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Network neighborhood for query Sequence : OPA1_MOUSE

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OPA1_MOUSE
SwissProt Accessions	P58281, Q3ULA5, Q8BKU7, Q8BLL3, Q8BM08, Q8R3J7	Gene names	Opa1
Domain Architecture
Description	Dynamin-like 120 kDa protein, mitochondrial precursor (Optic atrophy protein 1 homolog) (Large GTP-binding protein) (LargeG) [Contains: Dynamin-like 120 kDa protein, form S1].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

OPA1_HUMAN
θ value	0 (rank : 1)	NC score	0.996008 (rank : 2)
Query Neighborhood Hits	79	Target Neighborhood Hits	85	Shared Neighborhood Hits	68
SwissProt Accessions	O60313	Gene names	OPA1, KIAA0567
Domain Architecture
Description	Dynamin-like 120 kDa protein, mitochondrial precursor (Optic atrophy protein 1) [Contains: Dynamin-like 120 kDa protein, form S1].

OPA1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	79	Target Neighborhood Hits	79	Shared Neighborhood Hits	79
SwissProt Accessions	P58281, Q3ULA5, Q8BKU7, Q8BLL3, Q8BM08, Q8R3J7	Gene names	Opa1
Domain Architecture
Description	Dynamin-like 120 kDa protein, mitochondrial precursor (Optic atrophy protein 1 homolog) (Large GTP-binding protein) (LargeG) [Contains: Dynamin-like 120 kDa protein, form S1].

DYN2_HUMAN
θ value	3.07116e-24 (rank : 3)	NC score	0.693121 (rank : 9)
Query Neighborhood Hits	79	Target Neighborhood Hits	112	Shared Neighborhood Hits	13
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

DYN2_MOUSE
θ value	6.84181e-24 (rank : 4)	NC score	0.692188 (rank : 10)
Query Neighborhood Hits	79	Target Neighborhood Hits	104	Shared Neighborhood Hits	13
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

DYN1_MOUSE
θ value	2.59989e-23 (rank : 5)	NC score	0.688954 (rank : 11)
Query Neighborhood Hits	79	Target Neighborhood Hits	168	Shared Neighborhood Hits	19
SwissProt Accessions	P39053, Q61358, Q61359, Q61360, Q8JZZ4, Q9CSY7, Q9QXX1	Gene names	Dnm1, Dnm
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

DYN1_HUMAN
θ value	3.39556e-23 (rank : 6)	NC score	0.684286 (rank : 12)
Query Neighborhood Hits	79	Target Neighborhood Hits	216	Shared Neighborhood Hits	18
SwissProt Accessions	Q05193	Gene names	DNM1, DNM
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

DNM1L_HUMAN
θ value	2.87452e-22 (rank : 7)	NC score	0.714856 (rank : 3)
Query Neighborhood Hits	79	Target Neighborhood Hits	39	Shared Neighborhood Hits	15
SwissProt Accessions	O00429, O14541, O60709, Q7L6B3, Q8TBT7, Q9BWM1, Q9Y5J2	Gene names	DNM1L, DLP1, DRP1
Domain Architecture	No domain graphic available
Description	Dynamin-1-like protein (EC 3.6.5.5) (Dynamin-like protein) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-related protein 1) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV).

DNM1L_MOUSE
θ value	8.36355e-22 (rank : 8)	NC score	0.713442 (rank : 4)
Query Neighborhood Hits	79	Target Neighborhood Hits	28	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K1M6, Q8BNQ5, Q8BQ64, Q8CGD0, Q8K1A1	Gene names	Dnm1l, Drp1
Domain Architecture	No domain graphic available
Description	Dynamin-1-like protein (EC 3.6.5.5) (Dynamin-related protein 1) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple).

MX1_HUMAN
θ value	1.42661e-21 (rank : 9)	NC score	0.705752 (rank : 5)
Query Neighborhood Hits	79	Target Neighborhood Hits	62	Shared Neighborhood Hits	17
SwissProt Accessions	P20591	Gene names	MX1
Domain Architecture
Description	Interferon-induced GTP-binding protein Mx1 (Interferon-regulated resistance GTP-binding protein MxA) (Interferon-induced protein p78) (IFI-78K).

DYN3_HUMAN
θ value	1.86321e-21 (rank : 10)	NC score	0.682724 (rank : 13)
Query Neighborhood Hits	79	Target Neighborhood Hits	158	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

MX2_HUMAN
θ value	1.5773e-20 (rank : 11)	NC score	0.700123 (rank : 7)
Query Neighborhood Hits	79	Target Neighborhood Hits	71	Shared Neighborhood Hits	17
SwissProt Accessions	P20592	Gene names	MX2
Domain Architecture
Description	Interferon-induced GTP-binding protein Mx2 (Interferon-regulated resistance GTP-binding protein MxB) (p78-related protein).

MX1_MOUSE
θ value	2.69047e-20 (rank : 12)	NC score	0.701981 (rank : 6)
Query Neighborhood Hits	79	Target Neighborhood Hits	60	Shared Neighborhood Hits	15
SwissProt Accessions	P09922	Gene names	Mx1
Domain Architecture
Description	Interferon-induced GTP-binding protein Mx1 (Influenza resistance protein).

MX2_MOUSE
θ value	5.07402e-19 (rank : 13)	NC score	0.695956 (rank : 8)
Query Neighborhood Hits	79	Target Neighborhood Hits	62	Shared Neighborhood Hits	15
SwissProt Accessions	Q9WVP9, Q922L4	Gene names	Mx2
Domain Architecture	No domain graphic available
Description	Interferon-induced GTP-binding protein Mx2.

REST_HUMAN
θ value	0.00020696 (rank : 14)	NC score	0.065801 (rank : 19)
Query Neighborhood Hits	79	Target Neighborhood Hits	1605	Shared Neighborhood Hits	46
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

DOCK2_MOUSE
θ value	0.00298849 (rank : 15)	NC score	0.077892 (rank : 15)
Query Neighborhood Hits	79	Target Neighborhood Hits	104	Shared Neighborhood Hits	8
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

RBCC1_HUMAN
θ value	0.0252991 (rank : 16)	NC score	0.065982 (rank : 18)
Query Neighborhood Hits	79	Target Neighborhood Hits	1023	Shared Neighborhood Hits	40
SwissProt Accessions	Q8TDY2, Q8WVU9, Q92601	Gene names	RB1CC1, KIAA0203, RBICC
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1.

TACC3_MOUSE
θ value	0.0252991 (rank : 17)	NC score	0.071958 (rank : 16)
Query Neighborhood Hits	79	Target Neighborhood Hits	607	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JJ11, Q9WVK9	Gene names	Tacc3, Aint
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ARNT-interacting protein).

