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Network neighborhood for query Sequence : CPSM_MOUSE

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CPSM_MOUSE
SwissProt Accessions	Q8C196, Q6NX75	Gene names	Cps1
Domain Architecture	No domain graphic available
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CPSM_HUMAN
θ value	0 (rank : 1)	NC score	0.998408 (rank : 2)
Query Neighborhood Hits	32	Target Neighborhood Hits	27	Shared Neighborhood Hits	21
SwissProt Accessions	P31327, O43774, Q7Z5I5	Gene names	CPS1
Domain Architecture
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

CPSM_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	32	Target Neighborhood Hits	32	Shared Neighborhood Hits	32
SwissProt Accessions	Q8C196, Q6NX75	Gene names	Cps1
Domain Architecture	No domain graphic available
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

PYR1_HUMAN
θ value	0 (rank : 3)	NC score	0.917954 (rank : 3)
Query Neighborhood Hits	32	Target Neighborhood Hits	119	Shared Neighborhood Hits	13
SwissProt Accessions	P27708, Q6P0Q0	Gene names	CAD
Domain Architecture	No domain graphic available
Description	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)].

COA1_HUMAN
θ value	6.64225e-11 (rank : 4)	NC score	0.396681 (rank : 9)
Query Neighborhood Hits	32	Target Neighborhood Hits	49	Shared Neighborhood Hits	11
SwissProt Accessions	Q13085	Gene names	ACACA, ACAC, ACC1, ACCA
Domain Architecture
Description	Acetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)].

MCCA_HUMAN
θ value	1.47974e-10 (rank : 5)	NC score	0.414289 (rank : 4)
Query Neighborhood Hits	32	Target Neighborhood Hits	26	Shared Neighborhood Hits	13
SwissProt Accessions	Q96RQ3, Q59ES4, Q9H959, Q9NS97	Gene names	MCCC1, MCCA
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

PYC_MOUSE
θ value	9.59137e-10 (rank : 6)	NC score	0.410544 (rank : 5)
Query Neighborhood Hits	32	Target Neighborhood Hits	25	Shared Neighborhood Hits	11
SwissProt Accessions	Q05920	Gene names	Pc, Pcx
Domain Architecture
Description	Pyruvate carboxylase, mitochondrial precursor (EC 6.4.1.1) (Pyruvic carboxylase) (PCB).

MCCA_MOUSE
θ value	3.64472e-09 (rank : 7)	NC score	0.391450 (rank : 10)
Query Neighborhood Hits	32	Target Neighborhood Hits	18	Shared Neighborhood Hits	13
SwissProt Accessions	Q99MR8, Q3TGU0, Q9D8R2	Gene names	Mccc1, Mcca
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

PYC_HUMAN
θ value	8.11959e-09 (rank : 8)	NC score	0.404860 (rank : 6)
Query Neighborhood Hits	32	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	P11498, Q16705	Gene names	PC
Domain Architecture
Description	Pyruvate carboxylase, mitochondrial precursor (EC 6.4.1.1) (Pyruvic carboxylase) (PCB).

PCCA_MOUSE
θ value	8.97725e-08 (rank : 9)	NC score	0.400762 (rank : 7)
Query Neighborhood Hits	32	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	Q91ZA3, Q80VU5, Q922N3	Gene names	Pcca
Domain Architecture	No domain graphic available
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

PCCA_HUMAN
θ value	1.99992e-07 (rank : 10)	NC score	0.399047 (rank : 8)
Query Neighborhood Hits	32	Target Neighborhood Hits	22	Shared Neighborhood Hits	13
SwissProt Accessions	P05165, Q15979	Gene names	PCCA
Domain Architecture
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

COA2_HUMAN
θ value	1.43324e-05 (rank : 11)	NC score	0.344981 (rank : 11)
Query Neighborhood Hits	32	Target Neighborhood Hits	184	Shared Neighborhood Hits	11
SwissProt Accessions	O00763, Q16852	Gene names	ACACB, ACC2, ACCB
Domain Architecture
Description	Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) [Includes: Biotin carboxylase (EC 6.3.4.14)].

GUAA_HUMAN
θ value	0.0431538 (rank : 12)	NC score	0.158470 (rank : 12)
Query Neighborhood Hits	32	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	P49915	Gene names	GMPS
Domain Architecture
Description	GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (Glutamine amidotransferase) (GMP synthetase).

