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Network neighborhood for query Sequence : TSC2_HUMAN

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TSC2_HUMAN
SwissProt Accessions	P49815, O75275, Q8TAZ1	Gene names	TSC2
Domain Architecture
Description	Tuberin (Tuberous sclerosis 2 protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TSC2_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	59	Target Neighborhood Hits	59	Shared Neighborhood Hits	59
SwissProt Accessions	P49815, O75275, Q8TAZ1	Gene names	TSC2
Domain Architecture
Description	Tuberin (Tuberous sclerosis 2 protein).

TSC2_MOUSE
θ value	0 (rank : 2)	NC score	0.991071 (rank : 2)
Query Neighborhood Hits	59	Target Neighborhood Hits	48	Shared Neighborhood Hits	17
SwissProt Accessions	Q61037, P97723, P97724, P97725, P97727, Q61007, Q61008, Q9WUF6	Gene names	Tsc2
Domain Architecture
Description	Tuberin (Tuberous sclerosis 2 homolog protein).

GRIPE_HUMAN
θ value	4.58923e-20 (rank : 3)	NC score	0.527405 (rank : 4)
Query Neighborhood Hits	59	Target Neighborhood Hits	69	Shared Neighborhood Hits	12
SwissProt Accessions	Q6GYQ0, O94960, Q6GYP9, Q6ZT23, Q86YF3, Q86YF5, Q8ND69	Gene names	GARNL1, KIAA0884, TULIP1
Domain Architecture	No domain graphic available
Description	GTPase-activating Rap/Ran-GAP domain-like 1 (GAP-related-interacting partner to E12) (GRIPE) (Tuberin-like protein 1).

GRIPE_MOUSE
θ value	5.99374e-20 (rank : 4)	NC score	0.524967 (rank : 5)
Query Neighborhood Hits	59	Target Neighborhood Hits	70	Shared Neighborhood Hits	12
SwissProt Accessions	Q6GYP7, Q6GYP6, Q6ZQ28, Q8BNJ5, Q8C9G8, Q8CIW4, Q9JMC4	Gene names	Garnl1, Kiaa0884, Tulip1
Domain Architecture	No domain graphic available
Description	GTPase-activating RapGAP domain-like 1 (GAP-related-interacting partner to E12) (GRIPE) (Tuberin-like protein 1).

RGP2_HUMAN
θ value	7.09661e-13 (rank : 5)	NC score	0.530450 (rank : 3)
Query Neighborhood Hits	59	Target Neighborhood Hits	60	Shared Neighborhood Hits	14
SwissProt Accessions	P47736	Gene names	RAP1GAP, RAP1GA1
Domain Architecture
Description	Rap1 GTPase-activating protein 1 (Rap1GAP).

SI1L2_HUMAN
θ value	6.64225e-11 (rank : 6)	NC score	0.436685 (rank : 8)
Query Neighborhood Hits	59	Target Neighborhood Hits	131	Shared Neighborhood Hits	13
SwissProt Accessions	Q9P2F8, Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6	Gene names	SIPA1L2, KIAA1389
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

SI1L2_MOUSE
θ value	1.47974e-10 (rank : 7)	NC score	0.436518 (rank : 9)
Query Neighborhood Hits	59	Target Neighborhood Hits	124	Shared Neighborhood Hits	13
SwissProt Accessions	Q80TE4, Q6PDY1	Gene names	Sipa1l2, Kiaa0545
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

SI1L1_HUMAN
θ value	2.52405e-10 (rank : 8)	NC score	0.432395 (rank : 10)
Query Neighborhood Hits	59	Target Neighborhood Hits	162	Shared Neighborhood Hits	14
SwissProt Accessions	O43166, O95321, Q9UDU4, Q9UNU4	Gene names	SIPA1L1, E6TP1, KIAA0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1 (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6- targeted protein 1).

SI1L1_MOUSE
θ value	2.52405e-10 (rank : 9)	NC score	0.431390 (rank : 12)
Query Neighborhood Hits	59	Target Neighborhood Hits	189	Shared Neighborhood Hits	16
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

SIPA1_HUMAN
θ value	2.52405e-10 (rank : 10)	NC score	0.440547 (rank : 7)
Query Neighborhood Hits	59	Target Neighborhood Hits	250	Shared Neighborhood Hits	15
SwissProt Accessions	Q96FS4, O14518, O60484, O60618	Gene names	SIPA1, SPA1
Domain Architecture
Description	Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase- activating protein Spa-1) (p130 SPA-1).

SI1L3_HUMAN
θ value	7.34386e-10 (rank : 11)	NC score	0.431781 (rank : 11)
Query Neighborhood Hits	59	Target Neighborhood Hits	305	Shared Neighborhood Hits	23
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

SIPA1_MOUSE
θ value	1.63604e-09 (rank : 12)	NC score	0.443297 (rank : 6)
Query Neighborhood Hits	59	Target Neighborhood Hits	158	Shared Neighborhood Hits	12
SwissProt Accessions	P46062, P70204	Gene names	Sipa1, Spa-1, Spa1
Domain Architecture
Description	Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase- activating protein Spa-1).

FANCE_HUMAN
θ value	0.125558 (rank : 13)	NC score	0.110198 (rank : 13)
Query Neighborhood Hits	59	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HB96, Q4ZGH2	Gene names	FANCE
Domain Architecture	No domain graphic available
Description	Fanconi anemia group E protein (Protein FACE).