DOCK2_HUMAN
θ value	0.0563607 (rank : 18)	NC score	0.066394 (rank : 17)
Query Neighborhood Hits	79	Target Neighborhood Hits	90	Shared Neighborhood Hits	7
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

K2C6G_MOUSE
θ value	0.125558 (rank : 19)	NC score	0.026236 (rank : 51)
Query Neighborhood Hits	79	Target Neighborhood Hits	452	Shared Neighborhood Hits	28
SwissProt Accessions	Q9R0H5, Q7TPF3, Q9D0X6	Gene names	Krt6g, K6irs1, Krt2-6g
Domain Architecture	No domain graphic available
Description	Keratin, type II cytoskeletal 6G (Cytokeratin-6G) (CK 6G) (K6g keratin) (Keratin-K6irs) (mK6irs1/Krt2-6g).

MFN1_HUMAN
θ value	0.21417 (rank : 20)	NC score	0.088694 (rank : 14)
Query Neighborhood Hits	79	Target Neighborhood Hits	71	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IWA4, O15323, O60639, Q9BZB5, Q9NWQ2	Gene names	MFN1
Domain Architecture
Description	Transmembrane GTPase MFN1 (EC 3.6.5.-) (Mitofusin-1) (Fzo homolog).

PALB2_HUMAN
θ value	0.279714 (rank : 21)	NC score	0.061978 (rank : 20)
Query Neighborhood Hits	79	Target Neighborhood Hits	117	Shared Neighborhood Hits	6
SwissProt Accessions	Q86YC2, Q8N7Y6, Q8ND31, Q9H6W1	Gene names	PALB2
Domain Architecture	No domain graphic available
Description	Partner and localizer of BRCA2.

FER_HUMAN
θ value	0.365318 (rank : 22)	NC score	0.009538 (rank : 70)
Query Neighborhood Hits	79	Target Neighborhood Hits	1278	Shared Neighborhood Hits	31
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

ITSN2_MOUSE
θ value	0.365318 (rank : 23)	NC score	0.030867 (rank : 47)
Query Neighborhood Hits	79	Target Neighborhood Hits	1371	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

REST_MOUSE
θ value	0.365318 (rank : 24)	NC score	0.051374 (rank : 24)
Query Neighborhood Hits	79	Target Neighborhood Hits	1506	Shared Neighborhood Hits	41
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

ANR26_MOUSE
θ value	0.47712 (rank : 25)	NC score	0.032204 (rank : 45)
Query Neighborhood Hits	79	Target Neighborhood Hits	1554	Shared Neighborhood Hits	41
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

GOGA4_HUMAN
θ value	0.47712 (rank : 26)	NC score	0.039013 (rank : 32)
Query Neighborhood Hits	79	Target Neighborhood Hits	2034	Shared Neighborhood Hits	44
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

PKHC1_HUMAN
θ value	0.62314 (rank : 27)	NC score	0.046036 (rank : 26)
Query Neighborhood Hits	79	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q96AC1, Q14840, Q86TY7	Gene names	PLEKHC1, KIND2, MIG2
Domain Architecture
Description	Pleckstrin homology domain-containing family C member 1 (Kindlin-2) (Mitogen-inducible gene 2 protein) (Mig-2).

RBCC1_MOUSE
θ value	0.813845 (rank : 28)	NC score	0.057130 (rank : 21)
Query Neighborhood Hits	79	Target Neighborhood Hits	1048	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ESK9, Q3TXX2, Q61384, Q8BRY9, Q9JK14	Gene names	Rb1cc1, Cc1, Kiaa0203
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (LaXp180 protein).

CENPE_HUMAN
θ value	1.06291 (rank : 29)	NC score	0.035849 (rank : 35)
Query Neighborhood Hits	79	Target Neighborhood Hits	2060	Shared Neighborhood Hits	47
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

DYNA_HUMAN
θ value	1.06291 (rank : 30)	NC score	0.047019 (rank : 25)
Query Neighborhood Hits	79	Target Neighborhood Hits	1194	Shared Neighborhood Hits	40
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

PKHC1_MOUSE
θ value	1.06291 (rank : 31)	NC score	0.042845 (rank : 29)
Query Neighborhood Hits	79	Target Neighborhood Hits	28	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CIB5, Q8C542, Q8K035	Gene names	Plekhc1
Domain Architecture
Description	Pleckstrin homology domain-containing family C member 1.

CKAP4_MOUSE
θ value	1.38821 (rank : 32)	NC score	0.053752 (rank : 22)
Query Neighborhood Hits	79	Target Neighborhood Hits	596	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BMK4, Q8BTK8, Q8R3F2	Gene names	Ckap4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

CROCC_HUMAN
θ value	1.38821 (rank : 33)	NC score	0.035370 (rank : 36)
Query Neighborhood Hits	79	Target Neighborhood Hits	1409	Shared Neighborhood Hits	40
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

DYNA_MOUSE
θ value	1.38821 (rank : 34)	NC score	0.045624 (rank : 27)
Query Neighborhood Hits	79	Target Neighborhood Hits	1084	Shared Neighborhood Hits	39
SwissProt Accessions	O08788	Gene names	Dctn1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued).

IFT74_MOUSE
θ value	1.38821 (rank : 35)	NC score	0.043642 (rank : 28)
Query Neighborhood Hits	79	Target Neighborhood Hits	939	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BKE9, Q80ZI3, Q9CSY1, Q9CUS0, Q9D9T5	Gene names	Ift74, Ccdc2, Cmg1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

LAMC3_HUMAN
θ value	1.38821 (rank : 36)	NC score	0.013948 (rank : 68)
Query Neighborhood Hits	79	Target Neighborhood Hits	588	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y6N6	Gene names	LAMC3
Domain Architecture
Description	Laminin gamma-3 chain precursor (Laminin 12 gamma 3 subunit).

M6PBP_MOUSE
θ value	1.38821 (rank : 37)	NC score	0.032888 (rank : 40)
Query Neighborhood Hits	79	Target Neighborhood Hits	91	Shared Neighborhood Hits	9
SwissProt Accessions	Q9DBG5, Q3TK05, Q8BKV9, Q9CZK1	Gene names	M6prbp1, Tip47
Domain Architecture	No domain graphic available
Description	Mannose-6-phosphate receptor-binding protein 1 (Cargo selection protein TIP47).

MYH10_MOUSE
θ value	1.38821 (rank : 38)	NC score	0.028173 (rank : 48)
Query Neighborhood Hits	79	Target Neighborhood Hits	1612	Shared Neighborhood Hits	41
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYO1C_MOUSE
θ value	1.38821 (rank : 39)	NC score	0.018815 (rank : 58)
Query Neighborhood Hits	79	Target Neighborhood Hits	63	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WTI7, O08571, O08834, Q9QW54	Gene names	Myo1c
Domain Architecture
Description	Myosin Ic (Myosin I beta) (MMIb).

