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Network neighborhood for query Sequence : PRS8_MOUSE

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PRS8_MOUSE
SwissProt Accessions	P62196, O35051, P47210, P52915, P52916, Q3UL51, Q9CWN5	Gene names	Psmc5, Sug1
Domain Architecture
Description	26S protease regulatory subunit 8 (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (p45/SUG) (mSUG1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PRS8_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	117	Target Neighborhood Hits	117	Shared Neighborhood Hits	117
SwissProt Accessions	P62195, O35051, O43208, P47210, P52915, P52916	Gene names	PSMC5, SUG1
Domain Architecture
Description	26S protease regulatory subunit 8 (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (p45/SUG) (Thyroid hormone receptor- interacting protein 1) (TRIP1).

PRS8_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 2)
Query Neighborhood Hits	117	Target Neighborhood Hits	117	Shared Neighborhood Hits	117
SwissProt Accessions	P62196, O35051, P47210, P52915, P52916, Q3UL51, Q9CWN5	Gene names	Psmc5, Sug1
Domain Architecture
Description	26S protease regulatory subunit 8 (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (p45/SUG) (mSUG1).

PRS4_HUMAN
θ value	3.32542e-95 (rank : 3)	NC score	0.989284 (rank : 3)
Query Neighborhood Hits	117	Target Neighborhood Hits	84	Shared Neighborhood Hits	66
SwissProt Accessions	P62191, P49014, Q03527, Q6IAW0, Q96AZ3	Gene names	PSMC1
Domain Architecture
Description	26S protease regulatory subunit 4 (P26s4) (Proteasome 26S subunit ATPase 1).

PRS4_MOUSE
θ value	3.32542e-95 (rank : 4)	NC score	0.989284 (rank : 4)
Query Neighborhood Hits	117	Target Neighborhood Hits	84	Shared Neighborhood Hits	66
SwissProt Accessions	P62192, P49014, Q03527, Q96AZ3	Gene names	Psmc1
Domain Architecture
Description	26S protease regulatory subunit 4 (P26s4) (Proteasome 26S subunit ATPase 1).

PRS10_HUMAN
θ value	1.30768e-91 (rank : 5)	NC score	0.988802 (rank : 5)
Query Neighborhood Hits	117	Target Neighborhood Hits	95	Shared Neighborhood Hits	66
SwissProt Accessions	P62333, P49719, Q6IBU3, Q92524	Gene names	PSMC6, SUG2
Domain Architecture
Description	26S protease regulatory subunit S10B (Proteasome subunit p42) (Proteasome 26S subunit ATPase 6).

PRS10_MOUSE
θ value	1.30768e-91 (rank : 6)	NC score	0.988802 (rank : 6)
Query Neighborhood Hits	117	Target Neighborhood Hits	95	Shared Neighborhood Hits	66
SwissProt Accessions	P62334, P49719, Q3TKK1, Q810A6, Q92524, Q9CXH9	Gene names	Psmc6, Sug2
Domain Architecture
Description	26S protease regulatory subunit S10B (Proteasome subunit p42) (Proteasome 26S subunit ATPase 6).

PRS7_HUMAN
θ value	1.70789e-91 (rank : 7)	NC score	0.988194 (rank : 7)
Query Neighborhood Hits	117	Target Neighborhood Hits	66	Shared Neighborhood Hits	62
SwissProt Accessions	P35998	Gene names	PSMC2, MSS1
Domain Architecture
Description	26S protease regulatory subunit 7 (Proteasome 26S subunit ATPase 2) (Protein MSS1).

PRS7_MOUSE
θ value	1.70789e-91 (rank : 8)	NC score	0.988182 (rank : 8)
Query Neighborhood Hits	117	Target Neighborhood Hits	67	Shared Neighborhood Hits	62
SwissProt Accessions	P46471, O08531, Q3TGX5, Q9DBA1	Gene names	Psmc2, Mss1
Domain Architecture
Description	26S protease regulatory subunit 7 (Proteasome 26S subunit ATPase 2) (Protein MSS1).

PRS6A_HUMAN
θ value	2.16048e-86 (rank : 9)	NC score	0.985212 (rank : 10)
Query Neighborhood Hits	117	Target Neighborhood Hits	87	Shared Neighborhood Hits	61
SwissProt Accessions	P17980, Q96HD3	Gene names	PSMC3, TBP1
Domain Architecture
Description	26S protease regulatory subunit 6A (Proteasome 26S subunit ATPase 3) (TAT-binding protein 1) (TBP-1) (Proteasome subunit P50).

PRS6A_MOUSE
θ value	1.40038e-85 (rank : 10)	NC score	0.985299 (rank : 9)
Query Neighborhood Hits	117	Target Neighborhood Hits	85	Shared Neighborhood Hits	61
SwissProt Accessions	O88685	Gene names	Psmc3, Tbp1
Domain Architecture
Description	26S protease regulatory subunit 6A (Proteasome 26S subunit ATPase 3) (TAT-binding protein 1) (TBP-1).

PRS6B_HUMAN
θ value	5.50685e-82 (rank : 11)	NC score	0.983677 (rank : 11)
Query Neighborhood Hits	117	Target Neighborhood Hits	85	Shared Neighborhood Hits	57
SwissProt Accessions	P43686, Q96FV5, Q9UBM3, Q9UEX3	Gene names	PSMC4, TBP7
Domain Architecture
Description	26S protease regulatory subunit 6B (Proteasome 26S subunit ATPase 4) (MIP224) (MB67-interacting protein) (TAT-binding protein 7) (TBP-7).

PRS6B_MOUSE
θ value	3.94648e-80 (rank : 12)	NC score	0.983187 (rank : 12)
Query Neighborhood Hits	117	Target Neighborhood Hits	89	Shared Neighborhood Hits	57
SwissProt Accessions	P54775	Gene names	Psmc4, Tbp7
Domain Architecture
Description	26S protease regulatory subunit 6B (Proteasome 26S subunit ATPase 4) (MIP224) (MB67-interacting protein) (TAT-binding protein 7) (TBP-7) (CIP21).

AFG32_HUMAN
θ value	4.39379e-55 (rank : 13)	NC score	0.948406 (rank : 18)
Query Neighborhood Hits	117	Target Neighborhood Hits	72	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Y4W6	Gene names	AFG3L2
Domain Architecture
Description	AFG3-like protein 2 (EC 3.4.24.-) (Paraplegin-like protein).

AFG32_MOUSE
θ value	7.49467e-55 (rank : 14)	NC score	0.948189 (rank : 19)
Query Neighborhood Hits	117	Target Neighborhood Hits	73	Shared Neighborhood Hits	61
SwissProt Accessions	Q8JZQ2	Gene names	Afg3l2
Domain Architecture	No domain graphic available
Description	AFG3-like protein 2 (EC 3.4.24.-).

AFG31_MOUSE
θ value	1.41344e-53 (rank : 15)	NC score	0.951936 (rank : 15)
Query Neighborhood Hits	117	Target Neighborhood Hits	74	Shared Neighborhood Hits	61
SwissProt Accessions	Q920A7	Gene names	Afg3l1
Domain Architecture
Description	AFG3-like protein 1 (EC 3.4.24.-).

TERA_HUMAN
θ value	6.56568e-51 (rank : 16)	NC score	0.952650 (rank : 13)
Query Neighborhood Hits	117	Target Neighborhood Hits	76	Shared Neighborhood Hits	64
SwissProt Accessions	P55072, Q969G7	Gene names	VCP
Domain Architecture
Description	Transitional endoplasmic reticulum ATPase (TER ATPase) (15S Mg(2+)- ATPase p97 subunit) (Valosin-containing protein) (VCP).

TERA_MOUSE
θ value	6.56568e-51 (rank : 17)	NC score	0.952621 (rank : 14)
Query Neighborhood Hits	117	Target Neighborhood Hits	76	Shared Neighborhood Hits	64
SwissProt Accessions	Q01853	Gene names	Vcp
Domain Architecture
Description	Transitional endoplasmic reticulum ATPase (TER ATPase) (15S Mg(2+)- ATPase p97 subunit) (Valosin-containing protein) (VCP).

SPG7_HUMAN
θ value	3.37202e-47 (rank : 18)	NC score	0.950531 (rank : 16)
Query Neighborhood Hits	117	Target Neighborhood Hits	71	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UQ90, O75756, Q96IB0	Gene names	SPG7, CAR, CMAR, PGN
Domain Architecture
Description	Paraplegin (EC 3.4.24.-) (Spastic paraplegia protein 7).

PEX6_HUMAN
θ value	2.18568e-46 (rank : 19)	NC score	0.938358 (rank : 26)
Query Neighborhood Hits	117	Target Neighborhood Hits	99	Shared Neighborhood Hits	64
SwissProt Accessions	Q13608, Q8WYQ2, Q99476	Gene names	PEX6, PXAAA1
Domain Architecture
Description	Peroxisome assembly factor 2 (PAF-2) (Peroxisomal-type ATPase 1) (Peroxin-6) (Peroxisomal biogenesis factor 6).

YMEL1_MOUSE
θ value	3.72821e-46 (rank : 20)	NC score	0.943618 (rank : 20)
Query Neighborhood Hits	117	Target Neighborhood Hits	76	Shared Neighborhood Hits	58
SwissProt Accessions	O88967, Q7TNN5	Gene names	Yme1l1
Domain Architecture
Description	ATP-dependent metalloprotease YME1L1 (EC 3.4.24.-) (YME1-like protein 1) (ATP-dependent metalloprotease FtsH1).

YMEL1_HUMAN
θ value	6.35935e-46 (rank : 21)	NC score	0.940047 (rank : 24)
Query Neighborhood Hits	117	Target Neighborhood Hits	73	Shared Neighborhood Hits	58
SwissProt Accessions	Q96TA2, Q9H1Q0, Q9UMR9	Gene names	YME1L1, FTSH1, YME1L
Domain Architecture
Description	ATP-dependent metalloprotease YME1L1 (EC 3.4.24.-) (YME1-like protein 1) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin- associated metalloprotease) (PAMP).

PEX6_MOUSE
θ value	3.15612e-45 (rank : 22)	NC score	0.938122 (rank : 27)
Query Neighborhood Hits	117	Target Neighborhood Hits	94	Shared Neighborhood Hits	61
SwissProt Accessions	Q99LC9, Q6YNQ9	Gene names	Pex6
Domain Architecture	No domain graphic available
Description	Peroxisome assembly factor 2 (PAF-2) (Peroxisomal-type ATPase 1) (Peroxin-6) (Peroxisomal biogenesis factor 6).

PEX1_HUMAN
θ value	2.04573e-44 (rank : 23)	NC score	0.949876 (rank : 17)
Query Neighborhood Hits	117	Target Neighborhood Hits	98	Shared Neighborhood Hits	62
SwissProt Accessions	O43933, Q96S71, Q96S72, Q96S73, Q99994	Gene names	PEX1
Domain Architecture
Description	Peroxisome biogenesis factor 1 (Peroxin-1) (Peroxisome biogenesis disorder protein 1).

ATAD2_HUMAN
θ value	2.67181e-44 (rank : 24)	NC score	0.879506 (rank : 41)
Query Neighborhood Hits	117	Target Neighborhood Hits	322	Shared Neighborhood Hits	62
SwissProt Accessions	Q6PL18, Q658P2, Q68CQ0, Q6PJV6, Q8N890, Q9UHS5	Gene names	ATAD2
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 2.

ATAD2_MOUSE
θ value	1.73182e-43 (rank : 25)	NC score	0.896276 (rank : 40)
Query Neighborhood Hits	117	Target Neighborhood Hits	167	Shared Neighborhood Hits	57
SwissProt Accessions	Q8CDM1	Gene names	Atad2
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 2.

KTNA1_HUMAN
θ value	1.2411e-41 (rank : 26)	NC score	0.927278 (rank : 30)
Query Neighborhood Hits	117	Target Neighborhood Hits	117	Shared Neighborhood Hits	63
SwissProt Accessions	O75449, Q5TFA8, Q5TFA9, Q86VN2, Q9NU52	Gene names	KATNA1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A1 (EC 3.6.4.3) (Katanin p60 subunit A1) (p60 katanin).

