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Network neighborhood for query Sequence : ODB2_HUMAN

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ODB2_HUMAN
SwissProt Accessions	P11182	Gene names	DBT, BCATE2
Domain Architecture
Description	Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor (EC 2.3.1.168) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) (E2) (Dihydrolipoamide branched chain transacylase) (BCKAD E2 subunit).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ODB2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	19
SwissProt Accessions	P11182	Gene names	DBT, BCATE2
Domain Architecture
Description	Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor (EC 2.3.1.168) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) (E2) (Dihydrolipoamide branched chain transacylase) (BCKAD E2 subunit).

ODB2_MOUSE
θ value	0 (rank : 2)	NC score	0.999147 (rank : 2)
Query Neighborhood Hits	19	Target Neighborhood Hits	18	Shared Neighborhood Hits	17
SwissProt Accessions	P53395	Gene names	Dbt
Domain Architecture
Description	Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor (EC 2.3.1.168) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) (E2) (Dihydrolipoamide branched chain transacylase) (BCKAD E2 subunit).

ODP2_HUMAN
θ value	2.26708e-35 (rank : 3)	NC score	0.819059 (rank : 3)
Query Neighborhood Hits	19	Target Neighborhood Hits	59	Shared Neighborhood Hits	7
SwissProt Accessions	P10515, Q16783	Gene names	DLAT, DLTA
Domain Architecture
Description	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial precursor (EC 2.3.1.12) (Pyruvate dehydrogenase complex E2 subunit) (PDCE2) (E2) (Dihydrolipoamide S- acetyltransferase component of pyruvate dehydrogenase complex) (PDC- E2) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (M2 antigen complex 70 kDa subunit).

ODPX_HUMAN
θ value	4.72714e-33 (rank : 4)	NC score	0.807893 (rank : 5)
Query Neighborhood Hits	19	Target Neighborhood Hits	24	Shared Neighborhood Hits	9
SwissProt Accessions	O00330, O60221, Q96FV8, Q99783	Gene names	PDHX, PDX1
Domain Architecture
Description	Pyruvate dehydrogenase protein X component, mitochondrial precursor (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (Lipoyl-containing pyruvate dehydrogenase complex component X) (E3-binding protein) (E3BP) (proX).

ODPX_MOUSE
θ value	8.06329e-33 (rank : 5)	NC score	0.808743 (rank : 4)
Query Neighborhood Hits	19	Target Neighborhood Hits	32	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BKZ9	Gene names	Pdhx
Domain Architecture	No domain graphic available
Description	Pyruvate dehydrogenase protein X component, mitochondrial precursor (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (Lipoyl-containing pyruvate dehydrogenase complex component X).

ODO2_MOUSE
θ value	6.61148e-27 (rank : 6)	NC score	0.758854 (rank : 7)
Query Neighborhood Hits	19	Target Neighborhood Hits	85	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D2G2	Gene names	Dlst
Domain Architecture	No domain graphic available
Description	Dihydrolipoyllysine-residue succinyltransferase component of 2- oxoglutarate dehydrogenase complex, mitochondrial precursor (EC 2.3.1.61) (Dihydrolipoamide succinyltransferase component of 2- oxoglutarate dehydrogenase complex) (E2) (E2K).

ODO2_HUMAN
θ value	1.92365e-26 (rank : 7)	NC score	0.764564 (rank : 6)
Query Neighborhood Hits	19	Target Neighborhood Hits	58	Shared Neighborhood Hits	7
SwissProt Accessions	P36957, Q9BQ32	Gene names	DLST, DLTS
Domain Architecture
Description	Dihydrolipoyllysine-residue succinyltransferase component of 2- oxoglutarate dehydrogenase complex, mitochondrial precursor (EC 2.3.1.61) (Dihydrolipoamide succinyltransferase component of 2- oxoglutarate dehydrogenase complex) (E2) (E2K).

