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Network neighborhood for query Sequence : PKHA3_HUMAN

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PKHA3_HUMAN
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PKHA3_HUMAN
θ value	4.4118e-156 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	66	Target Neighborhood Hits	66	Shared Neighborhood Hits	66
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PKHA3_MOUSE
θ value	3.06949e-141 (rank : 2)	NC score	0.994189 (rank : 2)
Query Neighborhood Hits	66	Target Neighborhood Hits	67	Shared Neighborhood Hits	58
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

OSBP1_HUMAN
θ value	2.97466e-19 (rank : 3)	NC score	0.564165 (rank : 6)
Query Neighborhood Hits	66	Target Neighborhood Hits	180	Shared Neighborhood Hits	52
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

OSBL9_HUMAN
θ value	1.38178e-16 (rank : 4)	NC score	0.569052 (rank : 5)
Query Neighborhood Hits	66	Target Neighborhood Hits	138	Shared Neighborhood Hits	42
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

C43BP_HUMAN
θ value	1.80466e-16 (rank : 5)	NC score	0.670563 (rank : 3)
Query Neighborhood Hits	66	Target Neighborhood Hits	87	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

C43BP_MOUSE
θ value	1.80466e-16 (rank : 6)	NC score	0.667545 (rank : 4)
Query Neighborhood Hits	66	Target Neighborhood Hits	91	Shared Neighborhood Hits	49
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

OSBP2_HUMAN
θ value	2.20605e-14 (rank : 7)	NC score	0.543696 (rank : 7)
Query Neighborhood Hits	66	Target Neighborhood Hits	154	Shared Neighborhood Hits	50
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

OSBP2_MOUSE
θ value	1.2105e-12 (rank : 8)	NC score	0.519765 (rank : 8)
Query Neighborhood Hits	66	Target Neighborhood Hits	150	Shared Neighborhood Hits	43
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

OSB11_MOUSE
θ value	8.97725e-08 (rank : 9)	NC score	0.495263 (rank : 9)
Query Neighborhood Hits	66	Target Neighborhood Hits	71	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CI95	Gene names	Osbpl11
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

OSB11_HUMAN
θ value	1.99992e-07 (rank : 10)	NC score	0.488577 (rank : 10)
Query Neighborhood Hits	66	Target Neighborhood Hits	60	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BXB4	Gene names	OSBPL11, ORP11, OSBP12
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

OSB10_HUMAN
θ value	1.29631e-06 (rank : 11)	NC score	0.467698 (rank : 11)
Query Neighborhood Hits	66	Target Neighborhood Hits	55	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BXB5, Q9BTU5	Gene names	OSBPL10, ORP10, OSBP9
Domain Architecture
Description	Oxysterol-binding protein-related protein 10 (OSBP-related protein 10) (ORP-10).

MTMRD_HUMAN
θ value	5.44631e-05 (rank : 12)	NC score	0.211070 (rank : 28)
Query Neighborhood Hits	66	Target Neighborhood Hits	135	Shared Neighborhood Hits	41
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

FGD6_MOUSE
θ value	0.00134147 (rank : 13)	NC score	0.114734 (rank : 37)
Query Neighborhood Hits	66	Target Neighborhood Hits	282	Shared Neighborhood Hits	28
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FGD6_HUMAN
θ value	0.00298849 (rank : 14)	NC score	0.110838 (rank : 39)
Query Neighborhood Hits	66	Target Neighborhood Hits	237	Shared Neighborhood Hits	33
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

OSBL6_HUMAN
θ value	0.00665767 (rank : 15)	NC score	0.351684 (rank : 13)
Query Neighborhood Hits	66	Target Neighborhood Hits	101	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BZF3, Q7Z4Q1, Q96SR1	Gene names	OSBPL6, ORP6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

OSBL6_MOUSE
θ value	0.00665767 (rank : 16)	NC score	0.347939 (rank : 14)
Query Neighborhood Hits	66	Target Neighborhood Hits	105	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BXR9, Q8BYW2	Gene names	Osbpl6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

OSBL7_HUMAN
θ value	0.00665767 (rank : 17)	NC score	0.364992 (rank : 12)
Query Neighborhood Hits	66	Target Neighborhood Hits	71	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BZF2	Gene names	OSBPL7, ORP7
Domain Architecture
Description	Oxysterol-binding protein-related protein 7 (OSBP-related protein 7) (ORP-7).

SWP70_HUMAN
θ value	0.00869519 (rank : 18)	NC score	0.166522 (rank : 31)
Query Neighborhood Hits	66	Target Neighborhood Hits	973	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
θ value	0.00869519 (rank : 19)	NC score	0.160320 (rank : 32)
Query Neighborhood Hits	66	Target Neighborhood Hits	1097	Shared Neighborhood Hits	52
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

OSBL1_MOUSE
θ value	0.0193708 (rank : 20)	NC score	0.265860 (rank : 22)
Query Neighborhood Hits	66	Target Neighborhood Hits	336	Shared Neighborhood Hits	23
SwissProt Accessions	Q91XL9, O88318, Q3TH97, Q673L8, Q6DFU6	Gene names	Osbpl1a, Orp1, Orp1a
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

MTMR5_HUMAN
θ value	0.0431538 (rank : 21)	NC score	0.158059 (rank : 33)
Query Neighborhood Hits	66	Target Neighborhood Hits	141	Shared Neighborhood Hits	35
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

PLEK_HUMAN
θ value	0.0431538 (rank : 22)	NC score	0.215318 (rank : 27)
Query Neighborhood Hits	66	Target Neighborhood Hits	110	Shared Neighborhood Hits	40
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

PLEK_MOUSE
θ value	0.0431538 (rank : 23)	NC score	0.221913 (rank : 24)
Query Neighborhood Hits	66	Target Neighborhood Hits	109	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

CEND1_HUMAN
θ value	0.0563607 (rank : 24)	NC score	0.109331 (rank : 41)
Query Neighborhood Hits	66	Target Neighborhood Hits	284	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CEND2_HUMAN
θ value	0.0961366 (rank : 25)	NC score	0.102999 (rank : 47)
Query Neighborhood Hits	66	Target Neighborhood Hits	166	Shared Neighborhood Hits	28
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

OSBL1_HUMAN
θ value	0.0961366 (rank : 26)	NC score	0.251980 (rank : 23)
Query Neighborhood Hits	66	Target Neighborhood Hits	368	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BXW6, Q9BZF5, Q9NW87	Gene names	OSBPL1A, ORP1, OSBP8, OSBPL1
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

OSBL3_HUMAN
θ value	0.125558 (rank : 27)	NC score	0.347549 (rank : 15)
Query Neighborhood Hits	66	Target Neighborhood Hits	93	Shared Neighborhood Hits	32
SwissProt Accessions	Q9H4L5, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9UED6	Gene names	OSBPL3, KIAA0704, ORP3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

CEND1_MOUSE
θ value	0.163984 (rank : 28)	NC score	0.092790 (rank : 54)
Query Neighborhood Hits	66	Target Neighborhood Hits	260	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

PKHA5_HUMAN
θ value	0.163984 (rank : 29)	NC score	0.140117 (rank : 34)
Query Neighborhood Hits	66	Target Neighborhood Hits	455	Shared Neighborhood Hits	41
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

URP2_HUMAN
θ value	0.21417 (rank : 30)	NC score	0.100467 (rank : 49)
Query Neighborhood Hits	66	Target Neighborhood Hits	30	Shared Neighborhood Hits	12
SwissProt Accessions	Q86UX7, Q8IUA1, Q8N207, Q9BT48	Gene names	URP2, KIND3, MIG2B
Domain Architecture
Description	Unc-112-related protein 2 (Kindlin-3) (MIG2-like).

