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Network neighborhood for query Sequence : PUR2_HUMAN

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PUR2_HUMAN
SwissProt Accessions	P22102	Gene names	GART, PRGS
Domain Architecture
Description	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PUR2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	P22102	Gene names	GART, PRGS
Domain Architecture
Description	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)].

PUR2_MOUSE
θ value	0 (rank : 2)	NC score	0.996569 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	18	Shared Neighborhood Hits	11
SwissProt Accessions	Q64737, Q6NS48	Gene names	Gart
Domain Architecture
Description	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)].

FMT_HUMAN
θ value	1.87187e-05 (rank : 3)	NC score	0.311111 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	9	Shared Neighborhood Hits	6
SwissProt Accessions	Q96DP5	Gene names	MTFMT, FMT, FMT1
Domain Architecture
Description	Methionyl-tRNA formyltransferase, mitochondrial precursor (EC 2.1.2.9) (MtFMT).

FMT_MOUSE
θ value	2.44474e-05 (rank : 4)	NC score	0.310391 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	8	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D799, Q8VE89	Gene names	Mtfmt, Fmt
Domain Architecture
Description	Methionyl-tRNA formyltransferase, mitochondrial precursor (EC 2.1.2.9) (MtFMT).

FTHFD_MOUSE
θ value	2.44474e-05 (rank : 5)	NC score	0.125350 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R0Y6	Gene names	Aldh1l1, Fthfd
Domain Architecture
Description	10-formyltetrahydrofolate dehydrogenase (EC 1.5.1.6) (10-FTHFDH) (Aldehyde dehydrogenase 1 family member L1).

FTHFD_HUMAN
θ value	0.00020696 (rank : 6)	NC score	0.120772 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	38	Shared Neighborhood Hits	6
SwissProt Accessions	O75891, Q68CS1	Gene names	ALDH1L1, FTHFD
Domain Architecture
Description	10-formyltetrahydrofolate dehydrogenase (EC 1.5.1.6) (10-FTHFDH) (Aldehyde dehydrogenase 1 family member L1).

CPSM_HUMAN
θ value	0.0330416 (rank : 7)	NC score	0.125907 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	27	Shared Neighborhood Hits	10
SwissProt Accessions	P31327, O43774, Q7Z5I5	Gene names	CPS1
Domain Architecture
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

PYR1_HUMAN
θ value	0.163984 (rank : 8)	NC score	0.085450 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	119	Shared Neighborhood Hits	9
SwissProt Accessions	P27708, Q6P0Q0	Gene names	CAD
Domain Architecture	No domain graphic available
Description	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)].

MCCA_HUMAN
θ value	0.813845 (rank : 9)	NC score	0.060409 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	Q96RQ3, Q59ES4, Q9H959, Q9NS97	Gene names	MCCC1, MCCA
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

CPSM_MOUSE
θ value	1.06291 (rank : 10)	NC score	0.108967 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	32	Shared Neighborhood Hits	10
SwissProt Accessions	Q8C196, Q6NX75	Gene names	Cps1
Domain Architecture	No domain graphic available
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

SFR14_MOUSE
θ value	1.38821 (rank : 11)	NC score	0.029734 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	238	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CH09, Q6PG19, Q80UY8, Q8BY32, Q8CFM0	Gene names	Sfrs14
Domain Architecture	No domain graphic available
Description	Putative splicing factor, arginine/serine-rich 14 (Arginine/serine- rich-splicing factor 14).

ANTOL_MOUSE
θ value	3.0926 (rank : 12)	NC score	0.031715 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D8N6	Gene names
Domain Architecture	No domain graphic available
Description	Antolefinin (Antolefinine).

CNTP3_HUMAN
θ value	3.0926 (rank : 13)	NC score	0.011401 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	195	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BZ76, Q9C0E9	Gene names	CNTNAP3, CASPR3, KIAA1714
Domain Architecture
Description	Contactin-associated protein-like 3 precursor (Cell recognition molecule Caspr3).

K2027_HUMAN
θ value	4.03905 (rank : 14)	NC score	0.022004 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	194	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZVF9, Q8IVE4	Gene names	KIAA2027
Domain Architecture	No domain graphic available
Description	Protein KIAA2027.