MCCA_HUMAN
θ value	0.00509761 (rank : 8)	NC score	0.124514 (rank : 8)
Query Neighborhood Hits	19	Target Neighborhood Hits	26	Shared Neighborhood Hits	8
SwissProt Accessions	Q96RQ3, Q59ES4, Q9H959, Q9NS97	Gene names	MCCC1, MCCA
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

MCCA_MOUSE
θ value	0.0563607 (rank : 9)	NC score	0.115456 (rank : 9)
Query Neighborhood Hits	19	Target Neighborhood Hits	18	Shared Neighborhood Hits	8
SwissProt Accessions	Q99MR8, Q3TGU0, Q9D8R2	Gene names	Mccc1, Mcca
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

PCCA_HUMAN
θ value	0.813845 (rank : 10)	NC score	0.076487 (rank : 10)
Query Neighborhood Hits	19	Target Neighborhood Hits	22	Shared Neighborhood Hits	6
SwissProt Accessions	P05165, Q15979	Gene names	PCCA
Domain Architecture
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

CAD10_HUMAN
θ value	1.38821 (rank : 11)	NC score	0.010018 (rank : 17)
Query Neighborhood Hits	19	Target Neighborhood Hits	162	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6N8, Q9ULB3	Gene names	CDH10
Domain Architecture
Description	Cadherin-10 precursor (T2-cadherin).

ITA3_MOUSE
θ value	2.36792 (rank : 12)	NC score	0.019387 (rank : 13)
Query Neighborhood Hits	19	Target Neighborhood Hits	54	Shared Neighborhood Hits	3
SwissProt Accessions	Q62470, Q08441, Q08442	Gene names	Itga3
Domain Architecture
Description	Integrin alpha-3 precursor (Galactoprotein B3) (GAPB3) (VLA-3 alpha chain) (CD49c antigen) [Contains: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain].

AOF1_MOUSE
θ value	4.03905 (rank : 13)	NC score	0.025891 (rank : 12)
Query Neighborhood Hits	19	Target Neighborhood Hits	51	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CIG3, Q8C5C4, Q8CEC1	Gene names	Aof1
Domain Architecture	No domain graphic available
Description	Flavin-containing amine oxidase domain-containing protein 1 (EC 1.-.-.-).

GRHL1_HUMAN
θ value	5.27518 (rank : 14)	NC score	0.017115 (rank : 15)
Query Neighborhood Hits	19	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZI5, Q53T93, Q6NWN7, Q6NWN8, Q6NWN9, Q8NI33	Gene names	GRHL1, LBP32, MGR, TFCP2L2
Domain Architecture	No domain graphic available
Description	Grainyhead-like protein 1 homolog (Transcription factor CP2-like 2) (Transcription factor LBP-32) (NH32) (Mammalian grainyhead).

GRHL1_MOUSE
θ value	5.27518 (rank : 15)	NC score	0.017011 (rank : 16)
Query Neighborhood Hits	19	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q921D9, Q8K5C1	Gene names	Grhl1, Mgr, Tcfcp2l2
Domain Architecture	No domain graphic available
Description	Grainyhead-like protein 1 homolog (Transcription factor CP2-like 2) (Transcription factor LBP-32).

MCM5_MOUSE
θ value	5.27518 (rank : 16)	NC score	0.018706 (rank : 14)
Query Neighborhood Hits	19	Target Neighborhood Hits	36	Shared Neighborhood Hits	3
SwissProt Accessions	P49718	Gene names	Mcm5, Cdc46, Mcmd5
Domain Architecture
Description	DNA replication licensing factor MCM5 (CDC46 homolog) (P1-CDC46).

PCCA_MOUSE
θ value	5.27518 (rank : 17)	NC score	0.065231 (rank : 11)
Query Neighborhood Hits	19	Target Neighborhood Hits	18	Shared Neighborhood Hits	6
SwissProt Accessions	Q91ZA3, Q80VU5, Q922N3	Gene names	Pcca
Domain Architecture	No domain graphic available
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

TIE2_HUMAN
θ value	5.27518 (rank : 18)	NC score	0.003027 (rank : 18)
Query Neighborhood Hits	19	Target Neighborhood Hits	1192	Shared Neighborhood Hits	4
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TIE2_MOUSE
θ value	8.99809 (rank : 19)	NC score	0.001917 (rank : 19)
Query Neighborhood Hits	19	Target Neighborhood Hits	1204	Shared Neighborhood Hits	4
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).

