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Network neighborhood for query Sequence : OSBL3_HUMAN

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OSBL3_HUMAN
SwissProt Accessions	Q9H4L5, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9UED6	Gene names	OSBPL3, KIAA0704, ORP3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

OSBL3_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	93	Target Neighborhood Hits	93	Shared Neighborhood Hits	93
SwissProt Accessions	Q9H4L5, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9UED6	Gene names	OSBPL3, KIAA0704, ORP3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

OSBL3_MOUSE
θ value	0 (rank : 2)	NC score	0.995133 (rank : 2)
Query Neighborhood Hits	93	Target Neighborhood Hits	86	Shared Neighborhood Hits	59
SwissProt Accessions	Q9DBS9	Gene names	Osbpl3, Orp3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

OSBL6_HUMAN
θ value	0 (rank : 3)	NC score	0.983457 (rank : 3)
Query Neighborhood Hits	93	Target Neighborhood Hits	101	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BZF3, Q7Z4Q1, Q96SR1	Gene names	OSBPL6, ORP6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

OSBL6_MOUSE
θ value	0 (rank : 4)	NC score	0.981870 (rank : 5)
Query Neighborhood Hits	93	Target Neighborhood Hits	105	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BXR9, Q8BYW2	Gene names	Osbpl6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

OSBL7_HUMAN
θ value	0 (rank : 5)	NC score	0.982253 (rank : 4)
Query Neighborhood Hits	93	Target Neighborhood Hits	71	Shared Neighborhood Hits	38
SwissProt Accessions	Q9BZF2	Gene names	OSBPL7, ORP7
Domain Architecture
Description	Oxysterol-binding protein-related protein 7 (OSBP-related protein 7) (ORP-7).

OSBP1_HUMAN
θ value	4.67263e-73 (rank : 6)	NC score	0.887020 (rank : 10)
Query Neighborhood Hits	93	Target Neighborhood Hits	180	Shared Neighborhood Hits	51
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

OSBL1_HUMAN
θ value	7.97034e-73 (rank : 7)	NC score	0.620600 (rank : 17)
Query Neighborhood Hits	93	Target Neighborhood Hits	368	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BXW6, Q9BZF5, Q9NW87	Gene names	OSBPL1A, ORP1, OSBP8, OSBPL1
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

OSBL1_MOUSE
θ value	1.7756e-72 (rank : 8)	NC score	0.634199 (rank : 16)
Query Neighborhood Hits	93	Target Neighborhood Hits	336	Shared Neighborhood Hits	34
SwissProt Accessions	Q91XL9, O88318, Q3TH97, Q673L8, Q6DFU6	Gene names	Osbpl1a, Orp1, Orp1a
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

OSBP2_HUMAN
θ value	5.71191e-71 (rank : 9)	NC score	0.890017 (rank : 9)
Query Neighborhood Hits	93	Target Neighborhood Hits	154	Shared Neighborhood Hits	45
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

OSBP2_MOUSE
θ value	1.66191e-70 (rank : 10)	NC score	0.892414 (rank : 8)
Query Neighborhood Hits	93	Target Neighborhood Hits	150	Shared Neighborhood Hits	45
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

OSBL2_HUMAN
θ value	4.68348e-65 (rank : 11)	NC score	0.911433 (rank : 6)
Query Neighborhood Hits	93	Target Neighborhood Hits	23	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H1P3, Q9BZB1, Q9Y4B8	Gene names	OSBPL2, KIAA0772, ORP2
Domain Architecture
Description	Oxysterol-binding protein-related protein 2 (OSBP-related protein 2) (ORP-2).

OSBL2_MOUSE
θ value	1.15626e-55 (rank : 12)	NC score	0.905521 (rank : 7)
Query Neighborhood Hits	93	Target Neighborhood Hits	22	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BX94, Q3TCK8, Q8R0H8	Gene names	Osbpl2
Domain Architecture
Description	Oxysterol-binding protein-related protein 2 (OSBP-related protein 2) (ORP-2).

OSBL5_HUMAN
θ value	5.07402e-19 (rank : 13)	NC score	0.682643 (rank : 11)
Query Neighborhood Hits	93	Target Neighborhood Hits	117	Shared Neighborhood Hits	29
SwissProt Accessions	Q9H0X9, Q9BZB0, Q9P1Z4	Gene names	OSBPL5, KIAA1534, ORP5
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5).

OSBL8_HUMAN
θ value	5.60996e-18 (rank : 14)	NC score	0.663665 (rank : 13)
Query Neighborhood Hits	93	Target Neighborhood Hits	289	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BZF1, Q8WXP8, Q9P277	Gene names	OSBPL8, KIAA1451, ORP8, OSBP10
Domain Architecture
Description	Oxysterol-binding protein-related protein 8 (OSBP-related protein 8) (ORP-8).

OSBL5_MOUSE
θ value	1.24977e-17 (rank : 15)	NC score	0.681702 (rank : 12)
Query Neighborhood Hits	93	Target Neighborhood Hits	77	Shared Neighborhood Hits	31
SwissProt Accessions	Q9ER64, Q8R510, Q99NF5	Gene names	Osbpl5, Obph1, Osbp2
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5) (Oxysterol-binding protein homolog 1).

OSBL9_HUMAN
θ value	1.29331e-14 (rank : 16)	NC score	0.645827 (rank : 15)
Query Neighborhood Hits	93	Target Neighborhood Hits	138	Shared Neighborhood Hits	44
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

OSB10_HUMAN
θ value	1.09485e-13 (rank : 17)	NC score	0.649243 (rank : 14)
Query Neighborhood Hits	93	Target Neighborhood Hits	55	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BXB5, Q9BTU5	Gene names	OSBPL10, ORP10, OSBP9
Domain Architecture
Description	Oxysterol-binding protein-related protein 10 (OSBP-related protein 10) (ORP-10).

OSB11_MOUSE
θ value	1.02475e-11 (rank : 18)	NC score	0.619331 (rank : 18)
Query Neighborhood Hits	93	Target Neighborhood Hits	71	Shared Neighborhood Hits	31
SwissProt Accessions	Q8CI95	Gene names	Osbpl11
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

OSB11_HUMAN
θ value	5.62301e-10 (rank : 19)	NC score	0.608482 (rank : 19)
Query Neighborhood Hits	93	Target Neighborhood Hits	60	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BXB4	Gene names	OSBPL11, ORP11, OSBP12
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

DDEF2_HUMAN
θ value	0.000602161 (rank : 20)	NC score	0.102741 (rank : 25)
Query Neighborhood Hits	93	Target Neighborhood Hits	599	Shared Neighborhood Hits	30
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

C43BP_MOUSE
θ value	0.00102713 (rank : 21)	NC score	0.328384 (rank : 23)
Query Neighborhood Hits	93	Target Neighborhood Hits	91	Shared Neighborhood Hits	39
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

DDEF1_MOUSE
θ value	0.00134147 (rank : 22)	NC score	0.139700 (rank : 24)
Query Neighborhood Hits	93	Target Neighborhood Hits	592	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_MOUSE
θ value	0.00175202 (rank : 23)	NC score	0.102201 (rank : 26)
Query Neighborhood Hits	93	Target Neighborhood Hits	625	Shared Neighborhood Hits	32
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

C43BP_HUMAN
θ value	0.00298849 (rank : 24)	NC score	0.331375 (rank : 22)
Query Neighborhood Hits	93	Target Neighborhood Hits	87	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

CYH3_HUMAN
θ value	0.0148317 (rank : 25)	NC score	0.083663 (rank : 32)
Query Neighborhood Hits	93	Target Neighborhood Hits	137	Shared Neighborhood Hits	32
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

FBX28_HUMAN
θ value	0.0193708 (rank : 26)	NC score	0.063869 (rank : 50)
Query Neighborhood Hits	93	Target Neighborhood Hits	110	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NVF7, O75070	Gene names	FBXO28, KIAA0483
Domain Architecture	No domain graphic available
Description	F-box only protein 28.