PCCA_MOUSE
θ value	4.03905 (rank : 15)	NC score	0.048117 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	18	Shared Neighborhood Hits	9
SwissProt Accessions	Q91ZA3, Q80VU5, Q922N3	Gene names	Pcca
Domain Architecture	No domain graphic available
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

FCRL5_HUMAN
θ value	5.27518 (rank : 16)	NC score	0.009233 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	267	Shared Neighborhood Hits	2
SwissProt Accessions	Q96RD9, Q495Q2, Q495Q4, Q5VYK9, Q6UY46	Gene names	FCRL5, FCRH5, IRTA2
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 5 precursor (Immunoglobulin receptor translocation-associated gene 2 protein) (BXMAS1) (CD307 antigen).

PCCA_HUMAN
θ value	5.27518 (rank : 17)	NC score	0.052629 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	22	Shared Neighborhood Hits	10
SwissProt Accessions	P05165, Q15979	Gene names	PCCA
Domain Architecture
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

PYC_HUMAN
θ value	5.27518 (rank : 18)	NC score	0.043671 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	25	Shared Neighborhood Hits	9
SwissProt Accessions	P11498, Q16705	Gene names	PC
Domain Architecture
Description	Pyruvate carboxylase, mitochondrial precursor (EC 6.4.1.1) (Pyruvic carboxylase) (PCB).

ADCY8_MOUSE
θ value	6.88961 (rank : 19)	NC score	0.006799 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	P97490	Gene names	Adcy8
Domain Architecture
Description	Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase).

DDX28_MOUSE
θ value	6.88961 (rank : 20)	NC score	0.005943 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	112	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CWT6, Q3TQM0	Gene names	Ddx28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).

MCCA_MOUSE
θ value	8.99809 (rank : 21)	NC score	0.051375 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	Q99MR8, Q3TGU0, Q9D8R2	Gene names	Mccc1, Mcca
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

Hits sorted by NC score

PUR2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	P22102	Gene names	GART, PRGS
Domain Architecture
Description	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)].

PUR2_MOUSE
NC score	0.996569 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	18	Shared Neighborhood Hits	11
SwissProt Accessions	Q64737, Q6NS48	Gene names	Gart
Domain Architecture
Description	Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (GARS) (Glycinamide ribonucleotide synthetase) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIRS) (Phosphoribosyl-aminoimidazole synthetase) (AIR synthase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (GART) (GAR transformylase) (5'-phosphoribosylglycinamide transformylase)].

FMT_HUMAN
NC score	0.311111 (rank : 3)	θ value	1.87187e-05 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	9	Shared Neighborhood Hits	6
SwissProt Accessions	Q96DP5	Gene names	MTFMT, FMT, FMT1
Domain Architecture
Description	Methionyl-tRNA formyltransferase, mitochondrial precursor (EC 2.1.2.9) (MtFMT).

FMT_MOUSE
NC score	0.310391 (rank : 4)	θ value	2.44474e-05 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	8	Shared Neighborhood Hits	6
SwissProt Accessions	Q9D799, Q8VE89	Gene names	Mtfmt, Fmt
Domain Architecture
Description	Methionyl-tRNA formyltransferase, mitochondrial precursor (EC 2.1.2.9) (MtFMT).

CPSM_HUMAN
NC score	0.125907 (rank : 5)	θ value	0.0330416 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	27	Shared Neighborhood Hits	10
SwissProt Accessions	P31327, O43774, Q7Z5I5	Gene names	CPS1
Domain Architecture
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

FTHFD_MOUSE
NC score	0.125350 (rank : 6)	θ value	2.44474e-05 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	36	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R0Y6	Gene names	Aldh1l1, Fthfd
Domain Architecture
Description	10-formyltetrahydrofolate dehydrogenase (EC 1.5.1.6) (10-FTHFDH) (Aldehyde dehydrogenase 1 family member L1).

FTHFD_HUMAN
NC score	0.120772 (rank : 7)	θ value	0.00020696 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	38	Shared Neighborhood Hits	6
SwissProt Accessions	O75891, Q68CS1	Gene names	ALDH1L1, FTHFD
Domain Architecture
Description	10-formyltetrahydrofolate dehydrogenase (EC 1.5.1.6) (10-FTHFDH) (Aldehyde dehydrogenase 1 family member L1).

CPSM_MOUSE
NC score	0.108967 (rank : 8)	θ value	1.06291 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	32	Shared Neighborhood Hits	10
SwissProt Accessions	Q8C196, Q6NX75	Gene names	Cps1
Domain Architecture	No domain graphic available
Description	Carbamoyl-phosphate synthase [ammonia], mitochondrial precursor (EC 6.3.4.16) (Carbamoyl-phosphate synthetase I) (CPSase I).