CTDP1_MOUSE
θ value	0.365318 (rank : 14)	NC score	0.047306 (rank : 15)
Query Neighborhood Hits	59	Target Neighborhood Hits	146	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TSG2, Q7TSS7, Q9D4S8	Gene names	Ctdp1, Fcp1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

PDZD2_HUMAN
θ value	0.365318 (rank : 15)	NC score	0.025159 (rank : 21)
Query Neighborhood Hits	59	Target Neighborhood Hits	772	Shared Neighborhood Hits	12
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

LYST_MOUSE
θ value	0.62314 (rank : 16)	NC score	0.021469 (rank : 25)
Query Neighborhood Hits	59	Target Neighborhood Hits	286	Shared Neighborhood Hits	3
SwissProt Accessions	P97412, Q62403, Q8VBS6	Gene names	Lyst, Bg, Chs1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige protein) (CHS1 homolog).

GON4L_HUMAN
θ value	1.06291 (rank : 17)	NC score	0.025414 (rank : 20)
Query Neighborhood Hits	59	Target Neighborhood Hits	555	Shared Neighborhood Hits	6
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

PCLO_HUMAN
θ value	1.38821 (rank : 18)	NC score	0.017846 (rank : 34)
Query Neighborhood Hits	59	Target Neighborhood Hits	2046	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

COA1_HUMAN
θ value	1.81305 (rank : 19)	NC score	0.019614 (rank : 29)
Query Neighborhood Hits	59	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q13085	Gene names	ACACA, ACAC, ACC1, ACCA
Domain Architecture
Description	Acetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)].

CSKI1_HUMAN
θ value	1.81305 (rank : 20)	NC score	0.008199 (rank : 50)
Query Neighborhood Hits	59	Target Neighborhood Hits	997	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

TLN1_HUMAN
θ value	1.81305 (rank : 21)	NC score	0.027648 (rank : 18)
Query Neighborhood Hits	59	Target Neighborhood Hits	218	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

TLN1_MOUSE
θ value	1.81305 (rank : 22)	NC score	0.029150 (rank : 17)
Query Neighborhood Hits	59	Target Neighborhood Hits	213	Shared Neighborhood Hits	9
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

BSN_MOUSE
θ value	3.0926 (rank : 23)	NC score	0.018864 (rank : 31)
Query Neighborhood Hits	59	Target Neighborhood Hits	2057	Shared Neighborhood Hits	21
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

RHG09_HUMAN
θ value	3.0926 (rank : 24)	NC score	0.012037 (rank : 46)
Query Neighborhood Hits	59	Target Neighborhood Hits	186	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

STON2_MOUSE
θ value	3.0926 (rank : 25)	NC score	0.017482 (rank : 35)
Query Neighborhood Hits	59	Target Neighborhood Hits	75	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BZ60	Gene names	Ston2, Stn2, Stnb
Domain Architecture
Description	Stonin-2 (Stoned B).

DKC1_MOUSE
θ value	4.03905 (rank : 26)	NC score	0.021037 (rank : 26)
Query Neighborhood Hits	59	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ESX5	Gene names	Dkc1
Domain Architecture	No domain graphic available
Description	H/ACA ribonucleoprotein complex subunit 4 (EC 5.4.99.-) (Dyskerin) (Nucleolar protein family A member 4) (snoRNP protein DKC1) (Nopp140- associated protein of 57 kDa) (Nucleolar protein NAP57).

GP158_MOUSE
θ value	4.03905 (rank : 27)	NC score	0.022958 (rank : 23)
Query Neighborhood Hits	59	Target Neighborhood Hits	82	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C419, Q8CHB0	Gene names	Gpr158, Kiaa1136
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 158 precursor.

MMS19_HUMAN
θ value	4.03905 (rank : 28)	NC score	0.019464 (rank : 30)
Query Neighborhood Hits	59	Target Neighborhood Hits	21	Shared Neighborhood Hits	2
SwissProt Accessions	Q96T76, Q5T455, Q66K82, Q7L4W8, Q969Z1, Q96DF1, Q96MR1, Q96RK5, Q96SK1, Q9BUE2, Q9BYS9	Gene names	MMS19L, MMS19
Domain Architecture	No domain graphic available
Description	MMS19-like protein (hMMS19) (MET18 homolog).

REXO1_HUMAN
θ value	4.03905 (rank : 29)	NC score	0.016770 (rank : 37)
Query Neighborhood Hits	59	Target Neighborhood Hits	242	Shared Neighborhood Hits	8
SwissProt Accessions	Q8N1G1, Q9ULT2	Gene names	REXO1, ELOABP1, KIAA1138, TCEB3BP1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1).

STK23_HUMAN
θ value	4.03905 (rank : 30)	NC score	0.017882 (rank : 33)
Query Neighborhood Hits	59	Target Neighborhood Hits	556	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UPE1, Q13583, Q9UM62	Gene names	STK23, MSSK1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

STK23_MOUSE
θ value	4.03905 (rank : 31)	NC score	0.025891 (rank : 19)
Query Neighborhood Hits	59	Target Neighborhood Hits	572	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Z0G2	Gene names	Stk23, Mssk1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

CD5R1_HUMAN
θ value	5.27518 (rank : 32)	NC score	0.022903 (rank : 24)
Query Neighborhood Hits	59	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q15078	Gene names	CDK5R1, CDK5R, NCK5A
Domain Architecture
Description	Cyclin-dependent kinase 5 activator 1 precursor (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (Tau protein kinase II 23 kDa subunit) (TPKII regulatory subunit) (p23) (p25) (p35) [Contains: Cyclin-dependent kinase 5 activator 1, p35; Cyclin- dependent kinase 5 activator 1, p25].