KTNA1_MOUSE
θ value	2.76489e-41 (rank : 27)	NC score	0.925077 (rank : 33)
Query Neighborhood Hits	117	Target Neighborhood Hits	123	Shared Neighborhood Hits	63
SwissProt Accessions	Q9WV86	Gene names	Katna1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A1 (EC 3.6.4.3) (Katanin p60 subunit A1) (p60 katanin) (Lipotransin).

KATL1_HUMAN
θ value	3.61106e-41 (rank : 28)	NC score	0.930187 (rank : 28)
Query Neighborhood Hits	117	Target Neighborhood Hits	80	Shared Neighborhood Hits	64
SwissProt Accessions	Q9BW62	Gene names	KATNAL1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A-like 1 (EC 3.6.4.3) (Katanin p60 subunit A-like 1) (p60 katanin-like 1).

NVL_HUMAN
θ value	3.61106e-41 (rank : 29)	NC score	0.939766 (rank : 25)
Query Neighborhood Hits	117	Target Neighborhood Hits	112	Shared Neighborhood Hits	67
SwissProt Accessions	O15381, Q96EM7	Gene names	NVL
Domain Architecture
Description	Nuclear valosin-containing protein-like (Nuclear VCP-like protein) (NVLp).

NVL_MOUSE
θ value	1.05066e-40 (rank : 30)	NC score	0.940233 (rank : 23)
Query Neighborhood Hits	117	Target Neighborhood Hits	110	Shared Neighborhood Hits	66
SwissProt Accessions	Q9DBY8, Q3USC4, Q8BW27, Q8K2B5	Gene names	Nvl
Domain Architecture
Description	Nuclear valosin-containing protein-like (Nuclear VCP-like protein) (NVLp).

KATL1_MOUSE
θ value	1.51715e-39 (rank : 31)	NC score	0.929876 (rank : 29)
Query Neighborhood Hits	117	Target Neighborhood Hits	77	Shared Neighborhood Hits	64
SwissProt Accessions	Q8K0T4	Gene names	Katnal1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A-like 1 (EC 3.6.4.3) (Katanin p60 subunit A-like 1) (p60 katanin-like 1).

NSF_HUMAN
θ value	2.05049e-36 (rank : 32)	NC score	0.926538 (rank : 32)
Query Neighborhood Hits	117	Target Neighborhood Hits	74	Shared Neighborhood Hits	63
SwissProt Accessions	P46459, Q9UKZ2	Gene names	NSF
Domain Architecture
Description	Vesicle-fusing ATPase (EC 3.6.4.6) (Vesicular-fusion protein NSF) (N- ethylmaleimide sensitive fusion protein) (NEM-sensitive fusion protein).

NSF_MOUSE
θ value	3.4976e-36 (rank : 33)	NC score	0.926847 (rank : 31)
Query Neighborhood Hits	117	Target Neighborhood Hits	73	Shared Neighborhood Hits	61
SwissProt Accessions	P46460	Gene names	Nsf, Skd2
Domain Architecture
Description	Vesicle-fusing ATPase (EC 3.6.4.6) (Vesicular-fusion protein NSF) (N- ethylmaleimide sensitive fusion protein) (NEM-sensitive fusion protein) (SKD2 protein).

SPAST_HUMAN
θ value	1.12514e-34 (rank : 34)	NC score	0.920727 (rank : 34)
Query Neighborhood Hits	117	Target Neighborhood Hits	100	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UBP0, Q9UPR9	Gene names	SPAST, KIAA1083, SPG4
Domain Architecture
Description	Spastin.

SPAST_MOUSE
θ value	1.12514e-34 (rank : 35)	NC score	0.919217 (rank : 35)
Query Neighborhood Hits	117	Target Neighborhood Hits	138	Shared Neighborhood Hits	61
SwissProt Accessions	Q9QYY8, Q6ZPY6, Q80VE0, Q9CVK0	Gene names	Spast, Kiaa1083, Spg4
Domain Architecture	No domain graphic available
Description	Spastin.

ATAD1_HUMAN
θ value	1.46948e-34 (rank : 36)	NC score	0.940978 (rank : 21)
Query Neighborhood Hits	117	Target Neighborhood Hits	75	Shared Neighborhood Hits	62
SwissProt Accessions	Q8NBU5, Q6P4B9, Q8N3G1, Q8WYR9, Q969Y3	Gene names	ATAD1
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 1.

ATAD1_MOUSE
θ value	1.46948e-34 (rank : 37)	NC score	0.940978 (rank : 22)
Query Neighborhood Hits	117	Target Neighborhood Hits	75	Shared Neighborhood Hits	62
SwissProt Accessions	Q9D5T0, Q3U8V2, Q9D7A4	Gene names	Atad1
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 1.

VPS4A_HUMAN
θ value	2.77131e-33 (rank : 38)	NC score	0.909272 (rank : 38)
Query Neighborhood Hits	117	Target Neighborhood Hits	95	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UN37, Q8TF07, Q9UI03, Q9Y582	Gene names	VPS4A, VPS4
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associating protein 4A (SKD2 protein) (hVPS4) (VPS4-1).

VPS4A_MOUSE
θ value	2.77131e-33 (rank : 39)	NC score	0.909253 (rank : 39)
Query Neighborhood Hits	117	Target Neighborhood Hits	94	Shared Neighborhood Hits	61
SwissProt Accessions	Q8VEJ9, Q3TXT2	Gene names	Vps4a
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associating protein 4A.

VPS4B_HUMAN
θ value	4.00176e-32 (rank : 40)	NC score	0.911554 (rank : 36)
Query Neighborhood Hits	117	Target Neighborhood Hits	87	Shared Neighborhood Hits	61
SwissProt Accessions	O75351, Q9GZS7	Gene names	VPS4B, SKD1, VPS42
Domain Architecture
Description	Vacuolar protein sorting-associating protein 4B (Protein SKD1).

VPS4B_MOUSE
θ value	1.52067e-31 (rank : 41)	NC score	0.911029 (rank : 37)
Query Neighborhood Hits	117	Target Neighborhood Hits	86	Shared Neighborhood Hits	60
SwissProt Accessions	P46467, Q91W22, Q9R1C9	Gene names	Vps4b, Skd1
Domain Architecture
Description	Vacuolar protein sorting-associating protein 4B (Protein SKD1).

FIGN_MOUSE
θ value	3.87602e-27 (rank : 42)	NC score	0.874216 (rank : 42)
Query Neighborhood Hits	117	Target Neighborhood Hits	165	Shared Neighborhood Hits	55
SwissProt Accessions	Q9ERZ6, Q3TPB0, Q3UP57, Q6PCM0	Gene names	Fign
Domain Architecture	No domain graphic available
Description	Fidgetin.

FIGN_HUMAN
θ value	1.47289e-26 (rank : 43)	NC score	0.868451 (rank : 43)
Query Neighborhood Hits	117	Target Neighborhood Hits	176	Shared Neighborhood Hits	55
SwissProt Accessions	Q5HY92, Q9H6M5, Q9NVZ9	Gene names	FIGN
Domain Architecture	No domain graphic available
Description	Fidgetin.

BCS1_MOUSE
θ value	1.2105e-12 (rank : 44)	NC score	0.710968 (rank : 45)
Query Neighborhood Hits	117	Target Neighborhood Hits	64	Shared Neighborhood Hits	50
SwissProt Accessions	Q9CZP5	Gene names	Bcs1l
Domain Architecture
Description	Mitochondrial chaperone BCS1 (BCS1-like protein).

BCS1_HUMAN
θ value	4.59992e-12 (rank : 45)	NC score	0.718335 (rank : 44)
Query Neighborhood Hits	117	Target Neighborhood Hits	61	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y276, Q7Z2V7	Gene names	BCS1L, BCS1
Domain Architecture
Description	Mitochondrial chaperone BCS1 (BCS1-like protein) (H-BCS1).

ATD3B_HUMAN
θ value	4.30538e-10 (rank : 46)	NC score	0.629192 (rank : 49)
Query Neighborhood Hits	117	Target Neighborhood Hits	340	Shared Neighborhood Hits	62
SwissProt Accessions	Q5T9A4, Q6ZRB5, Q9BUK4, Q9ULE7	Gene names	ATAD3B, KIAA1273
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3B.

ATAD3_MOUSE
θ value	2.79066e-09 (rank : 47)	NC score	0.619934 (rank : 50)
Query Neighborhood Hits	117	Target Neighborhood Hits	326	Shared Neighborhood Hits	64
SwissProt Accessions	Q925I1, Q3UE74, Q69ZM7, Q8C6C6	Gene names	Atad3, Atad3a, Kiaa1273
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3 (AAA-ATPase TOB3).

ATD3A_HUMAN
θ value	2.36244e-08 (rank : 48)	NC score	0.637878 (rank : 48)
Query Neighborhood Hits	117	Target Neighborhood Hits	248	Shared Neighborhood Hits	61
SwissProt Accessions	Q9NVI7, Q8N275, Q96A50	Gene names	ATAD3A
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3A.

TRP13_MOUSE
θ value	2.36244e-08 (rank : 49)	NC score	0.710382 (rank : 46)
Query Neighborhood Hits	117	Target Neighborhood Hits	81	Shared Neighborhood Hits	57
SwissProt Accessions	Q3UA06, Q3UQG6, Q9CWW8	Gene names	Trip13
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 13 (Thyroid hormone receptor interactor 13) (Trip-13).

TRP13_HUMAN
θ value	5.26297e-08 (rank : 50)	NC score	0.706895 (rank : 47)
Query Neighborhood Hits	117	Target Neighborhood Hits	81	Shared Neighborhood Hits	58
SwissProt Accessions	Q15645, O15324	Gene names	TRIP13
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 13 (Thyroid hormone receptor interactor 13) (Trip-13) (Human papillomavirus type 16 E1 protein- binding protein) (HPV16 E1 protein-binding protein) (16E1-BP).

CLPX_HUMAN
θ value	1.87187e-05 (rank : 51)	NC score	0.459857 (rank : 51)
Query Neighborhood Hits	117	Target Neighborhood Hits	72	Shared Neighborhood Hits	51
SwissProt Accessions	O76031, Q9H4D9	Gene names	CLPX
Domain Architecture
Description	ATP-dependent Clp protease ATP-binding subunit ClpX-like, mitochondrial precursor.

CLPX_MOUSE
θ value	1.87187e-05 (rank : 52)	NC score	0.457928 (rank : 52)
Query Neighborhood Hits	117	Target Neighborhood Hits	73	Shared Neighborhood Hits	51
SwissProt Accessions	Q9JHS4, Q9WVD1	Gene names	Clpx
Domain Architecture
Description	ATP-dependent Clp protease ATP-binding subunit ClpX-like, mitochondrial precursor.

LONM_HUMAN
θ value	0.00665767 (rank : 53)	NC score	0.440437 (rank : 53)
Query Neighborhood Hits	117	Target Neighborhood Hits	130	Shared Neighborhood Hits	58
SwissProt Accessions	P36776, P36777, Q9UQ95	Gene names	PRSS15
Domain Architecture
Description	Lon protease homolog, mitochondrial precursor (EC 3.4.21.-) (Lon protease-like protein) (LONP) (LONHs).

RENT1_MOUSE
θ value	0.0961366 (rank : 54)	NC score	0.045190 (rank : 70)
Query Neighborhood Hits	117	Target Neighborhood Hits	54	Shared Neighborhood Hits	12
SwissProt Accessions	Q9EPU0, Q99PR4	Gene names	Upf1, Rent1
Domain Architecture
Description	Regulator of nonsense transcripts 1 (EC 3.6.1.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up- frameshift suppressor 1 homolog) (mUpf1).