URP2_MOUSE
θ value	0.21417 (rank : 31)	NC score	0.111844 (rank : 38)
Query Neighborhood Hits	66	Target Neighborhood Hits	37	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K1B8	Gene names	Urp2, Kind3
Domain Architecture
Description	Unc-112-related protein 2 (Kindlin-3).

PKHA6_MOUSE
θ value	0.365318 (rank : 32)	NC score	0.184231 (rank : 30)
Query Neighborhood Hits	66	Target Neighborhood Hits	591	Shared Neighborhood Hits	44
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

OSBL3_MOUSE
θ value	0.47712 (rank : 33)	NC score	0.347492 (rank : 16)
Query Neighborhood Hits	66	Target Neighborhood Hits	86	Shared Neighborhood Hits	32
SwissProt Accessions	Q9DBS9	Gene names	Osbpl3, Orp3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

PLEK2_HUMAN
θ value	0.47712 (rank : 34)	NC score	0.218846 (rank : 26)
Query Neighborhood Hits	66	Target Neighborhood Hits	101	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_MOUSE
θ value	0.47712 (rank : 35)	NC score	0.220516 (rank : 25)
Query Neighborhood Hits	66	Target Neighborhood Hits	96	Shared Neighborhood Hits	43
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

BMX_HUMAN
θ value	0.62314 (rank : 36)	NC score	0.018713 (rank : 79)
Query Neighborhood Hits	66	Target Neighborhood Hits	942	Shared Neighborhood Hits	29
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

LAMA1_MOUSE
θ value	0.62314 (rank : 37)	NC score	0.009872 (rank : 89)
Query Neighborhood Hits	66	Target Neighborhood Hits	838	Shared Neighborhood Hits	3
SwissProt Accessions	P19137	Gene names	Lama1, Lama, Lama-1
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

PKHA6_HUMAN
θ value	0.62314 (rank : 38)	NC score	0.189480 (rank : 29)
Query Neighborhood Hits	66	Target Neighborhood Hits	556	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

CNKR2_HUMAN
θ value	0.813845 (rank : 39)	NC score	0.107963 (rank : 43)
Query Neighborhood Hits	66	Target Neighborhood Hits	197	Shared Neighborhood Hits	32
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	0.813845 (rank : 40)	NC score	0.108039 (rank : 42)
Query Neighborhood Hits	66	Target Neighborhood Hits	197	Shared Neighborhood Hits	32
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CYH4_MOUSE
θ value	0.813845 (rank : 41)	NC score	0.126830 (rank : 35)
Query Neighborhood Hits	66	Target Neighborhood Hits	134	Shared Neighborhood Hits	45
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

BMX_MOUSE
θ value	1.06291 (rank : 42)	NC score	0.017168 (rank : 81)
Query Neighborhood Hits	66	Target Neighborhood Hits	912	Shared Neighborhood Hits	28
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

AKT1_HUMAN
θ value	1.38821 (rank : 43)	NC score	0.012792 (rank : 84)
Query Neighborhood Hits	66	Target Neighborhood Hits	885	Shared Neighborhood Hits	30
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

MYO10_HUMAN
θ value	1.38821 (rank : 44)	NC score	0.063277 (rank : 69)
Query Neighborhood Hits	66	Target Neighborhood Hits	920	Shared Neighborhood Hits	51
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

AKT1_MOUSE
θ value	2.36792 (rank : 45)	NC score	0.012616 (rank : 85)
Query Neighborhood Hits	66	Target Neighborhood Hits	878	Shared Neighborhood Hits	29
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

CYH4_HUMAN
θ value	2.36792 (rank : 46)	NC score	0.120341 (rank : 36)
Query Neighborhood Hits	66	Target Neighborhood Hits	135	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

HPS5_HUMAN
θ value	2.36792 (rank : 47)	NC score	0.025871 (rank : 78)
Query Neighborhood Hits	66	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UPZ3, O95942, Q8N4U0	Gene names	HPS5, AIBP63, KIAA1017
Domain Architecture	No domain graphic available
Description	Hermansky-Pudlak syndrome 5 protein (Alpha-integrin-binding protein 63) (Ruby-eye protein 2 homolog) (Ru2).

ITK_HUMAN
θ value	3.0926 (rank : 48)	NC score	0.010927 (rank : 88)
Query Neighborhood Hits	66	Target Neighborhood Hits	1016	Shared Neighborhood Hits	22
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

MRIP_MOUSE
θ value	3.0926 (rank : 49)	NC score	0.088057 (rank : 56)
Query Neighborhood Hits	66	Target Neighborhood Hits	569	Shared Neighborhood Hits	36
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

TARA_HUMAN
θ value	3.0926 (rank : 50)	NC score	0.055187 (rank : 75)
Query Neighborhood Hits	66	Target Neighborhood Hits	1626	Shared Neighborhood Hits	38
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

CYH2_HUMAN
θ value	4.03905 (rank : 51)	NC score	0.086248 (rank : 58)
Query Neighborhood Hits	66	Target Neighborhood Hits	175	Shared Neighborhood Hits	43
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH2_MOUSE
θ value	4.03905 (rank : 52)	NC score	0.086258 (rank : 57)
Query Neighborhood Hits	66	Target Neighborhood Hits	171	Shared Neighborhood Hits	43
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH3_MOUSE
θ value	4.03905 (rank : 53)	NC score	0.105013 (rank : 46)
Query Neighborhood Hits	66	Target Neighborhood Hits	148	Shared Neighborhood Hits	47
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

MRIP_HUMAN
θ value	4.03905 (rank : 54)	NC score	0.082468 (rank : 60)
Query Neighborhood Hits	66	Target Neighborhood Hits	578	Shared Neighborhood Hits	38
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

OXR1_MOUSE
θ value	4.03905 (rank : 55)	NC score	0.018339 (rank : 80)
Query Neighborhood Hits	66	Target Neighborhood Hits	516	Shared Neighborhood Hits	4
SwissProt Accessions	Q4KMM3, Q5FWW1, Q99L06, Q99MK1, Q99MP4	Gene names	Oxr1, C7
Domain Architecture	No domain graphic available
Description	Oxidation resistance protein 1 (Protein C7).