GP158_HUMAN
θ value	5.27518 (rank : 33)	NC score	0.020853 (rank : 27)
Query Neighborhood Hits	59	Target Neighborhood Hits	221	Shared Neighborhood Hits	6
SwissProt Accessions	Q5T848, Q6QR81, Q9ULT3	Gene names	GPR158, KIAA1136
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 158 precursor.

TXD11_HUMAN
θ value	5.27518 (rank : 34)	NC score	0.012471 (rank : 45)
Query Neighborhood Hits	59	Target Neighborhood Hits	402	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PKC3, O95887, Q6PJA6, Q8N2Q4, Q96K45, Q96K53	Gene names	TXNDC11, EFP1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 11 (EF-hand-binding protein 1).

ABL1_MOUSE
θ value	6.88961 (rank : 35)	NC score	-0.000201 (rank : 58)
Query Neighborhood Hits	59	Target Neighborhood Hits	1178	Shared Neighborhood Hits	6
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ACAD9_HUMAN
θ value	6.88961 (rank : 36)	NC score	0.007622 (rank : 51)
Query Neighborhood Hits	59	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H845, Q8WXX3	Gene names	ACAD9
Domain Architecture
Description	Acyl-CoA dehydrogenase family member 9, mitochondrial precursor (EC 1.3.99.-) (ACAD-9).

CD5R1_MOUSE
θ value	6.88961 (rank : 37)	NC score	0.020553 (rank : 28)
Query Neighborhood Hits	59	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	P61809, Q62938	Gene names	Cdk5r1, Cdk5r, Nck5a
Domain Architecture
Description	Cyclin-dependent kinase 5 activator 1 precursor (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (Tau protein kinase II 23 kDa subunit) (TPKII regulatory subunit) (p23) (p25) (p35) [Contains: Cyclin-dependent kinase 5 activator 1, p35; Cyclin- dependent kinase 5 activator 1, p25].

CJ067_HUMAN
θ value	6.88961 (rank : 38)	NC score	0.050876 (rank : 14)
Query Neighborhood Hits	59	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IYJ2, Q5SWD4	Gene names	C10orf67
Domain Architecture	No domain graphic available
Description	Protein C10orf67.

NRTN_MOUSE
θ value	6.88961 (rank : 39)	NC score	0.016323 (rank : 38)
Query Neighborhood Hits	59	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	P97463	Gene names	Nrtn
Domain Architecture
Description	Neurturin precursor.

PHLB1_MOUSE
θ value	6.88961 (rank : 40)	NC score	0.010532 (rank : 48)
Query Neighborhood Hits	59	Target Neighborhood Hits	678	Shared Neighborhood Hits	12
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

SRPK1_HUMAN
θ value	6.88961 (rank : 41)	NC score	0.015691 (rank : 39)
Query Neighborhood Hits	59	Target Neighborhood Hits	706	Shared Neighborhood Hits	9
SwissProt Accessions	Q96SB4, Q12890, Q5R364, Q5R365, Q8IY12	Gene names	SRPK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

SRPK2_MOUSE
θ value	6.88961 (rank : 42)	NC score	0.015524 (rank : 40)
Query Neighborhood Hits	59	Target Neighborhood Hits	765	Shared Neighborhood Hits	8
SwissProt Accessions	O54781, Q8VCD9	Gene names	Srpk2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

TCOF_HUMAN
θ value	6.88961 (rank : 43)	NC score	0.016893 (rank : 36)
Query Neighborhood Hits	59	Target Neighborhood Hits	543	Shared Neighborhood Hits	12
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

TEC_MOUSE
θ value	6.88961 (rank : 44)	NC score	-0.000302 (rank : 59)
Query Neighborhood Hits	59	Target Neighborhood Hits	1006	Shared Neighborhood Hits	3
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

TLN2_HUMAN
θ value	6.88961 (rank : 45)	NC score	0.024653 (rank : 22)
Query Neighborhood Hits	59	Target Neighborhood Hits	157	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y4G6	Gene names	TLN2, KIAA0320
Domain Architecture
Description	Talin-2.

TM131_MOUSE
θ value	6.88961 (rank : 46)	NC score	0.018088 (rank : 32)
Query Neighborhood Hits	59	Target Neighborhood Hits	156	Shared Neighborhood Hits	5
SwissProt Accessions	O70472	Gene names	Tmem131, D1Bwg0491e, Rw1
Domain Architecture	No domain graphic available
Description	Transmembrane protein 131 (Protein RW1).

ZN598_MOUSE
θ value	6.88961 (rank : 47)	NC score	0.013654 (rank : 44)
Query Neighborhood Hits	59	Target Neighborhood Hits	255	Shared Neighborhood Hits	4
SwissProt Accessions	Q80YR4, Q6KAT0, Q8R3S1	Gene names	Znf598, Zfp598
Domain Architecture	No domain graphic available
Description	Zinc finger protein 598.

