Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : RHG09_HUMAN

For an explanation of this page, click here

RHG09_HUMAN
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RHG09_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	186	Target Neighborhood Hits	186	Shared Neighborhood Hits	186
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

RHG12_HUMAN
θ value	1.65806e-78 (rank : 2)	NC score	0.933039 (rank : 2)
Query Neighborhood Hits	186	Target Neighborhood Hits	190	Shared Neighborhood Hits	102
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
θ value	1.65806e-78 (rank : 3)	NC score	0.930371 (rank : 3)
Query Neighborhood Hits	186	Target Neighborhood Hits	204	Shared Neighborhood Hits	104
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

CHIN_MOUSE
θ value	1.02001e-27 (rank : 4)	NC score	0.787705 (rank : 17)
Query Neighborhood Hits	186	Target Neighborhood Hits	229	Shared Neighborhood Hits	75
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIN_HUMAN
θ value	2.96777e-27 (rank : 5)	NC score	0.785585 (rank : 20)
Query Neighborhood Hits	186	Target Neighborhood Hits	227	Shared Neighborhood Hits	72
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

CHIO_MOUSE
θ value	3.87602e-27 (rank : 6)	NC score	0.815601 (rank : 8)
Query Neighborhood Hits	186	Target Neighborhood Hits	130	Shared Neighborhood Hits	62
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIO_HUMAN
θ value	6.61148e-27 (rank : 7)	NC score	0.786231 (rank : 19)
Query Neighborhood Hits	186	Target Neighborhood Hits	220	Shared Neighborhood Hits	72
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

TCGAP_HUMAN
θ value	9.54697e-26 (rank : 8)	NC score	0.723695 (rank : 35)
Query Neighborhood Hits	186	Target Neighborhood Hits	872	Shared Neighborhood Hits	103
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

ABR_HUMAN
θ value	1.24688e-25 (rank : 9)	NC score	0.768006 (rank : 28)
Query Neighborhood Hits	186	Target Neighborhood Hits	166	Shared Neighborhood Hits	71
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

TCGAP_MOUSE
θ value	1.24688e-25 (rank : 10)	NC score	0.812694 (rank : 10)
Query Neighborhood Hits	186	Target Neighborhood Hits	409	Shared Neighborhood Hits	89
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

OPHN1_MOUSE
θ value	3.75424e-22 (rank : 11)	NC score	0.806950 (rank : 13)
Query Neighborhood Hits	186	Target Neighborhood Hits	174	Shared Neighborhood Hits	63
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

RHG26_HUMAN
θ value	4.9032e-22 (rank : 12)	NC score	0.769929 (rank : 27)
Query Neighborhood Hits	186	Target Neighborhood Hits	281	Shared Neighborhood Hits	88
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

GRLF1_HUMAN
θ value	8.36355e-22 (rank : 13)	NC score	0.818477 (rank : 6)
Query Neighborhood Hits	186	Target Neighborhood Hits	167	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

OPHN1_HUMAN
θ value	8.36355e-22 (rank : 14)	NC score	0.807734 (rank : 12)
Query Neighborhood Hits	186	Target Neighborhood Hits	161	Shared Neighborhood Hits	65
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

RHG04_HUMAN
θ value	3.17815e-21 (rank : 15)	NC score	0.760478 (rank : 29)
Query Neighborhood Hits	186	Target Neighborhood Hits	307	Shared Neighborhood Hits	98
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

BCR_HUMAN
θ value	1.33526e-19 (rank : 16)	NC score	0.752034 (rank : 30)
Query Neighborhood Hits	186	Target Neighborhood Hits	204	Shared Neighborhood Hits	71
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

GMIP_MOUSE
θ value	2.97466e-19 (rank : 17)	NC score	0.834526 (rank : 4)
Query Neighborhood Hits	186	Target Neighborhood Hits	202	Shared Neighborhood Hits	71
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

RHG01_HUMAN
θ value	2.97466e-19 (rank : 18)	NC score	0.792516 (rank : 15)
Query Neighborhood Hits	186	Target Neighborhood Hits	75	Shared Neighborhood Hits	62
SwissProt Accessions	Q07960	Gene names	ARHGAP1, CDC42GAP, RHOGAP1
Domain Architecture
Description	Rho-GTPase-activating protein 1 (GTPase-activating protein rhoOGAP) (Rho-related small GTPase protein activator) (CDC42 GTPase-activating protein) (p50-RhoGAP).

GMIP_HUMAN
θ value	1.92812e-18 (rank : 19)	NC score	0.827561 (rank : 5)
Query Neighborhood Hits	186	Target Neighborhood Hits	225	Shared Neighborhood Hits	67
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

3BP1_HUMAN
θ value	9.56915e-18 (rank : 20)	NC score	0.802626 (rank : 14)
Query Neighborhood Hits	186	Target Neighborhood Hits	376	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

RHG05_MOUSE
θ value	9.56915e-18 (rank : 21)	NC score	0.783223 (rank : 21)
Query Neighborhood Hits	186	Target Neighborhood Hits	165	Shared Neighborhood Hits	66
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

SRGP2_HUMAN
θ value	4.74913e-17 (rank : 22)	NC score	0.740832 (rank : 31)
Query Neighborhood Hits	186	Target Neighborhood Hits	331	Shared Neighborhood Hits	98
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

RHG05_HUMAN
θ value	1.058e-16 (rank : 23)	NC score	0.774564 (rank : 23)
Query Neighborhood Hits	186	Target Neighborhood Hits	158	Shared Neighborhood Hits	64
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

MYO9B_MOUSE
θ value	1.38178e-16 (rank : 24)	NC score	0.427446 (rank : 59)
Query Neighborhood Hits	186	Target Neighborhood Hits	311	Shared Neighborhood Hits	69
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

3BP1_MOUSE
θ value	1.80466e-16 (rank : 25)	NC score	0.816716 (rank : 7)
Query Neighborhood Hits	186	Target Neighborhood Hits	238	Shared Neighborhood Hits	70
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

MYO9B_HUMAN
θ value	2.35696e-16 (rank : 26)	NC score	0.422442 (rank : 60)
Query Neighborhood Hits	186	Target Neighborhood Hits	641	Shared Neighborhood Hits	81
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

SRGP2_MOUSE
θ value	6.85773e-16 (rank : 27)	NC score	0.732884 (rank : 32)
Query Neighborhood Hits	186	Target Neighborhood Hits	324	Shared Neighborhood Hits	100
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

RBP1_MOUSE
θ value	8.95645e-16 (rank : 28)	NC score	0.730551 (rank : 33)
Query Neighborhood Hits	186	Target Neighborhood Hits	493	Shared Neighborhood Hits	65
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RHG08_HUMAN
θ value	1.16975e-15 (rank : 29)	NC score	0.773962 (rank : 25)
Query Neighborhood Hits	186	Target Neighborhood Hits	88	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NSG0, O75983, O95695, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NVX8, Q9NXL1, Q9UH20	Gene names	ARHGAP8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

RGAP1_HUMAN
θ value	1.52774e-15 (rank : 30)	NC score	0.814131 (rank : 9)
Query Neighborhood Hits	186	Target Neighborhood Hits	189	Shared Neighborhood Hits	64
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

CEND3_HUMAN
θ value	1.99529e-15 (rank : 31)	NC score	0.617545 (rank : 50)
Query Neighborhood Hits	186	Target Neighborhood Hits	275	Shared Neighborhood Hits	67
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

RBP1_HUMAN
θ value	3.40345e-15 (rank : 32)	NC score	0.713109 (rank : 38)
Query Neighborhood Hits	186	Target Neighborhood Hits	521	Shared Neighborhood Hits	65
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

CEND3_MOUSE
θ value	5.8054e-15 (rank : 33)	NC score	0.627304 (rank : 47)
Query Neighborhood Hits	186	Target Neighborhood Hits	228	Shared Neighborhood Hits	68
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

FNBP2_HUMAN
θ value	5.8054e-15 (rank : 34)	NC score	0.722695 (rank : 36)
Query Neighborhood Hits	186	Target Neighborhood Hits	432	Shared Neighborhood Hits	102
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

CEND2_HUMAN
θ value	7.58209e-15 (rank : 35)	NC score	0.660060 (rank : 44)
Query Neighborhood Hits	186	Target Neighborhood Hits	166	Shared Neighborhood Hits	65
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

RHG08_MOUSE
θ value	1.29331e-14 (rank : 36)	NC score	0.774057 (rank : 24)
Query Neighborhood Hits	186	Target Neighborhood Hits	73	Shared Neighborhood Hits	62
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

SRGP1_HUMAN
θ value	2.20605e-14 (rank : 37)	NC score	0.727598 (rank : 34)
Query Neighborhood Hits	186	Target Neighborhood Hits	390	Shared Neighborhood Hits	99
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

CEND1_MOUSE
θ value	1.86753e-13 (rank : 38)	NC score	0.574390 (rank : 53)
Query Neighborhood Hits	186	Target Neighborhood Hits	260	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

RHG18_MOUSE
θ value	4.16044e-13 (rank : 39)	NC score	0.772393 (rank : 26)
Query Neighborhood Hits	186	Target Neighborhood Hits	110	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

RGAP1_MOUSE
θ value	9.26847e-13 (rank : 40)	NC score	0.811033 (rank : 11)
Query Neighborhood Hits	186	Target Neighborhood Hits	185	Shared Neighborhood Hits	67
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

RHG07_HUMAN
θ value	7.84624e-12 (rank : 41)	NC score	0.668797 (rank : 43)
Query Neighborhood Hits	186	Target Neighborhood Hits	108	Shared Neighborhood Hits	62
SwissProt Accessions	Q96QB1, O14868, O43199, Q9C0E0	Gene names	DLC1, ARHGAP7, KIAA1723, STARD12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

RHG25_MOUSE
θ value	7.84624e-12 (rank : 42)	NC score	0.722564 (rank : 37)
Query Neighborhood Hits	186	Target Neighborhood Hits	492	Shared Neighborhood Hits	76
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

CEND1_HUMAN
θ value	2.28291e-11 (rank : 43)	NC score	0.550614 (rank : 54)
Query Neighborhood Hits	186	Target Neighborhood Hits	284	Shared Neighborhood Hits	63
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

RHG18_HUMAN
θ value	2.28291e-11 (rank : 44)	NC score	0.779803 (rank : 22)
Query Neighborhood Hits	186	Target Neighborhood Hits	90	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

RHG25_HUMAN
θ value	2.98157e-11 (rank : 45)	NC score	0.694114 (rank : 39)
Query Neighborhood Hits	186	Target Neighborhood Hits	550	Shared Neighborhood Hits	70
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RHG06_HUMAN
θ value	3.89403e-11 (rank : 46)	NC score	0.789746 (rank : 16)
Query Neighborhood Hits	186	Target Neighborhood Hits	114	Shared Neighborhood Hits	62
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

RHG06_MOUSE
θ value	5.08577e-11 (rank : 47)	NC score	0.787302 (rank : 18)
Query Neighborhood Hits	186	Target Neighborhood Hits	105	Shared Neighborhood Hits	62
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

P85A_HUMAN
θ value	1.133e-10 (rank : 48)	NC score	0.442862 (rank : 57)
Query Neighborhood Hits	186	Target Neighborhood Hits	479	Shared Neighborhood Hits	85
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

RHG07_MOUSE
θ value	1.9326e-10 (rank : 49)	NC score	0.672739 (rank : 42)
Query Neighborhood Hits	186	Target Neighborhood Hits	103	Shared Neighborhood Hits	62
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

P85A_MOUSE
θ value	1.25267e-09 (rank : 50)	NC score	0.436928 (rank : 58)
Query Neighborhood Hits	186	Target Neighborhood Hits	435	Shared Neighborhood Hits	86
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

CE005_HUMAN
θ value	2.79066e-09 (rank : 51)	NC score	0.633761 (rank : 45)
Query Neighborhood Hits	186	Target Neighborhood Hits	213	Shared Neighborhood Hits	61
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

CE005_MOUSE
θ value	4.76016e-09 (rank : 52)	NC score	0.630741 (rank : 46)
Query Neighborhood Hits	186	Target Neighborhood Hits	238	Shared Neighborhood Hits	62
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

STAR8_MOUSE
θ value	3.41135e-07 (rank : 53)	NC score	0.621074 (rank : 48)
Query Neighborhood Hits	186	Target Neighborhood Hits	101	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

STA13_HUMAN
θ value	7.59969e-07 (rank : 54)	NC score	0.620046 (rank : 49)
Query Neighborhood Hits	186	Target Neighborhood Hits	89	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

STA13_MOUSE
θ value	7.59969e-07 (rank : 55)	NC score	0.610885 (rank : 52)
Query Neighborhood Hits	186	Target Neighborhood Hits	89	Shared Neighborhood Hits	59
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

STAR8_HUMAN
θ value	1.29631e-06 (rank : 56)	NC score	0.614330 (rank : 51)
Query Neighborhood Hits	186	Target Neighborhood Hits	216	Shared Neighborhood Hits	73
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

TAGAP_HUMAN
θ value	1.69304e-06 (rank : 57)	NC score	0.683138 (rank : 40)
Query Neighborhood Hits	186	Target Neighborhood Hits	82	Shared Neighborhood Hits	61
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

K1688_HUMAN
θ value	0.000158464 (rank : 58)	NC score	0.524534 (rank : 56)
Query Neighborhood Hits	186	Target Neighborhood Hits	217	Shared Neighborhood Hits	67
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

SPTN4_HUMAN
θ value	0.000158464 (rank : 59)	NC score	0.071586 (rank : 129)
Query Neighborhood Hits	186	Target Neighborhood Hits	570	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

K1688_MOUSE
θ value	0.000461057 (rank : 60)	NC score	0.536518 (rank : 55)
Query Neighborhood Hits	186	Target Neighborhood Hits	188	Shared Neighborhood Hits	68
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

TAGAP_MOUSE
θ value	0.00102713 (rank : 61)	NC score	0.678193 (rank : 41)
Query Neighborhood Hits	186	Target Neighborhood Hits	83	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

SPN90_HUMAN
θ value	0.00390308 (rank : 62)	NC score	0.110844 (rank : 70)
Query Neighborhood Hits	186	Target Neighborhood Hits	157	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	0.00390308 (rank : 63)	NC score	0.103864 (rank : 75)
Query Neighborhood Hits	186	Target Neighborhood Hits	157	Shared Neighborhood Hits	33
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SPTA2_HUMAN
θ value	0.00665767 (rank : 64)	NC score	0.085757 (rank : 97)
Query Neighborhood Hits	186	Target Neighborhood Hits	888	Shared Neighborhood Hits	51
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

SPTB2_MOUSE
θ value	0.00665767 (rank : 65)	NC score	0.061342 (rank : 162)
Query Neighborhood Hits	186	Target Neighborhood Hits	770	Shared Neighborhood Hits	24
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

I5P2_HUMAN
θ value	0.00869519 (rank : 66)	NC score	0.340595 (rank : 61)
Query Neighborhood Hits	186	Target Neighborhood Hits	86	Shared Neighborhood Hits	52
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

ANM2_MOUSE
θ value	0.0252991 (rank : 67)	NC score	0.090753 (rank : 87)
Query Neighborhood Hits	186	Target Neighborhood Hits	175	Shared Neighborhood Hits	41
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

SPTB2_HUMAN
θ value	0.0252991 (rank : 68)	NC score	0.061468 (rank : 160)
Query Neighborhood Hits	186	Target Neighborhood Hits	748	Shared Neighborhood Hits	25
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

SPTN2_HUMAN
θ value	0.0252991 (rank : 69)	NC score	0.062081 (rank : 155)
Query Neighborhood Hits	186	Target Neighborhood Hits	535	Shared Neighborhood Hits	25
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

CSPG2_MOUSE
θ value	0.0563607 (rank : 70)	NC score	0.017831 (rank : 266)
Query Neighborhood Hits	186	Target Neighborhood Hits	711	Shared Neighborhood Hits	14
SwissProt Accessions	Q62059, Q62058, Q9CUU0	Gene names	Cspg2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M).

DDEF2_HUMAN
θ value	0.0563607 (rank : 71)	NC score	0.090060 (rank : 88)
Query Neighborhood Hits	186	Target Neighborhood Hits	599	Shared Neighborhood Hits	47
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

OCRL_HUMAN
θ value	0.0563607 (rank : 72)	NC score	0.322843 (rank : 62)
Query Neighborhood Hits	186	Target Neighborhood Hits	77	Shared Neighborhood Hits	52
SwissProt Accessions	Q01968, O60800, Q15684, Q15774, Q5JQF1, Q5JQF2, Q9UJG5, Q9UMA5	Gene names	OCRL, INPP5F, OCRL1
Domain Architecture
Description	Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein).

SRBS1_MOUSE
θ value	0.0563607 (rank : 73)	NC score	0.113390 (rank : 68)
Query Neighborhood Hits	186	Target Neighborhood Hits	409	Shared Neighborhood Hits	55
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

YES_MOUSE
θ value	0.0563607 (rank : 74)	NC score	0.043710 (rank : 223)
Query Neighborhood Hits	186	Target Neighborhood Hits	1052	Shared Neighborhood Hits	60
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FGR_MOUSE
θ value	0.0736092 (rank : 75)	NC score	0.043922 (rank : 222)
Query Neighborhood Hits	186	Target Neighborhood Hits	1069	Shared Neighborhood Hits	59
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

ANM2_HUMAN
θ value	0.0961366 (rank : 76)	NC score	0.087118 (rank : 95)
Query Neighborhood Hits	186	Target Neighborhood Hits	175	Shared Neighborhood Hits	41
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

FRMD5_HUMAN
θ value	0.0961366 (rank : 77)	NC score	0.017278 (rank : 268)
Query Neighborhood Hits	186	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

BLK_MOUSE
θ value	0.125558 (rank : 78)	NC score	0.027032 (rank : 247)
Query Neighborhood Hits	186	Target Neighborhood Hits	992	Shared Neighborhood Hits	47
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

FRK_HUMAN
θ value	0.163984 (rank : 79)	NC score	0.030466 (rank : 239)
Query Neighborhood Hits	186	Target Neighborhood Hits	1058	Shared Neighborhood Hits	55
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

YES_HUMAN
θ value	0.163984 (rank : 80)	NC score	0.042289 (rank : 225)
Query Neighborhood Hits	186	Target Neighborhood Hits	1059	Shared Neighborhood Hits	59
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ITSN1_MOUSE
θ value	0.21417 (rank : 81)	NC score	0.081654 (rank : 104)
Query Neighborhood Hits	186	Target Neighborhood Hits	1669	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

DLG4_HUMAN
θ value	0.279714 (rank : 82)	NC score	0.020244 (rank : 262)
Query Neighborhood Hits	186	Target Neighborhood Hits	286	Shared Neighborhood Hits	26
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

P85B_HUMAN
θ value	0.279714 (rank : 83)	NC score	0.156273 (rank : 63)
Query Neighborhood Hits	186	Target Neighborhood Hits	543	Shared Neighborhood Hits	52
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

SRC_HUMAN
θ value	0.279714 (rank : 84)	NC score	0.040164 (rank : 229)
Query Neighborhood Hits	186	Target Neighborhood Hits	1058	Shared Neighborhood Hits	59
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

DLG4_MOUSE
θ value	0.365318 (rank : 85)	NC score	0.019065 (rank : 263)
Query Neighborhood Hits	186	Target Neighborhood Hits	282	Shared Neighborhood Hits	25
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

PHC3_MOUSE
θ value	0.365318 (rank : 86)	NC score	0.032654 (rank : 238)
Query Neighborhood Hits	186	Target Neighborhood Hits	194	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CHP6, Q3TLV5	Gene names	Phc3
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 3.

