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Network neighborhood for query Sequence : DOCK2_HUMAN

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DOCK2_HUMAN
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DOCK1_HUMAN
θ value	0 (rank : 1)	NC score	0.968881 (rank : 3)
Query Neighborhood Hits	90	Target Neighborhood Hits	191	Shared Neighborhood Hits	54
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

DOCK2_HUMAN
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	90	Target Neighborhood Hits	90	Shared Neighborhood Hits	90
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

DOCK2_MOUSE
θ value	0 (rank : 3)	NC score	0.995549 (rank : 2)
Query Neighborhood Hits	90	Target Neighborhood Hits	104	Shared Neighborhood Hits	65
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

DOCK3_HUMAN
θ value	0 (rank : 4)	NC score	0.967079 (rank : 4)
Query Neighborhood Hits	90	Target Neighborhood Hits	87	Shared Neighborhood Hits	29
SwissProt Accessions	Q8IZD9, O15017	Gene names	DOCK3, KIAA0299, MOCA
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

DOCK3_MOUSE
θ value	0 (rank : 5)	NC score	0.966041 (rank : 5)
Query Neighborhood Hits	90	Target Neighborhood Hits	93	Shared Neighborhood Hits	28
SwissProt Accessions	Q8CIQ7	Gene names	Dock3, Moca
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

DOCK4_HUMAN
θ value	0 (rank : 6)	NC score	0.955163 (rank : 7)
Query Neighborhood Hits	90	Target Neighborhood Hits	237	Shared Neighborhood Hits	27
SwissProt Accessions	Q8N1I0, O14584, O94824, Q8NB45	Gene names	DOCK4, KIAA0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

DOCK4_MOUSE
θ value	0 (rank : 7)	NC score	0.955973 (rank : 6)
Query Neighborhood Hits	90	Target Neighborhood Hits	210	Shared Neighborhood Hits	28
SwissProt Accessions	P59764	Gene names	Dock4, Kiaa0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

DOC10_HUMAN
θ value	1.52774e-15 (rank : 8)	NC score	0.449803 (rank : 8)
Query Neighborhood Hits	90	Target Neighborhood Hits	88	Shared Neighborhood Hits	14
SwissProt Accessions	Q96BY6, O75178, Q9NW06, Q9NXI8	Gene names	DOCK10, KIAA0694
Domain Architecture
Description	Dedicator of cytokinesis protein 10 (Protein zizimin 3).

DOCK9_HUMAN
θ value	1.47974e-10 (rank : 9)	NC score	0.405538 (rank : 10)
Query Neighborhood Hits	90	Target Neighborhood Hits	82	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BZ29, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4	Gene names	DOCK9, KIAA1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

DOCK9_MOUSE
θ value	2.52405e-10 (rank : 10)	NC score	0.407731 (rank : 9)
Query Neighborhood Hits	90	Target Neighborhood Hits	79	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BIK4, Q921Y6	Gene names	Dock9, D14Wsu89e, Kiaa1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

DOCK8_HUMAN
θ value	5.62301e-10 (rank : 11)	NC score	0.395061 (rank : 12)
Query Neighborhood Hits	90	Target Neighborhood Hits	42	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NF50, Q3MV16, Q5JPJ1, Q8TEP1, Q8WUY2, Q9BYJ5, Q9H1Q2, Q9H1Q3, Q9H308, Q9H7P2	Gene names	DOCK8
Domain Architecture	No domain graphic available
Description	Dedicator of cytokinesis protein 8.

DOCK6_HUMAN
θ value	1.80886e-08 (rank : 12)	NC score	0.376973 (rank : 14)
Query Neighborhood Hits	90	Target Neighborhood Hits	71	Shared Neighborhood Hits	16
SwissProt Accessions	Q96HP0, Q9P2F2	Gene names	DOCK6, KIAA1395
Domain Architecture
Description	Dedicator of cytokinesis protein 6.

DOCK7_HUMAN
θ value	2.36244e-08 (rank : 13)	NC score	0.389359 (rank : 13)
Query Neighborhood Hits	90	Target Neighborhood Hits	29	Shared Neighborhood Hits	15
SwissProt Accessions	Q96N67, Q6ZV32, Q8TB82, Q96NG6, Q9C092	Gene names	DOCK7, KIAA1771
Domain Architecture	No domain graphic available
Description	Dedicator of cytokinesis protein 7.

DOCK8_MOUSE
θ value	1.53129e-07 (rank : 14)	NC score	0.401101 (rank : 11)
Query Neighborhood Hits	90	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	Q8C147, Q6PIS0, Q7TMQ5, Q8K105, Q9DBQ2	Gene names	Dock8
Domain Architecture	No domain graphic available
Description	Dedicator of cytokinesis protein 8.

DNMBP_HUMAN
θ value	0.00869519 (rank : 15)	NC score	0.130119 (rank : 15)
Query Neighborhood Hits	90	Target Neighborhood Hits	413	Shared Neighborhood Hits	50
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

VINEX_MOUSE
θ value	0.0113563 (rank : 16)	NC score	0.123638 (rank : 17)
Query Neighborhood Hits	90	Target Neighborhood Hits	286	Shared Neighborhood Hits	47
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ITSN1_HUMAN
θ value	0.0193708 (rank : 17)	NC score	0.061209 (rank : 35)
Query Neighborhood Hits	90	Target Neighborhood Hits	1757	Shared Neighborhood Hits	61
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
θ value	0.0193708 (rank : 18)	NC score	0.062311 (rank : 33)
Query Neighborhood Hits	90	Target Neighborhood Hits	1669	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

OPA1_HUMAN
θ value	0.0563607 (rank : 19)	NC score	0.065893 (rank : 31)
Query Neighborhood Hits	90	Target Neighborhood Hits	85	Shared Neighborhood Hits	5
SwissProt Accessions	O60313	Gene names	OPA1, KIAA0567
Domain Architecture
Description	Dynamin-like 120 kDa protein, mitochondrial precursor (Optic atrophy protein 1) [Contains: Dynamin-like 120 kDa protein, form S1].

OPA1_MOUSE
θ value	0.0563607 (rank : 20)	NC score	0.066394 (rank : 30)
Query Neighborhood Hits	90	Target Neighborhood Hits	79	Shared Neighborhood Hits	7
SwissProt Accessions	P58281, Q3ULA5, Q8BKU7, Q8BLL3, Q8BM08, Q8R3J7	Gene names	Opa1
Domain Architecture
Description	Dynamin-like 120 kDa protein, mitochondrial precursor (Optic atrophy protein 1 homolog) (Large GTP-binding protein) (LargeG) [Contains: Dynamin-like 120 kDa protein, form S1].

