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Network neighborhood for query Sequence : PEX6_MOUSE

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PEX6_MOUSE
SwissProt Accessions	Q99LC9, Q6YNQ9	Gene names	Pex6
Domain Architecture	No domain graphic available
Description	Peroxisome assembly factor 2 (PAF-2) (Peroxisomal-type ATPase 1) (Peroxin-6) (Peroxisomal biogenesis factor 6).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PEX6_HUMAN
θ value	0 (rank : 1)	NC score	0.998215 (rank : 2)
Query Neighborhood Hits	94	Target Neighborhood Hits	99	Shared Neighborhood Hits	77
SwissProt Accessions	Q13608, Q8WYQ2, Q99476	Gene names	PEX6, PXAAA1
Domain Architecture
Description	Peroxisome assembly factor 2 (PAF-2) (Peroxisomal-type ATPase 1) (Peroxin-6) (Peroxisomal biogenesis factor 6).

PEX6_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	94	Target Neighborhood Hits	94	Shared Neighborhood Hits	94
SwissProt Accessions	Q99LC9, Q6YNQ9	Gene names	Pex6
Domain Architecture	No domain graphic available
Description	Peroxisome assembly factor 2 (PAF-2) (Peroxisomal-type ATPase 1) (Peroxin-6) (Peroxisomal biogenesis factor 6).

NVL_MOUSE
θ value	1.8332e-77 (rank : 3)	NC score	0.960453 (rank : 5)
Query Neighborhood Hits	94	Target Neighborhood Hits	110	Shared Neighborhood Hits	70
SwissProt Accessions	Q9DBY8, Q3USC4, Q8BW27, Q8K2B5	Gene names	Nvl
Domain Architecture
Description	Nuclear valosin-containing protein-like (Nuclear VCP-like protein) (NVLp).

NVL_HUMAN
θ value	1.18825e-76 (rank : 4)	NC score	0.959120 (rank : 6)
Query Neighborhood Hits	94	Target Neighborhood Hits	112	Shared Neighborhood Hits	71
SwissProt Accessions	O15381, Q96EM7	Gene names	NVL
Domain Architecture
Description	Nuclear valosin-containing protein-like (Nuclear VCP-like protein) (NVLp).

TERA_HUMAN
θ value	1.89707e-74 (rank : 5)	NC score	0.961074 (rank : 3)
Query Neighborhood Hits	94	Target Neighborhood Hits	76	Shared Neighborhood Hits	67
SwissProt Accessions	P55072, Q969G7	Gene names	VCP
Domain Architecture
Description	Transitional endoplasmic reticulum ATPase (TER ATPase) (15S Mg(2+)- ATPase p97 subunit) (Valosin-containing protein) (VCP).

TERA_MOUSE
θ value	1.89707e-74 (rank : 6)	NC score	0.961074 (rank : 4)
Query Neighborhood Hits	94	Target Neighborhood Hits	76	Shared Neighborhood Hits	67
SwissProt Accessions	Q01853	Gene names	Vcp
Domain Architecture
Description	Transitional endoplasmic reticulum ATPase (TER ATPase) (15S Mg(2+)- ATPase p97 subunit) (Valosin-containing protein) (VCP).

PEX1_HUMAN
θ value	3.03575e-64 (rank : 7)	NC score	0.956028 (rank : 7)
Query Neighborhood Hits	94	Target Neighborhood Hits	98	Shared Neighborhood Hits	63
SwissProt Accessions	O43933, Q96S71, Q96S72, Q96S73, Q99994	Gene names	PEX1
Domain Architecture
Description	Peroxisome biogenesis factor 1 (Peroxin-1) (Peroxisome biogenesis disorder protein 1).

PRS8_HUMAN
θ value	3.15612e-45 (rank : 8)	NC score	0.938122 (rank : 8)
Query Neighborhood Hits	94	Target Neighborhood Hits	117	Shared Neighborhood Hits	61
SwissProt Accessions	P62195, O35051, O43208, P47210, P52915, P52916	Gene names	PSMC5, SUG1
Domain Architecture
Description	26S protease regulatory subunit 8 (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (p45/SUG) (Thyroid hormone receptor- interacting protein 1) (TRIP1).

PRS8_MOUSE
θ value	3.15612e-45 (rank : 9)	NC score	0.938122 (rank : 9)
Query Neighborhood Hits	94	Target Neighborhood Hits	117	Shared Neighborhood Hits	61
SwissProt Accessions	P62196, O35051, P47210, P52915, P52916, Q3UL51, Q9CWN5	Gene names	Psmc5, Sug1
Domain Architecture
Description	26S protease regulatory subunit 8 (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (p45/SUG) (mSUG1).

AFG32_HUMAN
θ value	2.26182e-43 (rank : 10)	NC score	0.921192 (rank : 22)
Query Neighborhood Hits	94	Target Neighborhood Hits	72	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y4W6	Gene names	AFG3L2
Domain Architecture
Description	AFG3-like protein 2 (EC 3.4.24.-) (Paraplegin-like protein).

AFG32_MOUSE
θ value	2.26182e-43 (rank : 11)	NC score	0.920744 (rank : 23)
Query Neighborhood Hits	94	Target Neighborhood Hits	73	Shared Neighborhood Hits	60
SwissProt Accessions	Q8JZQ2	Gene names	Afg3l2
Domain Architecture	No domain graphic available
Description	AFG3-like protein 2 (EC 3.4.24.-).

AFG31_MOUSE
θ value	3.85808e-43 (rank : 12)	NC score	0.925023 (rank : 19)
Query Neighborhood Hits	94	Target Neighborhood Hits	74	Shared Neighborhood Hits	60
SwissProt Accessions	Q920A7	Gene names	Afg3l1
Domain Architecture
Description	AFG3-like protein 1 (EC 3.4.24.-).

PRS4_HUMAN
θ value	1.2411e-41 (rank : 13)	NC score	0.934074 (rank : 12)
Query Neighborhood Hits	94	Target Neighborhood Hits	84	Shared Neighborhood Hits	63
SwissProt Accessions	P62191, P49014, Q03527, Q6IAW0, Q96AZ3	Gene names	PSMC1
Domain Architecture
Description	26S protease regulatory subunit 4 (P26s4) (Proteasome 26S subunit ATPase 1).

PRS4_MOUSE
θ value	1.2411e-41 (rank : 14)	NC score	0.934074 (rank : 13)
Query Neighborhood Hits	94	Target Neighborhood Hits	84	Shared Neighborhood Hits	63
SwissProt Accessions	P62192, P49014, Q03527, Q96AZ3	Gene names	Psmc1
Domain Architecture
Description	26S protease regulatory subunit 4 (P26s4) (Proteasome 26S subunit ATPase 1).

PRS6A_HUMAN
θ value	3.05695e-40 (rank : 15)	NC score	0.932616 (rank : 15)
Query Neighborhood Hits	94	Target Neighborhood Hits	87	Shared Neighborhood Hits	60
SwissProt Accessions	P17980, Q96HD3	Gene names	PSMC3, TBP1
Domain Architecture
Description	26S protease regulatory subunit 6A (Proteasome 26S subunit ATPase 3) (TAT-binding protein 1) (TBP-1) (Proteasome subunit P50).

PRS6A_MOUSE
θ value	5.21438e-40 (rank : 16)	NC score	0.932871 (rank : 14)
Query Neighborhood Hits	94	Target Neighborhood Hits	85	Shared Neighborhood Hits	60
SwissProt Accessions	O88685	Gene names	Psmc3, Tbp1
Domain Architecture
Description	26S protease regulatory subunit 6A (Proteasome 26S subunit ATPase 3) (TAT-binding protein 1) (TBP-1).

PRS10_HUMAN
θ value	9.83387e-39 (rank : 17)	NC score	0.935569 (rank : 10)
Query Neighborhood Hits	94	Target Neighborhood Hits	95	Shared Neighborhood Hits	67
SwissProt Accessions	P62333, P49719, Q6IBU3, Q92524	Gene names	PSMC6, SUG2
Domain Architecture
Description	26S protease regulatory subunit S10B (Proteasome subunit p42) (Proteasome 26S subunit ATPase 6).

PRS10_MOUSE
θ value	9.83387e-39 (rank : 18)	NC score	0.935569 (rank : 11)
Query Neighborhood Hits	94	Target Neighborhood Hits	95	Shared Neighborhood Hits	67
SwissProt Accessions	P62334, P49719, Q3TKK1, Q810A6, Q92524, Q9CXH9	Gene names	Psmc6, Sug2
Domain Architecture
Description	26S protease regulatory subunit S10B (Proteasome subunit p42) (Proteasome 26S subunit ATPase 6).

KATL1_MOUSE
θ value	2.19075e-38 (rank : 19)	NC score	0.919486 (rank : 24)
Query Neighborhood Hits	94	Target Neighborhood Hits	77	Shared Neighborhood Hits	64
SwissProt Accessions	Q8K0T4	Gene names	Katnal1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A-like 1 (EC 3.6.4.3) (Katanin p60 subunit A-like 1) (p60 katanin-like 1).

SPG7_HUMAN
θ value	6.37413e-38 (rank : 20)	NC score	0.922967 (rank : 21)
Query Neighborhood Hits	94	Target Neighborhood Hits	71	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UQ90, O75756, Q96IB0	Gene names	SPG7, CAR, CMAR, PGN
Domain Architecture
Description	Paraplegin (EC 3.4.24.-) (Spastic paraplegia protein 7).

KATL1_HUMAN
θ value	3.16345e-37 (rank : 21)	NC score	0.918518 (rank : 25)
Query Neighborhood Hits	94	Target Neighborhood Hits	80	Shared Neighborhood Hits	64
SwissProt Accessions	Q9BW62	Gene names	KATNAL1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A-like 1 (EC 3.6.4.3) (Katanin p60 subunit A-like 1) (p60 katanin-like 1).

KTNA1_MOUSE
θ value	5.39604e-37 (rank : 22)	NC score	0.913375 (rank : 30)
Query Neighborhood Hits	94	Target Neighborhood Hits	123	Shared Neighborhood Hits	64
SwissProt Accessions	Q9WV86	Gene names	Katna1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A1 (EC 3.6.4.3) (Katanin p60 subunit A1) (p60 katanin) (Lipotransin).

KTNA1_HUMAN
θ value	7.04741e-37 (rank : 23)	NC score	0.914815 (rank : 28)
Query Neighborhood Hits	94	Target Neighborhood Hits	117	Shared Neighborhood Hits	63
SwissProt Accessions	O75449, Q5TFA8, Q5TFA9, Q86VN2, Q9NU52	Gene names	KATNA1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A1 (EC 3.6.4.3) (Katanin p60 subunit A1) (p60 katanin).