CKAP4_HUMAN
θ value	1.81305 (rank : 40)	NC score	0.052536 (rank : 23)
Query Neighborhood Hits	79	Target Neighborhood Hits	592	Shared Neighborhood Hits	34
SwissProt Accessions	Q07065, Q504S5, Q53ES6	Gene names	CKAP4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

DESP_HUMAN
θ value	1.81305 (rank : 41)	NC score	0.033628 (rank : 38)
Query Neighborhood Hits	79	Target Neighborhood Hits	1470	Shared Neighborhood Hits	40
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

RAB7L_HUMAN
θ value	1.81305 (rank : 42)	NC score	0.014687 (rank : 66)
Query Neighborhood Hits	79	Target Neighborhood Hits	271	Shared Neighborhood Hits	8
SwissProt Accessions	O14966	Gene names	RAB7L1
Domain Architecture
Description	Ras-related protein Rab-7L1 (Rab-7-like protein 1).

RAB7L_MOUSE
θ value	1.81305 (rank : 43)	NC score	0.014649 (rank : 67)
Query Neighborhood Hits	79	Target Neighborhood Hits	273	Shared Neighborhood Hits	8
SwissProt Accessions	Q91YQ1	Gene names	Rab7l1
Domain Architecture	No domain graphic available
Description	Ras-related protein Rab-7L1 (Rab-7-like protein 1).

MCM8_HUMAN
θ value	2.36792 (rank : 44)	NC score	0.026859 (rank : 50)
Query Neighborhood Hits	79	Target Neighborhood Hits	25	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UJA3, Q495R4, Q495R7, Q86US4, Q969I5	Gene names	MCM8, C20orf154
Domain Architecture
Description	DNA replication licensing factor MCM8 (Minichromosome maintenance 8).

MCM8_MOUSE
θ value	2.36792 (rank : 45)	NC score	0.026993 (rank : 49)
Query Neighborhood Hits	79	Target Neighborhood Hits	38	Shared Neighborhood Hits	5
SwissProt Accessions	Q9CWV1, Q80US2, Q80VI0	Gene names	Mcm8
Domain Architecture	No domain graphic available
Description	DNA replication licensing factor MCM8 (Minichromosome maintenance 8).

FLIP1_HUMAN
θ value	3.0926 (rank : 46)	NC score	0.032384 (rank : 43)
Query Neighborhood Hits	79	Target Neighborhood Hits	1405	Shared Neighborhood Hits	40
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

GUC2F_HUMAN
θ value	3.0926 (rank : 47)	NC score	0.006862 (rank : 77)
Query Neighborhood Hits	79	Target Neighborhood Hits	740	Shared Neighborhood Hits	6
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

MYO1C_HUMAN
θ value	3.0926 (rank : 48)	NC score	0.016480 (rank : 65)
Query Neighborhood Hits	79	Target Neighborhood Hits	65	Shared Neighborhood Hits	7
SwissProt Accessions	O00159	Gene names	MYO1C
Domain Architecture
Description	Myosin Ic (Myosin I beta) (MMI-beta) (MMIb).

KIF3B_HUMAN
θ value	4.03905 (rank : 49)	NC score	0.025789 (rank : 52)
Query Neighborhood Hits	79	Target Neighborhood Hits	540	Shared Neighborhood Hits	35
SwissProt Accessions	O15066	Gene names	KIF3B, KIAA0359
Domain Architecture
Description	Kinesin-like protein KIF3B (Microtubule plus end-directed kinesin motor 3B) (HH0048).

KIF3B_MOUSE
θ value	4.03905 (rank : 50)	NC score	0.024491 (rank : 56)
Query Neighborhood Hits	79	Target Neighborhood Hits	533	Shared Neighborhood Hits	34
SwissProt Accessions	Q61771	Gene names	Kif3b
Domain Architecture
Description	Kinesin-like protein KIF3B (Microtubule plus end-directed kinesin motor 3B).

KMHN1_HUMAN
θ value	4.03905 (rank : 51)	NC score	0.036392 (rank : 34)
Query Neighborhood Hits	79	Target Neighborhood Hits	950	Shared Neighborhood Hits	37
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

MFN1_MOUSE
θ value	4.03905 (rank : 52)	NC score	0.038497 (rank : 33)
Query Neighborhood Hits	79	Target Neighborhood Hits	55	Shared Neighborhood Hits	7
SwissProt Accessions	Q811U4, Q811D5, Q8CEY6, Q99M10, Q9D395	Gene names	Mfn1
Domain Architecture
Description	Transmembrane GTPase MFN1 (EC 3.6.5.-) (Mitofusin-1).

P55G_HUMAN
θ value	4.03905 (rank : 53)	NC score	0.018501 (rank : 59)
Query Neighborhood Hits	79	Target Neighborhood Hits	451	Shared Neighborhood Hits	28
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

SMC2_MOUSE
θ value	4.03905 (rank : 54)	NC score	0.033042 (rank : 39)
Query Neighborhood Hits	79	Target Neighborhood Hits	1131	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CG48, Q61076, Q9CS17, Q9CSD8	Gene names	Smc2l1, Cape, Fin16, Smc2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (XCAP-E homolog) (FGF-inducible protein 16).

EXOC4_HUMAN
θ value	5.27518 (rank : 55)	NC score	0.024518 (rank : 55)
Query Neighborhood Hits	79	Target Neighborhood Hits	72	Shared Neighborhood Hits	8
SwissProt Accessions	Q96A65, Q9C0G4, Q9H9K0, Q9P102	Gene names	EXOC4, KIAA1699, SEC8, SEC8L1
Domain Architecture
Description	Exocyst complex component 4 (Exocyst complex component Sec8).

KI13B_HUMAN
θ value	5.27518 (rank : 56)	NC score	0.022524 (rank : 57)
Query Neighborhood Hits	79	Target Neighborhood Hits	492	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NQT8, O75134, Q9BYJ6	Gene names	KIF13B, GAKIN, KIAA0639
Domain Architecture
Description	Kinesin-like protein KIF13B (Kinesin-like protein GAKIN).

RAB30_HUMAN
θ value	5.27518 (rank : 57)	NC score	0.008193 (rank : 75)
Query Neighborhood Hits	79	Target Neighborhood Hits	274	Shared Neighborhood Hits	8
SwissProt Accessions	Q15771, Q6FGK1, Q96CI8	Gene names	RAB30
Domain Architecture
Description	Ras-related protein Rab-30.

RAB30_MOUSE
θ value	5.27518 (rank : 58)	NC score	0.008193 (rank : 76)
Query Neighborhood Hits	79	Target Neighborhood Hits	274	Shared Neighborhood Hits	8
SwissProt Accessions	Q923S9, Q3UQR3, Q9D3Q6	Gene names	Rab30, Rsb30
Domain Architecture	No domain graphic available
Description	Ras-related protein Rab-30.

SMC2_HUMAN
θ value	5.27518 (rank : 59)	NC score	0.032516 (rank : 42)
Query Neighborhood Hits	79	Target Neighborhood Hits	1405	Shared Neighborhood Hits	42
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

STAM2_HUMAN
θ value	5.27518 (rank : 60)	NC score	0.017077 (rank : 63)
Query Neighborhood Hits	79	Target Neighborhood Hits	288	Shared Neighborhood Hits	7
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

GBP1_HUMAN
θ value	6.88961 (rank : 61)	NC score	0.017895 (rank : 61)
Query Neighborhood Hits	79	Target Neighborhood Hits	339	Shared Neighborhood Hits	23
SwissProt Accessions	P32455	Gene names	GBP1
Domain Architecture
Description	Interferon-induced guanylate-binding protein 1 (GTP-binding protein 1) (Guanine nucleotide-binding protein 1) (GBP-1) (HuGBP-1).

