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Network neighborhood for query Sequence : ODPX_MOUSE

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ODPX_MOUSE
SwissProt Accessions	Q8BKZ9	Gene names	Pdhx
Domain Architecture	No domain graphic available
Description	Pyruvate dehydrogenase protein X component, mitochondrial precursor (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (Lipoyl-containing pyruvate dehydrogenase complex component X).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

ODPX_HUMAN
θ value	0 (rank : 1)	NC score	0.992209 (rank : 2)
Query Neighborhood Hits	32	Target Neighborhood Hits	24	Shared Neighborhood Hits	11
SwissProt Accessions	O00330, O60221, Q96FV8, Q99783	Gene names	PDHX, PDX1
Domain Architecture
Description	Pyruvate dehydrogenase protein X component, mitochondrial precursor (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (Lipoyl-containing pyruvate dehydrogenase complex component X) (E3-binding protein) (E3BP) (proX).

ODPX_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	32	Target Neighborhood Hits	32	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BKZ9	Gene names	Pdhx
Domain Architecture	No domain graphic available
Description	Pyruvate dehydrogenase protein X component, mitochondrial precursor (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (Lipoyl-containing pyruvate dehydrogenase complex component X).

ODP2_HUMAN
θ value	1.31376e-75 (rank : 3)	NC score	0.925731 (rank : 3)
Query Neighborhood Hits	32	Target Neighborhood Hits	59	Shared Neighborhood Hits	9
SwissProt Accessions	P10515, Q16783	Gene names	DLAT, DLTA
Domain Architecture
Description	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial precursor (EC 2.3.1.12) (Pyruvate dehydrogenase complex E2 subunit) (PDCE2) (E2) (Dihydrolipoamide S- acetyltransferase component of pyruvate dehydrogenase complex) (PDC- E2) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (M2 antigen complex 70 kDa subunit).

ODB2_HUMAN
θ value	8.06329e-33 (rank : 4)	NC score	0.808743 (rank : 4)
Query Neighborhood Hits	32	Target Neighborhood Hits	19	Shared Neighborhood Hits	9
SwissProt Accessions	P11182	Gene names	DBT, BCATE2
Domain Architecture
Description	Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor (EC 2.3.1.168) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) (E2) (Dihydrolipoamide branched chain transacylase) (BCKAD E2 subunit).

ODB2_MOUSE
θ value	5.22648e-32 (rank : 5)	NC score	0.802154 (rank : 5)
Query Neighborhood Hits	32	Target Neighborhood Hits	18	Shared Neighborhood Hits	9
SwissProt Accessions	P53395	Gene names	Dbt
Domain Architecture
Description	Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor (EC 2.3.1.168) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) (E2) (Dihydrolipoamide branched chain transacylase) (BCKAD E2 subunit).

ODO2_MOUSE
θ value	1.99067e-23 (rank : 6)	NC score	0.739085 (rank : 7)
Query Neighborhood Hits	32	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D2G2	Gene names	Dlst
Domain Architecture	No domain graphic available
Description	Dihydrolipoyllysine-residue succinyltransferase component of 2- oxoglutarate dehydrogenase complex, mitochondrial precursor (EC 2.3.1.61) (Dihydrolipoamide succinyltransferase component of 2- oxoglutarate dehydrogenase complex) (E2) (E2K).

ODO2_HUMAN
θ value	1.6852e-22 (rank : 7)	NC score	0.745265 (rank : 6)
Query Neighborhood Hits	32	Target Neighborhood Hits	58	Shared Neighborhood Hits	8
SwissProt Accessions	P36957, Q9BQ32	Gene names	DLST, DLTS
Domain Architecture
Description	Dihydrolipoyllysine-residue succinyltransferase component of 2- oxoglutarate dehydrogenase complex, mitochondrial precursor (EC 2.3.1.61) (Dihydrolipoamide succinyltransferase component of 2- oxoglutarate dehydrogenase complex) (E2) (E2K).

