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Network neighborhood for query Sequence : PCCA_MOUSE

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PCCA_MOUSE
SwissProt Accessions	Q91ZA3, Q80VU5, Q922N3	Gene names	Pcca
Domain Architecture	No domain graphic available
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PCCA_HUMAN
θ value	0 (rank : 1)	NC score	0.999289 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	22	Shared Neighborhood Hits	16
SwissProt Accessions	P05165, Q15979	Gene names	PCCA
Domain Architecture
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

PCCA_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q91ZA3, Q80VU5, Q922N3	Gene names	Pcca
Domain Architecture	No domain graphic available
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

MCCA_MOUSE
θ value	3.07662e-133 (rank : 3)	NC score	0.966377 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	Q99MR8, Q3TGU0, Q9D8R2	Gene names	Mccc1, Mcca
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

MCCA_HUMAN
θ value	1.33764e-128 (rank : 4)	NC score	0.965229 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	26	Shared Neighborhood Hits	14
SwissProt Accessions	Q96RQ3, Q59ES4, Q9H959, Q9NS97	Gene names	MCCC1, MCCA
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

PYC_MOUSE
θ value	4.6295e-105 (rank : 5)	NC score	0.930869 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	25	Shared Neighborhood Hits	11
SwissProt Accessions	Q05920	Gene names	Pc, Pcx
Domain Architecture
Description	Pyruvate carboxylase, mitochondrial precursor (EC 6.4.1.1) (Pyruvic carboxylase) (PCB).

PYC_HUMAN
θ value	6.68496e-104 (rank : 6)	NC score	0.931006 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	P11498, Q16705	Gene names	PC
Domain Architecture
Description	Pyruvate carboxylase, mitochondrial precursor (EC 6.4.1.1) (Pyruvic carboxylase) (PCB).

COA1_HUMAN
θ value	1.66577e-62 (rank : 7)	NC score	0.824099 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	49	Shared Neighborhood Hits	11
SwissProt Accessions	Q13085	Gene names	ACACA, ACAC, ACC1, ACCA
Domain Architecture
Description	Acetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)].

COA2_HUMAN
θ value	2.32979e-56 (rank : 8)	NC score	0.790193 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	184	Shared Neighborhood Hits	11
SwissProt Accessions	O00763, Q16852	Gene names	ACACB, ACC2, ACCB
Domain Architecture
Description	Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) [Includes: Biotin carboxylase (EC 6.3.4.14)].

PYR1_HUMAN
θ value	1.63604e-09 (rank : 9)	NC score	0.393927 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	119	Shared Neighborhood Hits	12
SwissProt Accessions	P27708, Q6P0Q0	Gene names	CAD
Domain Architecture	No domain graphic available
Description	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)].

CPSM_HUMAN
θ value	4.0297e-08 (rank : 10)	NC score	0.396408 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	27	Shared Neighborhood Hits	12
SwissProt Accessions	P31327, O43774, Q7Z5I5	Gene names	CPS1
Domain Architecture
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

CPSM_MOUSE
θ value	8.97725e-08 (rank : 11)	NC score	0.400762 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	32	Shared Neighborhood Hits	12
SwissProt Accessions	Q8C196, Q6NX75	Gene names	Cps1
Domain Architecture	No domain graphic available
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

APC7_MOUSE
θ value	0.0736092 (rank : 12)	NC score	0.077834 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	56	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WVM3, Q3UBM7, Q8BSR2, Q91W13	Gene names	Anapc7, Apc7
Domain Architecture
Description	Anaphase-promoting complex subunit 7 (APC7) (Cyclosome subunit 7) (Prediabetic NOD sera-reactive autoantigen).

APC7_HUMAN
θ value	1.81305 (rank : 13)	NC score	0.054740 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	57	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UJX3, Q96AC4, Q96GF4, Q9BU24, Q9NT16	Gene names	ANAPC7, APC7
Domain Architecture
Description	Anaphase-promoting complex subunit 7 (APC7) (Cyclosome subunit 7).

CDYL_MOUSE
θ value	3.0926 (rank : 14)	NC score	0.010456 (rank : 21)
Query Neighborhood Hits	18	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WTK2	Gene names	Cdyl
Domain Architecture
Description	Chromodomain Y-like protein (CDY-like).

PUR2_HUMAN
θ value	4.03905 (rank : 15)	NC score	0.048117 (rank : 20)
Query Neighborhood Hits	18	Target Neighborhood Hits	21	Shared Neighborhood Hits	9
SwissProt Accessions	P22102	Gene names	GART, PRGS
Domain Architecture
Description	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)].

ODB2_HUMAN
θ value	5.27518 (rank : 16)	NC score	0.065231 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	P11182	Gene names	DBT, BCATE2
Domain Architecture
Description	Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor (EC 2.3.1.168) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) (E2) (Dihydrolipoamide branched chain transacylase) (BCKAD E2 subunit).