GOGB1_HUMAN
θ value	6.88961 (rank : 62)	NC score	0.032273 (rank : 44)
Query Neighborhood Hits	79	Target Neighborhood Hits	2297	Shared Neighborhood Hits	44
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

K0586_HUMAN
θ value	6.88961 (rank : 63)	NC score	0.034173 (rank : 37)
Query Neighborhood Hits	79	Target Neighborhood Hits	311	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BVV6, O60328	Gene names	KIAA0586
Domain Architecture	No domain graphic available
Description	Protein KIAA0586.

MYH8_HUMAN
θ value	6.88961 (rank : 64)	NC score	0.025532 (rank : 53)
Query Neighborhood Hits	79	Target Neighborhood Hits	1610	Shared Neighborhood Hits	47
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

SYNE2_HUMAN
θ value	6.88961 (rank : 65)	NC score	0.032589 (rank : 41)
Query Neighborhood Hits	79	Target Neighborhood Hits	1323	Shared Neighborhood Hits	43
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

TRIPB_HUMAN
θ value	6.88961 (rank : 66)	NC score	0.032136 (rank : 46)
Query Neighborhood Hits	79	Target Neighborhood Hits	1587	Shared Neighborhood Hits	41
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

ABCB5_HUMAN
θ value	8.99809 (rank : 67)	NC score	0.004719 (rank : 78)
Query Neighborhood Hits	79	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q2M3G0, Q2M3I5, Q5I5Q7, Q5I5Q8, Q6KG50, Q6XFQ5, Q8IXA1	Gene names	ABCB5
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family B member 5 (P-glycoprotein ABCB5) (ABCB5 P-gp).

CR034_MOUSE
θ value	8.99809 (rank : 68)	NC score	0.039474 (rank : 31)
Query Neighborhood Hits	79	Target Neighborhood Hits	643	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CDV0	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34 homolog.

CYLN2_HUMAN
θ value	8.99809 (rank : 69)	NC score	0.041823 (rank : 30)
Query Neighborhood Hits	79	Target Neighborhood Hits	1004	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UDT6, O14527, O43611	Gene names	CYLN2, KIAA0291, WBSCR4, WSCR4
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115) (Williams-Beuren syndrome chromosome region 4 protein).

DMD_MOUSE
θ value	8.99809 (rank : 70)	NC score	0.024592 (rank : 54)
Query Neighborhood Hits	79	Target Neighborhood Hits	1111	Shared Neighborhood Hits	38
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

LAMA2_MOUSE
θ value	8.99809 (rank : 71)	NC score	0.016974 (rank : 64)
Query Neighborhood Hits	79	Target Neighborhood Hits	1198	Shared Neighborhood Hits	32
SwissProt Accessions	Q60675, Q05003, Q64061	Gene names	Lama2
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

PLEK2_HUMAN
θ value	8.99809 (rank : 72)	NC score	0.008312 (rank : 74)
Query Neighborhood Hits	79	Target Neighborhood Hits	101	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

RAB28_HUMAN
θ value	8.99809 (rank : 73)	NC score	0.009009 (rank : 72)
Query Neighborhood Hits	79	Target Neighborhood Hits	261	Shared Neighborhood Hits	8
SwissProt Accessions	P51157, Q8IYR8, Q8NI05	Gene names	RAB28
Domain Architecture
Description	Ras-related protein Rab-28 (Rab-26).

RAB28_MOUSE
θ value	8.99809 (rank : 74)	NC score	0.009187 (rank : 71)
Query Neighborhood Hits	79	Target Neighborhood Hits	266	Shared Neighborhood Hits	8
SwissProt Accessions	Q99KL7	Gene names	Rab28
Domain Architecture
Description	Ras-related protein Rab-28.

RBBP6_MOUSE
θ value	8.99809 (rank : 75)	NC score	0.010588 (rank : 69)
Query Neighborhood Hits	79	Target Neighborhood Hits	1014	Shared Neighborhood Hits	13
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

RHG12_HUMAN
θ value	8.99809 (rank : 76)	NC score	0.004513 (rank : 79)
Query Neighborhood Hits	79	Target Neighborhood Hits	190	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

SYNJ1_HUMAN
θ value	8.99809 (rank : 77)	NC score	0.008570 (rank : 73)
Query Neighborhood Hits	79	Target Neighborhood Hits	498	Shared Neighborhood Hits	5
SwissProt Accessions	O43426, O43425, O94984	Gene names	SYNJ1, KIAA0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

WBP11_HUMAN
θ value	8.99809 (rank : 78)	NC score	0.017661 (rank : 62)
Query Neighborhood Hits	79	Target Neighborhood Hits	354	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

WBP11_MOUSE
θ value	8.99809 (rank : 79)	NC score	0.018260 (rank : 60)
Query Neighborhood Hits	79	Target Neighborhood Hits	362	Shared Neighborhood Hits	8
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

Hits sorted by NC score

OPA1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	79	Target Neighborhood Hits	79	Shared Neighborhood Hits	79
SwissProt Accessions	P58281, Q3ULA5, Q8BKU7, Q8BLL3, Q8BM08, Q8R3J7	Gene names	Opa1
Domain Architecture
Description	Dynamin-like 120 kDa protein, mitochondrial precursor (Optic atrophy protein 1 homolog) (Large GTP-binding protein) (LargeG) [Contains: Dynamin-like 120 kDa protein, form S1].

OPA1_HUMAN
NC score	0.996008 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	79	Target Neighborhood Hits	85	Shared Neighborhood Hits	68
SwissProt Accessions	O60313	Gene names	OPA1, KIAA0567
Domain Architecture
Description	Dynamin-like 120 kDa protein, mitochondrial precursor (Optic atrophy protein 1) [Contains: Dynamin-like 120 kDa protein, form S1].

DNM1L_HUMAN
NC score	0.714856 (rank : 3)	θ value	2.87452e-22 (rank : 7)
Query Neighborhood Hits	79	Target Neighborhood Hits	39	Shared Neighborhood Hits	15
SwissProt Accessions	O00429, O14541, O60709, Q7L6B3, Q8TBT7, Q9BWM1, Q9Y5J2	Gene names	DNM1L, DLP1, DRP1
Domain Architecture	No domain graphic available
Description	Dynamin-1-like protein (EC 3.6.5.5) (Dynamin-like protein) (Dnm1p/Vps1p-like protein) (DVLP) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple) (Dynamin-related protein 1) (Dynamin-like protein 4) (Dynamin-like protein IV) (HdynIV).