DGKH_HUMAN
θ value	0.0563607 (rank : 27)	NC score	0.038679 (rank : 64)
Query Neighborhood Hits	93	Target Neighborhood Hits	255	Shared Neighborhood Hits	26
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

MYRIP_MOUSE
θ value	0.0563607 (rank : 28)	NC score	0.029982 (rank : 69)
Query Neighborhood Hits	93	Target Neighborhood Hits	207	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

DDFL1_HUMAN
θ value	0.0736092 (rank : 29)	NC score	0.090027 (rank : 29)
Query Neighborhood Hits	93	Target Neighborhood Hits	353	Shared Neighborhood Hits	25
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

MYO10_HUMAN
θ value	0.0736092 (rank : 30)	NC score	0.053310 (rank : 58)
Query Neighborhood Hits	93	Target Neighborhood Hits	920	Shared Neighborhood Hits	55
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

CYH2_HUMAN
θ value	0.0961366 (rank : 31)	NC score	0.083231 (rank : 33)
Query Neighborhood Hits	93	Target Neighborhood Hits	175	Shared Neighborhood Hits	37
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	0.0961366 (rank : 32)	NC score	0.083183 (rank : 34)
Query Neighborhood Hits	93	Target Neighborhood Hits	171	Shared Neighborhood Hits	37
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

MTMRD_HUMAN
θ value	0.125558 (rank : 33)	NC score	0.078981 (rank : 37)
Query Neighborhood Hits	93	Target Neighborhood Hits	135	Shared Neighborhood Hits	40
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

PKHA3_HUMAN
θ value	0.125558 (rank : 34)	NC score	0.347549 (rank : 21)
Query Neighborhood Hits	93	Target Neighborhood Hits	66	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

DDFL1_MOUSE
θ value	0.163984 (rank : 35)	NC score	0.088523 (rank : 31)
Query Neighborhood Hits	93	Target Neighborhood Hits	324	Shared Neighborhood Hits	22
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

PKHA3_MOUSE
θ value	0.163984 (rank : 36)	NC score	0.353631 (rank : 20)
Query Neighborhood Hits	93	Target Neighborhood Hits	67	Shared Neighborhood Hits	33
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

CYH3_MOUSE
θ value	0.21417 (rank : 37)	NC score	0.088847 (rank : 30)
Query Neighborhood Hits	93	Target Neighborhood Hits	148	Shared Neighborhood Hits	38
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

RRBP1_HUMAN
θ value	0.21417 (rank : 38)	NC score	0.013430 (rank : 79)
Query Neighborhood Hits	93	Target Neighborhood Hits	1306	Shared Neighborhood Hits	22
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

CYH1_HUMAN
θ value	0.279714 (rank : 39)	NC score	0.082213 (rank : 35)
Query Neighborhood Hits	93	Target Neighborhood Hits	184	Shared Neighborhood Hits	38
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
θ value	0.365318 (rank : 40)	NC score	0.080871 (rank : 36)
Query Neighborhood Hits	93	Target Neighborhood Hits	176	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

PLEC1_HUMAN
θ value	0.47712 (rank : 41)	NC score	0.009045 (rank : 87)
Query Neighborhood Hits	93	Target Neighborhood Hits	1326	Shared Neighborhood Hits	27
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

CLMN_HUMAN
θ value	0.62314 (rank : 42)	NC score	0.013424 (rank : 80)
Query Neighborhood Hits	93	Target Neighborhood Hits	205	Shared Neighborhood Hits	6
SwissProt Accessions	Q96JQ2, Q9H713, Q9HA23, Q9HA57, Q9UFP4, Q9ULN2	Gene names	CLMN, KIAA1188
Domain Architecture
Description	Calmin.

TBCD2_HUMAN
θ value	0.62314 (rank : 43)	NC score	0.063990 (rank : 49)
Query Neighborhood Hits	93	Target Neighborhood Hits	419	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

NSD1_MOUSE
θ value	0.813845 (rank : 44)	NC score	0.013654 (rank : 77)
Query Neighborhood Hits	93	Target Neighborhood Hits	472	Shared Neighborhood Hits	9
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

PKHA1_HUMAN
θ value	0.813845 (rank : 45)	NC score	0.072017 (rank : 40)
Query Neighborhood Hits	93	Target Neighborhood Hits	127	Shared Neighborhood Hits	37
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

EMSY_HUMAN
θ value	1.06291 (rank : 46)	NC score	0.020843 (rank : 72)
Query Neighborhood Hits	93	Target Neighborhood Hits	296	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z589, Q4G109, Q8NBU6, Q8TE50, Q9H8I9, Q9NRH0	Gene names	EMSY, C11orf30
Domain Architecture
Description	Protein EMSY.

GAB2_HUMAN
θ value	1.06291 (rank : 47)	NC score	0.066043 (rank : 45)
Query Neighborhood Hits	93	Target Neighborhood Hits	188	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

IP3KC_MOUSE
θ value	1.06291 (rank : 48)	NC score	0.030887 (rank : 68)
Query Neighborhood Hits	93	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TS72, Q3U384	Gene names	Itpkc
Domain Architecture	No domain graphic available
Description	Inositol-trisphosphate 3-kinase C (EC 2.7.1.127) (Inositol 1,4,5- trisphosphate 3-kinase C) (IP3K-C).

STX12_MOUSE
θ value	1.06291 (rank : 49)	NC score	0.018369 (rank : 73)
Query Neighborhood Hits	93	Target Neighborhood Hits	283	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ER00, Q3UIV9, Q921T9	Gene names	Stx12
Domain Architecture
Description	Syntaxin-12.

TARA_HUMAN
θ value	1.06291 (rank : 50)	NC score	0.035579 (rank : 66)
Query Neighborhood Hits	93	Target Neighborhood Hits	1626	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TARA_MOUSE
θ value	1.06291 (rank : 51)	NC score	0.057829 (rank : 56)
Query Neighborhood Hits	93	Target Neighborhood Hits	1133	Shared Neighborhood Hits	48
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

FLIP1_MOUSE
θ value	1.38821 (rank : 52)	NC score	0.010672 (rank : 84)
Query Neighborhood Hits	93	Target Neighborhood Hits	1176	Shared Neighborhood Hits	24
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

GAB1_HUMAN
θ value	1.38821 (rank : 53)	NC score	0.049647 (rank : 62)
Query Neighborhood Hits	93	Target Neighborhood Hits	279	Shared Neighborhood Hits	27
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

CENB5_HUMAN
θ value	1.81305 (rank : 54)	NC score	0.064954 (rank : 47)
Query Neighborhood Hits	93	Target Neighborhood Hits	395	Shared Neighborhood Hits	43
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CYH4_MOUSE
θ value	1.81305 (rank : 55)	NC score	0.097130 (rank : 27)
Query Neighborhood Hits	93	Target Neighborhood Hits	134	Shared Neighborhood Hits	38
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