PRS7_HUMAN
θ value	1.01765e-35 (rank : 24)	NC score	0.930853 (rank : 16)
Query Neighborhood Hits	94	Target Neighborhood Hits	66	Shared Neighborhood Hits	58
SwissProt Accessions	P35998	Gene names	PSMC2, MSS1
Domain Architecture
Description	26S protease regulatory subunit 7 (Proteasome 26S subunit ATPase 2) (Protein MSS1).

PRS7_MOUSE
θ value	1.01765e-35 (rank : 25)	NC score	0.930844 (rank : 17)
Query Neighborhood Hits	94	Target Neighborhood Hits	67	Shared Neighborhood Hits	58
SwissProt Accessions	P46471, O08531, Q3TGX5, Q9DBA1	Gene names	Psmc2, Mss1
Domain Architecture
Description	26S protease regulatory subunit 7 (Proteasome 26S subunit ATPase 2) (Protein MSS1).

YMEL1_MOUSE
θ value	1.9192e-34 (rank : 26)	NC score	0.914569 (rank : 29)
Query Neighborhood Hits	94	Target Neighborhood Hits	76	Shared Neighborhood Hits	61
SwissProt Accessions	O88967, Q7TNN5	Gene names	Yme1l1
Domain Architecture
Description	ATP-dependent metalloprotease YME1L1 (EC 3.4.24.-) (YME1-like protein 1) (ATP-dependent metalloprotease FtsH1).

ATAD2_MOUSE
θ value	2.12192e-33 (rank : 27)	NC score	0.873893 (rank : 40)
Query Neighborhood Hits	94	Target Neighborhood Hits	167	Shared Neighborhood Hits	58
SwissProt Accessions	Q8CDM1	Gene names	Atad2
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 2.

ATAD2_HUMAN
θ value	1.79631e-32 (rank : 28)	NC score	0.855770 (rank : 42)
Query Neighborhood Hits	94	Target Neighborhood Hits	322	Shared Neighborhood Hits	59
SwissProt Accessions	Q6PL18, Q658P2, Q68CQ0, Q6PJV6, Q8N890, Q9UHS5	Gene names	ATAD2
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 2.

PRS6B_HUMAN
θ value	1.16434e-31 (rank : 29)	NC score	0.925036 (rank : 18)
Query Neighborhood Hits	94	Target Neighborhood Hits	85	Shared Neighborhood Hits	56
SwissProt Accessions	P43686, Q96FV5, Q9UBM3, Q9UEX3	Gene names	PSMC4, TBP7
Domain Architecture
Description	26S protease regulatory subunit 6B (Proteasome 26S subunit ATPase 4) (MIP224) (MB67-interacting protein) (TAT-binding protein 7) (TBP-7).

NSF_HUMAN
θ value	1.98606e-31 (rank : 30)	NC score	0.909686 (rank : 32)
Query Neighborhood Hits	94	Target Neighborhood Hits	74	Shared Neighborhood Hits	64
SwissProt Accessions	P46459, Q9UKZ2	Gene names	NSF
Domain Architecture
Description	Vesicle-fusing ATPase (EC 3.6.4.6) (Vesicular-fusion protein NSF) (N- ethylmaleimide sensitive fusion protein) (NEM-sensitive fusion protein).

NSF_MOUSE
θ value	1.98606e-31 (rank : 31)	NC score	0.909766 (rank : 31)
Query Neighborhood Hits	94	Target Neighborhood Hits	73	Shared Neighborhood Hits	63
SwissProt Accessions	P46460	Gene names	Nsf, Skd2
Domain Architecture
Description	Vesicle-fusing ATPase (EC 3.6.4.6) (Vesicular-fusion protein NSF) (N- ethylmaleimide sensitive fusion protein) (NEM-sensitive fusion protein) (SKD2 protein).

VPS4B_MOUSE
θ value	2.59387e-31 (rank : 32)	NC score	0.899229 (rank : 37)
Query Neighborhood Hits	94	Target Neighborhood Hits	86	Shared Neighborhood Hits	60
SwissProt Accessions	P46467, Q91W22, Q9R1C9	Gene names	Vps4b, Skd1
Domain Architecture
Description	Vacuolar protein sorting-associating protein 4B (Protein SKD1).

SPAST_MOUSE
θ value	3.3877e-31 (rank : 33)	NC score	0.904334 (rank : 35)
Query Neighborhood Hits	94	Target Neighborhood Hits	138	Shared Neighborhood Hits	60
SwissProt Accessions	Q9QYY8, Q6ZPY6, Q80VE0, Q9CVK0	Gene names	Spast, Kiaa1083, Spg4
Domain Architecture	No domain graphic available
Description	Spastin.

VPS4B_HUMAN
θ value	4.42448e-31 (rank : 34)	NC score	0.899840 (rank : 36)
Query Neighborhood Hits	94	Target Neighborhood Hits	87	Shared Neighborhood Hits	60
SwissProt Accessions	O75351, Q9GZS7	Gene names	VPS4B, SKD1, VPS42
Domain Architecture
Description	Vacuolar protein sorting-associating protein 4B (Protein SKD1).

PRS6B_MOUSE
θ value	5.77852e-31 (rank : 35)	NC score	0.924357 (rank : 20)
Query Neighborhood Hits	94	Target Neighborhood Hits	89	Shared Neighborhood Hits	56
SwissProt Accessions	P54775	Gene names	Psmc4, Tbp7
Domain Architecture
Description	26S protease regulatory subunit 6B (Proteasome 26S subunit ATPase 4) (MIP224) (MB67-interacting protein) (TAT-binding protein 7) (TBP-7) (CIP21).

SPAST_HUMAN
θ value	5.77852e-31 (rank : 36)	NC score	0.905286 (rank : 34)
Query Neighborhood Hits	94	Target Neighborhood Hits	100	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UBP0, Q9UPR9	Gene names	SPAST, KIAA1083, SPG4
Domain Architecture
Description	Spastin.

VPS4A_HUMAN
θ value	3.74554e-30 (rank : 37)	NC score	0.897767 (rank : 38)
Query Neighborhood Hits	94	Target Neighborhood Hits	95	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UN37, Q8TF07, Q9UI03, Q9Y582	Gene names	VPS4A, VPS4
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associating protein 4A (SKD2 protein) (hVPS4) (VPS4-1).

VPS4A_MOUSE
θ value	3.74554e-30 (rank : 38)	NC score	0.897766 (rank : 39)
Query Neighborhood Hits	94	Target Neighborhood Hits	94	Shared Neighborhood Hits	62
SwissProt Accessions	Q8VEJ9, Q3TXT2	Gene names	Vps4a
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associating protein 4A.

YMEL1_HUMAN
θ value	4.57862e-28 (rank : 39)	NC score	0.908071 (rank : 33)
Query Neighborhood Hits	94	Target Neighborhood Hits	73	Shared Neighborhood Hits	61
SwissProt Accessions	Q96TA2, Q9H1Q0, Q9UMR9	Gene names	YME1L1, FTSH1, YME1L
Domain Architecture
Description	ATP-dependent metalloprotease YME1L1 (EC 3.4.24.-) (YME1-like protein 1) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin- associated metalloprotease) (PAMP).

ATAD1_HUMAN
θ value	5.59698e-26 (rank : 40)	NC score	0.916818 (rank : 26)
Query Neighborhood Hits	94	Target Neighborhood Hits	75	Shared Neighborhood Hits	65
SwissProt Accessions	Q8NBU5, Q6P4B9, Q8N3G1, Q8WYR9, Q969Y3	Gene names	ATAD1
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 1.

ATAD1_MOUSE
θ value	5.59698e-26 (rank : 41)	NC score	0.916818 (rank : 27)
Query Neighborhood Hits	94	Target Neighborhood Hits	75	Shared Neighborhood Hits	65
SwissProt Accessions	Q9D5T0, Q3U8V2, Q9D7A4	Gene names	Atad1
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 1.

FIGN_MOUSE
θ value	3.17815e-21 (rank : 42)	NC score	0.856532 (rank : 41)
Query Neighborhood Hits	94	Target Neighborhood Hits	165	Shared Neighborhood Hits	55
SwissProt Accessions	Q9ERZ6, Q3TPB0, Q3UP57, Q6PCM0	Gene names	Fign
Domain Architecture	No domain graphic available
Description	Fidgetin.

FIGN_HUMAN
θ value	5.42112e-21 (rank : 43)	NC score	0.851313 (rank : 43)
Query Neighborhood Hits	94	Target Neighborhood Hits	176	Shared Neighborhood Hits	55
SwissProt Accessions	Q5HY92, Q9H6M5, Q9NVZ9	Gene names	FIGN
Domain Architecture	No domain graphic available
Description	Fidgetin.

TRP13_HUMAN
θ value	3.41135e-07 (rank : 44)	NC score	0.704661 (rank : 45)
Query Neighborhood Hits	94	Target Neighborhood Hits	81	Shared Neighborhood Hits	63
SwissProt Accessions	Q15645, O15324	Gene names	TRIP13
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 13 (Thyroid hormone receptor interactor 13) (Trip-13) (Human papillomavirus type 16 E1 protein- binding protein) (HPV16 E1 protein-binding protein) (16E1-BP).

TRP13_MOUSE
θ value	3.41135e-07 (rank : 45)	NC score	0.707141 (rank : 44)
Query Neighborhood Hits	94	Target Neighborhood Hits	81	Shared Neighborhood Hits	62
SwissProt Accessions	Q3UA06, Q3UQG6, Q9CWW8	Gene names	Trip13
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 13 (Thyroid hormone receptor interactor 13) (Trip-13).

BCS1_HUMAN
θ value	5.81887e-07 (rank : 46)	NC score	0.675928 (rank : 46)
Query Neighborhood Hits	94	Target Neighborhood Hits	61	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y276, Q7Z2V7	Gene names	BCS1L, BCS1
Domain Architecture
Description	Mitochondrial chaperone BCS1 (BCS1-like protein) (H-BCS1).

BCS1_MOUSE
θ value	9.92553e-07 (rank : 47)	NC score	0.665097 (rank : 47)
Query Neighborhood Hits	94	Target Neighborhood Hits	64	Shared Neighborhood Hits	54
SwissProt Accessions	Q9CZP5	Gene names	Bcs1l
Domain Architecture
Description	Mitochondrial chaperone BCS1 (BCS1-like protein).