DNM1L_MOUSE
NC score	0.713442 (rank : 4)	θ value	8.36355e-22 (rank : 8)
Query Neighborhood Hits	79	Target Neighborhood Hits	28	Shared Neighborhood Hits	14
SwissProt Accessions	Q8K1M6, Q8BNQ5, Q8BQ64, Q8CGD0, Q8K1A1	Gene names	Dnm1l, Drp1
Domain Architecture	No domain graphic available
Description	Dynamin-1-like protein (EC 3.6.5.5) (Dynamin-related protein 1) (Dynamin family member proline-rich carboxyl-terminal domain less) (Dymple).

MX1_HUMAN
NC score	0.705752 (rank : 5)	θ value	1.42661e-21 (rank : 9)
Query Neighborhood Hits	79	Target Neighborhood Hits	62	Shared Neighborhood Hits	17
SwissProt Accessions	P20591	Gene names	MX1
Domain Architecture
Description	Interferon-induced GTP-binding protein Mx1 (Interferon-regulated resistance GTP-binding protein MxA) (Interferon-induced protein p78) (IFI-78K).

MX1_MOUSE
NC score	0.701981 (rank : 6)	θ value	2.69047e-20 (rank : 12)
Query Neighborhood Hits	79	Target Neighborhood Hits	60	Shared Neighborhood Hits	15
SwissProt Accessions	P09922	Gene names	Mx1
Domain Architecture
Description	Interferon-induced GTP-binding protein Mx1 (Influenza resistance protein).

MX2_HUMAN
NC score	0.700123 (rank : 7)	θ value	1.5773e-20 (rank : 11)
Query Neighborhood Hits	79	Target Neighborhood Hits	71	Shared Neighborhood Hits	17
SwissProt Accessions	P20592	Gene names	MX2
Domain Architecture
Description	Interferon-induced GTP-binding protein Mx2 (Interferon-regulated resistance GTP-binding protein MxB) (p78-related protein).

MX2_MOUSE
NC score	0.695956 (rank : 8)	θ value	5.07402e-19 (rank : 13)
Query Neighborhood Hits	79	Target Neighborhood Hits	62	Shared Neighborhood Hits	15
SwissProt Accessions	Q9WVP9, Q922L4	Gene names	Mx2
Domain Architecture	No domain graphic available
Description	Interferon-induced GTP-binding protein Mx2.

DYN2_HUMAN
NC score	0.693121 (rank : 9)	θ value	3.07116e-24 (rank : 3)
Query Neighborhood Hits	79	Target Neighborhood Hits	112	Shared Neighborhood Hits	13
SwissProt Accessions	P50570, Q7Z5S3, Q9UPH4	Gene names	DNM2, DYN2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5).

DYN2_MOUSE
NC score	0.692188 (rank : 10)	θ value	6.84181e-24 (rank : 4)
Query Neighborhood Hits	79	Target Neighborhood Hits	104	Shared Neighborhood Hits	13
SwissProt Accessions	P39054, Q9DBE1	Gene names	Dnm2, Dyn2
Domain Architecture
Description	Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM).

DYN1_MOUSE
NC score	0.688954 (rank : 11)	θ value	2.59989e-23 (rank : 5)
Query Neighborhood Hits	79	Target Neighborhood Hits	168	Shared Neighborhood Hits	19
SwissProt Accessions	P39053, Q61358, Q61359, Q61360, Q8JZZ4, Q9CSY7, Q9QXX1	Gene names	Dnm1, Dnm
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

DYN1_HUMAN
NC score	0.684286 (rank : 12)	θ value	3.39556e-23 (rank : 6)
Query Neighborhood Hits	79	Target Neighborhood Hits	216	Shared Neighborhood Hits	18
SwissProt Accessions	Q05193	Gene names	DNM1, DNM
Domain Architecture
Description	Dynamin-1 (EC 3.6.5.5).

DYN3_HUMAN
NC score	0.682724 (rank : 13)	θ value	1.86321e-21 (rank : 10)
Query Neighborhood Hits	79	Target Neighborhood Hits	158	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UQ16, O14982, O95555, Q5W129, Q9H0P3, Q9H548, Q9NQ68, Q9NQN6	Gene names	DNM3, KIAA0820
Domain Architecture
Description	Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin).

MFN1_HUMAN
NC score	0.088694 (rank : 14)	θ value	0.21417 (rank : 20)
Query Neighborhood Hits	79	Target Neighborhood Hits	71	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IWA4, O15323, O60639, Q9BZB5, Q9NWQ2	Gene names	MFN1
Domain Architecture
Description	Transmembrane GTPase MFN1 (EC 3.6.5.-) (Mitofusin-1) (Fzo homolog).

DOCK2_MOUSE
NC score	0.077892 (rank : 15)	θ value	0.00298849 (rank : 15)
Query Neighborhood Hits	79	Target Neighborhood Hits	104	Shared Neighborhood Hits	8
SwissProt Accessions	Q8C3J5, Q99M79	Gene names	Dock2
Domain Architecture
Description	Dedicator of cytokinesis protein 2 (Hch protein).

TACC3_MOUSE
NC score	0.071958 (rank : 16)	θ value	0.0252991 (rank : 17)
Query Neighborhood Hits	79	Target Neighborhood Hits	607	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JJ11, Q9WVK9	Gene names	Tacc3, Aint
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ARNT-interacting protein).

DOCK2_HUMAN
NC score	0.066394 (rank : 17)	θ value	0.0563607 (rank : 18)
Query Neighborhood Hits	79	Target Neighborhood Hits	90	Shared Neighborhood Hits	7
SwissProt Accessions	Q92608, Q96AK7	Gene names	DOCK2, KIAA0209
Domain Architecture
Description	Dedicator of cytokinesis protein 2.

RBCC1_HUMAN
NC score	0.065982 (rank : 18)	θ value	0.0252991 (rank : 16)
Query Neighborhood Hits	79	Target Neighborhood Hits	1023	Shared Neighborhood Hits	40
SwissProt Accessions	Q8TDY2, Q8WVU9, Q92601	Gene names	RB1CC1, KIAA0203, RBICC
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1.

REST_HUMAN
NC score	0.065801 (rank : 19)	θ value	0.00020696 (rank : 14)
Query Neighborhood Hits	79	Target Neighborhood Hits	1605	Shared Neighborhood Hits	46
SwissProt Accessions	P30622	Gene names	RSN, CYLN1
Domain Architecture
Description	Restin (Cytoplasmic linker protein 170 alpha-2) (CLIP-170) (Reed- Sternberg intermediate filament-associated protein) (Cytoplasmic linker protein 1).

PALB2_HUMAN
NC score	0.061978 (rank : 20)	θ value	0.279714 (rank : 21)
Query Neighborhood Hits	79	Target Neighborhood Hits	117	Shared Neighborhood Hits	6
SwissProt Accessions	Q86YC2, Q8N7Y6, Q8ND31, Q9H6W1	Gene names	PALB2
Domain Architecture	No domain graphic available
Description	Partner and localizer of BRCA2.

