm, Nfm
Domain Architecture
Description	Neurofilament triplet M protein (160 kDa neurofilament protein) (Neurofilament medium polypeptide) (NF-M).

DYR1A_MOUSE
NC score	0.003611 (rank : 83)	θ value	3.0926 (rank : 51)
Query Neighborhood Hits	82	Target Neighborhood Hits	762	Shared Neighborhood Hits	6
SwissProt Accessions	Q61214	Gene names	Dyrk1a, Dyrk
Domain Architecture
Description	Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.12.1) (Protein kinase minibrain homolog) (MNBH) (MP86) (Dual specificity YAK1-related kinase).

PLK4_MOUSE
NC score	0.001055 (rank : 84)	θ value	0.62314 (rank : 38)
Query Neighborhood Hits	82	Target Neighborhood Hits	879	Shared Neighborhood Hits	6
SwissProt Accessions	Q64702, Q6PEP6, Q78EG6, Q8R0I5, Q9CVR6, Q9CVU6	Gene names	Plk4, Sak, Stk18
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase PLK4 (EC 2.7.11.21) (Polo-like kinase 4) (PLK-4) (Serine/threonine-protein kinase Sak) (Serine/threonine- protein kinase 18).

PRP4B_MOUSE
NC score	0.000870 (rank : 85)	θ value	8.99809 (rank : 81)
Query Neighborhood Hits	82	Target Neighborhood Hits	1040	Shared Neighborhood Hits	10
SwissProt Accessions	Q61136, O88378, Q8BND8, Q8R4Y5, Q9CTL9, Q9CTT0	Gene names	Prpf4b, Cbp143, Prp4h, Prp4k, Prp4m, Prpk
Domain Architecture
Description	Serine/threonine-protein kinase PRP4 homolog (EC 2.7.11.1) (PRP4 pre- mRNA-processing factor 4 homolog) (Pre-mRNA protein kinase).