ATAD3_MOUSE
θ value	9.29e-05 (rank : 48)	NC score	0.573162 (rank : 50)
Query Neighborhood Hits	94	Target Neighborhood Hits	326	Shared Neighborhood Hits	62
SwissProt Accessions	Q925I1, Q3UE74, Q69ZM7, Q8C6C6	Gene names	Atad3, Atad3a, Kiaa1273
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3 (AAA-ATPase TOB3).

LONM_HUMAN
θ value	0.000602161 (rank : 49)	NC score	0.446344 (rank : 51)
Query Neighborhood Hits	94	Target Neighborhood Hits	130	Shared Neighborhood Hits	59
SwissProt Accessions	P36776, P36777, Q9UQ95	Gene names	PRSS15
Domain Architecture
Description	Lon protease homolog, mitochondrial precursor (EC 3.4.21.-) (Lon protease-like protein) (LONP) (LONHs).

ATD3A_HUMAN
θ value	0.00134147 (rank : 50)	NC score	0.586266 (rank : 48)
Query Neighborhood Hits	94	Target Neighborhood Hits	248	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NVI7, Q8N275, Q96A50	Gene names	ATAD3A
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3A.

ATD3B_HUMAN
θ value	0.00228821 (rank : 51)	NC score	0.575676 (rank : 49)
Query Neighborhood Hits	94	Target Neighborhood Hits	340	Shared Neighborhood Hits	61
SwissProt Accessions	Q5T9A4, Q6ZRB5, Q9BUK4, Q9ULE7	Gene names	ATAD3B, KIAA1273
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3B.

CLPX_HUMAN
θ value	0.00298849 (rank : 52)	NC score	0.431575 (rank : 52)
Query Neighborhood Hits	94	Target Neighborhood Hits	72	Shared Neighborhood Hits	53
SwissProt Accessions	O76031, Q9H4D9	Gene names	CLPX
Domain Architecture
Description	ATP-dependent Clp protease ATP-binding subunit ClpX-like, mitochondrial precursor.

CLPX_MOUSE
θ value	0.00298849 (rank : 53)	NC score	0.429376 (rank : 53)
Query Neighborhood Hits	94	Target Neighborhood Hits	73	Shared Neighborhood Hits	53
SwissProt Accessions	Q9JHS4, Q9WVD1	Gene names	Clpx
Domain Architecture
Description	ATP-dependent Clp protease ATP-binding subunit ClpX-like, mitochondrial precursor.

SMBP2_MOUSE
θ value	0.0252991 (rank : 54)	NC score	0.048294 (rank : 73)
Query Neighborhood Hits	94	Target Neighborhood Hits	104	Shared Neighborhood Hits	12
SwissProt Accessions	P40694	Gene names	Ighmbp2, Smbp-2, Smbp2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Cardiac transcription factor 1) (CATF1).

RFC1_MOUSE
θ value	0.125558 (rank : 55)	NC score	0.146940 (rank : 58)
Query Neighborhood Hits	94	Target Neighborhood Hits	290	Shared Neighborhood Hits	50
SwissProt Accessions	P35601	Gene names	Rfc1, Ibf-1, Recc1
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (A1-P145) (Differentiation- specific element-binding protein) (ISRE-binding protein).

RUVB1_HUMAN
θ value	0.125558 (rank : 56)	NC score	0.312767 (rank : 54)
Query Neighborhood Hits	94	Target Neighborhood Hits	78	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y265, Q9BSX9	Gene names	RUVBL1, NMP238, TIP49, TIP49A
Domain Architecture
Description	RuvB-like 1 (EC 3.6.1.-) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (TIP49a) (Pontin 52) (Nuclear matrix protein 238) (NMP 238) (54 kDa erythrocyte cytosolic protein) (ECP-54) (TIP60-associated protein 54-alpha) (TAP54-alpha).

RUVB1_MOUSE
θ value	0.125558 (rank : 57)	NC score	0.312727 (rank : 55)
Query Neighborhood Hits	94	Target Neighborhood Hits	78	Shared Neighborhood Hits	65
SwissProt Accessions	P60122, O35753	Gene names	Ruvbl1, Tip49, Tip49a
Domain Architecture
Description	RuvB-like 1 (EC 3.6.1.-) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (TIP49a) (Pontin 52) (DNA helicase p50).

MRE11_MOUSE
θ value	0.21417 (rank : 58)	NC score	0.023596 (rank : 78)
Query Neighborhood Hits	94	Target Neighborhood Hits	137	Shared Neighborhood Hits	2
SwissProt Accessions	Q61216, Q62430	Gene names	Mre11a, Mre11
Domain Architecture
Description	Double-strand break repair protein MRE11A (MRE11 homolog 1) (MRE11 meiotic recombination 11 homolog A) (MmMRE11A).

RFC1_HUMAN
θ value	0.279714 (rank : 59)	NC score	0.132663 (rank : 59)
Query Neighborhood Hits	94	Target Neighborhood Hits	352	Shared Neighborhood Hits	47
SwissProt Accessions	P35251, Q5XKF5, Q6PKU0, Q86V41, Q86V46	Gene names	RFC1, RFC140
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (DNA-binding protein PO-GA).

RFC4_HUMAN
θ value	0.279714 (rank : 60)	NC score	0.127590 (rank : 60)
Query Neighborhood Hits	94	Target Neighborhood Hits	64	Shared Neighborhood Hits	42
SwissProt Accessions	P35249, Q6FHX7	Gene names	RFC4
Domain Architecture
Description	Replication factor C subunit 4 (Replication factor C 37 kDa subunit) (RF-C 37 kDa subunit) (RFC37) (Activator 1 37 kDa subunit) (A1 37 kDa subunit).

SMBP2_HUMAN
θ value	0.365318 (rank : 61)	NC score	0.040569 (rank : 76)
Query Neighborhood Hits	94	Target Neighborhood Hits	107	Shared Neighborhood Hits	11
SwissProt Accessions	P38935, Q00443, Q14177	Gene names	IGHMBP2, SMBP2, SMUBP2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Glial factor 1) (GF-1).

THNSL_HUMAN
θ value	0.62314 (rank : 62)	NC score	0.122821 (rank : 62)
Query Neighborhood Hits	94	Target Neighborhood Hits	47	Shared Neighborhood Hits	37
SwissProt Accessions	Q8IYQ7, Q5VV21	Gene names	THNSL1
Domain Architecture	No domain graphic available
Description	Threonine synthase-like 1.

TOR1B_HUMAN
θ value	0.62314 (rank : 63)	NC score	0.024666 (rank : 77)
Query Neighborhood Hits	94	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	O14657	Gene names	TOR1B, DQ1
Domain Architecture
Description	Torsin B precursor (Torsin family 1 member B).

THNSL_MOUSE
θ value	0.813845 (rank : 64)	NC score	0.123854 (rank : 61)
Query Neighborhood Hits	94	Target Neighborhood Hits	47	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BH55	Gene names	Thnsl1
Domain Architecture	No domain graphic available
Description	Threonine synthase-like 1.

RFC4_MOUSE
θ value	1.06291 (rank : 65)	NC score	0.113732 (rank : 63)
Query Neighborhood Hits	94	Target Neighborhood Hits	65	Shared Neighborhood Hits	42
SwissProt Accessions	Q99J62	Gene names	Rfc4
Domain Architecture	No domain graphic available
Description	Replication factor C subunit 4.

TOR1B_MOUSE
θ value	1.06291 (rank : 66)	NC score	0.022875 (rank : 79)
Query Neighborhood Hits	94	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ER41	Gene names	Tor1b
Domain Architecture
Description	Torsin B precursor (Torsin family 1 member B).

NALP7_HUMAN
θ value	1.38821 (rank : 67)	NC score	0.020059 (rank : 81)
Query Neighborhood Hits	94	Target Neighborhood Hits	65	Shared Neighborhood Hits	14
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

ZNFX1_HUMAN
θ value	1.38821 (rank : 68)	NC score	0.020474 (rank : 80)
Query Neighborhood Hits	94	Target Neighborhood Hits	308	Shared Neighborhood Hits	10
SwissProt Accessions	Q9P2E3, Q9BQM7, Q9BQM8, Q9H8C1, Q9H9S2, Q9NUM1, Q9NWW1	Gene names	ZNFX1, KIAA1404
Domain Architecture	No domain graphic available
Description	NFX1-type zinc finger-containing protein 1.

AQR_HUMAN
θ value	1.81305 (rank : 69)	NC score	0.046157 (rank : 75)
Query Neighborhood Hits	94	Target Neighborhood Hits	88	Shared Neighborhood Hits	16
SwissProt Accessions	O60306, Q2YDX9, Q6IRU8, Q6PIC8	Gene names	AQR, KIAA0560
Domain Architecture	No domain graphic available
Description	Intron-binding protein aquarius (Intron-binding protein of 160 kDa) (IBP160).

AQR_MOUSE
θ value	1.81305 (rank : 70)	NC score	0.046830 (rank : 74)
Query Neighborhood Hits	94	Target Neighborhood Hits	62	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CFQ3, P97871, Q3U9N1, Q3ULE8, Q80TX8	Gene names	Aqr, Kiaa0560
Domain Architecture	No domain graphic available
Description	Intron-binding protein aquarius.

MUC5B_HUMAN
θ value	1.81305 (rank : 71)	NC score	0.002629 (rank : 94)
Query Neighborhood Hits	94	Target Neighborhood Hits	1020	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

RAD17_MOUSE
θ value	1.81305 (rank : 72)	NC score	0.067164 (rank : 70)
Query Neighborhood Hits	94	Target Neighborhood Hits	63	Shared Neighborhood Hits	29
SwissProt Accessions	Q6NXW6, O88934, O89024	Gene names	Rad17
Domain Architecture	No domain graphic available
Description	Cell cycle checkpoint protein RAD17.

CNKR1_HUMAN
θ value	2.36792 (rank : 73)	NC score	0.011332 (rank : 82)
Query Neighborhood Hits	94	Target Neighborhood Hits	154	Shared Neighborhood Hits	2
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

PARC_HUMAN
θ value	2.36792 (rank : 74)	NC score	0.007363 (rank : 86)
Query Neighborhood Hits	94	Target Neighborhood Hits	148	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IWT3, O75188, Q68CP2, Q68D92, Q8N3W9, Q9BU56	Gene names	PARC, H7AP1, KIAA0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein (UbcH7-associated protein 1).