PUR2_MOUSE
θ value	0.0431538 (rank : 13)	NC score	0.102666 (rank : 16)
Query Neighborhood Hits	32	Target Neighborhood Hits	18	Shared Neighborhood Hits	7
SwissProt Accessions	Q64737, Q6NS48	Gene names	Gart
Domain Architecture
Description	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)].

EHD1_MOUSE
θ value	1.06291 (rank : 14)	NC score	0.027628 (rank : 21)
Query Neighborhood Hits	32	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WVK4	Gene names	Ehd1, Past1
Domain Architecture
Description	EH-domain-containing protein 1 (mPAST1).

PUR2_HUMAN
θ value	1.06291 (rank : 15)	NC score	0.108967 (rank : 15)
Query Neighborhood Hits	32	Target Neighborhood Hits	21	Shared Neighborhood Hits	10
SwissProt Accessions	P22102	Gene names	GART, PRGS
Domain Architecture
Description	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)].

EHD1_HUMAN
θ value	1.38821 (rank : 16)	NC score	0.029655 (rank : 18)
Query Neighborhood Hits	32	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H4M9, O14611, Q9UNR3	Gene names	EHD1, PAST, PAST1
Domain Architecture
Description	EH-domain-containing protein 1 (Testilin) (hPAST1).

BIR1A_MOUSE
θ value	1.81305 (rank : 17)	NC score	0.012070 (rank : 28)
Query Neighborhood Hits	32	Target Neighborhood Hits	94	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

SUCB2_MOUSE
θ value	1.81305 (rank : 18)	NC score	0.029473 (rank : 19)
Query Neighborhood Hits	32	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z2I8, Q3T9B8, Q3TJQ5, Q3TK63, Q66JT3, Q7TMY3, Q80VV1, Q8K2K9	Gene names	Suclg2
Domain Architecture	No domain graphic available
Description	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial precursor (EC 6.2.1.4) (Succinyl-CoA synthetase, betaG chain) (SCS-betaG) (GTP- specific succinyl-CoA synthetase subunit beta).

TM116_HUMAN
θ value	1.81305 (rank : 19)	NC score	0.068686 (rank : 17)
Query Neighborhood Hits	32	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NCL8, Q6NSH5, Q8IZ66	Gene names	TMEM116
Domain Architecture	No domain graphic available
Description	Transmembrane protein 116.

SUCB2_HUMAN
θ value	2.36792 (rank : 20)	NC score	0.028343 (rank : 20)
Query Neighborhood Hits	32	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q96I99, O95195, Q6NUH7, Q86VX8, Q8WUQ1	Gene names	SUCLG2
Domain Architecture	No domain graphic available
Description	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial precursor (EC 6.2.1.4) (Succinyl-CoA synthetase, betaG chain) (SCS-betaG) (GTP- specific succinyl-CoA synthetase subunit beta).

ILDR1_HUMAN
θ value	4.03905 (rank : 21)	NC score	0.018718 (rank : 24)
Query Neighborhood Hits	32	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q86SU0, Q6ZP61, Q7Z578	Gene names	ILDR1
Domain Architecture	No domain graphic available
Description	Immunoglobulin-like domain-containing receptor 1 precursor.

BRE1A_MOUSE
θ value	5.27518 (rank : 22)	NC score	0.006741 (rank : 31)
Query Neighborhood Hits	32	Target Neighborhood Hits	1025	Shared Neighborhood Hits	6
SwissProt Accessions	Q5DTM8, Q3UT10, Q3V350, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4	Gene names	Rnf20, Bre1a, Kiaa4116
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (RING finger protein 20).

BRE1A_HUMAN
θ value	6.88961 (rank : 23)	NC score	0.006155 (rank : 32)
Query Neighborhood Hits	32	Target Neighborhood Hits	1071	Shared Neighborhood Hits	7
SwissProt Accessions	Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83	Gene names	RNF20, BRE1A
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (hBRE1) (RING finger protein 20).

DAAM2_MOUSE
θ value	6.88961 (rank : 24)	NC score	0.009817 (rank : 29)
Query Neighborhood Hits	32	Target Neighborhood Hits	371	Shared Neighborhood Hits	6
SwissProt Accessions	Q80U19, Q810J5	Gene names	Daam2, Kiaa0381
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 2.