ANR25_HUMAN
θ value	8.99809 (rank : 48)	NC score	0.006656 (rank : 52)
Query Neighborhood Hits	59	Target Neighborhood Hits	350	Shared Neighborhood Hits	5
SwissProt Accessions	Q63ZY3, Q3KQZ3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210	Gene names	ANKRD25, KIAA1518, SIP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25 (SRC-1-interacting protein) (SRC1-interacting protein).

BCLF1_HUMAN
θ value	8.99809 (rank : 49)	NC score	0.010968 (rank : 47)
Query Neighborhood Hits	59	Target Neighborhood Hits	298	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NYF8, Q14673, Q86WU6, Q86WY0	Gene names	BCLAF1, BTF, KIAA0164
Domain Architecture	No domain graphic available
Description	Bcl-2-associated transcription factor 1 (Btf).

DOT1L_HUMAN
θ value	8.99809 (rank : 50)	NC score	0.014340 (rank : 43)
Query Neighborhood Hits	59	Target Neighborhood Hits	660	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

FGF4_HUMAN
θ value	8.99809 (rank : 51)	NC score	0.006160 (rank : 53)
Query Neighborhood Hits	59	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	P08620	Gene names	FGF4, HST, HSTF1, KS3
Domain Architecture
Description	Fibroblast growth factor 4 precursor (FGF-4) (Heparin secretory- transforming protein) (HST-1) (HST) (Transforming protein KS3) (HBGF- 4).

KCNQ1_HUMAN
θ value	8.99809 (rank : 52)	NC score	0.005551 (rank : 56)
Query Neighborhood Hits	59	Target Neighborhood Hits	99	Shared Neighborhood Hits	3
SwissProt Accessions	P51787, O00347, O60607, O94787, Q7Z6G9, Q92960, Q9UMN8, Q9UMN9	Gene names	KCNQ1, KCNA8, KCNA9, KVLQT1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

LLR1_HUMAN
θ value	8.99809 (rank : 53)	NC score	0.005732 (rank : 55)
Query Neighborhood Hits	59	Target Neighborhood Hits	225	Shared Neighborhood Hits	3
SwissProt Accessions	Q96L50, Q86SZ1, Q8N6H9	Gene names	PPIL5, LRR1
Domain Architecture
Description	Peptidylprolyl isomerase-like 5 (LRR-repeat protein 1) (LRR-1) (4-1BB- mediated signaling molecule) (4-1BBlrr).

LRC50_HUMAN
θ value	8.99809 (rank : 54)	NC score	0.008962 (rank : 49)
Query Neighborhood Hits	59	Target Neighborhood Hits	275	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NEP3, Q69YI8, Q69YJ0, Q96LP3	Gene names	LRRC50
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 50.

LUZP1_MOUSE
θ value	8.99809 (rank : 55)	NC score	0.006149 (rank : 54)
Query Neighborhood Hits	59	Target Neighborhood Hits	940	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

PEX6_MOUSE
θ value	8.99809 (rank : 56)	NC score	0.004558 (rank : 57)
Query Neighborhood Hits	59	Target Neighborhood Hits	94	Shared Neighborhood Hits	2
SwissProt Accessions	Q99LC9, Q6YNQ9	Gene names	Pex6
Domain Architecture	No domain graphic available
Description	Peroxisome assembly factor 2 (PAF-2) (Peroxisomal-type ATPase 1) (Peroxin-6) (Peroxisomal biogenesis factor 6).

SHAN2_HUMAN
θ value	8.99809 (rank : 57)	NC score	0.034394 (rank : 16)
Query Neighborhood Hits	59	Target Neighborhood Hits	346	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

SRPK1_MOUSE
θ value	8.99809 (rank : 58)	NC score	0.014625 (rank : 42)
Query Neighborhood Hits	59	Target Neighborhood Hits	639	Shared Neighborhood Hits	8
SwissProt Accessions	O70551, O70193, Q99JT3	Gene names	Srpk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

SRPK2_HUMAN
θ value	8.99809 (rank : 59)	NC score	0.015245 (rank : 41)
Query Neighborhood Hits	59	Target Neighborhood Hits	664	Shared Neighborhood Hits	8
SwissProt Accessions	P78362, O75220, O75221, Q6NUL0, Q6V1X2, Q8IYQ3	Gene names	SRPK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

Hits sorted by NC score

TSC2_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	59	Target Neighborhood Hits	59	Shared Neighborhood Hits	59
SwissProt Accessions	P49815, O75275, Q8TAZ1	Gene names	TSC2
Domain Architecture
Description	Tuberin (Tuberous sclerosis 2 protein).

TSC2_MOUSE
NC score	0.991071 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	59	Target Neighborhood Hits	48	Shared Neighborhood Hits	17
SwissProt Accessions	Q61037, P97723, P97724, P97725, P97727, Q61007, Q61008, Q9WUF6	Gene names	Tsc2
Domain Architecture
Description	Tuberin (Tuberous sclerosis 2 homolog protein).

RGP2_HUMAN
NC score	0.530450 (rank : 3)	θ value	7.09661e-13 (rank : 5)
Query Neighborhood Hits	59	Target Neighborhood Hits	60	Shared Neighborhood Hits	14
SwissProt Accessions	P47736	Gene names	RAP1GAP, RAP1GA1
Domain Architecture
Description	Rap1 GTPase-activating protein 1 (Rap1GAP).