GOGA4_HUMAN
θ value	0.125558 (rank : 55)	NC score	0.011075 (rank : 107)
Query Neighborhood Hits	117	Target Neighborhood Hits	2034	Shared Neighborhood Hits	51
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

RENT1_HUMAN
θ value	0.125558 (rank : 56)	NC score	0.043742 (rank : 71)
Query Neighborhood Hits	117	Target Neighborhood Hits	51	Shared Neighborhood Hits	12
SwissProt Accessions	Q92900, O00239, O43343, Q86Z25, Q92842	Gene names	UPF1, KIAA0221, RENT1
Domain Architecture
Description	Regulator of nonsense transcripts 1 (EC 3.6.1.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up- frameshift suppressor 1 homolog) (hUpf1).

RUVB1_HUMAN
θ value	0.125558 (rank : 57)	NC score	0.318985 (rank : 54)
Query Neighborhood Hits	117	Target Neighborhood Hits	78	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Y265, Q9BSX9	Gene names	RUVBL1, NMP238, TIP49, TIP49A
Domain Architecture
Description	RuvB-like 1 (EC 3.6.1.-) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (TIP49a) (Pontin 52) (Nuclear matrix protein 238) (NMP 238) (54 kDa erythrocyte cytosolic protein) (ECP-54) (TIP60-associated protein 54-alpha) (TAP54-alpha).

RUVB1_MOUSE
θ value	0.125558 (rank : 58)	NC score	0.318947 (rank : 55)
Query Neighborhood Hits	117	Target Neighborhood Hits	78	Shared Neighborhood Hits	57
SwissProt Accessions	P60122, O35753	Gene names	Ruvbl1, Tip49, Tip49a
Domain Architecture
Description	RuvB-like 1 (EC 3.6.1.-) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (TIP49a) (Pontin 52) (DNA helicase p50).

RFC1_MOUSE
θ value	0.163984 (rank : 59)	NC score	0.130389 (rank : 58)
Query Neighborhood Hits	117	Target Neighborhood Hits	290	Shared Neighborhood Hits	49
SwissProt Accessions	P35601	Gene names	Rfc1, Ibf-1, Recc1
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (A1-P145) (Differentiation- specific element-binding protein) (ISRE-binding protein).

K2C4_HUMAN
θ value	0.21417 (rank : 60)	NC score	0.031551 (rank : 73)
Query Neighborhood Hits	117	Target Neighborhood Hits	471	Shared Neighborhood Hits	39
SwissProt Accessions	P19013, Q6GTR8, Q96LA7, Q9BTL1	Gene names	KRT4, CYK4
Domain Architecture
Description	Keratin, type II cytoskeletal 4 (Cytokeratin-4) (CK-4) (Keratin-4) (K4).

PCNT_HUMAN
θ value	0.365318 (rank : 61)	NC score	0.013726 (rank : 103)
Query Neighborhood Hits	117	Target Neighborhood Hits	1551	Shared Neighborhood Hits	46
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

RFC1_HUMAN
θ value	0.62314 (rank : 62)	NC score	0.115106 (rank : 63)
Query Neighborhood Hits	117	Target Neighborhood Hits	352	Shared Neighborhood Hits	45
SwissProt Accessions	P35251, Q5XKF5, Q6PKU0, Q86V41, Q86V46	Gene names	RFC1, RFC140
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (DNA-binding protein PO-GA).

TBCD4_HUMAN
θ value	0.813845 (rank : 63)	NC score	0.013662 (rank : 104)
Query Neighborhood Hits	117	Target Neighborhood Hits	357	Shared Neighborhood Hits	13
SwissProt Accessions	O60343, Q5W0B9	Gene names	TBC1D4, KIAA0603
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160).

CING_HUMAN
θ value	1.06291 (rank : 64)	NC score	0.009311 (rank : 109)
Query Neighborhood Hits	117	Target Neighborhood Hits	1275	Shared Neighborhood Hits	44
SwissProt Accessions	Q9P2M7, Q5T386, Q9NR25	Gene names	CGN, KIAA1319
Domain Architecture
Description	Cingulin.

K2C8_MOUSE
θ value	1.06291 (rank : 65)	NC score	0.027670 (rank : 97)
Query Neighborhood Hits	117	Target Neighborhood Hits	576	Shared Neighborhood Hits	40
SwissProt Accessions	P11679, Q3KQK5, Q3TGI1, Q3TJE1, Q3TKY7, Q61463, Q61518, Q61519	Gene names	Krt8, Krt2-8
Domain Architecture
Description	Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Cytokeratin endo A).

WRIP1_MOUSE
θ value	1.06291 (rank : 66)	NC score	0.235981 (rank : 56)
Query Neighborhood Hits	117	Target Neighborhood Hits	93	Shared Neighborhood Hits	49
SwissProt Accessions	Q91XU0, Q3TCT7, Q6PDF0, Q8BUW5, Q8BWP6, Q8BY55, Q921W3, Q9EQL3	Gene names	Wrnip1, Whip
Domain Architecture	No domain graphic available
Description	ATPase WRNIP1 (Werner helicase-interacting protein 1).

K22E_HUMAN
θ value	1.38821 (rank : 67)	NC score	0.028855 (rank : 83)
Query Neighborhood Hits	117	Target Neighborhood Hits	515	Shared Neighborhood Hits	38
SwissProt Accessions	P35908	Gene names	KRT2A, KRT2E
Domain Architecture
Description	Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (K2e) (CK 2e).

K2C1_HUMAN
θ value	1.38821 (rank : 68)	NC score	0.027957 (rank : 94)
Query Neighborhood Hits	117	Target Neighborhood Hits	624	Shared Neighborhood Hits	40
SwissProt Accessions	P04264, Q14720, Q6GSJ0, Q9H298	Gene names	KRT1, KRTA
Domain Architecture
Description	Keratin, type II cytoskeletal 1 (Cytokeratin-1) (CK-1) (Keratin-1) (K1) (67 kDa cytokeratin) (Hair alpha protein).

K2C4_MOUSE
θ value	1.38821 (rank : 69)	NC score	0.028371 (rank : 91)
Query Neighborhood Hits	117	Target Neighborhood Hits	521	Shared Neighborhood Hits	39
SwissProt Accessions	P07744, Q6P3F5	Gene names	Krt4, Krt2-4
Domain Architecture
Description	Keratin, type II cytoskeletal 4 (Cytokeratin-4) (CK-4) (Keratin-4) (K4) (Cytoskeletal 57 kDa keratin).

KRHB1_HUMAN
θ value	1.38821 (rank : 70)	NC score	0.029038 (rank : 80)
Query Neighborhood Hits	117	Target Neighborhood Hits	461	Shared Neighborhood Hits	35
SwissProt Accessions	Q14533, Q14846, Q16274, Q8WU52, Q9BR74	Gene names	KRTHB1, MLN137
Domain Architecture
Description	Keratin, type II cuticular Hb1 (Hair keratin, type II Hb1) (ghHKb1) (ghHb1) (MLN 137).

KRHB3_HUMAN
θ value	1.38821 (rank : 71)	NC score	0.029173 (rank : 79)
Query Neighborhood Hits	117	Target Neighborhood Hits	438	Shared Neighborhood Hits	34
SwissProt Accessions	P78385, Q9NSB3	Gene names	KRTHB3
Domain Architecture
Description	Keratin, type II cuticular Hb3 (Hair keratin, type II Hb3).

KRHB6_HUMAN
θ value	1.38821 (rank : 72)	NC score	0.029026 (rank : 81)
Query Neighborhood Hits	117	Target Neighborhood Hits	447	Shared Neighborhood Hits	35
SwissProt Accessions	O43790, P78387	Gene names	KRTHB6
Domain Architecture
Description	Keratin, type II cuticular Hb6 (Hair keratin, type II Hb6) (ghHb6).

M10L1_MOUSE
θ value	1.38821 (rank : 73)	NC score	0.024025 (rank : 100)
Query Neighborhood Hits	117	Target Neighborhood Hits	59	Shared Neighborhood Hits	7
SwissProt Accessions	Q99MV5, Q7TPA9, Q8C3W0, Q924C2	Gene names	Mov10l1, Champ
Domain Architecture
Description	Putative helicase Mov10l1 (EC 3.6.1.-) (Moloney leukemia virus 10-like protein 1) (MOV10-like 1) (Cardiac helicase activated by MEF2 protein) (Cardiac-specific RNA helicase).

MDN1_HUMAN
θ value	1.38821 (rank : 74)	NC score	0.043216 (rank : 72)
Query Neighborhood Hits	117	Target Neighborhood Hits	662	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

RUVB2_HUMAN
θ value	1.38821 (rank : 75)	NC score	0.126406 (rank : 59)
Query Neighborhood Hits	117	Target Neighborhood Hits	43	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y230, Q6PK27, Q9Y361	Gene names	RUVBL2, TIP48, TIP49B
Domain Architecture
Description	RuvB-like 2 (EC 3.6.1.-) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (TIP49b) (Repressing pontin 52) (Reptin 52) (51 kDa erythrocyte cytosolic protein) (ECP-51) (TIP60-associated protein 54-beta) (TAP54-beta).

RUVB2_MOUSE
θ value	1.38821 (rank : 76)	NC score	0.123826 (rank : 60)
Query Neighborhood Hits	117	Target Neighborhood Hits	42	Shared Neighborhood Hits	38
SwissProt Accessions	Q9WTM5	Gene names	Ruvbl2
Domain Architecture
Description	RuvB-like 2 (EC 3.6.1.-) (p47 protein).

THNSL_HUMAN
θ value	1.38821 (rank : 77)	NC score	0.115815 (rank : 62)
Query Neighborhood Hits	117	Target Neighborhood Hits	47	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IYQ7, Q5VV21	Gene names	THNSL1
Domain Architecture	No domain graphic available
Description	Threonine synthase-like 1.

THNSL_MOUSE
θ value	1.38821 (rank : 78)	NC score	0.118146 (rank : 61)
Query Neighborhood Hits	117	Target Neighborhood Hits	47	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BH55	Gene names	Thnsl1
Domain Architecture	No domain graphic available
Description	Threonine synthase-like 1.

K2C1_MOUSE
θ value	1.81305 (rank : 79)	NC score	0.029889 (rank : 76)
Query Neighborhood Hits	117	Target Neighborhood Hits	477	Shared Neighborhood Hits	40
SwissProt Accessions	P04104	Gene names	Krt1, Krt2-1
Domain Architecture
Description	Keratin, type II cytoskeletal 1 (Cytokeratin-1) (CK-1) (Keratin-1) (K1) (67 kDa cytokeratin).

TXLNG_MOUSE
θ value	1.81305 (rank : 80)	NC score	0.018432 (rank : 101)
Query Neighborhood Hits	117	Target Neighborhood Hits	552	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BHN1, Q8BP11	Gene names	Txlng
Domain Architecture	No domain graphic available
Description	Gamma-taxilin.

WRIP1_HUMAN
θ value	1.81305 (rank : 81)	NC score	0.232252 (rank : 57)
Query Neighborhood Hits	117	Target Neighborhood Hits	100	Shared Neighborhood Hits	48
SwissProt Accessions	Q96S55, Q53EP6, Q59ET8, Q5W0E2, Q5W0E4, Q8WV26, Q9H681, Q9NRJ6	Gene names	WRNIP1, WHIP
Domain Architecture	No domain graphic available
Description	ATPase WRNIP1 (Werner helicase-interacting protein 1).

IMA7_MOUSE
θ value	2.36792 (rank : 82)	NC score	0.008086 (rank : 111)
Query Neighborhood Hits	117	Target Neighborhood Hits	50	Shared Neighborhood Hits	4
SwissProt Accessions	O35345, Q9CVP9	Gene names	Kpna6, Kpna5
Domain Architecture
Description	Importin alpha-7 subunit (Karyopherin alpha-6 subunit) (Importin alpha S2).

K2C1B_MOUSE
θ value	2.36792 (rank : 83)	NC score	0.028934 (rank : 82)
Query Neighborhood Hits	117	Target Neighborhood Hits	503	Shared Neighborhood Hits	39
SwissProt Accessions	Q6IFZ6	Gene names	Krt1b
Domain Architecture	No domain graphic available
Description	Keratin, type II cytoskeletal 1b (Type II keratin Kb39) (Embryonic type II keratin-1).