TARA_MOUSE
θ value	4.03905 (rank : 56)	NC score	0.076132 (rank : 64)
Query Neighborhood Hits	66	Target Neighborhood Hits	1133	Shared Neighborhood Hits	36
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

RHG25_HUMAN
θ value	5.27518 (rank : 57)	NC score	0.101485 (rank : 48)
Query Neighborhood Hits	66	Target Neighborhood Hits	550	Shared Neighborhood Hits	47
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

SEPT9_HUMAN
θ value	5.27518 (rank : 58)	NC score	0.005754 (rank : 90)
Query Neighborhood Hits	66	Target Neighborhood Hits	706	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).

ZP2_MOUSE
θ value	5.27518 (rank : 59)	NC score	0.015100 (rank : 82)
Query Neighborhood Hits	66	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	P20239	Gene names	Zp2, Zp-2, Zpa
Domain Architecture
Description	Zona pellucida sperm-binding protein 2 precursor (Zona pellucida glycoprotein ZP2) (Zona pellucida protein A).

ALMS1_MOUSE
θ value	6.88961 (rank : 60)	NC score	0.014156 (rank : 83)
Query Neighborhood Hits	66	Target Neighborhood Hits	181	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K4E0, Q6A084, Q8C9N9	Gene names	Alms1, Kiaa0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1 homolog.

CYH1_HUMAN
θ value	6.88961 (rank : 61)	NC score	0.085928 (rank : 59)
Query Neighborhood Hits	66	Target Neighborhood Hits	184	Shared Neighborhood Hits	46
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

CYH1_MOUSE
θ value	6.88961 (rank : 62)	NC score	0.082145 (rank : 61)
Query Neighborhood Hits	66	Target Neighborhood Hits	176	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

GAB2_MOUSE
θ value	6.88961 (rank : 63)	NC score	0.088908 (rank : 55)
Query Neighborhood Hits	66	Target Neighborhood Hits	220	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

GNRP_HUMAN
θ value	8.99809 (rank : 64)	NC score	0.069252 (rank : 67)
Query Neighborhood Hits	66	Target Neighborhood Hits	239	Shared Neighborhood Hits	33
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

NFIX_HUMAN
θ value	8.99809 (rank : 65)	NC score	0.012104 (rank : 87)
Query Neighborhood Hits	66	Target Neighborhood Hits	38	Shared Neighborhood Hits	4
SwissProt Accessions	Q14938, O60413, Q12859, Q13050, Q13052, Q9UPH1, Q9Y6R8	Gene names	NFIX
Domain Architecture
Description	Nuclear factor 1 X-type (Nuclear factor 1/X) (NF1-X) (NFI-X) (NF-I/X) (CCAAT-box-binding transcription factor) (CTF) (TGGCA-binding protein).

NFIX_MOUSE
θ value	8.99809 (rank : 66)	NC score	0.012206 (rank : 86)
Query Neighborhood Hits	66	Target Neighborhood Hits	35	Shared Neighborhood Hits	4
SwissProt Accessions	P70257, O08519, P70258, Q64192, Q99L78, Q9R1G2	Gene names	Nfix
Domain Architecture
Description	Nuclear factor 1 X-type (Nuclear factor 1/X) (NF1-X) (NFI-X) (NF-I/X) (CCAAT-box-binding transcription factor) (CTF) (TGGCA-binding protein).

CNKR1_HUMAN
θ value	θ > 10 (rank : 67)	NC score	0.075895 (rank : 65)
Query Neighborhood Hits	66	Target Neighborhood Hits	154	Shared Neighborhood Hits	27
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

CYH3_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.077008 (rank : 63)
Query Neighborhood Hits	66	Target Neighborhood Hits	137	Shared Neighborhood Hits	41
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

DAPP1_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.075798 (rank : 66)
Query Neighborhood Hits	66	Target Neighborhood Hits	227	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 70)	NC score	0.081005 (rank : 62)
Query Neighborhood Hits	66	Target Neighborhood Hits	225	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DDEF1_MOUSE
θ value	θ > 10 (rank : 71)	NC score	0.051458 (rank : 77)
Query Neighborhood Hits	66	Target Neighborhood Hits	592	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

FGD5_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.056258 (rank : 73)
Query Neighborhood Hits	66	Target Neighborhood Hits	235	Shared Neighborhood Hits	23
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

FGD5_MOUSE
θ value	θ > 10 (rank : 73)	NC score	0.057586 (rank : 71)
Query Neighborhood Hits	66	Target Neighborhood Hits	170	Shared Neighborhood Hits	22
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

GAB2_HUMAN
θ value	θ > 10 (rank : 74)	NC score	0.069006 (rank : 68)
Query Neighborhood Hits	66	Target Neighborhood Hits	188	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

GNRP_MOUSE
θ value	θ > 10 (rank : 75)	NC score	0.061191 (rank : 70)
Query Neighborhood Hits	66	Target Neighborhood Hits	191	Shared Neighborhood Hits	29
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

OSBL2_HUMAN
θ value	θ > 10 (rank : 76)	NC score	0.309838 (rank : 18)
Query Neighborhood Hits	66	Target Neighborhood Hits	23	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H1P3, Q9BZB1, Q9Y4B8	Gene names	OSBPL2, KIAA0772, ORP2
Domain Architecture
Description	Oxysterol-binding protein-related protein 2 (OSBP-related protein 2) (ORP-2).

OSBL2_MOUSE
θ value	θ > 10 (rank : 77)	NC score	0.312950 (rank : 17)
Query Neighborhood Hits	66	Target Neighborhood Hits	22	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BX94, Q3TCK8, Q8R0H8	Gene names	Osbpl2
Domain Architecture
Description	Oxysterol-binding protein-related protein 2 (OSBP-related protein 2) (ORP-2).

OSBL5_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.270914 (rank : 20)
Query Neighborhood Hits	66	Target Neighborhood Hits	117	Shared Neighborhood Hits	23
SwissProt Accessions	Q9H0X9, Q9BZB0, Q9P1Z4	Gene names	OSBPL5, KIAA1534, ORP5
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5).

OSBL5_MOUSE
θ value	θ > 10 (rank : 79)	NC score	0.268618 (rank : 21)
Query Neighborhood Hits	66	Target Neighborhood Hits	77	Shared Neighborhood Hits	24
SwissProt Accessions	Q9ER64, Q8R510, Q99NF5	Gene names	Osbpl5, Obph1, Osbp2
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5) (Oxysterol-binding protein homolog 1).