COT1_HUMAN
θ value	3.0926 (rank : 75)	NC score	0.002270 (rank : 95)
Query Neighborhood Hits	94	Target Neighborhood Hits	159	Shared Neighborhood Hits	3
SwissProt Accessions	P10589	Gene names	NR2F1, EAR3, ERBAL3, TFCOUP1
Domain Architecture
Description	COUP transcription factor 1 (COUP-TF1) (COUP-TF I) (V-ERBA-related protein EAR-3).

COT1_MOUSE
θ value	4.03905 (rank : 76)	NC score	0.002046 (rank : 96)
Query Neighborhood Hits	94	Target Neighborhood Hits	160	Shared Neighborhood Hits	3
SwissProt Accessions	Q60632, Q61438	Gene names	Nr2f1, Erbal3, Tfcoup1
Domain Architecture
Description	COUP transcription factor 1 (COUP-TF1) (COUP-TF I).

CRSP7_HUMAN
θ value	4.03905 (rank : 77)	NC score	0.009697 (rank : 85)
Query Neighborhood Hits	94	Target Neighborhood Hits	247	Shared Neighborhood Hits	3
SwissProt Accessions	O95402	Gene names	CRSP7, ARC70
Domain Architecture
Description	CRSP complex subunit 7 (Cofactor required for Sp1 transcriptional activation subunit 7) (Transcriptional coactivator CRSP70) (Activator- recruited cofactor 70 kDa component) (ARC70).

GALK2_MOUSE
θ value	4.03905 (rank : 78)	NC score	0.010063 (rank : 84)
Query Neighborhood Hits	94	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q68FH4	Gene names	Galk2
Domain Architecture	No domain graphic available
Description	N-acetylgalactosamine kinase (EC 2.7.1.157) (GalNAc kinase) (Galactokinase 2).

KAD6_HUMAN
θ value	4.03905 (rank : 79)	NC score	0.113321 (rank : 65)
Query Neighborhood Hits	94	Target Neighborhood Hits	46	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y3D8	Gene names	AK6
Domain Architecture
Description	Adenylate kinase isoenzyme 6 (EC 2.7.4.3) (ATP-AMP transphosphorylase 6).

NALP5_MOUSE
θ value	4.03905 (rank : 80)	NC score	0.010892 (rank : 83)
Query Neighborhood Hits	94	Target Neighborhood Hits	560	Shared Neighborhood Hits	12
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

PO3F3_HUMAN
θ value	4.03905 (rank : 81)	NC score	0.003433 (rank : 91)
Query Neighborhood Hits	94	Target Neighborhood Hits	311	Shared Neighborhood Hits	3
SwissProt Accessions	P20264, P78379	Gene names	POU3F3, BRN1, OTF8
Domain Architecture
Description	POU domain, class 3, transcription factor 3 (Brain-specific homeobox/POU domain protein 1) (Brain-1) (Brn-1 protein).

PO3F3_MOUSE
θ value	4.03905 (rank : 82)	NC score	0.003429 (rank : 92)
Query Neighborhood Hits	94	Target Neighborhood Hits	308	Shared Neighborhood Hits	3
SwissProt Accessions	P31361	Gene names	Pou3f3, Brn-1, Brn1, Otf8
Domain Architecture
Description	POU domain, class 3, transcription factor 3 (Brain-specific homeobox/POU domain protein 1) (Brain-1) (Brn-1 protein).

WRIP1_HUMAN
θ value	4.03905 (rank : 83)	NC score	0.220826 (rank : 56)
Query Neighborhood Hits	94	Target Neighborhood Hits	100	Shared Neighborhood Hits	56
SwissProt Accessions	Q96S55, Q53EP6, Q59ET8, Q5W0E2, Q5W0E4, Q8WV26, Q9H681, Q9NRJ6	Gene names	WRNIP1, WHIP
Domain Architecture	No domain graphic available
Description	ATPase WRNIP1 (Werner helicase-interacting protein 1).

CO4A_HUMAN
θ value	5.27518 (rank : 84)	NC score	0.007108 (rank : 87)
Query Neighborhood Hits	94	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	P0C0L4, P01028, P78445, Q13160, Q13906, Q14033, Q14835, Q5JQM8, Q9NPK5, Q9UIP5	Gene names	C4A
Domain Architecture	No domain graphic available
Description	Complement C4-A precursor (Acidic complement C4) [Contains: Complement C4 beta chain; Complement C4-A alpha chain; C4a anaphylatoxin; C4b-A; C4d-A; Complement C4 gamma chain].

CO4B_HUMAN
θ value	5.27518 (rank : 85)	NC score	0.007104 (rank : 88)
Query Neighborhood Hits	94	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	P0C0L5, P01028, P78445, Q13160, Q13906, Q14033, Q14835, Q9NPK5, Q9UIP5	Gene names	C4B
Domain Architecture	No domain graphic available
Description	Complement C4-B precursor (Basic complement C4) [Contains: Complement C4 beta chain; Complement C4-B alpha chain; C4a anaphylatoxin; C4b-B; C4d-B; Complement C4 gamma chain].

KAD6_MOUSE
θ value	5.27518 (rank : 86)	NC score	0.090208 (rank : 67)
Query Neighborhood Hits	94	Target Neighborhood Hits	34	Shared Neighborhood Hits	21
SwissProt Accessions	Q8VCP8	Gene names	Ak6
Domain Architecture	No domain graphic available
Description	Adenylate kinase isoenzyme 6 (EC 2.7.4.3) (ATP-AMP transphosphorylase 6).

RFC5_HUMAN
θ value	6.88961 (rank : 87)	NC score	0.076538 (rank : 69)
Query Neighborhood Hits	94	Target Neighborhood Hits	60	Shared Neighborhood Hits	36
SwissProt Accessions	P40937	Gene names	RFC5
Domain Architecture
Description	Replication factor C subunit 5 (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36) (Activator 1 36 kDa subunit) (A1 36 kDa subunit).

RFC5_MOUSE
θ value	6.88961 (rank : 88)	NC score	0.077258 (rank : 68)
Query Neighborhood Hits	94	Target Neighborhood Hits	58	Shared Neighborhood Hits	38
SwissProt Accessions	Q9D0F6	Gene names	Rfc5
Domain Architecture
Description	Replication factor C subunit 5 (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36) (Activator 1 36 kDa subunit) (A1 36 kDa subunit).

BIRC1_HUMAN
θ value	8.99809 (rank : 89)	NC score	0.004169 (rank : 90)
Query Neighborhood Hits	94	Target Neighborhood Hits	61	Shared Neighborhood Hits	5
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

IRF3_HUMAN
θ value	8.99809 (rank : 90)	NC score	0.002991 (rank : 93)
Query Neighborhood Hits	94	Target Neighborhood Hits	129	Shared Neighborhood Hits	3
SwissProt Accessions	Q14653	Gene names	IRF3
Domain Architecture
Description	Interferon regulatory factor 3 (IRF-3).

PTN14_HUMAN
θ value	8.99809 (rank : 91)	NC score	-0.000412 (rank : 97)
Query Neighborhood Hits	94	Target Neighborhood Hits	163	Shared Neighborhood Hits	2
SwissProt Accessions	Q15678	Gene names	PTPN14, PEZ
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez).

RFC2_HUMAN
θ value	8.99809 (rank : 92)	NC score	0.055092 (rank : 71)
Query Neighborhood Hits	94	Target Neighborhood Hits	46	Shared Neighborhood Hits	25
SwissProt Accessions	P35250, P32846, Q9BU93	Gene names	RFC2
Domain Architecture
Description	Replication factor C subunit 2 (Replication factor C 40 kDa subunit) (RF-C 40 kDa subunit) (RFC40) (Activator 1 40 kDa subunit) (A1 40 kDa subunit).

RFC2_MOUSE
θ value	8.99809 (rank : 93)	NC score	0.052667 (rank : 72)
Query Neighborhood Hits	94	Target Neighborhood Hits	46	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WUK4	Gene names	Rfc2
Domain Architecture
Description	Replication factor C subunit 2 (Replication factor C 40 kDa subunit) (RF-C 40 kDa subunit) (RFC40) (Activator 1 40 kDa subunit) (A1 40 kDa subunit).

TSC2_HUMAN
θ value	8.99809 (rank : 94)	NC score	0.004558 (rank : 89)
Query Neighborhood Hits	94	Target Neighborhood Hits	59	Shared Neighborhood Hits	2
SwissProt Accessions	P49815, O75275, Q8TAZ1	Gene names	TSC2
Domain Architecture
Description	Tuberin (Tuberous sclerosis 2 protein).

RUVB2_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.113528 (rank : 64)
Query Neighborhood Hits	94	Target Neighborhood Hits	43	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y230, Q6PK27, Q9Y361	Gene names	RUVBL2, TIP48, TIP49B
Domain Architecture
Description	RuvB-like 2 (EC 3.6.1.-) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (TIP49b) (Repressing pontin 52) (Reptin 52) (51 kDa erythrocyte cytosolic protein) (ECP-51) (TIP60-associated protein 54-beta) (TAP54-beta).

RUVB2_MOUSE
θ value	θ > 10 (rank : 96)	NC score	0.110884 (rank : 66)
Query Neighborhood Hits	94	Target Neighborhood Hits	42	Shared Neighborhood Hits	37
SwissProt Accessions	Q9WTM5	Gene names	Ruvbl2
Domain Architecture
Description	RuvB-like 2 (EC 3.6.1.-) (p47 protein).

WRIP1_MOUSE
θ value	θ > 10 (rank : 97)	NC score	0.220441 (rank : 57)
Query Neighborhood Hits	94	Target Neighborhood Hits	93	Shared Neighborhood Hits	57
SwissProt Accessions	Q91XU0, Q3TCT7, Q6PDF0, Q8BUW5, Q8BWP6, Q8BY55, Q921W3, Q9EQL3	Gene names	Wrnip1, Whip
Domain Architecture	No domain graphic available
Description	ATPase WRNIP1 (Werner helicase-interacting protein 1).

Hits sorted by NC score

PEX6_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	94	Target Neighborhood Hits	94	Shared Neighborhood Hits	94
SwissProt Accessions	Q99LC9, Q6YNQ9	Gene names	Pex6
Domain Architecture	No domain graphic available
Description	Peroxisome assembly factor 2 (PAF-2) (Peroxisomal-type ATPase 1) (Peroxin-6) (Peroxisomal biogenesis factor 6).