SRBS1_HUMAN
θ value	0.365318 (rank : 87)	NC score	0.114979 (rank : 67)
Query Neighborhood Hits	186	Target Neighborhood Hits	396	Shared Neighborhood Hits	57
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

AHI1_MOUSE
θ value	0.47712 (rank : 88)	NC score	0.064232 (rank : 141)
Query Neighborhood Hits	186	Target Neighborhood Hits	496	Shared Neighborhood Hits	48
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ITCH_HUMAN
θ value	0.47712 (rank : 89)	NC score	0.038172 (rank : 234)
Query Neighborhood Hits	186	Target Neighborhood Hits	162	Shared Neighborhood Hits	22
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

PHC3_HUMAN
θ value	0.47712 (rank : 90)	NC score	0.030378 (rank : 240)
Query Neighborhood Hits	186	Target Neighborhood Hits	218	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NDX5, Q5HYF0, Q6NSG2, Q8NFT7, Q8NFZ1, Q8TBM2, Q9H971, Q9H9I4	Gene names	PHC3, EDR3, PH3
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 3 (hPH3) (Homolog of polyhomeotic 3) (Early development regulatory protein 3).

PLEK_MOUSE
θ value	0.47712 (rank : 91)	NC score	0.048242 (rank : 218)
Query Neighborhood Hits	186	Target Neighborhood Hits	109	Shared Neighborhood Hits	15
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

ITCH_MOUSE
θ value	0.62314 (rank : 92)	NC score	0.038903 (rank : 233)
Query Neighborhood Hits	186	Target Neighborhood Hits	127	Shared Neighborhood Hits	22
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

RGS3_HUMAN
θ value	0.62314 (rank : 93)	NC score	0.026354 (rank : 248)
Query Neighborhood Hits	186	Target Neighborhood Hits	1375	Shared Neighborhood Hits	48
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

ROBO4_HUMAN
θ value	0.62314 (rank : 94)	NC score	0.007487 (rank : 290)
Query Neighborhood Hits	186	Target Neighborhood Hits	364	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WZ75, Q8TEG1, Q96JV6, Q9H718, Q9NWJ8	Gene names	ROBO4
Domain Architecture
Description	Roundabout homolog 4 precursor (Magic roundabout).

SYP2L_MOUSE
θ value	0.62314 (rank : 95)	NC score	0.021395 (rank : 258)
Query Neighborhood Hits	186	Target Neighborhood Hits	289	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

5NT1B_HUMAN
θ value	0.813845 (rank : 96)	NC score	0.022633 (rank : 254)
Query Neighborhood Hits	186	Target Neighborhood Hits	83	Shared Neighborhood Hits	5
SwissProt Accessions	Q96P26, Q8N9W3, Q8NA26, Q96DU5, Q96KE6, Q96M25, Q96SA3	Gene names	NT5C1B, AIRP
Domain Architecture
Description	Cytosolic 5'-nucleotidase 1B (EC 3.1.3.5) (Cytosolic 5'-nucleotidase IB) (cN1B) (cN-IB) (Autoimmune infertility-related protein).

CNKR1_HUMAN
θ value	0.813845 (rank : 97)	NC score	0.044343 (rank : 221)
Query Neighborhood Hits	186	Target Neighborhood Hits	154	Shared Neighborhood Hits	13
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

FYN_HUMAN
θ value	0.813845 (rank : 98)	NC score	0.039144 (rank : 232)
Query Neighborhood Hits	186	Target Neighborhood Hits	1078	Shared Neighborhood Hits	58
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	0.813845 (rank : 99)	NC score	0.040515 (rank : 228)
Query Neighborhood Hits	186	Target Neighborhood Hits	1073	Shared Neighborhood Hits	59
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

GSCR1_HUMAN
θ value	0.813845 (rank : 100)	NC score	0.034439 (rank : 235)
Query Neighborhood Hits	186	Target Neighborhood Hits	674	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

HIC2_HUMAN
θ value	0.813845 (rank : 101)	NC score	-0.004135 (rank : 307)
Query Neighborhood Hits	186	Target Neighborhood Hits	820	Shared Neighborhood Hits	8
SwissProt Accessions	Q96JB3, Q96KR3, Q9NSM9, Q9UPX9	Gene names	HIC2, HRG22, KIAA1020, ZBTB30
Domain Architecture
Description	Hypermethylated in cancer 2 protein (Hic-2) (Hic-3) (HIC1-related gene on chromosome 22) (Zinc finger and BTB domain-containing protein 30).

P85B_MOUSE
θ value	0.813845 (rank : 102)	NC score	0.124102 (rank : 64)
Query Neighborhood Hits	186	Target Neighborhood Hits	519	Shared Neighborhood Hits	49
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PGCB_MOUSE
θ value	0.813845 (rank : 103)	NC score	0.011168 (rank : 281)
Query Neighborhood Hits	186	Target Neighborhood Hits	459	Shared Neighborhood Hits	7
SwissProt Accessions	Q61361	Gene names	Bcan
Domain Architecture
Description	Brevican core protein precursor.

YLPM1_HUMAN
θ value	0.813845 (rank : 104)	NC score	0.030338 (rank : 241)
Query Neighborhood Hits	186	Target Neighborhood Hits	670	Shared Neighborhood Hits	22
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

BLK_HUMAN
θ value	1.06291 (rank : 105)	NC score	0.025649 (rank : 252)
Query Neighborhood Hits	186	Target Neighborhood Hits	994	Shared Neighborhood Hits	49
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

CRKL_MOUSE
θ value	1.06291 (rank : 106)	NC score	0.097915 (rank : 77)
Query Neighborhood Hits	186	Target Neighborhood Hits	307	Shared Neighborhood Hits	55
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

FGR_HUMAN
θ value	1.06291 (rank : 107)	NC score	0.043616 (rank : 224)
Query Neighborhood Hits	186	Target Neighborhood Hits	1067	Shared Neighborhood Hits	59
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

GA2L2_MOUSE
θ value	1.06291 (rank : 108)	NC score	0.017423 (rank : 267)
Query Neighborhood Hits	186	Target Neighborhood Hits	395	Shared Neighborhood Hits	18
SwissProt Accessions	Q5SSG4	Gene names	Gas2l2
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2).

ITSN1_HUMAN
θ value	1.06291 (rank : 109)	NC score	0.080561 (rank : 107)
Query Neighborhood Hits	186	Target Neighborhood Hits	1757	Shared Neighborhood Hits	89
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

MAGC1_HUMAN
θ value	1.06291 (rank : 110)	NC score	0.010972 (rank : 282)
Query Neighborhood Hits	186	Target Neighborhood Hits	431	Shared Neighborhood Hits	13
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

NCF1_HUMAN
θ value	1.06291 (rank : 111)	NC score	0.063743 (rank : 145)
Query Neighborhood Hits	186	Target Neighborhood Hits	198	Shared Neighborhood Hits	42
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NFAC2_HUMAN
θ value	1.06291 (rank : 112)	NC score	0.021478 (rank : 257)
Query Neighborhood Hits	186	Target Neighborhood Hits	101	Shared Neighborhood Hits	9
SwissProt Accessions	Q13469, Q13468, Q5TFW7, Q5TFW8, Q9NPX6, Q9NQH3, Q9UJR2	Gene names	NFATC2, NFAT1, NFATP
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 2 (T cell transcription factor NFAT1) (NFAT pre-existing subunit) (NF-ATp).

PIN1_MOUSE
θ value	1.06291 (rank : 113)	NC score	0.044560 (rank : 220)
Query Neighborhood Hits	186	Target Neighborhood Hits	60	Shared Neighborhood Hits	14
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

SPTA1_MOUSE
θ value	1.06291 (rank : 114)	NC score	0.081862 (rank : 103)
Query Neighborhood Hits	186	Target Neighborhood Hits	675	Shared Neighborhood Hits	55
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

BTK_HUMAN
θ value	1.38821 (rank : 115)	NC score	0.032888 (rank : 237)
Query Neighborhood Hits	186	Target Neighborhood Hits	1026	Shared Neighborhood Hits	53
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

CSKI2_MOUSE
θ value	1.38821 (rank : 116)	NC score	0.020511 (rank : 261)
Query Neighborhood Hits	186	Target Neighborhood Hits	812	Shared Neighborhood Hits	32
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

ITSN2_HUMAN
θ value	1.38821 (rank : 117)	NC score	0.077733 (rank : 113)
Query Neighborhood Hits	186	Target Neighborhood Hits	1173	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

K2002_HUMAN
θ value	1.38821 (rank : 118)	NC score	0.022256 (rank : 255)
Query Neighborhood Hits	186	Target Neighborhood Hits	274	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H792, Q6ZS78, Q8NCM3	Gene names	KIAA2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

NFAC2_MOUSE
θ value	1.38821 (rank : 119)	NC score	0.020629 (rank : 260)
Query Neighborhood Hits	186	Target Neighborhood Hits	98	Shared Neighborhood Hits	10
SwissProt Accessions	Q60591, Q60984, Q60985	Gene names	Nfatc2, Nfat1, Nfatp
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 2 (T cell transcription factor NFAT1) (NFAT pre-existing subunit) (NF-ATp).

PIN1_HUMAN
θ value	1.38821 (rank : 120)	NC score	0.039507 (rank : 230)
Query Neighborhood Hits	186	Target Neighborhood Hits	59	Shared Neighborhood Hits	13
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PLEK_HUMAN
θ value	1.38821 (rank : 121)	NC score	0.052249 (rank : 208)
Query Neighborhood Hits	186	Target Neighborhood Hits	110	Shared Neighborhood Hits	17
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

CELR3_HUMAN
θ value	1.81305 (rank : 122)	NC score	-0.000268 (rank : 301)
Query Neighborhood Hits	186	Target Neighborhood Hits	680	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NYQ7, O75092	Gene names	CELSR3, CDHF11, EGFL1, FMI1, KIAA0812, MEGF2
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 3 precursor (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains 2) (Epidermal growth factor-like 1).

ITSN2_MOUSE
θ value	1.81305 (rank : 123)	NC score	0.075395 (rank : 123)
Query Neighborhood Hits	186	Target Neighborhood Hits	1371	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

KLC2_HUMAN
θ value	1.81305 (rank : 124)	NC score	0.008305 (rank : 289)
Query Neighborhood Hits	186	Target Neighborhood Hits	227	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H0B6, Q9H9C8, Q9HA20	Gene names	KLC2
Domain Architecture
Description	Kinesin light chain 2 (KLC 2).

SRMS_MOUSE
θ value	1.81305 (rank : 125)	NC score	0.016049 (rank : 269)
Query Neighborhood Hits	186	Target Neighborhood Hits	964	Shared Neighborhood Hits	37
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

TEC_HUMAN
θ value	1.81305 (rank : 126)	NC score	0.026258 (rank : 249)
Query Neighborhood Hits	186	Target Neighborhood Hits	1006	Shared Neighborhood Hits	49
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

VINEX_MOUSE
θ value	1.81305 (rank : 127)	NC score	0.115280 (rank : 66)
Query Neighborhood Hits	186	Target Neighborhood Hits	286	Shared Neighborhood Hits	53
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

YAP1_HUMAN
θ value	1.81305 (rank : 128)	NC score	0.039321 (rank : 231)
Query Neighborhood Hits	186	Target Neighborhood Hits	173	Shared Neighborhood Hits	21
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

C2TA_MOUSE
θ value	2.36792 (rank : 129)	NC score	0.011381 (rank : 280)
Query Neighborhood Hits	186	Target Neighborhood Hits	131	Shared Neighborhood Hits	4
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

FOXO4_HUMAN
θ value	2.36792 (rank : 130)	NC score	0.005951 (rank : 291)
Query Neighborhood Hits	186	Target Neighborhood Hits	197	Shared Neighborhood Hits	6
SwissProt Accessions	P98177, O43821, Q13720, Q3KPF1, Q8TDK9	Gene names	MLLT7, AFX, AFX1, FOXO4
Domain Architecture
Description	Fork head domain transcription factor AFX1 (Forkhead box protein O4).

GAS7_HUMAN
θ value	2.36792 (rank : 131)	NC score	0.052279 (rank : 207)
Query Neighborhood Hits	186	Target Neighborhood Hits	258	Shared Neighborhood Hits	22
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

GCP60_HUMAN
θ value	2.36792 (rank : 132)	NC score	0.015710 (rank : 270)
Query Neighborhood Hits	186	Target Neighborhood Hits	419	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H3P7, Q5VTJ0, Q6P9F1, Q8IZC5, Q8N4D6, Q9H6U3	Gene names	ACBD3, GCP60
Domain Architecture	No domain graphic available
Description	Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi phosphoprotein 1) (GOLPH1) (Golgi complex-associated protein 1) (GOCAP1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7).

K2002_MOUSE
θ value	2.36792 (rank : 133)	NC score	0.021773 (rank : 256)
Query Neighborhood Hits	186	Target Neighborhood Hits	267	Shared Neighborhood Hits	5
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

MAST2_HUMAN
θ value	2.36792 (rank : 134)	NC score	-0.000138 (rank : 300)
Query Neighborhood Hits	186	Target Neighborhood Hits	1189	Shared Neighborhood Hits	34
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

ARHG4_HUMAN
θ value	3.0926 (rank : 135)	NC score	0.066500 (rank : 136)
Query Neighborhood Hits	186	Target Neighborhood Hits	242	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

BC11B_HUMAN
θ value	3.0926 (rank : 136)	NC score	-0.003360 (rank : 306)
Query Neighborhood Hits	186	Target Neighborhood Hits	761	Shared Neighborhood Hits	7
SwissProt Accessions	Q9C0K0, Q9H162	Gene names	BCL11B, CTIP2, RIT1
Domain Architecture	No domain graphic available
Description	B-cell lymphoma/leukemia 11B (B-cell CLL/lymphoma 11B) (Radiation- induced tumor suppressor gene 1 protein) (hRit1) (COUP-TF-interacting protein 2).

FOG1_HUMAN
θ value	3.0926 (rank : 137)	NC score	0.003549 (rank : 297)
Query Neighborhood Hits	186	Target Neighborhood Hits	981	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IX07	Gene names	ZFPM1, FOG1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

FRMD5_MOUSE
θ value	3.0926 (rank : 138)	NC score	0.012523 (rank : 278)
Query Neighborhood Hits	186	Target Neighborhood Hits	55	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

MLL3_MOUSE
θ value	3.0926 (rank : 139)	NC score	0.015015 (rank : 272)
Query Neighborhood Hits	186	Target Neighborhood Hits	1399	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

S12A6_HUMAN
θ value	3.0926 (rank : 140)	NC score	0.005821 (rank : 292)
Query Neighborhood Hits	186	Target Neighborhood Hits	58	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UHW9, Q8TDD4, Q9UFR2, Q9Y642, Q9Y665	Gene names	SLC12A6, KCC3
Domain Architecture
Description	Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3).

TSC2_HUMAN
θ value	3.0926 (rank : 141)	NC score	0.012037 (rank : 279)
Query Neighborhood Hits	186	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	P49815, O75275, Q8TAZ1	Gene names	TSC2
Domain Architecture
Description	Tuberin (Tuberous sclerosis 2 protein).

WBP4_MOUSE
θ value	3.0926 (rank : 142)	NC score	0.040827 (rank : 227)
Query Neighborhood Hits	186	Target Neighborhood Hits	100	Shared Neighborhood Hits	16
SwissProt Accessions	Q61048, Q8K1Z9, Q9CS45	Gene names	Wbp4, Fbp21, Fnbp21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

ARBK1_HUMAN
θ value	4.03905 (rank : 143)	NC score	-0.000940 (rank : 303)
Query Neighborhood Hits	186	Target Neighborhood Hits	859	Shared Neighborhood Hits	19
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

CT075_MOUSE
θ value	4.03905 (rank : 144)	NC score	0.004450 (rank : 295)
Query Neighborhood Hits	186	Target Neighborhood Hits	358	Shared Neighborhood Hits	8
SwissProt Accessions	P59383	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf75 homolog precursor.

GGN_HUMAN
θ value	4.03905 (rank : 145)	NC score	0.026109 (rank : 250)
Query Neighborhood Hits	186	Target Neighborhood Hits	269	Shared Neighborhood Hits	16
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

NCF2_HUMAN
θ value	4.03905 (rank : 146)	NC score	0.087487 (rank : 93)
Query Neighborhood Hits	186	Target Neighborhood Hits	229	Shared Neighborhood Hits	48
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NED4L_HUMAN
θ value	4.03905 (rank : 147)	NC score	0.028222 (rank : 244)
Query Neighborhood Hits	186	Target Neighborhood Hits	238	Shared Neighborhood Hits	23
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_MOUSE
θ value	4.03905 (rank : 148)	NC score	0.027858 (rank : 245)
Query Neighborhood Hits	186	Target Neighborhood Hits	231	Shared Neighborhood Hits	22
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

RCOR3_HUMAN
θ value	4.03905 (rank : 149)	NC score	0.014244 (rank : 275)
Query Neighborhood Hits	186	Target Neighborhood Hits	161	Shared Neighborhood Hits	12
SwissProt Accessions	Q9P2K3, Q5VT47, Q7L9I5, Q8N5U3, Q9NV83	Gene names	RCOR3, KIAA1343
Domain Architecture	No domain graphic available
Description	REST corepressor 3.

RCOR3_MOUSE
θ value	4.03905 (rank : 150)	NC score	0.014482 (rank : 274)
Query Neighborhood Hits	186	Target Neighborhood Hits	110	Shared Neighborhood Hits	8
SwissProt Accessions	Q6PGA0	Gene names	Rcor3
Domain Architecture	No domain graphic available
Description	REST corepressor 3.

RIMS2_HUMAN
θ value	4.03905 (rank : 151)	NC score	0.009124 (rank : 286)
Query Neighborhood Hits	186	Target Neighborhood Hits	342	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

TF65_HUMAN
θ value	4.03905 (rank : 152)	NC score	0.008899 (rank : 287)
Query Neighborhood Hits	186	Target Neighborhood Hits	115	Shared Neighborhood Hits	9
SwissProt Accessions	Q04206, Q6SLK1	Gene names	RELA, NFKB3
Domain Architecture
Description	Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit).

TTBK1_HUMAN
θ value	4.03905 (rank : 153)	NC score	0.010709 (rank : 284)
Query Neighborhood Hits	186	Target Neighborhood Hits	1058	Shared Neighborhood Hits	34
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

VINEX_HUMAN
θ value	4.03905 (rank : 154)	NC score	0.109770 (rank : 71)
Query Neighborhood Hits	186	Target Neighborhood Hits	270	Shared Neighborhood Hits	50
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

ZDHC8_HUMAN
θ value	4.03905 (rank : 155)	NC score	0.005282 (rank : 293)
Query Neighborhood Hits	186	Target Neighborhood Hits	234	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ULC8, Q6ICL1, Q6ZNF5, Q7Z6L9	Gene names	ZDHHC8, KIAA1292, ZDHHCL1, ZNF378
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC8 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378).

ARBK1_MOUSE
θ value	5.27518 (rank : 156)	NC score	-0.001521 (rank : 304)
Query Neighborhood Hits	186	Target Neighborhood Hits	849	Shared Neighborhood Hits	18
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

CTND1_MOUSE
θ value	5.27518 (rank : 157)	NC score	0.004997 (rank : 294)
Query Neighborhood Hits	186	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	P30999	Gene names	Ctnnd1, Catns
Domain Architecture
Description	Catenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Src substrate) (CAS) (p120(cas)).