OSBL8_HUMAN
θ value	θ > 10 (rank : 80)	NC score	0.272359 (rank : 19)
Query Neighborhood Hits	66	Target Neighborhood Hits	289	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BZF1, Q8WXP8, Q9P277	Gene names	OSBPL8, KIAA1451, ORP8, OSBP10
Domain Architecture
Description	Oxysterol-binding protein-related protein 8 (OSBP-related protein 8) (ORP-8).

PKHA1_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.105905 (rank : 45)
Query Neighborhood Hits	66	Target Neighborhood Hits	127	Shared Neighborhood Hits	37
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.109361 (rank : 40)
Query Neighborhood Hits	66	Target Neighborhood Hits	120	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA2_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.098600 (rank : 51)
Query Neighborhood Hits	66	Target Neighborhood Hits	119	Shared Neighborhood Hits	37
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PKHA2_MOUSE
θ value	θ > 10 (rank : 84)	NC score	0.106474 (rank : 44)
Query Neighborhood Hits	66	Target Neighborhood Hits	116	Shared Neighborhood Hits	38
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHA4_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.096303 (rank : 52)
Query Neighborhood Hits	66	Target Neighborhood Hits	283	Shared Neighborhood Hits	33
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_MOUSE
θ value	θ > 10 (rank : 86)	NC score	0.095806 (rank : 53)
Query Neighborhood Hits	66	Target Neighborhood Hits	202	Shared Neighborhood Hits	32
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHB1_HUMAN
θ value	θ > 10 (rank : 87)	NC score	0.056093 (rank : 74)
Query Neighborhood Hits	66	Target Neighborhood Hits	46	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

PKHB1_MOUSE
θ value	θ > 10 (rank : 88)	NC score	0.056724 (rank : 72)
Query Neighborhood Hits	66	Target Neighborhood Hits	47	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

PPCT_MOUSE
θ value	θ > 10 (rank : 89)	NC score	0.053098 (rank : 76)
Query Neighborhood Hits	66	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	P53808, Q9QZX0, Q9R058	Gene names	Pctp, Stard2
Domain Architecture
Description	Phosphatidylcholine transfer protein (PC-TP) (StAR-related lipid transfer protein 2) (StARD2) (START domain-containing protein 2).

RHG25_MOUSE
θ value	θ > 10 (rank : 90)	NC score	0.099079 (rank : 50)
Query Neighborhood Hits	66	Target Neighborhood Hits	492	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

Hits sorted by NC score

PKHA3_HUMAN
NC score	0.999962 (rank : 1)	θ value	4.4118e-156 (rank : 1)
Query Neighborhood Hits	66	Target Neighborhood Hits	66	Shared Neighborhood Hits	66
SwissProt Accessions	Q9HB20, Q86TQ1, Q9NXT3	Gene names	PLEKHA3, FAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

PKHA3_MOUSE
NC score	0.994189 (rank : 2)	θ value	3.06949e-141 (rank : 2)
Query Neighborhood Hits	66	Target Neighborhood Hits	67	Shared Neighborhood Hits	58
SwissProt Accessions	Q9ERS4	Gene names	Plekha3, Fapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 3 (Phosphoinositol 4-phosphate adaptor protein 1) (FAPP-1).

C43BP_HUMAN
NC score	0.670563 (rank : 3)	θ value	1.80466e-16 (rank : 5)
Query Neighborhood Hits	66	Target Neighborhood Hits	87	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y5P4, Q96Q85, Q96Q88, Q9H2S7, Q9H2S8	Gene names	COL4A3BP, STARD11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

C43BP_MOUSE
NC score	0.667545 (rank : 4)	θ value	1.80466e-16 (rank : 6)
Query Neighborhood Hits	66	Target Neighborhood Hits	91	Shared Neighborhood Hits	49
SwissProt Accessions	Q9EQG9, Q91WB1, Q9CU52, Q9EQG8	Gene names	Col4a3bp, Stard11
Domain Architecture
Description	Goodpasture antigen-binding protein (EC 2.7.11.9) (GPBP) (Collagen type IV alpha-3-binding protein) (StAR-related lipid transfer protein 11) (StARD11) (START domain-containing protein 11).

OSBL9_HUMAN
NC score	0.569052 (rank : 5)	θ value	1.38178e-16 (rank : 4)
Query Neighborhood Hits	66	Target Neighborhood Hits	138	Shared Neighborhood Hits	42
SwissProt Accessions	Q96SU4, Q9H9X2	Gene names	OSBPL9, ORP9, OSBP4
Domain Architecture
Description	Oxysterol-binding protein-related protein 9 (OSBP-related protein 9) (ORP-9).

OSBP1_HUMAN
NC score	0.564165 (rank : 6)	θ value	2.97466e-19 (rank : 3)
Query Neighborhood Hits	66	Target Neighborhood Hits	180	Shared Neighborhood Hits	52
SwissProt Accessions	P22059	Gene names	OSBP, OSBP1
Domain Architecture
Description	Oxysterol-binding protein 1.

OSBP2_HUMAN
NC score	0.543696 (rank : 7)	θ value	2.20605e-14 (rank : 7)
Query Neighborhood Hits	66	Target Neighborhood Hits	154	Shared Neighborhood Hits	50
SwissProt Accessions	Q969R2, O60396, Q9BY96, Q9BZF0	Gene names	OSBP2, KIAA1664, ORP4, OSBPL4
Domain Architecture
Description	Oxysterol-binding protein 2 (Oxysterol-binding protein-related protein 4) (OSBP-related protein 4) (ORP-4).

OSBP2_MOUSE
NC score	0.519765 (rank : 8)	θ value	1.2105e-12 (rank : 8)
Query Neighborhood Hits	66	Target Neighborhood Hits	150	Shared Neighborhood Hits	43
SwissProt Accessions	Q5QNQ6, Q8CF21	Gene names	Osbp2
Domain Architecture	No domain graphic available
Description	Oxysterol-binding protein 2.

OSB11_MOUSE
NC score	0.495263 (rank : 9)	θ value	8.97725e-08 (rank : 9)
Query Neighborhood Hits	66	Target Neighborhood Hits	71	Shared Neighborhood Hits	35
SwissProt Accessions	Q8CI95	Gene names	Osbpl11
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

OSB11_HUMAN
NC score	0.488577 (rank : 10)	θ value	1.99992e-07 (rank : 10)
Query Neighborhood Hits	66	Target Neighborhood Hits	60	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BXB4	Gene names	OSBPL11, ORP11, OSBP12
Domain Architecture
Description	Oxysterol-binding protein-related protein 11 (OSBP-related protein 11) (ORP-11).