PEX6_HUMAN
NC score	0.998215 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	94	Target Neighborhood Hits	99	Shared Neighborhood Hits	77
SwissProt Accessions	Q13608, Q8WYQ2, Q99476	Gene names	PEX6, PXAAA1
Domain Architecture
Description	Peroxisome assembly factor 2 (PAF-2) (Peroxisomal-type ATPase 1) (Peroxin-6) (Peroxisomal biogenesis factor 6).

TERA_HUMAN
NC score	0.961074 (rank : 3)	θ value	1.89707e-74 (rank : 5)
Query Neighborhood Hits	94	Target Neighborhood Hits	76	Shared Neighborhood Hits	67
SwissProt Accessions	P55072, Q969G7	Gene names	VCP
Domain Architecture
Description	Transitional endoplasmic reticulum ATPase (TER ATPase) (15S Mg(2+)- ATPase p97 subunit) (Valosin-containing protein) (VCP).

TERA_MOUSE
NC score	0.961074 (rank : 4)	θ value	1.89707e-74 (rank : 6)
Query Neighborhood Hits	94	Target Neighborhood Hits	76	Shared Neighborhood Hits	67
SwissProt Accessions	Q01853	Gene names	Vcp
Domain Architecture
Description	Transitional endoplasmic reticulum ATPase (TER ATPase) (15S Mg(2+)- ATPase p97 subunit) (Valosin-containing protein) (VCP).

NVL_MOUSE
NC score	0.960453 (rank : 5)	θ value	1.8332e-77 (rank : 3)
Query Neighborhood Hits	94	Target Neighborhood Hits	110	Shared Neighborhood Hits	70
SwissProt Accessions	Q9DBY8, Q3USC4, Q8BW27, Q8K2B5	Gene names	Nvl
Domain Architecture
Description	Nuclear valosin-containing protein-like (Nuclear VCP-like protein) (NVLp).

NVL_HUMAN
NC score	0.959120 (rank : 6)	θ value	1.18825e-76 (rank : 4)
Query Neighborhood Hits	94	Target Neighborhood Hits	112	Shared Neighborhood Hits	71
SwissProt Accessions	O15381, Q96EM7	Gene names	NVL
Domain Architecture
Description	Nuclear valosin-containing protein-like (Nuclear VCP-like protein) (NVLp).

PEX1_HUMAN
NC score	0.956028 (rank : 7)	θ value	3.03575e-64 (rank : 7)
Query Neighborhood Hits	94	Target Neighborhood Hits	98	Shared Neighborhood Hits	63
SwissProt Accessions	O43933, Q96S71, Q96S72, Q96S73, Q99994	Gene names	PEX1
Domain Architecture
Description	Peroxisome biogenesis factor 1 (Peroxin-1) (Peroxisome biogenesis disorder protein 1).

PRS8_HUMAN
NC score	0.938122 (rank : 8)	θ value	3.15612e-45 (rank : 8)
Query Neighborhood Hits	94	Target Neighborhood Hits	117	Shared Neighborhood Hits	61
SwissProt Accessions	P62195, O35051, O43208, P47210, P52915, P52916	Gene names	PSMC5, SUG1
Domain Architecture
Description	26S protease regulatory subunit 8 (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (p45/SUG) (Thyroid hormone receptor- interacting protein 1) (TRIP1).

PRS8_MOUSE
NC score	0.938122 (rank : 9)	θ value	3.15612e-45 (rank : 9)
Query Neighborhood Hits	94	Target Neighborhood Hits	117	Shared Neighborhood Hits	61
SwissProt Accessions	P62196, O35051, P47210, P52915, P52916, Q3UL51, Q9CWN5	Gene names	Psmc5, Sug1
Domain Architecture
Description	26S protease regulatory subunit 8 (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (p45/SUG) (mSUG1).

PRS10_HUMAN
NC score	0.935569 (rank : 10)	θ value	9.83387e-39 (rank : 17)
Query Neighborhood Hits	94	Target Neighborhood Hits	95	Shared Neighborhood Hits	67
SwissProt Accessions	P62333, P49719, Q6IBU3, Q92524	Gene names	PSMC6, SUG2
Domain Architecture
Description	26S protease regulatory subunit S10B (Proteasome subunit p42) (Proteasome 26S subunit ATPase 6).

PRS10_MOUSE
NC score	0.935569 (rank : 11)	θ value	9.83387e-39 (rank : 18)
Query Neighborhood Hits	94	Target Neighborhood Hits	95	Shared Neighborhood Hits	67
SwissProt Accessions	P62334, P49719, Q3TKK1, Q810A6, Q92524, Q9CXH9	Gene names	Psmc6, Sug2
Domain Architecture
Description	26S protease regulatory subunit S10B (Proteasome subunit p42) (Proteasome 26S subunit ATPase 6).

PRS4_HUMAN
NC score	0.934074 (rank : 12)	θ value	1.2411e-41 (rank : 13)
Query Neighborhood Hits	94	Target Neighborhood Hits	84	Shared Neighborhood Hits	63
SwissProt Accessions	P62191, P49014, Q03527, Q6IAW0, Q96AZ3	Gene names	PSMC1
Domain Architecture
Description	26S protease regulatory subunit 4 (P26s4) (Proteasome 26S subunit ATPase 1).

PRS4_MOUSE
NC score	0.934074 (rank : 13)	θ value	1.2411e-41 (rank : 14)
Query Neighborhood Hits	94	Target Neighborhood Hits	84	Shared Neighborhood Hits	63
SwissProt Accessions	P62192, P49014, Q03527, Q96AZ3	Gene names	Psmc1
Domain Architecture
Description	26S protease regulatory subunit 4 (P26s4) (Proteasome 26S subunit ATPase 1).

PRS6A_MOUSE
NC score	0.932871 (rank : 14)	θ value	5.21438e-40 (rank : 16)
Query Neighborhood Hits	94	Target Neighborhood Hits	85	Shared Neighborhood Hits	60
SwissProt Accessions	O88685	Gene names	Psmc3, Tbp1
Domain Architecture
Description	26S protease regulatory subunit 6A (Proteasome 26S subunit ATPase 3) (TAT-binding protein 1) (TBP-1).

PRS6A_HUMAN
NC score	0.932616 (rank : 15)	θ value	3.05695e-40 (rank : 15)
Query Neighborhood Hits	94	Target Neighborhood Hits	87	Shared Neighborhood Hits	60
SwissProt Accessions	P17980, Q96HD3	Gene names	PSMC3, TBP1
Domain Architecture
Description	26S protease regulatory subunit 6A (Proteasome 26S subunit ATPase 3) (TAT-binding protein 1) (TBP-1) (Proteasome subunit P50).

PRS7_HUMAN
NC score	0.930853 (rank : 16)	θ value	1.01765e-35 (rank : 24)
Query Neighborhood Hits	94	Target Neighborhood Hits	66	Shared Neighborhood Hits	58
SwissProt Accessions	P35998	Gene names	PSMC2, MSS1
Domain Architecture
Description	26S protease regulatory subunit 7 (Proteasome 26S subunit ATPase 2) (Protein MSS1).

PRS7_MOUSE
NC score	0.930844 (rank : 17)	θ value	1.01765e-35 (rank : 25)
Query Neighborhood Hits	94	Target Neighborhood Hits	67	Shared Neighborhood Hits	58
SwissProt Accessions	P46471, O08531, Q3TGX5, Q9DBA1	Gene names	Psmc2, Mss1
Domain Architecture
Description	26S protease regulatory subunit 7 (Proteasome 26S subunit ATPase 2) (Protein MSS1).

PRS6B_HUMAN
NC score	0.925036 (rank : 18)	θ value	1.16434e-31 (rank : 29)
Query Neighborhood Hits	94	Target Neighborhood Hits	85	Shared Neighborhood Hits	56
SwissProt Accessions	P43686, Q96FV5, Q9UBM3, Q9UEX3	Gene names	PSMC4, TBP7
Domain Architecture
Description	26S protease regulatory subunit 6B (Proteasome 26S subunit ATPase 4) (MIP224) (MB67-interacting protein) (TAT-binding protein 7) (TBP-7).

AFG31_MOUSE
NC score	0.925023 (rank : 19)	θ value	3.85808e-43 (rank : 12)
Query Neighborhood Hits	94	Target Neighborhood Hits	74	Shared Neighborhood Hits	60
SwissProt Accessions	Q920A7	Gene names	Afg3l1
Domain Architecture
Description	AFG3-like protein 1 (EC 3.4.24.-).

PRS6B_MOUSE
NC score	0.924357 (rank : 20)	θ value	5.77852e-31 (rank : 35)
Query Neighborhood Hits	94	Target Neighborhood Hits	89	Shared Neighborhood Hits	56
SwissProt Accessions	P54775	Gene names	Psmc4, Tbp7
Domain Architecture
Description	26S protease regulatory subunit 6B (Proteasome 26S subunit ATPase 4) (MIP224) (MB67-interacting protein) (TAT-binding protein 7) (TBP-7) (CIP21).

SPG7_HUMAN
NC score	0.922967 (rank : 21)	θ value	6.37413e-38 (rank : 20)
Query Neighborhood Hits	94	Target Neighborhood Hits	71	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UQ90, O75756, Q96IB0	Gene names	SPG7, CAR, CMAR, PGN
Domain Architecture
Description	Paraplegin (EC 3.4.24.-) (Spastic paraplegia protein 7).

AFG32_HUMAN
NC score	0.921192 (rank : 22)	θ value	2.26182e-43 (rank : 10)
Query Neighborhood Hits	94	Target Neighborhood Hits	72	Shared Neighborhood Hits	60
SwissProt Accessions	Q9Y4W6	Gene names	AFG3L2
Domain Architecture
Description	AFG3-like protein 2 (EC 3.4.24.-) (Paraplegin-like protein).

AFG32_MOUSE
NC score	0.920744 (rank : 23)	θ value	2.26182e-43 (rank : 11)
Query Neighborhood Hits	94	Target Neighborhood Hits	73	Shared Neighborhood Hits	60
SwissProt Accessions	Q8JZQ2	Gene names	Afg3l2
Domain Architecture	No domain graphic available
Description	AFG3-like protein 2 (EC 3.4.24.-).

KATL1_MOUSE
NC score	0.919486 (rank : 24)	θ value	2.19075e-38 (rank : 19)
Query Neighborhood Hits	94	Target Neighborhood Hits	77	Shared Neighborhood Hits	64
SwissProt Accessions	Q8K0T4	Gene names	Katnal1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A-like 1 (EC 3.6.4.3) (Katanin p60 subunit A-like 1) (p60 katanin-like 1).