GAB1_MOUSE
θ value	1.81305 (rank : 56)	NC score	0.048246 (rank : 63)
Query Neighborhood Hits	93	Target Neighborhood Hits	233	Shared Neighborhood Hits	24
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

PKHA2_HUMAN
θ value	1.81305 (rank : 57)	NC score	0.071798 (rank : 41)
Query Neighborhood Hits	93	Target Neighborhood Hits	119	Shared Neighborhood Hits	34
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

RHG25_HUMAN
θ value	1.81305 (rank : 58)	NC score	0.063137 (rank : 52)
Query Neighborhood Hits	93	Target Neighborhood Hits	550	Shared Neighborhood Hits	49
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_MOUSE
θ value	1.81305 (rank : 59)	NC score	0.063538 (rank : 51)
Query Neighborhood Hits	93	Target Neighborhood Hits	492	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

SPTA2_HUMAN
θ value	1.81305 (rank : 60)	NC score	0.009414 (rank : 85)
Query Neighborhood Hits	93	Target Neighborhood Hits	888	Shared Neighborhood Hits	20
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

FARP1_HUMAN
θ value	2.36792 (rank : 61)	NC score	0.028442 (rank : 70)
Query Neighborhood Hits	93	Target Neighborhood Hits	241	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

CYH4_HUMAN
θ value	3.0926 (rank : 62)	NC score	0.095139 (rank : 28)
Query Neighborhood Hits	93	Target Neighborhood Hits	135	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

FLIP1_HUMAN
θ value	3.0926 (rank : 63)	NC score	0.008578 (rank : 88)
Query Neighborhood Hits	93	Target Neighborhood Hits	1405	Shared Neighborhood Hits	27
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

IDD_HUMAN
θ value	3.0926 (rank : 64)	NC score	0.010940 (rank : 83)
Query Neighborhood Hits	93	Target Neighborhood Hits	127	Shared Neighborhood Hits	2
SwissProt Accessions	P98153	Gene names	DGCR2, IDD, KIAA0163
Domain Architecture
Description	Integral membrane protein DGCR2/IDD precursor.

PKHA1_MOUSE
θ value	3.0926 (rank : 65)	NC score	0.062730 (rank : 53)
Query Neighborhood Hits	93	Target Neighborhood Hits	120	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

RAI14_HUMAN
θ value	3.0926 (rank : 66)	NC score	0.024638 (rank : 71)
Query Neighborhood Hits	93	Target Neighborhood Hits	1367	Shared Neighborhood Hits	30
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

SPAT7_HUMAN
θ value	3.0926 (rank : 67)	NC score	0.032721 (rank : 67)
Query Neighborhood Hits	93	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q9P0W8, Q8WX30, Q96HF3, Q9H0X0, Q9P0W7	Gene names	SPATA7, HSD3
Domain Architecture	No domain graphic available
Description	Spermatogenesis-associated protein 7 (Spermatogenesis-associated protein HSD3) (HSD-3.1).

ANR26_HUMAN
θ value	4.03905 (rank : 68)	NC score	0.017490 (rank : 74)
Query Neighborhood Hits	93	Target Neighborhood Hits	1614	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

LEO1_HUMAN
θ value	4.03905 (rank : 69)	NC score	0.006591 (rank : 93)
Query Neighborhood Hits	93	Target Neighborhood Hits	958	Shared Neighborhood Hits	12
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

NPHP3_MOUSE
θ value	4.03905 (rank : 70)	NC score	0.009341 (rank : 86)
Query Neighborhood Hits	93	Target Neighborhood Hits	335	Shared Neighborhood Hits	12
SwissProt Accessions	Q7TNH6, Q69Z39, Q8C798, Q8C7Z3, Q9D6D1	Gene names	Nphp3, Kiaa2000
Domain Architecture	No domain graphic available
Description	Nephrocystin-3.

PRDM2_HUMAN
θ value	4.03905 (rank : 71)	NC score	0.008107 (rank : 90)
Query Neighborhood Hits	93	Target Neighborhood Hits	1135	Shared Neighborhood Hits	10
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

ST18_MOUSE
θ value	4.03905 (rank : 72)	NC score	0.007811 (rank : 91)
Query Neighborhood Hits	93	Target Neighborhood Hits	248	Shared Neighborhood Hits	10
SwissProt Accessions	Q80TY4, Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q811B4, Q8K098	Gene names	St18, Kiaa0535
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity protein 18.

STX12_HUMAN
θ value	4.03905 (rank : 73)	NC score	0.015276 (rank : 76)
Query Neighborhood Hits	93	Target Neighborhood Hits	226	Shared Neighborhood Hits	11
SwissProt Accessions	Q86Y82, O95564	Gene names	STX12
Domain Architecture
Description	Syntaxin-12.

CREB3_MOUSE
θ value	5.27518 (rank : 74)	NC score	0.011520 (rank : 81)
Query Neighborhood Hits	93	Target Neighborhood Hits	97	Shared Neighborhood Hits	6
SwissProt Accessions	Q61817, Q99M21, Q9CVK9	Gene names	Creb3, Lzip
Domain Architecture	No domain graphic available
Description	Cyclic AMP-responsive element-binding protein 3 (Transcription factor LZIP).

EMSY_MOUSE
θ value	5.27518 (rank : 75)	NC score	0.016781 (rank : 75)
Query Neighborhood Hits	93	Target Neighborhood Hits	294	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BMB0, Q5FWK5, Q80XU1, Q8VDW9	Gene names	Emsy
Domain Architecture
Description	Protein EMSY.

GCC2_MOUSE
θ value	5.27518 (rank : 76)	NC score	0.011150 (rank : 82)
Query Neighborhood Hits	93	Target Neighborhood Hits	1619	Shared Neighborhood Hits	36
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

SIA7C_HUMAN
θ value	5.27518 (rank : 77)	NC score	0.007001 (rank : 92)
Query Neighborhood Hits	93	Target Neighborhood Hits	38	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NDV1, Q6UX29, Q8N259	Gene names	ST6GALNAC3, SIAT7C
Domain Architecture
Description	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 (EC 2.4.99.-) (GalNAc alpha-2,6-sialyltransferase III) (ST6GalNAc III) (Sialyltransferase 7C) (STY).

GOGB1_HUMAN
θ value	6.88961 (rank : 78)	NC score	0.013569 (rank : 78)
Query Neighborhood Hits	93	Target Neighborhood Hits	2297	Shared Neighborhood Hits	41
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

K2C5_HUMAN
θ value	6.88961 (rank : 79)	NC score	0.002674 (rank : 101)
Query Neighborhood Hits	93	Target Neighborhood Hits	506	Shared Neighborhood Hits	13
SwissProt Accessions	P13647, Q6PI71, Q6UBJ0, Q8TA91	Gene names	KRT5
Domain Architecture
Description	Keratin, type II cytoskeletal 5 (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (58 kDa cytokeratin).

PKHA2_MOUSE
θ value	6.88961 (rank : 80)	NC score	0.077238 (rank : 38)
Query Neighborhood Hits	93	Target Neighborhood Hits	116	Shared Neighborhood Hits	34
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

RGS3_HUMAN
θ value	6.88961 (rank : 81)	NC score	0.002882 (rank : 100)
Query Neighborhood Hits	93	Target Neighborhood Hits	1375	Shared Neighborhood Hits	13
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

RGS3_MOUSE
θ value	6.88961 (rank : 82)	NC score	0.003988 (rank : 97)
Query Neighborhood Hits	93	Target Neighborhood Hits	1621	Shared Neighborhood Hits	12
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

SEM4B_MOUSE
θ value	6.88961 (rank : 83)	NC score	0.003335 (rank : 98)
Query Neighborhood Hits	93	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	Q62179, Q4PKI6, Q69ZB7	Gene names	Sema4b, Kiaa1745, Semac, SemC
Domain Architecture	No domain graphic available
Description	Semaphorin-4B precursor (Semaphorin C) (Sema C).