K0586_HUMAN
θ value	6.88961 (rank : 25)	NC score	0.027267 (rank : 22)
Query Neighborhood Hits	32	Target Neighborhood Hits	311	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BVV6, O60328	Gene names	KIAA0586
Domain Architecture	No domain graphic available
Description	Protein KIAA0586.

NELFA_MOUSE
θ value	6.88961 (rank : 26)	NC score	0.023188 (rank : 23)
Query Neighborhood Hits	32	Target Neighborhood Hits	195	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BG30, Q8BVE4, Q8VEI7, Q9CSJ9, Q9Z1V9	Gene names	Whsc2, Nelfa, Whsc2h
Domain Architecture	No domain graphic available
Description	Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 homolog) (mWHSC2).

ZNF38_HUMAN
θ value	6.88961 (rank : 27)	NC score	-0.001189 (rank : 34)
Query Neighborhood Hits	32	Target Neighborhood Hits	742	Shared Neighborhood Hits	2
SwissProt Accessions	P17036, P13683, Q9NNX8, Q9NXJ1, Q9UC15, Q9UC16	Gene names	ZNF38, KOX25, ZNF3
Domain Architecture
Description	Zinc finger protein 38 (Zinc finger protein KOX25) (Zinc finger protein HF.12) (Zinc finger protein 3) (HZF3.1).

ABTAP_HUMAN
θ value	8.99809 (rank : 28)	NC score	0.013841 (rank : 27)
Query Neighborhood Hits	32	Target Neighborhood Hits	290	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H501, Q86X92, Q9H9Q5, Q9HA35, Q9NX93, Q9P1S6	Gene names	ABTAP, C20orf6
Domain Architecture	No domain graphic available
Description	ABT1-associated protein.

CABL1_HUMAN
θ value	8.99809 (rank : 29)	NC score	0.016789 (rank : 25)
Query Neighborhood Hits	32	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TDN4, Q8N3Y8, Q8NA22, Q9BTG1	Gene names	CABLES1, CABLES
Domain Architecture	No domain graphic available
Description	CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1).

DAAM2_HUMAN
θ value	8.99809 (rank : 30)	NC score	0.008943 (rank : 30)
Query Neighborhood Hits	32	Target Neighborhood Hits	350	Shared Neighborhood Hits	6
SwissProt Accessions	Q86T65, Q5T4U0, Q9NQI5, Q9Y4G0	Gene names	DAAM2, KIAA0381
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 2.

NELFA_HUMAN
θ value	8.99809 (rank : 31)	NC score	0.015750 (rank : 26)
Query Neighborhood Hits	32	Target Neighborhood Hits	161	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H3P2, O95392	Gene names	WHSC2, NELFA
Domain Architecture	No domain graphic available
Description	Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein).

UACA_HUMAN
θ value	8.99809 (rank : 32)	NC score	0.000576 (rank : 33)
Query Neighborhood Hits	32	Target Neighborhood Hits	1622	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

OTC_HUMAN
θ value	θ > 10 (rank : 33)	NC score	0.128128 (rank : 14)
Query Neighborhood Hits	32	Target Neighborhood Hits	7	Shared Neighborhood Hits	1
SwissProt Accessions	P00480, Q6B0I1, Q9NYJ5	Gene names	OTC
Domain Architecture
Description	Ornithine carbamoyltransferase, mitochondrial precursor (EC 2.1.3.3) (OTCase) (Ornithine transcarbamylase).

OTC_MOUSE
θ value	θ > 10 (rank : 34)	NC score	0.131852 (rank : 13)
Query Neighborhood Hits	32	Target Neighborhood Hits	9	Shared Neighborhood Hits	1
SwissProt Accessions	P11725	Gene names	Otc
Domain Architecture
Description	Ornithine carbamoyltransferase, mitochondrial precursor (EC 2.1.3.3) (OTCase) (Ornithine transcarbamylase).

Hits sorted by NC score

CPSM_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	32	Target Neighborhood Hits	32	Shared Neighborhood Hits	32
SwissProt Accessions	Q8C196, Q6NX75	Gene names	Cps1
Domain Architecture	No domain graphic available
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

CPSM_HUMAN
NC score	0.998408 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	32	Target Neighborhood Hits	27	Shared Neighborhood Hits	21
SwissProt Accessions	P31327, O43774, Q7Z5I5	Gene names	CPS1
Domain Architecture
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

PYR1_HUMAN
NC score	0.917954 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	32	Target Neighborhood Hits	119	Shared Neighborhood Hits	13
SwissProt Accessions	P27708, Q6P0Q0	Gene names	CAD
Domain Architecture	No domain graphic available
Description	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)].