KATL1_HUMAN
NC score	0.918518 (rank : 25)	θ value	3.16345e-37 (rank : 21)
Query Neighborhood Hits	94	Target Neighborhood Hits	80	Shared Neighborhood Hits	64
SwissProt Accessions	Q9BW62	Gene names	KATNAL1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A-like 1 (EC 3.6.4.3) (Katanin p60 subunit A-like 1) (p60 katanin-like 1).

ATAD1_HUMAN
NC score	0.916818 (rank : 26)	θ value	5.59698e-26 (rank : 40)
Query Neighborhood Hits	94	Target Neighborhood Hits	75	Shared Neighborhood Hits	65
SwissProt Accessions	Q8NBU5, Q6P4B9, Q8N3G1, Q8WYR9, Q969Y3	Gene names	ATAD1
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 1.

ATAD1_MOUSE
NC score	0.916818 (rank : 27)	θ value	5.59698e-26 (rank : 41)
Query Neighborhood Hits	94	Target Neighborhood Hits	75	Shared Neighborhood Hits	65
SwissProt Accessions	Q9D5T0, Q3U8V2, Q9D7A4	Gene names	Atad1
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 1.

KTNA1_HUMAN
NC score	0.914815 (rank : 28)	θ value	7.04741e-37 (rank : 23)
Query Neighborhood Hits	94	Target Neighborhood Hits	117	Shared Neighborhood Hits	63
SwissProt Accessions	O75449, Q5TFA8, Q5TFA9, Q86VN2, Q9NU52	Gene names	KATNA1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A1 (EC 3.6.4.3) (Katanin p60 subunit A1) (p60 katanin).

YMEL1_MOUSE
NC score	0.914569 (rank : 29)	θ value	1.9192e-34 (rank : 26)
Query Neighborhood Hits	94	Target Neighborhood Hits	76	Shared Neighborhood Hits	61
SwissProt Accessions	O88967, Q7TNN5	Gene names	Yme1l1
Domain Architecture
Description	ATP-dependent metalloprotease YME1L1 (EC 3.4.24.-) (YME1-like protein 1) (ATP-dependent metalloprotease FtsH1).

KTNA1_MOUSE
NC score	0.913375 (rank : 30)	θ value	5.39604e-37 (rank : 22)
Query Neighborhood Hits	94	Target Neighborhood Hits	123	Shared Neighborhood Hits	64
SwissProt Accessions	Q9WV86	Gene names	Katna1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A1 (EC 3.6.4.3) (Katanin p60 subunit A1) (p60 katanin) (Lipotransin).

NSF_MOUSE
NC score	0.909766 (rank : 31)	θ value	1.98606e-31 (rank : 31)
Query Neighborhood Hits	94	Target Neighborhood Hits	73	Shared Neighborhood Hits	63
SwissProt Accessions	P46460	Gene names	Nsf, Skd2
Domain Architecture
Description	Vesicle-fusing ATPase (EC 3.6.4.6) (Vesicular-fusion protein NSF) (N- ethylmaleimide sensitive fusion protein) (NEM-sensitive fusion protein) (SKD2 protein).

NSF_HUMAN
NC score	0.909686 (rank : 32)	θ value	1.98606e-31 (rank : 30)
Query Neighborhood Hits	94	Target Neighborhood Hits	74	Shared Neighborhood Hits	64
SwissProt Accessions	P46459, Q9UKZ2	Gene names	NSF
Domain Architecture
Description	Vesicle-fusing ATPase (EC 3.6.4.6) (Vesicular-fusion protein NSF) (N- ethylmaleimide sensitive fusion protein) (NEM-sensitive fusion protein).

YMEL1_HUMAN
NC score	0.908071 (rank : 33)	θ value	4.57862e-28 (rank : 39)
Query Neighborhood Hits	94	Target Neighborhood Hits	73	Shared Neighborhood Hits	61
SwissProt Accessions	Q96TA2, Q9H1Q0, Q9UMR9	Gene names	YME1L1, FTSH1, YME1L
Domain Architecture
Description	ATP-dependent metalloprotease YME1L1 (EC 3.4.24.-) (YME1-like protein 1) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin- associated metalloprotease) (PAMP).

SPAST_HUMAN
NC score	0.905286 (rank : 34)	θ value	5.77852e-31 (rank : 36)
Query Neighborhood Hits	94	Target Neighborhood Hits	100	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UBP0, Q9UPR9	Gene names	SPAST, KIAA1083, SPG4
Domain Architecture
Description	Spastin.

SPAST_MOUSE
NC score	0.904334 (rank : 35)	θ value	3.3877e-31 (rank : 33)
Query Neighborhood Hits	94	Target Neighborhood Hits	138	Shared Neighborhood Hits	60
SwissProt Accessions	Q9QYY8, Q6ZPY6, Q80VE0, Q9CVK0	Gene names	Spast, Kiaa1083, Spg4
Domain Architecture	No domain graphic available
Description	Spastin.

VPS4B_HUMAN
NC score	0.899840 (rank : 36)	θ value	4.42448e-31 (rank : 34)
Query Neighborhood Hits	94	Target Neighborhood Hits	87	Shared Neighborhood Hits	60
SwissProt Accessions	O75351, Q9GZS7	Gene names	VPS4B, SKD1, VPS42
Domain Architecture
Description	Vacuolar protein sorting-associating protein 4B (Protein SKD1).

VPS4B_MOUSE
NC score	0.899229 (rank : 37)	θ value	2.59387e-31 (rank : 32)
Query Neighborhood Hits	94	Target Neighborhood Hits	86	Shared Neighborhood Hits	60
SwissProt Accessions	P46467, Q91W22, Q9R1C9	Gene names	Vps4b, Skd1
Domain Architecture
Description	Vacuolar protein sorting-associating protein 4B (Protein SKD1).

VPS4A_HUMAN
NC score	0.897767 (rank : 38)	θ value	3.74554e-30 (rank : 37)
Query Neighborhood Hits	94	Target Neighborhood Hits	95	Shared Neighborhood Hits	62
SwissProt Accessions	Q9UN37, Q8TF07, Q9UI03, Q9Y582	Gene names	VPS4A, VPS4
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associating protein 4A (SKD2 protein) (hVPS4) (VPS4-1).

VPS4A_MOUSE
NC score	0.897766 (rank : 39)	θ value	3.74554e-30 (rank : 38)
Query Neighborhood Hits	94	Target Neighborhood Hits	94	Shared Neighborhood Hits	62
SwissProt Accessions	Q8VEJ9, Q3TXT2	Gene names	Vps4a
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associating protein 4A.

ATAD2_MOUSE
NC score	0.873893 (rank : 40)	θ value	2.12192e-33 (rank : 27)
Query Neighborhood Hits	94	Target Neighborhood Hits	167	Shared Neighborhood Hits	58
SwissProt Accessions	Q8CDM1	Gene names	Atad2
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 2.

FIGN_MOUSE
NC score	0.856532 (rank : 41)	θ value	3.17815e-21 (rank : 42)
Query Neighborhood Hits	94	Target Neighborhood Hits	165	Shared Neighborhood Hits	55
SwissProt Accessions	Q9ERZ6, Q3TPB0, Q3UP57, Q6PCM0	Gene names	Fign
Domain Architecture	No domain graphic available
Description	Fidgetin.

ATAD2_HUMAN
NC score	0.855770 (rank : 42)	θ value	1.79631e-32 (rank : 28)
Query Neighborhood Hits	94	Target Neighborhood Hits	322	Shared Neighborhood Hits	59
SwissProt Accessions	Q6PL18, Q658P2, Q68CQ0, Q6PJV6, Q8N890, Q9UHS5	Gene names	ATAD2
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 2.

FIGN_HUMAN
NC score	0.851313 (rank : 43)	θ value	5.42112e-21 (rank : 43)
Query Neighborhood Hits	94	Target Neighborhood Hits	176	Shared Neighborhood Hits	55
SwissProt Accessions	Q5HY92, Q9H6M5, Q9NVZ9	Gene names	FIGN
Domain Architecture	No domain graphic available
Description	Fidgetin.

TRP13_MOUSE
NC score	0.707141 (rank : 44)	θ value	3.41135e-07 (rank : 45)
Query Neighborhood Hits	94	Target Neighborhood Hits	81	Shared Neighborhood Hits	62
SwissProt Accessions	Q3UA06, Q3UQG6, Q9CWW8	Gene names	Trip13
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 13 (Thyroid hormone receptor interactor 13) (Trip-13).

TRP13_HUMAN
NC score	0.704661 (rank : 45)	θ value	3.41135e-07 (rank : 44)
Query Neighborhood Hits	94	Target Neighborhood Hits	81	Shared Neighborhood Hits	63
SwissProt Accessions	Q15645, O15324	Gene names	TRIP13
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 13 (Thyroid hormone receptor interactor 13) (Trip-13) (Human papillomavirus type 16 E1 protein- binding protein) (HPV16 E1 protein-binding protein) (16E1-BP).

BCS1_HUMAN
NC score	0.675928 (rank : 46)	θ value	5.81887e-07 (rank : 46)
Query Neighborhood Hits	94	Target Neighborhood Hits	61	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y276, Q7Z2V7	Gene names	BCS1L, BCS1
Domain Architecture
Description	Mitochondrial chaperone BCS1 (BCS1-like protein) (H-BCS1).

BCS1_MOUSE
NC score	0.665097 (rank : 47)	θ value	9.92553e-07 (rank : 47)
Query Neighborhood Hits	94	Target Neighborhood Hits	64	Shared Neighborhood Hits	54
SwissProt Accessions	Q9CZP5	Gene names	Bcs1l
Domain Architecture
Description	Mitochondrial chaperone BCS1 (BCS1-like protein).

ATD3A_HUMAN
NC score	0.586266 (rank : 48)	θ value	0.00134147 (rank : 50)
Query Neighborhood Hits	94	Target Neighborhood Hits	248	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NVI7, Q8N275, Q96A50	Gene names	ATAD3A
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3A.

ATD3B_HUMAN
NC score	0.575676 (rank : 49)	θ value	0.00228821 (rank : 51)
Query Neighborhood Hits	94	Target Neighborhood Hits	340	Shared Neighborhood Hits	61
SwissProt Accessions	Q5T9A4, Q6ZRB5, Q9BUK4, Q9ULE7	Gene names	ATAD3B, KIAA1273
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3B.