SLAF6_MOUSE
θ value	6.88961 (rank : 84)	NC score	0.008472 (rank : 89)
Query Neighborhood Hits	93	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ET39, Q9ET40	Gene names	Slamf6, Ly108
Domain Architecture	No domain graphic available
Description	SLAM family member 6 precursor (Lymphocyte antigen 108).

SWP70_MOUSE
θ value	6.88961 (rank : 85)	NC score	0.069880 (rank : 42)
Query Neighborhood Hits	93	Target Neighborhood Hits	1097	Shared Neighborhood Hits	60
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

ARTS1_HUMAN
θ value	8.99809 (rank : 86)	NC score	0.004893 (rank : 95)
Query Neighborhood Hits	93	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZ08, O60278, Q6UWY6, Q8NEL4, Q8TAD0, Q9UHF8, Q9UKY2	Gene names	ARTS1, APPILS, KIAA0525
Domain Architecture
Description	Adipocyte-derived leucine aminopeptidase precursor (EC 3.4.11.-) (A- LAP) (ARTS-1) (Aminopeptidase PILS) (Puromycin-insensitive leucyl- specific aminopeptidase) (PILS-AP) (Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator).

K2C6B_HUMAN
θ value	8.99809 (rank : 87)	NC score	0.002432 (rank : 103)
Query Neighborhood Hits	93	Target Neighborhood Hits	526	Shared Neighborhood Hits	18
SwissProt Accessions	P04259, P48669	Gene names	KRT6B, K6B
Domain Architecture
Description	Keratin, type II cytoskeletal 6B (Cytokeratin-6B) (CK 6B) (K6b keratin).

K2C6E_HUMAN
θ value	8.99809 (rank : 88)	NC score	0.002488 (rank : 102)
Query Neighborhood Hits	93	Target Neighborhood Hits	516	Shared Neighborhood Hits	17
SwissProt Accessions	P48668, Q7RTN9	Gene names	KRT6E
Domain Architecture
Description	Keratin, type II cytoskeletal 6E (Cytokeratin-6E) (CK 6E) (K6e keratin) (Keratin K6h).

MYPT2_HUMAN
θ value	8.99809 (rank : 89)	NC score	0.036407 (rank : 65)
Query Neighborhood Hits	93	Target Neighborhood Hits	707	Shared Neighborhood Hits	25
SwissProt Accessions	O60237, Q8N179, Q9HCB7, Q9HCB8	Gene names	PPP1R12B, MYPT2
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase- targeting subunit 2) (Myosin phosphatase target subunit 2).

NOP56_HUMAN
θ value	8.99809 (rank : 90)	NC score	0.006168 (rank : 94)
Query Neighborhood Hits	93	Target Neighborhood Hits	95	Shared Neighborhood Hits	3
SwissProt Accessions	O00567, Q9NQ05	Gene names	NOL5A, NOP56
Domain Architecture
Description	Nucleolar protein Nop56 (Nucleolar protein 5A).

PER2_HUMAN
θ value	8.99809 (rank : 91)	NC score	0.004073 (rank : 96)
Query Neighborhood Hits	93	Target Neighborhood Hits	170	Shared Neighborhood Hits	4
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

SEM4B_HUMAN
θ value	8.99809 (rank : 92)	NC score	0.003024 (rank : 99)
Query Neighborhood Hits	93	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NPR2, Q6UXE3, Q8WVP9, Q96FK5, Q9C0B8, Q9H691, Q9NPM8, Q9NPN0	Gene names	SEMA4B, KIAA1745
Domain Architecture
Description	Semaphorin-4B precursor.

SWP70_HUMAN
θ value	8.99809 (rank : 93)	NC score	0.072960 (rank : 39)
Query Neighborhood Hits	93	Target Neighborhood Hits	973	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

CENB1_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.062043 (rank : 55)
Query Neighborhood Hits	93	Target Neighborhood Hits	383	Shared Neighborhood Hits	41
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

DAPP1_MOUSE
θ value	θ > 10 (rank : 95)	NC score	0.052672 (rank : 59)
Query Neighborhood Hits	93	Target Neighborhood Hits	225	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

GAB2_MOUSE
θ value	θ > 10 (rank : 96)	NC score	0.066296 (rank : 44)
Query Neighborhood Hits	93	Target Neighborhood Hits	220	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

PKHA4_HUMAN
θ value	θ > 10 (rank : 97)	NC score	0.050587 (rank : 61)
Query Neighborhood Hits	93	Target Neighborhood Hits	283	Shared Neighborhood Hits	31
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA6_HUMAN
θ value	θ > 10 (rank : 98)	NC score	0.068576 (rank : 43)
Query Neighborhood Hits	93	Target Neighborhood Hits	556	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
θ value	θ > 10 (rank : 99)	NC score	0.062194 (rank : 54)
Query Neighborhood Hits	93	Target Neighborhood Hits	591	Shared Neighborhood Hits	45
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PLEK2_HUMAN
θ value	θ > 10 (rank : 100)	NC score	0.064262 (rank : 48)
Query Neighborhood Hits	93	Target Neighborhood Hits	101	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_MOUSE
θ value	θ > 10 (rank : 101)	NC score	0.065541 (rank : 46)
Query Neighborhood Hits	93	Target Neighborhood Hits	96	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PLEK_HUMAN
θ value	θ > 10 (rank : 102)	NC score	0.052533 (rank : 60)
Query Neighborhood Hits	93	Target Neighborhood Hits	110	Shared Neighborhood Hits	33
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PLEK_MOUSE
θ value	θ > 10 (rank : 103)	NC score	0.054484 (rank : 57)
Query Neighborhood Hits	93	Target Neighborhood Hits	109	Shared Neighborhood Hits	32
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

Hits sorted by NC score

OSBL3_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	93	Target Neighborhood Hits	93	Shared Neighborhood Hits	93
SwissProt Accessions	Q9H4L5, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9UED6	Gene names	OSBPL3, KIAA0704, ORP3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

OSBL3_MOUSE
NC score	0.995133 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	93	Target Neighborhood Hits	86	Shared Neighborhood Hits	59
SwissProt Accessions	Q9DBS9	Gene names	Osbpl3, Orp3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

OSBL6_HUMAN
NC score	0.983457 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	93	Target Neighborhood Hits	101	Shared Neighborhood Hits	39
SwissProt Accessions	Q9BZF3, Q7Z4Q1, Q96SR1	Gene names	OSBPL6, ORP6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

OSBL7_HUMAN
NC score	0.982253 (rank : 4)	θ value	0 (rank : 5)
Query Neighborhood Hits	93	Target Neighborhood Hits	71	Shared Neighborhood Hits	38
SwissProt Accessions	Q9BZF2	Gene names	OSBPL7, ORP7
Domain Architecture
Description	Oxysterol-binding protein-related protein 7 (OSBP-related protein 7) (ORP-7).