GRIPE_HUMAN
NC score	0.527405 (rank : 4)	θ value	4.58923e-20 (rank : 3)
Query Neighborhood Hits	59	Target Neighborhood Hits	69	Shared Neighborhood Hits	12
SwissProt Accessions	Q6GYQ0, O94960, Q6GYP9, Q6ZT23, Q86YF3, Q86YF5, Q8ND69	Gene names	GARNL1, KIAA0884, TULIP1
Domain Architecture	No domain graphic available
Description	GTPase-activating Rap/Ran-GAP domain-like 1 (GAP-related-interacting partner to E12) (GRIPE) (Tuberin-like protein 1).

GRIPE_MOUSE
NC score	0.524967 (rank : 5)	θ value	5.99374e-20 (rank : 4)
Query Neighborhood Hits	59	Target Neighborhood Hits	70	Shared Neighborhood Hits	12
SwissProt Accessions	Q6GYP7, Q6GYP6, Q6ZQ28, Q8BNJ5, Q8C9G8, Q8CIW4, Q9JMC4	Gene names	Garnl1, Kiaa0884, Tulip1
Domain Architecture	No domain graphic available
Description	GTPase-activating RapGAP domain-like 1 (GAP-related-interacting partner to E12) (GRIPE) (Tuberin-like protein 1).

SIPA1_MOUSE
NC score	0.443297 (rank : 6)	θ value	1.63604e-09 (rank : 12)
Query Neighborhood Hits	59	Target Neighborhood Hits	158	Shared Neighborhood Hits	12
SwissProt Accessions	P46062, P70204	Gene names	Sipa1, Spa-1, Spa1
Domain Architecture
Description	Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase- activating protein Spa-1).

SIPA1_HUMAN
NC score	0.440547 (rank : 7)	θ value	2.52405e-10 (rank : 10)
Query Neighborhood Hits	59	Target Neighborhood Hits	250	Shared Neighborhood Hits	15
SwissProt Accessions	Q96FS4, O14518, O60484, O60618	Gene names	SIPA1, SPA1
Domain Architecture
Description	Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase- activating protein Spa-1) (p130 SPA-1).

SI1L2_HUMAN
NC score	0.436685 (rank : 8)	θ value	6.64225e-11 (rank : 6)
Query Neighborhood Hits	59	Target Neighborhood Hits	131	Shared Neighborhood Hits	13
SwissProt Accessions	Q9P2F8, Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6	Gene names	SIPA1L2, KIAA1389
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

SI1L2_MOUSE
NC score	0.436518 (rank : 9)	θ value	1.47974e-10 (rank : 7)
Query Neighborhood Hits	59	Target Neighborhood Hits	124	Shared Neighborhood Hits	13
SwissProt Accessions	Q80TE4, Q6PDY1	Gene names	Sipa1l2, Kiaa0545
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

SI1L1_HUMAN
NC score	0.432395 (rank : 10)	θ value	2.52405e-10 (rank : 8)
Query Neighborhood Hits	59	Target Neighborhood Hits	162	Shared Neighborhood Hits	14
SwissProt Accessions	O43166, O95321, Q9UDU4, Q9UNU4	Gene names	SIPA1L1, E6TP1, KIAA0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1 (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6- targeted protein 1).

SI1L3_HUMAN
NC score	0.431781 (rank : 11)	θ value	7.34386e-10 (rank : 11)
Query Neighborhood Hits	59	Target Neighborhood Hits	305	Shared Neighborhood Hits	23
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

SI1L1_MOUSE
NC score	0.431390 (rank : 12)	θ value	2.52405e-10 (rank : 9)
Query Neighborhood Hits	59	Target Neighborhood Hits	189	Shared Neighborhood Hits	16
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

FANCE_HUMAN
NC score	0.110198 (rank : 13)	θ value	0.125558 (rank : 13)
Query Neighborhood Hits	59	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HB96, Q4ZGH2	Gene names	FANCE
Domain Architecture	No domain graphic available
Description	Fanconi anemia group E protein (Protein FACE).

CJ067_HUMAN
NC score	0.050876 (rank : 14)	θ value	6.88961 (rank : 38)
Query Neighborhood Hits	59	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IYJ2, Q5SWD4	Gene names	C10orf67
Domain Architecture	No domain graphic available
Description	Protein C10orf67.

CTDP1_MOUSE
NC score	0.047306 (rank : 15)	θ value	0.365318 (rank : 14)
Query Neighborhood Hits	59	Target Neighborhood Hits	146	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TSG2, Q7TSS7, Q9D4S8	Gene names	Ctdp1, Fcp1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

SHAN2_HUMAN
NC score	0.034394 (rank : 16)	θ value	8.99809 (rank : 57)
Query Neighborhood Hits	59	Target Neighborhood Hits	346	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UPX8, Q3Y8G9, Q52LK2, Q9UKP1	Gene names	SHANK2, KIAA1022
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2).

TLN1_MOUSE
NC score	0.029150 (rank : 17)	θ value	1.81305 (rank : 22)
Query Neighborhood Hits	59	Target Neighborhood Hits	213	Shared Neighborhood Hits	9
SwissProt Accessions	P26039, Q8VEF0	Gene names	Tln1, Tln
Domain Architecture
Description	Talin-1.