ATAD3_MOUSE
NC score	0.573162 (rank : 50)	θ value	9.29e-05 (rank : 48)
Query Neighborhood Hits	94	Target Neighborhood Hits	326	Shared Neighborhood Hits	62
SwissProt Accessions	Q925I1, Q3UE74, Q69ZM7, Q8C6C6	Gene names	Atad3, Atad3a, Kiaa1273
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3 (AAA-ATPase TOB3).

LONM_HUMAN
NC score	0.446344 (rank : 51)	θ value	0.000602161 (rank : 49)
Query Neighborhood Hits	94	Target Neighborhood Hits	130	Shared Neighborhood Hits	59
SwissProt Accessions	P36776, P36777, Q9UQ95	Gene names	PRSS15
Domain Architecture
Description	Lon protease homolog, mitochondrial precursor (EC 3.4.21.-) (Lon protease-like protein) (LONP) (LONHs).

CLPX_HUMAN
NC score	0.431575 (rank : 52)	θ value	0.00298849 (rank : 52)
Query Neighborhood Hits	94	Target Neighborhood Hits	72	Shared Neighborhood Hits	53
SwissProt Accessions	O76031, Q9H4D9	Gene names	CLPX
Domain Architecture
Description	ATP-dependent Clp protease ATP-binding subunit ClpX-like, mitochondrial precursor.

CLPX_MOUSE
NC score	0.429376 (rank : 53)	θ value	0.00298849 (rank : 53)
Query Neighborhood Hits	94	Target Neighborhood Hits	73	Shared Neighborhood Hits	53
SwissProt Accessions	Q9JHS4, Q9WVD1	Gene names	Clpx
Domain Architecture
Description	ATP-dependent Clp protease ATP-binding subunit ClpX-like, mitochondrial precursor.

RUVB1_HUMAN
NC score	0.312767 (rank : 54)	θ value	0.125558 (rank : 56)
Query Neighborhood Hits	94	Target Neighborhood Hits	78	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y265, Q9BSX9	Gene names	RUVBL1, NMP238, TIP49, TIP49A
Domain Architecture
Description	RuvB-like 1 (EC 3.6.1.-) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (TIP49a) (Pontin 52) (Nuclear matrix protein 238) (NMP 238) (54 kDa erythrocyte cytosolic protein) (ECP-54) (TIP60-associated protein 54-alpha) (TAP54-alpha).

RUVB1_MOUSE
NC score	0.312727 (rank : 55)	θ value	0.125558 (rank : 57)
Query Neighborhood Hits	94	Target Neighborhood Hits	78	Shared Neighborhood Hits	65
SwissProt Accessions	P60122, O35753	Gene names	Ruvbl1, Tip49, Tip49a
Domain Architecture
Description	RuvB-like 1 (EC 3.6.1.-) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (TIP49a) (Pontin 52) (DNA helicase p50).

WRIP1_HUMAN
NC score	0.220826 (rank : 56)	θ value	4.03905 (rank : 83)
Query Neighborhood Hits	94	Target Neighborhood Hits	100	Shared Neighborhood Hits	56
SwissProt Accessions	Q96S55, Q53EP6, Q59ET8, Q5W0E2, Q5W0E4, Q8WV26, Q9H681, Q9NRJ6	Gene names	WRNIP1, WHIP
Domain Architecture	No domain graphic available
Description	ATPase WRNIP1 (Werner helicase-interacting protein 1).

WRIP1_MOUSE
NC score	0.220441 (rank : 57)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	94	Target Neighborhood Hits	93	Shared Neighborhood Hits	57
SwissProt Accessions	Q91XU0, Q3TCT7, Q6PDF0, Q8BUW5, Q8BWP6, Q8BY55, Q921W3, Q9EQL3	Gene names	Wrnip1, Whip
Domain Architecture	No domain graphic available
Description	ATPase WRNIP1 (Werner helicase-interacting protein 1).

RFC1_MOUSE
NC score	0.146940 (rank : 58)	θ value	0.125558 (rank : 55)
Query Neighborhood Hits	94	Target Neighborhood Hits	290	Shared Neighborhood Hits	50
SwissProt Accessions	P35601	Gene names	Rfc1, Ibf-1, Recc1
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (A1-P145) (Differentiation- specific element-binding protein) (ISRE-binding protein).

RFC1_HUMAN
NC score	0.132663 (rank : 59)	θ value	0.279714 (rank : 59)
Query Neighborhood Hits	94	Target Neighborhood Hits	352	Shared Neighborhood Hits	47
SwissProt Accessions	P35251, Q5XKF5, Q6PKU0, Q86V41, Q86V46	Gene names	RFC1, RFC140
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (DNA-binding protein PO-GA).

RFC4_HUMAN
NC score	0.127590 (rank : 60)	θ value	0.279714 (rank : 60)
Query Neighborhood Hits	94	Target Neighborhood Hits	64	Shared Neighborhood Hits	42
SwissProt Accessions	P35249, Q6FHX7	Gene names	RFC4
Domain Architecture
Description	Replication factor C subunit 4 (Replication factor C 37 kDa subunit) (RF-C 37 kDa subunit) (RFC37) (Activator 1 37 kDa subunit) (A1 37 kDa subunit).

THNSL_MOUSE
NC score	0.123854 (rank : 61)	θ value	0.813845 (rank : 64)
Query Neighborhood Hits	94	Target Neighborhood Hits	47	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BH55	Gene names	Thnsl1
Domain Architecture	No domain graphic available
Description	Threonine synthase-like 1.

THNSL_HUMAN
NC score	0.122821 (rank : 62)	θ value	0.62314 (rank : 62)
Query Neighborhood Hits	94	Target Neighborhood Hits	47	Shared Neighborhood Hits	37
SwissProt Accessions	Q8IYQ7, Q5VV21	Gene names	THNSL1
Domain Architecture	No domain graphic available
Description	Threonine synthase-like 1.

RFC4_MOUSE
NC score	0.113732 (rank : 63)	θ value	1.06291 (rank : 65)
Query Neighborhood Hits	94	Target Neighborhood Hits	65	Shared Neighborhood Hits	42
SwissProt Accessions	Q99J62	Gene names	Rfc4
Domain Architecture	No domain graphic available
Description	Replication factor C subunit 4.

RUVB2_HUMAN
NC score	0.113528 (rank : 64)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	94	Target Neighborhood Hits	43	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y230, Q6PK27, Q9Y361	Gene names	RUVBL2, TIP48, TIP49B
Domain Architecture
Description	RuvB-like 2 (EC 3.6.1.-) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (TIP49b) (Repressing pontin 52) (Reptin 52) (51 kDa erythrocyte cytosolic protein) (ECP-51) (TIP60-associated protein 54-beta) (TAP54-beta).

KAD6_HUMAN
NC score	0.113321 (rank : 65)	θ value	4.03905 (rank : 79)
Query Neighborhood Hits	94	Target Neighborhood Hits	46	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y3D8	Gene names	AK6
Domain Architecture
Description	Adenylate kinase isoenzyme 6 (EC 2.7.4.3) (ATP-AMP transphosphorylase 6).

RUVB2_MOUSE
NC score	0.110884 (rank : 66)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	94	Target Neighborhood Hits	42	Shared Neighborhood Hits	37
SwissProt Accessions	Q9WTM5	Gene names	Ruvbl2
Domain Architecture
Description	RuvB-like 2 (EC 3.6.1.-) (p47 protein).

KAD6_MOUSE
NC score	0.090208 (rank : 67)	θ value	5.27518 (rank : 86)
Query Neighborhood Hits	94	Target Neighborhood Hits	34	Shared Neighborhood Hits	21
SwissProt Accessions	Q8VCP8	Gene names	Ak6
Domain Architecture	No domain graphic available
Description	Adenylate kinase isoenzyme 6 (EC 2.7.4.3) (ATP-AMP transphosphorylase 6).

RFC5_MOUSE
NC score	0.077258 (rank : 68)	θ value	6.88961 (rank : 88)
Query Neighborhood Hits	94	Target Neighborhood Hits	58	Shared Neighborhood Hits	38
SwissProt Accessions	Q9D0F6	Gene names	Rfc5
Domain Architecture
Description	Replication factor C subunit 5 (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36) (Activator 1 36 kDa subunit) (A1 36 kDa subunit).

RFC5_HUMAN
NC score	0.076538 (rank : 69)	θ value	6.88961 (rank : 87)
Query Neighborhood Hits	94	Target Neighborhood Hits	60	Shared Neighborhood Hits	36
SwissProt Accessions	P40937	Gene names	RFC5
Domain Architecture
Description	Replication factor C subunit 5 (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36) (Activator 1 36 kDa subunit) (A1 36 kDa subunit).

RAD17_MOUSE
NC score	0.067164 (rank : 70)	θ value	1.81305 (rank : 72)
Query Neighborhood Hits	94	Target Neighborhood Hits	63	Shared Neighborhood Hits	29
SwissProt Accessions	Q6NXW6, O88934, O89024	Gene names	Rad17
Domain Architecture	No domain graphic available
Description	Cell cycle checkpoint protein RAD17.

RFC2_HUMAN
NC score	0.055092 (rank : 71)	θ value	8.99809 (rank : 92)
Query Neighborhood Hits	94	Target Neighborhood Hits	46	Shared Neighborhood Hits	25
SwissProt Accessions	P35250, P32846, Q9BU93	Gene names	RFC2
Domain Architecture
Description	Replication factor C subunit 2 (Replication factor C 40 kDa subunit) (RF-C 40 kDa subunit) (RFC40) (Activator 1 40 kDa subunit) (A1 40 kDa subunit).

RFC2_MOUSE
NC score	0.052667 (rank : 72)	θ value	8.99809 (rank : 93)
Query Neighborhood Hits	94	Target Neighborhood Hits	46	Shared Neighborhood Hits	25
SwissProt Accessions	Q9WUK4	Gene names	Rfc2
Domain Architecture
Description	Replication factor C subunit 2 (Replication factor C 40 kDa subunit) (RF-C 40 kDa subunit) (RFC40) (Activator 1 40 kDa subunit) (A1 40 kDa subunit).

SMBP2_MOUSE
NC score	0.048294 (rank : 73)	θ value	0.0252991 (rank : 54)
Query Neighborhood Hits	94	Target Neighborhood Hits	104	Shared Neighborhood Hits	12
SwissProt Accessions	P40694	Gene names	Ighmbp2, Smbp-2, Smbp2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Cardiac transcription factor 1) (CATF1).

