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Network neighborhood for query Sequence : PUR2_MOUSE

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PUR2_MOUSE
SwissProt Accessions	Q64737, Q6NS48	Gene names	Gart
Domain Architecture
Description	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PUR2_HUMAN
θ value	0 (rank : 1)	NC score	0.996569 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	21	Shared Neighborhood Hits	11
SwissProt Accessions	P22102	Gene names	GART, PRGS
Domain Architecture
Description	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)].

PUR2_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q64737, Q6NS48	Gene names	Gart
Domain Architecture
Description	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)].

FMT_HUMAN
θ value	2.44474e-05 (rank : 3)	NC score	0.310260 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	9	Shared Neighborhood Hits	6
SwissProt Accessions	Q96DP5	Gene names	MTFMT, FMT, FMT1
Domain Architecture
Description	Methionyl-tRNA formyltransferase, mitochondrial precursor (EC 2.1.2.9) (MtFMT).

FMT_MOUSE
θ value	2.44474e-05 (rank : 4)	NC score	0.309687 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	8	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D799, Q8VE89	Gene names	Mtfmt, Fmt
Domain Architecture
Description	Methionyl-tRNA formyltransferase, mitochondrial precursor (EC 2.1.2.9) (MtFMT).

FTHFD_HUMAN
θ value	7.1131e-05 (rank : 5)	NC score	0.120609 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	38	Shared Neighborhood Hits	6
SwissProt Accessions	O75891, Q68CS1	Gene names	ALDH1L1, FTHFD
Domain Architecture
Description	10-formyltetrahydrofolate dehydrogenase (EC 1.5.1.6) (10-FTHFDH) (Aldehyde dehydrogenase 1 family member L1).

FTHFD_MOUSE
θ value	9.29e-05 (rank : 6)	NC score	0.125000 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R0Y6	Gene names	Aldh1l1, Fthfd
Domain Architecture
Description	10-formyltetrahydrofolate dehydrogenase (EC 1.5.1.6) (10-FTHFDH) (Aldehyde dehydrogenase 1 family member L1).

CPSM_HUMAN
θ value	0.0113563 (rank : 7)	NC score	0.119406 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	27	Shared Neighborhood Hits	7
SwissProt Accessions	P31327, O43774, Q7Z5I5	Gene names	CPS1
Domain Architecture
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

CPSM_MOUSE
θ value	0.0431538 (rank : 8)	NC score	0.102666 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	32	Shared Neighborhood Hits	7
SwissProt Accessions	Q8C196, Q6NX75	Gene names	Cps1
Domain Architecture	No domain graphic available
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

ICAL_MOUSE
θ value	3.0926 (rank : 9)	NC score	0.025419 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	178	Shared Neighborhood Hits	2
SwissProt Accessions	P51125, Q9EQV4, Q9EQV5, Q9QXQ3, Q9QXQ4, Q9R0N1	Gene names	Cast
Domain Architecture
Description	Calpastatin (Calpain inhibitor).

ANKS6_MOUSE
θ value	5.27518 (rank : 10)	NC score	0.006698 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	435	Shared Neighborhood Hits	2
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

MCCA_MOUSE
θ value	5.27518 (rank : 11)	NC score	0.035356 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	7
SwissProt Accessions	Q99MR8, Q3TGU0, Q9D8R2	Gene names	Mccc1, Mcca
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

PGBM_HUMAN
θ value	5.27518 (rank : 12)	NC score	0.003450 (rank : 19)
Query Neighborhood Hits	18	Target Neighborhood Hits	1113	Shared Neighborhood Hits	2
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).

TRPV2_MOUSE
θ value	5.27518 (rank : 13)	NC score	0.010536 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	111	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WTR1, Q99K71	Gene names	Trpv2, Grc
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Growth factor-regulated calcium channel) (GRC).

PCCA_HUMAN
θ value	6.88961 (rank : 14)	NC score	0.034090 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	22	Shared Neighborhood Hits	7
SwissProt Accessions	P05165, Q15979	Gene names	PCCA
Domain Architecture
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

AT2C1_HUMAN
θ value	8.99809 (rank : 15)	NC score	0.004874 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	62	Shared Neighborhood Hits	2
SwissProt Accessions	P98194, O76005, Q86V72, Q86V73, Q8N6V1, Q8NCJ7	Gene names	ATP2C1, KIAA1347, PMR1L
Domain Architecture
Description	Calcium-transporting ATPase type 2C member 1 (EC 3.6.3.8) (ATPase 2C1) (ATP-dependent Ca(2+) pump PMR1).

DOCK9_HUMAN
θ value	8.99809 (rank : 16)	NC score	0.007807 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BZ29, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4	Gene names	DOCK9, KIAA1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

MCCA_HUMAN
θ value	8.99809 (rank : 17)	NC score	0.043002 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	Q96RQ3, Q59ES4, Q9H959, Q9NS97	Gene names	MCCC1, MCCA
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

SUGT1_MOUSE
θ value	8.99809 (rank : 18)	NC score	0.012812 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	73	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CX34, Q3UF88, Q9CRE7, Q9D8M6	Gene names	Sugt1
Domain Architecture
Description	Suppressor of G2 allele of SKP1 homolog.

PYR1_HUMAN
θ value	θ > 10 (rank : 19)	NC score	0.070447 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	119	Shared Neighborhood Hits	6
SwissProt Accessions	P27708, Q6P0Q0	Gene names	CAD
Domain Architecture	No domain graphic available
Description	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)].

Hits sorted by NC score

PUR2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q64737, Q6NS48	Gene names	Gart
Domain Architecture
Description	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)].

PUR2_HUMAN
NC score	0.996569 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	21	Shared Neighborhood Hits	11
SwissProt Accessions	P22102	Gene names	GART, PRGS
Domain Architecture
Description	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)].