KRHB4_HUMAN
θ value	2.36792 (rank : 84)	NC score	0.029890 (rank : 75)
Query Neighborhood Hits	117	Target Neighborhood Hits	352	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NSB2	Gene names	KRTHB4
Domain Architecture
Description	Keratin, type II cuticular Hb4 (Hair keratin, type II Hb4).

KRHB5_HUMAN
θ value	2.36792 (rank : 85)	NC score	0.029305 (rank : 77)
Query Neighborhood Hits	117	Target Neighborhood Hits	321	Shared Neighborhood Hits	33
SwissProt Accessions	P78386, Q9NSB1	Gene names	KRTHB5
Domain Architecture
Description	Keratin, type II cuticular Hb5 (Hair keratin, type II Hb5).

K2C6A_MOUSE
θ value	3.0926 (rank : 86)	NC score	0.028724 (rank : 84)
Query Neighborhood Hits	117	Target Neighborhood Hits	481	Shared Neighborhood Hits	39
SwissProt Accessions	P50446, Q9Z332	Gene names	Krt6a, Ker2, Krt2-6, Krt2-6a, Krt6
Domain Architecture
Description	Keratin, type II cytoskeletal 6A (Cytokeratin-6A) (CK 6A) (K6a keratin) (Keratin-6 alpha) (mK6-alpha).

K2C6B_MOUSE
θ value	3.0926 (rank : 87)	NC score	0.028627 (rank : 86)
Query Neighborhood Hits	117	Target Neighborhood Hits	506	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z331	Gene names	Krt6b, K6-beta, Krt2-6b
Domain Architecture	No domain graphic available
Description	Keratin, type II cytoskeletal 6B (Cytokeratin-6B) (CK 6B) (K6b keratin) (Keratin-6 beta) (mK6-beta).

PIBF1_HUMAN
θ value	3.0926 (rank : 88)	NC score	0.008013 (rank : 112)
Query Neighborhood Hits	117	Target Neighborhood Hits	1041	Shared Neighborhood Hits	34
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

TPR_HUMAN
θ value	3.0926 (rank : 89)	NC score	0.011068 (rank : 108)
Query Neighborhood Hits	117	Target Neighborhood Hits	1921	Shared Neighborhood Hits	49
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

CEP63_HUMAN
θ value	4.03905 (rank : 90)	NC score	0.006705 (rank : 118)
Query Neighborhood Hits	117	Target Neighborhood Hits	1005	Shared Neighborhood Hits	32
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

CR034_HUMAN
θ value	4.03905 (rank : 91)	NC score	0.011148 (rank : 106)
Query Neighborhood Hits	117	Target Neighborhood Hits	538	Shared Neighborhood Hits	35
SwissProt Accessions	Q5BJE1, Q6ZP67, Q6ZU20	Gene names	C18orf34
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34.

K2C6A_HUMAN
θ value	4.03905 (rank : 92)	NC score	0.028598 (rank : 87)
Query Neighborhood Hits	117	Target Neighborhood Hits	505	Shared Neighborhood Hits	41
SwissProt Accessions	P02538, Q6NT67, Q96CL4	Gene names	KRT6A, K6A
Domain Architecture
Description	Keratin, type II cytoskeletal 6A (Cytokeratin-6A) (CK 6A) (K6a keratin).

K2C6B_HUMAN
θ value	4.03905 (rank : 93)	NC score	0.028558 (rank : 88)
Query Neighborhood Hits	117	Target Neighborhood Hits	526	Shared Neighborhood Hits	40
SwissProt Accessions	P04259, P48669	Gene names	KRT6B, K6B
Domain Architecture
Description	Keratin, type II cytoskeletal 6B (Cytokeratin-6B) (CK 6B) (K6b keratin).

K2C6C_HUMAN
θ value	4.03905 (rank : 94)	NC score	0.028538 (rank : 89)
Query Neighborhood Hits	117	Target Neighborhood Hits	503	Shared Neighborhood Hits	41
SwissProt Accessions	P48666	Gene names	KRT6C
Domain Architecture
Description	Keratin, type II cytoskeletal 6C (Cytokeratin-6C) (CK 6C) (K6c keratin).

K2C6E_HUMAN
θ value	4.03905 (rank : 95)	NC score	0.028509 (rank : 90)
Query Neighborhood Hits	117	Target Neighborhood Hits	516	Shared Neighborhood Hits	40
SwissProt Accessions	P48668, Q7RTN9	Gene names	KRT6E
Domain Architecture
Description	Keratin, type II cytoskeletal 6E (Cytokeratin-6E) (CK 6E) (K6e keratin) (Keratin K6h).

K2C8_HUMAN
θ value	4.03905 (rank : 96)	NC score	0.026566 (rank : 98)
Query Neighborhood Hits	117	Target Neighborhood Hits	593	Shared Neighborhood Hits	40
SwissProt Accessions	P05787, Q14099, Q14716, Q14717, Q53GJ0, Q6DHW5, Q6GMY0, Q96J60	Gene names	KRT8, CYK8
Domain Architecture
Description	Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8).

TXLNG_HUMAN
θ value	4.03905 (rank : 97)	NC score	0.016718 (rank : 102)
Query Neighborhood Hits	117	Target Neighborhood Hits	568	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NUQ3, Q9P0X1	Gene names	TXLNG, CXorf15, LSR5
Domain Architecture	No domain graphic available
Description	Gamma-taxilin (Lipopolysaccharide-specific response protein 5).

HOOK3_MOUSE
θ value	5.27518 (rank : 98)	NC score	0.006919 (rank : 115)
Query Neighborhood Hits	117	Target Neighborhood Hits	1007	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BUK6, Q8BV48, Q8BW57, Q8BY41	Gene names	Hook3
Domain Architecture
Description	Hook homolog 3.

K22O_HUMAN
θ value	5.27518 (rank : 99)	NC score	0.028121 (rank : 93)
Query Neighborhood Hits	117	Target Neighborhood Hits	485	Shared Neighborhood Hits	39
SwissProt Accessions	Q01546, Q7Z795	Gene names	KRT76, KRT2B, KRT2P
Domain Architecture
Description	Keratin, type II cytoskeletal 2 oral (Cytokeratin-2P) (K2P) (CK 2P) (Keratin 76).

K2C5_HUMAN
θ value	5.27518 (rank : 100)	NC score	0.027853 (rank : 96)
Query Neighborhood Hits	117	Target Neighborhood Hits	506	Shared Neighborhood Hits	40
SwissProt Accessions	P13647, Q6PI71, Q6UBJ0, Q8TA91	Gene names	KRT5
Domain Architecture
Description	Keratin, type II cytoskeletal 5 (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (58 kDa cytokeratin).

K2C5_MOUSE
θ value	5.27518 (rank : 101)	NC score	0.027945 (rank : 95)
Query Neighborhood Hits	117	Target Neighborhood Hits	505	Shared Neighborhood Hits	40
SwissProt Accessions	Q922U2, Q920F2	Gene names	Krt5, Krt2-5
Domain Architecture	No domain graphic available
Description	Keratin, type II cytoskeletal 5 (Cytokeratin-5) (CK-5) (Keratin-5) (K5).

KRHB5_MOUSE
θ value	5.27518 (rank : 102)	NC score	0.029287 (rank : 78)
Query Neighborhood Hits	117	Target Neighborhood Hits	294	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Z2T6, Q8CE83, Q9D7M4	Gene names	Krthb5, Krt2-18
Domain Architecture
Description	Keratin, type II cuticular Hb5 (Hair keratin, type II Hb5).

KRHB6_MOUSE
θ value	5.27518 (rank : 103)	NC score	0.028652 (rank : 85)
Query Neighborhood Hits	117	Target Neighborhood Hits	413	Shared Neighborhood Hits	36
SwissProt Accessions	P97861, Q3TTV9	Gene names	Krthb6, Krt2-10
Domain Architecture	No domain graphic available
Description	Keratin, type II cuticular Hb6 (Hair keratin, type II Hb6).

MOV10_HUMAN
θ value	5.27518 (rank : 104)	NC score	0.030479 (rank : 74)
Query Neighborhood Hits	117	Target Neighborhood Hits	46	Shared Neighborhood Hits	15
SwissProt Accessions	Q9HCE1, Q8TEF0, Q9BSY3, Q9BUJ9	Gene names	MOV10, KIAA1631
Domain Architecture
Description	Putative helicase MOV-10 (EC 3.6.1.-) (Moloney leukemia virus 10 protein).

MOV10_MOUSE
θ value	5.27518 (rank : 105)	NC score	0.025986 (rank : 99)
Query Neighborhood Hits	117	Target Neighborhood Hits	39	Shared Neighborhood Hits	12
SwissProt Accessions	P23249, Q9DC64	Gene names	Mov10, Gb110
Domain Architecture
Description	Putative helicase MOV-10 (EC 3.6.1.-) (Moloney leukemia virus 10 protein).

BICD1_MOUSE
θ value	6.88961 (rank : 106)	NC score	0.006903 (rank : 116)
Query Neighborhood Hits	117	Target Neighborhood Hits	837	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BR07, O55206, Q8BQ18, Q8BRR8, Q8C4D3, Q8CAK6, Q8R2J4, Q8R2J5, Q8R2J6, Q91YP7	Gene names	Bicd1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

MYH1_HUMAN
θ value	6.88961 (rank : 107)	NC score	0.005187 (rank : 121)
Query Neighborhood Hits	117	Target Neighborhood Hits	1478	Shared Neighborhood Hits	47
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

RGPD8_HUMAN
θ value	6.88961 (rank : 108)	NC score	0.005719 (rank : 119)
Query Neighborhood Hits	117	Target Neighborhood Hits	135	Shared Neighborhood Hits	5
SwissProt Accessions	Q99666	Gene names	RGPD8, RANBP2L1
Domain Architecture	No domain graphic available
Description	RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 1) (RanBP2L1) (Sperm membrane protein BS-63).

RT15_MOUSE
θ value	6.88961 (rank : 109)	NC score	0.013125 (rank : 105)
Query Neighborhood Hits	117	Target Neighborhood Hits	50	Shared Neighborhood Hits	6
SwissProt Accessions	Q9DC71, Q7TMG9, Q8C7F1, Q9CVE0, Q9CWX1	Gene names	Mrps15, Rpms15
Domain Architecture
Description	28S ribosomal protein S15, mitochondrial precursor (S15mt) (MRP-S15).

COG3_HUMAN
θ value	8.99809 (rank : 110)	NC score	0.007143 (rank : 114)
Query Neighborhood Hits	117	Target Neighborhood Hits	56	Shared Neighborhood Hits	5
SwissProt Accessions	Q96JB2, Q5VT70, Q8IXX4, Q9BZ92	Gene names	COG3, SEC34
Domain Architecture
Description	Conserved oligomeric Golgi complex component 3 (Vesicle docking protein SEC34 homolog) (p94).

GCP6_HUMAN
θ value	8.99809 (rank : 111)	NC score	0.006850 (rank : 117)
Query Neighborhood Hits	117	Target Neighborhood Hits	295	Shared Neighborhood Hits	8
SwissProt Accessions	Q96RT7, Q5JZ80, Q6PJ40, Q86YE9, Q9BY91, Q9UGX3, Q9UGX4	Gene names	TUBGCP6, GCP6, KIAA1669
Domain Architecture
Description	Gamma-tubulin complex component 6 (GCP-6).

IQGA3_HUMAN
θ value	8.99809 (rank : 112)	NC score	0.004419 (rank : 123)
Query Neighborhood Hits	117	Target Neighborhood Hits	125	Shared Neighborhood Hits	6
SwissProt Accessions	Q86VI3	Gene names	IQGAP3
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP3.

KRHB4_MOUSE
θ value	8.99809 (rank : 113)	NC score	0.028131 (rank : 92)
Query Neighborhood Hits	117	Target Neighborhood Hits	344	Shared Neighborhood Hits	36
SwissProt Accessions	Q99M73	Gene names	Krthb4, Krt2-16
Domain Architecture
Description	Keratin, type II cuticular Hb4 (Hair keratin, type II Hb4) (65 kDa type II keratin).