MICA1_MOUSE
θ value	6.88961 (rank : 17)	NC score	0.004958 (rank : 22)
Query Neighborhood Hits	18	Target Neighborhood Hits	400	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VDP3	Gene names	Mical1, Mical, Nical
Domain Architecture
Description	NEDD9-interacting protein with calponin homology and LIM domains (Molecule interacting with CasL protein 1).

ODB2_MOUSE
θ value	6.88961 (rank : 18)	NC score	0.059910 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	6
SwissProt Accessions	P53395	Gene names	Dbt
Domain Architecture
Description	Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor (EC 2.3.1.168) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) (E2) (Dihydrolipoamide branched chain transacylase) (BCKAD E2 subunit).

HMGCL_HUMAN
θ value	θ > 10 (rank : 19)	NC score	0.054388 (rank : 19)
Query Neighborhood Hits	18	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	P35914, Q96FP8	Gene names	HMGCL
Domain Architecture
Description	Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (EC 4.1.3.4) (HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase).

HMGCL_MOUSE
θ value	θ > 10 (rank : 20)	NC score	0.062226 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	P38060	Gene names	Hmgcl
Domain Architecture
Description	Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (EC 4.1.3.4) (HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase).

PCCB_HUMAN
θ value	θ > 10 (rank : 21)	NC score	0.087818 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	P05166, Q16813	Gene names	PCCB
Domain Architecture
Description	Propionyl-CoA carboxylase beta chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit beta) (Propanoyl-CoA:carbon dioxide ligase subunit beta).

PCCB_MOUSE
θ value	θ > 10 (rank : 22)	NC score	0.090431 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q99MN9	Gene names	Pccb
Domain Architecture	No domain graphic available
Description	Propionyl-CoA carboxylase beta chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit beta) (Propanoyl-CoA:carbon dioxide ligase subunit beta).

Hits sorted by NC score

PCCA_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	18
SwissProt Accessions	Q91ZA3, Q80VU5, Q922N3	Gene names	Pcca
Domain Architecture	No domain graphic available
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

PCCA_HUMAN
NC score	0.999289 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	18	Target Neighborhood Hits	22	Shared Neighborhood Hits	16
SwissProt Accessions	P05165, Q15979	Gene names	PCCA
Domain Architecture
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

MCCA_MOUSE
NC score	0.966377 (rank : 3)	θ value	3.07662e-133 (rank : 3)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	Q99MR8, Q3TGU0, Q9D8R2	Gene names	Mccc1, Mcca
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

MCCA_HUMAN
NC score	0.965229 (rank : 4)	θ value	1.33764e-128 (rank : 4)
Query Neighborhood Hits	18	Target Neighborhood Hits	26	Shared Neighborhood Hits	14
SwissProt Accessions	Q96RQ3, Q59ES4, Q9H959, Q9NS97	Gene names	MCCC1, MCCA
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

PYC_HUMAN
NC score	0.931006 (rank : 5)	θ value	6.68496e-104 (rank : 6)
Query Neighborhood Hits	18	Target Neighborhood Hits	25	Shared Neighborhood Hits	12
SwissProt Accessions	P11498, Q16705	Gene names	PC
Domain Architecture
Description	Pyruvate carboxylase, mitochondrial precursor (EC 6.4.1.1) (Pyruvic carboxylase) (PCB).

PYC_MOUSE
NC score	0.930869 (rank : 6)	θ value	4.6295e-105 (rank : 5)
Query Neighborhood Hits	18	Target Neighborhood Hits	25	Shared Neighborhood Hits	11
SwissProt Accessions	Q05920	Gene names	Pc, Pcx
Domain Architecture
Description	Pyruvate carboxylase, mitochondrial precursor (EC 6.4.1.1) (Pyruvic carboxylase) (PCB).

COA1_HUMAN
NC score	0.824099 (rank : 7)	θ value	1.66577e-62 (rank : 7)
Query Neighborhood Hits	18	Target Neighborhood Hits	49	Shared Neighborhood Hits	11
SwissProt Accessions	Q13085	Gene names	ACACA, ACAC, ACC1, ACCA
Domain Architecture
Description	Acetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)].

COA2_HUMAN
NC score	0.790193 (rank : 8)	θ value	2.32979e-56 (rank : 8)
Query Neighborhood Hits	18	Target Neighborhood Hits	184	Shared Neighborhood Hits	11
SwissProt Accessions	O00763, Q16852	Gene names	ACACB, ACC2, ACCB
Domain Architecture
Description	Acetyl-CoA carboxylase 2 (EC 6.4.1.2) (ACC-beta) [Includes: Biotin carboxylase (EC 6.3.4.14)].