VINEX_HUMAN
θ value	0.0563607 (rank : 21)	NC score	0.124047 (rank : 16)
Query Neighborhood Hits	90	Target Neighborhood Hits	270	Shared Neighborhood Hits	47
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

GCP5_HUMAN
θ value	0.0736092 (rank : 22)	NC score	0.074790 (rank : 27)
Query Neighborhood Hits	90	Target Neighborhood Hits	41	Shared Neighborhood Hits	5
SwissProt Accessions	Q96RT8, Q96PY8	Gene names	TUBGCP5, GCP5, KIAA1899
Domain Architecture
Description	Gamma-tubulin complex component 5 (GCP-5).

DNMBP_MOUSE
θ value	0.0961366 (rank : 23)	NC score	0.121397 (rank : 18)
Query Neighborhood Hits	90	Target Neighborhood Hits	435	Shared Neighborhood Hits	49
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

GRAP2_HUMAN
θ value	0.0961366 (rank : 24)	NC score	0.063901 (rank : 32)
Query Neighborhood Hits	90	Target Neighborhood Hits	304	Shared Neighborhood Hits	42
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP_HUMAN
θ value	0.0961366 (rank : 25)	NC score	0.070747 (rank : 29)
Query Neighborhood Hits	90	Target Neighborhood Hits	307	Shared Neighborhood Hits	45
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

HCLS1_HUMAN
θ value	0.163984 (rank : 26)	NC score	0.100536 (rank : 19)
Query Neighborhood Hits	90	Target Neighborhood Hits	358	Shared Neighborhood Hits	45
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

CD2AP_HUMAN
θ value	0.21417 (rank : 27)	NC score	0.084794 (rank : 24)
Query Neighborhood Hits	90	Target Neighborhood Hits	315	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

GRAP_MOUSE
θ value	0.21417 (rank : 28)	NC score	0.071259 (rank : 28)
Query Neighborhood Hits	90	Target Neighborhood Hits	309	Shared Neighborhood Hits	45
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

PON3_MOUSE
θ value	0.21417 (rank : 29)	NC score	0.030636 (rank : 57)
Query Neighborhood Hits	90	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q62087, Q8C2I7	Gene names	Pon3
Domain Architecture
Description	Serum paraoxonase/lactonase 3 (EC 3.1.1.-).

DDEF1_MOUSE
θ value	0.47712 (rank : 30)	NC score	0.047735 (rank : 50)
Query Neighborhood Hits	90	Target Neighborhood Hits	592	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

HCLS1_MOUSE
θ value	0.47712 (rank : 31)	NC score	0.085104 (rank : 22)
Query Neighborhood Hits	90	Target Neighborhood Hits	329	Shared Neighborhood Hits	43
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

DDEF2_MOUSE
θ value	0.62314 (rank : 32)	NC score	0.050362 (rank : 44)
Query Neighborhood Hits	90	Target Neighborhood Hits	625	Shared Neighborhood Hits	41
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

EHMT2_MOUSE
θ value	0.62314 (rank : 33)	NC score	0.009793 (rank : 87)
Query Neighborhood Hits	90	Target Neighborhood Hits	750	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

GRAP2_MOUSE
θ value	0.62314 (rank : 34)	NC score	0.061581 (rank : 34)
Query Neighborhood Hits	90	Target Neighborhood Hits	297	Shared Neighborhood Hits	42
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

SRC8_HUMAN
θ value	0.62314 (rank : 35)	NC score	0.084863 (rank : 23)
Query Neighborhood Hits	90	Target Neighborhood Hits	269	Shared Neighborhood Hits	45
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

CD2AP_MOUSE
θ value	0.813845 (rank : 36)	NC score	0.082063 (rank : 26)
Query Neighborhood Hits	90	Target Neighborhood Hits	336	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

ERGI2_HUMAN
θ value	0.813845 (rank : 37)	NC score	0.038579 (rank : 56)
Query Neighborhood Hits	90	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	Q96RQ1, Q53GY2, Q8N2Q9, Q9BVV9, Q9NZA3	Gene names	ERGIC2, ERV41, PTX1
Domain Architecture	No domain graphic available
Description	Endoplasmic reticulum-Golgi intermediate compartment protein 2.

HOOK1_HUMAN
θ value	0.813845 (rank : 38)	NC score	0.019255 (rank : 62)
Query Neighborhood Hits	90	Target Neighborhood Hits	942	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UJC3, O60561, Q5TG44	Gene names	HOOK1
Domain Architecture
Description	Hook homolog 1 (h-hook1) (hHK1).

REST_HUMAN
θ value	0.813845 (rank : 39)	NC score	0.015720 (rank : 68)
Query Neighborhood Hits	90	Target Neighborhood Hits	1605	Shared Neighborhood Hits	25
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

SRC8_MOUSE
θ value	0.813845 (rank : 40)	NC score	0.082994 (rank : 25)
Query Neighborhood Hits	90	Target Neighborhood Hits	292	Shared Neighborhood Hits	45
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

GBP1_HUMAN
θ value	1.06291 (rank : 41)	NC score	0.014051 (rank : 73)
Query Neighborhood Hits	90	Target Neighborhood Hits	339	Shared Neighborhood Hits	11
SwissProt Accessions	P32455	Gene names	GBP1
Domain Architecture
Description	Interferon-induced guanylate-binding protein 1 (GTP-binding protein 1) (Guanine nucleotide-binding protein 1) (GBP-1) (HuGBP-1).

GCC2_HUMAN
θ value	1.06291 (rank : 42)	NC score	0.013731 (rank : 74)
Query Neighborhood Hits	90	Target Neighborhood Hits	1558	Shared Neighborhood Hits	25
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

MACF1_HUMAN
θ value	1.06291 (rank : 43)	NC score	0.017932 (rank : 64)
Query Neighborhood Hits	90	Target Neighborhood Hits	1341	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

RBP24_HUMAN
θ value	1.06291 (rank : 44)	NC score	0.013650 (rank : 75)
Query Neighborhood Hits	90	Target Neighborhood Hits	1559	Shared Neighborhood Hits	25
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

SYNE2_HUMAN
θ value	1.06291 (rank : 45)	NC score	0.019228 (rank : 63)
Query Neighborhood Hits	90	Target Neighborhood Hits	1323	Shared Neighborhood Hits	25
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

DDEF2_HUMAN
θ value	1.38821 (rank : 46)	NC score	0.046436 (rank : 51)
Query Neighborhood Hits	90	Target Neighborhood Hits	599	Shared Neighborhood Hits	46
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

EDEM1_MOUSE
θ value	1.38821 (rank : 47)	NC score	0.022642 (rank : 60)
Query Neighborhood Hits	90	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	Q925U4	Gene names	Edem1, Edem
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 1.

NAL14_HUMAN
θ value	1.38821 (rank : 48)	NC score	0.011502 (rank : 82)
Query Neighborhood Hits	90	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	Q86W24, Q7RTR6	Gene names	NALP14, NOD5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 14 (Nucleotide-binding oligomerization domain protein 5).