MYH9_MOUSE
θ value	8.99809 (rank : 114)	NC score	0.005124 (rank : 122)
Query Neighborhood Hits	117	Target Neighborhood Hits	1829	Shared Neighborhood Hits	53
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

NALP5_MOUSE
θ value	8.99809 (rank : 115)	NC score	0.005543 (rank : 120)
Query Neighborhood Hits	117	Target Neighborhood Hits	560	Shared Neighborhood Hits	15
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

NUP88_MOUSE
θ value	8.99809 (rank : 116)	NC score	0.007442 (rank : 113)
Query Neighborhood Hits	117	Target Neighborhood Hits	239	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CEC0, Q80Z13, Q8K090	Gene names	Nup88
Domain Architecture	No domain graphic available
Description	Nuclear pore complex protein Nup88 (Nucleoporin Nup88) (88 kDa nuclear pore complex protein).

RBP22_HUMAN
θ value	8.99809 (rank : 117)	NC score	0.008428 (rank : 110)
Query Neighborhood Hits	117	Target Neighborhood Hits	165	Shared Neighborhood Hits	8
SwissProt Accessions	Q53T03, Q53QN2, Q59GM7	Gene names	RANBP2L2
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 2 (RanBP2L2).

KAD6_HUMAN
θ value	θ > 10 (rank : 118)	NC score	0.090955 (rank : 65)
Query Neighborhood Hits	117	Target Neighborhood Hits	46	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y3D8	Gene names	AK6
Domain Architecture
Description	Adenylate kinase isoenzyme 6 (EC 2.7.4.3) (ATP-AMP transphosphorylase 6).

KAD6_MOUSE
θ value	θ > 10 (rank : 119)	NC score	0.069932 (rank : 67)
Query Neighborhood Hits	117	Target Neighborhood Hits	34	Shared Neighborhood Hits	21
SwissProt Accessions	Q8VCP8	Gene names	Ak6
Domain Architecture	No domain graphic available
Description	Adenylate kinase isoenzyme 6 (EC 2.7.4.3) (ATP-AMP transphosphorylase 6).

RFC4_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.095602 (rank : 64)
Query Neighborhood Hits	117	Target Neighborhood Hits	64	Shared Neighborhood Hits	41
SwissProt Accessions	P35249, Q6FHX7	Gene names	RFC4
Domain Architecture
Description	Replication factor C subunit 4 (Replication factor C 37 kDa subunit) (RF-C 37 kDa subunit) (RFC37) (Activator 1 37 kDa subunit) (A1 37 kDa subunit).

RFC4_MOUSE
θ value	θ > 10 (rank : 121)	NC score	0.084139 (rank : 66)
Query Neighborhood Hits	117	Target Neighborhood Hits	65	Shared Neighborhood Hits	41
SwissProt Accessions	Q99J62	Gene names	Rfc4
Domain Architecture	No domain graphic available
Description	Replication factor C subunit 4.

RFC5_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.064481 (rank : 69)
Query Neighborhood Hits	117	Target Neighborhood Hits	60	Shared Neighborhood Hits	31
SwissProt Accessions	P40937	Gene names	RFC5
Domain Architecture
Description	Replication factor C subunit 5 (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36) (Activator 1 36 kDa subunit) (A1 36 kDa subunit).

RFC5_MOUSE
θ value	θ > 10 (rank : 123)	NC score	0.065920 (rank : 68)
Query Neighborhood Hits	117	Target Neighborhood Hits	58	Shared Neighborhood Hits	33
SwissProt Accessions	Q9D0F6	Gene names	Rfc5
Domain Architecture
Description	Replication factor C subunit 5 (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36) (Activator 1 36 kDa subunit) (A1 36 kDa subunit).

Hits sorted by NC score

PRS8_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	117	Target Neighborhood Hits	117	Shared Neighborhood Hits	117
SwissProt Accessions	P62195, O35051, O43208, P47210, P52915, P52916	Gene names	PSMC5, SUG1
Domain Architecture
Description	26S protease regulatory subunit 8 (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (p45/SUG) (Thyroid hormone receptor- interacting protein 1) (TRIP1).

PRS8_MOUSE
NC score	0.999962 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	117	Target Neighborhood Hits	117	Shared Neighborhood Hits	117
SwissProt Accessions	P62196, O35051, P47210, P52915, P52916, Q3UL51, Q9CWN5	Gene names	Psmc5, Sug1
Domain Architecture
Description	26S protease regulatory subunit 8 (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (p45/SUG) (mSUG1).

PRS4_HUMAN
NC score	0.989284 (rank : 3)	θ value	3.32542e-95 (rank : 3)
Query Neighborhood Hits	117	Target Neighborhood Hits	84	Shared Neighborhood Hits	66
SwissProt Accessions	P62191, P49014, Q03527, Q6IAW0, Q96AZ3	Gene names	PSMC1
Domain Architecture
Description	26S protease regulatory subunit 4 (P26s4) (Proteasome 26S subunit ATPase 1).

PRS4_MOUSE
NC score	0.989284 (rank : 4)	θ value	3.32542e-95 (rank : 4)
Query Neighborhood Hits	117	Target Neighborhood Hits	84	Shared Neighborhood Hits	66
SwissProt Accessions	P62192, P49014, Q03527, Q96AZ3	Gene names	Psmc1
Domain Architecture
Description	26S protease regulatory subunit 4 (P26s4) (Proteasome 26S subunit ATPase 1).

PRS10_HUMAN
NC score	0.988802 (rank : 5)	θ value	1.30768e-91 (rank : 5)
Query Neighborhood Hits	117	Target Neighborhood Hits	95	Shared Neighborhood Hits	66
SwissProt Accessions	P62333, P49719, Q6IBU3, Q92524	Gene names	PSMC6, SUG2
Domain Architecture
Description	26S protease regulatory subunit S10B (Proteasome subunit p42) (Proteasome 26S subunit ATPase 6).

PRS10_MOUSE
NC score	0.988802 (rank : 6)	θ value	1.30768e-91 (rank : 6)
Query Neighborhood Hits	117	Target Neighborhood Hits	95	Shared Neighborhood Hits	66
SwissProt Accessions	P62334, P49719, Q3TKK1, Q810A6, Q92524, Q9CXH9	Gene names	Psmc6, Sug2
Domain Architecture
Description	26S protease regulatory subunit S10B (Proteasome subunit p42) (Proteasome 26S subunit ATPase 6).

PRS7_HUMAN
NC score	0.988194 (rank : 7)	θ value	1.70789e-91 (rank : 7)
Query Neighborhood Hits	117	Target Neighborhood Hits	66	Shared Neighborhood Hits	62
SwissProt Accessions	P35998	Gene names	PSMC2, MSS1
Domain Architecture
Description	26S protease regulatory subunit 7 (Proteasome 26S subunit ATPase 2) (Protein MSS1).

PRS7_MOUSE
NC score	0.988182 (rank : 8)	θ value	1.70789e-91 (rank : 8)
Query Neighborhood Hits	117	Target Neighborhood Hits	67	Shared Neighborhood Hits	62
SwissProt Accessions	P46471, O08531, Q3TGX5, Q9DBA1	Gene names	Psmc2, Mss1
Domain Architecture
Description	26S protease regulatory subunit 7 (Proteasome 26S subunit ATPase 2) (Protein MSS1).

PRS6A_MOUSE
NC score	0.985299 (rank : 9)	θ value	1.40038e-85 (rank : 10)
Query Neighborhood Hits	117	Target Neighborhood Hits	85	Shared Neighborhood Hits	61
SwissProt Accessions	O88685	Gene names	Psmc3, Tbp1
Domain Architecture
Description	26S protease regulatory subunit 6A (Proteasome 26S subunit ATPase 3) (TAT-binding protein 1) (TBP-1).

PRS6A_HUMAN
NC score	0.985212 (rank : 10)	θ value	2.16048e-86 (rank : 9)
Query Neighborhood Hits	117	Target Neighborhood Hits	87	Shared Neighborhood Hits	61
SwissProt Accessions	P17980, Q96HD3	Gene names	PSMC3, TBP1
Domain Architecture
Description	26S protease regulatory subunit 6A (Proteasome 26S subunit ATPase 3) (TAT-binding protein 1) (TBP-1) (Proteasome subunit P50).

PRS6B_HUMAN
NC score	0.983677 (rank : 11)	θ value	5.50685e-82 (rank : 11)
Query Neighborhood Hits	117	Target Neighborhood Hits	85	Shared Neighborhood Hits	57
SwissProt Accessions	P43686, Q96FV5, Q9UBM3, Q9UEX3	Gene names	PSMC4, TBP7
Domain Architecture
Description	26S protease regulatory subunit 6B (Proteasome 26S subunit ATPase 4) (MIP224) (MB67-interacting protein) (TAT-binding protein 7) (TBP-7).

PRS6B_MOUSE
NC score	0.983187 (rank : 12)	θ value	3.94648e-80 (rank : 12)
Query Neighborhood Hits	117	Target Neighborhood Hits	89	Shared Neighborhood Hits	57
SwissProt Accessions	P54775	Gene names	Psmc4, Tbp7
Domain Architecture
Description	26S protease regulatory subunit 6B (Proteasome 26S subunit ATPase 4) (MIP224) (MB67-interacting protein) (TAT-binding protein 7) (TBP-7) (CIP21).

TERA_HUMAN
NC score	0.952650 (rank : 13)	θ value	6.56568e-51 (rank : 16)
Query Neighborhood Hits	117	Target Neighborhood Hits	76	Shared Neighborhood Hits	64
SwissProt Accessions	P55072, Q969G7	Gene names	VCP
Domain Architecture
Description	Transitional endoplasmic reticulum ATPase (TER ATPase) (15S Mg(2+)- ATPase p97 subunit) (Valosin-containing protein) (VCP).

TERA_MOUSE
NC score	0.952621 (rank : 14)	θ value	6.56568e-51 (rank : 17)
Query Neighborhood Hits	117	Target Neighborhood Hits	76	Shared Neighborhood Hits	64
SwissProt Accessions	Q01853	Gene names	Vcp
Domain Architecture
Description	Transitional endoplasmic reticulum ATPase (TER ATPase) (15S Mg(2+)- ATPase p97 subunit) (Valosin-containing protein) (VCP).

AFG31_MOUSE
NC score	0.951936 (rank : 15)	θ value	1.41344e-53 (rank : 15)
Query Neighborhood Hits	117	Target Neighborhood Hits	74	Shared Neighborhood Hits	61
SwissProt Accessions	Q920A7	Gene names	Afg3l1
Domain Architecture
Description	AFG3-like protein 1 (EC 3.4.24.-).

SPG7_HUMAN
NC score	0.950531 (rank : 16)	θ value	3.37202e-47 (rank : 18)
Query Neighborhood Hits	117	Target Neighborhood Hits	71	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UQ90, O75756, Q96IB0	Gene names	SPG7, CAR, CMAR, PGN
Domain Architecture
Description	Paraplegin (EC 3.4.24.-) (Spastic paraplegia protein 7).

PEX1_HUMAN
NC score	0.949876 (rank : 17)	θ value	2.04573e-44 (rank : 23)
Query Neighborhood Hits	117	Target Neighborhood Hits	98	Shared Neighborhood Hits	62
SwissProt Accessions	O43933, Q96S71, Q96S72, Q96S73, Q99994	Gene names	PEX1
Domain Architecture
Description	Peroxisome biogenesis factor 1 (Peroxin-1) (Peroxisome biogenesis disorder protein 1).

AFG32_HUMAN
NC score	0.948406 (rank : 18)	θ value	4.39379e-55 (rank : 13)
Query Neighborhood Hits	117	Target Neighborhood Hits	72	Shared Neighborhood Hits	61
SwissProt Accessions	Q9Y4W6	Gene names	AFG3L2
Domain Architecture
Description	AFG3-like protein 2 (EC 3.4.24.-) (Paraplegin-like protein).