OSBL6_MOUSE
NC score	0.981870 (rank : 5)	θ value	0 (rank : 4)
Query Neighborhood Hits	93	Target Neighborhood Hits	105	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BXR9, Q8BYW2	Gene names	Osbpl6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

OSBL2_HUMAN
NC score	0.911433 (rank : 6)	θ value	4.68348e-65 (rank : 11)
Query Neighborhood Hits	93	Target Neighborhood Hits	23	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H1P3, Q9BZB1, Q9Y4B8	Gene names	OSBPL2, KIAA0772, ORP2
Domain Architecture
Description	Oxysterol-binding protein-related protein 2 (OSBP-related protein 2) (ORP-2).

OSBL2_MOUSE
NC score	0.905521 (rank : 7)	θ value	1.15626e-55 (rank : 12)
Query Neighborhood Hits	93	Target Neighborhood Hits	22	Shared Neighborhood Hits	19
SwissProt Accessions	Q8BX94, Q3TCK8, Q8R0H8	Gene names	Osbpl2
Domain Architecture
Description	Oxysterol-binding protein-related protein 2 (OSBP-related protein 2) (ORP-2).

OSBP2_MOUSE
NC score	0.892414 (rank : 8)	θ value	1.66191e-70 (rank : 10)
Query Neighborhood Hits	93	Target Neighborhood Hits	150	Shared Neighborhood Hits	45
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

OSBP2_HUMAN
NC score	0.890017 (rank : 9)	θ value	5.71191e-71 (rank : 9)
Query Neighborhood Hits	93	Target Neighborhood Hits	154	Shared Neighborhood Hits	45
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

OSBP1_HUMAN
NC score	0.887020 (rank : 10)	θ value	4.67263e-73 (rank : 6)
Query Neighborhood Hits	93	Target Neighborhood Hits	180	Shared Neighborhood Hits	51
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

OSBL5_HUMAN
NC score	0.682643 (rank : 11)	θ value	5.07402e-19 (rank : 13)
Query Neighborhood Hits	93	Target Neighborhood Hits	117	Shared Neighborhood Hits	29
SwissProt Accessions	Q9H0X9, Q9BZB0, Q9P1Z4	Gene names	OSBPL5, KIAA1534, ORP5
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5).

OSBL5_MOUSE
NC score	0.681702 (rank : 12)	θ value	1.24977e-17 (rank : 15)
Query Neighborhood Hits	93	Target Neighborhood Hits	77	Shared Neighborhood Hits	31
SwissProt Accessions	Q9ER64, Q8R510, Q99NF5	Gene names	Osbpl5, Obph1, Osbp2
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5) (Oxysterol-binding protein homolog 1).

OSBL8_HUMAN
NC score	0.663665 (rank : 13)	θ value	5.60996e-18 (rank : 14)
Query Neighborhood Hits	93	Target Neighborhood Hits	289	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BZF1, Q8WXP8, Q9P277	Gene names	OSBPL8, KIAA1451, ORP8, OSBP10
Domain Architecture
Description	Oxysterol-binding protein-related protein 8 (OSBP-related protein 8) (ORP-8).

OSB10_HUMAN
NC score	0.649243 (rank : 14)	θ value	1.09485e-13 (rank : 17)
Query Neighborhood Hits	93	Target Neighborhood Hits	55	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BXB5, Q9BTU5	Gene names	OSBPL10, ORP10, OSBP9
Domain Architecture
Description	Oxysterol-binding protein-related protein 10 (OSBP-related protein 10) (ORP-10).

OSBL9_HUMAN
NC score	0.645827 (rank : 15)	θ value	1.29331e-14 (rank : 16)
Query Neighborhood Hits	93	Target Neighborhood Hits	138	Shared Neighborhood Hits	44
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

OSBL1_MOUSE
NC score	0.634199 (rank : 16)	θ value	1.7756e-72 (rank : 8)
Query Neighborhood Hits	93	Target Neighborhood Hits	336	Shared Neighborhood Hits	34
SwissProt Accessions	Q91XL9, O88318, Q3TH97, Q673L8, Q6DFU6	Gene names	Osbpl1a, Orp1, Orp1a
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

OSBL1_HUMAN
NC score	0.620600 (rank : 17)	θ value	7.97034e-73 (rank : 7)
Query Neighborhood Hits	93	Target Neighborhood Hits	368	Shared Neighborhood Hits	36
SwissProt Accessions	Q9BXW6, Q9BZF5, Q9NW87	Gene names	OSBPL1A, ORP1, OSBP8, OSBPL1
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

OSB11_MOUSE
NC score	0.619331 (rank : 18)	θ value	1.02475e-11 (rank : 18)
Query Neighborhood Hits	93	Target Neighborhood Hits	71	Shared Neighborhood Hits	31
SwissProt Accessions	Q8CI95	Gene names	Osbpl11
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

OSB11_HUMAN
NC score	0.608482 (rank : 19)	θ value	5.62301e-10 (rank : 19)
Query Neighborhood Hits	93	Target Neighborhood Hits	60	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BXB4	Gene names	OSBPL11, ORP11, OSBP12
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

PKHA3_MOUSE
NC score	0.353631 (rank : 20)	θ value	0.163984 (rank : 36)
Query Neighborhood Hits	93	Target Neighborhood Hits	67	Shared Neighborhood Hits	33
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PKHA3_HUMAN
NC score	0.347549 (rank : 21)	θ value	0.125558 (rank : 34)
Query Neighborhood Hits	93	Target Neighborhood Hits	66	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

C43BP_HUMAN
NC score	0.331375 (rank : 22)	θ value	0.00298849 (rank : 24)
Query Neighborhood Hits	93	Target Neighborhood Hits	87	Shared Neighborhood Hits	37
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

C43BP_MOUSE
NC score	0.328384 (rank : 23)	θ value	0.00102713 (rank : 21)
Query Neighborhood Hits	93	Target Neighborhood Hits	91	Shared Neighborhood Hits	39
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

DDEF1_MOUSE
NC score	0.139700 (rank : 24)	θ value	0.00134147 (rank : 22)
Query Neighborhood Hits	93	Target Neighborhood Hits	592	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_HUMAN
NC score	0.102741 (rank : 25)	θ value	0.000602161 (rank : 20)
Query Neighborhood Hits	93	Target Neighborhood Hits	599	Shared Neighborhood Hits	30
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
NC score	0.102201 (rank : 26)	θ value	0.00175202 (rank : 23)
Query Neighborhood Hits	93	Target Neighborhood Hits	625	Shared Neighborhood Hits	32
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

CYH4_MOUSE
NC score	0.097130 (rank : 27)	θ value	1.81305 (rank : 55)
Query Neighborhood Hits	93	Target Neighborhood Hits	134	Shared Neighborhood Hits	38
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

CYH4_HUMAN
NC score	0.095139 (rank : 28)	θ value	3.0926 (rank : 62)
Query Neighborhood Hits	93	Target Neighborhood Hits	135	Shared Neighborhood Hits	38
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

DDFL1_HUMAN
NC score	0.090027 (rank : 29)	θ value	0.0736092 (rank : 29)
Query Neighborhood Hits	93	Target Neighborhood Hits	353	Shared Neighborhood Hits	25
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

CYH3_MOUSE
NC score	0.088847 (rank : 30)	θ value	0.21417 (rank : 37)
Query Neighborhood Hits	93	Target Neighborhood Hits	148	Shared Neighborhood Hits	38
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

DDFL1_MOUSE
NC score	0.088523 (rank : 31)	θ value	0.163984 (rank : 35)
Query Neighborhood Hits	93	Target Neighborhood Hits	324	Shared Neighborhood Hits	22
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