CUTL2_HUMAN
θ value	5.27518 (rank : 158)	NC score	0.009435 (rank : 285)
Query Neighborhood Hits	186	Target Neighborhood Hits	906	Shared Neighborhood Hits	24
SwissProt Accessions	O14529	Gene names	CUTL2, KIAA0293
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

MLL2_HUMAN
θ value	5.27518 (rank : 159)	NC score	0.018923 (rank : 264)
Query Neighborhood Hits	186	Target Neighborhood Hits	1788	Shared Neighborhood Hits	48
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

NCF4_MOUSE
θ value	5.27518 (rank : 160)	NC score	0.087877 (rank : 92)
Query Neighborhood Hits	186	Target Neighborhood Hits	177	Shared Neighborhood Hits	39
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NEDD4_HUMAN
θ value	5.27518 (rank : 161)	NC score	0.027494 (rank : 246)
Query Neighborhood Hits	186	Target Neighborhood Hits	214	Shared Neighborhood Hits	19
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

RBNS5_HUMAN
θ value	5.27518 (rank : 162)	NC score	0.008361 (rank : 288)
Query Neighborhood Hits	186	Target Neighborhood Hits	242	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

SMUF2_HUMAN
θ value	5.27518 (rank : 163)	NC score	0.029497 (rank : 242)
Query Neighborhood Hits	186	Target Neighborhood Hits	142	Shared Neighborhood Hits	19
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SRRM1_MOUSE
θ value	5.27518 (rank : 164)	NC score	0.028485 (rank : 243)
Query Neighborhood Hits	186	Target Neighborhood Hits	966	Shared Neighborhood Hits	36
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

TJAP1_MOUSE
θ value	5.27518 (rank : 165)	NC score	0.010792 (rank : 283)
Query Neighborhood Hits	186	Target Neighborhood Hits	295	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DCD5, Q8CFL7, Q8R5I2	Gene names	Tjap1, Pilt, Tjp4
Domain Architecture	No domain graphic available
Description	Tight junction-associated protein 1 (Tight junction protein 4) (Protein incorporated later into tight junctions).

UBP2L_HUMAN
θ value	5.27518 (rank : 166)	NC score	0.013540 (rank : 276)
Query Neighborhood Hits	186	Target Neighborhood Hits	170	Shared Neighborhood Hits	8
SwissProt Accessions	Q14157, Q5VU75, Q5VU76, Q9BTU3, Q9UGL5	Gene names	UBAP2L, KIAA0144, NICE4
Domain Architecture
Description	Ubiquitin-associated protein 2-like (Protein NICE-4).

ARHG7_MOUSE
θ value	6.88961 (rank : 167)	NC score	0.076403 (rank : 119)
Query Neighborhood Hits	186	Target Neighborhood Hits	396	Shared Neighborhood Hits	49
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

AZI1_MOUSE
θ value	6.88961 (rank : 168)	NC score	0.015342 (rank : 271)
Query Neighborhood Hits	186	Target Neighborhood Hits	990	Shared Neighborhood Hits	23
SwissProt Accessions	Q62036	Gene names	Azi1, Az1, Azi
Domain Architecture
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1).

CENG1_MOUSE
θ value	6.88961 (rank : 169)	NC score	0.059602 (rank : 166)
Query Neighborhood Hits	186	Target Neighborhood Hits	531	Shared Neighborhood Hits	23
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

CRKL_HUMAN
θ value	6.88961 (rank : 170)	NC score	0.102521 (rank : 76)
Query Neighborhood Hits	186	Target Neighborhood Hits	313	Shared Neighborhood Hits	56
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

GAS7_MOUSE
θ value	6.88961 (rank : 171)	NC score	0.052487 (rank : 206)
Query Neighborhood Hits	186	Target Neighborhood Hits	259	Shared Neighborhood Hits	22
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

K1802_HUMAN
θ value	6.88961 (rank : 172)	NC score	0.014560 (rank : 273)
Query Neighborhood Hits	186	Target Neighborhood Hits	1378	Shared Neighborhood Hits	38
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

NCOA6_MOUSE
θ value	6.88961 (rank : 173)	NC score	0.018358 (rank : 265)
Query Neighborhood Hits	186	Target Neighborhood Hits	1076	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

NOXO1_MOUSE
θ value	6.88961 (rank : 174)	NC score	0.047076 (rank : 219)
Query Neighborhood Hits	186	Target Neighborhood Hits	114	Shared Neighborhood Hits	26
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

PHLPP_MOUSE
θ value	6.88961 (rank : 175)	NC score	0.000041 (rank : 299)
Query Neighborhood Hits	186	Target Neighborhood Hits	394	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CHE4, Q6PCN0, Q8QZU8, Q8R5E5, Q99KL6	Gene names	Phlpp, Kiaa0606, Plekhe1, Scop
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein).

PRDM2_HUMAN
θ value	6.88961 (rank : 176)	NC score	-0.002687 (rank : 305)
Query Neighborhood Hits	186	Target Neighborhood Hits	1135	Shared Neighborhood Hits	21
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

TIAM1_HUMAN
θ value	6.88961 (rank : 177)	NC score	0.049490 (rank : 217)
Query Neighborhood Hits	186	Target Neighborhood Hits	225	Shared Neighborhood Hits	22
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

ABCA7_HUMAN
θ value	8.99809 (rank : 178)	NC score	0.000702 (rank : 298)
Query Neighborhood Hits	186	Target Neighborhood Hits	144	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IZY2, Q96S58, Q9BZC4, Q9NR73, Q9UKP8	Gene names	ABCA7
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 7 (Macrophage ABC transporter) (Autoantigen SS-N) (ABCA-SSN).

MILK1_MOUSE
θ value	8.99809 (rank : 179)	NC score	0.033246 (rank : 236)
Query Neighborhood Hits	186	Target Neighborhood Hits	788	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

NACAM_MOUSE
θ value	8.99809 (rank : 180)	NC score	0.025683 (rank : 251)
Query Neighborhood Hits	186	Target Neighborhood Hits	1866	Shared Neighborhood Hits	57
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

NPAS2_MOUSE
θ value	8.99809 (rank : 181)	NC score	0.003901 (rank : 296)
Query Neighborhood Hits	186	Target Neighborhood Hits	132	Shared Neighborhood Hits	6
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

OGFR_HUMAN
θ value	8.99809 (rank : 182)	NC score	0.023301 (rank : 253)
Query Neighborhood Hits	186	Target Neighborhood Hits	1582	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

PHLB1_MOUSE
θ value	8.99809 (rank : 183)	NC score	0.012724 (rank : 277)
Query Neighborhood Hits	186	Target Neighborhood Hits	678	Shared Neighborhood Hits	27
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

PKHA4_MOUSE
θ value	8.99809 (rank : 184)	NC score	0.041647 (rank : 226)
Query Neighborhood Hits	186	Target Neighborhood Hits	202	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

PSD4_HUMAN
θ value	8.99809 (rank : 185)	NC score	0.021237 (rank : 259)
Query Neighborhood Hits	186	Target Neighborhood Hits	178	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

TRI65_HUMAN
θ value	8.99809 (rank : 186)	NC score	-0.000400 (rank : 302)
Query Neighborhood Hits	186	Target Neighborhood Hits	330	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PJ69, Q4G0F0, Q6DKJ6, Q9BRP6	Gene names	TRIM65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

ABI1_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.061939 (rank : 156)
Query Neighborhood Hits	186	Target Neighborhood Hits	257	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 188)	NC score	0.068477 (rank : 134)
Query Neighborhood Hits	186	Target Neighborhood Hits	246	Shared Neighborhood Hits	47
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.077092 (rank : 116)
Query Neighborhood Hits	186	Target Neighborhood Hits	350	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 190)	NC score	0.078495 (rank : 111)
Query Neighborhood Hits	186	Target Neighborhood Hits	266	Shared Neighborhood Hits	50
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.050407 (rank : 216)
Query Neighborhood Hits	186	Target Neighborhood Hits	227	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AHI1_HUMAN
θ value	θ > 10 (rank : 192)	NC score	0.062825 (rank : 148)
Query Neighborhood Hits	186	Target Neighborhood Hits	537	Shared Neighborhood Hits	47
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ARFG1_HUMAN
θ value	θ > 10 (rank : 193)	NC score	0.051462 (rank : 211)
Query Neighborhood Hits	186	Target Neighborhood Hits	60	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N6T3, Q96KC4, Q96T02, Q9NSU3, Q9NVF6, Q9UIL0	Gene names	ARFGAP1, ARF1GAP
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

ARFG1_MOUSE
θ value	θ > 10 (rank : 194)	NC score	0.055485 (rank : 189)
Query Neighborhood Hits	186	Target Neighborhood Hits	51	Shared Neighborhood Hits	8
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

ARFG3_HUMAN
θ value	θ > 10 (rank : 195)	NC score	0.057941 (rank : 178)
Query Neighborhood Hits	186	Target Neighborhood Hits	56	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ARFG3_MOUSE
θ value	θ > 10 (rank : 196)	NC score	0.058340 (rank : 175)
Query Neighborhood Hits	186	Target Neighborhood Hits	80	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D8S3, Q99KN8	Gene names	Arfgap3
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ARHG6_HUMAN
θ value	θ > 10 (rank : 197)	NC score	0.055915 (rank : 186)
Query Neighborhood Hits	186	Target Neighborhood Hits	376	Shared Neighborhood Hits	47
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	θ > 10 (rank : 198)	NC score	0.058395 (rank : 174)
Query Neighborhood Hits	186	Target Neighborhood Hits	394	Shared Neighborhood Hits	45
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG7_HUMAN
θ value	θ > 10 (rank : 199)	NC score	0.066310 (rank : 137)
Query Neighborhood Hits	186	Target Neighborhood Hits	347	Shared Neighborhood Hits	49
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG9_HUMAN
θ value	θ > 10 (rank : 200)	NC score	0.062777 (rank : 149)
Query Neighborhood Hits	186	Target Neighborhood Hits	235	Shared Neighborhood Hits	42
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 201)	NC score	0.062672 (rank : 150)
Query Neighborhood Hits	186	Target Neighborhood Hits	234	Shared Neighborhood Hits	41
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ATCAY_HUMAN
θ value	θ > 10 (rank : 202)	NC score	0.058335 (rank : 176)
Query Neighborhood Hits	186	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q86WG3, Q8NAQ2, Q8TAQ3, Q96HC6, Q96JF5	Gene names	ATCAY, KIAA1872
Domain Architecture
Description	Caytaxin (Ataxia Cayman type protein) (BNIP-H).

ATCAY_MOUSE
θ value	θ > 10 (rank : 203)	NC score	0.058871 (rank : 169)
Query Neighborhood Hits	186	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BHE3, Q3TR94	Gene names	Atcay
Domain Architecture
Description	Caytaxin.

BCAR1_MOUSE
θ value	θ > 10 (rank : 204)	NC score	0.051045 (rank : 212)
Query Neighborhood Hits	186	Target Neighborhood Hits	438	Shared Neighborhood Hits	58
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BNIP2_HUMAN
θ value	θ > 10 (rank : 205)	NC score	0.061912 (rank : 157)
Query Neighborhood Hits	186	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q12982	Gene names	BNIP2, NIP2
Domain Architecture
Description	BCL2/adenovirus E1B 19 kDa protein-interacting protein 2.

BNIP2_MOUSE
θ value	θ > 10 (rank : 206)	NC score	0.061778 (rank : 159)
Query Neighborhood Hits	186	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	O54940	Gene names	Bnip2, Nip2l
Domain Architecture
Description	BCL2/adenovirus E1B 19 kDa protein-interacting protein 2.

BNIPL_HUMAN
θ value	θ > 10 (rank : 207)	NC score	0.057643 (rank : 180)
Query Neighborhood Hits	186	Target Neighborhood Hits	40	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z465, Q6DK43, Q8TCY7, Q8WYG2	Gene names	BNIPL
Domain Architecture	No domain graphic available
Description	Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein.

BNIPL_MOUSE
θ value	θ > 10 (rank : 208)	NC score	0.057161 (rank : 182)
Query Neighborhood Hits	186	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q99JU7, Q923E3	Gene names	Bnipl
Domain Architecture	No domain graphic available
Description	Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein.

CD2AP_HUMAN
θ value	θ > 10 (rank : 209)	NC score	0.084984 (rank : 98)
Query Neighborhood Hits	186	Target Neighborhood Hits	315	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CD2AP_MOUSE
θ value	θ > 10 (rank : 210)	NC score	0.076918 (rank : 117)
Query Neighborhood Hits	186	Target Neighborhood Hits	336	Shared Neighborhood Hits	49
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

CENA1_HUMAN
θ value	θ > 10 (rank : 211)	NC score	0.061457 (rank : 161)
Query Neighborhood Hits	186	Target Neighborhood Hits	87	Shared Neighborhood Hits	10
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

CENA2_HUMAN
θ value	θ > 10 (rank : 212)	NC score	0.063770 (rank : 144)
Query Neighborhood Hits	186	Target Neighborhood Hits	83	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

CENA2_MOUSE
θ value	θ > 10 (rank : 213)	NC score	0.056169 (rank : 184)
Query Neighborhood Hits	186	Target Neighborhood Hits	68	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

CENB1_HUMAN
θ value	θ > 10 (rank : 214)	NC score	0.089064 (rank : 91)
Query Neighborhood Hits	186	Target Neighborhood Hits	383	Shared Neighborhood Hits	19
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

CENB2_HUMAN
θ value	θ > 10 (rank : 215)	NC score	0.094475 (rank : 81)
Query Neighborhood Hits	186	Target Neighborhood Hits	425	Shared Neighborhood Hits	21
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

CENB5_HUMAN
θ value	θ > 10 (rank : 216)	NC score	0.089489 (rank : 90)
Query Neighborhood Hits	186	Target Neighborhood Hits	395	Shared Neighborhood Hits	17
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CENG1_HUMAN
θ value	θ > 10 (rank : 217)	NC score	0.055749 (rank : 188)
Query Neighborhood Hits	186	Target Neighborhood Hits	544	Shared Neighborhood Hits	18
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

CIP4_HUMAN
θ value	θ > 10 (rank : 218)	NC score	0.079599 (rank : 108)
Query Neighborhood Hits	186	Target Neighborhood Hits	374	Shared Neighborhood Hits	36
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CRK_HUMAN
θ value	θ > 10 (rank : 219)	NC score	0.074051 (rank : 125)
Query Neighborhood Hits	186	Target Neighborhood Hits	308	Shared Neighborhood Hits	51
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 220)	NC score	0.073417 (rank : 126)
Query Neighborhood Hits	186	Target Neighborhood Hits	314	Shared Neighborhood Hits	51
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

DAPP1_HUMAN
θ value	θ > 10 (rank : 221)	NC score	0.075974 (rank : 122)
Query Neighborhood Hits	186	Target Neighborhood Hits	227	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 222)	NC score	0.078193 (rank : 112)
Query Neighborhood Hits	186	Target Neighborhood Hits	225	Shared Neighborhood Hits	32
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DDEF1_MOUSE
θ value	θ > 10 (rank : 223)	NC score	0.077286 (rank : 115)
Query Neighborhood Hits	186	Target Neighborhood Hits	592	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_MOUSE
θ value	θ > 10 (rank : 224)	NC score	0.082574 (rank : 99)
Query Neighborhood Hits	186	Target Neighborhood Hits	625	Shared Neighborhood Hits	42
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDFL1_HUMAN
θ value	θ > 10 (rank : 225)	NC score	0.068673 (rank : 133)
Query Neighborhood Hits	186	Target Neighborhood Hits	353	Shared Neighborhood Hits	14
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

DDFL1_MOUSE
θ value	θ > 10 (rank : 226)	NC score	0.062855 (rank : 147)
Query Neighborhood Hits	186	Target Neighborhood Hits	324	Shared Neighborhood Hits	12
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

DNMBP_HUMAN
θ value	θ > 10 (rank : 227)	NC score	0.081927 (rank : 102)
Query Neighborhood Hits	186	Target Neighborhood Hits	413	Shared Neighborhood Hits	57
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
θ value	θ > 10 (rank : 228)	NC score	0.076316 (rank : 120)
Query Neighborhood Hits	186	Target Neighborhood Hits	435	Shared Neighborhood Hits	61
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DP13A_HUMAN
θ value	θ > 10 (rank : 229)	NC score	0.058551 (rank : 172)
Query Neighborhood Hits	186	Target Neighborhood Hits	107	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

DP13A_MOUSE
θ value	θ > 10 (rank : 230)	NC score	0.054786 (rank : 191)
Query Neighborhood Hits	186	Target Neighborhood Hits	96	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K3H0, Q3UJP7, Q69ZJ9, Q8BWZ8, Q8VCJ8, Q9CUW4	Gene names	Appl1, Dip13a, Kiaa1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

FA13A_HUMAN
θ value	θ > 10 (rank : 231)	NC score	0.057839 (rank : 179)
Query Neighborhood Hits	186	Target Neighborhood Hits	102	Shared Neighborhood Hits	2
SwissProt Accessions	O94988, Q8NBA3	Gene names	FAM13A1, KIAA0914
Domain Architecture	No domain graphic available
Description	Protein FAM13A1.

FA13A_MOUSE
θ value	θ > 10 (rank : 232)	NC score	0.058765 (rank : 170)
Query Neighborhood Hits	186	Target Neighborhood Hits	83	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BGI4, Q8BZ91	Gene names	Fam13a1, Precm1
Domain Architecture	No domain graphic available
Description	Protein FAM13A1 (Precm1 protein).