RFIP1_MOUSE
θ value	0.00509761 (rank : 8)	NC score	0.099022 (rank : 8)
Query Neighborhood Hits	32	Target Neighborhood Hits	152	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

MCCA_MOUSE
θ value	0.0961366 (rank : 9)	NC score	0.091044 (rank : 9)
Query Neighborhood Hits	32	Target Neighborhood Hits	18	Shared Neighborhood Hits	7
SwissProt Accessions	Q99MR8, Q3TGU0, Q9D8R2	Gene names	Mccc1, Mcca
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

MAGE1_HUMAN
θ value	0.21417 (rank : 10)	NC score	0.019307 (rank : 18)
Query Neighborhood Hits	32	Target Neighborhood Hits	1389	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

SAPS1_HUMAN
θ value	0.21417 (rank : 11)	NC score	0.028239 (rank : 15)
Query Neighborhood Hits	32	Target Neighborhood Hits	704	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

MCCA_HUMAN
θ value	0.279714 (rank : 12)	NC score	0.090070 (rank : 10)
Query Neighborhood Hits	32	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	Q96RQ3, Q59ES4, Q9H959, Q9NS97	Gene names	MCCC1, MCCA
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

ARRB2_HUMAN
θ value	0.62314 (rank : 13)	NC score	0.023551 (rank : 17)
Query Neighborhood Hits	32	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	P32121, Q0Z8D3, Q2PP19, Q6ICT3, Q8N7Y2, Q9UEQ6	Gene names	ARRB2, ARB2, ARR2
Domain Architecture
Description	Beta-arrestin-2 (Arrestin beta 2).

DNMT1_HUMAN
θ value	0.62314 (rank : 14)	NC score	0.028882 (rank : 14)
Query Neighborhood Hits	32	Target Neighborhood Hits	401	Shared Neighborhood Hits	2
SwissProt Accessions	P26358, Q9UHG5, Q9ULA2, Q9UMZ6	Gene names	DNMT1, AIM, DNMT
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 1 (EC 2.1.1.37) (Dnmt1) (DNA methyltransferase HsaI) (DNA MTase HsaI) (MCMT) (M.HsaI).

RUNX2_MOUSE
θ value	0.813845 (rank : 15)	NC score	0.036490 (rank : 12)
Query Neighborhood Hits	32	Target Neighborhood Hits	119	Shared Neighborhood Hits	4
SwissProt Accessions	Q08775, O35183, Q08776, Q9JLN0, Q9QUQ6, Q9QY29, Q9R0U4, Q9Z2J7	Gene names	Runx2, Aml3, Cbfa1, Osf2, Pebp2a
Domain Architecture
Description	Runt-related transcription factor 2 (Core-binding factor, alpha 1 subunit) (CBF-alpha 1) (Acute myeloid leukemia 3 protein) (Oncogene AML-3) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEBP2-alpha A) (PEA2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) (Osteoblast- specific transcription factor 2) (OSF-2).

COA1_HUMAN
θ value	1.06291 (rank : 16)	NC score	0.053320 (rank : 11)
Query Neighborhood Hits	32	Target Neighborhood Hits	49	Shared Neighborhood Hits	5
SwissProt Accessions	Q13085	Gene names	ACACA, ACAC, ACC1, ACCA
Domain Architecture
Description	Acetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)].

RUNX2_HUMAN
θ value	1.06291 (rank : 17)	NC score	0.035371 (rank : 13)
Query Neighborhood Hits	32	Target Neighborhood Hits	103	Shared Neighborhood Hits	4
SwissProt Accessions	Q13950, O14614, O14615, O95181	Gene names	RUNX2, AML3, CBFA1, OSF2, PEBP2A
Domain Architecture
Description	Runt-related transcription factor 2 (Core-binding factor, alpha 1 subunit) (CBF-alpha 1) (Acute myeloid leukemia 3 protein) (Oncogene AML-3) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEBP2-alpha A) (PEA2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) (Osteoblast- specific transcription factor 2) (OSF-2).

OPT_HUMAN
θ value	1.38821 (rank : 18)	NC score	0.013698 (rank : 22)
Query Neighborhood Hits	32	Target Neighborhood Hits	255	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UBM4	Gene names	OPTC, OPT
Domain Architecture	No domain graphic available
Description	Opticin precursor (Oculoglycan).

EDN3_MOUSE
θ value	2.36792 (rank : 19)	NC score	0.027630 (rank : 16)
Query Neighborhood Hits	32	Target Neighborhood Hits	61	Shared Neighborhood Hits	2
SwissProt Accessions	P48299, Q543L0	Gene names	Edn3
Domain Architecture
Description	Endothelin-3 precursor (ET-3) (Preproendothelin-3) (PPET3).