CPSM_MOUSE
NC score	0.400762 (rank : 9)	θ value	8.97725e-08 (rank : 11)
Query Neighborhood Hits	18	Target Neighborhood Hits	32	Shared Neighborhood Hits	12
SwissProt Accessions	Q8C196, Q6NX75	Gene names	Cps1
Domain Architecture	No domain graphic available
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

CPSM_HUMAN
NC score	0.396408 (rank : 10)	θ value	4.0297e-08 (rank : 10)
Query Neighborhood Hits	18	Target Neighborhood Hits	27	Shared Neighborhood Hits	12
SwissProt Accessions	P31327, O43774, Q7Z5I5	Gene names	CPS1
Domain Architecture
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

PYR1_HUMAN
NC score	0.393927 (rank : 11)	θ value	1.63604e-09 (rank : 9)
Query Neighborhood Hits	18	Target Neighborhood Hits	119	Shared Neighborhood Hits	12
SwissProt Accessions	P27708, Q6P0Q0	Gene names	CAD
Domain Architecture	No domain graphic available
Description	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)].

PCCB_MOUSE
NC score	0.090431 (rank : 12)	θ value	θ > 10 (rank : 22)
Query Neighborhood Hits	18	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	Q99MN9	Gene names	Pccb
Domain Architecture	No domain graphic available
Description	Propionyl-CoA carboxylase beta chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit beta) (Propanoyl-CoA:carbon dioxide ligase subunit beta).

PCCB_HUMAN
NC score	0.087818 (rank : 13)	θ value	θ > 10 (rank : 21)
Query Neighborhood Hits	18	Target Neighborhood Hits	8	Shared Neighborhood Hits	2
SwissProt Accessions	P05166, Q16813	Gene names	PCCB
Domain Architecture
Description	Propionyl-CoA carboxylase beta chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit beta) (Propanoyl-CoA:carbon dioxide ligase subunit beta).

APC7_MOUSE
NC score	0.077834 (rank : 14)	θ value	0.0736092 (rank : 12)
Query Neighborhood Hits	18	Target Neighborhood Hits	56	Shared Neighborhood Hits	4
SwissProt Accessions	Q9WVM3, Q3UBM7, Q8BSR2, Q91W13	Gene names	Anapc7, Apc7
Domain Architecture
Description	Anaphase-promoting complex subunit 7 (APC7) (Cyclosome subunit 7) (Prediabetic NOD sera-reactive autoantigen).

ODB2_HUMAN
NC score	0.065231 (rank : 15)	θ value	5.27518 (rank : 16)
Query Neighborhood Hits	18	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	P11182	Gene names	DBT, BCATE2
Domain Architecture
Description	Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor (EC 2.3.1.168) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) (E2) (Dihydrolipoamide branched chain transacylase) (BCKAD E2 subunit).

HMGCL_MOUSE
NC score	0.062226 (rank : 16)	θ value	θ > 10 (rank : 20)
Query Neighborhood Hits	18	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	P38060	Gene names	Hmgcl
Domain Architecture
Description	Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (EC 4.1.3.4) (HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase).

ODB2_MOUSE
NC score	0.059910 (rank : 17)	θ value	6.88961 (rank : 18)
Query Neighborhood Hits	18	Target Neighborhood Hits	18	Shared Neighborhood Hits	6
SwissProt Accessions	P53395	Gene names	Dbt
Domain Architecture
Description	Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor (EC 2.3.1.168) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) (E2) (Dihydrolipoamide branched chain transacylase) (BCKAD E2 subunit).

APC7_HUMAN
NC score	0.054740 (rank : 18)	θ value	1.81305 (rank : 13)
Query Neighborhood Hits	18	Target Neighborhood Hits	57	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UJX3, Q96AC4, Q96GF4, Q9BU24, Q9NT16	Gene names	ANAPC7, APC7
Domain Architecture
Description	Anaphase-promoting complex subunit 7 (APC7) (Cyclosome subunit 7).

HMGCL_HUMAN
NC score	0.054388 (rank : 19)	θ value	θ > 10 (rank : 19)
Query Neighborhood Hits	18	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	P35914, Q96FP8	Gene names	HMGCL
Domain Architecture
Description	Hydroxymethylglutaryl-CoA lyase, mitochondrial precursor (EC 4.1.3.4) (HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase).

PUR2_HUMAN
NC score	0.048117 (rank : 20)	θ value	4.03905 (rank : 15)
Query Neighborhood Hits	18	Target Neighborhood Hits	21	Shared Neighborhood Hits	9
SwissProt Accessions	P22102	Gene names	GART, PRGS
Domain Architecture
Description	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)].

CDYL_MOUSE
NC score	0.010456 (rank : 21)	θ value	3.0926 (rank : 14)
Query Neighborhood Hits	18	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WTK2	Gene names	Cdyl
Domain Architecture
Description	Chromodomain Y-like protein (CDY-like).

MICA1_MOUSE
NC score	0.004958 (rank : 22)	θ value	6.88961 (rank : 17)
Query Neighborhood Hits	18	Target Neighborhood Hits	400	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VDP3	Gene names	Mical1, Mical, Nical
Domain Architecture
Description	NEDD9-interacting protein with calponin homology and LIM domains (Molecule interacting with CasL protein 1).