CHD1_HUMAN
θ value	1.81305 (rank : 49)	NC score	0.012146 (rank : 80)
Query Neighborhood Hits	90	Target Neighborhood Hits	337	Shared Neighborhood Hits	5
SwissProt Accessions	O14646	Gene names	CHD1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

HCK_MOUSE
θ value	1.81305 (rank : 50)	NC score	0.015268 (rank : 70)
Query Neighborhood Hits	90	Target Neighborhood Hits	1029	Shared Neighborhood Hits	41
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

LYN_MOUSE
θ value	1.81305 (rank : 51)	NC score	0.017777 (rank : 65)
Query Neighborhood Hits	90	Target Neighborhood Hits	1023	Shared Neighborhood Hits	42
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MACF1_MOUSE
θ value	1.81305 (rank : 52)	NC score	0.015511 (rank : 69)
Query Neighborhood Hits	90	Target Neighborhood Hits	1313	Shared Neighborhood Hits	19
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

AHI1_HUMAN
θ value	2.36792 (rank : 53)	NC score	0.048240 (rank : 49)
Query Neighborhood Hits	90	Target Neighborhood Hits	537	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

AHI1_MOUSE
θ value	2.36792 (rank : 54)	NC score	0.049370 (rank : 47)
Query Neighborhood Hits	90	Target Neighborhood Hits	496	Shared Neighborhood Hits	44
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

GRB2_HUMAN
θ value	2.36792 (rank : 55)	NC score	0.053837 (rank : 40)
Query Neighborhood Hits	90	Target Neighborhood Hits	310	Shared Neighborhood Hits	42
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	2.36792 (rank : 56)	NC score	0.053703 (rank : 41)
Query Neighborhood Hits	90	Target Neighborhood Hits	312	Shared Neighborhood Hits	42
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

MSRE_HUMAN
θ value	2.36792 (rank : 57)	NC score	0.007531 (rank : 92)
Query Neighborhood Hits	90	Target Neighborhood Hits	298	Shared Neighborhood Hits	10
SwissProt Accessions	P21757, P21759, Q45F10	Gene names	MSR1, SCARA1
Domain Architecture
Description	Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor class A member 1) (CD204 antigen).

NCF4_MOUSE
θ value	3.0926 (rank : 58)	NC score	0.049277 (rank : 48)
Query Neighborhood Hits	90	Target Neighborhood Hits	177	Shared Neighborhood Hits	34
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

SPTA1_HUMAN
θ value	3.0926 (rank : 59)	NC score	0.030415 (rank : 58)
Query Neighborhood Hits	90	Target Neighborhood Hits	748	Shared Neighborhood Hits	55
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SRBS1_HUMAN
θ value	3.0926 (rank : 60)	NC score	0.098925 (rank : 20)
Query Neighborhood Hits	90	Target Neighborhood Hits	396	Shared Neighborhood Hits	48
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

EDEM1_HUMAN
θ value	4.03905 (rank : 61)	NC score	0.014852 (rank : 71)
Query Neighborhood Hits	90	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	Q92611	Gene names	EDEM1, EDEM, KIAA0212
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 1.

LYN_HUMAN
θ value	4.03905 (rank : 62)	NC score	0.017076 (rank : 67)
Query Neighborhood Hits	90	Target Neighborhood Hits	1022	Shared Neighborhood Hits	42
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

NCF4_HUMAN
θ value	4.03905 (rank : 63)	NC score	0.055399 (rank : 38)
Query Neighborhood Hits	90	Target Neighborhood Hits	161	Shared Neighborhood Hits	35
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

PIAS4_MOUSE
θ value	4.03905 (rank : 64)	NC score	0.007688 (rank : 91)
Query Neighborhood Hits	90	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JM05, Q8R165	Gene names	Pias4, Piasg
Domain Architecture
Description	Protein inhibitor of activated STAT protein 4 (Protein inhibitor of activated STAT protein gamma) (PIAS-gamma) (PIASy).

VAV2_HUMAN
θ value	4.03905 (rank : 65)	NC score	0.044244 (rank : 52)
Query Neighborhood Hits	90	Target Neighborhood Hits	453	Shared Neighborhood Hits	43
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

ANGP1_HUMAN
θ value	5.27518 (rank : 66)	NC score	0.005027 (rank : 95)
Query Neighborhood Hits	90	Target Neighborhood Hits	254	Shared Neighborhood Hits	9
SwissProt Accessions	Q15389	Gene names	ANGPT1, KIAA0003
Domain Architecture
Description	Angiopoietin-1 precursor (ANG-1).

APOB_HUMAN
θ value	5.27518 (rank : 67)	NC score	0.040994 (rank : 55)
Query Neighborhood Hits	90	Target Neighborhood Hits	202	Shared Neighborhood Hits	13
SwissProt Accessions	P04114, O00502, P78479, P78480, P78481, Q13779, Q13785, Q13786, Q13787, Q13788, Q7Z600, Q9UMN0	Gene names	APOB
Domain Architecture
Description	Apolipoprotein B-100 precursor (Apo B-100) [Contains: Apolipoprotein B-48 (Apo B-48)].

CT112_MOUSE
θ value	5.27518 (rank : 68)	NC score	0.020121 (rank : 61)
Query Neighborhood Hits	90	Target Neighborhood Hits	35	Shared Neighborhood Hits	6
SwissProt Accessions	Q6DIB4	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf112 homolog.

PHF14_HUMAN
θ value	5.27518 (rank : 69)	NC score	0.011199 (rank : 83)
Query Neighborhood Hits	90	Target Neighborhood Hits	447	Shared Neighborhood Hits	13
SwissProt Accessions	O94880	Gene names	PHF14, KIAA0783
Domain Architecture	No domain graphic available
Description	PHD finger protein 14.

SRBS1_MOUSE
θ value	5.27518 (rank : 70)	NC score	0.097165 (rank : 21)
Query Neighborhood Hits	90	Target Neighborhood Hits	409	Shared Neighborhood Hits	45
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

UTRO_HUMAN
θ value	5.27518 (rank : 71)	NC score	0.013263 (rank : 76)
Query Neighborhood Hits	90	Target Neighborhood Hits	960	Shared Neighborhood Hits	20
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

ABI2_HUMAN
θ value	6.88961 (rank : 72)	NC score	0.055312 (rank : 39)
Query Neighborhood Hits	90	Target Neighborhood Hits	350	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ARHG7_MOUSE
θ value	6.88961 (rank : 73)	NC score	0.043825 (rank : 53)
Query Neighborhood Hits	90	Target Neighborhood Hits	396	Shared Neighborhood Hits	43
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

CT112_HUMAN
θ value	6.88961 (rank : 74)	NC score	0.017363 (rank : 66)
Query Neighborhood Hits	90	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	Q96MY1, Q5JYB7, Q6P0Y4, Q9BR34, Q9NQF6	Gene names	C20orf112
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf112.