OSB10_HUMAN
NC score	0.467698 (rank : 11)	θ value	1.29631e-06 (rank : 11)
Query Neighborhood Hits	66	Target Neighborhood Hits	55	Shared Neighborhood Hits	31
SwissProt Accessions	Q9BXB5, Q9BTU5	Gene names	OSBPL10, ORP10, OSBP9
Domain Architecture
Description	Oxysterol-binding protein-related protein 10 (OSBP-related protein 10) (ORP-10).

OSBL7_HUMAN
NC score	0.364992 (rank : 12)	θ value	0.00665767 (rank : 17)
Query Neighborhood Hits	66	Target Neighborhood Hits	71	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BZF2	Gene names	OSBPL7, ORP7
Domain Architecture
Description	Oxysterol-binding protein-related protein 7 (OSBP-related protein 7) (ORP-7).

OSBL6_HUMAN
NC score	0.351684 (rank : 13)	θ value	0.00665767 (rank : 15)
Query Neighborhood Hits	66	Target Neighborhood Hits	101	Shared Neighborhood Hits	21
SwissProt Accessions	Q9BZF3, Q7Z4Q1, Q96SR1	Gene names	OSBPL6, ORP6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

OSBL6_MOUSE
NC score	0.347939 (rank : 14)	θ value	0.00665767 (rank : 16)
Query Neighborhood Hits	66	Target Neighborhood Hits	105	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BXR9, Q8BYW2	Gene names	Osbpl6
Domain Architecture
Description	Oxysterol-binding protein-related protein 6 (OSBP-related protein 6) (ORP-6).

OSBL3_HUMAN
NC score	0.347549 (rank : 15)	θ value	0.125558 (rank : 27)
Query Neighborhood Hits	66	Target Neighborhood Hits	93	Shared Neighborhood Hits	32
SwissProt Accessions	Q9H4L5, O14591, O43357, O43358, Q8N702, Q8N703, Q8N704, Q8NFH0, Q8NFH1, Q8NI12, Q8NI13, Q9BZF4, Q9UED6	Gene names	OSBPL3, KIAA0704, ORP3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

OSBL3_MOUSE
NC score	0.347492 (rank : 16)	θ value	0.47712 (rank : 33)
Query Neighborhood Hits	66	Target Neighborhood Hits	86	Shared Neighborhood Hits	32
SwissProt Accessions	Q9DBS9	Gene names	Osbpl3, Orp3
Domain Architecture
Description	Oxysterol-binding protein-related protein 3 (OSBP-related protein 3) (ORP-3).

OSBL2_MOUSE
NC score	0.312950 (rank : 17)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	66	Target Neighborhood Hits	22	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BX94, Q3TCK8, Q8R0H8	Gene names	Osbpl2
Domain Architecture
Description	Oxysterol-binding protein-related protein 2 (OSBP-related protein 2) (ORP-2).

OSBL2_HUMAN
NC score	0.309838 (rank : 18)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	66	Target Neighborhood Hits	23	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H1P3, Q9BZB1, Q9Y4B8	Gene names	OSBPL2, KIAA0772, ORP2
Domain Architecture
Description	Oxysterol-binding protein-related protein 2 (OSBP-related protein 2) (ORP-2).

OSBL8_HUMAN
NC score	0.272359 (rank : 19)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	66	Target Neighborhood Hits	289	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BZF1, Q8WXP8, Q9P277	Gene names	OSBPL8, KIAA1451, ORP8, OSBP10
Domain Architecture
Description	Oxysterol-binding protein-related protein 8 (OSBP-related protein 8) (ORP-8).

OSBL5_HUMAN
NC score	0.270914 (rank : 20)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	66	Target Neighborhood Hits	117	Shared Neighborhood Hits	23
SwissProt Accessions	Q9H0X9, Q9BZB0, Q9P1Z4	Gene names	OSBPL5, KIAA1534, ORP5
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5).

OSBL5_MOUSE
NC score	0.268618 (rank : 21)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	66	Target Neighborhood Hits	77	Shared Neighborhood Hits	24
SwissProt Accessions	Q9ER64, Q8R510, Q99NF5	Gene names	Osbpl5, Obph1, Osbp2
Domain Architecture
Description	Oxysterol-binding protein-related protein 5 (OSBP-related protein 5) (ORP-5) (Oxysterol-binding protein homolog 1).

OSBL1_MOUSE
NC score	0.265860 (rank : 22)	θ value	0.0193708 (rank : 20)
Query Neighborhood Hits	66	Target Neighborhood Hits	336	Shared Neighborhood Hits	23
SwissProt Accessions	Q91XL9, O88318, Q3TH97, Q673L8, Q6DFU6	Gene names	Osbpl1a, Orp1, Orp1a
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

OSBL1_HUMAN
NC score	0.251980 (rank : 23)	θ value	0.0961366 (rank : 26)
Query Neighborhood Hits	66	Target Neighborhood Hits	368	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BXW6, Q9BZF5, Q9NW87	Gene names	OSBPL1A, ORP1, OSBP8, OSBPL1
Domain Architecture
Description	Oxysterol-binding protein-related protein 1 (OSBP-related protein 1) (ORP-1).

PLEK_MOUSE
NC score	0.221913 (rank : 24)	θ value	0.0431538 (rank : 23)
Query Neighborhood Hits	66	Target Neighborhood Hits	109	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

PLEK2_MOUSE
NC score	0.220516 (rank : 25)	θ value	0.47712 (rank : 35)
Query Neighborhood Hits	66	Target Neighborhood Hits	96	Shared Neighborhood Hits	43
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PLEK2_HUMAN
NC score	0.218846 (rank : 26)	θ value	0.47712 (rank : 34)
Query Neighborhood Hits	66	Target Neighborhood Hits	101	Shared Neighborhood Hits	43
SwissProt Accessions	Q9NYT0, Q96JT0	Gene names	PLEK2
Domain Architecture
Description	Pleckstrin-2.

PLEK_HUMAN
NC score	0.215318 (rank : 27)	θ value	0.0431538 (rank : 22)
Query Neighborhood Hits	66	Target Neighborhood Hits	110	Shared Neighborhood Hits	40
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

MTMRD_HUMAN
NC score	0.211070 (rank : 28)	θ value	5.44631e-05 (rank : 12)
Query Neighborhood Hits	66	Target Neighborhood Hits	135	Shared Neighborhood Hits	41
SwissProt Accessions	Q86WG5, Q3MJF0, Q68DQ3, Q6P459, Q6PJD1, Q7Z325, Q7Z621, Q86VE2, Q96FE2, Q9C097	Gene names	SBF2, CMT4B2, KIAA1766, MTMR13
Domain Architecture	No domain graphic available
Description	Myotubularin-related protein 13 (SET-binding factor 2).