TLN1_HUMAN
NC score	0.027648 (rank : 18)	θ value	1.81305 (rank : 21)
Query Neighborhood Hits	59	Target Neighborhood Hits	218	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y490, Q86YD0, Q9NZQ2, Q9UHH8, Q9UPX3	Gene names	TLN1, KIAA1027, TLN
Domain Architecture
Description	Talin-1.

STK23_MOUSE
NC score	0.025891 (rank : 19)	θ value	4.03905 (rank : 31)
Query Neighborhood Hits	59	Target Neighborhood Hits	572	Shared Neighborhood Hits	8
SwissProt Accessions	Q9Z0G2	Gene names	Stk23, Mssk1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

GON4L_HUMAN
NC score	0.025414 (rank : 20)	θ value	1.06291 (rank : 17)
Query Neighborhood Hits	59	Target Neighborhood Hits	555	Shared Neighborhood Hits	6
SwissProt Accessions	Q3T8J9, Q3T8J8, Q5VYZ5, Q5W0D5, Q6AWA6, Q6P1Q6, Q7Z3L3, Q8IY79, Q9BQI1, Q9HCG6	Gene names	GON4L, GON4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

PDZD2_HUMAN
NC score	0.025159 (rank : 21)	θ value	0.365318 (rank : 15)
Query Neighborhood Hits	59	Target Neighborhood Hits	772	Shared Neighborhood Hits	12
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

TLN2_HUMAN
NC score	0.024653 (rank : 22)	θ value	6.88961 (rank : 45)
Query Neighborhood Hits	59	Target Neighborhood Hits	157	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y4G6	Gene names	TLN2, KIAA0320
Domain Architecture
Description	Talin-2.

GP158_MOUSE
NC score	0.022958 (rank : 23)	θ value	4.03905 (rank : 27)
Query Neighborhood Hits	59	Target Neighborhood Hits	82	Shared Neighborhood Hits	4
SwissProt Accessions	Q8C419, Q8CHB0	Gene names	Gpr158, Kiaa1136
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 158 precursor.

CD5R1_HUMAN
NC score	0.022903 (rank : 24)	θ value	5.27518 (rank : 32)
Query Neighborhood Hits	59	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q15078	Gene names	CDK5R1, CDK5R, NCK5A
Domain Architecture
Description	Cyclin-dependent kinase 5 activator 1 precursor (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (Tau protein kinase II 23 kDa subunit) (TPKII regulatory subunit) (p23) (p25) (p35) [Contains: Cyclin-dependent kinase 5 activator 1, p35; Cyclin- dependent kinase 5 activator 1, p25].

LYST_MOUSE
NC score	0.021469 (rank : 25)	θ value	0.62314 (rank : 16)
Query Neighborhood Hits	59	Target Neighborhood Hits	286	Shared Neighborhood Hits	3
SwissProt Accessions	P97412, Q62403, Q8VBS6	Gene names	Lyst, Bg, Chs1
Domain Architecture
Description	Lysosomal-trafficking regulator (Beige protein) (CHS1 homolog).

DKC1_MOUSE
NC score	0.021037 (rank : 26)	θ value	4.03905 (rank : 26)
Query Neighborhood Hits	59	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ESX5	Gene names	Dkc1
Domain Architecture	No domain graphic available
Description	H/ACA ribonucleoprotein complex subunit 4 (EC 5.4.99.-) (Dyskerin) (Nucleolar protein family A member 4) (snoRNP protein DKC1) (Nopp140- associated protein of 57 kDa) (Nucleolar protein NAP57).

GP158_HUMAN
NC score	0.020853 (rank : 27)	θ value	5.27518 (rank : 33)
Query Neighborhood Hits	59	Target Neighborhood Hits	221	Shared Neighborhood Hits	6
SwissProt Accessions	Q5T848, Q6QR81, Q9ULT3	Gene names	GPR158, KIAA1136
Domain Architecture	No domain graphic available
Description	Probable G-protein coupled receptor 158 precursor.

CD5R1_MOUSE
NC score	0.020553 (rank : 28)	θ value	6.88961 (rank : 37)
Query Neighborhood Hits	59	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	P61809, Q62938	Gene names	Cdk5r1, Cdk5r, Nck5a
Domain Architecture
Description	Cyclin-dependent kinase 5 activator 1 precursor (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (Tau protein kinase II 23 kDa subunit) (TPKII regulatory subunit) (p23) (p25) (p35) [Contains: Cyclin-dependent kinase 5 activator 1, p35; Cyclin- dependent kinase 5 activator 1, p25].

COA1_HUMAN
NC score	0.019614 (rank : 29)	θ value	1.81305 (rank : 19)
Query Neighborhood Hits	59	Target Neighborhood Hits	49	Shared Neighborhood Hits	3
SwissProt Accessions	Q13085	Gene names	ACACA, ACAC, ACC1, ACCA
Domain Architecture
Description	Acetyl-CoA carboxylase 1 (EC 6.4.1.2) (ACC-alpha) [Includes: Biotin carboxylase (EC 6.3.4.14)].

MMS19_HUMAN
NC score	0.019464 (rank : 30)	θ value	4.03905 (rank : 28)
Query Neighborhood Hits	59	Target Neighborhood Hits	21	Shared Neighborhood Hits	2
SwissProt Accessions	Q96T76, Q5T455, Q66K82, Q7L4W8, Q969Z1, Q96DF1, Q96MR1, Q96RK5, Q96SK1, Q9BUE2, Q9BYS9	Gene names	MMS19L, MMS19
Domain Architecture	No domain graphic available
Description	MMS19-like protein (hMMS19) (MET18 homolog).