PYR1_HUMAN
NC score	0.085450 (rank : 9)	θ value	0.163984 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	119	Shared Neighborhood Hits	9
SwissProt Accessions	P27708, Q6P0Q0	Gene names	CAD
Domain Architecture	No domain graphic available
Description	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2); Dihydroorotase (EC 3.5.2.3)].

MCCA_HUMAN
NC score	0.060409 (rank : 10)	θ value	0.813845 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	26	Shared Neighborhood Hits	10
SwissProt Accessions	Q96RQ3, Q59ES4, Q9H959, Q9NS97	Gene names	MCCC1, MCCA
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

PCCA_HUMAN
NC score	0.052629 (rank : 11)	θ value	5.27518 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	22	Shared Neighborhood Hits	10
SwissProt Accessions	P05165, Q15979	Gene names	PCCA
Domain Architecture
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

MCCA_MOUSE
NC score	0.051375 (rank : 12)	θ value	8.99809 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	18	Shared Neighborhood Hits	10
SwissProt Accessions	Q99MR8, Q3TGU0, Q9D8R2	Gene names	Mccc1, Mcca
Domain Architecture
Description	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial precursor (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 1) (MCCase subunit alpha) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha) (3- methylcrotonyl-CoA carboxylase biotin-containing subunit).

PCCA_MOUSE
NC score	0.048117 (rank : 13)	θ value	4.03905 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	18	Shared Neighborhood Hits	9
SwissProt Accessions	Q91ZA3, Q80VU5, Q922N3	Gene names	Pcca
Domain Architecture	No domain graphic available
Description	Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase subunit alpha) (Propanoyl-CoA:carbon dioxide ligase subunit alpha).

PYC_HUMAN
NC score	0.043671 (rank : 14)	θ value	5.27518 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	25	Shared Neighborhood Hits	9
SwissProt Accessions	P11498, Q16705	Gene names	PC
Domain Architecture
Description	Pyruvate carboxylase, mitochondrial precursor (EC 6.4.1.1) (Pyruvic carboxylase) (PCB).

ANTOL_MOUSE
NC score	0.031715 (rank : 15)	θ value	3.0926 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D8N6	Gene names
Domain Architecture	No domain graphic available
Description	Antolefinin (Antolefinine).

SFR14_MOUSE
NC score	0.029734 (rank : 16)	θ value	1.38821 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	238	Shared Neighborhood Hits	2
SwissProt Accessions	Q8CH09, Q6PG19, Q80UY8, Q8BY32, Q8CFM0	Gene names	Sfrs14
Domain Architecture	No domain graphic available
Description	Putative splicing factor, arginine/serine-rich 14 (Arginine/serine- rich-splicing factor 14).

K2027_HUMAN
NC score	0.022004 (rank : 17)	θ value	4.03905 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	194	Shared Neighborhood Hits	2
SwissProt Accessions	Q6ZVF9, Q8IVE4	Gene names	KIAA2027
Domain Architecture	No domain graphic available
Description	Protein KIAA2027.

CNTP3_HUMAN
NC score	0.011401 (rank : 18)	θ value	3.0926 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	195	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BZ76, Q9C0E9	Gene names	CNTNAP3, CASPR3, KIAA1714
Domain Architecture
Description	Contactin-associated protein-like 3 precursor (Cell recognition molecule Caspr3).

FCRL5_HUMAN
NC score	0.009233 (rank : 19)	θ value	5.27518 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	267	Shared Neighborhood Hits	2
SwissProt Accessions	Q96RD9, Q495Q2, Q495Q4, Q5VYK9, Q6UY46	Gene names	FCRL5, FCRH5, IRTA2
Domain Architecture	No domain graphic available
Description	Fc receptor-like protein 5 precursor (Immunoglobulin receptor translocation-associated gene 2 protein) (BXMAS1) (CD307 antigen).

ADCY8_MOUSE
NC score	0.006799 (rank : 20)	θ value	6.88961 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	P97490	Gene names	Adcy8
Domain Architecture
Description	Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase).

DDX28_MOUSE
NC score	0.005943 (rank : 21)	θ value	6.88961 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	112	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CWT6, Q3TQM0	Gene names	Ddx28
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX28 (EC 3.6.1.-) (Mitochondrial DEAD box protein 28).