GRAP2_HUMAN
θ value	θ > 10 (rank : 233)	NC score	0.092846 (rank : 84)
Query Neighborhood Hits	186	Target Neighborhood Hits	304	Shared Neighborhood Hits	56
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

GRAP2_MOUSE
θ value	θ > 10 (rank : 234)	NC score	0.090014 (rank : 89)
Query Neighborhood Hits	186	Target Neighborhood Hits	297	Shared Neighborhood Hits	56
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

GRAP_HUMAN
θ value	θ > 10 (rank : 235)	NC score	0.112312 (rank : 69)
Query Neighborhood Hits	186	Target Neighborhood Hits	307	Shared Neighborhood Hits	55
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

GRAP_MOUSE
θ value	θ > 10 (rank : 236)	NC score	0.108934 (rank : 72)
Query Neighborhood Hits	186	Target Neighborhood Hits	309	Shared Neighborhood Hits	55
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	θ > 10 (rank : 237)	NC score	0.106211 (rank : 73)
Query Neighborhood Hits	186	Target Neighborhood Hits	310	Shared Neighborhood Hits	55
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 238)	NC score	0.106020 (rank : 74)
Query Neighborhood Hits	186	Target Neighborhood Hits	312	Shared Neighborhood Hits	55
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

GRP3_HUMAN
θ value	θ > 10 (rank : 239)	NC score	0.086993 (rank : 96)
Query Neighborhood Hits	186	Target Neighborhood Hits	131	Shared Neighborhood Hits	10
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

HCLS1_HUMAN
θ value	θ > 10 (rank : 240)	NC score	0.078578 (rank : 110)
Query Neighborhood Hits	186	Target Neighborhood Hits	358	Shared Neighborhood Hits	53
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 241)	NC score	0.077413 (rank : 114)
Query Neighborhood Hits	186	Target Neighborhood Hits	329	Shared Neighborhood Hits	51
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

MYO1E_HUMAN
θ value	θ > 10 (rank : 242)	NC score	0.051844 (rank : 209)
Query Neighborhood Hits	186	Target Neighborhood Hits	293	Shared Neighborhood Hits	46
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

MYO1F_HUMAN
θ value	θ > 10 (rank : 243)	NC score	0.053247 (rank : 201)
Query Neighborhood Hits	186	Target Neighborhood Hits	275	Shared Neighborhood Hits	44
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
θ value	θ > 10 (rank : 244)	NC score	0.053303 (rank : 199)
Query Neighborhood Hits	186	Target Neighborhood Hits	262	Shared Neighborhood Hits	44
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

NCF1_MOUSE
θ value	θ > 10 (rank : 245)	NC score	0.064492 (rank : 140)
Query Neighborhood Hits	186	Target Neighborhood Hits	198	Shared Neighborhood Hits	42
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NCF4_HUMAN
θ value	θ > 10 (rank : 246)	NC score	0.076006 (rank : 121)
Query Neighborhood Hits	186	Target Neighborhood Hits	161	Shared Neighborhood Hits	35
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.096808 (rank : 78)
Query Neighborhood Hits	186	Target Neighborhood Hits	312	Shared Neighborhood Hits	52
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.118362 (rank : 65)
Query Neighborhood Hits	186	Target Neighborhood Hits	310	Shared Neighborhood Hits	53
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NPHP1_HUMAN
θ value	θ > 10 (rank : 249)	NC score	0.070075 (rank : 132)
Query Neighborhood Hits	186	Target Neighborhood Hits	288	Shared Neighborhood Hits	42
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 250)	NC score	0.072843 (rank : 128)
Query Neighborhood Hits	186	Target Neighborhood Hits	267	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OSTF1_HUMAN
θ value	θ > 10 (rank : 251)	NC score	0.062405 (rank : 153)
Query Neighborhood Hits	186	Target Neighborhood Hits	466	Shared Neighborhood Hits	47
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 252)	NC score	0.058900 (rank : 168)
Query Neighborhood Hits	186	Target Neighborhood Hits	467	Shared Neighborhood Hits	47
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

P55G_HUMAN
θ value	θ > 10 (rank : 253)	NC score	0.094718 (rank : 80)
Query Neighborhood Hits	186	Target Neighborhood Hits	451	Shared Neighborhood Hits	29
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 254)	NC score	0.093204 (rank : 83)
Query Neighborhood Hits	186	Target Neighborhood Hits	401	Shared Neighborhood Hits	28
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

PACN1_HUMAN
θ value	θ > 10 (rank : 255)	NC score	0.052779 (rank : 204)
Query Neighborhood Hits	186	Target Neighborhood Hits	320	Shared Neighborhood Hits	47
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 256)	NC score	0.053646 (rank : 197)
Query Neighborhood Hits	186	Target Neighborhood Hits	283	Shared Neighborhood Hits	47
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 257)	NC score	0.054118 (rank : 196)
Query Neighborhood Hits	186	Target Neighborhood Hits	339	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 258)	NC score	0.050873 (rank : 213)
Query Neighborhood Hits	186	Target Neighborhood Hits	382	Shared Neighborhood Hits	50
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PCTL_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.054161 (rank : 195)
Query Neighborhood Hits	186	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y365, O60532	Gene names	STARD10, SDCCAG28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28) (Antigen NY-CO-28).

PCTL_MOUSE
θ value	θ > 10 (rank : 260)	NC score	0.054782 (rank : 192)
Query Neighborhood Hits	186	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JMD3	Gene names	Stard10, Pctpl, Sdccag28, Sdccagg28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28 homolog).

PDZD8_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.061260 (rank : 163)
Query Neighborhood Hits	186	Target Neighborhood Hits	185	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

PKHA1_HUMAN
θ value	θ > 10 (rank : 262)	NC score	0.067600 (rank : 135)
Query Neighborhood Hits	186	Target Neighborhood Hits	127	Shared Neighborhood Hits	22
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PKHA1_MOUSE
θ value	θ > 10 (rank : 263)	NC score	0.057180 (rank : 181)
Query Neighborhood Hits	186	Target Neighborhood Hits	120	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

PLCG1_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.052820 (rank : 203)
Query Neighborhood Hits	186	Target Neighborhood Hits	293	Shared Neighborhood Hits	52
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.053361 (rank : 198)
Query Neighborhood Hits	186	Target Neighborhood Hits	314	Shared Neighborhood Hits	52
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.054291 (rank : 194)
Query Neighborhood Hits	186	Target Neighborhood Hits	280	Shared Neighborhood Hits	45
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PLEK2_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.052676 (rank : 205)
Query Neighborhood Hits	186	Target Neighborhood Hits	96	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

PPIP1_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.076642 (rank : 118)
Query Neighborhood Hits	186	Target Neighborhood Hits	389	Shared Neighborhood Hits	53
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.070302 (rank : 131)
Query Neighborhood Hits	186	Target Neighborhood Hits	377	Shared Neighborhood Hits	51
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PRP40_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.053265 (rank : 200)
Query Neighborhood Hits	186	Target Neighborhood Hits	442	Shared Neighborhood Hits	25
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

PRP40_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.050534 (rank : 215)
Query Neighborhood Hits	186	Target Neighborhood Hits	447	Shared Neighborhood Hits	24
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

RASA1_HUMAN
θ value	θ > 10 (rank : 272)	NC score	0.054630 (rank : 193)
Query Neighborhood Hits	186	Target Neighborhood Hits	258	Shared Neighborhood Hits	32
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

SH21A_HUMAN
θ value	θ > 10 (rank : 273)	NC score	0.051552 (rank : 210)
Query Neighborhood Hits	186	Target Neighborhood Hits	89	Shared Neighborhood Hits	15
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 274)	NC score	0.050740 (rank : 214)
Query Neighborhood Hits	186	Target Neighborhood Hits	89	Shared Neighborhood Hits	15
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH3G1_HUMAN
θ value	θ > 10 (rank : 275)	NC score	0.052997 (rank : 202)
Query Neighborhood Hits	186	Target Neighborhood Hits	307	Shared Neighborhood Hits	39
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G2_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.055803 (rank : 187)
Query Neighborhood Hits	186	Target Neighborhood Hits	324	Shared Neighborhood Hits	44
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.056188 (rank : 183)
Query Neighborhood Hits	186	Target Neighborhood Hits	319	Shared Neighborhood Hits	42
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3K1_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.079545 (rank : 109)
Query Neighborhood Hits	186	Target Neighborhood Hits	341	Shared Neighborhood Hits	50
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.082193 (rank : 100)
Query Neighborhood Hits	186	Target Neighborhood Hits	332	Shared Neighborhood Hits	50
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SLAP1_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.061803 (rank : 158)
Query Neighborhood Hits	186	Target Neighborhood Hits	113	Shared Neighborhood Hits	22
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 281)	NC score	0.065599 (rank : 138)
Query Neighborhood Hits	186	Target Neighborhood Hits	117	Shared Neighborhood Hits	22
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.056120 (rank : 185)
Query Neighborhood Hits	186	Target Neighborhood Hits	139	Shared Neighborhood Hits	28
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 283)	NC score	0.064516 (rank : 139)
Query Neighborhood Hits	186	Target Neighborhood Hits	136	Shared Neighborhood Hits	29
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SMAP1_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.062858 (rank : 146)
Query Neighborhood Hits	186	Target Neighborhood Hits	98	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IYB5, Q53H70, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4	Gene names	SMAP1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMAP1_MOUSE
θ value	θ > 10 (rank : 285)	NC score	0.062634 (rank : 151)
Query Neighborhood Hits	186	Target Neighborhood Hits	120	Shared Neighborhood Hits	11
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

SMP1L_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.064135 (rank : 142)
Query Neighborhood Hits	186	Target Neighborhood Hits	74	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

SMP1L_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.063954 (rank : 143)
Query Neighborhood Hits	186	Target Neighborhood Hits	70	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

SPTA1_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.073417 (rank : 127)
Query Neighborhood Hits	186	Target Neighborhood Hits	748	Shared Neighborhood Hits	52
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SRC8_HUMAN
θ value	θ > 10 (rank : 289)	NC score	0.060785 (rank : 164)
Query Neighborhood Hits	186	Target Neighborhood Hits	269	Shared Neighborhood Hits	46
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 290)	NC score	0.062398 (rank : 154)
Query Neighborhood Hits	186	Target Neighborhood Hits	292	Shared Neighborhood Hits	45
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

STAC3_HUMAN
θ value	θ > 10 (rank : 291)	NC score	0.093301 (rank : 82)
Query Neighborhood Hits	186	Target Neighborhood Hits	228	Shared Neighborhood Hits	50
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 292)	NC score	0.095845 (rank : 79)
Query Neighborhood Hits	186	Target Neighborhood Hits	232	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 293)	NC score	0.082115 (rank : 101)
Query Neighborhood Hits	186	Target Neighborhood Hits	276	Shared Neighborhood Hits	49
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 294)	NC score	0.087448 (rank : 94)
Query Neighborhood Hits	186	Target Neighborhood Hits	268	Shared Neighborhood Hits	50
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAM1_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.058320 (rank : 177)
Query Neighborhood Hits	186	Target Neighborhood Hits	271	Shared Neighborhood Hits	47
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 296)	NC score	0.058413 (rank : 173)
Query Neighborhood Hits	186	Target Neighborhood Hits	273	Shared Neighborhood Hits	45
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 297)	NC score	0.059692 (rank : 165)
Query Neighborhood Hits	186	Target Neighborhood Hits	288	Shared Neighborhood Hits	46
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 298)	NC score	0.062469 (rank : 152)
Query Neighborhood Hits	186	Target Neighborhood Hits	285	Shared Neighborhood Hits	49
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

UN13A_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.058597 (rank : 171)
Query Neighborhood Hits	186	Target Neighborhood Hits	285	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

UN13B_HUMAN
θ value	θ > 10 (rank : 300)	NC score	0.058956 (rank : 167)
Query Neighborhood Hits	186	Target Neighborhood Hits	217	Shared Neighborhood Hits	22
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

UN13B_MOUSE
θ value	θ > 10 (rank : 301)	NC score	0.055403 (rank : 190)
Query Neighborhood Hits	186	Target Neighborhood Hits	210	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

VAV2_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.081303 (rank : 105)
Query Neighborhood Hits	186	Target Neighborhood Hits	453	Shared Neighborhood Hits	52
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	θ > 10 (rank : 303)	NC score	0.081141 (rank : 106)
Query Neighborhood Hits	186	Target Neighborhood Hits	456	Shared Neighborhood Hits	52
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV3_HUMAN
θ value	θ > 10 (rank : 304)	NC score	0.092682 (rank : 85)
Query Neighborhood Hits	186	Target Neighborhood Hits	398	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	θ > 10 (rank : 305)	NC score	0.091802 (rank : 86)
Query Neighborhood Hits	186	Target Neighborhood Hits	404	Shared Neighborhood Hits	53
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

VAV_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.071543 (rank : 130)
Query Neighborhood Hits	186	Target Neighborhood Hits	452	Shared Neighborhood Hits	54
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	θ > 10 (rank : 307)	NC score	0.074080 (rank : 124)
Query Neighborhood Hits	186	Target Neighborhood Hits	430	Shared Neighborhood Hits	55
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

Hits sorted by NC score

RHG09_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	186	Target Neighborhood Hits	186	Shared Neighborhood Hits	186
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

RHG12_HUMAN
NC score	0.933039 (rank : 2)	θ value	1.65806e-78 (rank : 2)
Query Neighborhood Hits	186	Target Neighborhood Hits	190	Shared Neighborhood Hits	102
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
NC score	0.930371 (rank : 3)	θ value	1.65806e-78 (rank : 3)
Query Neighborhood Hits	186	Target Neighborhood Hits	204	Shared Neighborhood Hits	104
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

GMIP_MOUSE
NC score	0.834526 (rank : 4)	θ value	2.97466e-19 (rank : 17)
Query Neighborhood Hits	186	Target Neighborhood Hits	202	Shared Neighborhood Hits	71
SwissProt Accessions	Q6PGG2, Q6P9S3	Gene names	Gmip
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

GMIP_HUMAN
NC score	0.827561 (rank : 5)	θ value	1.92812e-18 (rank : 19)
Query Neighborhood Hits	186	Target Neighborhood Hits	225	Shared Neighborhood Hits	67
SwissProt Accessions	Q9P107	Gene names	GMIP
Domain Architecture	No domain graphic available
Description	GEM-interacting protein (GMIP).

GRLF1_HUMAN
NC score	0.818477 (rank : 6)	θ value	8.36355e-22 (rank : 13)
Query Neighborhood Hits	186	Target Neighborhood Hits	167	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NRY4, Q14452, Q9C0E1	Gene names	GRLF1, GRF1, KIAA1722
Domain Architecture
Description	Glucocorticoid receptor DNA-binding factor 1 (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A).

3BP1_MOUSE
NC score	0.816716 (rank : 7)	θ value	1.80466e-16 (rank : 25)
Query Neighborhood Hits	186	Target Neighborhood Hits	238	Shared Neighborhood Hits	70
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

CHIO_MOUSE
NC score	0.815601 (rank : 8)	θ value	3.87602e-27 (rank : 6)
Query Neighborhood Hits	186	Target Neighborhood Hits	130	Shared Neighborhood Hits	62
SwissProt Accessions	Q80XD1, Q9D9W2, Q9ER57	Gene names	Chn2, Arhgap3, Bch
Domain Architecture	No domain graphic available
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

RGAP1_HUMAN
NC score	0.814131 (rank : 9)	θ value	1.52774e-15 (rank : 30)
Query Neighborhood Hits	186	Target Neighborhood Hits	189	Shared Neighborhood Hits	64
SwissProt Accessions	Q9H0H5, Q6PJ26, Q9NWN2, Q9P250, Q9P2W2	Gene names	RACGAP1, KIAA1478, MGCRACGAP
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

TCGAP_MOUSE
NC score	0.812694 (rank : 10)	θ value	1.24688e-25 (rank : 10)
Query Neighborhood Hits	186	Target Neighborhood Hits	409	Shared Neighborhood Hits	89
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

RGAP1_MOUSE
NC score	0.811033 (rank : 11)	θ value	9.26847e-13 (rank : 40)
Query Neighborhood Hits	186	Target Neighborhood Hits	185	Shared Neighborhood Hits	67
SwissProt Accessions	Q9WVM1, Q3THR5, Q3TI41, Q3TM81	Gene names	Racgap1, Mgcracgap
Domain Architecture	No domain graphic available
Description	Rac GTPase-activating protein 1 (MgcRacGAP).

OPHN1_HUMAN
NC score	0.807734 (rank : 12)	θ value	8.36355e-22 (rank : 14)
Query Neighborhood Hits	186	Target Neighborhood Hits	161	Shared Neighborhood Hits	65
SwissProt Accessions	O60890, Q5JQ81, Q8WX47	Gene names	OPHN1
Domain Architecture
Description	Oligophrenin 1.

OPHN1_MOUSE
NC score	0.806950 (rank : 13)	θ value	3.75424e-22 (rank : 11)
Query Neighborhood Hits	186	Target Neighborhood Hits	174	Shared Neighborhood Hits	63
SwissProt Accessions	Q99J31, Q544K7	Gene names	Ophn1
Domain Architecture
Description	Oligophrenin 1.

3BP1_HUMAN
NC score	0.802626 (rank : 14)	θ value	9.56915e-18 (rank : 20)
Query Neighborhood Hits	186	Target Neighborhood Hits	376	Shared Neighborhood Hits	77
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

RHG01_HUMAN
NC score	0.792516 (rank : 15)	θ value	2.97466e-19 (rank : 18)
Query Neighborhood Hits	186	Target Neighborhood Hits	75	Shared Neighborhood Hits	62
SwissProt Accessions	Q07960	Gene names	ARHGAP1, CDC42GAP, RHOGAP1
Domain Architecture
Description	Rho-GTPase-activating protein 1 (GTPase-activating protein rhoOGAP) (Rho-related small GTPase protein activator) (CDC42 GTPase-activating protein) (p50-RhoGAP).

RHG06_HUMAN
NC score	0.789746 (rank : 16)	θ value	3.89403e-11 (rank : 46)
Query Neighborhood Hits	186	Target Neighborhood Hits	114	Shared Neighborhood Hits	62
SwissProt Accessions	O43182, O43437, Q9P1B3, Q9UK81, Q9UK82	Gene names	ARHGAP6, RHOGAP6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

CHIN_MOUSE
NC score	0.787705 (rank : 17)	θ value	1.02001e-27 (rank : 4)
Query Neighborhood Hits	186	Target Neighborhood Hits	229	Shared Neighborhood Hits	75
SwissProt Accessions	Q91V57, Q3UGY3, Q7TQE5, Q8BWU6, Q9D9B3	Gene names	Chn1, Arhgap2
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

RHG06_MOUSE
NC score	0.787302 (rank : 18)	θ value	5.08577e-11 (rank : 47)
Query Neighborhood Hits	186	Target Neighborhood Hits	105	Shared Neighborhood Hits	62
SwissProt Accessions	O54834, Q9QZL8	Gene names	Arhgap6
Domain Architecture
Description	Rho-GTPase-activating protein 6 (Rho-type GTPase-activating protein RhoGAPX-1).

CHIO_HUMAN
NC score	0.786231 (rank : 19)	θ value	6.61148e-27 (rank : 7)
Query Neighborhood Hits	186	Target Neighborhood Hits	220	Shared Neighborhood Hits	72
SwissProt Accessions	P52757, Q75MM2	Gene names	CHN2, ARHGAP3, BCH
Domain Architecture
Description	Beta-chimaerin (Beta-chimerin) (Rho-GTPase-activating protein 3).

CHIN_HUMAN
NC score	0.785585 (rank : 20)	θ value	2.96777e-27 (rank : 5)
Query Neighborhood Hits	186	Target Neighborhood Hits	227	Shared Neighborhood Hits	72
SwissProt Accessions	P15882, Q53SD6, Q53SH5, Q96FB0	Gene names	CHN1, ARHGAP2, CHN
Domain Architecture
Description	N-chimaerin (NC) (N-chimerin) (Alpha chimerin) (A-chimaerin) (Rho- GTPase-activating protein 2).

RHG05_MOUSE
NC score	0.783223 (rank : 21)	θ value	9.56915e-18 (rank : 21)
Query Neighborhood Hits	186	Target Neighborhood Hits	165	Shared Neighborhood Hits	66
SwissProt Accessions	P97393	Gene names	Arhgap5, Rhogap5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG18_HUMAN
NC score	0.779803 (rank : 22)	θ value	2.28291e-11 (rank : 44)
Query Neighborhood Hits	186	Target Neighborhood Hits	90	Shared Neighborhood Hits	60
SwissProt Accessions	Q8N392, Q58EZ3, Q6P679, Q6PJD7, Q96S64	Gene names	ARHGAP18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18 (MacGAP).

RHG05_HUMAN
NC score	0.774564 (rank : 23)	θ value	1.058e-16 (rank : 23)
Query Neighborhood Hits	186	Target Neighborhood Hits	158	Shared Neighborhood Hits	64
SwissProt Accessions	Q13017	Gene names	ARHGAP5, RHOGAP5
Domain Architecture
Description	Rho-GTPase-activating protein 5 (p190-B).

RHG08_MOUSE
NC score	0.774057 (rank : 24)	θ value	1.29331e-14 (rank : 36)
Query Neighborhood Hits	186	Target Neighborhood Hits	73	Shared Neighborhood Hits	62
SwissProt Accessions	Q9CXP4, Q99JY7	Gene names	Arhgap8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

RHG08_HUMAN
NC score	0.773962 (rank : 25)	θ value	1.16975e-15 (rank : 29)
Query Neighborhood Hits	186	Target Neighborhood Hits	88	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NSG0, O75983, O95695, Q96RW1, Q96RW2, Q9HA49, Q9HC46, Q9NVX8, Q9NXL1, Q9UH20	Gene names	ARHGAP8
Domain Architecture
Description	Rho-GTPase-activating protein 8.