AFG32_MOUSE
NC score	0.948189 (rank : 19)	θ value	7.49467e-55 (rank : 14)
Query Neighborhood Hits	117	Target Neighborhood Hits	73	Shared Neighborhood Hits	61
SwissProt Accessions	Q8JZQ2	Gene names	Afg3l2
Domain Architecture	No domain graphic available
Description	AFG3-like protein 2 (EC 3.4.24.-).

YMEL1_MOUSE
NC score	0.943618 (rank : 20)	θ value	3.72821e-46 (rank : 20)
Query Neighborhood Hits	117	Target Neighborhood Hits	76	Shared Neighborhood Hits	58
SwissProt Accessions	O88967, Q7TNN5	Gene names	Yme1l1
Domain Architecture
Description	ATP-dependent metalloprotease YME1L1 (EC 3.4.24.-) (YME1-like protein 1) (ATP-dependent metalloprotease FtsH1).

ATAD1_HUMAN
NC score	0.940978 (rank : 21)	θ value	1.46948e-34 (rank : 36)
Query Neighborhood Hits	117	Target Neighborhood Hits	75	Shared Neighborhood Hits	62
SwissProt Accessions	Q8NBU5, Q6P4B9, Q8N3G1, Q8WYR9, Q969Y3	Gene names	ATAD1
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 1.

ATAD1_MOUSE
NC score	0.940978 (rank : 22)	θ value	1.46948e-34 (rank : 37)
Query Neighborhood Hits	117	Target Neighborhood Hits	75	Shared Neighborhood Hits	62
SwissProt Accessions	Q9D5T0, Q3U8V2, Q9D7A4	Gene names	Atad1
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 1.

NVL_MOUSE
NC score	0.940233 (rank : 23)	θ value	1.05066e-40 (rank : 30)
Query Neighborhood Hits	117	Target Neighborhood Hits	110	Shared Neighborhood Hits	66
SwissProt Accessions	Q9DBY8, Q3USC4, Q8BW27, Q8K2B5	Gene names	Nvl
Domain Architecture
Description	Nuclear valosin-containing protein-like (Nuclear VCP-like protein) (NVLp).

YMEL1_HUMAN
NC score	0.940047 (rank : 24)	θ value	6.35935e-46 (rank : 21)
Query Neighborhood Hits	117	Target Neighborhood Hits	73	Shared Neighborhood Hits	58
SwissProt Accessions	Q96TA2, Q9H1Q0, Q9UMR9	Gene names	YME1L1, FTSH1, YME1L
Domain Architecture
Description	ATP-dependent metalloprotease YME1L1 (EC 3.4.24.-) (YME1-like protein 1) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin- associated metalloprotease) (PAMP).

NVL_HUMAN
NC score	0.939766 (rank : 25)	θ value	3.61106e-41 (rank : 29)
Query Neighborhood Hits	117	Target Neighborhood Hits	112	Shared Neighborhood Hits	67
SwissProt Accessions	O15381, Q96EM7	Gene names	NVL
Domain Architecture
Description	Nuclear valosin-containing protein-like (Nuclear VCP-like protein) (NVLp).

PEX6_HUMAN
NC score	0.938358 (rank : 26)	θ value	2.18568e-46 (rank : 19)
Query Neighborhood Hits	117	Target Neighborhood Hits	99	Shared Neighborhood Hits	64
SwissProt Accessions	Q13608, Q8WYQ2, Q99476	Gene names	PEX6, PXAAA1
Domain Architecture
Description	Peroxisome assembly factor 2 (PAF-2) (Peroxisomal-type ATPase 1) (Peroxin-6) (Peroxisomal biogenesis factor 6).

PEX6_MOUSE
NC score	0.938122 (rank : 27)	θ value	3.15612e-45 (rank : 22)
Query Neighborhood Hits	117	Target Neighborhood Hits	94	Shared Neighborhood Hits	61
SwissProt Accessions	Q99LC9, Q6YNQ9	Gene names	Pex6
Domain Architecture	No domain graphic available
Description	Peroxisome assembly factor 2 (PAF-2) (Peroxisomal-type ATPase 1) (Peroxin-6) (Peroxisomal biogenesis factor 6).

KATL1_HUMAN
NC score	0.930187 (rank : 28)	θ value	3.61106e-41 (rank : 28)
Query Neighborhood Hits	117	Target Neighborhood Hits	80	Shared Neighborhood Hits	64
SwissProt Accessions	Q9BW62	Gene names	KATNAL1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A-like 1 (EC 3.6.4.3) (Katanin p60 subunit A-like 1) (p60 katanin-like 1).

KATL1_MOUSE
NC score	0.929876 (rank : 29)	θ value	1.51715e-39 (rank : 31)
Query Neighborhood Hits	117	Target Neighborhood Hits	77	Shared Neighborhood Hits	64
SwissProt Accessions	Q8K0T4	Gene names	Katnal1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A-like 1 (EC 3.6.4.3) (Katanin p60 subunit A-like 1) (p60 katanin-like 1).

KTNA1_HUMAN
NC score	0.927278 (rank : 30)	θ value	1.2411e-41 (rank : 26)
Query Neighborhood Hits	117	Target Neighborhood Hits	117	Shared Neighborhood Hits	63
SwissProt Accessions	O75449, Q5TFA8, Q5TFA9, Q86VN2, Q9NU52	Gene names	KATNA1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A1 (EC 3.6.4.3) (Katanin p60 subunit A1) (p60 katanin).

NSF_MOUSE
NC score	0.926847 (rank : 31)	θ value	3.4976e-36 (rank : 33)
Query Neighborhood Hits	117	Target Neighborhood Hits	73	Shared Neighborhood Hits	61
SwissProt Accessions	P46460	Gene names	Nsf, Skd2
Domain Architecture
Description	Vesicle-fusing ATPase (EC 3.6.4.6) (Vesicular-fusion protein NSF) (N- ethylmaleimide sensitive fusion protein) (NEM-sensitive fusion protein) (SKD2 protein).

NSF_HUMAN
NC score	0.926538 (rank : 32)	θ value	2.05049e-36 (rank : 32)
Query Neighborhood Hits	117	Target Neighborhood Hits	74	Shared Neighborhood Hits	63
SwissProt Accessions	P46459, Q9UKZ2	Gene names	NSF
Domain Architecture
Description	Vesicle-fusing ATPase (EC 3.6.4.6) (Vesicular-fusion protein NSF) (N- ethylmaleimide sensitive fusion protein) (NEM-sensitive fusion protein).

KTNA1_MOUSE
NC score	0.925077 (rank : 33)	θ value	2.76489e-41 (rank : 27)
Query Neighborhood Hits	117	Target Neighborhood Hits	123	Shared Neighborhood Hits	63
SwissProt Accessions	Q9WV86	Gene names	Katna1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A1 (EC 3.6.4.3) (Katanin p60 subunit A1) (p60 katanin) (Lipotransin).

SPAST_HUMAN
NC score	0.920727 (rank : 34)	θ value	1.12514e-34 (rank : 34)
Query Neighborhood Hits	117	Target Neighborhood Hits	100	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UBP0, Q9UPR9	Gene names	SPAST, KIAA1083, SPG4
Domain Architecture
Description	Spastin.

SPAST_MOUSE
NC score	0.919217 (rank : 35)	θ value	1.12514e-34 (rank : 35)
Query Neighborhood Hits	117	Target Neighborhood Hits	138	Shared Neighborhood Hits	61
SwissProt Accessions	Q9QYY8, Q6ZPY6, Q80VE0, Q9CVK0	Gene names	Spast, Kiaa1083, Spg4
Domain Architecture	No domain graphic available
Description	Spastin.

VPS4B_HUMAN
NC score	0.911554 (rank : 36)	θ value	4.00176e-32 (rank : 40)
Query Neighborhood Hits	117	Target Neighborhood Hits	87	Shared Neighborhood Hits	61
SwissProt Accessions	O75351, Q9GZS7	Gene names	VPS4B, SKD1, VPS42
Domain Architecture
Description	Vacuolar protein sorting-associating protein 4B (Protein SKD1).

VPS4B_MOUSE
NC score	0.911029 (rank : 37)	θ value	1.52067e-31 (rank : 41)
Query Neighborhood Hits	117	Target Neighborhood Hits	86	Shared Neighborhood Hits	60
SwissProt Accessions	P46467, Q91W22, Q9R1C9	Gene names	Vps4b, Skd1
Domain Architecture
Description	Vacuolar protein sorting-associating protein 4B (Protein SKD1).

VPS4A_HUMAN
NC score	0.909272 (rank : 38)	θ value	2.77131e-33 (rank : 38)
Query Neighborhood Hits	117	Target Neighborhood Hits	95	Shared Neighborhood Hits	61
SwissProt Accessions	Q9UN37, Q8TF07, Q9UI03, Q9Y582	Gene names	VPS4A, VPS4
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associating protein 4A (SKD2 protein) (hVPS4) (VPS4-1).

VPS4A_MOUSE
NC score	0.909253 (rank : 39)	θ value	2.77131e-33 (rank : 39)
Query Neighborhood Hits	117	Target Neighborhood Hits	94	Shared Neighborhood Hits	61
SwissProt Accessions	Q8VEJ9, Q3TXT2	Gene names	Vps4a
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associating protein 4A.

ATAD2_MOUSE
NC score	0.896276 (rank : 40)	θ value	1.73182e-43 (rank : 25)
Query Neighborhood Hits	117	Target Neighborhood Hits	167	Shared Neighborhood Hits	57
SwissProt Accessions	Q8CDM1	Gene names	Atad2
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 2.

ATAD2_HUMAN
NC score	0.879506 (rank : 41)	θ value	2.67181e-44 (rank : 24)
Query Neighborhood Hits	117	Target Neighborhood Hits	322	Shared Neighborhood Hits	62
SwissProt Accessions	Q6PL18, Q658P2, Q68CQ0, Q6PJV6, Q8N890, Q9UHS5	Gene names	ATAD2
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 2.

FIGN_MOUSE
NC score	0.874216 (rank : 42)	θ value	3.87602e-27 (rank : 42)
Query Neighborhood Hits	117	Target Neighborhood Hits	165	Shared Neighborhood Hits	55
SwissProt Accessions	Q9ERZ6, Q3TPB0, Q3UP57, Q6PCM0	Gene names	Fign
Domain Architecture	No domain graphic available
Description	Fidgetin.

FIGN_HUMAN
NC score	0.868451 (rank : 43)	θ value	1.47289e-26 (rank : 43)
Query Neighborhood Hits	117	Target Neighborhood Hits	176	Shared Neighborhood Hits	55
SwissProt Accessions	Q5HY92, Q9H6M5, Q9NVZ9	Gene names	FIGN
Domain Architecture	No domain graphic available
Description	Fidgetin.

BCS1_HUMAN
NC score	0.718335 (rank : 44)	θ value	4.59992e-12 (rank : 45)
Query Neighborhood Hits	117	Target Neighborhood Hits	61	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y276, Q7Z2V7	Gene names	BCS1L, BCS1
Domain Architecture
Description	Mitochondrial chaperone BCS1 (BCS1-like protein) (H-BCS1).

BCS1_MOUSE
NC score	0.710968 (rank : 45)	θ value	1.2105e-12 (rank : 44)
Query Neighborhood Hits	117	Target Neighborhood Hits	64	Shared Neighborhood Hits	50
SwissProt Accessions	Q9CZP5	Gene names	Bcs1l
Domain Architecture
Description	Mitochondrial chaperone BCS1 (BCS1-like protein).

TRP13_MOUSE
NC score	0.710382 (rank : 46)	θ value	2.36244e-08 (rank : 49)
Query Neighborhood Hits	117	Target Neighborhood Hits	81	Shared Neighborhood Hits	57
SwissProt Accessions	Q3UA06, Q3UQG6, Q9CWW8	Gene names	Trip13
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 13 (Thyroid hormone receptor interactor 13) (Trip-13).