EFS_MOUSE
θ value	2.36792 (rank : 20)	NC score	0.019218 (rank : 19)
Query Neighborhood Hits	32	Target Neighborhood Hits	389	Shared Neighborhood Hits	5
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

KIF2C_HUMAN
θ value	2.36792 (rank : 21)	NC score	0.008807 (rank : 27)
Query Neighborhood Hits	32	Target Neighborhood Hits	138	Shared Neighborhood Hits	2
SwissProt Accessions	Q99661, Q96C18, Q96HB8, Q9BWV8	Gene names	KIF2C, KNSL6
Domain Architecture
Description	Kinesin-like protein KIF2C (Mitotic centromere-associated kinesin) (MCAK) (Kinesin-like protein 6).

CAC1S_MOUSE
θ value	4.03905 (rank : 22)	NC score	0.006866 (rank : 28)
Query Neighborhood Hits	32	Target Neighborhood Hits	98	Shared Neighborhood Hits	2
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

FBLN2_MOUSE
θ value	4.03905 (rank : 23)	NC score	0.006286 (rank : 29)
Query Neighborhood Hits	32	Target Neighborhood Hits	505	Shared Neighborhood Hits	4
SwissProt Accessions	P37889, Q9WUI2	Gene names	Fbln2
Domain Architecture
Description	Fibulin-2 precursor.

NCOR2_HUMAN
θ value	4.03905 (rank : 24)	NC score	0.014139 (rank : 21)
Query Neighborhood Hits	32	Target Neighborhood Hits	870	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

UBP43_MOUSE
θ value	5.27518 (rank : 25)	NC score	0.008937 (rank : 26)
Query Neighborhood Hits	32	Target Neighborhood Hits	130	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BUM9, Q8VDP5	Gene names	Usp43
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.1.2.15) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) (Deubiquitinating enzyme 43).

UBP53_MOUSE
θ value	5.27518 (rank : 26)	NC score	0.013431 (rank : 23)
Query Neighborhood Hits	32	Target Neighborhood Hits	188	Shared Neighborhood Hits	3
SwissProt Accessions	P15975, Q8CB37, Q8R251	Gene names	Usp53, Phxr3
Domain Architecture	No domain graphic available
Description	Inactive ubiquitin carboxyl-terminal hydrolase 53 (Inactive ubiquitin- specific peptidase 53) (Per-hexamer repeat protein 3).

ZN496_HUMAN
θ value	5.27518 (rank : 27)	NC score	0.000369 (rank : 32)
Query Neighborhood Hits	32	Target Neighborhood Hits	743	Shared Neighborhood Hits	3
SwissProt Accessions	Q96IT1	Gene names	ZNF496
Domain Architecture	No domain graphic available
Description	Zinc finger protein 496.

MKL1_MOUSE
θ value	6.88961 (rank : 28)	NC score	0.013143 (rank : 24)
Query Neighborhood Hits	32	Target Neighborhood Hits	667	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

FOG1_HUMAN
θ value	8.99809 (rank : 29)	NC score	0.001994 (rank : 31)
Query Neighborhood Hits	32	Target Neighborhood Hits	981	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IX07	Gene names	ZFPM1, FOG1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

K1383_HUMAN
θ value	8.99809 (rank : 30)	NC score	0.015854 (rank : 20)
Query Neighborhood Hits	32	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P2G4, Q58EZ9, Q5VV83	Gene names	KIAA1383
Domain Architecture	No domain graphic available
Description	Protein KIAA1383.

LRC17_HUMAN
θ value	8.99809 (rank : 31)	NC score	0.004602 (rank : 30)
Query Neighborhood Hits	32	Target Neighborhood Hits	267	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N6Y2, Q13288, Q6UWA7, Q75MG5	Gene names	LRRC17, P37NB
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 17 precursor (p37NB).

PI5PA_MOUSE
θ value	8.99809 (rank : 32)	NC score	0.011111 (rank : 25)
Query Neighborhood Hits	32	Target Neighborhood Hits	331	Shared Neighborhood Hits	7
SwissProt Accessions	P59644	Gene names	Pib5pa
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

Hits sorted by NC score

ODPX_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	32	Target Neighborhood Hits	32	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BKZ9	Gene names	Pdhx
Domain Architecture	No domain graphic available
Description	Pyruvate dehydrogenase protein X component, mitochondrial precursor (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (Lipoyl-containing pyruvate dehydrogenase complex component X).