RHG18_MOUSE
NC score	0.772393 (rank : 26)	θ value	4.16044e-13 (rank : 39)
Query Neighborhood Hits	186	Target Neighborhood Hits	110	Shared Neighborhood Hits	61
SwissProt Accessions	Q8K0Q5, Q8BP03, Q8R196	Gene names	Arhgap18
Domain Architecture	No domain graphic available
Description	Rho-GTPase-activating protein 18.

RHG26_HUMAN
NC score	0.769929 (rank : 27)	θ value	4.9032e-22 (rank : 12)
Query Neighborhood Hits	186	Target Neighborhood Hits	281	Shared Neighborhood Hits	88
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

ABR_HUMAN
NC score	0.768006 (rank : 28)	θ value	1.24688e-25 (rank : 9)
Query Neighborhood Hits	186	Target Neighborhood Hits	166	Shared Neighborhood Hits	71
SwissProt Accessions	Q12979, Q13693, Q13694	Gene names	ABR
Domain Architecture
Description	Active breakpoint cluster region-related protein.

RHG04_HUMAN
NC score	0.760478 (rank : 29)	θ value	3.17815e-21 (rank : 15)
Query Neighborhood Hits	186	Target Neighborhood Hits	307	Shared Neighborhood Hits	98
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

BCR_HUMAN
NC score	0.752034 (rank : 30)	θ value	1.33526e-19 (rank : 16)
Query Neighborhood Hits	186	Target Neighborhood Hits	204	Shared Neighborhood Hits	71
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

SRGP2_HUMAN
NC score	0.740832 (rank : 31)	θ value	4.74913e-17 (rank : 22)
Query Neighborhood Hits	186	Target Neighborhood Hits	331	Shared Neighborhood Hits	98
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
NC score	0.732884 (rank : 32)	θ value	6.85773e-16 (rank : 27)
Query Neighborhood Hits	186	Target Neighborhood Hits	324	Shared Neighborhood Hits	100
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

RBP1_MOUSE
NC score	0.730551 (rank : 33)	θ value	8.95645e-16 (rank : 28)
Query Neighborhood Hits	186	Target Neighborhood Hits	493	Shared Neighborhood Hits	65
SwissProt Accessions	Q62172, Q9CRE5	Gene names	Ralbp1, Rip1
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

SRGP1_HUMAN
NC score	0.727598 (rank : 34)	θ value	2.20605e-14 (rank : 37)
Query Neighborhood Hits	186	Target Neighborhood Hits	390	Shared Neighborhood Hits	99
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

TCGAP_HUMAN
NC score	0.723695 (rank : 35)	θ value	9.54697e-26 (rank : 8)
Query Neighborhood Hits	186	Target Neighborhood Hits	872	Shared Neighborhood Hits	103
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

FNBP2_HUMAN
NC score	0.722695 (rank : 36)	θ value	5.8054e-15 (rank : 34)
Query Neighborhood Hits	186	Target Neighborhood Hits	432	Shared Neighborhood Hits	102
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

RHG25_MOUSE
NC score	0.722564 (rank : 37)	θ value	7.84624e-12 (rank : 42)
Query Neighborhood Hits	186	Target Neighborhood Hits	492	Shared Neighborhood Hits	76
SwissProt Accessions	Q8BYW1, Q2VPR2, Q3TE04, Q3TVX0, Q3UVB7, Q6A0E0, Q8BX98	Gene names	Arhgap25, Kiaa0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

RBP1_HUMAN
NC score	0.713109 (rank : 38)	θ value	3.40345e-15 (rank : 32)
Query Neighborhood Hits	186	Target Neighborhood Hits	521	Shared Neighborhood Hits	65
SwissProt Accessions	Q15311	Gene names	RALBP1, RLIP1, RLIP76
Domain Architecture
Description	RalA-binding protein 1 (RalBP1) (Ral-interacting protein 1) (76 kDa Ral-interacting protein) (Dinitrophenyl S-glutathione ATPase) (DNP-SG ATPase).

RHG25_HUMAN
NC score	0.694114 (rank : 39)	θ value	2.98157e-11 (rank : 45)
Query Neighborhood Hits	186	Target Neighborhood Hits	550	Shared Neighborhood Hits	70
SwissProt Accessions	P42331, Q8IXQ2	Gene names	ARHGAP25, KIAA0053
Domain Architecture
Description	Rho-GTPase-activating protein 25.

TAGAP_HUMAN
NC score	0.683138 (rank : 40)	θ value	1.69304e-06 (rank : 57)
Query Neighborhood Hits	186	Target Neighborhood Hits	82	Shared Neighborhood Hits	61
SwissProt Accessions	Q8N103, Q2NKM8, Q8NI40, Q96KZ2, Q96QA2	Gene names	TAGAP, TAGAP1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

TAGAP_MOUSE
NC score	0.678193 (rank : 41)	θ value	0.00102713 (rank : 61)
Query Neighborhood Hits	186	Target Neighborhood Hits	83	Shared Neighborhood Hits	60
SwissProt Accessions	Q8K2L9, Q920D6	Gene names	Tagap, Tagap1
Domain Architecture	No domain graphic available
Description	T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein).

RHG07_MOUSE
NC score	0.672739 (rank : 42)	θ value	1.9326e-10 (rank : 49)
Query Neighborhood Hits	186	Target Neighborhood Hits	103	Shared Neighborhood Hits	62
SwissProt Accessions	Q9R0Z9, Q8R541	Gene names	Dlc1, Arhgap7, Stard12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein homolog) (Dlc-1) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

RHG07_HUMAN
NC score	0.668797 (rank : 43)	θ value	7.84624e-12 (rank : 41)
Query Neighborhood Hits	186	Target Neighborhood Hits	108	Shared Neighborhood Hits	62
SwissProt Accessions	Q96QB1, O14868, O43199, Q9C0E0	Gene names	DLC1, ARHGAP7, KIAA1723, STARD12
Domain Architecture
Description	Rho-GTPase-activating protein 7 (Rho-type GTPase-activating protein 7) (Deleted in liver cancer 1 protein) (Dlc-1) (HP protein) (StAR-related lipid transfer protein 12) (StARD12) (START domain-containing protein 12).

CEND2_HUMAN
NC score	0.660060 (rank : 44)	θ value	7.58209e-15 (rank : 35)
Query Neighborhood Hits	186	Target Neighborhood Hits	166	Shared Neighborhood Hits	65
SwissProt Accessions	Q96P48, O94879, Q59FI7, Q6PHS3, Q8WU51, Q96HP6, Q96L71	Gene names	CENTD2, ARAP1, KIAA0782
Domain Architecture
Description	Centaurin-delta 2 (Cnt-d2) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 1).

CE005_HUMAN
NC score	0.633761 (rank : 45)	θ value	2.79066e-09 (rank : 51)
Query Neighborhood Hits	186	Target Neighborhood Hits	213	Shared Neighborhood Hits	61
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

CE005_MOUSE
NC score	0.630741 (rank : 46)	θ value	4.76016e-09 (rank : 52)
Query Neighborhood Hits	186	Target Neighborhood Hits	238	Shared Neighborhood Hits	62
SwissProt Accessions	Q8K2H3	Gene names
Domain Architecture
Description	Protein C5orf5 homolog.

CEND3_MOUSE
NC score	0.627304 (rank : 47)	θ value	5.8054e-15 (rank : 33)
Query Neighborhood Hits	186	Target Neighborhood Hits	228	Shared Neighborhood Hits	68
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

STAR8_MOUSE
NC score	0.621074 (rank : 48)	θ value	3.41135e-07 (rank : 53)
Query Neighborhood Hits	186	Target Neighborhood Hits	101	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K031, Q3UZC7, Q6A0A8, Q6P5E0, Q8R3X8	Gene names	Stard8, Kiaa0189
Domain Architecture	No domain graphic available
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

STA13_HUMAN
NC score	0.620046 (rank : 49)	θ value	7.59969e-07 (rank : 54)
Query Neighborhood Hits	186	Target Neighborhood Hits	89	Shared Neighborhood Hits	59
SwissProt Accessions	Q9Y3M8, Q5HYH1, Q5TAE3, Q6UN61, Q86TP6, Q86WQ3, Q86XT1	Gene names	STARD13, DLC2, GT650
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13) (46H23.2) (Deleted in liver cancer protein 2) (Rho GTPase-activating protein).

CEND3_HUMAN
NC score	0.617545 (rank : 50)	θ value	1.99529e-15 (rank : 31)
Query Neighborhood Hits	186	Target Neighborhood Hits	275	Shared Neighborhood Hits	67
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

STAR8_HUMAN
NC score	0.614330 (rank : 51)	θ value	1.29631e-06 (rank : 56)
Query Neighborhood Hits	186	Target Neighborhood Hits	216	Shared Neighborhood Hits	73
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

STA13_MOUSE
NC score	0.610885 (rank : 52)	θ value	7.59969e-07 (rank : 55)
Query Neighborhood Hits	186	Target Neighborhood Hits	89	Shared Neighborhood Hits	59
SwissProt Accessions	Q923Q2, Q8K369	Gene names	Stard13
Domain Architecture
Description	StAR-related lipid transfer protein 13 (StARD13) (START domain- containing protein 13).

CEND1_MOUSE
NC score	0.574390 (rank : 53)	θ value	1.86753e-13 (rank : 38)
Query Neighborhood Hits	186	Target Neighborhood Hits	260	Shared Neighborhood Hits	62
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

CEND1_HUMAN
NC score	0.550614 (rank : 54)	θ value	2.28291e-11 (rank : 43)
Query Neighborhood Hits	186	Target Neighborhood Hits	284	Shared Neighborhood Hits	63
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

K1688_MOUSE
NC score	0.536518 (rank : 55)	θ value	0.000461057 (rank : 60)
Query Neighborhood Hits	186	Target Neighborhood Hits	188	Shared Neighborhood Hits	68
SwissProt Accessions	P59281, Q69ZD4, Q6P9R6	Gene names	Kiaa1688, D15Wsu169e
Domain Architecture	No domain graphic available
Description	Protein KIAA1688.

K1688_HUMAN
NC score	0.524534 (rank : 56)	θ value	0.000158464 (rank : 58)
Query Neighborhood Hits	186	Target Neighborhood Hits	217	Shared Neighborhood Hits	67
SwissProt Accessions	Q9C0H5	Gene names	KIAA1688
Domain Architecture
Description	Protein KIAA1688.

P85A_HUMAN
NC score	0.442862 (rank : 57)	θ value	1.133e-10 (rank : 48)
Query Neighborhood Hits	186	Target Neighborhood Hits	479	Shared Neighborhood Hits	85
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
NC score	0.436928 (rank : 58)	θ value	1.25267e-09 (rank : 50)
Query Neighborhood Hits	186	Target Neighborhood Hits	435	Shared Neighborhood Hits	86
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

MYO9B_MOUSE
NC score	0.427446 (rank : 59)	θ value	1.38178e-16 (rank : 24)
Query Neighborhood Hits	186	Target Neighborhood Hits	311	Shared Neighborhood Hits	69
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

MYO9B_HUMAN
NC score	0.422442 (rank : 60)	θ value	2.35696e-16 (rank : 26)
Query Neighborhood Hits	186	Target Neighborhood Hits	641	Shared Neighborhood Hits	81
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

I5P2_HUMAN
NC score	0.340595 (rank : 61)	θ value	0.00869519 (rank : 66)
Query Neighborhood Hits	186	Target Neighborhood Hits	86	Shared Neighborhood Hits	52
SwissProt Accessions	P32019, Q5VSG9, Q5VSH0, Q5VSH1, Q658Q5, Q6P6D4, Q6PD53, Q86YE1	Gene names	INPP5B
Domain Architecture	No domain graphic available
Description	Type II inositol-1,4,5-trisphosphate 5-phosphatase precursor (EC 3.1.3.36) (Phosphoinositide 5-phosphatase) (5PTase) (75 kDa inositol polyphosphate-5-phosphatase).

OCRL_HUMAN
NC score	0.322843 (rank : 62)	θ value	0.0563607 (rank : 72)
Query Neighborhood Hits	186	Target Neighborhood Hits	77	Shared Neighborhood Hits	52
SwissProt Accessions	Q01968, O60800, Q15684, Q15774, Q5JQF1, Q5JQF2, Q9UJG5, Q9UMA5	Gene names	OCRL, INPP5F, OCRL1
Domain Architecture
Description	Inositol polyphosphate 5-phosphatase OCRL-1 (EC 3.1.3.36) (Lowe oculocerebrorenal syndrome protein).

P85B_HUMAN
NC score	0.156273 (rank : 63)	θ value	0.279714 (rank : 83)
Query Neighborhood Hits	186	Target Neighborhood Hits	543	Shared Neighborhood Hits	52
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

P85B_MOUSE
NC score	0.124102 (rank : 64)	θ value	0.813845 (rank : 102)
Query Neighborhood Hits	186	Target Neighborhood Hits	519	Shared Neighborhood Hits	49
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

NCK2_HUMAN
NC score	0.118362 (rank : 65)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	186	Target Neighborhood Hits	310	Shared Neighborhood Hits	53
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

VINEX_MOUSE
NC score	0.115280 (rank : 66)	θ value	1.81305 (rank : 127)
Query Neighborhood Hits	186	Target Neighborhood Hits	286	Shared Neighborhood Hits	53
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

SRBS1_HUMAN
NC score	0.114979 (rank : 67)	θ value	0.365318 (rank : 87)
Query Neighborhood Hits	186	Target Neighborhood Hits	396	Shared Neighborhood Hits	57
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
NC score	0.113390 (rank : 68)	θ value	0.0563607 (rank : 73)
Query Neighborhood Hits	186	Target Neighborhood Hits	409	Shared Neighborhood Hits	55
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

GRAP_HUMAN
NC score	0.112312 (rank : 69)	θ value	θ > 10 (rank : 235)
Query Neighborhood Hits	186	Target Neighborhood Hits	307	Shared Neighborhood Hits	55
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

SPN90_HUMAN
NC score	0.110844 (rank : 70)	θ value	0.00390308 (rank : 62)
Query Neighborhood Hits	186	Target Neighborhood Hits	157	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

VINEX_HUMAN
NC score	0.109770 (rank : 71)	θ value	4.03905 (rank : 154)
Query Neighborhood Hits	186	Target Neighborhood Hits	270	Shared Neighborhood Hits	50
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

GRAP_MOUSE
NC score	0.108934 (rank : 72)	θ value	θ > 10 (rank : 236)
Query Neighborhood Hits	186	Target Neighborhood Hits	309	Shared Neighborhood Hits	55
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
NC score	0.106211 (rank : 73)	θ value	θ > 10 (rank : 237)
Query Neighborhood Hits	186	Target Neighborhood Hits	310	Shared Neighborhood Hits	55
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.106020 (rank : 74)	θ value	θ > 10 (rank : 238)
Query Neighborhood Hits	186	Target Neighborhood Hits	312	Shared Neighborhood Hits	55
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

SPN90_MOUSE
NC score	0.103864 (rank : 75)	θ value	0.00390308 (rank : 63)
Query Neighborhood Hits	186	Target Neighborhood Hits	157	Shared Neighborhood Hits	33
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

CRKL_HUMAN
NC score	0.102521 (rank : 76)	θ value	6.88961 (rank : 170)
Query Neighborhood Hits	186	Target Neighborhood Hits	313	Shared Neighborhood Hits	56
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
NC score	0.097915 (rank : 77)	θ value	1.06291 (rank : 106)
Query Neighborhood Hits	186	Target Neighborhood Hits	307	Shared Neighborhood Hits	55
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

NCK1_HUMAN
NC score	0.096808 (rank : 78)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	186	Target Neighborhood Hits	312	Shared Neighborhood Hits	52
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

STAC3_MOUSE
NC score	0.095845 (rank : 79)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	186	Target Neighborhood Hits	232	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

P55G_HUMAN
NC score	0.094718 (rank : 80)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	186	Target Neighborhood Hits	451	Shared Neighborhood Hits	29
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

CENB2_HUMAN
NC score	0.094475 (rank : 81)	θ value	θ > 10 (rank : 215)
Query Neighborhood Hits	186	Target Neighborhood Hits	425	Shared Neighborhood Hits	21
SwissProt Accessions	Q15057, Q9UQR3	Gene names	CENTB2, KIAA0041
Domain Architecture
Description	Centaurin-beta 2 (Cnt-b2).

STAC3_HUMAN
NC score	0.093301 (rank : 82)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	186	Target Neighborhood Hits	228	Shared Neighborhood Hits	50
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

P55G_MOUSE
NC score	0.093204 (rank : 83)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	186	Target Neighborhood Hits	401	Shared Neighborhood Hits	28
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

GRAP2_HUMAN
NC score	0.092846 (rank : 84)	θ value	θ > 10 (rank : 233)
Query Neighborhood Hits	186	Target Neighborhood Hits	304	Shared Neighborhood Hits	56
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

VAV3_HUMAN
NC score	0.092682 (rank : 85)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	186	Target Neighborhood Hits	398	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
NC score	0.091802 (rank : 86)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	186	Target Neighborhood Hits	404	Shared Neighborhood Hits	53
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ANM2_MOUSE
NC score	0.090753 (rank : 87)	θ value	0.0252991 (rank : 67)
Query Neighborhood Hits	186	Target Neighborhood Hits	175	Shared Neighborhood Hits	41
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

DDEF2_HUMAN
NC score	0.090060 (rank : 88)	θ value	0.0563607 (rank : 71)
Query Neighborhood Hits	186	Target Neighborhood Hits	599	Shared Neighborhood Hits	47
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

GRAP2_MOUSE
NC score	0.090014 (rank : 89)	θ value	θ > 10 (rank : 234)
Query Neighborhood Hits	186	Target Neighborhood Hits	297	Shared Neighborhood Hits	56
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

CENB5_HUMAN
NC score	0.089489 (rank : 90)	θ value	θ > 10 (rank : 216)
Query Neighborhood Hits	186	Target Neighborhood Hits	395	Shared Neighborhood Hits	17
SwissProt Accessions	Q96P50, Q9BSR9, Q9C0E7	Gene names	CENTB5, KIAA1716
Domain Architecture
Description	Centaurin-beta 5 (Cnt-b5).

CENB1_HUMAN
NC score	0.089064 (rank : 91)	θ value	θ > 10 (rank : 214)
Query Neighborhood Hits	186	Target Neighborhood Hits	383	Shared Neighborhood Hits	19
SwissProt Accessions	Q15027	Gene names	CENTB1, KIAA0050
Domain Architecture
Description	Centaurin-beta 1 (Cnt-b1).

NCF4_MOUSE
NC score	0.087877 (rank : 92)	θ value	5.27518 (rank : 160)
Query Neighborhood Hits	186	Target Neighborhood Hits	177	Shared Neighborhood Hits	39
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF2_HUMAN
NC score	0.087487 (rank : 93)	θ value	4.03905 (rank : 146)
Query Neighborhood Hits	186	Target Neighborhood Hits	229	Shared Neighborhood Hits	48
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

STAC_MOUSE
NC score	0.087448 (rank : 94)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	186	Target Neighborhood Hits	268	Shared Neighborhood Hits	50
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ANM2_HUMAN
NC score	0.087118 (rank : 95)	θ value	0.0961366 (rank : 76)
Query Neighborhood Hits	186	Target Neighborhood Hits	175	Shared Neighborhood Hits	41
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

GRP3_HUMAN
NC score	0.086993 (rank : 96)	θ value	θ > 10 (rank : 239)
Query Neighborhood Hits	186	Target Neighborhood Hits	131	Shared Neighborhood Hits	10
SwissProt Accessions	Q8IV61, O94931	Gene names	RASGRP3, GRP3, KIAA0846
Domain Architecture
Description	RAS guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1).