TRP13_HUMAN
NC score	0.706895 (rank : 47)	θ value	5.26297e-08 (rank : 50)
Query Neighborhood Hits	117	Target Neighborhood Hits	81	Shared Neighborhood Hits	58
SwissProt Accessions	Q15645, O15324	Gene names	TRIP13
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 13 (Thyroid hormone receptor interactor 13) (Trip-13) (Human papillomavirus type 16 E1 protein- binding protein) (HPV16 E1 protein-binding protein) (16E1-BP).

ATD3A_HUMAN
NC score	0.637878 (rank : 48)	θ value	2.36244e-08 (rank : 48)
Query Neighborhood Hits	117	Target Neighborhood Hits	248	Shared Neighborhood Hits	61
SwissProt Accessions	Q9NVI7, Q8N275, Q96A50	Gene names	ATAD3A
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3A.

ATD3B_HUMAN
NC score	0.629192 (rank : 49)	θ value	4.30538e-10 (rank : 46)
Query Neighborhood Hits	117	Target Neighborhood Hits	340	Shared Neighborhood Hits	62
SwissProt Accessions	Q5T9A4, Q6ZRB5, Q9BUK4, Q9ULE7	Gene names	ATAD3B, KIAA1273
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3B.

ATAD3_MOUSE
NC score	0.619934 (rank : 50)	θ value	2.79066e-09 (rank : 47)
Query Neighborhood Hits	117	Target Neighborhood Hits	326	Shared Neighborhood Hits	64
SwissProt Accessions	Q925I1, Q3UE74, Q69ZM7, Q8C6C6	Gene names	Atad3, Atad3a, Kiaa1273
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3 (AAA-ATPase TOB3).

CLPX_HUMAN
NC score	0.459857 (rank : 51)	θ value	1.87187e-05 (rank : 51)
Query Neighborhood Hits	117	Target Neighborhood Hits	72	Shared Neighborhood Hits	51
SwissProt Accessions	O76031, Q9H4D9	Gene names	CLPX
Domain Architecture
Description	ATP-dependent Clp protease ATP-binding subunit ClpX-like, mitochondrial precursor.

CLPX_MOUSE
NC score	0.457928 (rank : 52)	θ value	1.87187e-05 (rank : 52)
Query Neighborhood Hits	117	Target Neighborhood Hits	73	Shared Neighborhood Hits	51
SwissProt Accessions	Q9JHS4, Q9WVD1	Gene names	Clpx
Domain Architecture
Description	ATP-dependent Clp protease ATP-binding subunit ClpX-like, mitochondrial precursor.

LONM_HUMAN
NC score	0.440437 (rank : 53)	θ value	0.00665767 (rank : 53)
Query Neighborhood Hits	117	Target Neighborhood Hits	130	Shared Neighborhood Hits	58
SwissProt Accessions	P36776, P36777, Q9UQ95	Gene names	PRSS15
Domain Architecture
Description	Lon protease homolog, mitochondrial precursor (EC 3.4.21.-) (Lon protease-like protein) (LONP) (LONHs).

RUVB1_HUMAN
NC score	0.318985 (rank : 54)	θ value	0.125558 (rank : 57)
Query Neighborhood Hits	117	Target Neighborhood Hits	78	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Y265, Q9BSX9	Gene names	RUVBL1, NMP238, TIP49, TIP49A
Domain Architecture
Description	RuvB-like 1 (EC 3.6.1.-) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (TIP49a) (Pontin 52) (Nuclear matrix protein 238) (NMP 238) (54 kDa erythrocyte cytosolic protein) (ECP-54) (TIP60-associated protein 54-alpha) (TAP54-alpha).

RUVB1_MOUSE
NC score	0.318947 (rank : 55)	θ value	0.125558 (rank : 58)
Query Neighborhood Hits	117	Target Neighborhood Hits	78	Shared Neighborhood Hits	57
SwissProt Accessions	P60122, O35753	Gene names	Ruvbl1, Tip49, Tip49a
Domain Architecture
Description	RuvB-like 1 (EC 3.6.1.-) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (TIP49a) (Pontin 52) (DNA helicase p50).

WRIP1_MOUSE
NC score	0.235981 (rank : 56)	θ value	1.06291 (rank : 66)
Query Neighborhood Hits	117	Target Neighborhood Hits	93	Shared Neighborhood Hits	49
SwissProt Accessions	Q91XU0, Q3TCT7, Q6PDF0, Q8BUW5, Q8BWP6, Q8BY55, Q921W3, Q9EQL3	Gene names	Wrnip1, Whip
Domain Architecture	No domain graphic available
Description	ATPase WRNIP1 (Werner helicase-interacting protein 1).

WRIP1_HUMAN
NC score	0.232252 (rank : 57)	θ value	1.81305 (rank : 81)
Query Neighborhood Hits	117	Target Neighborhood Hits	100	Shared Neighborhood Hits	48
SwissProt Accessions	Q96S55, Q53EP6, Q59ET8, Q5W0E2, Q5W0E4, Q8WV26, Q9H681, Q9NRJ6	Gene names	WRNIP1, WHIP
Domain Architecture	No domain graphic available
Description	ATPase WRNIP1 (Werner helicase-interacting protein 1).

RFC1_MOUSE
NC score	0.130389 (rank : 58)	θ value	0.163984 (rank : 59)
Query Neighborhood Hits	117	Target Neighborhood Hits	290	Shared Neighborhood Hits	49
SwissProt Accessions	P35601	Gene names	Rfc1, Ibf-1, Recc1
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (A1-P145) (Differentiation- specific element-binding protein) (ISRE-binding protein).

RUVB2_HUMAN
NC score	0.126406 (rank : 59)	θ value	1.38821 (rank : 75)
Query Neighborhood Hits	117	Target Neighborhood Hits	43	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Y230, Q6PK27, Q9Y361	Gene names	RUVBL2, TIP48, TIP49B
Domain Architecture
Description	RuvB-like 2 (EC 3.6.1.-) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (TIP49b) (Repressing pontin 52) (Reptin 52) (51 kDa erythrocyte cytosolic protein) (ECP-51) (TIP60-associated protein 54-beta) (TAP54-beta).

RUVB2_MOUSE
NC score	0.123826 (rank : 60)	θ value	1.38821 (rank : 76)
Query Neighborhood Hits	117	Target Neighborhood Hits	42	Shared Neighborhood Hits	38
SwissProt Accessions	Q9WTM5	Gene names	Ruvbl2
Domain Architecture
Description	RuvB-like 2 (EC 3.6.1.-) (p47 protein).

THNSL_MOUSE
NC score	0.118146 (rank : 61)	θ value	1.38821 (rank : 78)
Query Neighborhood Hits	117	Target Neighborhood Hits	47	Shared Neighborhood Hits	32
SwissProt Accessions	Q8BH55	Gene names	Thnsl1
Domain Architecture	No domain graphic available
Description	Threonine synthase-like 1.

THNSL_HUMAN
NC score	0.115815 (rank : 62)	θ value	1.38821 (rank : 77)
Query Neighborhood Hits	117	Target Neighborhood Hits	47	Shared Neighborhood Hits	35
SwissProt Accessions	Q8IYQ7, Q5VV21	Gene names	THNSL1
Domain Architecture	No domain graphic available
Description	Threonine synthase-like 1.

RFC1_HUMAN
NC score	0.115106 (rank : 63)	θ value	0.62314 (rank : 62)
Query Neighborhood Hits	117	Target Neighborhood Hits	352	Shared Neighborhood Hits	45
SwissProt Accessions	P35251, Q5XKF5, Q6PKU0, Q86V41, Q86V46	Gene names	RFC1, RFC140
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (DNA-binding protein PO-GA).

RFC4_HUMAN
NC score	0.095602 (rank : 64)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	117	Target Neighborhood Hits	64	Shared Neighborhood Hits	41
SwissProt Accessions	P35249, Q6FHX7	Gene names	RFC4
Domain Architecture
Description	Replication factor C subunit 4 (Replication factor C 37 kDa subunit) (RF-C 37 kDa subunit) (RFC37) (Activator 1 37 kDa subunit) (A1 37 kDa subunit).

KAD6_HUMAN
NC score	0.090955 (rank : 65)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	117	Target Neighborhood Hits	46	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Y3D8	Gene names	AK6
Domain Architecture
Description	Adenylate kinase isoenzyme 6 (EC 2.7.4.3) (ATP-AMP transphosphorylase 6).

RFC4_MOUSE
NC score	0.084139 (rank : 66)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	117	Target Neighborhood Hits	65	Shared Neighborhood Hits	41
SwissProt Accessions	Q99J62	Gene names	Rfc4
Domain Architecture	No domain graphic available
Description	Replication factor C subunit 4.

KAD6_MOUSE
NC score	0.069932 (rank : 67)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	117	Target Neighborhood Hits	34	Shared Neighborhood Hits	21
SwissProt Accessions	Q8VCP8	Gene names	Ak6
Domain Architecture	No domain graphic available
Description	Adenylate kinase isoenzyme 6 (EC 2.7.4.3) (ATP-AMP transphosphorylase 6).

RFC5_MOUSE
NC score	0.065920 (rank : 68)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	117	Target Neighborhood Hits	58	Shared Neighborhood Hits	33
SwissProt Accessions	Q9D0F6	Gene names	Rfc5
Domain Architecture
Description	Replication factor C subunit 5 (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36) (Activator 1 36 kDa subunit) (A1 36 kDa subunit).

RFC5_HUMAN
NC score	0.064481 (rank : 69)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	117	Target Neighborhood Hits	60	Shared Neighborhood Hits	31
SwissProt Accessions	P40937	Gene names	RFC5
Domain Architecture
Description	Replication factor C subunit 5 (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36) (Activator 1 36 kDa subunit) (A1 36 kDa subunit).

RENT1_MOUSE
NC score	0.045190 (rank : 70)	θ value	0.0961366 (rank : 54)
Query Neighborhood Hits	117	Target Neighborhood Hits	54	Shared Neighborhood Hits	12
SwissProt Accessions	Q9EPU0, Q99PR4	Gene names	Upf1, Rent1
Domain Architecture
Description	Regulator of nonsense transcripts 1 (EC 3.6.1.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up- frameshift suppressor 1 homolog) (mUpf1).

RENT1_HUMAN
NC score	0.043742 (rank : 71)	θ value	0.125558 (rank : 56)
Query Neighborhood Hits	117	Target Neighborhood Hits	51	Shared Neighborhood Hits	12
SwissProt Accessions	Q92900, O00239, O43343, Q86Z25, Q92842	Gene names	UPF1, KIAA0221, RENT1
Domain Architecture
Description	Regulator of nonsense transcripts 1 (EC 3.6.1.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up- frameshift suppressor 1 homolog) (hUpf1).

MDN1_HUMAN
NC score	0.043216 (rank : 72)	θ value	1.38821 (rank : 74)
Query Neighborhood Hits	117	Target Neighborhood Hits	662	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NU22, O15019	Gene names	MDN1, KIAA0301
Domain Architecture
Description	Midasin (MIDAS-containing protein).

K2C4_HUMAN
NC score	0.031551 (rank : 73)	θ value	0.21417 (rank : 60)
Query Neighborhood Hits	117	Target Neighborhood Hits	471	Shared Neighborhood Hits	39
SwissProt Accessions	P19013, Q6GTR8, Q96LA7, Q9BTL1	Gene names	KRT4, CYK4
Domain Architecture
Description	Keratin, type II cytoskeletal 4 (Cytokeratin-4) (CK-4) (Keratin-4) (K4).

MOV10_HUMAN
NC score	0.030479 (rank : 74)	θ value	5.27518 (rank : 104)
Query Neighborhood Hits	117	Target Neighborhood Hits	46	Shared Neighborhood Hits	15
SwissProt Accessions	Q9HCE1, Q8TEF0, Q9BSY3, Q9BUJ9	Gene names	MOV10, KIAA1631
Domain Architecture
Description	Putative helicase MOV-10 (EC 3.6.1.-) (Moloney leukemia virus 10 protein).