PKHA6_HUMAN
NC score	0.189480 (rank : 29)	θ value	0.62314 (rank : 38)
Query Neighborhood Hits	66	Target Neighborhood Hits	556	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Y2H5	Gene names	PLEKHA6, KIAA0969, PEPP3
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

PKHA6_MOUSE
NC score	0.184231 (rank : 30)	θ value	0.365318 (rank : 32)
Query Neighborhood Hits	66	Target Neighborhood Hits	591	Shared Neighborhood Hits	44
SwissProt Accessions	Q7TQG1, Q8K0J5	Gene names	Plekha6, Pepp3
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 6 (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3).

SWP70_HUMAN
NC score	0.166522 (rank : 31)	θ value	0.00869519 (rank : 18)
Query Neighborhood Hits	66	Target Neighborhood Hits	973	Shared Neighborhood Hits	52
SwissProt Accessions	Q9UH65, O75135, Q7LCY6, Q9P061, Q9P0Z8	Gene names	SWAP70, KIAA0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

SWP70_MOUSE
NC score	0.160320 (rank : 32)	θ value	0.00869519 (rank : 19)
Query Neighborhood Hits	66	Target Neighborhood Hits	1097	Shared Neighborhood Hits	52
SwissProt Accessions	Q6A028, O88443, Q3TQR6, Q3UCA3, Q6P1D0	Gene names	Swap70, Kiaa0640
Domain Architecture	No domain graphic available
Description	Switch-associated protein 70 (SWAP-70).

MTMR5_HUMAN
NC score	0.158059 (rank : 33)	θ value	0.0431538 (rank : 21)
Query Neighborhood Hits	66	Target Neighborhood Hits	141	Shared Neighborhood Hits	35
SwissProt Accessions	O95248, O60228, Q5JXD8, Q5PPM2, Q96GR9, Q9UGB8	Gene names	SBF1, MTMR5
Domain Architecture
Description	SET-binding factor 1 (Sbf1) (Myotubularin-related protein 5).

PKHA5_HUMAN
NC score	0.140117 (rank : 34)	θ value	0.163984 (rank : 29)
Query Neighborhood Hits	66	Target Neighborhood Hits	455	Shared Neighborhood Hits	41
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

CYH4_MOUSE
NC score	0.126830 (rank : 35)	θ value	0.813845 (rank : 41)
Query Neighborhood Hits	66	Target Neighborhood Hits	134	Shared Neighborhood Hits	45
SwissProt Accessions	Q80YW0	Gene names	Pscd4
Domain Architecture	No domain graphic available
Description	Cytohesin-4.

CYH4_HUMAN
NC score	0.120341 (rank : 36)	θ value	2.36792 (rank : 46)
Query Neighborhood Hits	66	Target Neighborhood Hits	135	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UIA0, Q5R3F9, Q9UGT6	Gene names	PSCD4, CYT4
Domain Architecture
Description	Cytohesin-4.

FGD6_MOUSE
NC score	0.114734 (rank : 37)	θ value	0.00134147 (rank : 13)
Query Neighborhood Hits	66	Target Neighborhood Hits	282	Shared Neighborhood Hits	28
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

URP2_MOUSE
NC score	0.111844 (rank : 38)	θ value	0.21417 (rank : 31)
Query Neighborhood Hits	66	Target Neighborhood Hits	37	Shared Neighborhood Hits	13
SwissProt Accessions	Q8K1B8	Gene names	Urp2, Kind3
Domain Architecture
Description	Unc-112-related protein 2 (Kindlin-3).

FGD6_HUMAN
NC score	0.110838 (rank : 39)	θ value	0.00298849 (rank : 14)
Query Neighborhood Hits	66	Target Neighborhood Hits	237	Shared Neighborhood Hits	33
SwissProt Accessions	Q6ZV73, Q6ZR53, Q7Z2Z7, Q96D44, Q9NUR8, Q9P2I5	Gene names	FGD6, KIAA1362, ZFYVE24
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6 (Zinc finger FYVE domain-containing protein 24).

PKHA1_MOUSE
NC score	0.109361 (rank : 40)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	66	Target Neighborhood Hits	120	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

CEND1_HUMAN
NC score	0.109331 (rank : 41)	θ value	0.0563607 (rank : 24)
Query Neighborhood Hits	66	Target Neighborhood Hits	284	Shared Neighborhood Hits	38
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CNKR2_MOUSE
NC score	0.108039 (rank : 42)	θ value	0.813845 (rank : 40)
Query Neighborhood Hits	66	Target Neighborhood Hits	197	Shared Neighborhood Hits	32
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.107963 (rank : 43)	θ value	0.813845 (rank : 39)
Query Neighborhood Hits	66	Target Neighborhood Hits	197	Shared Neighborhood Hits	32
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

PKHA2_MOUSE
NC score	0.106474 (rank : 44)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	66	Target Neighborhood Hits	116	Shared Neighborhood Hits	38
SwissProt Accessions	Q9ERS5, Q8BY29	Gene names	Plekha2, Tapp2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2) (PH domain-containing adaptor PHAD47).

PKHA1_HUMAN
NC score	0.105905 (rank : 45)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	66	Target Neighborhood Hits	127	Shared Neighborhood Hits	37
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

CYH3_MOUSE
NC score	0.105013 (rank : 46)	θ value	4.03905 (rank : 53)
Query Neighborhood Hits	66	Target Neighborhood Hits	148	Shared Neighborhood Hits	47
SwissProt Accessions	O08967, Q8CI93	Gene names	Pscd3, Grp1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1) (CLM-3).

CEND2_HUMAN
NC score	0.102999 (rank : 47)	θ value	0.0961366 (rank : 25)
Query Neighborhood Hits	66	Target Neighborhood Hits	166	Shared Neighborhood Hits	28
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

RHG25_HUMAN
NC score	0.101485 (rank : 48)	θ value	5.27518 (rank : 57)
Query Neighborhood Hits	66	Target Neighborhood Hits	550	Shared Neighborhood Hits	47
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

URP2_HUMAN
NC score	0.100467 (rank : 49)	θ value	0.21417 (rank : 30)
Query Neighborhood Hits	66	Target Neighborhood Hits	30	Shared Neighborhood Hits	12
SwissProt Accessions	Q86UX7, Q8IUA1, Q8N207, Q9BT48	Gene names	URP2, KIND3, MIG2B
Domain Architecture
Description	Unc-112-related protein 2 (Kindlin-3) (MIG2-like).

RHG25_MOUSE
NC score	0.099079 (rank : 50)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	66	Target Neighborhood Hits	492	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

PKHA2_HUMAN
NC score	0.098600 (rank : 51)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	66	Target Neighborhood Hits	119	Shared Neighborhood Hits	37
SwissProt Accessions	Q9HB19	Gene names	PLEKHA2, TAPP2
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family A member 2 (Tandem PH domain-containing protein 2) (TAPP-2).