SPTA2_HUMAN
NC score	0.085757 (rank : 97)	θ value	0.00665767 (rank : 64)
Query Neighborhood Hits	186	Target Neighborhood Hits	888	Shared Neighborhood Hits	51
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

CD2AP_HUMAN
NC score	0.084984 (rank : 98)	θ value	θ > 10 (rank : 209)
Query Neighborhood Hits	186	Target Neighborhood Hits	315	Shared Neighborhood Hits	49
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

DDEF2_MOUSE
NC score	0.082574 (rank : 99)	θ value	θ > 10 (rank : 224)
Query Neighborhood Hits	186	Target Neighborhood Hits	625	Shared Neighborhood Hits	42
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

SH3K1_MOUSE
NC score	0.082193 (rank : 100)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	186	Target Neighborhood Hits	332	Shared Neighborhood Hits	50
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

STAC_HUMAN
NC score	0.082115 (rank : 101)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	186	Target Neighborhood Hits	276	Shared Neighborhood Hits	49
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

DNMBP_HUMAN
NC score	0.081927 (rank : 102)	θ value	θ > 10 (rank : 227)
Query Neighborhood Hits	186	Target Neighborhood Hits	413	Shared Neighborhood Hits	57
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

SPTA1_MOUSE
NC score	0.081862 (rank : 103)	θ value	1.06291 (rank : 114)
Query Neighborhood Hits	186	Target Neighborhood Hits	675	Shared Neighborhood Hits	55
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

ITSN1_MOUSE
NC score	0.081654 (rank : 104)	θ value	0.21417 (rank : 81)
Query Neighborhood Hits	186	Target Neighborhood Hits	1669	Shared Neighborhood Hits	84
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

VAV2_HUMAN
NC score	0.081303 (rank : 105)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	186	Target Neighborhood Hits	453	Shared Neighborhood Hits	52
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
NC score	0.081141 (rank : 106)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	186	Target Neighborhood Hits	456	Shared Neighborhood Hits	52
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ITSN1_HUMAN
NC score	0.080561 (rank : 107)	θ value	1.06291 (rank : 109)
Query Neighborhood Hits	186	Target Neighborhood Hits	1757	Shared Neighborhood Hits	89
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

CIP4_HUMAN
NC score	0.079599 (rank : 108)	θ value	θ > 10 (rank : 218)
Query Neighborhood Hits	186	Target Neighborhood Hits	374	Shared Neighborhood Hits	36
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

SH3K1_HUMAN
NC score	0.079545 (rank : 109)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	186	Target Neighborhood Hits	341	Shared Neighborhood Hits	50
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

HCLS1_HUMAN
NC score	0.078578 (rank : 110)	θ value	θ > 10 (rank : 240)
Query Neighborhood Hits	186	Target Neighborhood Hits	358	Shared Neighborhood Hits	53
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

ABI2_MOUSE
NC score	0.078495 (rank : 111)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	186	Target Neighborhood Hits	266	Shared Neighborhood Hits	50
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

DAPP1_MOUSE
NC score	0.078193 (rank : 112)	θ value	θ > 10 (rank : 222)
Query Neighborhood Hits	186	Target Neighborhood Hits	225	Shared Neighborhood Hits	32
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

ITSN2_HUMAN
NC score	0.077733 (rank : 113)	θ value	1.38821 (rank : 117)
Query Neighborhood Hits	186	Target Neighborhood Hits	1173	Shared Neighborhood Hits	65
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

HCLS1_MOUSE
NC score	0.077413 (rank : 114)	θ value	θ > 10 (rank : 241)
Query Neighborhood Hits	186	Target Neighborhood Hits	329	Shared Neighborhood Hits	51
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

DDEF1_MOUSE
NC score	0.077286 (rank : 115)	θ value	θ > 10 (rank : 223)
Query Neighborhood Hits	186	Target Neighborhood Hits	592	Shared Neighborhood Hits	43
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

ABI2_HUMAN
NC score	0.077092 (rank : 116)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	186	Target Neighborhood Hits	350	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

CD2AP_MOUSE
NC score	0.076918 (rank : 117)	θ value	θ > 10 (rank : 210)
Query Neighborhood Hits	186	Target Neighborhood Hits	336	Shared Neighborhood Hits	49
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

PPIP1_HUMAN
NC score	0.076642 (rank : 118)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	186	Target Neighborhood Hits	389	Shared Neighborhood Hits	53
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

ARHG7_MOUSE
NC score	0.076403 (rank : 119)	θ value	6.88961 (rank : 167)
Query Neighborhood Hits	186	Target Neighborhood Hits	396	Shared Neighborhood Hits	49
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

DNMBP_MOUSE
NC score	0.076316 (rank : 120)	θ value	θ > 10 (rank : 228)
Query Neighborhood Hits	186	Target Neighborhood Hits	435	Shared Neighborhood Hits	61
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

NCF4_HUMAN
NC score	0.076006 (rank : 121)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	186	Target Neighborhood Hits	161	Shared Neighborhood Hits	35
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

DAPP1_HUMAN
NC score	0.075974 (rank : 122)	θ value	θ > 10 (rank : 221)
Query Neighborhood Hits	186	Target Neighborhood Hits	227	Shared Neighborhood Hits	33
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

ITSN2_MOUSE
NC score	0.075395 (rank : 123)	θ value	1.81305 (rank : 123)
Query Neighborhood Hits	186	Target Neighborhood Hits	1371	Shared Neighborhood Hits	69
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

VAV_MOUSE
NC score	0.074080 (rank : 124)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	186	Target Neighborhood Hits	430	Shared Neighborhood Hits	55
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

CRK_HUMAN
NC score	0.074051 (rank : 125)	θ value	θ > 10 (rank : 219)
Query Neighborhood Hits	186	Target Neighborhood Hits	308	Shared Neighborhood Hits	51
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
NC score	0.073417 (rank : 126)	θ value	θ > 10 (rank : 220)
Query Neighborhood Hits	186	Target Neighborhood Hits	314	Shared Neighborhood Hits	51
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SPTA1_HUMAN
NC score	0.073417 (rank : 127)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	186	Target Neighborhood Hits	748	Shared Neighborhood Hits	52
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

NPHP1_MOUSE
NC score	0.072843 (rank : 128)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	186	Target Neighborhood Hits	267	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

SPTN4_HUMAN
NC score	0.071586 (rank : 129)	θ value	0.000158464 (rank : 59)
Query Neighborhood Hits	186	Target Neighborhood Hits	570	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

VAV_HUMAN
NC score	0.071543 (rank : 130)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	186	Target Neighborhood Hits	452	Shared Neighborhood Hits	54
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

PPIP1_MOUSE
NC score	0.070302 (rank : 131)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	186	Target Neighborhood Hits	377	Shared Neighborhood Hits	51
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

NPHP1_HUMAN
NC score	0.070075 (rank : 132)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	186	Target Neighborhood Hits	288	Shared Neighborhood Hits	42
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

DDFL1_HUMAN
NC score	0.068673 (rank : 133)	θ value	θ > 10 (rank : 225)
Query Neighborhood Hits	186	Target Neighborhood Hits	353	Shared Neighborhood Hits	14
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

ABI1_MOUSE
NC score	0.068477 (rank : 134)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	186	Target Neighborhood Hits	246	Shared Neighborhood Hits	47
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

PKHA1_HUMAN
NC score	0.067600 (rank : 135)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	186	Target Neighborhood Hits	127	Shared Neighborhood Hits	22
SwissProt Accessions	Q9HB21, Q9BVK0	Gene names	PLEKHA1, TAPP1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

ARHG4_HUMAN
NC score	0.066500 (rank : 136)	θ value	3.0926 (rank : 135)
Query Neighborhood Hits	186	Target Neighborhood Hits	242	Shared Neighborhood Hits	46
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG7_HUMAN
NC score	0.066310 (rank : 137)	θ value	θ > 10 (rank : 199)
Query Neighborhood Hits	186	Target Neighborhood Hits	347	Shared Neighborhood Hits	49
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

SLAP1_MOUSE
NC score	0.065599 (rank : 138)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	186	Target Neighborhood Hits	117	Shared Neighborhood Hits	22
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_MOUSE
NC score	0.064516 (rank : 139)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	186	Target Neighborhood Hits	136	Shared Neighborhood Hits	29
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

NCF1_MOUSE
NC score	0.064492 (rank : 140)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	186	Target Neighborhood Hits	198	Shared Neighborhood Hits	42
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

AHI1_MOUSE
NC score	0.064232 (rank : 141)	θ value	0.47712 (rank : 88)
Query Neighborhood Hits	186	Target Neighborhood Hits	496	Shared Neighborhood Hits	48
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

SMP1L_HUMAN
NC score	0.064135 (rank : 142)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	186	Target Neighborhood Hits	74	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WU79, Q5QPL2, Q96C93, Q9NST2, Q9UJL8	Gene names	SMAP1L
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like.

SMP1L_MOUSE
NC score	0.063954 (rank : 143)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	186	Target Neighborhood Hits	70	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TN29, Q3U798	Gene names	Smap1l, Smap2
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1-like (Stromal membrane- associated protein 2).

CENA2_HUMAN
NC score	0.063770 (rank : 144)	θ value	θ > 10 (rank : 212)
Query Neighborhood Hits	186	Target Neighborhood Hits	83	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NPF8, Q8N4Q6, Q96SD5	Gene names	CENTA2
Domain Architecture
Description	Centaurin-alpha 2.

NCF1_HUMAN
NC score	0.063743 (rank : 145)	θ value	1.06291 (rank : 111)
Query Neighborhood Hits	186	Target Neighborhood Hits	198	Shared Neighborhood Hits	42
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

SMAP1_HUMAN
NC score	0.062858 (rank : 146)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	186	Target Neighborhood Hits	98	Shared Neighborhood Hits	11
SwissProt Accessions	Q8IYB5, Q53H70, Q5SYQ2, Q6PK24, Q8NDH4, Q96L38, Q96L39, Q9H8X4	Gene names	SMAP1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

DDFL1_MOUSE
NC score	0.062855 (rank : 147)	θ value	θ > 10 (rank : 226)
Query Neighborhood Hits	186	Target Neighborhood Hits	324	Shared Neighborhood Hits	12
SwissProt Accessions	Q5U464	Gene names	Ddefl1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1.

AHI1_HUMAN
NC score	0.062825 (rank : 148)	θ value	θ > 10 (rank : 192)
Query Neighborhood Hits	186	Target Neighborhood Hits	537	Shared Neighborhood Hits	47
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ARHG9_HUMAN
NC score	0.062777 (rank : 149)	θ value	θ > 10 (rank : 200)
Query Neighborhood Hits	186	Target Neighborhood Hits	235	Shared Neighborhood Hits	42
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
NC score	0.062672 (rank : 150)	θ value	θ > 10 (rank : 201)
Query Neighborhood Hits	186	Target Neighborhood Hits	234	Shared Neighborhood Hits	41
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

SMAP1_MOUSE
NC score	0.062634 (rank : 151)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	186	Target Neighborhood Hits	120	Shared Neighborhood Hits	11
SwissProt Accessions	Q91VZ6, Q497I6, Q68EF3	Gene names	Smap1
Domain Architecture	No domain graphic available
Description	Stromal membrane-associated protein 1.

STAM2_MOUSE
NC score	0.062469 (rank : 152)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	186	Target Neighborhood Hits	285	Shared Neighborhood Hits	49
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

OSTF1_HUMAN
NC score	0.062405 (rank : 153)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	186	Target Neighborhood Hits	466	Shared Neighborhood Hits	47
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

SRC8_MOUSE
NC score	0.062398 (rank : 154)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	186	Target Neighborhood Hits	292	Shared Neighborhood Hits	45
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SPTN2_HUMAN
NC score	0.062081 (rank : 155)	θ value	0.0252991 (rank : 69)
Query Neighborhood Hits	186	Target Neighborhood Hits	535	Shared Neighborhood Hits	25
SwissProt Accessions	O15020, O14872, O14873	Gene names	SPTBN2, KIAA0302
Domain Architecture
Description	Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2) (Beta-III spectrin).

ABI1_HUMAN
NC score	0.061939 (rank : 156)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	186	Target Neighborhood Hits	257	Shared Neighborhood Hits	48
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

BNIP2_HUMAN
NC score	0.061912 (rank : 157)	θ value	θ > 10 (rank : 205)
Query Neighborhood Hits	186	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q12982	Gene names	BNIP2, NIP2
Domain Architecture
Description	BCL2/adenovirus E1B 19 kDa protein-interacting protein 2.

SLAP1_HUMAN
NC score	0.061803 (rank : 158)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	186	Target Neighborhood Hits	113	Shared Neighborhood Hits	22
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

BNIP2_MOUSE
NC score	0.061778 (rank : 159)	θ value	θ > 10 (rank : 206)
Query Neighborhood Hits	186	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	O54940	Gene names	Bnip2, Nip2l
Domain Architecture
Description	BCL2/adenovirus E1B 19 kDa protein-interacting protein 2.

SPTB2_HUMAN
NC score	0.061468 (rank : 160)	θ value	0.0252991 (rank : 68)
Query Neighborhood Hits	186	Target Neighborhood Hits	748	Shared Neighborhood Hits	25
SwissProt Accessions	Q01082, O60837, Q16057	Gene names	SPTBN1, SPTB2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

CENA1_HUMAN
NC score	0.061457 (rank : 161)	θ value	θ > 10 (rank : 211)
Query Neighborhood Hits	186	Target Neighborhood Hits	87	Shared Neighborhood Hits	10
SwissProt Accessions	O75689	Gene names	CENTA1
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 1 (Putative MAPK-activating protein PM25).

SPTB2_MOUSE
NC score	0.061342 (rank : 162)	θ value	0.00665767 (rank : 65)
Query Neighborhood Hits	186	Target Neighborhood Hits	770	Shared Neighborhood Hits	24
SwissProt Accessions	Q62261, Q5SQL8	Gene names	Sptbn1, Spnb-2, Spnb2, Sptb2
Domain Architecture
Description	Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1) (Beta-II spectrin) (Fodrin beta chain).

PDZD8_HUMAN
NC score	0.061260 (rank : 163)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	186	Target Neighborhood Hits	185	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NEN9, Q86WE0, Q86WE5, Q9UFF1	Gene names	PDZD8, PDZK8
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 8 (Sarcoma antigen NY-SAR-84/NY-SAR- 104).

SRC8_HUMAN
NC score	0.060785 (rank : 164)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	186	Target Neighborhood Hits	269	Shared Neighborhood Hits	46
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

STAM2_HUMAN
NC score	0.059692 (rank : 165)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	186	Target Neighborhood Hits	288	Shared Neighborhood Hits	46
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

CENG1_MOUSE
NC score	0.059602 (rank : 166)	θ value	6.88961 (rank : 169)
Query Neighborhood Hits	186	Target Neighborhood Hits	531	Shared Neighborhood Hits	23
SwissProt Accessions	Q3UHD9, Q5DU45	Gene names	Centg1, Agap2, Kiaa0167
Domain Architecture	No domain graphic available
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE).

UN13B_HUMAN
NC score	0.058956 (rank : 167)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	186	Target Neighborhood Hits	217	Shared Neighborhood Hits	22
SwissProt Accessions	O14795	Gene names	UNC13B, UNC13
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

OSTF1_MOUSE
NC score	0.058900 (rank : 168)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	186	Target Neighborhood Hits	467	Shared Neighborhood Hits	47
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

ATCAY_MOUSE
NC score	0.058871 (rank : 169)	θ value	θ > 10 (rank : 203)
Query Neighborhood Hits	186	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BHE3, Q3TR94	Gene names	Atcay
Domain Architecture
Description	Caytaxin.

FA13A_MOUSE
NC score	0.058765 (rank : 170)	θ value	θ > 10 (rank : 232)
Query Neighborhood Hits	186	Target Neighborhood Hits	83	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BGI4, Q8BZ91	Gene names	Fam13a1, Precm1
Domain Architecture	No domain graphic available
Description	Protein FAM13A1 (Precm1 protein).

UN13A_HUMAN
NC score	0.058597 (rank : 171)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	186	Target Neighborhood Hits	285	Shared Neighborhood Hits	24
SwissProt Accessions	Q9UPW8	Gene names	UNC13A, KIAA1032
Domain Architecture	No domain graphic available
Description	Unc-13 homolog A (Munc13-1).

DP13A_HUMAN
NC score	0.058551 (rank : 172)	θ value	θ > 10 (rank : 229)
Query Neighborhood Hits	186	Target Neighborhood Hits	107	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UKG1, Q9P2B9	Gene names	APPL1, APPL, DIP13A, KIAA1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

STAM1_MOUSE
NC score	0.058413 (rank : 173)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	186	Target Neighborhood Hits	273	Shared Neighborhood Hits	45
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ARHG6_MOUSE
NC score	0.058395 (rank : 174)	θ value	θ > 10 (rank : 198)
Query Neighborhood Hits	186	Target Neighborhood Hits	394	Shared Neighborhood Hits	45
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARFG3_MOUSE
NC score	0.058340 (rank : 175)	θ value	θ > 10 (rank : 196)
Query Neighborhood Hits	186	Target Neighborhood Hits	80	Shared Neighborhood Hits	8
SwissProt Accessions	Q9D8S3, Q99KN8	Gene names	Arfgap3
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

ATCAY_HUMAN
NC score	0.058335 (rank : 176)	θ value	θ > 10 (rank : 202)
Query Neighborhood Hits	186	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q86WG3, Q8NAQ2, Q8TAQ3, Q96HC6, Q96JF5	Gene names	ATCAY, KIAA1872
Domain Architecture
Description	Caytaxin (Ataxia Cayman type protein) (BNIP-H).

STAM1_HUMAN
NC score	0.058320 (rank : 177)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	186	Target Neighborhood Hits	271	Shared Neighborhood Hits	47
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

ARFG3_HUMAN
NC score	0.057941 (rank : 178)	θ value	θ > 10 (rank : 195)
Query Neighborhood Hits	186	Target Neighborhood Hits	56	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NP61, Q9BSC6, Q9H9J0, Q9NT10, Q9NUP5, Q9Y4V3, Q9Y4V4	Gene names	ARFGAP3, ARFGAP1
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 3 (ARF GAP 3).

FA13A_HUMAN
NC score	0.057839 (rank : 179)	θ value	θ > 10 (rank : 231)
Query Neighborhood Hits	186	Target Neighborhood Hits	102	Shared Neighborhood Hits	2
SwissProt Accessions	O94988, Q8NBA3	Gene names	FAM13A1, KIAA0914
Domain Architecture	No domain graphic available
Description	Protein FAM13A1.

BNIPL_HUMAN
NC score	0.057643 (rank : 180)	θ value	θ > 10 (rank : 207)
Query Neighborhood Hits	186	Target Neighborhood Hits	40	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z465, Q6DK43, Q8TCY7, Q8WYG2	Gene names	BNIPL
Domain Architecture	No domain graphic available
Description	Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein.

PKHA1_MOUSE
NC score	0.057180 (rank : 181)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	186	Target Neighborhood Hits	120	Shared Neighborhood Hits	20
SwissProt Accessions	Q8BUL6, Q8BK96, Q8BXU1, Q8VE13	Gene names	Plekha1, Tapp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 1 (Tandem PH domain-containing protein 1) (TAPP-1).