HCK_HUMAN
θ value	6.88961 (rank : 75)	NC score	0.012711 (rank : 78)
Query Neighborhood Hits	90	Target Neighborhood Hits	1035	Shared Neighborhood Hits	41
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

KTN1_MOUSE
θ value	6.88961 (rank : 76)	NC score	0.012208 (rank : 79)
Query Neighborhood Hits	90	Target Neighborhood Hits	1324	Shared Neighborhood Hits	23
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

LAMA2_HUMAN
θ value	6.88961 (rank : 77)	NC score	0.003740 (rank : 96)
Query Neighborhood Hits	90	Target Neighborhood Hits	1092	Shared Neighborhood Hits	18
SwissProt Accessions	P24043, Q14736, Q93022	Gene names	LAMA2, LAMM
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

LIMA1_MOUSE
θ value	6.88961 (rank : 78)	NC score	0.005580 (rank : 94)
Query Neighborhood Hits	90	Target Neighborhood Hits	298	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ERG0, Q9ERG1	Gene names	Lima1, D15Ertd366e, Eplin
Domain Architecture
Description	LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) (mEPLIN).

SPTA1_MOUSE
θ value	6.88961 (rank : 79)	NC score	0.030104 (rank : 59)
Query Neighborhood Hits	90	Target Neighborhood Hits	675	Shared Neighborhood Hits	49
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

CSK_HUMAN
θ value	8.99809 (rank : 80)	NC score	0.010436 (rank : 85)
Query Neighborhood Hits	90	Target Neighborhood Hits	1009	Shared Neighborhood Hits	36
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	8.99809 (rank : 81)	NC score	0.010535 (rank : 84)
Query Neighborhood Hits	90	Target Neighborhood Hits	1009	Shared Neighborhood Hits	36
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

DMD_HUMAN
θ value	8.99809 (rank : 82)	NC score	0.012090 (rank : 81)
Query Neighborhood Hits	90	Target Neighborhood Hits	1135	Shared Neighborhood Hits	24
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

P66B_MOUSE
θ value	8.99809 (rank : 83)	NC score	0.006718 (rank : 93)
Query Neighborhood Hits	90	Target Neighborhood Hits	64	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VHR5, Q8C9Q3	Gene names	Gatad2b
Domain Architecture	No domain graphic available
Description	Transcriptional repressor p66 beta (p66/p68) (GATA zinc finger domain- containing protein 2B).

PELP1_MOUSE
θ value	8.99809 (rank : 84)	NC score	0.013025 (rank : 77)
Query Neighborhood Hits	90	Target Neighborhood Hits	709	Shared Neighborhood Hits	12
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

PTK6_MOUSE
θ value	8.99809 (rank : 85)	NC score	0.009391 (rank : 88)
Query Neighborhood Hits	90	Target Neighborhood Hits	1026	Shared Neighborhood Hits	36
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

SF3B1_HUMAN
θ value	8.99809 (rank : 86)	NC score	0.008217 (rank : 89)
Query Neighborhood Hits	90	Target Neighborhood Hits	341	Shared Neighborhood Hits	4
SwissProt Accessions	O75533	Gene names	SF3B1, SAP155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SF3B1_MOUSE
θ value	8.99809 (rank : 87)	NC score	0.008196 (rank : 90)
Query Neighborhood Hits	90	Target Neighborhood Hits	352	Shared Neighborhood Hits	4
SwissProt Accessions	Q99NB9, Q9CSK5	Gene names	Sf3b1, Sap155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SYCP2_HUMAN
θ value	8.99809 (rank : 88)	NC score	0.010364 (rank : 86)
Query Neighborhood Hits	90	Target Neighborhood Hits	230	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BX26, O75763, Q5JX11, Q9NTX8, Q9UG27	Gene names	SYCP2, SCP2
Domain Architecture	No domain graphic available
Description	Synaptonemal complex protein 2 (SCP-2) (Synaptonemal complex lateral element protein) (hsSCP2).

T53I1_HUMAN
θ value	8.99809 (rank : 89)	NC score	0.014245 (rank : 72)
Query Neighborhood Hits	90	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q96A56, Q969R9	Gene names	TP53INP1, P53DINP1, SIP
Domain Architecture	No domain graphic available
Description	Tumor protein p53-inducible nuclear protein 1 (p53-dependent damage- inducible nuclear protein 1) (p53DINP1) (Stress-induced protein).

VAV2_MOUSE
θ value	8.99809 (rank : 90)	NC score	0.041590 (rank : 54)
Query Neighborhood Hits	90	Target Neighborhood Hits	456	Shared Neighborhood Hits	44
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ABI1_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.050350 (rank : 45)
Query Neighborhood Hits	90	Target Neighborhood Hits	257	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 92)	NC score	0.050076 (rank : 46)
Query Neighborhood Hits	90	Target Neighborhood Hits	246	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_MOUSE
θ value	θ > 10 (rank : 93)	NC score	0.051652 (rank : 43)
Query Neighborhood Hits	90	Target Neighborhood Hits	266	Shared Neighborhood Hits	39
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

NCF2_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.052895 (rank : 42)
Query Neighborhood Hits	90	Target Neighborhood Hits	229	Shared Neighborhood Hits	40
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

SH3K1_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.057295 (rank : 36)
Query Neighborhood Hits	90	Target Neighborhood Hits	341	Shared Neighborhood Hits	37
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 96)	NC score	0.056043 (rank : 37)
Query Neighborhood Hits	90	Target Neighborhood Hits	332	Shared Neighborhood Hits	39
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

Hits sorted by NC score

DOCK2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	90	Target Neighborhood Hits	90	Shared Neighborhood Hits	90
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

DOCK2_MOUSE
NC score	0.995549 (rank : 2)	θ value	0 (rank : 3)
Query Neighborhood Hits	90	Target Neighborhood Hits	104	Shared Neighborhood Hits	65
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

DOCK1_HUMAN
NC score	0.968881 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	90	Target Neighborhood Hits	191	Shared Neighborhood Hits	54
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

DOCK3_HUMAN
NC score	0.967079 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	90	Target Neighborhood Hits	87	Shared Neighborhood Hits	29
SwissProt Accessions	Q8IZD9, O15017	Gene names	DOCK3, KIAA0299, MOCA
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

DOCK3_MOUSE
NC score	0.966041 (rank : 5)	θ value	0 (rank : 5)
Query Neighborhood Hits	90	Target Neighborhood Hits	93	Shared Neighborhood Hits	28
SwissProt Accessions	Q8CIQ7	Gene names	Dock3, Moca
Domain Architecture
Description	Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP protein).