PKHA4_HUMAN
NC score	0.096303 (rank : 52)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	66	Target Neighborhood Hits	283	Shared Neighborhood Hits	33
SwissProt Accessions	Q9H4M7, Q8N4M8, Q8N658	Gene names	PLEKHA4, PEPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PKHA4_MOUSE
NC score	0.095806 (rank : 53)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	66	Target Neighborhood Hits	202	Shared Neighborhood Hits	32
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

CEND1_MOUSE
NC score	0.092790 (rank : 54)	θ value	0.163984 (rank : 28)
Query Neighborhood Hits	66	Target Neighborhood Hits	260	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

GAB2_MOUSE
NC score	0.088908 (rank : 55)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	66	Target Neighborhood Hits	220	Shared Neighborhood Hits	32
SwissProt Accessions	Q9Z1S8, Q9R1X3	Gene names	Gab2
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (PH domain-containing adaptor molecule p97).

MRIP_MOUSE
NC score	0.088057 (rank : 56)	θ value	3.0926 (rank : 49)
Query Neighborhood Hits	66	Target Neighborhood Hits	569	Shared Neighborhood Hits	36
SwissProt Accessions	P97434, Q3TBR5, Q3TC85, Q3TRS0, Q3U1Y8, Q3U3E4, Q5SWZ3, Q5SWZ4, Q5SWZ7, Q6P559, Q80YC8	Gene names	Mrip, Kiaa0864, Rhoip3
Domain Architecture
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (p116Rip) (RIP3).

CYH2_MOUSE
NC score	0.086258 (rank : 57)	θ value	4.03905 (rank : 52)
Query Neighborhood Hits	66	Target Neighborhood Hits	171	Shared Neighborhood Hits	43
SwissProt Accessions	P63034, O89099, P97695, Q3UP39	Gene names	Pscd2, Sec7b
Domain Architecture	No domain graphic available
Description	Cytohesin-2 (CLM2) (SEC7 homolog B) (msec7-2).

CYH2_HUMAN
NC score	0.086248 (rank : 58)	θ value	4.03905 (rank : 51)
Query Neighborhood Hits	66	Target Neighborhood Hits	175	Shared Neighborhood Hits	43
SwissProt Accessions	Q99418, Q92958	Gene names	PSCD2, ARNO
Domain Architecture
Description	Cytohesin-2 (ARF nucleotide-binding site opener) (ARNO protein) (ARF exchange factor).

CYH1_HUMAN
NC score	0.085928 (rank : 59)	θ value	6.88961 (rank : 61)
Query Neighborhood Hits	66	Target Neighborhood Hits	184	Shared Neighborhood Hits	46
SwissProt Accessions	Q15438, Q9P123, Q9P124	Gene names	PSCD1, D17S811E
Domain Architecture
Description	Cytohesin-1 (SEC7 homolog B2-1).

MRIP_HUMAN
NC score	0.082468 (rank : 60)	θ value	4.03905 (rank : 54)
Query Neighborhood Hits	66	Target Neighborhood Hits	578	Shared Neighborhood Hits	38
SwissProt Accessions	Q6WCQ1, Q3KQZ5, Q5FB94, Q6DHW2, Q7Z5Y2, Q8N390, Q96G40	Gene names	MRIP, KIAA0864, RHOIP3
Domain Architecture	No domain graphic available
Description	Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (M-RIP) (RIP3) (p116Rip).

CYH1_MOUSE
NC score	0.082145 (rank : 61)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	66	Target Neighborhood Hits	176	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QX11, O88817	Gene names	Pscd1
Domain Architecture
Description	Cytohesin-1 (CLM1).

DAPP1_MOUSE
NC score	0.081005 (rank : 62)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	66	Target Neighborhood Hits	225	Shared Neighborhood Hits	40
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

CYH3_HUMAN
NC score	0.077008 (rank : 63)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	66	Target Neighborhood Hits	137	Shared Neighborhood Hits	41
SwissProt Accessions	O43739	Gene names	PSCD3, ARNO3, GRP1
Domain Architecture
Description	Cytohesin-3 (ARF nucleotide-binding site opener 3) (ARNO3 protein) (General receptor of phosphoinositides 1) (Grp1).

TARA_MOUSE
NC score	0.076132 (rank : 64)	θ value	4.03905 (rank : 56)
Query Neighborhood Hits	66	Target Neighborhood Hits	1133	Shared Neighborhood Hits	36
SwissProt Accessions	Q99KW3, Q2PZW9, Q2Q402, Q2Q403, Q2Q404, Q6ZPK4, Q8C6T3, Q8CG90	Gene names	Triobp, Kiaa1662, Tara
Domain Architecture	No domain graphic available
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

CNKR1_HUMAN
NC score	0.075895 (rank : 65)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	66	Target Neighborhood Hits	154	Shared Neighborhood Hits	27
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

DAPP1_HUMAN
NC score	0.075798 (rank : 66)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	66	Target Neighborhood Hits	227	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

GNRP_HUMAN
NC score	0.069252 (rank : 67)	θ value	8.99809 (rank : 64)
Query Neighborhood Hits	66	Target Neighborhood Hits	239	Shared Neighborhood Hits	33
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GAB2_HUMAN
NC score	0.069006 (rank : 68)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	66	Target Neighborhood Hits	188	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UQC2, O60317	Gene names	GAB2, KIAA0571
Domain Architecture
Description	GRB2-associated-binding protein 2 (GRB2-associated binder 2) (pp100).

MYO10_HUMAN
NC score	0.063277 (rank : 69)	θ value	1.38821 (rank : 44)
Query Neighborhood Hits	66	Target Neighborhood Hits	920	Shared Neighborhood Hits	51
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

GNRP_MOUSE
NC score	0.061191 (rank : 70)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	66	Target Neighborhood Hits	191	Shared Neighborhood Hits	29
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

FGD5_MOUSE
NC score	0.057586 (rank : 71)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	66	Target Neighborhood Hits	170	Shared Neighborhood Hits	22
SwissProt Accessions	Q80UZ0, Q8BHM5	Gene names	Fgd5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5.

PKHB1_MOUSE
NC score	0.056724 (rank : 72)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	66	Target Neighborhood Hits	47	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QYE9, Q9QYB3, Q9QYB4, Q9QYD2, Q9QYD3	Gene names	Plekhb1, Phr1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

FGD5_HUMAN
NC score	0.056258 (rank : 73)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	66	Target Neighborhood Hits	235	Shared Neighborhood Hits	23
SwissProt Accessions	Q6ZNL6, Q6MZY1, Q7Z303, Q8IYP3, Q8N861, Q8N8G4	Gene names	FGD5, ZFYVE23
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23).