BSN_MOUSE
NC score	0.018864 (rank : 31)	θ value	3.0926 (rank : 23)
Query Neighborhood Hits	59	Target Neighborhood Hits	2057	Shared Neighborhood Hits	21
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

TM131_MOUSE
NC score	0.018088 (rank : 32)	θ value	6.88961 (rank : 46)
Query Neighborhood Hits	59	Target Neighborhood Hits	156	Shared Neighborhood Hits	5
SwissProt Accessions	O70472	Gene names	Tmem131, D1Bwg0491e, Rw1
Domain Architecture	No domain graphic available
Description	Transmembrane protein 131 (Protein RW1).

STK23_HUMAN
NC score	0.017882 (rank : 33)	θ value	4.03905 (rank : 30)
Query Neighborhood Hits	59	Target Neighborhood Hits	556	Shared Neighborhood Hits	7
SwissProt Accessions	Q9UPE1, Q13583, Q9UM62	Gene names	STK23, MSSK1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

PCLO_HUMAN
NC score	0.017846 (rank : 34)	θ value	1.38821 (rank : 18)
Query Neighborhood Hits	59	Target Neighborhood Hits	2046	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

STON2_MOUSE
NC score	0.017482 (rank : 35)	θ value	3.0926 (rank : 25)
Query Neighborhood Hits	59	Target Neighborhood Hits	75	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BZ60	Gene names	Ston2, Stn2, Stnb
Domain Architecture
Description	Stonin-2 (Stoned B).

TCOF_HUMAN
NC score	0.016893 (rank : 36)	θ value	6.88961 (rank : 43)
Query Neighborhood Hits	59	Target Neighborhood Hits	543	Shared Neighborhood Hits	12
SwissProt Accessions	Q13428, Q99408, Q99860	Gene names	TCOF1
Domain Architecture
Description	Treacle protein (Treacher Collins syndrome protein).

REXO1_HUMAN
NC score	0.016770 (rank : 37)	θ value	4.03905 (rank : 29)
Query Neighborhood Hits	59	Target Neighborhood Hits	242	Shared Neighborhood Hits	8
SwissProt Accessions	Q8N1G1, Q9ULT2	Gene names	REXO1, ELOABP1, KIAA1138, TCEB3BP1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1).

NRTN_MOUSE
NC score	0.016323 (rank : 38)	θ value	6.88961 (rank : 39)
Query Neighborhood Hits	59	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	P97463	Gene names	Nrtn
Domain Architecture
Description	Neurturin precursor.

SRPK1_HUMAN
NC score	0.015691 (rank : 39)	θ value	6.88961 (rank : 41)
Query Neighborhood Hits	59	Target Neighborhood Hits	706	Shared Neighborhood Hits	9
SwissProt Accessions	Q96SB4, Q12890, Q5R364, Q5R365, Q8IY12	Gene names	SRPK1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

SRPK2_MOUSE
NC score	0.015524 (rank : 40)	θ value	6.88961 (rank : 42)
Query Neighborhood Hits	59	Target Neighborhood Hits	765	Shared Neighborhood Hits	8
SwissProt Accessions	O54781, Q8VCD9	Gene names	Srpk2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

SRPK2_HUMAN
NC score	0.015245 (rank : 41)	θ value	8.99809 (rank : 59)
Query Neighborhood Hits	59	Target Neighborhood Hits	664	Shared Neighborhood Hits	8
SwissProt Accessions	P78362, O75220, O75221, Q6NUL0, Q6V1X2, Q8IYQ3	Gene names	SRPK2
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK2 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 2) (SR-protein-specific kinase 2) (SFRS protein kinase 2).

SRPK1_MOUSE
NC score	0.014625 (rank : 42)	θ value	8.99809 (rank : 58)
Query Neighborhood Hits	59	Target Neighborhood Hits	639	Shared Neighborhood Hits	8
SwissProt Accessions	O70551, O70193, Q99JT3	Gene names	Srpk1
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase SRPK1 (EC 2.7.11.1) (Serine/arginine- rich protein-specific kinase 1) (SR-protein-specific kinase 1) (SFRS protein kinase 1).

DOT1L_HUMAN
NC score	0.014340 (rank : 43)	θ value	8.99809 (rank : 50)
Query Neighborhood Hits	59	Target Neighborhood Hits	660	Shared Neighborhood Hits	11
SwissProt Accessions	Q8TEK3, O60379, Q96JL1	Gene names	DOT1L, KIAA1814
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-79 specific (EC 2.1.1.43) (Histone H3-K79 methyltransferase) (H3-K79-HMTase) (DOT1-like protein).

ZN598_MOUSE
NC score	0.013654 (rank : 44)	θ value	6.88961 (rank : 47)
Query Neighborhood Hits	59	Target Neighborhood Hits	255	Shared Neighborhood Hits	4
SwissProt Accessions	Q80YR4, Q6KAT0, Q8R3S1	Gene names	Znf598, Zfp598
Domain Architecture	No domain graphic available
Description	Zinc finger protein 598.