CYH3_HUMAN
NC score	0.083663 (rank : 32)	θ value	0.0148317 (rank : 25)
Query Neighborhood Hits	93	Target Neighborhood Hits	137	Shared Neighborhood Hits	32
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

CYH2_HUMAN
NC score	0.083231 (rank : 33)	θ value	0.0961366 (rank : 31)
Query Neighborhood Hits	93	Target Neighborhood Hits	175	Shared Neighborhood Hits	37
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
NC score	0.083183 (rank : 34)	θ value	0.0961366 (rank : 32)
Query Neighborhood Hits	93	Target Neighborhood Hits	171	Shared Neighborhood Hits	37
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH1_HUMAN
NC score	0.082213 (rank : 35)	θ value	0.279714 (rank : 39)
Query Neighborhood Hits	93	Target Neighborhood Hits	184	Shared Neighborhood Hits	38
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
NC score	0.080871 (rank : 36)	θ value	0.365318 (rank : 40)
Query Neighborhood Hits	93	Target Neighborhood Hits	176	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

MTMRD_HUMAN
NC score	0.078981 (rank : 37)	θ value	0.125558 (rank : 33)
Query Neighborhood Hits	93	Target Neighborhood Hits	135	Shared Neighborhood Hits	40
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

PKHA2_MOUSE
NC score	0.077238 (rank : 38)	θ value	6.88961 (rank : 80)
Query Neighborhood Hits	93	Target Neighborhood Hits	116	Shared Neighborhood Hits	34
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

SWP70_HUMAN
NC score	0.072960 (rank : 39)	θ value	8.99809 (rank : 93)
Query Neighborhood Hits	93	Target Neighborhood Hits	973	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

PKHA1_HUMAN
NC score	0.072017 (rank : 40)	θ value	0.813845 (rank : 45)
Query Neighborhood Hits	93	Target Neighborhood Hits	127	Shared Neighborhood Hits	37
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA2_HUMAN
NC score	0.071798 (rank : 41)	θ value	1.81305 (rank : 57)
Query Neighborhood Hits	93	Target Neighborhood Hits	119	Shared Neighborhood Hits	34
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

SWP70_MOUSE
NC score	0.069880 (rank : 42)	θ value	6.88961 (rank : 85)
Query Neighborhood Hits	93	Target Neighborhood Hits	1097	Shared Neighborhood Hits	60
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

PKHA6_HUMAN
NC score	0.068576 (rank : 43)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	93	Target Neighborhood Hits	556	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

GAB2_MOUSE
NC score	0.066296 (rank : 44)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	93	Target Neighborhood Hits	220	Shared Neighborhood Hits	29
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

GAB2_HUMAN
NC score	0.066043 (rank : 45)	θ value	1.06291 (rank : 47)
Query Neighborhood Hits	93	Target Neighborhood Hits	188	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

PLEK2_MOUSE
NC score	0.065541 (rank : 46)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	93	Target Neighborhood Hits	96	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

CENB5_HUMAN
NC score	0.064954 (rank : 47)	θ value	1.81305 (rank : 54)
Query Neighborhood Hits	93	Target Neighborhood Hits	395	Shared Neighborhood Hits	43
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

PLEK2_HUMAN
NC score	0.064262 (rank : 48)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	93	Target Neighborhood Hits	101	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

TBCD2_HUMAN
NC score	0.063990 (rank : 49)	θ value	0.62314 (rank : 43)
Query Neighborhood Hits	93	Target Neighborhood Hits	419	Shared Neighborhood Hits	35
SwissProt Accessions	Q9BYX2	Gene names	TBC1D2, PARIS1
Domain Architecture
Description	TBC1 domain family member 2 (Prostate antigen recognized and identified by SEREX) (PARIS-1).

FBX28_HUMAN
NC score	0.063869 (rank : 50)	θ value	0.0193708 (rank : 26)
Query Neighborhood Hits	93	Target Neighborhood Hits	110	Shared Neighborhood Hits	6
SwissProt Accessions	Q9NVF7, O75070	Gene names	FBXO28, KIAA0483
Domain Architecture	No domain graphic available
Description	F-box only protein 28.

RHG25_MOUSE
NC score	0.063538 (rank : 51)	θ value	1.81305 (rank : 59)
Query Neighborhood Hits	93	Target Neighborhood Hits	492	Shared Neighborhood Hits	40
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG25_HUMAN
NC score	0.063137 (rank : 52)	θ value	1.81305 (rank : 58)
Query Neighborhood Hits	93	Target Neighborhood Hits	550	Shared Neighborhood Hits	49
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

PKHA1_MOUSE
NC score	0.062730 (rank : 53)	θ value	3.0926 (rank : 65)
Query Neighborhood Hits	93	Target Neighborhood Hits	120	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA6_MOUSE
NC score	0.062194 (rank : 54)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	93	Target Neighborhood Hits	591	Shared Neighborhood Hits	45
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

CENB1_HUMAN
NC score	0.062043 (rank : 55)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	93	Target Neighborhood Hits	383	Shared Neighborhood Hits	41
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

TARA_MOUSE
NC score	0.057829 (rank : 56)	θ value	1.06291 (rank : 51)
Query Neighborhood Hits	93	Target Neighborhood Hits	1133	Shared Neighborhood Hits	48
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

PLEK_MOUSE
NC score	0.054484 (rank : 57)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	93	Target Neighborhood Hits	109	Shared Neighborhood Hits	32
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

MYO10_HUMAN
NC score	0.053310 (rank : 58)	θ value	0.0736092 (rank : 30)
Query Neighborhood Hits	93	Target Neighborhood Hits	920	Shared Neighborhood Hits	55
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

DAPP1_MOUSE
NC score	0.052672 (rank : 59)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	93	Target Neighborhood Hits	225	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

PLEK_HUMAN
NC score	0.052533 (rank : 60)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	93	Target Neighborhood Hits	110	Shared Neighborhood Hits	33
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PKHA4_HUMAN
NC score	0.050587 (rank : 61)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	93	Target Neighborhood Hits	283	Shared Neighborhood Hits	31
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

GAB1_HUMAN
NC score	0.049647 (rank : 62)	θ value	1.38821 (rank : 53)
Query Neighborhood Hits	93	Target Neighborhood Hits	279	Shared Neighborhood Hits	27
SwissProt Accessions	Q13480, Q4W5G2, Q6P1W2	Gene names	GAB1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

GAB1_MOUSE
NC score	0.048246 (rank : 63)	θ value	1.81305 (rank : 56)
Query Neighborhood Hits	93	Target Neighborhood Hits	233	Shared Neighborhood Hits	24
SwissProt Accessions	Q9QYY0, Q91VW7	Gene names	Gab1
Domain Architecture
Description	GRB2-associated-binding protein 1 (GRB2-associated binder 1).

DGKH_HUMAN
NC score	0.038679 (rank : 64)	θ value	0.0563607 (rank : 27)
Query Neighborhood Hits	93	Target Neighborhood Hits	255	Shared Neighborhood Hits	26
SwissProt Accessions	Q86XP1, Q5VZW0, Q6PI56, Q86XP2, Q8N3N0, Q8N7J9	Gene names	DGKH
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase eta (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) (DAG kinase eta).