DOCK4_MOUSE
NC score	0.955973 (rank : 6)	θ value	0 (rank : 7)
Query Neighborhood Hits	90	Target Neighborhood Hits	210	Shared Neighborhood Hits	28
SwissProt Accessions	P59764	Gene names	Dock4, Kiaa0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

DOCK4_HUMAN
NC score	0.955163 (rank : 7)	θ value	0 (rank : 6)
Query Neighborhood Hits	90	Target Neighborhood Hits	237	Shared Neighborhood Hits	27
SwissProt Accessions	Q8N1I0, O14584, O94824, Q8NB45	Gene names	DOCK4, KIAA0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

DOC10_HUMAN
NC score	0.449803 (rank : 8)	θ value	1.52774e-15 (rank : 8)
Query Neighborhood Hits	90	Target Neighborhood Hits	88	Shared Neighborhood Hits	14
SwissProt Accessions	Q96BY6, O75178, Q9NW06, Q9NXI8	Gene names	DOCK10, KIAA0694
Domain Architecture
Description	Dedicator of cytokinesis protein 10 (Protein zizimin 3).

DOCK9_MOUSE
NC score	0.407731 (rank : 9)	θ value	2.52405e-10 (rank : 10)
Query Neighborhood Hits	90	Target Neighborhood Hits	79	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BIK4, Q921Y6	Gene names	Dock9, D14Wsu89e, Kiaa1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

DOCK9_HUMAN
NC score	0.405538 (rank : 10)	θ value	1.47974e-10 (rank : 9)
Query Neighborhood Hits	90	Target Neighborhood Hits	82	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BZ29, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4	Gene names	DOCK9, KIAA1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

DOCK8_MOUSE
NC score	0.401101 (rank : 11)	θ value	1.53129e-07 (rank : 14)
Query Neighborhood Hits	90	Target Neighborhood Hits	38	Shared Neighborhood Hits	14
SwissProt Accessions	Q8C147, Q6PIS0, Q7TMQ5, Q8K105, Q9DBQ2	Gene names	Dock8
Domain Architecture	No domain graphic available
Description	Dedicator of cytokinesis protein 8.

DOCK8_HUMAN
NC score	0.395061 (rank : 12)	θ value	5.62301e-10 (rank : 11)
Query Neighborhood Hits	90	Target Neighborhood Hits	42	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NF50, Q3MV16, Q5JPJ1, Q8TEP1, Q8WUY2, Q9BYJ5, Q9H1Q2, Q9H1Q3, Q9H308, Q9H7P2	Gene names	DOCK8
Domain Architecture	No domain graphic available
Description	Dedicator of cytokinesis protein 8.

DOCK7_HUMAN
NC score	0.389359 (rank : 13)	θ value	2.36244e-08 (rank : 13)
Query Neighborhood Hits	90	Target Neighborhood Hits	29	Shared Neighborhood Hits	15
SwissProt Accessions	Q96N67, Q6ZV32, Q8TB82, Q96NG6, Q9C092	Gene names	DOCK7, KIAA1771
Domain Architecture	No domain graphic available
Description	Dedicator of cytokinesis protein 7.

DOCK6_HUMAN
NC score	0.376973 (rank : 14)	θ value	1.80886e-08 (rank : 12)
Query Neighborhood Hits	90	Target Neighborhood Hits	71	Shared Neighborhood Hits	16
SwissProt Accessions	Q96HP0, Q9P2F2	Gene names	DOCK6, KIAA1395
Domain Architecture
Description	Dedicator of cytokinesis protein 6.

DNMBP_HUMAN
NC score	0.130119 (rank : 15)	θ value	0.00869519 (rank : 15)
Query Neighborhood Hits	90	Target Neighborhood Hits	413	Shared Neighborhood Hits	50
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

VINEX_HUMAN
NC score	0.124047 (rank : 16)	θ value	0.0563607 (rank : 21)
Query Neighborhood Hits	90	Target Neighborhood Hits	270	Shared Neighborhood Hits	47
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
NC score	0.123638 (rank : 17)	θ value	0.0113563 (rank : 16)
Query Neighborhood Hits	90	Target Neighborhood Hits	286	Shared Neighborhood Hits	47
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

DNMBP_MOUSE
NC score	0.121397 (rank : 18)	θ value	0.0961366 (rank : 23)
Query Neighborhood Hits	90	Target Neighborhood Hits	435	Shared Neighborhood Hits	49
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

HCLS1_HUMAN
NC score	0.100536 (rank : 19)	θ value	0.163984 (rank : 26)
Query Neighborhood Hits	90	Target Neighborhood Hits	358	Shared Neighborhood Hits	45
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

SRBS1_HUMAN
NC score	0.098925 (rank : 20)	θ value	3.0926 (rank : 60)
Query Neighborhood Hits	90	Target Neighborhood Hits	396	Shared Neighborhood Hits	48
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
NC score	0.097165 (rank : 21)	θ value	5.27518 (rank : 70)
Query Neighborhood Hits	90	Target Neighborhood Hits	409	Shared Neighborhood Hits	45
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

HCLS1_MOUSE
NC score	0.085104 (rank : 22)	θ value	0.47712 (rank : 31)
Query Neighborhood Hits	90	Target Neighborhood Hits	329	Shared Neighborhood Hits	43
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

SRC8_HUMAN
NC score	0.084863 (rank : 23)	θ value	0.62314 (rank : 35)
Query Neighborhood Hits	90	Target Neighborhood Hits	269	Shared Neighborhood Hits	45
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

CD2AP_HUMAN
NC score	0.084794 (rank : 24)	θ value	0.21417 (rank : 27)
Query Neighborhood Hits	90	Target Neighborhood Hits	315	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SRC8_MOUSE
NC score	0.082994 (rank : 25)	θ value	0.813845 (rank : 40)
Query Neighborhood Hits	90	Target Neighborhood Hits	292	Shared Neighborhood Hits	45
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

CD2AP_MOUSE
NC score	0.082063 (rank : 26)	θ value	0.813845 (rank : 36)
Query Neighborhood Hits	90	Target Neighborhood Hits	336	Shared Neighborhood Hits	43
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

GCP5_HUMAN
NC score	0.074790 (rank : 27)	θ value	0.0736092 (rank : 22)
Query Neighborhood Hits	90	Target Neighborhood Hits	41	Shared Neighborhood Hits	5
SwissProt Accessions	Q96RT8, Q96PY8	Gene names	TUBGCP5, GCP5, KIAA1899
Domain Architecture
Description	Gamma-tubulin complex component 5 (GCP-5).

GRAP_MOUSE
NC score	0.071259 (rank : 28)	θ value	0.21417 (rank : 28)
Query Neighborhood Hits	90	Target Neighborhood Hits	309	Shared Neighborhood Hits	45
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRAP_HUMAN
NC score	0.070747 (rank : 29)	θ value	0.0961366 (rank : 25)
Query Neighborhood Hits	90	Target Neighborhood Hits	307	Shared Neighborhood Hits	45
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

OPA1_MOUSE
NC score	0.066394 (rank : 30)	θ value	0.0563607 (rank : 20)
Query Neighborhood Hits	90	Target Neighborhood Hits	79	Shared Neighborhood Hits	7
SwissProt Accessions	P58281, Q3ULA5, Q8BKU7, Q8BLL3, Q8BM08, Q8R3J7	Gene names	Opa1
Domain Architecture
Description	Dynamin-like 120 kDa protein, mitochondrial precursor (Optic atrophy protein 1 homolog) (Large GTP-binding protein) (LargeG) [Contains: Dynamin-like 120 kDa protein, form S1].