BNIPL_MOUSE
NC score	0.057161 (rank : 182)	θ value	θ > 10 (rank : 208)
Query Neighborhood Hits	186	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q99JU7, Q923E3	Gene names	Bnipl
Domain Architecture	No domain graphic available
Description	Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein.

SH3G2_MOUSE
NC score	0.056188 (rank : 183)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	186	Target Neighborhood Hits	319	Shared Neighborhood Hits	42
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

CENA2_MOUSE
NC score	0.056169 (rank : 184)	θ value	θ > 10 (rank : 213)
Query Neighborhood Hits	186	Target Neighborhood Hits	68	Shared Neighborhood Hits	9
SwissProt Accessions	Q8R2V5	Gene names	Centa2
Domain Architecture	No domain graphic available
Description	Centaurin-alpha 2.

SLAP2_HUMAN
NC score	0.056120 (rank : 185)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	186	Target Neighborhood Hits	139	Shared Neighborhood Hits	28
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

ARHG6_HUMAN
NC score	0.055915 (rank : 186)	θ value	θ > 10 (rank : 197)
Query Neighborhood Hits	186	Target Neighborhood Hits	376	Shared Neighborhood Hits	47
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

SH3G2_HUMAN
NC score	0.055803 (rank : 187)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	186	Target Neighborhood Hits	324	Shared Neighborhood Hits	44
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

CENG1_HUMAN
NC score	0.055749 (rank : 188)	θ value	θ > 10 (rank : 217)
Query Neighborhood Hits	186	Target Neighborhood Hits	544	Shared Neighborhood Hits	18
SwissProt Accessions	Q99490, O00578, Q548E0, Q8IWU3	Gene names	CENTG1, AGAP2, KIAA0167
Domain Architecture
Description	Centaurin-gamma 1 (ARF-GAP with GTP-binding protein-like, ankyrin repeat and pleckstrin homology domains 2) (AGAP-2) (Phosphatidylinositol-3-kinase enhancer) (PIKE) (GTP-binding and GTPase-activating protein 2) (GGAP2).

ARFG1_MOUSE
NC score	0.055485 (rank : 189)	θ value	θ > 10 (rank : 194)
Query Neighborhood Hits	186	Target Neighborhood Hits	51	Shared Neighborhood Hits	8
SwissProt Accessions	Q9EPJ9, Q3TI52, Q8BMM6, Q8BMQ7	Gene names	Arfgap1, Arf1gap
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

UN13B_MOUSE
NC score	0.055403 (rank : 190)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	186	Target Neighborhood Hits	210	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z1N9	Gene names	Unc13b, Unc13a
Domain Architecture	No domain graphic available
Description	Unc-13 homolog B (Munc13-2) (munc13).

DP13A_MOUSE
NC score	0.054786 (rank : 191)	θ value	θ > 10 (rank : 230)
Query Neighborhood Hits	186	Target Neighborhood Hits	96	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K3H0, Q3UJP7, Q69ZJ9, Q8BWZ8, Q8VCJ8, Q9CUW4	Gene names	Appl1, Dip13a, Kiaa1428
Domain Architecture	No domain graphic available
Description	DCC-interacting protein 13 alpha (Dip13 alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1).

PCTL_MOUSE
NC score	0.054782 (rank : 192)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	186	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9JMD3	Gene names	Stard10, Pctpl, Sdccag28, Sdccagg28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28 homolog).

RASA1_HUMAN
NC score	0.054630 (rank : 193)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	186	Target Neighborhood Hits	258	Shared Neighborhood Hits	32
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

PLCG2_HUMAN
NC score	0.054291 (rank : 194)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	186	Target Neighborhood Hits	280	Shared Neighborhood Hits	45
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PCTL_HUMAN
NC score	0.054161 (rank : 195)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	186	Target Neighborhood Hits	26	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y365, O60532	Gene names	STARD10, SDCCAG28
Domain Architecture
Description	PCTP-like protein (PCTP-L) (StAR-related lipid transfer protein 10) (StARD10) (START domain-containing protein 10) (Serologically defined colon cancer antigen 28) (Antigen NY-CO-28).

PACN2_HUMAN
NC score	0.054118 (rank : 196)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	186	Target Neighborhood Hits	339	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN1_MOUSE
NC score	0.053646 (rank : 197)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	186	Target Neighborhood Hits	283	Shared Neighborhood Hits	47
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PLCG1_MOUSE
NC score	0.053361 (rank : 198)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	186	Target Neighborhood Hits	314	Shared Neighborhood Hits	52
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

MYO1F_MOUSE
NC score	0.053303 (rank : 199)	θ value	θ > 10 (rank : 244)
Query Neighborhood Hits	186	Target Neighborhood Hits	262	Shared Neighborhood Hits	44
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

PRP40_HUMAN
NC score	0.053265 (rank : 200)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	186	Target Neighborhood Hits	442	Shared Neighborhood Hits	25
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

MYO1F_HUMAN
NC score	0.053247 (rank : 201)	θ value	θ > 10 (rank : 243)
Query Neighborhood Hits	186	Target Neighborhood Hits	275	Shared Neighborhood Hits	44
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

SH3G1_HUMAN
NC score	0.052997 (rank : 202)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	186	Target Neighborhood Hits	307	Shared Neighborhood Hits	39
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

PLCG1_HUMAN
NC score	0.052820 (rank : 203)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	186	Target Neighborhood Hits	293	Shared Neighborhood Hits	52
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PACN1_HUMAN
NC score	0.052779 (rank : 204)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	186	Target Neighborhood Hits	320	Shared Neighborhood Hits	47
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PLEK2_MOUSE
NC score	0.052676 (rank : 205)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	186	Target Neighborhood Hits	96	Shared Neighborhood Hits	9
SwissProt Accessions	Q9WV52	Gene names	Plek2
Domain Architecture
Description	Pleckstrin-2.

GAS7_MOUSE
NC score	0.052487 (rank : 206)	θ value	6.88961 (rank : 171)
Query Neighborhood Hits	186	Target Neighborhood Hits	259	Shared Neighborhood Hits	22
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

GAS7_HUMAN
NC score	0.052279 (rank : 207)	θ value	2.36792 (rank : 131)
Query Neighborhood Hits	186	Target Neighborhood Hits	258	Shared Neighborhood Hits	22
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

PLEK_HUMAN
NC score	0.052249 (rank : 208)	θ value	1.38821 (rank : 121)
Query Neighborhood Hits	186	Target Neighborhood Hits	110	Shared Neighborhood Hits	17
SwissProt Accessions	P08567, Q53SU8, Q6FGM8, Q8WV81	Gene names	PLEK, P47
Domain Architecture
Description	Pleckstrin (Platelet p47 protein).

MYO1E_HUMAN
NC score	0.051844 (rank : 209)	θ value	θ > 10 (rank : 242)
Query Neighborhood Hits	186	Target Neighborhood Hits	293	Shared Neighborhood Hits	46
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

SH21A_HUMAN
NC score	0.051552 (rank : 210)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	186	Target Neighborhood Hits	89	Shared Neighborhood Hits	15
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

ARFG1_HUMAN
NC score	0.051462 (rank : 211)	θ value	θ > 10 (rank : 193)
Query Neighborhood Hits	186	Target Neighborhood Hits	60	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N6T3, Q96KC4, Q96T02, Q9NSU3, Q9NVF6, Q9UIL0	Gene names	ARFGAP1, ARF1GAP
Domain Architecture
Description	ADP-ribosylation factor GTPase-activating protein 1 (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase- activating protein) (GAP protein).

BCAR1_MOUSE
NC score	0.051045 (rank : 212)	θ value	θ > 10 (rank : 204)
Query Neighborhood Hits	186	Target Neighborhood Hits	438	Shared Neighborhood Hits	58
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

PACN2_MOUSE
NC score	0.050873 (rank : 213)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	186	Target Neighborhood Hits	382	Shared Neighborhood Hits	50
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

SH21A_MOUSE
NC score	0.050740 (rank : 214)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	186	Target Neighborhood Hits	89	Shared Neighborhood Hits	15
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

PRP40_MOUSE
NC score	0.050534 (rank : 215)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	186	Target Neighborhood Hits	447	Shared Neighborhood Hits	24
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

ABI3_MOUSE
NC score	0.050407 (rank : 216)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	186	Target Neighborhood Hits	227	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

TIAM1_HUMAN
NC score	0.049490 (rank : 217)	θ value	6.88961 (rank : 177)
Query Neighborhood Hits	186	Target Neighborhood Hits	225	Shared Neighborhood Hits	22
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

PLEK_MOUSE
NC score	0.048242 (rank : 218)	θ value	0.47712 (rank : 91)
Query Neighborhood Hits	186	Target Neighborhood Hits	109	Shared Neighborhood Hits	15
SwissProt Accessions	Q9JHK5, Q9ERI9	Gene names	Plek
Domain Architecture
Description	Pleckstrin.

NOXO1_MOUSE
NC score	0.047076 (rank : 219)	θ value	6.88961 (rank : 174)
Query Neighborhood Hits	186	Target Neighborhood Hits	114	Shared Neighborhood Hits	26
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

PIN1_MOUSE
NC score	0.044560 (rank : 220)	θ value	1.06291 (rank : 113)
Query Neighborhood Hits	186	Target Neighborhood Hits	60	Shared Neighborhood Hits	14
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

CNKR1_HUMAN
NC score	0.044343 (rank : 221)	θ value	0.813845 (rank : 97)
Query Neighborhood Hits	186	Target Neighborhood Hits	154	Shared Neighborhood Hits	13
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

FGR_MOUSE
NC score	0.043922 (rank : 222)	θ value	0.0736092 (rank : 75)
Query Neighborhood Hits	186	Target Neighborhood Hits	1069	Shared Neighborhood Hits	59
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

YES_MOUSE
NC score	0.043710 (rank : 223)	θ value	0.0563607 (rank : 74)
Query Neighborhood Hits	186	Target Neighborhood Hits	1052	Shared Neighborhood Hits	60
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FGR_HUMAN
NC score	0.043616 (rank : 224)	θ value	1.06291 (rank : 107)
Query Neighborhood Hits	186	Target Neighborhood Hits	1067	Shared Neighborhood Hits	59
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

YES_HUMAN
NC score	0.042289 (rank : 225)	θ value	0.163984 (rank : 80)
Query Neighborhood Hits	186	Target Neighborhood Hits	1059	Shared Neighborhood Hits	59
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

PKHA4_MOUSE
NC score	0.041647 (rank : 226)	θ value	8.99809 (rank : 184)
Query Neighborhood Hits	186	Target Neighborhood Hits	202	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VC98, Q8R3N3	Gene names	Plekha4, Pepp1
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 4 (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1).

WBP4_MOUSE
NC score	0.040827 (rank : 227)	θ value	3.0926 (rank : 142)
Query Neighborhood Hits	186	Target Neighborhood Hits	100	Shared Neighborhood Hits	16
SwissProt Accessions	Q61048, Q8K1Z9, Q9CS45	Gene names	Wbp4, Fbp21, Fnbp21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

FYN_MOUSE
NC score	0.040515 (rank : 228)	θ value	0.813845 (rank : 99)
Query Neighborhood Hits	186	Target Neighborhood Hits	1073	Shared Neighborhood Hits	59
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

SRC_HUMAN
NC score	0.040164 (rank : 229)	θ value	0.279714 (rank : 84)
Query Neighborhood Hits	186	Target Neighborhood Hits	1058	Shared Neighborhood Hits	59
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

PIN1_HUMAN
NC score	0.039507 (rank : 230)	θ value	1.38821 (rank : 120)
Query Neighborhood Hits	186	Target Neighborhood Hits	59	Shared Neighborhood Hits	13
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

YAP1_HUMAN
NC score	0.039321 (rank : 231)	θ value	1.81305 (rank : 128)
Query Neighborhood Hits	186	Target Neighborhood Hits	173	Shared Neighborhood Hits	21
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

FYN_HUMAN
NC score	0.039144 (rank : 232)	θ value	0.813845 (rank : 98)
Query Neighborhood Hits	186	Target Neighborhood Hits	1078	Shared Neighborhood Hits	58
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

ITCH_MOUSE
NC score	0.038903 (rank : 233)	θ value	0.62314 (rank : 92)
Query Neighborhood Hits	186	Target Neighborhood Hits	127	Shared Neighborhood Hits	22
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

ITCH_HUMAN
NC score	0.038172 (rank : 234)	θ value	0.47712 (rank : 89)
Query Neighborhood Hits	186	Target Neighborhood Hits	162	Shared Neighborhood Hits	22
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

GSCR1_HUMAN
NC score	0.034439 (rank : 235)	θ value	0.813845 (rank : 100)
Query Neighborhood Hits	186	Target Neighborhood Hits	674	Shared Neighborhood Hits	24
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

MILK1_MOUSE
NC score	0.033246 (rank : 236)	θ value	8.99809 (rank : 179)
Query Neighborhood Hits	186	Target Neighborhood Hits	788	Shared Neighborhood Hits	34
SwissProt Accessions	Q8BGT6, Q8BJ60	Gene names	Mirab13, D15Mit260, Kiaa1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

BTK_HUMAN
NC score	0.032888 (rank : 237)	θ value	1.38821 (rank : 115)
Query Neighborhood Hits	186	Target Neighborhood Hits	1026	Shared Neighborhood Hits	53
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

PHC3_MOUSE
NC score	0.032654 (rank : 238)	θ value	0.365318 (rank : 86)
Query Neighborhood Hits	186	Target Neighborhood Hits	194	Shared Neighborhood Hits	9
SwissProt Accessions	Q8CHP6, Q3TLV5	Gene names	Phc3
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 3.

FRK_HUMAN
NC score	0.030466 (rank : 239)	θ value	0.163984 (rank : 79)
Query Neighborhood Hits	186	Target Neighborhood Hits	1058	Shared Neighborhood Hits	55
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

PHC3_HUMAN
NC score	0.030378 (rank : 240)	θ value	0.47712 (rank : 90)
Query Neighborhood Hits	186	Target Neighborhood Hits	218	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NDX5, Q5HYF0, Q6NSG2, Q8NFT7, Q8NFZ1, Q8TBM2, Q9H971, Q9H9I4	Gene names	PHC3, EDR3, PH3
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 3 (hPH3) (Homolog of polyhomeotic 3) (Early development regulatory protein 3).

YLPM1_HUMAN
NC score	0.030338 (rank : 241)	θ value	0.813845 (rank : 104)
Query Neighborhood Hits	186	Target Neighborhood Hits	670	Shared Neighborhood Hits	22
SwissProt Accessions	P49750, P49752, Q96I64, Q9P1V7	Gene names	YLPM1, C14orf170, ZAP3
Domain Architecture
Description	YLP motif-containing protein 1 (Nuclear protein ZAP3) (ZAP113).

SMUF2_HUMAN
NC score	0.029497 (rank : 242)	θ value	5.27518 (rank : 163)
Query Neighborhood Hits	186	Target Neighborhood Hits	142	Shared Neighborhood Hits	19
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SRRM1_MOUSE
NC score	0.028485 (rank : 243)	θ value	5.27518 (rank : 164)
Query Neighborhood Hits	186	Target Neighborhood Hits	966	Shared Neighborhood Hits	36
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

NED4L_HUMAN
NC score	0.028222 (rank : 244)	θ value	4.03905 (rank : 147)
Query Neighborhood Hits	186	Target Neighborhood Hits	238	Shared Neighborhood Hits	23
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_MOUSE
NC score	0.027858 (rank : 245)	θ value	4.03905 (rank : 148)
Query Neighborhood Hits	186	Target Neighborhood Hits	231	Shared Neighborhood Hits	22
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NEDD4_HUMAN
NC score	0.027494 (rank : 246)	θ value	5.27518 (rank : 161)
Query Neighborhood Hits	186	Target Neighborhood Hits	214	Shared Neighborhood Hits	19
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

BLK_MOUSE
NC score	0.027032 (rank : 247)	θ value	0.125558 (rank : 78)
Query Neighborhood Hits	186	Target Neighborhood Hits	992	Shared Neighborhood Hits	47
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

RGS3_HUMAN
NC score	0.026354 (rank : 248)	θ value	0.62314 (rank : 93)
Query Neighborhood Hits	186	Target Neighborhood Hits	1375	Shared Neighborhood Hits	48
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

TEC_HUMAN
NC score	0.026258 (rank : 249)	θ value	1.81305 (rank : 126)
Query Neighborhood Hits	186	Target Neighborhood Hits	1006	Shared Neighborhood Hits	49
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

GGN_HUMAN
NC score	0.026109 (rank : 250)	θ value	4.03905 (rank : 145)
Query Neighborhood Hits	186	Target Neighborhood Hits	269	Shared Neighborhood Hits	16
SwissProt Accessions	Q86UU5, Q7RTU6, Q86UU4, Q8NAA1	Gene names	GGN
Domain Architecture	No domain graphic available
Description	Gametogenetin.

NACAM_MOUSE
NC score	0.025683 (rank : 251)	θ value	8.99809 (rank : 180)
Query Neighborhood Hits	186	Target Neighborhood Hits	1866	Shared Neighborhood Hits	57
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

BLK_HUMAN
NC score	0.025649 (rank : 252)	θ value	1.06291 (rank : 105)
Query Neighborhood Hits	186	Target Neighborhood Hits	994	Shared Neighborhood Hits	49
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

OGFR_HUMAN
NC score	0.023301 (rank : 253)	θ value	8.99809 (rank : 182)
Query Neighborhood Hits	186	Target Neighborhood Hits	1582	Shared Neighborhood Hits	50
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

5NT1B_HUMAN
NC score	0.022633 (rank : 254)	θ value	0.813845 (rank : 96)
Query Neighborhood Hits	186	Target Neighborhood Hits	83	Shared Neighborhood Hits	5
SwissProt Accessions	Q96P26, Q8N9W3, Q8NA26, Q96DU5, Q96KE6, Q96M25, Q96SA3	Gene names	NT5C1B, AIRP
Domain Architecture
Description	Cytosolic 5'-nucleotidase 1B (EC 3.1.3.5) (Cytosolic 5'-nucleotidase IB) (cN1B) (cN-IB) (Autoimmune infertility-related protein).

K2002_HUMAN
NC score	0.022256 (rank : 255)	θ value	1.38821 (rank : 118)
Query Neighborhood Hits	186	Target Neighborhood Hits	274	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H792, Q6ZS78, Q8NCM3	Gene names	KIAA2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

K2002_MOUSE
NC score	0.021773 (rank : 256)	θ value	2.36792 (rank : 133)
Query Neighborhood Hits	186	Target Neighborhood Hits	267	Shared Neighborhood Hits	5
SwissProt Accessions	Q69Z38, Q8R365	Gene names	Kiaa2002
Domain Architecture	No domain graphic available
Description	Uncharacterized tyrosine-protein kinase KIAA2002 (EC 2.7.10.2).

NFAC2_HUMAN
NC score	0.021478 (rank : 257)	θ value	1.06291 (rank : 112)
Query Neighborhood Hits	186	Target Neighborhood Hits	101	Shared Neighborhood Hits	9
SwissProt Accessions	Q13469, Q13468, Q5TFW7, Q5TFW8, Q9NPX6, Q9NQH3, Q9UJR2	Gene names	NFATC2, NFAT1, NFATP
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 2 (T cell transcription factor NFAT1) (NFAT pre-existing subunit) (NF-ATp).

SYP2L_MOUSE
NC score	0.021395 (rank : 258)	θ value	0.62314 (rank : 95)
Query Neighborhood Hits	186	Target Neighborhood Hits	289	Shared Neighborhood Hits	16
SwissProt Accessions	Q8BWB1	Gene names	Synpo2l
Domain Architecture	No domain graphic available
Description	Synaptopodin 2-like protein.