ODPX_HUMAN
NC score	0.992209 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	32	Target Neighborhood Hits	24	Shared Neighborhood Hits	11
SwissProt Accessions	O00330, O60221, Q96FV8, Q99783	Gene names	PDHX, PDX1
Domain Architecture
Description	Pyruvate dehydrogenase protein X component, mitochondrial precursor (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (Lipoyl-containing pyruvate dehydrogenase complex component X) (E3-binding protein) (E3BP) (proX).

ODP2_HUMAN
NC score	0.925731 (rank : 3)	θ value	1.31376e-75 (rank : 3)
Query Neighborhood Hits	32	Target Neighborhood Hits	59	Shared Neighborhood Hits	9
SwissProt Accessions	P10515, Q16783	Gene names	DLAT, DLTA
Domain Architecture
Description	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial precursor (EC 2.3.1.12) (Pyruvate dehydrogenase complex E2 subunit) (PDCE2) (E2) (Dihydrolipoamide S- acetyltransferase component of pyruvate dehydrogenase complex) (PDC- E2) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (M2 antigen complex 70 kDa subunit).

ODB2_HUMAN
NC score	0.808743 (rank : 4)	θ value	8.06329e-33 (rank : 4)
Query Neighborhood Hits	32	Target Neighborhood Hits	19	Shared Neighborhood Hits	9
SwissProt Accessions	P11182	Gene names	DBT, BCATE2
Domain Architecture
Description	Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor (EC 2.3.1.168) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) (E2) (Dihydrolipoamide branched chain transacylase) (BCKAD E2 subunit).

ODB2_MOUSE
NC score	0.802154 (rank : 5)	θ value	5.22648e-32 (rank : 5)
Query Neighborhood Hits	32	Target Neighborhood Hits	18	Shared Neighborhood Hits	9
SwissProt Accessions	P53395	Gene names	Dbt
Domain Architecture
Description	Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor (EC 2.3.1.168) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase) (E2) (Dihydrolipoamide branched chain transacylase) (BCKAD E2 subunit).

ODO2_HUMAN
NC score	0.745265 (rank : 6)	θ value	1.6852e-22 (rank : 7)
Query Neighborhood Hits	32	Target Neighborhood Hits	58	Shared Neighborhood Hits	8
SwissProt Accessions	P36957, Q9BQ32	Gene names	DLST, DLTS
Domain Architecture
Description	Dihydrolipoyllysine-residue succinyltransferase component of 2- oxoglutarate dehydrogenase complex, mitochondrial precursor (EC 2.3.1.61) (Dihydrolipoamide succinyltransferase component of 2- oxoglutarate dehydrogenase complex) (E2) (E2K).

ODO2_MOUSE
NC score	0.739085 (rank : 7)	θ value	1.99067e-23 (rank : 6)
Query Neighborhood Hits	32	Target Neighborhood Hits	85	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D2G2	Gene names	Dlst
Domain Architecture	No domain graphic available
Description	Dihydrolipoyllysine-residue succinyltransferase component of 2- oxoglutarate dehydrogenase complex, mitochondrial precursor (EC 2.3.1.61) (Dihydrolipoamide succinyltransferase component of 2- oxoglutarate dehydrogenase complex) (E2) (E2K).

RFIP1_MOUSE
NC score	0.099022 (rank : 8)	θ value	0.00509761 (rank : 8)
Query Neighborhood Hits	32	Target Neighborhood Hits	152	Shared Neighborhood Hits	3
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

MCCA_MOUSE
NC score	0.091044 (rank : 9)	θ value	0.0961366 (rank : 9)
Query Neighborhood Hits	32	Target Neighborhood Hits	18	Shared Neighborhood Hits	7
SwissProt Accessions	Q99MR8, Q3TGU0, Q9D8R2	Gene names	Mccc1, Mcca
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

MCCA_HUMAN
NC score	0.090070 (rank : 10)	θ value	0.279714 (rank : 12)
Query Neighborhood Hits	32	Target Neighborhood Hits	26	Shared Neighborhood Hits	7
SwissProt Accessions	Q96RQ3, Q59ES4, Q9H959, Q9NS97	Gene names	MCCC1, MCCA
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

COA1_HUMAN
NC score	0.053320 (rank : 11)	θ value	1.06291 (rank : 16)
Query Neighborhood Hits	32	Target Neighborhood Hits	49	Shared Neighborhood Hits	5
SwissProt Accessions	Q13085	Gene names	ACACA, ACAC, ACC1, ACCA
Domain Architecture
Description	Acetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)].