MCCA_HUMAN
NC score	0.414289 (rank : 4)	θ value	1.47974e-10 (rank : 5)
Query Neighborhood Hits	32	Target Neighborhood Hits	26	Shared Neighborhood Hits	13
SwissProt Accessions	Q96RQ3, Q59ES4, Q9H959, Q9NS97	Gene names	MCCC1, MCCA
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

PYC_MOUSE
NC score	0.410544 (rank : 5)	θ value	9.59137e-10 (rank : 6)
Query Neighborhood Hits	32	Target Neighborhood Hits	25	Shared Neighborhood Hits	11
SwissProt Accessions	Q05920	Gene names	Pc, Pcx
Domain Architecture
Description	Pyruvate carboxylase, mitochondrial precursor (EC 6.4.1.1) (Pyruvic carboxylase) (PCB).

PYC_HUMAN
NC score	0.404860 (rank : 6)	θ value	8.11959e-09 (rank : 8)
Query Neighborhood Hits	32	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	P11498, Q16705	Gene names	PC
Domain Architecture
Description	Pyruvate carboxylase, mitochondrial precursor (EC 6.4.1.1) (Pyruvic carboxylase) (PCB).

PCCA_MOUSE
NC score	0.400762 (rank : 7)	θ value	8.97725e-08 (rank : 9)
Query Neighborhood Hits	32	Target Neighborhood Hits	18	Shared Neighborhood Hits	12
SwissProt Accessions	Q91ZA3, Q80VU5, Q922N3	Gene names	Pcca
Domain Architecture	No domain graphic available
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

PCCA_HUMAN
NC score	0.399047 (rank : 8)	θ value	1.99992e-07 (rank : 10)
Query Neighborhood Hits	32	Target Neighborhood Hits	22	Shared Neighborhood Hits	13
SwissProt Accessions	P05165, Q15979	Gene names	PCCA
Domain Architecture
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

COA1_HUMAN
NC score	0.396681 (rank : 9)	θ value	6.64225e-11 (rank : 4)
Query Neighborhood Hits	32	Target Neighborhood Hits	49	Shared Neighborhood Hits	11
SwissProt Accessions	Q13085	Gene names	ACACA, ACAC, ACC1, ACCA
Domain Architecture
Description	Acetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)].

MCCA_MOUSE
NC score	0.391450 (rank : 10)	θ value	3.64472e-09 (rank : 7)
Query Neighborhood Hits	32	Target Neighborhood Hits	18	Shared Neighborhood Hits	13
SwissProt Accessions	Q99MR8, Q3TGU0, Q9D8R2	Gene names	Mccc1, Mcca
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

COA2_HUMAN
NC score	0.344981 (rank : 11)	θ value	1.43324e-05 (rank : 11)
Query Neighborhood Hits	32	Target Neighborhood Hits	184	Shared Neighborhood Hits	11
SwissProt Accessions	O00763, Q16852	Gene names	ACACB, ACC2, ACCB
Domain Architecture
Description	Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) [Includes: Biotin carboxylase (EC 6.3.4.14)].

GUAA_HUMAN
NC score	0.158470 (rank : 12)	θ value	0.0431538 (rank : 12)
Query Neighborhood Hits	32	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	P49915	Gene names	GMPS
Domain Architecture
Description	GMP synthase [glutamine-hydrolyzing] (EC 6.3.5.2) (Glutamine amidotransferase) (GMP synthetase).

OTC_MOUSE
NC score	0.131852 (rank : 13)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	32	Target Neighborhood Hits	9	Shared Neighborhood Hits	1
SwissProt Accessions	P11725	Gene names	Otc
Domain Architecture
Description	Ornithine carbamoyltransferase, mitochondrial precursor (EC 2.1.3.3) (OTCase) (Ornithine transcarbamylase).