RBCC1_MOUSE
NC score	0.057130 (rank : 21)	θ value	0.813845 (rank : 28)
Query Neighborhood Hits	79	Target Neighborhood Hits	1048	Shared Neighborhood Hits	39
SwissProt Accessions	Q9ESK9, Q3TXX2, Q61384, Q8BRY9, Q9JK14	Gene names	Rb1cc1, Cc1, Kiaa0203
Domain Architecture	No domain graphic available
Description	RB1-inducible coiled-coil protein 1 (Coiled-coil-forming protein 1) (LaXp180 protein).

CKAP4_MOUSE
NC score	0.053752 (rank : 22)	θ value	1.38821 (rank : 32)
Query Neighborhood Hits	79	Target Neighborhood Hits	596	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BMK4, Q8BTK8, Q8R3F2	Gene names	Ckap4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

CKAP4_HUMAN
NC score	0.052536 (rank : 23)	θ value	1.81305 (rank : 40)
Query Neighborhood Hits	79	Target Neighborhood Hits	592	Shared Neighborhood Hits	34
SwissProt Accessions	Q07065, Q504S5, Q53ES6	Gene names	CKAP4
Domain Architecture	No domain graphic available
Description	Cytoskeleton-associated protein 4 (63 kDa membrane protein) (p63).

REST_MOUSE
NC score	0.051374 (rank : 24)	θ value	0.365318 (rank : 24)
Query Neighborhood Hits	79	Target Neighborhood Hits	1506	Shared Neighborhood Hits	41
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

DYNA_HUMAN
NC score	0.047019 (rank : 25)	θ value	1.06291 (rank : 30)
Query Neighborhood Hits	79	Target Neighborhood Hits	1194	Shared Neighborhood Hits	40
SwissProt Accessions	Q14203, O95296, Q9BRM9, Q9UIU1, Q9UIU2	Gene names	DCTN1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued) (p135).

PKHC1_HUMAN
NC score	0.046036 (rank : 26)	θ value	0.62314 (rank : 27)
Query Neighborhood Hits	79	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	Q96AC1, Q14840, Q86TY7	Gene names	PLEKHC1, KIND2, MIG2
Domain Architecture
Description	Pleckstrin homology domain-containing family C member 1 (Kindlin-2) (Mitogen-inducible gene 2 protein) (Mig-2).

DYNA_MOUSE
NC score	0.045624 (rank : 27)	θ value	1.38821 (rank : 34)
Query Neighborhood Hits	79	Target Neighborhood Hits	1084	Shared Neighborhood Hits	39
SwissProt Accessions	O08788	Gene names	Dctn1
Domain Architecture
Description	Dynactin-1 (150 kDa dynein-associated polypeptide) (DP-150) (DAP-150) (p150-glued).

IFT74_MOUSE
NC score	0.043642 (rank : 28)	θ value	1.38821 (rank : 35)
Query Neighborhood Hits	79	Target Neighborhood Hits	939	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BKE9, Q80ZI3, Q9CSY1, Q9CUS0, Q9D9T5	Gene names	Ift74, Ccdc2, Cmg1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 74 homolog (Coiled-coil domain-containing protein 2) (Capillary morphogenesis protein 1) (CMG-1).

PKHC1_MOUSE
NC score	0.042845 (rank : 29)	θ value	1.06291 (rank : 31)
Query Neighborhood Hits	79	Target Neighborhood Hits	28	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CIB5, Q8C542, Q8K035	Gene names	Plekhc1
Domain Architecture
Description	Pleckstrin homology domain-containing family C member 1.

CYLN2_HUMAN
NC score	0.041823 (rank : 30)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	79	Target Neighborhood Hits	1004	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UDT6, O14527, O43611	Gene names	CYLN2, KIAA0291, WBSCR4, WSCR4
Domain Architecture	No domain graphic available
Description	Cytoplasmic linker protein 2 (Cytoplasmic linker protein 115) (CLIP- 115) (Williams-Beuren syndrome chromosome region 4 protein).

CR034_MOUSE
NC score	0.039474 (rank : 31)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	79	Target Neighborhood Hits	643	Shared Neighborhood Hits	34
SwissProt Accessions	Q8CDV0	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34 homolog.

GOGA4_HUMAN
NC score	0.039013 (rank : 32)	θ value	0.47712 (rank : 26)
Query Neighborhood Hits	79	Target Neighborhood Hits	2034	Shared Neighborhood Hits	44
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

MFN1_MOUSE
NC score	0.038497 (rank : 33)	θ value	4.03905 (rank : 52)
Query Neighborhood Hits	79	Target Neighborhood Hits	55	Shared Neighborhood Hits	7
SwissProt Accessions	Q811U4, Q811D5, Q8CEY6, Q99M10, Q9D395	Gene names	Mfn1
Domain Architecture
Description	Transmembrane GTPase MFN1 (EC 3.6.5.-) (Mitofusin-1).

KMHN1_HUMAN
NC score	0.036392 (rank : 34)	θ value	4.03905 (rank : 51)
Query Neighborhood Hits	79	Target Neighborhood Hits	950	Shared Neighborhood Hits	37
SwissProt Accessions	Q8TBZ0, Q86YI9, Q8N7W0	Gene names	KMHN1
Domain Architecture	No domain graphic available
Description	Cancer/testis antigen KM-HN-1.

CENPE_HUMAN
NC score	0.035849 (rank : 35)	θ value	1.06291 (rank : 29)
Query Neighborhood Hits	79	Target Neighborhood Hits	2060	Shared Neighborhood Hits	47
SwissProt Accessions	Q02224	Gene names	CENPE
Domain Architecture
Description	Centromeric protein E (CENP-E).

CROCC_HUMAN
NC score	0.035370 (rank : 36)	θ value	1.38821 (rank : 33)
Query Neighborhood Hits	79	Target Neighborhood Hits	1409	Shared Neighborhood Hits	40
SwissProt Accessions	Q5TZA2, Q2VHY3, Q66GT7, Q7Z2L4, Q7Z5D7	Gene names	CROCC, KIAA0445
Domain Architecture	No domain graphic available
Description	Rootletin (Ciliary rootlet coiled-coil protein).

K0586_HUMAN
NC score	0.034173 (rank : 37)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	79	Target Neighborhood Hits	311	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BVV6, O60328	Gene names	KIAA0586
Domain Architecture	No domain graphic available
Description	Protein KIAA0586.

DESP_HUMAN
NC score	0.033628 (rank : 38)	θ value	1.81305 (rank : 41)
Query Neighborhood Hits	79	Target Neighborhood Hits	1470	Shared Neighborhood Hits	40
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

SMC2_MOUSE
NC score	0.033042 (rank : 39)	θ value	4.03905 (rank : 54)
Query Neighborhood Hits	79	Target Neighborhood Hits	1131	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CG48, Q61076, Q9CS17, Q9CSD8	Gene names	Smc2l1, Cape, Fin16, Smc2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (XCAP-E homolog) (FGF-inducible protein 16).