Hits sorted by NC score

ODB2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	19	Target Neighborhood Hits	19	Shared Neighborhood Hits	19
SwissProt Accessions	P11182	Gene names	DBT, BCATE2
Domain Architecture
Description	Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor (EC 2.3.1.168) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) (E2) (Dihydrolipoamide branched chain transacylase) (BCKAD E2 subunit).

ODB2_MOUSE
NC score	0.999147 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	19	Target Neighborhood Hits	18	Shared Neighborhood Hits	17
SwissProt Accessions	P53395	Gene names	Dbt
Domain Architecture
Description	Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor (EC 2.3.1.168) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) (E2) (Dihydrolipoamide branched chain transacylase) (BCKAD E2 subunit).

ODP2_HUMAN
NC score	0.819059 (rank : 3)	θ value	2.26708e-35 (rank : 3)
Query Neighborhood Hits	19	Target Neighborhood Hits	59	Shared Neighborhood Hits	7
SwissProt Accessions	P10515, Q16783	Gene names	DLAT, DLTA
Domain Architecture
Description	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial precursor (EC 2.3.1.12) (Pyruvate dehydrogenase complex E2 subunit) (PDCE2) (E2) (Dihydrolipoamide S- acetyltransferase component of pyruvate dehydrogenase complex) (PDC- E2) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (M2 antigen complex 70 kDa subunit).

ODPX_MOUSE
NC score	0.808743 (rank : 4)	θ value	8.06329e-33 (rank : 5)
Query Neighborhood Hits	19	Target Neighborhood Hits	32	Shared Neighborhood Hits	9
SwissProt Accessions	Q8BKZ9	Gene names	Pdhx
Domain Architecture	No domain graphic available
Description	Pyruvate dehydrogenase protein X component, mitochondrial precursor (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (Lipoyl-containing pyruvate dehydrogenase complex component X).

ODPX_HUMAN
NC score	0.807893 (rank : 5)	θ value	4.72714e-33 (rank : 4)
Query Neighborhood Hits	19	Target Neighborhood Hits	24	Shared Neighborhood Hits	9
SwissProt Accessions	O00330, O60221, Q96FV8, Q99783	Gene names	PDHX, PDX1
Domain Architecture
Description	Pyruvate dehydrogenase protein X component, mitochondrial precursor (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (Lipoyl-containing pyruvate dehydrogenase complex component X) (E3-binding protein) (E3BP) (proX).

ODO2_HUMAN
NC score	0.764564 (rank : 6)	θ value	1.92365e-26 (rank : 7)
Query Neighborhood Hits	19	Target Neighborhood Hits	58	Shared Neighborhood Hits	7
SwissProt Accessions	P36957, Q9BQ32	Gene names	DLST, DLTS
Domain Architecture
Description	Dihydrolipoyllysine-residue succinyltransferase component of 2- oxoglutarate dehydrogenase complex, mitochondrial precursor (EC 2.3.1.61) (Dihydrolipoamide succinyltransferase component of 2- oxoglutarate dehydrogenase complex) (E2) (E2K).

ODO2_MOUSE
NC score	0.758854 (rank : 7)	θ value	6.61148e-27 (rank : 6)
Query Neighborhood Hits	19	Target Neighborhood Hits	85	Shared Neighborhood Hits	7
SwissProt Accessions	Q9D2G2	Gene names	Dlst
Domain Architecture	No domain graphic available
Description	Dihydrolipoyllysine-residue succinyltransferase component of 2- oxoglutarate dehydrogenase complex, mitochondrial precursor (EC 2.3.1.61) (Dihydrolipoamide succinyltransferase component of 2- oxoglutarate dehydrogenase complex) (E2) (E2K).

MCCA_HUMAN
NC score	0.124514 (rank : 8)	θ value	0.00509761 (rank : 8)
Query Neighborhood Hits	19	Target Neighborhood Hits	26	Shared Neighborhood Hits	8
SwissProt Accessions	Q96RQ3, Q59ES4, Q9H959, Q9NS97	Gene names	MCCC1, MCCA
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

MCCA_MOUSE
NC score	0.115456 (rank : 9)	θ value	0.0563607 (rank : 9)
Query Neighborhood Hits	19	Target Neighborhood Hits	18	Shared Neighborhood Hits	8
SwissProt Accessions	Q99MR8, Q3TGU0, Q9D8R2	Gene names	Mccc1, Mcca
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