RUNX2_MOUSE
NC score	0.036490 (rank : 12)	θ value	0.813845 (rank : 15)
Query Neighborhood Hits	32	Target Neighborhood Hits	119	Shared Neighborhood Hits	4
SwissProt Accessions	Q08775, O35183, Q08776, Q9JLN0, Q9QUQ6, Q9QY29, Q9R0U4, Q9Z2J7	Gene names	Runx2, Aml3, Cbfa1, Osf2, Pebp2a
Domain Architecture
Description	Runt-related transcription factor 2 (Core-binding factor, alpha 1 subunit) (CBF-alpha 1) (Acute myeloid leukemia 3 protein) (Oncogene AML-3) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEBP2-alpha A) (PEA2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) (Osteoblast- specific transcription factor 2) (OSF-2).

RUNX2_HUMAN
NC score	0.035371 (rank : 13)	θ value	1.06291 (rank : 17)
Query Neighborhood Hits	32	Target Neighborhood Hits	103	Shared Neighborhood Hits	4
SwissProt Accessions	Q13950, O14614, O14615, O95181	Gene names	RUNX2, AML3, CBFA1, OSF2, PEBP2A
Domain Architecture
Description	Runt-related transcription factor 2 (Core-binding factor, alpha 1 subunit) (CBF-alpha 1) (Acute myeloid leukemia 3 protein) (Oncogene AML-3) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEBP2-alpha A) (PEA2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit) (Osteoblast- specific transcription factor 2) (OSF-2).

DNMT1_HUMAN
NC score	0.028882 (rank : 14)	θ value	0.62314 (rank : 14)
Query Neighborhood Hits	32	Target Neighborhood Hits	401	Shared Neighborhood Hits	2
SwissProt Accessions	P26358, Q9UHG5, Q9ULA2, Q9UMZ6	Gene names	DNMT1, AIM, DNMT
Domain Architecture
Description	DNA (cytosine-5)-methyltransferase 1 (EC 2.1.1.37) (Dnmt1) (DNA methyltransferase HsaI) (DNA MTase HsaI) (MCMT) (M.HsaI).

SAPS1_HUMAN
NC score	0.028239 (rank : 15)	θ value	0.21417 (rank : 11)
Query Neighborhood Hits	32	Target Neighborhood Hits	704	Shared Neighborhood Hits	8
SwissProt Accessions	Q9UPN7, Q504V2, Q6NVJ6, Q9BU97	Gene names	SAPS1, KIAA1115
Domain Architecture
Description	SAPS domain family member 1.

EDN3_MOUSE
NC score	0.027630 (rank : 16)	θ value	2.36792 (rank : 19)
Query Neighborhood Hits	32	Target Neighborhood Hits	61	Shared Neighborhood Hits	2
SwissProt Accessions	P48299, Q543L0	Gene names	Edn3
Domain Architecture
Description	Endothelin-3 precursor (ET-3) (Preproendothelin-3) (PPET3).

ARRB2_HUMAN
NC score	0.023551 (rank : 17)	θ value	0.62314 (rank : 13)
Query Neighborhood Hits	32	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	P32121, Q0Z8D3, Q2PP19, Q6ICT3, Q8N7Y2, Q9UEQ6	Gene names	ARRB2, ARB2, ARR2
Domain Architecture
Description	Beta-arrestin-2 (Arrestin beta 2).

MAGE1_HUMAN
NC score	0.019307 (rank : 18)	θ value	0.21417 (rank : 10)
Query Neighborhood Hits	32	Target Neighborhood Hits	1389	Shared Neighborhood Hits	11
SwissProt Accessions	Q9HCI5, Q86TG0, Q8TD92, Q9H216	Gene names	MAGEE1, HCA1, KIAA1587
Domain Architecture	No domain graphic available
Description	Melanoma-associated antigen E1 (MAGE-E1 antigen) (Hepatocellular carcinoma-associated protein 1).