OPA1_HUMAN
NC score	0.065893 (rank : 31)	θ value	0.0563607 (rank : 19)
Query Neighborhood Hits	90	Target Neighborhood Hits	85	Shared Neighborhood Hits	5
SwissProt Accessions	O60313	Gene names	OPA1, KIAA0567
Domain Architecture
Description	Dynamin-like 120 kDa protein, mitochondrial precursor (Optic atrophy protein 1) [Contains: Dynamin-like 120 kDa protein, form S1].

GRAP2_HUMAN
NC score	0.063901 (rank : 32)	θ value	0.0961366 (rank : 24)
Query Neighborhood Hits	90	Target Neighborhood Hits	304	Shared Neighborhood Hits	42
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

ITSN1_MOUSE
NC score	0.062311 (rank : 33)	θ value	0.0193708 (rank : 18)
Query Neighborhood Hits	90	Target Neighborhood Hits	1669	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

GRAP2_MOUSE
NC score	0.061581 (rank : 34)	θ value	0.62314 (rank : 34)
Query Neighborhood Hits	90	Target Neighborhood Hits	297	Shared Neighborhood Hits	42
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

ITSN1_HUMAN
NC score	0.061209 (rank : 35)	θ value	0.0193708 (rank : 17)
Query Neighborhood Hits	90	Target Neighborhood Hits	1757	Shared Neighborhood Hits	61
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

SH3K1_HUMAN
NC score	0.057295 (rank : 36)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	90	Target Neighborhood Hits	341	Shared Neighborhood Hits	37
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
NC score	0.056043 (rank : 37)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	90	Target Neighborhood Hits	332	Shared Neighborhood Hits	39
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

NCF4_HUMAN
NC score	0.055399 (rank : 38)	θ value	4.03905 (rank : 63)
Query Neighborhood Hits	90	Target Neighborhood Hits	161	Shared Neighborhood Hits	35
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

ABI2_HUMAN
NC score	0.055312 (rank : 39)	θ value	6.88961 (rank : 72)
Query Neighborhood Hits	90	Target Neighborhood Hits	350	Shared Neighborhood Hits	40
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

GRB2_HUMAN
NC score	0.053837 (rank : 40)	θ value	2.36792 (rank : 55)
Query Neighborhood Hits	90	Target Neighborhood Hits	310	Shared Neighborhood Hits	42
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.053703 (rank : 41)	θ value	2.36792 (rank : 56)
Query Neighborhood Hits	90	Target Neighborhood Hits	312	Shared Neighborhood Hits	42
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

NCF2_HUMAN
NC score	0.052895 (rank : 42)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	90	Target Neighborhood Hits	229	Shared Neighborhood Hits	40
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

ABI2_MOUSE
NC score	0.051652 (rank : 43)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	90	Target Neighborhood Hits	266	Shared Neighborhood Hits	39
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

DDEF2_MOUSE
NC score	0.050362 (rank : 44)	θ value	0.62314 (rank : 32)
Query Neighborhood Hits	90	Target Neighborhood Hits	625	Shared Neighborhood Hits	41
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

ABI1_HUMAN
NC score	0.050350 (rank : 45)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	90	Target Neighborhood Hits	257	Shared Neighborhood Hits	39
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
NC score	0.050076 (rank : 46)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	90	Target Neighborhood Hits	246	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

AHI1_MOUSE
NC score	0.049370 (rank : 47)	θ value	2.36792 (rank : 54)
Query Neighborhood Hits	90	Target Neighborhood Hits	496	Shared Neighborhood Hits	44
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

NCF4_MOUSE
NC score	0.049277 (rank : 48)	θ value	3.0926 (rank : 58)
Query Neighborhood Hits	90	Target Neighborhood Hits	177	Shared Neighborhood Hits	34
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

AHI1_HUMAN
NC score	0.048240 (rank : 49)	θ value	2.36792 (rank : 53)
Query Neighborhood Hits	90	Target Neighborhood Hits	537	Shared Neighborhood Hits	43
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

DDEF1_MOUSE
NC score	0.047735 (rank : 50)	θ value	0.47712 (rank : 30)
Query Neighborhood Hits	90	Target Neighborhood Hits	592	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_HUMAN
NC score	0.046436 (rank : 51)	θ value	1.38821 (rank : 46)
Query Neighborhood Hits	90	Target Neighborhood Hits	599	Shared Neighborhood Hits	46
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

VAV2_HUMAN
NC score	0.044244 (rank : 52)	θ value	4.03905 (rank : 65)
Query Neighborhood Hits	90	Target Neighborhood Hits	453	Shared Neighborhood Hits	43
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

ARHG7_MOUSE
NC score	0.043825 (rank : 53)	θ value	6.88961 (rank : 73)
Query Neighborhood Hits	90	Target Neighborhood Hits	396	Shared Neighborhood Hits	43
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

VAV2_MOUSE
NC score	0.041590 (rank : 54)	θ value	8.99809 (rank : 90)
Query Neighborhood Hits	90	Target Neighborhood Hits	456	Shared Neighborhood Hits	44
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

APOB_HUMAN
NC score	0.040994 (rank : 55)	θ value	5.27518 (rank : 67)
Query Neighborhood Hits	90	Target Neighborhood Hits	202	Shared Neighborhood Hits	13
SwissProt Accessions	P04114, O00502, P78479, P78480, P78481, Q13779, Q13785, Q13786, Q13787, Q13788, Q7Z600, Q9UMN0	Gene names	APOB
Domain Architecture
Description	Apolipoprotein B-100 precursor (Apo B-100) [Contains: Apolipoprotein B-48 (Apo B-48)].

ERGI2_HUMAN
NC score	0.038579 (rank : 56)	θ value	0.813845 (rank : 37)
Query Neighborhood Hits	90	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	Q96RQ1, Q53GY2, Q8N2Q9, Q9BVV9, Q9NZA3	Gene names	ERGIC2, ERV41, PTX1
Domain Architecture	No domain graphic available
Description	Endoplasmic reticulum-Golgi intermediate compartment protein 2.

PON3_MOUSE
NC score	0.030636 (rank : 57)	θ value	0.21417 (rank : 29)
Query Neighborhood Hits	90	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q62087, Q8C2I7	Gene names	Pon3
Domain Architecture
Description	Serum paraoxonase/lactonase 3 (EC 3.1.1.-).