AQR_MOUSE
NC score	0.046830 (rank : 74)	θ value	1.81305 (rank : 70)
Query Neighborhood Hits	94	Target Neighborhood Hits	62	Shared Neighborhood Hits	15
SwissProt Accessions	Q8CFQ3, P97871, Q3U9N1, Q3ULE8, Q80TX8	Gene names	Aqr, Kiaa0560
Domain Architecture	No domain graphic available
Description	Intron-binding protein aquarius.

AQR_HUMAN
NC score	0.046157 (rank : 75)	θ value	1.81305 (rank : 69)
Query Neighborhood Hits	94	Target Neighborhood Hits	88	Shared Neighborhood Hits	16
SwissProt Accessions	O60306, Q2YDX9, Q6IRU8, Q6PIC8	Gene names	AQR, KIAA0560
Domain Architecture	No domain graphic available
Description	Intron-binding protein aquarius (Intron-binding protein of 160 kDa) (IBP160).

SMBP2_HUMAN
NC score	0.040569 (rank : 76)	θ value	0.365318 (rank : 61)
Query Neighborhood Hits	94	Target Neighborhood Hits	107	Shared Neighborhood Hits	11
SwissProt Accessions	P38935, Q00443, Q14177	Gene names	IGHMBP2, SMBP2, SMUBP2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Glial factor 1) (GF-1).

TOR1B_HUMAN
NC score	0.024666 (rank : 77)	θ value	0.62314 (rank : 63)
Query Neighborhood Hits	94	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	O14657	Gene names	TOR1B, DQ1
Domain Architecture
Description	Torsin B precursor (Torsin family 1 member B).

MRE11_MOUSE
NC score	0.023596 (rank : 78)	θ value	0.21417 (rank : 58)
Query Neighborhood Hits	94	Target Neighborhood Hits	137	Shared Neighborhood Hits	2
SwissProt Accessions	Q61216, Q62430	Gene names	Mre11a, Mre11
Domain Architecture
Description	Double-strand break repair protein MRE11A (MRE11 homolog 1) (MRE11 meiotic recombination 11 homolog A) (MmMRE11A).

TOR1B_MOUSE
NC score	0.022875 (rank : 79)	θ value	1.06291 (rank : 66)
Query Neighborhood Hits	94	Target Neighborhood Hits	13	Shared Neighborhood Hits	4
SwissProt Accessions	Q9ER41	Gene names	Tor1b
Domain Architecture
Description	Torsin B precursor (Torsin family 1 member B).

ZNFX1_HUMAN
NC score	0.020474 (rank : 80)	θ value	1.38821 (rank : 68)
Query Neighborhood Hits	94	Target Neighborhood Hits	308	Shared Neighborhood Hits	10
SwissProt Accessions	Q9P2E3, Q9BQM7, Q9BQM8, Q9H8C1, Q9H9S2, Q9NUM1, Q9NWW1	Gene names	ZNFX1, KIAA1404
Domain Architecture	No domain graphic available
Description	NFX1-type zinc finger-containing protein 1.

NALP7_HUMAN
NC score	0.020059 (rank : 81)	θ value	1.38821 (rank : 67)
Query Neighborhood Hits	94	Target Neighborhood Hits	65	Shared Neighborhood Hits	14
SwissProt Accessions	Q8WX94, Q7RTR1	Gene names	NALP7, NOD12, PYPAF3
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 7 (PYRIN-containing APAF1-like protein 3).

CNKR1_HUMAN
NC score	0.011332 (rank : 82)	θ value	2.36792 (rank : 73)
Query Neighborhood Hits	94	Target Neighborhood Hits	154	Shared Neighborhood Hits	2
SwissProt Accessions	Q969H4, O95381	Gene names	CNKSR1, CNK1
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 1 (Connector enhancer of KSR1) (hCNK1) (Connector enhancer of KSR-like) (CNK homolog protein 1).

NALP5_MOUSE
NC score	0.010892 (rank : 83)	θ value	4.03905 (rank : 80)
Query Neighborhood Hits	94	Target Neighborhood Hits	560	Shared Neighborhood Hits	12
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

GALK2_MOUSE
NC score	0.010063 (rank : 84)	θ value	4.03905 (rank : 78)
Query Neighborhood Hits	94	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q68FH4	Gene names	Galk2
Domain Architecture	No domain graphic available
Description	N-acetylgalactosamine kinase (EC 2.7.1.157) (GalNAc kinase) (Galactokinase 2).

CRSP7_HUMAN
NC score	0.009697 (rank : 85)	θ value	4.03905 (rank : 77)
Query Neighborhood Hits	94	Target Neighborhood Hits	247	Shared Neighborhood Hits	3
SwissProt Accessions	O95402	Gene names	CRSP7, ARC70
Domain Architecture
Description	CRSP complex subunit 7 (Cofactor required for Sp1 transcriptional activation subunit 7) (Transcriptional coactivator CRSP70) (Activator- recruited cofactor 70 kDa component) (ARC70).

PARC_HUMAN
NC score	0.007363 (rank : 86)	θ value	2.36792 (rank : 74)
Query Neighborhood Hits	94	Target Neighborhood Hits	148	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IWT3, O75188, Q68CP2, Q68D92, Q8N3W9, Q9BU56	Gene names	PARC, H7AP1, KIAA0708
Domain Architecture
Description	p53-associated parkin-like cytoplasmic protein (UbcH7-associated protein 1).

CO4A_HUMAN
NC score	0.007108 (rank : 87)	θ value	5.27518 (rank : 84)
Query Neighborhood Hits	94	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	P0C0L4, P01028, P78445, Q13160, Q13906, Q14033, Q14835, Q5JQM8, Q9NPK5, Q9UIP5	Gene names	C4A
Domain Architecture	No domain graphic available
Description	Complement C4-A precursor (Acidic complement C4) [Contains: Complement C4 beta chain; Complement C4-A alpha chain; C4a anaphylatoxin; C4b-A; C4d-A; Complement C4 gamma chain].

CO4B_HUMAN
NC score	0.007104 (rank : 88)	θ value	5.27518 (rank : 85)
Query Neighborhood Hits	94	Target Neighborhood Hits	47	Shared Neighborhood Hits	4
SwissProt Accessions	P0C0L5, P01028, P78445, Q13160, Q13906, Q14033, Q14835, Q9NPK5, Q9UIP5	Gene names	C4B
Domain Architecture	No domain graphic available
Description	Complement C4-B precursor (Basic complement C4) [Contains: Complement C4 beta chain; Complement C4-B alpha chain; C4a anaphylatoxin; C4b-B; C4d-B; Complement C4 gamma chain].

TSC2_HUMAN
NC score	0.004558 (rank : 89)	θ value	8.99809 (rank : 94)
Query Neighborhood Hits	94	Target Neighborhood Hits	59	Shared Neighborhood Hits	2
SwissProt Accessions	P49815, O75275, Q8TAZ1	Gene names	TSC2
Domain Architecture
Description	Tuberin (Tuberous sclerosis 2 protein).

BIRC1_HUMAN
NC score	0.004169 (rank : 90)	θ value	8.99809 (rank : 89)
Query Neighborhood Hits	94	Target Neighborhood Hits	61	Shared Neighborhood Hits	5
SwissProt Accessions	Q13075, O75857, Q13730, Q99796	Gene names	BIRC1, NAIP
Domain Architecture
Description	Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein).

PO3F3_HUMAN
NC score	0.003433 (rank : 91)	θ value	4.03905 (rank : 81)
Query Neighborhood Hits	94	Target Neighborhood Hits	311	Shared Neighborhood Hits	3
SwissProt Accessions	P20264, P78379	Gene names	POU3F3, BRN1, OTF8
Domain Architecture
Description	POU domain, class 3, transcription factor 3 (Brain-specific homeobox/POU domain protein 1) (Brain-1) (Brn-1 protein).

PO3F3_MOUSE
NC score	0.003429 (rank : 92)	θ value	4.03905 (rank : 82)
Query Neighborhood Hits	94	Target Neighborhood Hits	308	Shared Neighborhood Hits	3
SwissProt Accessions	P31361	Gene names	Pou3f3, Brn-1, Brn1, Otf8
Domain Architecture
Description	POU domain, class 3, transcription factor 3 (Brain-specific homeobox/POU domain protein 1) (Brain-1) (Brn-1 protein).

IRF3_HUMAN
NC score	0.002991 (rank : 93)	θ value	8.99809 (rank : 90)
Query Neighborhood Hits	94	Target Neighborhood Hits	129	Shared Neighborhood Hits	3
SwissProt Accessions	Q14653	Gene names	IRF3
Domain Architecture
Description	Interferon regulatory factor 3 (IRF-3).

MUC5B_HUMAN
NC score	0.002629 (rank : 94)	θ value	1.81305 (rank : 71)
Query Neighborhood Hits	94	Target Neighborhood Hits	1020	Shared Neighborhood Hits	6
SwissProt Accessions	Q9HC84, O00447, O00573, O14985, O15494, O95291, O95451, Q14881, Q99552, Q9UE28	Gene names	MUC5B, MUC5
Domain Architecture
Description	Mucin-5B precursor (Mucin-5 subtype B, tracheobronchial) (High molecular weight salivary mucin MG1) (Sublingual gland mucin).

COT1_HUMAN
NC score	0.002270 (rank : 95)	θ value	3.0926 (rank : 75)
Query Neighborhood Hits	94	Target Neighborhood Hits	159	Shared Neighborhood Hits	3
SwissProt Accessions	P10589	Gene names	NR2F1, EAR3, ERBAL3, TFCOUP1
Domain Architecture
Description	COUP transcription factor 1 (COUP-TF1) (COUP-TF I) (V-ERBA-related protein EAR-3).

COT1_MOUSE
NC score	0.002046 (rank : 96)	θ value	4.03905 (rank : 76)
Query Neighborhood Hits	94	Target Neighborhood Hits	160	Shared Neighborhood Hits	3
SwissProt Accessions	Q60632, Q61438	Gene names	Nr2f1, Erbal3, Tfcoup1
Domain Architecture
Description	COUP transcription factor 1 (COUP-TF1) (COUP-TF I).

PTN14_HUMAN
NC score	-0.000412 (rank : 97)	θ value	8.99809 (rank : 91)
Query Neighborhood Hits	94	Target Neighborhood Hits	163	Shared Neighborhood Hits	2
SwissProt Accessions	Q15678	Gene names	PTPN14, PEZ
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 14 (EC 3.1.3.48) (Protein-tyrosine phosphatase pez).