M6PBP_MOUSE
NC score	0.032888 (rank : 40)	θ value	1.38821 (rank : 37)
Query Neighborhood Hits	79	Target Neighborhood Hits	91	Shared Neighborhood Hits	9
SwissProt Accessions	Q9DBG5, Q3TK05, Q8BKV9, Q9CZK1	Gene names	M6prbp1, Tip47
Domain Architecture	No domain graphic available
Description	Mannose-6-phosphate receptor-binding protein 1 (Cargo selection protein TIP47).

SYNE2_HUMAN
NC score	0.032589 (rank : 41)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	79	Target Neighborhood Hits	1323	Shared Neighborhood Hits	43
SwissProt Accessions	Q8WXH0, Q8N1S3, Q8NF49, Q8TER7, Q8WWW3, Q8WWW4, Q8WWW5, Q8WXH1, Q9NU50, Q9UFQ4, Q9Y2L4, Q9Y4R1	Gene names	SYNE2, KIAA1011, NUA
Domain Architecture
Description	Nesprin-2 (Nuclear envelope spectrin repeat protein 2) (Syne-2) (Synaptic nuclear envelope protein 2) (Nucleus and actin connecting element protein) (Protein NUANCE).

SMC2_HUMAN
NC score	0.032516 (rank : 42)	θ value	5.27518 (rank : 59)
Query Neighborhood Hits	79	Target Neighborhood Hits	1405	Shared Neighborhood Hits	42
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

FLIP1_HUMAN
NC score	0.032384 (rank : 43)	θ value	3.0926 (rank : 46)
Query Neighborhood Hits	79	Target Neighborhood Hits	1405	Shared Neighborhood Hits	40
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

GOGB1_HUMAN
NC score	0.032273 (rank : 44)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	79	Target Neighborhood Hits	2297	Shared Neighborhood Hits	44
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

ANR26_MOUSE
NC score	0.032204 (rank : 45)	θ value	0.47712 (rank : 25)
Query Neighborhood Hits	79	Target Neighborhood Hits	1554	Shared Neighborhood Hits	41
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

TRIPB_HUMAN
NC score	0.032136 (rank : 46)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	79	Target Neighborhood Hits	1587	Shared Neighborhood Hits	41
SwissProt Accessions	Q15643, O14689, O15154, O95949	Gene names	TRIP11, CEV14
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 11 (TRIP-11) (Golgi-associated microtubule-binding protein 210) (GMAP-210) (Trip230) (Clonal evolution-related gene on chromosome 14).

ITSN2_MOUSE
NC score	0.030867 (rank : 47)	θ value	0.365318 (rank : 23)
Query Neighborhood Hits	79	Target Neighborhood Hits	1371	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

MYH10_MOUSE
NC score	0.028173 (rank : 48)	θ value	1.38821 (rank : 38)
Query Neighborhood Hits	79	Target Neighborhood Hits	1612	Shared Neighborhood Hits	41
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MCM8_MOUSE
NC score	0.026993 (rank : 49)	θ value	2.36792 (rank : 45)
Query Neighborhood Hits	79	Target Neighborhood Hits	38	Shared Neighborhood Hits	5
SwissProt Accessions	Q9CWV1, Q80US2, Q80VI0	Gene names	Mcm8
Domain Architecture	No domain graphic available
Description	DNA replication licensing factor MCM8 (Minichromosome maintenance 8).

MCM8_HUMAN
NC score	0.026859 (rank : 50)	θ value	2.36792 (rank : 44)
Query Neighborhood Hits	79	Target Neighborhood Hits	25	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UJA3, Q495R4, Q495R7, Q86US4, Q969I5	Gene names	MCM8, C20orf154
Domain Architecture
Description	DNA replication licensing factor MCM8 (Minichromosome maintenance 8).

K2C6G_MOUSE
NC score	0.026236 (rank : 51)	θ value	0.125558 (rank : 19)
Query Neighborhood Hits	79	Target Neighborhood Hits	452	Shared Neighborhood Hits	28
SwissProt Accessions	Q9R0H5, Q7TPF3, Q9D0X6	Gene names	Krt6g, K6irs1, Krt2-6g
Domain Architecture	No domain graphic available
Description	Keratin, type II cytoskeletal 6G (Cytokeratin-6G) (CK 6G) (K6g keratin) (Keratin-K6irs) (mK6irs1/Krt2-6g).

KIF3B_HUMAN
NC score	0.025789 (rank : 52)	θ value	4.03905 (rank : 49)
Query Neighborhood Hits	79	Target Neighborhood Hits	540	Shared Neighborhood Hits	35
SwissProt Accessions	O15066	Gene names	KIF3B, KIAA0359
Domain Architecture
Description	Kinesin-like protein KIF3B (Microtubule plus end-directed kinesin motor 3B) (HH0048).

MYH8_HUMAN
NC score	0.025532 (rank : 53)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	79	Target Neighborhood Hits	1610	Shared Neighborhood Hits	47
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

DMD_MOUSE
NC score	0.024592 (rank : 54)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	79	Target Neighborhood Hits	1111	Shared Neighborhood Hits	38
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

EXOC4_HUMAN
NC score	0.024518 (rank : 55)	θ value	5.27518 (rank : 55)
Query Neighborhood Hits	79	Target Neighborhood Hits	72	Shared Neighborhood Hits	8
SwissProt Accessions	Q96A65, Q9C0G4, Q9H9K0, Q9P102	Gene names	EXOC4, KIAA1699, SEC8, SEC8L1
Domain Architecture
Description	Exocyst complex component 4 (Exocyst complex component Sec8).

KIF3B_MOUSE
NC score	0.024491 (rank : 56)	θ value	4.03905 (rank : 50)
Query Neighborhood Hits	79	Target Neighborhood Hits	533	Shared Neighborhood Hits	34
SwissProt Accessions	Q61771	Gene names	Kif3b
Domain Architecture
Description	Kinesin-like protein KIF3B (Microtubule plus end-directed kinesin motor 3B).

KI13B_HUMAN
NC score	0.022524 (rank : 57)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	79	Target Neighborhood Hits	492	Shared Neighborhood Hits	27
SwissProt Accessions	Q9NQT8, O75134, Q9BYJ6	Gene names	KIF13B, GAKIN, KIAA0639
Domain Architecture
Description	Kinesin-like protein KIF13B (Kinesin-like protein GAKIN).

MYO1C_MOUSE
NC score	0.018815 (rank : 58)	θ value	1.38821 (rank : 39)
Query Neighborhood Hits	79	Target Neighborhood Hits	63	Shared Neighborhood Hits	6
SwissProt Accessions	Q9WTI7, O08571, O08834, Q9QW54	Gene names	Myo1c
Domain Architecture
Description	Myosin Ic (Myosin I beta) (MMIb).

P55G_HUMAN
NC score	0.018501 (rank : 59)	θ value	4.03905 (rank : 53)
Query Neighborhood Hits	79	Target Neighborhood Hits	451	Shared Neighborhood Hits	28
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

WBP11_MOUSE
NC score	0.018260 (rank : 60)	θ value	8.99809 (rank : 79)
Query Neighborhood Hits	79	Target Neighborhood Hits	362	Shared Neighborhood Hits	8
SwissProt Accessions	Q923D5, O88539, Q3UMD8, Q8VDI0	Gene names	Wbp11
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11).