SPTA1_HUMAN
NC score	0.030415 (rank : 58)	θ value	3.0926 (rank : 59)
Query Neighborhood Hits	90	Target Neighborhood Hits	748	Shared Neighborhood Hits	55
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA1_MOUSE
NC score	0.030104 (rank : 59)	θ value	6.88961 (rank : 79)
Query Neighborhood Hits	90	Target Neighborhood Hits	675	Shared Neighborhood Hits	49
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

EDEM1_MOUSE
NC score	0.022642 (rank : 60)	θ value	1.38821 (rank : 47)
Query Neighborhood Hits	90	Target Neighborhood Hits	23	Shared Neighborhood Hits	4
SwissProt Accessions	Q925U4	Gene names	Edem1, Edem
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 1.

CT112_MOUSE
NC score	0.020121 (rank : 61)	θ value	5.27518 (rank : 68)
Query Neighborhood Hits	90	Target Neighborhood Hits	35	Shared Neighborhood Hits	6
SwissProt Accessions	Q6DIB4	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf112 homolog.

HOOK1_HUMAN
NC score	0.019255 (rank : 62)	θ value	0.813845 (rank : 38)
Query Neighborhood Hits	90	Target Neighborhood Hits	942	Shared Neighborhood Hits	22
SwissProt Accessions	Q9UJC3, O60561, Q5TG44	Gene names	HOOK1
Domain Architecture
Description	Hook homolog 1 (h-hook1) (hHK1).

SYNE2_HUMAN
NC score	0.019228 (rank : 63)	θ value	1.06291 (rank : 45)
Query Neighborhood Hits	90	Target Neighborhood Hits	1323	Shared Neighborhood Hits	25
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

MACF1_HUMAN
NC score	0.017932 (rank : 64)	θ value	1.06291 (rank : 43)
Query Neighborhood Hits	90	Target Neighborhood Hits	1341	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UPN3, O75053, Q5VW20, Q8WXY2, Q9H540, Q9UKP0, Q9ULG9	Gene names	MACF1, ABP620, ACF7, KIAA0465, KIAA1251
Domain Architecture
Description	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha) (620 kDa actin-binding protein) (ABP620).

LYN_MOUSE
NC score	0.017777 (rank : 65)	θ value	1.81305 (rank : 51)
Query Neighborhood Hits	90	Target Neighborhood Hits	1023	Shared Neighborhood Hits	42
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

CT112_HUMAN
NC score	0.017363 (rank : 66)	θ value	6.88961 (rank : 74)
Query Neighborhood Hits	90	Target Neighborhood Hits	30	Shared Neighborhood Hits	4
SwissProt Accessions	Q96MY1, Q5JYB7, Q6P0Y4, Q9BR34, Q9NQF6	Gene names	C20orf112
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C20orf112.

LYN_HUMAN
NC score	0.017076 (rank : 67)	θ value	4.03905 (rank : 62)
Query Neighborhood Hits	90	Target Neighborhood Hits	1022	Shared Neighborhood Hits	42
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

REST_HUMAN
NC score	0.015720 (rank : 68)	θ value	0.813845 (rank : 39)
Query Neighborhood Hits	90	Target Neighborhood Hits	1605	Shared Neighborhood Hits	25
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

MACF1_MOUSE
NC score	0.015511 (rank : 69)	θ value	1.81305 (rank : 52)
Query Neighborhood Hits	90	Target Neighborhood Hits	1313	Shared Neighborhood Hits	19
SwissProt Accessions	Q9QXZ0, P97394, P97395, P97396	Gene names	Macf1, Acf7, Aclp7, Macf
Domain Architecture
Description	Microtubule-actin cross-linking factor 1 (Actin cross-linking family 7).

HCK_MOUSE
NC score	0.015268 (rank : 70)	θ value	1.81305 (rank : 50)
Query Neighborhood Hits	90	Target Neighborhood Hits	1029	Shared Neighborhood Hits	41
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

EDEM1_HUMAN
NC score	0.014852 (rank : 71)	θ value	4.03905 (rank : 61)
Query Neighborhood Hits	90	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	Q92611	Gene names	EDEM1, EDEM, KIAA0212
Domain Architecture
Description	ER degradation-enhancing alpha-mannosidase-like 1.

T53I1_HUMAN
NC score	0.014245 (rank : 72)	θ value	8.99809 (rank : 89)
Query Neighborhood Hits	90	Target Neighborhood Hits	10	Shared Neighborhood Hits	3
SwissProt Accessions	Q96A56, Q969R9	Gene names	TP53INP1, P53DINP1, SIP
Domain Architecture	No domain graphic available
Description	Tumor protein p53-inducible nuclear protein 1 (p53-dependent damage- inducible nuclear protein 1) (p53DINP1) (Stress-induced protein).

GBP1_HUMAN
NC score	0.014051 (rank : 73)	θ value	1.06291 (rank : 41)
Query Neighborhood Hits	90	Target Neighborhood Hits	339	Shared Neighborhood Hits	11
SwissProt Accessions	P32455	Gene names	GBP1
Domain Architecture
Description	Interferon-induced guanylate-binding protein 1 (GTP-binding protein 1) (Guanine nucleotide-binding protein 1) (GBP-1) (HuGBP-1).

GCC2_HUMAN
NC score	0.013731 (rank : 74)	θ value	1.06291 (rank : 42)
Query Neighborhood Hits	90	Target Neighborhood Hits	1558	Shared Neighborhood Hits	25
SwissProt Accessions	Q8IWJ2, O15045, Q8TDH3, Q9H2G8	Gene names	GCC2, KIAA0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185) (CTCL tumor antigen se1-1) (CLL-associated antigen KW- 11) (NY-REN-53 antigen).

RBP24_HUMAN
NC score	0.013650 (rank : 75)	θ value	1.06291 (rank : 44)
Query Neighborhood Hits	90	Target Neighborhood Hits	1559	Shared Neighborhood Hits	25
SwissProt Accessions	Q4ZG46	Gene names	RANBP2L4
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 4 (RanBP2L4).

UTRO_HUMAN
NC score	0.013263 (rank : 76)	θ value	5.27518 (rank : 71)
Query Neighborhood Hits	90	Target Neighborhood Hits	960	Shared Neighborhood Hits	20
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

PELP1_MOUSE
NC score	0.013025 (rank : 77)	θ value	8.99809 (rank : 84)
Query Neighborhood Hits	90	Target Neighborhood Hits	709	Shared Neighborhood Hits	12
SwissProt Accessions	Q9DBD5, Q5F2E2, Q6PEM0, Q91YM9	Gene names	Pelp1, Mnar
Domain Architecture	No domain graphic available
Description	Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of nongenomic activity of estrogen receptor).