FMT_HUMAN
NC score	0.310260 (rank : 3)	θ value	2.44474e-05 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	9	Shared Neighborhood Hits	6
SwissProt Accessions	Q96DP5	Gene names	MTFMT, FMT, FMT1
Domain Architecture
Description	Methionyl-tRNA formyltransferase, mitochondrial precursor (EC 2.1.2.9) (MtFMT).

FMT_MOUSE
NC score	0.309687 (rank : 4)	θ value	2.44474e-05 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	8	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D799, Q8VE89	Gene names	Mtfmt, Fmt
Domain Architecture
Description	Methionyl-tRNA formyltransferase, mitochondrial precursor (EC 2.1.2.9) (MtFMT).

FTHFD_MOUSE
NC score	0.125000 (rank : 5)	θ value	9.29e-05 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R0Y6	Gene names	Aldh1l1, Fthfd
Domain Architecture
Description	10-formyltetrahydrofolate dehydrogenase (EC 1.5.1.6) (10-FTHFDH) (Aldehyde dehydrogenase 1 family member L1).

FTHFD_HUMAN
NC score	0.120609 (rank : 6)	θ value	7.1131e-05 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	38	Shared Neighborhood Hits	6
SwissProt Accessions	O75891, Q68CS1	Gene names	ALDH1L1, FTHFD
Domain Architecture
Description	10-formyltetrahydrofolate dehydrogenase (EC 1.5.1.6) (10-FTHFDH) (Aldehyde dehydrogenase 1 family member L1).

CPSM_HUMAN
NC score	0.119406 (rank : 7)	θ value	0.0113563 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	27	Shared Neighborhood Hits	7
SwissProt Accessions	P31327, O43774, Q7Z5I5	Gene names	CPS1
Domain Architecture
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

CPSM_MOUSE
NC score	0.102666 (rank : 8)	θ value	0.0431538 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	32	Shared Neighborhood Hits	7
SwissProt Accessions	Q8C196, Q6NX75	Gene names	Cps1
Domain Architecture	No domain graphic available
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

PYR1_HUMAN
NC score	0.070447 (rank : 9)	θ value	θ > 10 (rank : 19)
Query Neighborhood Hits	18	Target Neighborhood Hits	119	Shared Neighborhood Hits	6
SwissProt Accessions	P27708, Q6P0Q0	Gene names	CAD
Domain Architecture	No domain graphic available
Description	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)].

MCCA_HUMAN
NC score	0.043002 (rank : 10)	θ value	8.99809 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	Q96RQ3, Q59ES4, Q9H959, Q9NS97	Gene names	MCCC1, MCCA
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

MCCA_MOUSE
NC score	0.035356 (rank : 11)	θ value	5.27518 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	7
SwissProt Accessions	Q99MR8, Q3TGU0, Q9D8R2	Gene names	Mccc1, Mcca
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

PCCA_HUMAN
NC score	0.034090 (rank : 12)	θ value	6.88961 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	22	Shared Neighborhood Hits	7
SwissProt Accessions	P05165, Q15979	Gene names	PCCA
Domain Architecture
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

ICAL_MOUSE
NC score	0.025419 (rank : 13)	θ value	3.0926 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	178	Shared Neighborhood Hits	2
SwissProt Accessions	P51125, Q9EQV4, Q9EQV5, Q9QXQ3, Q9QXQ4, Q9R0N1	Gene names	Cast
Domain Architecture
Description	Calpastatin (Calpain inhibitor).

SUGT1_MOUSE
NC score	0.012812 (rank : 14)	θ value	8.99809 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	73	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CX34, Q3UF88, Q9CRE7, Q9D8M6	Gene names	Sugt1
Domain Architecture
Description	Suppressor of G2 allele of SKP1 homolog.

TRPV2_MOUSE
NC score	0.010536 (rank : 15)	θ value	5.27518 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	111	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WTR1, Q99K71	Gene names	Trpv2, Grc
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Growth factor-regulated calcium channel) (GRC).

DOCK9_HUMAN
NC score	0.007807 (rank : 16)	θ value	8.99809 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BZ29, Q5JUD4, Q5JUD6, Q5T2Q1, Q5TAN8, Q9BZ25, Q9BZ26, Q9BZ27, Q9BZ28, Q9UPU4	Gene names	DOCK9, KIAA1058
Domain Architecture
Description	Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin 1).

ANKS6_MOUSE
NC score	0.006698 (rank : 17)	θ value	5.27518 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	435	Shared Neighborhood Hits	2
SwissProt Accessions	Q6GQX6	Gene names	Anks6, Samd6
Domain Architecture	No domain graphic available
Description	Ankyrin repeat and SAM domain-containing protein 6 (Sterile alpha motif domain-containing protein 6).

AT2C1_HUMAN
NC score	0.004874 (rank : 18)	θ value	8.99809 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	62	Shared Neighborhood Hits	2
SwissProt Accessions	P98194, O76005, Q86V72, Q86V73, Q8N6V1, Q8NCJ7	Gene names	ATP2C1, KIAA1347, PMR1L
Domain Architecture
Description	Calcium-transporting ATPase type 2C member 1 (EC 3.6.3.8) (ATPase 2C1) (ATP-dependent Ca(2+) pump PMR1).

PGBM_HUMAN
NC score	0.003450 (rank : 19)	θ value	5.27518 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	1113	Shared Neighborhood Hits	2
SwissProt Accessions	P98160, Q16287, Q9H3V5	Gene names	HSPG2
Domain Architecture
Description	Basement membrane-specific heparan sulfate proteoglycan core protein precursor (HSPG) (Perlecan) (PLC).