TXD11_HUMAN
NC score	0.012471 (rank : 45)	θ value	5.27518 (rank : 34)
Query Neighborhood Hits	59	Target Neighborhood Hits	402	Shared Neighborhood Hits	2
SwissProt Accessions	Q6PKC3, O95887, Q6PJA6, Q8N2Q4, Q96K45, Q96K53	Gene names	TXNDC11, EFP1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 11 (EF-hand-binding protein 1).

RHG09_HUMAN
NC score	0.012037 (rank : 46)	θ value	3.0926 (rank : 24)
Query Neighborhood Hits	59	Target Neighborhood Hits	186	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BRR9, Q8TCJ3, Q8WYR0, Q96EZ2, Q96S74	Gene names	ARHGAP9
Domain Architecture
Description	Rho-GTPase-activating protein 9.

BCLF1_HUMAN
NC score	0.010968 (rank : 47)	θ value	8.99809 (rank : 49)
Query Neighborhood Hits	59	Target Neighborhood Hits	298	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NYF8, Q14673, Q86WU6, Q86WY0	Gene names	BCLAF1, BTF, KIAA0164
Domain Architecture	No domain graphic available
Description	Bcl-2-associated transcription factor 1 (Btf).

PHLB1_MOUSE
NC score	0.010532 (rank : 48)	θ value	6.88961 (rank : 40)
Query Neighborhood Hits	59	Target Neighborhood Hits	678	Shared Neighborhood Hits	12
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

LRC50_HUMAN
NC score	0.008962 (rank : 49)	θ value	8.99809 (rank : 54)
Query Neighborhood Hits	59	Target Neighborhood Hits	275	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NEP3, Q69YI8, Q69YJ0, Q96LP3	Gene names	LRRC50
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 50.

CSKI1_HUMAN
NC score	0.008199 (rank : 50)	θ value	1.81305 (rank : 20)
Query Neighborhood Hits	59	Target Neighborhood Hits	997	Shared Neighborhood Hits	9
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

ACAD9_HUMAN
NC score	0.007622 (rank : 51)	θ value	6.88961 (rank : 36)
Query Neighborhood Hits	59	Target Neighborhood Hits	28	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H845, Q8WXX3	Gene names	ACAD9
Domain Architecture
Description	Acyl-CoA dehydrogenase family member 9, mitochondrial precursor (EC 1.3.99.-) (ACAD-9).

ANR25_HUMAN
NC score	0.006656 (rank : 52)	θ value	8.99809 (rank : 48)
Query Neighborhood Hits	59	Target Neighborhood Hits	350	Shared Neighborhood Hits	5
SwissProt Accessions	Q63ZY3, Q3KQZ3, Q6GUF5, Q9H8S4, Q9NUP0, Q9P210	Gene names	ANKRD25, KIAA1518, SIP
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 25 (SRC-1-interacting protein) (SRC1-interacting protein).

FGF4_HUMAN
NC score	0.006160 (rank : 53)	θ value	8.99809 (rank : 51)
Query Neighborhood Hits	59	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	P08620	Gene names	FGF4, HST, HSTF1, KS3
Domain Architecture
Description	Fibroblast growth factor 4 precursor (FGF-4) (Heparin secretory- transforming protein) (HST-1) (HST) (Transforming protein KS3) (HBGF- 4).

LUZP1_MOUSE
NC score	0.006149 (rank : 54)	θ value	8.99809 (rank : 55)
Query Neighborhood Hits	59	Target Neighborhood Hits	940	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

LLR1_HUMAN
NC score	0.005732 (rank : 55)	θ value	8.99809 (rank : 53)
Query Neighborhood Hits	59	Target Neighborhood Hits	225	Shared Neighborhood Hits	3
SwissProt Accessions	Q96L50, Q86SZ1, Q8N6H9	Gene names	PPIL5, LRR1
Domain Architecture
Description	Peptidylprolyl isomerase-like 5 (LRR-repeat protein 1) (LRR-1) (4-1BB- mediated signaling molecule) (4-1BBlrr).

KCNQ1_HUMAN
NC score	0.005551 (rank : 56)	θ value	8.99809 (rank : 52)
Query Neighborhood Hits	59	Target Neighborhood Hits	99	Shared Neighborhood Hits	3
SwissProt Accessions	P51787, O00347, O60607, O94787, Q7Z6G9, Q92960, Q9UMN8, Q9UMN9	Gene names	KCNQ1, KCNA8, KCNA9, KVLQT1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

PEX6_MOUSE
NC score	0.004558 (rank : 57)	θ value	8.99809 (rank : 56)
Query Neighborhood Hits	59	Target Neighborhood Hits	94	Shared Neighborhood Hits	2
SwissProt Accessions	Q99LC9, Q6YNQ9	Gene names	Pex6
Domain Architecture	No domain graphic available
Description	Peroxisome assembly factor 2 (PAF-2) (Peroxisomal-type ATPase 1) (Peroxin-6) (Peroxisomal biogenesis factor 6).

ABL1_MOUSE
NC score	-0.000201 (rank : 58)	θ value	6.88961 (rank : 35)
Query Neighborhood Hits	59	Target Neighborhood Hits	1178	Shared Neighborhood Hits	6
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

TEC_MOUSE
NC score	-0.000302 (rank : 59)	θ value	6.88961 (rank : 44)
Query Neighborhood Hits	59	Target Neighborhood Hits	1006	Shared Neighborhood Hits	3
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).