OTC_HUMAN
NC score	0.128128 (rank : 14)	θ value	θ > 10 (rank : 33)
Query Neighborhood Hits	32	Target Neighborhood Hits	7	Shared Neighborhood Hits	1
SwissProt Accessions	P00480, Q6B0I1, Q9NYJ5	Gene names	OTC
Domain Architecture
Description	Ornithine carbamoyltransferase, mitochondrial precursor (EC 2.1.3.3) (OTCase) (Ornithine transcarbamylase).

PUR2_HUMAN
NC score	0.108967 (rank : 15)	θ value	1.06291 (rank : 15)
Query Neighborhood Hits	32	Target Neighborhood Hits	21	Shared Neighborhood Hits	10
SwissProt Accessions	P22102	Gene names	GART, PRGS
Domain Architecture
Description	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)].

PUR2_MOUSE
NC score	0.102666 (rank : 16)	θ value	0.0431538 (rank : 13)
Query Neighborhood Hits	32	Target Neighborhood Hits	18	Shared Neighborhood Hits	7
SwissProt Accessions	Q64737, Q6NS48	Gene names	Gart
Domain Architecture
Description	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)].

TM116_HUMAN
NC score	0.068686 (rank : 17)	θ value	1.81305 (rank : 19)
Query Neighborhood Hits	32	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NCL8, Q6NSH5, Q8IZ66	Gene names	TMEM116
Domain Architecture	No domain graphic available
Description	Transmembrane protein 116.

EHD1_HUMAN
NC score	0.029655 (rank : 18)	θ value	1.38821 (rank : 16)
Query Neighborhood Hits	32	Target Neighborhood Hits	36	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H4M9, O14611, Q9UNR3	Gene names	EHD1, PAST, PAST1
Domain Architecture
Description	EH-domain-containing protein 1 (Testilin) (hPAST1).

SUCB2_MOUSE
NC score	0.029473 (rank : 19)	θ value	1.81305 (rank : 18)
Query Neighborhood Hits	32	Target Neighborhood Hits	7	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Z2I8, Q3T9B8, Q3TJQ5, Q3TK63, Q66JT3, Q7TMY3, Q80VV1, Q8K2K9	Gene names	Suclg2
Domain Architecture	No domain graphic available
Description	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial precursor (EC 6.2.1.4) (Succinyl-CoA synthetase, betaG chain) (SCS-betaG) (GTP- specific succinyl-CoA synthetase subunit beta).

SUCB2_HUMAN
NC score	0.028343 (rank : 20)	θ value	2.36792 (rank : 20)
Query Neighborhood Hits	32	Target Neighborhood Hits	8	Shared Neighborhood Hits	3
SwissProt Accessions	Q96I99, O95195, Q6NUH7, Q86VX8, Q8WUQ1	Gene names	SUCLG2
Domain Architecture	No domain graphic available
Description	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial precursor (EC 6.2.1.4) (Succinyl-CoA synthetase, betaG chain) (SCS-betaG) (GTP- specific succinyl-CoA synthetase subunit beta).

EHD1_MOUSE
NC score	0.027628 (rank : 21)	θ value	1.06291 (rank : 14)
Query Neighborhood Hits	32	Target Neighborhood Hits	37	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WVK4	Gene names	Ehd1, Past1
Domain Architecture
Description	EH-domain-containing protein 1 (mPAST1).

K0586_HUMAN
NC score	0.027267 (rank : 22)	θ value	6.88961 (rank : 25)
Query Neighborhood Hits	32	Target Neighborhood Hits	311	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BVV6, O60328	Gene names	KIAA0586
Domain Architecture	No domain graphic available
Description	Protein KIAA0586.

NELFA_MOUSE
NC score	0.023188 (rank : 23)	θ value	6.88961 (rank : 26)
Query Neighborhood Hits	32	Target Neighborhood Hits	195	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BG30, Q8BVE4, Q8VEI7, Q9CSJ9, Q9Z1V9	Gene names	Whsc2, Nelfa, Whsc2h
Domain Architecture	No domain graphic available
Description	Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 homolog) (mWHSC2).

ILDR1_HUMAN
NC score	0.018718 (rank : 24)	θ value	4.03905 (rank : 21)
Query Neighborhood Hits	32	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q86SU0, Q6ZP61, Q7Z578	Gene names	ILDR1
Domain Architecture	No domain graphic available
Description	Immunoglobulin-like domain-containing receptor 1 precursor.