MYPT2_HUMAN
NC score	0.036407 (rank : 65)	θ value	8.99809 (rank : 89)
Query Neighborhood Hits	93	Target Neighborhood Hits	707	Shared Neighborhood Hits	25
SwissProt Accessions	O60237, Q8N179, Q9HCB7, Q9HCB8	Gene names	PPP1R12B, MYPT2
Domain Architecture
Description	Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase- targeting subunit 2) (Myosin phosphatase target subunit 2).

TARA_HUMAN
NC score	0.035579 (rank : 66)	θ value	1.06291 (rank : 50)
Query Neighborhood Hits	93	Target Neighborhood Hits	1626	Shared Neighborhood Hits	47
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

SPAT7_HUMAN
NC score	0.032721 (rank : 67)	θ value	3.0926 (rank : 67)
Query Neighborhood Hits	93	Target Neighborhood Hits	50	Shared Neighborhood Hits	3
SwissProt Accessions	Q9P0W8, Q8WX30, Q96HF3, Q9H0X0, Q9P0W7	Gene names	SPATA7, HSD3
Domain Architecture	No domain graphic available
Description	Spermatogenesis-associated protein 7 (Spermatogenesis-associated protein HSD3) (HSD-3.1).

IP3KC_MOUSE
NC score	0.030887 (rank : 68)	θ value	1.06291 (rank : 48)
Query Neighborhood Hits	93	Target Neighborhood Hits	40	Shared Neighborhood Hits	3
SwissProt Accessions	Q7TS72, Q3U384	Gene names	Itpkc
Domain Architecture	No domain graphic available
Description	Inositol-trisphosphate 3-kinase C (EC 2.7.1.127) (Inositol 1,4,5- trisphosphate 3-kinase C) (IP3K-C).

MYRIP_MOUSE
NC score	0.029982 (rank : 69)	θ value	0.0563607 (rank : 28)
Query Neighborhood Hits	93	Target Neighborhood Hits	207	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K3I4, Q8CFC0, Q8K4H5	Gene names	Myrip, Slac2c
Domain Architecture
Description	Rab effector MyRIP (Myosin-VIIa- and Rab-interacting protein) (Exophilin-8) (Slp homolog lacking C2 domains c).

FARP1_HUMAN
NC score	0.028442 (rank : 70)	θ value	2.36792 (rank : 61)
Query Neighborhood Hits	93	Target Neighborhood Hits	241	Shared Neighborhood Hits	35
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

RAI14_HUMAN
NC score	0.024638 (rank : 71)	θ value	3.0926 (rank : 66)
Query Neighborhood Hits	93	Target Neighborhood Hits	1367	Shared Neighborhood Hits	30
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

EMSY_HUMAN
NC score	0.020843 (rank : 72)	θ value	1.06291 (rank : 46)
Query Neighborhood Hits	93	Target Neighborhood Hits	296	Shared Neighborhood Hits	4
SwissProt Accessions	Q7Z589, Q4G109, Q8NBU6, Q8TE50, Q9H8I9, Q9NRH0	Gene names	EMSY, C11orf30
Domain Architecture
Description	Protein EMSY.

STX12_MOUSE
NC score	0.018369 (rank : 73)	θ value	1.06291 (rank : 49)
Query Neighborhood Hits	93	Target Neighborhood Hits	283	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ER00, Q3UIV9, Q921T9	Gene names	Stx12
Domain Architecture
Description	Syntaxin-12.

ANR26_HUMAN
NC score	0.017490 (rank : 74)	θ value	4.03905 (rank : 68)
Query Neighborhood Hits	93	Target Neighborhood Hits	1614	Shared Neighborhood Hits	34
SwissProt Accessions	Q9UPS8, Q2TAZ3, Q6ZR14, Q9H1Q1, Q9NSK9, Q9NTD5, Q9NW69	Gene names	ANKRD26, KIAA1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

EMSY_MOUSE
NC score	0.016781 (rank : 75)	θ value	5.27518 (rank : 75)
Query Neighborhood Hits	93	Target Neighborhood Hits	294	Shared Neighborhood Hits	5
SwissProt Accessions	Q8BMB0, Q5FWK5, Q80XU1, Q8VDW9	Gene names	Emsy
Domain Architecture
Description	Protein EMSY.

STX12_HUMAN
NC score	0.015276 (rank : 76)	θ value	4.03905 (rank : 73)
Query Neighborhood Hits	93	Target Neighborhood Hits	226	Shared Neighborhood Hits	11
SwissProt Accessions	Q86Y82, O95564	Gene names	STX12
Domain Architecture
Description	Syntaxin-12.

NSD1_MOUSE
NC score	0.013654 (rank : 77)	θ value	0.813845 (rank : 44)
Query Neighborhood Hits	93	Target Neighborhood Hits	472	Shared Neighborhood Hits	9
SwissProt Accessions	O88491, Q8C480, Q9CT70	Gene names	Nsd1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (EC 2.1.1.43) (H3-K36-HMTase) (H4-K20-HMTase) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein).

GOGB1_HUMAN
NC score	0.013569 (rank : 78)	θ value	6.88961 (rank : 78)
Query Neighborhood Hits	93	Target Neighborhood Hits	2297	Shared Neighborhood Hits	41
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

RRBP1_HUMAN
NC score	0.013430 (rank : 79)	θ value	0.21417 (rank : 38)
Query Neighborhood Hits	93	Target Neighborhood Hits	1306	Shared Neighborhood Hits	22
SwissProt Accessions	Q9P2E9, O75300, O75301, Q5W165, Q96SB2, Q9BWP1, Q9H476	Gene names	RRBP1, KIAA1398
Domain Architecture
Description	Ribosome-binding protein 1 (Ribosome receptor protein) (180 kDa ribosome receptor homolog) (ES/130-related protein).

CLMN_HUMAN
NC score	0.013424 (rank : 80)	θ value	0.62314 (rank : 42)
Query Neighborhood Hits	93	Target Neighborhood Hits	205	Shared Neighborhood Hits	6
SwissProt Accessions	Q96JQ2, Q9H713, Q9HA23, Q9HA57, Q9UFP4, Q9ULN2	Gene names	CLMN, KIAA1188
Domain Architecture
Description	Calmin.

CREB3_MOUSE
NC score	0.011520 (rank : 81)	θ value	5.27518 (rank : 74)
Query Neighborhood Hits	93	Target Neighborhood Hits	97	Shared Neighborhood Hits	6
SwissProt Accessions	Q61817, Q99M21, Q9CVK9	Gene names	Creb3, Lzip
Domain Architecture	No domain graphic available
Description	Cyclic AMP-responsive element-binding protein 3 (Transcription factor LZIP).

GCC2_MOUSE
NC score	0.011150 (rank : 82)	θ value	5.27518 (rank : 76)
Query Neighborhood Hits	93	Target Neighborhood Hits	1619	Shared Neighborhood Hits	36
SwissProt Accessions	Q8CHG3, Q8BR44, Q8R2Q5, Q9CT45	Gene names	Gcc2, Kiaa0336
Domain Architecture
Description	GRIP and coiled-coil domain-containing protein 2 (Golgi coiled coil protein GCC185).

IDD_HUMAN
NC score	0.010940 (rank : 83)	θ value	3.0926 (rank : 64)
Query Neighborhood Hits	93	Target Neighborhood Hits	127	Shared Neighborhood Hits	2
SwissProt Accessions	P98153	Gene names	DGCR2, IDD, KIAA0163
Domain Architecture
Description	Integral membrane protein DGCR2/IDD precursor.