PCCA_HUMAN
NC score	0.076487 (rank : 10)	θ value	0.813845 (rank : 10)
Query Neighborhood Hits	19	Target Neighborhood Hits	22	Shared Neighborhood Hits	6
SwissProt Accessions	P05165, Q15979	Gene names	PCCA
Domain Architecture
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

PCCA_MOUSE
NC score	0.065231 (rank : 11)	θ value	5.27518 (rank : 17)
Query Neighborhood Hits	19	Target Neighborhood Hits	18	Shared Neighborhood Hits	6
SwissProt Accessions	Q91ZA3, Q80VU5, Q922N3	Gene names	Pcca
Domain Architecture	No domain graphic available
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

AOF1_MOUSE
NC score	0.025891 (rank : 12)	θ value	4.03905 (rank : 13)
Query Neighborhood Hits	19	Target Neighborhood Hits	51	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CIG3, Q8C5C4, Q8CEC1	Gene names	Aof1
Domain Architecture	No domain graphic available
Description	Flavin-containing amine oxidase domain-containing protein 1 (EC 1.-.-.-).

ITA3_MOUSE
NC score	0.019387 (rank : 13)	θ value	2.36792 (rank : 12)
Query Neighborhood Hits	19	Target Neighborhood Hits	54	Shared Neighborhood Hits	3
SwissProt Accessions	Q62470, Q08441, Q08442	Gene names	Itga3
Domain Architecture
Description	Integrin alpha-3 precursor (Galactoprotein B3) (GAPB3) (VLA-3 alpha chain) (CD49c antigen) [Contains: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain].

MCM5_MOUSE
NC score	0.018706 (rank : 14)	θ value	5.27518 (rank : 16)
Query Neighborhood Hits	19	Target Neighborhood Hits	36	Shared Neighborhood Hits	3
SwissProt Accessions	P49718	Gene names	Mcm5, Cdc46, Mcmd5
Domain Architecture
Description	DNA replication licensing factor MCM5 (CDC46 homolog) (P1-CDC46).

GRHL1_HUMAN
NC score	0.017115 (rank : 15)	θ value	5.27518 (rank : 14)
Query Neighborhood Hits	19	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZI5, Q53T93, Q6NWN7, Q6NWN8, Q6NWN9, Q8NI33	Gene names	GRHL1, LBP32, MGR, TFCP2L2
Domain Architecture	No domain graphic available
Description	Grainyhead-like protein 1 homolog (Transcription factor CP2-like 2) (Transcription factor LBP-32) (NH32) (Mammalian grainyhead).

GRHL1_MOUSE
NC score	0.017011 (rank : 16)	θ value	5.27518 (rank : 15)
Query Neighborhood Hits	19	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q921D9, Q8K5C1	Gene names	Grhl1, Mgr, Tcfcp2l2
Domain Architecture	No domain graphic available
Description	Grainyhead-like protein 1 homolog (Transcription factor CP2-like 2) (Transcription factor LBP-32).

CAD10_HUMAN
NC score	0.010018 (rank : 17)	θ value	1.38821 (rank : 11)
Query Neighborhood Hits	19	Target Neighborhood Hits	162	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y6N8, Q9ULB3	Gene names	CDH10
Domain Architecture
Description	Cadherin-10 precursor (T2-cadherin).

TIE2_HUMAN
NC score	0.003027 (rank : 18)	θ value	5.27518 (rank : 18)
Query Neighborhood Hits	19	Target Neighborhood Hits	1192	Shared Neighborhood Hits	4
SwissProt Accessions	Q02763	Gene names	TEK, TIE2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (CD202b antigen).

TIE2_MOUSE
NC score	0.001917 (rank : 19)	θ value	8.99809 (rank : 19)
Query Neighborhood Hits	19	Target Neighborhood Hits	1204	Shared Neighborhood Hits	4
SwissProt Accessions	Q02858	Gene names	Tek, Hyk, Tie-2, Tie2
Domain Architecture
Description	Angiopoietin-1 receptor precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (Tyrosine-protein kinase receptor TEK) (p140 TEK) (Tunica interna endothelial cell kinase) (HYK) (STK1) (CD202b antigen).