CABL1_HUMAN
NC score	0.016789 (rank : 25)	θ value	8.99809 (rank : 29)
Query Neighborhood Hits	32	Target Neighborhood Hits	37	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TDN4, Q8N3Y8, Q8NA22, Q9BTG1	Gene names	CABLES1, CABLES
Domain Architecture	No domain graphic available
Description	CDK5 and ABL1 enzyme substrate 1 (Interactor with CDK3 1) (Ik3-1).

NELFA_HUMAN
NC score	0.015750 (rank : 26)	θ value	8.99809 (rank : 31)
Query Neighborhood Hits	32	Target Neighborhood Hits	161	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H3P2, O95392	Gene names	WHSC2, NELFA
Domain Architecture	No domain graphic available
Description	Negative elongation factor A (NELF-A) (Wolf-Hirschhorn syndrome candidate 2 protein).

ABTAP_HUMAN
NC score	0.013841 (rank : 27)	θ value	8.99809 (rank : 28)
Query Neighborhood Hits	32	Target Neighborhood Hits	290	Shared Neighborhood Hits	5
SwissProt Accessions	Q9H501, Q86X92, Q9H9Q5, Q9HA35, Q9NX93, Q9P1S6	Gene names	ABTAP, C20orf6
Domain Architecture	No domain graphic available
Description	ABT1-associated protein.

BIR1A_MOUSE
NC score	0.012070 (rank : 28)	θ value	1.81305 (rank : 17)
Query Neighborhood Hits	32	Target Neighborhood Hits	94	Shared Neighborhood Hits	2
SwissProt Accessions	Q9QWK5, Q9JIB5, Q9R017	Gene names	Birc1a, Naip, Naip1
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1a (Neuronal apoptosis inhibitory protein 1).

DAAM2_MOUSE
NC score	0.009817 (rank : 29)	θ value	6.88961 (rank : 24)
Query Neighborhood Hits	32	Target Neighborhood Hits	371	Shared Neighborhood Hits	6
SwissProt Accessions	Q80U19, Q810J5	Gene names	Daam2, Kiaa0381
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 2.

DAAM2_HUMAN
NC score	0.008943 (rank : 30)	θ value	8.99809 (rank : 30)
Query Neighborhood Hits	32	Target Neighborhood Hits	350	Shared Neighborhood Hits	6
SwissProt Accessions	Q86T65, Q5T4U0, Q9NQI5, Q9Y4G0	Gene names	DAAM2, KIAA0381
Domain Architecture
Description	Disheveled-associated activator of morphogenesis 2.

BRE1A_MOUSE
NC score	0.006741 (rank : 31)	θ value	5.27518 (rank : 22)
Query Neighborhood Hits	32	Target Neighborhood Hits	1025	Shared Neighborhood Hits	6
SwissProt Accessions	Q5DTM8, Q3UT10, Q3V350, Q7TT11, Q8BKA8, Q8BKN8, Q8BUF7, Q8BVU4	Gene names	Rnf20, Bre1a, Kiaa4116
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (RING finger protein 20).

BRE1A_HUMAN
NC score	0.006155 (rank : 32)	θ value	6.88961 (rank : 23)
Query Neighborhood Hits	32	Target Neighborhood Hits	1071	Shared Neighborhood Hits	7
SwissProt Accessions	Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83	Gene names	RNF20, BRE1A
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (hBRE1) (RING finger protein 20).

UACA_HUMAN
NC score	0.000576 (rank : 33)	θ value	8.99809 (rank : 32)
Query Neighborhood Hits	32	Target Neighborhood Hits	1622	Shared Neighborhood Hits	8
SwissProt Accessions	Q9BZF9, Q8N3B8, Q9HCL1, Q9NWC6	Gene names	UACA, KIAA1561
Domain Architecture	No domain graphic available
Description	Uveal autoantigen with coiled-coil domains and ankyrin repeats protein.

ZNF38_HUMAN
NC score	-0.001189 (rank : 34)	θ value	6.88961 (rank : 27)
Query Neighborhood Hits	32	Target Neighborhood Hits	742	Shared Neighborhood Hits	2
SwissProt Accessions	P17036, P13683, Q9NNX8, Q9NXJ1, Q9UC15, Q9UC16	Gene names	ZNF38, KOX25, ZNF3
Domain Architecture
Description	Zinc finger protein 38 (Zinc finger protein KOX25) (Zinc finger protein HF.12) (Zinc finger protein 3) (HZF3.1).