GBP1_HUMAN
NC score	0.017895 (rank : 61)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	79	Target Neighborhood Hits	339	Shared Neighborhood Hits	23
SwissProt Accessions	P32455	Gene names	GBP1
Domain Architecture
Description	Interferon-induced guanylate-binding protein 1 (GTP-binding protein 1) (Guanine nucleotide-binding protein 1) (GBP-1) (HuGBP-1).

WBP11_HUMAN
NC score	0.017661 (rank : 62)	θ value	8.99809 (rank : 78)
Query Neighborhood Hits	79	Target Neighborhood Hits	354	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Y2W2, Q96AY8	Gene names	WBP11, NPWBP, SNP70
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 11 (WBP-11) (SH3 domain-binding protein SNP70) (Npw38-binding protein) (NpwBP).

STAM2_HUMAN
NC score	0.017077 (rank : 63)	θ value	5.27518 (rank : 60)
Query Neighborhood Hits	79	Target Neighborhood Hits	288	Shared Neighborhood Hits	7
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

LAMA2_MOUSE
NC score	0.016974 (rank : 64)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	79	Target Neighborhood Hits	1198	Shared Neighborhood Hits	32
SwissProt Accessions	Q60675, Q05003, Q64061	Gene names	Lama2
Domain Architecture
Description	Laminin alpha-2 chain precursor (Laminin M chain) (Merosin heavy chain).

MYO1C_HUMAN
NC score	0.016480 (rank : 65)	θ value	3.0926 (rank : 48)
Query Neighborhood Hits	79	Target Neighborhood Hits	65	Shared Neighborhood Hits	7
SwissProt Accessions	O00159	Gene names	MYO1C
Domain Architecture
Description	Myosin Ic (Myosin I beta) (MMI-beta) (MMIb).

RAB7L_HUMAN
NC score	0.014687 (rank : 66)	θ value	1.81305 (rank : 42)
Query Neighborhood Hits	79	Target Neighborhood Hits	271	Shared Neighborhood Hits	8
SwissProt Accessions	O14966	Gene names	RAB7L1
Domain Architecture
Description	Ras-related protein Rab-7L1 (Rab-7-like protein 1).

RAB7L_MOUSE
NC score	0.014649 (rank : 67)	θ value	1.81305 (rank : 43)
Query Neighborhood Hits	79	Target Neighborhood Hits	273	Shared Neighborhood Hits	8
SwissProt Accessions	Q91YQ1	Gene names	Rab7l1
Domain Architecture	No domain graphic available
Description	Ras-related protein Rab-7L1 (Rab-7-like protein 1).

LAMC3_HUMAN
NC score	0.013948 (rank : 68)	θ value	1.38821 (rank : 36)
Query Neighborhood Hits	79	Target Neighborhood Hits	588	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Y6N6	Gene names	LAMC3
Domain Architecture
Description	Laminin gamma-3 chain precursor (Laminin 12 gamma 3 subunit).

RBBP6_MOUSE
NC score	0.010588 (rank : 69)	θ value	8.99809 (rank : 75)
Query Neighborhood Hits	79	Target Neighborhood Hits	1014	Shared Neighborhood Hits	13
SwissProt Accessions	P97868, P70287, Q3TTR9, Q3TUM7, Q3UMP7, Q4U217, Q7TT06, Q8BNY8, Q8R399	Gene names	Rbbp6, P2pr, Pact
Domain Architecture	No domain graphic available
Description	Retinoblastoma-binding protein 6 (p53-associated cellular protein of testis) (Proliferation potential-related protein) (Protein P2P-R).

FER_HUMAN
NC score	0.009538 (rank : 70)	θ value	0.365318 (rank : 22)
Query Neighborhood Hits	79	Target Neighborhood Hits	1278	Shared Neighborhood Hits	31
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

RAB28_MOUSE
NC score	0.009187 (rank : 71)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	79	Target Neighborhood Hits	266	Shared Neighborhood Hits	8
SwissProt Accessions	Q99KL7	Gene names	Rab28
Domain Architecture
Description	Ras-related protein Rab-28.

RAB28_HUMAN
NC score	0.009009 (rank : 72)	θ value	8.99809 (rank : 73)
Query Neighborhood Hits	79	Target Neighborhood Hits	261	Shared Neighborhood Hits	8
SwissProt Accessions	P51157, Q8IYR8, Q8NI05	Gene names	RAB28
Domain Architecture
Description	Ras-related protein Rab-28 (Rab-26).

SYNJ1_HUMAN
NC score	0.008570 (rank : 73)	θ value	8.99809 (rank : 77)
Query Neighborhood Hits	79	Target Neighborhood Hits	498	Shared Neighborhood Hits	5
SwissProt Accessions	O43426, O43425, O94984	Gene names	SYNJ1, KIAA0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

PLEK2_HUMAN
NC score	0.008312 (rank : 74)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	79	Target Neighborhood Hits	101	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

RAB30_HUMAN
NC score	0.008193 (rank : 75)	θ value	5.27518 (rank : 57)
Query Neighborhood Hits	79	Target Neighborhood Hits	274	Shared Neighborhood Hits	8
SwissProt Accessions	Q15771, Q6FGK1, Q96CI8	Gene names	RAB30
Domain Architecture
Description	Ras-related protein Rab-30.

RAB30_MOUSE
NC score	0.008193 (rank : 76)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	79	Target Neighborhood Hits	274	Shared Neighborhood Hits	8
SwissProt Accessions	Q923S9, Q3UQR3, Q9D3Q6	Gene names	Rab30, Rsb30
Domain Architecture	No domain graphic available
Description	Ras-related protein Rab-30.

GUC2F_HUMAN
NC score	0.006862 (rank : 77)	θ value	3.0926 (rank : 47)
Query Neighborhood Hits	79	Target Neighborhood Hits	740	Shared Neighborhood Hits	6
SwissProt Accessions	P51841, Q9UJF1	Gene names	GUCY2F, GUC2F, RETGC2
Domain Architecture
Description	Retinal guanylyl cyclase 2 precursor (EC 4.6.1.2) (Guanylate cyclase 2F, retinal) (RETGC-2) (Rod outer segment membrane guanylate cyclase 2) (ROS-GC2) (Guanylate cyclase F) (GC-F).

ABCB5_HUMAN
NC score	0.004719 (rank : 78)	θ value	8.99809 (rank : 67)
Query Neighborhood Hits	79	Target Neighborhood Hits	102	Shared Neighborhood Hits	5
SwissProt Accessions	Q2M3G0, Q2M3I5, Q5I5Q7, Q5I5Q8, Q6KG50, Q6XFQ5, Q8IXA1	Gene names	ABCB5
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family B member 5 (P-glycoprotein ABCB5) (ABCB5 P-gp).

RHG12_HUMAN
NC score	0.004513 (rank : 79)	θ value	8.99809 (rank : 76)
Query Neighborhood Hits	79	Target Neighborhood Hits	190	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.