PSD4_HUMAN
NC score	0.021237 (rank : 259)	θ value	8.99809 (rank : 185)
Query Neighborhood Hits	186	Target Neighborhood Hits	178	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NDX1, O95621, Q4ZG34, Q6GPH8, Q8IYP4	Gene names	PSD4, EFA6B, TIC
Domain Architecture	No domain graphic available
Description	PH and SEC7 domain-containing protein 4 (Pleckstrin homology and SEC7 domain-containing protein 4) (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B) (Telomeric of interleukin-1 cluster protein).

NFAC2_MOUSE
NC score	0.020629 (rank : 260)	θ value	1.38821 (rank : 119)
Query Neighborhood Hits	186	Target Neighborhood Hits	98	Shared Neighborhood Hits	10
SwissProt Accessions	Q60591, Q60984, Q60985	Gene names	Nfatc2, Nfat1, Nfatp
Domain Architecture
Description	Nuclear factor of activated T-cells, cytoplasmic 2 (T cell transcription factor NFAT1) (NFAT pre-existing subunit) (NF-ATp).

CSKI2_MOUSE
NC score	0.020511 (rank : 261)	θ value	1.38821 (rank : 116)
Query Neighborhood Hits	186	Target Neighborhood Hits	812	Shared Neighborhood Hits	32
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

DLG4_HUMAN
NC score	0.020244 (rank : 262)	θ value	0.279714 (rank : 82)
Query Neighborhood Hits	186	Target Neighborhood Hits	286	Shared Neighborhood Hits	26
SwissProt Accessions	P78352, Q92941, Q9UKK8	Gene names	DLG4, PSD95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

DLG4_MOUSE
NC score	0.019065 (rank : 263)	θ value	0.365318 (rank : 85)
Query Neighborhood Hits	186	Target Neighborhood Hits	282	Shared Neighborhood Hits	25
SwissProt Accessions	Q62108, Q5NCV5, Q5NCV6, Q5NCV7, Q91WJ1	Gene names	Dlg4, Dlgh4, Psd95
Domain Architecture
Description	Discs large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP90).

MLL2_HUMAN
NC score	0.018923 (rank : 264)	θ value	5.27518 (rank : 159)
Query Neighborhood Hits	186	Target Neighborhood Hits	1788	Shared Neighborhood Hits	48
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

NCOA6_MOUSE
NC score	0.018358 (rank : 265)	θ value	6.88961 (rank : 173)
Query Neighborhood Hits	186	Target Neighborhood Hits	1076	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

CSPG2_MOUSE
NC score	0.017831 (rank : 266)	θ value	0.0563607 (rank : 70)
Query Neighborhood Hits	186	Target Neighborhood Hits	711	Shared Neighborhood Hits	14
SwissProt Accessions	Q62059, Q62058, Q9CUU0	Gene names	Cspg2
Domain Architecture
Description	Versican core protein precursor (Large fibroblast proteoglycan) (Chondroitin sulfate proteoglycan core protein 2) (PG-M).

GA2L2_MOUSE
NC score	0.017423 (rank : 267)	θ value	1.06291 (rank : 108)
Query Neighborhood Hits	186	Target Neighborhood Hits	395	Shared Neighborhood Hits	18
SwissProt Accessions	Q5SSG4	Gene names	Gas2l2
Domain Architecture	No domain graphic available
Description	GAS2-like protein 2 (Growth arrest-specific 2-like 2).

FRMD5_HUMAN
NC score	0.017278 (rank : 268)	θ value	0.0961366 (rank : 77)
Query Neighborhood Hits	186	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q7Z6J6, Q8NBG4	Gene names	FRMD5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

SRMS_MOUSE
NC score	0.016049 (rank : 269)	θ value	1.81305 (rank : 125)
Query Neighborhood Hits	186	Target Neighborhood Hits	964	Shared Neighborhood Hits	37
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

GCP60_HUMAN
NC score	0.015710 (rank : 270)	θ value	2.36792 (rank : 132)
Query Neighborhood Hits	186	Target Neighborhood Hits	419	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H3P7, Q5VTJ0, Q6P9F1, Q8IZC5, Q8N4D6, Q9H6U3	Gene names	ACBD3, GCP60
Domain Architecture	No domain graphic available
Description	Golgi resident protein GCP60 (Acyl-CoA-binding domain-containing protein 3) (Golgi phosphoprotein 1) (GOLPH1) (Golgi complex-associated protein 1) (GOCAP1) (PBR- and PKA-associated protein 7) (Peripheral benzodiazepine receptor-associated protein PAP7).

AZI1_MOUSE
NC score	0.015342 (rank : 271)	θ value	6.88961 (rank : 168)
Query Neighborhood Hits	186	Target Neighborhood Hits	990	Shared Neighborhood Hits	23
SwissProt Accessions	Q62036	Gene names	Azi1, Az1, Azi
Domain Architecture
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1).

MLL3_MOUSE
NC score	0.015015 (rank : 272)	θ value	3.0926 (rank : 139)
Query Neighborhood Hits	186	Target Neighborhood Hits	1399	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

K1802_HUMAN
NC score	0.014560 (rank : 273)	θ value	6.88961 (rank : 172)
Query Neighborhood Hits	186	Target Neighborhood Hits	1378	Shared Neighborhood Hits	38
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

RCOR3_MOUSE
NC score	0.014482 (rank : 274)	θ value	4.03905 (rank : 150)
Query Neighborhood Hits	186	Target Neighborhood Hits	110	Shared Neighborhood Hits	8
SwissProt Accessions	Q6PGA0	Gene names	Rcor3
Domain Architecture	No domain graphic available
Description	REST corepressor 3.

RCOR3_HUMAN
NC score	0.014244 (rank : 275)	θ value	4.03905 (rank : 149)
Query Neighborhood Hits	186	Target Neighborhood Hits	161	Shared Neighborhood Hits	12
SwissProt Accessions	Q9P2K3, Q5VT47, Q7L9I5, Q8N5U3, Q9NV83	Gene names	RCOR3, KIAA1343
Domain Architecture	No domain graphic available
Description	REST corepressor 3.

UBP2L_HUMAN
NC score	0.013540 (rank : 276)	θ value	5.27518 (rank : 166)
Query Neighborhood Hits	186	Target Neighborhood Hits	170	Shared Neighborhood Hits	8
SwissProt Accessions	Q14157, Q5VU75, Q5VU76, Q9BTU3, Q9UGL5	Gene names	UBAP2L, KIAA0144, NICE4
Domain Architecture
Description	Ubiquitin-associated protein 2-like (Protein NICE-4).

PHLB1_MOUSE
NC score	0.012724 (rank : 277)	θ value	8.99809 (rank : 183)
Query Neighborhood Hits	186	Target Neighborhood Hits	678	Shared Neighborhood Hits	27
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

FRMD5_MOUSE
NC score	0.012523 (rank : 278)	θ value	3.0926 (rank : 138)
Query Neighborhood Hits	186	Target Neighborhood Hits	55	Shared Neighborhood Hits	4
SwissProt Accessions	Q6P5H6, Q6PFH6, Q8C0K0	Gene names	Frmd5
Domain Architecture	No domain graphic available
Description	FERM domain-containing protein 5.

TSC2_HUMAN
NC score	0.012037 (rank : 279)	θ value	3.0926 (rank : 141)
Query Neighborhood Hits	186	Target Neighborhood Hits	59	Shared Neighborhood Hits	3
SwissProt Accessions	P49815, O75275, Q8TAZ1	Gene names	TSC2
Domain Architecture
Description	Tuberin (Tuberous sclerosis 2 protein).

C2TA_MOUSE
NC score	0.011381 (rank : 280)	θ value	2.36792 (rank : 129)
Query Neighborhood Hits	186	Target Neighborhood Hits	131	Shared Neighborhood Hits	4
SwissProt Accessions	P79621, O46787, O78036, O78109, Q31115, Q9TPP1	Gene names	Ciita, C2ta, Mhc2ta
Domain Architecture
Description	MHC class II transactivator (CIITA).

PGCB_MOUSE
NC score	0.011168 (rank : 281)	θ value	0.813845 (rank : 103)
Query Neighborhood Hits	186	Target Neighborhood Hits	459	Shared Neighborhood Hits	7
SwissProt Accessions	Q61361	Gene names	Bcan
Domain Architecture
Description	Brevican core protein precursor.

MAGC1_HUMAN
NC score	0.010972 (rank : 282)	θ value	1.06291 (rank : 110)
Query Neighborhood Hits	186	Target Neighborhood Hits	431	Shared Neighborhood Hits	13
SwissProt Accessions	O60732, O75451, Q8TCV4	Gene names	MAGEC1
Domain Architecture
Description	Melanoma-associated antigen C1 (MAGE-C1 antigen) (Cancer-testis antigen CT7).

TJAP1_MOUSE
NC score	0.010792 (rank : 283)	θ value	5.27518 (rank : 165)
Query Neighborhood Hits	186	Target Neighborhood Hits	295	Shared Neighborhood Hits	5
SwissProt Accessions	Q9DCD5, Q8CFL7, Q8R5I2	Gene names	Tjap1, Pilt, Tjp4
Domain Architecture	No domain graphic available
Description	Tight junction-associated protein 1 (Tight junction protein 4) (Protein incorporated later into tight junctions).

TTBK1_HUMAN
NC score	0.010709 (rank : 284)	θ value	4.03905 (rank : 153)
Query Neighborhood Hits	186	Target Neighborhood Hits	1058	Shared Neighborhood Hits	34
SwissProt Accessions	Q5TCY1, Q2L6C6, Q8N444, Q96JH2	Gene names	TTBK1, BDTK, KIAA1855
Domain Architecture	No domain graphic available
Description	Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase).

CUTL2_HUMAN
NC score	0.009435 (rank : 285)	θ value	5.27518 (rank : 158)
Query Neighborhood Hits	186	Target Neighborhood Hits	906	Shared Neighborhood Hits	24
SwissProt Accessions	O14529	Gene names	CUTL2, KIAA0293
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 2 (Homeobox protein Cux-2) (Cut-like 2).

RIMS2_HUMAN
NC score	0.009124 (rank : 286)	θ value	4.03905 (rank : 151)
Query Neighborhood Hits	186	Target Neighborhood Hits	342	Shared Neighborhood Hits	16
SwissProt Accessions	Q9UQ26, O43413, Q86XL9, Q8IWV9, Q8IWW1	Gene names	RIMS2, KIAA0751, RIM2
Domain Architecture
Description	Regulating synaptic membrane exocytosis protein 2 (Rab3-interacting molecule 2) (RIM 2).

TF65_HUMAN
NC score	0.008899 (rank : 287)	θ value	4.03905 (rank : 152)
Query Neighborhood Hits	186	Target Neighborhood Hits	115	Shared Neighborhood Hits	9
SwissProt Accessions	Q04206, Q6SLK1	Gene names	RELA, NFKB3
Domain Architecture
Description	Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit).

RBNS5_HUMAN
NC score	0.008361 (rank : 288)	θ value	5.27518 (rank : 162)
Query Neighborhood Hits	186	Target Neighborhood Hits	242	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H1K0, Q3KP30, Q59EY8, Q8NAQ1	Gene names	ZFYVE20
Domain Architecture	No domain graphic available
Description	Rabenosyn-5 (FYVE finger-containing Rab5 effector protein rabenosyn-5) (Zinc finger FYVE domain-containing protein 20) (110 kDa protein).

KLC2_HUMAN
NC score	0.008305 (rank : 289)	θ value	1.81305 (rank : 124)
Query Neighborhood Hits	186	Target Neighborhood Hits	227	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H0B6, Q9H9C8, Q9HA20	Gene names	KLC2
Domain Architecture
Description	Kinesin light chain 2 (KLC 2).

ROBO4_HUMAN
NC score	0.007487 (rank : 290)	θ value	0.62314 (rank : 94)
Query Neighborhood Hits	186	Target Neighborhood Hits	364	Shared Neighborhood Hits	4
SwissProt Accessions	Q8WZ75, Q8TEG1, Q96JV6, Q9H718, Q9NWJ8	Gene names	ROBO4
Domain Architecture
Description	Roundabout homolog 4 precursor (Magic roundabout).

FOXO4_HUMAN
NC score	0.005951 (rank : 291)	θ value	2.36792 (rank : 130)
Query Neighborhood Hits	186	Target Neighborhood Hits	197	Shared Neighborhood Hits	6
SwissProt Accessions	P98177, O43821, Q13720, Q3KPF1, Q8TDK9	Gene names	MLLT7, AFX, AFX1, FOXO4
Domain Architecture
Description	Fork head domain transcription factor AFX1 (Forkhead box protein O4).

S12A6_HUMAN
NC score	0.005821 (rank : 292)	θ value	3.0926 (rank : 140)
Query Neighborhood Hits	186	Target Neighborhood Hits	58	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UHW9, Q8TDD4, Q9UFR2, Q9Y642, Q9Y665	Gene names	SLC12A6, KCC3
Domain Architecture
Description	Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3).

ZDHC8_HUMAN
NC score	0.005282 (rank : 293)	θ value	4.03905 (rank : 155)
Query Neighborhood Hits	186	Target Neighborhood Hits	234	Shared Neighborhood Hits	8
SwissProt Accessions	Q9ULC8, Q6ICL1, Q6ZNF5, Q7Z6L9	Gene names	ZDHHC8, KIAA1292, ZDHHCL1, ZNF378
Domain Architecture
Description	Probable palmitoyltransferase ZDHHC8 (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 8) (DHHC-8) (Zinc finger protein 378).

CTND1_MOUSE
NC score	0.004997 (rank : 294)	θ value	5.27518 (rank : 157)
Query Neighborhood Hits	186	Target Neighborhood Hits	69	Shared Neighborhood Hits	2
SwissProt Accessions	P30999	Gene names	Ctnnd1, Catns
Domain Architecture
Description	Catenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Src substrate) (CAS) (p120(cas)).

CT075_MOUSE
NC score	0.004450 (rank : 295)	θ value	4.03905 (rank : 144)
Query Neighborhood Hits	186	Target Neighborhood Hits	358	Shared Neighborhood Hits	8
SwissProt Accessions	P59383	Gene names
Domain Architecture
Description	Uncharacterized protein C20orf75 homolog precursor.

NPAS2_MOUSE
NC score	0.003901 (rank : 296)	θ value	8.99809 (rank : 181)
Query Neighborhood Hits	186	Target Neighborhood Hits	132	Shared Neighborhood Hits	6
SwissProt Accessions	P97460	Gene names	Npas2
Domain Architecture
Description	Neuronal PAS domain-containing protein 2 (Neuronal PAS2).

FOG1_HUMAN
NC score	0.003549 (rank : 297)	θ value	3.0926 (rank : 137)
Query Neighborhood Hits	186	Target Neighborhood Hits	981	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IX07	Gene names	ZFPM1, FOG1
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZFPM1 (Zinc finger protein multitype 1) (Friend of GATA protein 1) (Friend of GATA-1) (FOG-1).

ABCA7_HUMAN
NC score	0.000702 (rank : 298)	θ value	8.99809 (rank : 178)
Query Neighborhood Hits	186	Target Neighborhood Hits	144	Shared Neighborhood Hits	4
SwissProt Accessions	Q8IZY2, Q96S58, Q9BZC4, Q9NR73, Q9UKP8	Gene names	ABCA7
Domain Architecture	No domain graphic available
Description	ATP-binding cassette sub-family A member 7 (Macrophage ABC transporter) (Autoantigen SS-N) (ABCA-SSN).

PHLPP_MOUSE
NC score	0.000041 (rank : 299)	θ value	6.88961 (rank : 175)
Query Neighborhood Hits	186	Target Neighborhood Hits	394	Shared Neighborhood Hits	8
SwissProt Accessions	Q8CHE4, Q6PCN0, Q8QZU8, Q8R5E5, Q99KL6	Gene names	Phlpp, Kiaa0606, Plekhe1, Scop
Domain Architecture	No domain graphic available
Description	PH domain leucine-rich repeat-containing protein phosphatase (EC 3.1.3.16) (PH domain leucine-rich repeat protein phosphatase) (Pleckstrin homology domain-containing family E protein 1) (Suprachiasmatic nucleus circadian oscillatory protein).

MAST2_HUMAN
NC score	-0.000138 (rank : 300)	θ value	2.36792 (rank : 134)
Query Neighborhood Hits	186	Target Neighborhood Hits	1189	Shared Neighborhood Hits	34
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

CELR3_HUMAN
NC score	-0.000268 (rank : 301)	θ value	1.81305 (rank : 122)
Query Neighborhood Hits	186	Target Neighborhood Hits	680	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NYQ7, O75092	Gene names	CELSR3, CDHF11, EGFL1, FMI1, KIAA0812, MEGF2
Domain Architecture
Description	Cadherin EGF LAG seven-pass G-type receptor 3 precursor (Flamingo homolog 1) (hFmi1) (Multiple epidermal growth factor-like domains 2) (Epidermal growth factor-like 1).

TRI65_HUMAN
NC score	-0.000400 (rank : 302)	θ value	8.99809 (rank : 186)
Query Neighborhood Hits	186	Target Neighborhood Hits	330	Shared Neighborhood Hits	4
SwissProt Accessions	Q6PJ69, Q4G0F0, Q6DKJ6, Q9BRP6	Gene names	TRIM65
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 65.

ARBK1_HUMAN
NC score	-0.000940 (rank : 303)	θ value	4.03905 (rank : 143)
Query Neighborhood Hits	186	Target Neighborhood Hits	859	Shared Neighborhood Hits	19
SwissProt Accessions	P25098, Q13837	Gene names	ADRBK1, BARK, BARK1, GRK2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein coupled receptor kinase 2).

ARBK1_MOUSE
NC score	-0.001521 (rank : 304)	θ value	5.27518 (rank : 156)
Query Neighborhood Hits	186	Target Neighborhood Hits	849	Shared Neighborhood Hits	18
SwissProt Accessions	Q99MK8, Q99LL8	Gene names	Adrbk1, Grk2
Domain Architecture
Description	Beta-adrenergic receptor kinase 1 (EC 2.7.11.15) (Beta-ARK-1) (G- protein-coupled receptor kinase 2).

PRDM2_HUMAN
NC score	-0.002687 (rank : 305)	θ value	6.88961 (rank : 176)
Query Neighborhood Hits	186	Target Neighborhood Hits	1135	Shared Neighborhood Hits	21
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

BC11B_HUMAN
NC score	-0.003360 (rank : 306)	θ value	3.0926 (rank : 136)
Query Neighborhood Hits	186	Target Neighborhood Hits	761	Shared Neighborhood Hits	7
SwissProt Accessions	Q9C0K0, Q9H162	Gene names	BCL11B, CTIP2, RIT1
Domain Architecture	No domain graphic available
Description	B-cell lymphoma/leukemia 11B (B-cell CLL/lymphoma 11B) (Radiation- induced tumor suppressor gene 1 protein) (hRit1) (COUP-TF-interacting protein 2).

HIC2_HUMAN
NC score	-0.004135 (rank : 307)	θ value	0.813845 (rank : 101)
Query Neighborhood Hits	186	Target Neighborhood Hits	820	Shared Neighborhood Hits	8
SwissProt Accessions	Q96JB3, Q96KR3, Q9NSM9, Q9UPX9	Gene names	HIC2, HRG22, KIAA1020, ZBTB30
Domain Architecture
Description	Hypermethylated in cancer 2 protein (Hic-2) (Hic-3) (HIC1-related gene on chromosome 22) (Zinc finger and BTB domain-containing protein 30).