FLIP1_MOUSE
NC score	0.010672 (rank : 84)	θ value	1.38821 (rank : 52)
Query Neighborhood Hits	93	Target Neighborhood Hits	1176	Shared Neighborhood Hits	24
SwissProt Accessions	Q9CS72	Gene names	Filip1
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

SPTA2_HUMAN
NC score	0.009414 (rank : 85)	θ value	1.81305 (rank : 60)
Query Neighborhood Hits	93	Target Neighborhood Hits	888	Shared Neighborhood Hits	20
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

NPHP3_MOUSE
NC score	0.009341 (rank : 86)	θ value	4.03905 (rank : 70)
Query Neighborhood Hits	93	Target Neighborhood Hits	335	Shared Neighborhood Hits	12
SwissProt Accessions	Q7TNH6, Q69Z39, Q8C798, Q8C7Z3, Q9D6D1	Gene names	Nphp3, Kiaa2000
Domain Architecture	No domain graphic available
Description	Nephrocystin-3.

PLEC1_HUMAN
NC score	0.009045 (rank : 87)	θ value	0.47712 (rank : 41)
Query Neighborhood Hits	93	Target Neighborhood Hits	1326	Shared Neighborhood Hits	27
SwissProt Accessions	Q15149, Q15148, Q16640	Gene names	PLEC1
Domain Architecture
Description	Plectin-1 (PLTN) (PCN) (Hemidesmosomal protein 1) (HD1).

FLIP1_HUMAN
NC score	0.008578 (rank : 88)	θ value	3.0926 (rank : 63)
Query Neighborhood Hits	93	Target Neighborhood Hits	1405	Shared Neighborhood Hits	27
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

SLAF6_MOUSE
NC score	0.008472 (rank : 89)	θ value	6.88961 (rank : 84)
Query Neighborhood Hits	93	Target Neighborhood Hits	42	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ET39, Q9ET40	Gene names	Slamf6, Ly108
Domain Architecture	No domain graphic available
Description	SLAM family member 6 precursor (Lymphocyte antigen 108).

PRDM2_HUMAN
NC score	0.008107 (rank : 90)	θ value	4.03905 (rank : 71)
Query Neighborhood Hits	93	Target Neighborhood Hits	1135	Shared Neighborhood Hits	10
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

ST18_MOUSE
NC score	0.007811 (rank : 91)	θ value	4.03905 (rank : 72)
Query Neighborhood Hits	93	Target Neighborhood Hits	248	Shared Neighborhood Hits	10
SwissProt Accessions	Q80TY4, Q3UH00, Q3URH9, Q3UVB9, Q3UZN9, Q811B4, Q8K098	Gene names	St18, Kiaa0535
Domain Architecture	No domain graphic available
Description	Suppression of tumorigenicity protein 18.

SIA7C_HUMAN
NC score	0.007001 (rank : 92)	θ value	5.27518 (rank : 77)
Query Neighborhood Hits	93	Target Neighborhood Hits	38	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NDV1, Q6UX29, Q8N259	Gene names	ST6GALNAC3, SIAT7C
Domain Architecture
Description	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 (EC 2.4.99.-) (GalNAc alpha-2,6-sialyltransferase III) (ST6GalNAc III) (Sialyltransferase 7C) (STY).

LEO1_HUMAN
NC score	0.006591 (rank : 93)	θ value	4.03905 (rank : 69)
Query Neighborhood Hits	93	Target Neighborhood Hits	958	Shared Neighborhood Hits	12
SwissProt Accessions	Q8WVC0, Q96N99	Gene names	LEO1, RDL
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1 (Replicative senescence down- regulated leo1-like protein).

NOP56_HUMAN
NC score	0.006168 (rank : 94)	θ value	8.99809 (rank : 90)
Query Neighborhood Hits	93	Target Neighborhood Hits	95	Shared Neighborhood Hits	3
SwissProt Accessions	O00567, Q9NQ05	Gene names	NOL5A, NOP56
Domain Architecture
Description	Nucleolar protein Nop56 (Nucleolar protein 5A).

ARTS1_HUMAN
NC score	0.004893 (rank : 95)	θ value	8.99809 (rank : 86)
Query Neighborhood Hits	93	Target Neighborhood Hits	27	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZ08, O60278, Q6UWY6, Q8NEL4, Q8TAD0, Q9UHF8, Q9UKY2	Gene names	ARTS1, APPILS, KIAA0525
Domain Architecture
Description	Adipocyte-derived leucine aminopeptidase precursor (EC 3.4.11.-) (A- LAP) (ARTS-1) (Aminopeptidase PILS) (Puromycin-insensitive leucyl- specific aminopeptidase) (PILS-AP) (Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator).

PER2_HUMAN
NC score	0.004073 (rank : 96)	θ value	8.99809 (rank : 91)
Query Neighborhood Hits	93	Target Neighborhood Hits	170	Shared Neighborhood Hits	4
SwissProt Accessions	O15055	Gene names	PER2, KIAA0347
Domain Architecture
Description	Period circadian protein 2.

RGS3_MOUSE
NC score	0.003988 (rank : 97)	θ value	6.88961 (rank : 82)
Query Neighborhood Hits	93	Target Neighborhood Hits	1621	Shared Neighborhood Hits	12
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

SEM4B_MOUSE
NC score	0.003335 (rank : 98)	θ value	6.88961 (rank : 83)
Query Neighborhood Hits	93	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	Q62179, Q4PKI6, Q69ZB7	Gene names	Sema4b, Kiaa1745, Semac, SemC
Domain Architecture	No domain graphic available
Description	Semaphorin-4B precursor (Semaphorin C) (Sema C).

SEM4B_HUMAN
NC score	0.003024 (rank : 99)	θ value	8.99809 (rank : 92)
Query Neighborhood Hits	93	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NPR2, Q6UXE3, Q8WVP9, Q96FK5, Q9C0B8, Q9H691, Q9NPM8, Q9NPN0	Gene names	SEMA4B, KIAA1745
Domain Architecture
Description	Semaphorin-4B precursor.

RGS3_HUMAN
NC score	0.002882 (rank : 100)	θ value	6.88961 (rank : 81)
Query Neighborhood Hits	93	Target Neighborhood Hits	1375	Shared Neighborhood Hits	13
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

K2C5_HUMAN
NC score	0.002674 (rank : 101)	θ value	6.88961 (rank : 79)
Query Neighborhood Hits	93	Target Neighborhood Hits	506	Shared Neighborhood Hits	13
SwissProt Accessions	P13647, Q6PI71, Q6UBJ0, Q8TA91	Gene names	KRT5
Domain Architecture
Description	Keratin, type II cytoskeletal 5 (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (58 kDa cytokeratin).

K2C6E_HUMAN
NC score	0.002488 (rank : 102)	θ value	8.99809 (rank : 88)
Query Neighborhood Hits	93	Target Neighborhood Hits	516	Shared Neighborhood Hits	17
SwissProt Accessions	P48668, Q7RTN9	Gene names	KRT6E
Domain Architecture
Description	Keratin, type II cytoskeletal 6E (Cytokeratin-6E) (CK 6E) (K6e keratin) (Keratin K6h).

K2C6B_HUMAN
NC score	0.002432 (rank : 103)	θ value	8.99809 (rank : 87)
Query Neighborhood Hits	93	Target Neighborhood Hits	526	Shared Neighborhood Hits	18
SwissProt Accessions	P04259, P48669	Gene names	KRT6B, K6B
Domain Architecture
Description	Keratin, type II cytoskeletal 6B (Cytokeratin-6B) (CK 6B) (K6b keratin).