EFS_MOUSE
NC score	0.019218 (rank : 19)	θ value	2.36792 (rank : 20)
Query Neighborhood Hits	32	Target Neighborhood Hits	389	Shared Neighborhood Hits	5
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

K1383_HUMAN
NC score	0.015854 (rank : 20)	θ value	8.99809 (rank : 30)
Query Neighborhood Hits	32	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P2G4, Q58EZ9, Q5VV83	Gene names	KIAA1383
Domain Architecture	No domain graphic available
Description	Protein KIAA1383.

NCOR2_HUMAN
NC score	0.014139 (rank : 21)	θ value	4.03905 (rank : 24)
Query Neighborhood Hits	32	Target Neighborhood Hits	870	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

OPT_HUMAN
NC score	0.013698 (rank : 22)	θ value	1.38821 (rank : 18)
Query Neighborhood Hits	32	Target Neighborhood Hits	255	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UBM4	Gene names	OPTC, OPT
Domain Architecture	No domain graphic available
Description	Opticin precursor (Oculoglycan).

UBP53_MOUSE
NC score	0.013431 (rank : 23)	θ value	5.27518 (rank : 26)
Query Neighborhood Hits	32	Target Neighborhood Hits	188	Shared Neighborhood Hits	3
SwissProt Accessions	P15975, Q8CB37, Q8R251	Gene names	Usp53, Phxr3
Domain Architecture	No domain graphic available
Description	Inactive ubiquitin carboxyl-terminal hydrolase 53 (Inactive ubiquitin- specific peptidase 53) (Per-hexamer repeat protein 3).

MKL1_MOUSE
NC score	0.013143 (rank : 24)	θ value	6.88961 (rank : 28)
Query Neighborhood Hits	32	Target Neighborhood Hits	667	Shared Neighborhood Hits	6
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

PI5PA_MOUSE
NC score	0.011111 (rank : 25)	θ value	8.99809 (rank : 32)
Query Neighborhood Hits	32	Target Neighborhood Hits	331	Shared Neighborhood Hits	7
SwissProt Accessions	P59644	Gene names	Pib5pa
Domain Architecture
Description	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A (EC 3.1.3.56).

UBP43_MOUSE
NC score	0.008937 (rank : 26)	θ value	5.27518 (rank : 25)
Query Neighborhood Hits	32	Target Neighborhood Hits	130	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BUM9, Q8VDP5	Gene names	Usp43
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 43 (EC 3.1.2.15) (Ubiquitin thioesterase 43) (Ubiquitin-specific-processing protease 43) (Deubiquitinating enzyme 43).

KIF2C_HUMAN
NC score	0.008807 (rank : 27)	θ value	2.36792 (rank : 21)
Query Neighborhood Hits	32	Target Neighborhood Hits	138	Shared Neighborhood Hits	2
SwissProt Accessions	Q99661, Q96C18, Q96HB8, Q9BWV8	Gene names	KIF2C, KNSL6
Domain Architecture
Description	Kinesin-like protein KIF2C (Mitotic centromere-associated kinesin) (MCAK) (Kinesin-like protein 6).

CAC1S_MOUSE
NC score	0.006866 (rank : 28)	θ value	4.03905 (rank : 22)
Query Neighborhood Hits	32	Target Neighborhood Hits	98	Shared Neighborhood Hits	2
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

FBLN2_MOUSE
NC score	0.006286 (rank : 29)	θ value	4.03905 (rank : 23)
Query Neighborhood Hits	32	Target Neighborhood Hits	505	Shared Neighborhood Hits	4
SwissProt Accessions	P37889, Q9WUI2	Gene names	Fbln2
Domain Architecture
Description	Fibulin-2 precursor.

LRC17_HUMAN
NC score	0.004602 (rank : 30)	θ value	8.99809 (rank : 31)
Query Neighborhood Hits	32	Target Neighborhood Hits	267	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N6Y2, Q13288, Q6UWA7, Q75MG5	Gene names	LRRC17, P37NB
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 17 precursor (p37NB).

FOG1_HUMAN
NC score	0.001994 (rank : 31)	θ value	8.99809 (rank : 29)
Query Neighborhood Hits	32	Target Neighborhood Hits	981	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IX07	Gene names	ZFPM1, FOG1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

ZN496_HUMAN
NC score	0.000369 (rank : 32)	θ value	5.27518 (rank : 27)
Query Neighborhood Hits	32	Target Neighborhood Hits	743	Shared Neighborhood Hits	3
SwissProt Accessions	Q96IT1	Gene names	ZNF496
Domain Architecture	No domain graphic available
Description	Zinc finger protein 496.