PKHB1_HUMAN
NC score	0.056093 (rank : 74)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	66	Target Neighborhood Hits	46	Shared Neighborhood Hits	27
SwissProt Accessions	Q9UF11, Q9UBF5, Q9UI37, Q9UI44	Gene names	PLEKHB1, KPL1, PHR1
Domain Architecture
Description	Pleckstrin homology domain-containing family B member 1 (Pleckstrin homology domain retinal protein 1) (PH domain-containing protein in retina 1) (PHRET1).

TARA_HUMAN
NC score	0.055187 (rank : 75)	θ value	3.0926 (rank : 50)
Query Neighborhood Hits	66	Target Neighborhood Hits	1626	Shared Neighborhood Hits	38
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

PPCT_MOUSE
NC score	0.053098 (rank : 76)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	66	Target Neighborhood Hits	13	Shared Neighborhood Hits	2
SwissProt Accessions	P53808, Q9QZX0, Q9R058	Gene names	Pctp, Stard2
Domain Architecture
Description	Phosphatidylcholine transfer protein (PC-TP) (StAR-related lipid transfer protein 2) (StARD2) (START domain-containing protein 2).

DDEF1_MOUSE
NC score	0.051458 (rank : 77)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	66	Target Neighborhood Hits	592	Shared Neighborhood Hits	21
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

HPS5_HUMAN
NC score	0.025871 (rank : 78)	θ value	2.36792 (rank : 47)
Query Neighborhood Hits	66	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UPZ3, O95942, Q8N4U0	Gene names	HPS5, AIBP63, KIAA1017
Domain Architecture	No domain graphic available
Description	Hermansky-Pudlak syndrome 5 protein (Alpha-integrin-binding protein 63) (Ruby-eye protein 2 homolog) (Ru2).

BMX_HUMAN
NC score	0.018713 (rank : 79)	θ value	0.62314 (rank : 36)
Query Neighborhood Hits	66	Target Neighborhood Hits	942	Shared Neighborhood Hits	29
SwissProt Accessions	P51813, O60564, Q12871	Gene names	BMX
Domain Architecture
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38).

OXR1_MOUSE
NC score	0.018339 (rank : 80)	θ value	4.03905 (rank : 55)
Query Neighborhood Hits	66	Target Neighborhood Hits	516	Shared Neighborhood Hits	4
SwissProt Accessions	Q4KMM3, Q5FWW1, Q99L06, Q99MK1, Q99MP4	Gene names	Oxr1, C7
Domain Architecture	No domain graphic available
Description	Oxidation resistance protein 1 (Protein C7).

BMX_MOUSE
NC score	0.017168 (rank : 81)	θ value	1.06291 (rank : 42)
Query Neighborhood Hits	66	Target Neighborhood Hits	912	Shared Neighborhood Hits	28
SwissProt Accessions	P97504	Gene names	Bmx
Domain Architecture	No domain graphic available
Description	Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein homolog).

ZP2_MOUSE
NC score	0.015100 (rank : 82)	θ value	5.27518 (rank : 59)
Query Neighborhood Hits	66	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	P20239	Gene names	Zp2, Zp-2, Zpa
Domain Architecture
Description	Zona pellucida sperm-binding protein 2 precursor (Zona pellucida glycoprotein ZP2) (Zona pellucida protein A).

ALMS1_MOUSE
NC score	0.014156 (rank : 83)	θ value	6.88961 (rank : 60)
Query Neighborhood Hits	66	Target Neighborhood Hits	181	Shared Neighborhood Hits	2
SwissProt Accessions	Q8K4E0, Q6A084, Q8C9N9	Gene names	Alms1, Kiaa0328
Domain Architecture	No domain graphic available
Description	Alstrom syndrome protein 1 homolog.

AKT1_HUMAN
NC score	0.012792 (rank : 84)	θ value	1.38821 (rank : 43)
Query Neighborhood Hits	66	Target Neighborhood Hits	885	Shared Neighborhood Hits	30
SwissProt Accessions	P31749, Q9BWB6	Gene names	AKT1, PKB, RAC
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT).

AKT1_MOUSE
NC score	0.012616 (rank : 85)	θ value	2.36792 (rank : 45)
Query Neighborhood Hits	66	Target Neighborhood Hits	878	Shared Neighborhood Hits	29
SwissProt Accessions	P31750, Q62274	Gene names	Akt1, Akt, Rac
Domain Architecture
Description	RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (RAC-PK-alpha) (AKT1 kinase) (Protein kinase B) (PKB) (C-AKT) (Thymoma viral proto- oncogene).

NFIX_MOUSE
NC score	0.012206 (rank : 86)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	66	Target Neighborhood Hits	35	Shared Neighborhood Hits	4
SwissProt Accessions	P70257, O08519, P70258, Q64192, Q99L78, Q9R1G2	Gene names	Nfix
Domain Architecture
Description	Nuclear factor 1 X-type (Nuclear factor 1/X) (NF1-X) (NFI-X) (NF-I/X) (CCAAT-box-binding transcription factor) (CTF) (TGGCA-binding protein).

NFIX_HUMAN
NC score	0.012104 (rank : 87)	θ value	8.99809 (rank : 65)
Query Neighborhood Hits	66	Target Neighborhood Hits	38	Shared Neighborhood Hits	4
SwissProt Accessions	Q14938, O60413, Q12859, Q13050, Q13052, Q9UPH1, Q9Y6R8	Gene names	NFIX
Domain Architecture
Description	Nuclear factor 1 X-type (Nuclear factor 1/X) (NF1-X) (NFI-X) (NF-I/X) (CCAAT-box-binding transcription factor) (CTF) (TGGCA-binding protein).

ITK_HUMAN
NC score	0.010927 (rank : 88)	θ value	3.0926 (rank : 48)
Query Neighborhood Hits	66	Target Neighborhood Hits	1016	Shared Neighborhood Hits	22
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

LAMA1_MOUSE
NC score	0.009872 (rank : 89)	θ value	0.62314 (rank : 37)
Query Neighborhood Hits	66	Target Neighborhood Hits	838	Shared Neighborhood Hits	3
SwissProt Accessions	P19137	Gene names	Lama1, Lama, Lama-1
Domain Architecture
Description	Laminin alpha-1 chain precursor (Laminin A chain).

SEPT9_HUMAN
NC score	0.005754 (rank : 90)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	66	Target Neighborhood Hits	706	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UHD8, Q96QF3, Q96QF4, Q96QF5, Q9HA04, Q9UG40, Q9Y5W4	Gene names	SEPT9, KIAA0991, MSF
Domain Architecture	No domain graphic available
Description	Septin-9 (MLL septin-like fusion protein) (MLL septin-like fusion protein MSF-A) (Ovarian/Breast septin) (Ov/Br septin) (Septin D1).