HCK_HUMAN
NC score	0.012711 (rank : 78)	θ value	6.88961 (rank : 75)
Query Neighborhood Hits	90	Target Neighborhood Hits	1035	Shared Neighborhood Hits	41
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

KTN1_MOUSE
NC score	0.012208 (rank : 79)	θ value	6.88961 (rank : 76)
Query Neighborhood Hits	90	Target Neighborhood Hits	1324	Shared Neighborhood Hits	23
SwissProt Accessions	Q61595, Q8BG49, Q8BHF4, Q8BHM8, Q8C9Y5, Q8CG51, Q8CG52, Q8CG53, Q8CG54, Q8CG55, Q8CG56, Q8CG57, Q8CG58, Q8CG59, Q8CG60, Q8CG61, Q8CG62, Q8CG63	Gene names	Ktn1
Domain Architecture	No domain graphic available
Description	Kinectin.

CHD1_HUMAN
NC score	0.012146 (rank : 80)	θ value	1.81305 (rank : 49)
Query Neighborhood Hits	90	Target Neighborhood Hits	337	Shared Neighborhood Hits	5
SwissProt Accessions	O14646	Gene names	CHD1
Domain Architecture
Description	Chromodomain-helicase-DNA-binding protein 1 (EC 3.6.1.-) (ATP- dependent helicase CHD1) (CHD-1).

DMD_HUMAN
NC score	0.012090 (rank : 81)	θ value	8.99809 (rank : 82)
Query Neighborhood Hits	90	Target Neighborhood Hits	1135	Shared Neighborhood Hits	24
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

NAL14_HUMAN
NC score	0.011502 (rank : 82)	θ value	1.38821 (rank : 48)
Query Neighborhood Hits	90	Target Neighborhood Hits	76	Shared Neighborhood Hits	3
SwissProt Accessions	Q86W24, Q7RTR6	Gene names	NALP14, NOD5
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 14 (Nucleotide-binding oligomerization domain protein 5).

PHF14_HUMAN
NC score	0.011199 (rank : 83)	θ value	5.27518 (rank : 69)
Query Neighborhood Hits	90	Target Neighborhood Hits	447	Shared Neighborhood Hits	13
SwissProt Accessions	O94880	Gene names	PHF14, KIAA0783
Domain Architecture	No domain graphic available
Description	PHD finger protein 14.

CSK_MOUSE
NC score	0.010535 (rank : 84)	θ value	8.99809 (rank : 81)
Query Neighborhood Hits	90	Target Neighborhood Hits	1009	Shared Neighborhood Hits	36
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CSK_HUMAN
NC score	0.010436 (rank : 85)	θ value	8.99809 (rank : 80)
Query Neighborhood Hits	90	Target Neighborhood Hits	1009	Shared Neighborhood Hits	36
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

SYCP2_HUMAN
NC score	0.010364 (rank : 86)	θ value	8.99809 (rank : 88)
Query Neighborhood Hits	90	Target Neighborhood Hits	230	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BX26, O75763, Q5JX11, Q9NTX8, Q9UG27	Gene names	SYCP2, SCP2
Domain Architecture	No domain graphic available
Description	Synaptonemal complex protein 2 (SCP-2) (Synaptonemal complex lateral element protein) (hsSCP2).

EHMT2_MOUSE
NC score	0.009793 (rank : 87)	θ value	0.62314 (rank : 33)
Query Neighborhood Hits	90	Target Neighborhood Hits	750	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Z148, Q6PE08, Q8K4R6, Q8K4R7, Q9Z149	Gene names	Ehmt2, Bat8, G9a, Ng36
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Protein G9a).

PTK6_MOUSE
NC score	0.009391 (rank : 88)	θ value	8.99809 (rank : 85)
Query Neighborhood Hits	90	Target Neighborhood Hits	1026	Shared Neighborhood Hits	36
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

SF3B1_HUMAN
NC score	0.008217 (rank : 89)	θ value	8.99809 (rank : 86)
Query Neighborhood Hits	90	Target Neighborhood Hits	341	Shared Neighborhood Hits	4
SwissProt Accessions	O75533	Gene names	SF3B1, SAP155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

SF3B1_MOUSE
NC score	0.008196 (rank : 90)	θ value	8.99809 (rank : 87)
Query Neighborhood Hits	90	Target Neighborhood Hits	352	Shared Neighborhood Hits	4
SwissProt Accessions	Q99NB9, Q9CSK5	Gene names	Sf3b1, Sap155
Domain Architecture
Description	Splicing factor 3B subunit 1 (Spliceosome-associated protein 155) (SAP 155) (SF3b155) (Pre-mRNA-splicing factor SF3b 155 kDa subunit).

PIAS4_MOUSE
NC score	0.007688 (rank : 91)	θ value	4.03905 (rank : 64)
Query Neighborhood Hits	90	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JM05, Q8R165	Gene names	Pias4, Piasg
Domain Architecture
Description	Protein inhibitor of activated STAT protein 4 (Protein inhibitor of activated STAT protein gamma) (PIAS-gamma) (PIASy).

MSRE_HUMAN
NC score	0.007531 (rank : 92)	θ value	2.36792 (rank : 57)
Query Neighborhood Hits	90	Target Neighborhood Hits	298	Shared Neighborhood Hits	10
SwissProt Accessions	P21757, P21759, Q45F10	Gene names	MSR1, SCARA1
Domain Architecture
Description	Macrophage scavenger receptor types I and II (Macrophage acetylated LDL receptor I and II) (Scavenger receptor class A member 1) (CD204 antigen).

P66B_MOUSE
NC score	0.006718 (rank : 93)	θ value	8.99809 (rank : 83)
Query Neighborhood Hits	90	Target Neighborhood Hits	64	Shared Neighborhood Hits	3
SwissProt Accessions	Q8VHR5, Q8C9Q3	Gene names	Gatad2b
Domain Architecture	No domain graphic available
Description	Transcriptional repressor p66 beta (p66/p68) (GATA zinc finger domain- containing protein 2B).

LIMA1_MOUSE
NC score	0.005580 (rank : 94)	θ value	6.88961 (rank : 78)
Query Neighborhood Hits	90	Target Neighborhood Hits	298	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ERG0, Q9ERG1	Gene names	Lima1, D15Ertd366e, Eplin
Domain Architecture
Description	LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm) (mEPLIN).

ANGP1_HUMAN
NC score	0.005027 (rank : 95)	θ value	5.27518 (rank : 66)
Query Neighborhood Hits	90	Target Neighborhood Hits	254	Shared Neighborhood Hits	9
SwissProt Accessions	Q15389	Gene names	ANGPT1, KIAA0003
Domain Architecture
Description	Angiopoietin-1 precursor (ANG-1).

LAMA2_HUMAN
NC score	0.003740 (rank : 96)	θ value	6.88961 (rank : 77)
Query Neighborhood Hits	90	Target Neighborhood Hits	1092	Shared Neighborhood Hits	18
SwissProt Accessions	P24043, Q14736, Q93022	Gene names	LAMA2, LAMM
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).