KRHB4_HUMAN
NC score	0.029890 (rank : 75)	θ value	2.36792 (rank : 84)
Query Neighborhood Hits	117	Target Neighborhood Hits	352	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NSB2	Gene names	KRTHB4
Domain Architecture
Description	Keratin, type II cuticular Hb4 (Hair keratin, type II Hb4).

K2C1_MOUSE
NC score	0.029889 (rank : 76)	θ value	1.81305 (rank : 79)
Query Neighborhood Hits	117	Target Neighborhood Hits	477	Shared Neighborhood Hits	40
SwissProt Accessions	P04104	Gene names	Krt1, Krt2-1
Domain Architecture
Description	Keratin, type II cytoskeletal 1 (Cytokeratin-1) (CK-1) (Keratin-1) (K1) (67 kDa cytokeratin).

KRHB5_HUMAN
NC score	0.029305 (rank : 77)	θ value	2.36792 (rank : 85)
Query Neighborhood Hits	117	Target Neighborhood Hits	321	Shared Neighborhood Hits	33
SwissProt Accessions	P78386, Q9NSB1	Gene names	KRTHB5
Domain Architecture
Description	Keratin, type II cuticular Hb5 (Hair keratin, type II Hb5).

KRHB5_MOUSE
NC score	0.029287 (rank : 78)	θ value	5.27518 (rank : 102)
Query Neighborhood Hits	117	Target Neighborhood Hits	294	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Z2T6, Q8CE83, Q9D7M4	Gene names	Krthb5, Krt2-18
Domain Architecture
Description	Keratin, type II cuticular Hb5 (Hair keratin, type II Hb5).

KRHB3_HUMAN
NC score	0.029173 (rank : 79)	θ value	1.38821 (rank : 71)
Query Neighborhood Hits	117	Target Neighborhood Hits	438	Shared Neighborhood Hits	34
SwissProt Accessions	P78385, Q9NSB3	Gene names	KRTHB3
Domain Architecture
Description	Keratin, type II cuticular Hb3 (Hair keratin, type II Hb3).

KRHB1_HUMAN
NC score	0.029038 (rank : 80)	θ value	1.38821 (rank : 70)
Query Neighborhood Hits	117	Target Neighborhood Hits	461	Shared Neighborhood Hits	35
SwissProt Accessions	Q14533, Q14846, Q16274, Q8WU52, Q9BR74	Gene names	KRTHB1, MLN137
Domain Architecture
Description	Keratin, type II cuticular Hb1 (Hair keratin, type II Hb1) (ghHKb1) (ghHb1) (MLN 137).

KRHB6_HUMAN
NC score	0.029026 (rank : 81)	θ value	1.38821 (rank : 72)
Query Neighborhood Hits	117	Target Neighborhood Hits	447	Shared Neighborhood Hits	35
SwissProt Accessions	O43790, P78387	Gene names	KRTHB6
Domain Architecture
Description	Keratin, type II cuticular Hb6 (Hair keratin, type II Hb6) (ghHb6).

K2C1B_MOUSE
NC score	0.028934 (rank : 82)	θ value	2.36792 (rank : 83)
Query Neighborhood Hits	117	Target Neighborhood Hits	503	Shared Neighborhood Hits	39
SwissProt Accessions	Q6IFZ6	Gene names	Krt1b
Domain Architecture	No domain graphic available
Description	Keratin, type II cytoskeletal 1b (Type II keratin Kb39) (Embryonic type II keratin-1).

K22E_HUMAN
NC score	0.028855 (rank : 83)	θ value	1.38821 (rank : 67)
Query Neighborhood Hits	117	Target Neighborhood Hits	515	Shared Neighborhood Hits	38
SwissProt Accessions	P35908	Gene names	KRT2A, KRT2E
Domain Architecture
Description	Keratin, type II cytoskeletal 2 epidermal (Cytokeratin-2e) (K2e) (CK 2e).

K2C6A_MOUSE
NC score	0.028724 (rank : 84)	θ value	3.0926 (rank : 86)
Query Neighborhood Hits	117	Target Neighborhood Hits	481	Shared Neighborhood Hits	39
SwissProt Accessions	P50446, Q9Z332	Gene names	Krt6a, Ker2, Krt2-6, Krt2-6a, Krt6
Domain Architecture
Description	Keratin, type II cytoskeletal 6A (Cytokeratin-6A) (CK 6A) (K6a keratin) (Keratin-6 alpha) (mK6-alpha).

KRHB6_MOUSE
NC score	0.028652 (rank : 85)	θ value	5.27518 (rank : 103)
Query Neighborhood Hits	117	Target Neighborhood Hits	413	Shared Neighborhood Hits	36
SwissProt Accessions	P97861, Q3TTV9	Gene names	Krthb6, Krt2-10
Domain Architecture	No domain graphic available
Description	Keratin, type II cuticular Hb6 (Hair keratin, type II Hb6).

K2C6B_MOUSE
NC score	0.028627 (rank : 86)	θ value	3.0926 (rank : 87)
Query Neighborhood Hits	117	Target Neighborhood Hits	506	Shared Neighborhood Hits	39
SwissProt Accessions	Q9Z331	Gene names	Krt6b, K6-beta, Krt2-6b
Domain Architecture	No domain graphic available
Description	Keratin, type II cytoskeletal 6B (Cytokeratin-6B) (CK 6B) (K6b keratin) (Keratin-6 beta) (mK6-beta).

K2C6A_HUMAN
NC score	0.028598 (rank : 87)	θ value	4.03905 (rank : 92)
Query Neighborhood Hits	117	Target Neighborhood Hits	505	Shared Neighborhood Hits	41
SwissProt Accessions	P02538, Q6NT67, Q96CL4	Gene names	KRT6A, K6A
Domain Architecture
Description	Keratin, type II cytoskeletal 6A (Cytokeratin-6A) (CK 6A) (K6a keratin).

K2C6B_HUMAN
NC score	0.028558 (rank : 88)	θ value	4.03905 (rank : 93)
Query Neighborhood Hits	117	Target Neighborhood Hits	526	Shared Neighborhood Hits	40
SwissProt Accessions	P04259, P48669	Gene names	KRT6B, K6B
Domain Architecture
Description	Keratin, type II cytoskeletal 6B (Cytokeratin-6B) (CK 6B) (K6b keratin).

K2C6C_HUMAN
NC score	0.028538 (rank : 89)	θ value	4.03905 (rank : 94)
Query Neighborhood Hits	117	Target Neighborhood Hits	503	Shared Neighborhood Hits	41
SwissProt Accessions	P48666	Gene names	KRT6C
Domain Architecture
Description	Keratin, type II cytoskeletal 6C (Cytokeratin-6C) (CK 6C) (K6c keratin).

K2C6E_HUMAN
NC score	0.028509 (rank : 90)	θ value	4.03905 (rank : 95)
Query Neighborhood Hits	117	Target Neighborhood Hits	516	Shared Neighborhood Hits	40
SwissProt Accessions	P48668, Q7RTN9	Gene names	KRT6E
Domain Architecture
Description	Keratin, type II cytoskeletal 6E (Cytokeratin-6E) (CK 6E) (K6e keratin) (Keratin K6h).

K2C4_MOUSE
NC score	0.028371 (rank : 91)	θ value	1.38821 (rank : 69)
Query Neighborhood Hits	117	Target Neighborhood Hits	521	Shared Neighborhood Hits	39
SwissProt Accessions	P07744, Q6P3F5	Gene names	Krt4, Krt2-4
Domain Architecture
Description	Keratin, type II cytoskeletal 4 (Cytokeratin-4) (CK-4) (Keratin-4) (K4) (Cytoskeletal 57 kDa keratin).

KRHB4_MOUSE
NC score	0.028131 (rank : 92)	θ value	8.99809 (rank : 113)
Query Neighborhood Hits	117	Target Neighborhood Hits	344	Shared Neighborhood Hits	36
SwissProt Accessions	Q99M73	Gene names	Krthb4, Krt2-16
Domain Architecture
Description	Keratin, type II cuticular Hb4 (Hair keratin, type II Hb4) (65 kDa type II keratin).

K22O_HUMAN
NC score	0.028121 (rank : 93)	θ value	5.27518 (rank : 99)
Query Neighborhood Hits	117	Target Neighborhood Hits	485	Shared Neighborhood Hits	39
SwissProt Accessions	Q01546, Q7Z795	Gene names	KRT76, KRT2B, KRT2P
Domain Architecture
Description	Keratin, type II cytoskeletal 2 oral (Cytokeratin-2P) (K2P) (CK 2P) (Keratin 76).

K2C1_HUMAN
NC score	0.027957 (rank : 94)	θ value	1.38821 (rank : 68)
Query Neighborhood Hits	117	Target Neighborhood Hits	624	Shared Neighborhood Hits	40
SwissProt Accessions	P04264, Q14720, Q6GSJ0, Q9H298	Gene names	KRT1, KRTA
Domain Architecture
Description	Keratin, type II cytoskeletal 1 (Cytokeratin-1) (CK-1) (Keratin-1) (K1) (67 kDa cytokeratin) (Hair alpha protein).

K2C5_MOUSE
NC score	0.027945 (rank : 95)	θ value	5.27518 (rank : 101)
Query Neighborhood Hits	117	Target Neighborhood Hits	505	Shared Neighborhood Hits	40
SwissProt Accessions	Q922U2, Q920F2	Gene names	Krt5, Krt2-5
Domain Architecture	No domain graphic available
Description	Keratin, type II cytoskeletal 5 (Cytokeratin-5) (CK-5) (Keratin-5) (K5).

K2C5_HUMAN
NC score	0.027853 (rank : 96)	θ value	5.27518 (rank : 100)
Query Neighborhood Hits	117	Target Neighborhood Hits	506	Shared Neighborhood Hits	40
SwissProt Accessions	P13647, Q6PI71, Q6UBJ0, Q8TA91	Gene names	KRT5
Domain Architecture
Description	Keratin, type II cytoskeletal 5 (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (58 kDa cytokeratin).

K2C8_MOUSE
NC score	0.027670 (rank : 97)	θ value	1.06291 (rank : 65)
Query Neighborhood Hits	117	Target Neighborhood Hits	576	Shared Neighborhood Hits	40
SwissProt Accessions	P11679, Q3KQK5, Q3TGI1, Q3TJE1, Q3TKY7, Q61463, Q61518, Q61519	Gene names	Krt8, Krt2-8
Domain Architecture
Description	Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Cytokeratin endo A).

K2C8_HUMAN
NC score	0.026566 (rank : 98)	θ value	4.03905 (rank : 96)
Query Neighborhood Hits	117	Target Neighborhood Hits	593	Shared Neighborhood Hits	40
SwissProt Accessions	P05787, Q14099, Q14716, Q14717, Q53GJ0, Q6DHW5, Q6GMY0, Q96J60	Gene names	KRT8, CYK8
Domain Architecture
Description	Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8).

MOV10_MOUSE
NC score	0.025986 (rank : 99)	θ value	5.27518 (rank : 105)
Query Neighborhood Hits	117	Target Neighborhood Hits	39	Shared Neighborhood Hits	12
SwissProt Accessions	P23249, Q9DC64	Gene names	Mov10, Gb110
Domain Architecture
Description	Putative helicase MOV-10 (EC 3.6.1.-) (Moloney leukemia virus 10 protein).

M10L1_MOUSE
NC score	0.024025 (rank : 100)	θ value	1.38821 (rank : 73)
Query Neighborhood Hits	117	Target Neighborhood Hits	59	Shared Neighborhood Hits	7
SwissProt Accessions	Q99MV5, Q7TPA9, Q8C3W0, Q924C2	Gene names	Mov10l1, Champ
Domain Architecture
Description	Putative helicase Mov10l1 (EC 3.6.1.-) (Moloney leukemia virus 10-like protein 1) (MOV10-like 1) (Cardiac helicase activated by MEF2 protein) (Cardiac-specific RNA helicase).

TXLNG_MOUSE
NC score	0.018432 (rank : 101)	θ value	1.81305 (rank : 80)
Query Neighborhood Hits	117	Target Neighborhood Hits	552	Shared Neighborhood Hits	37
SwissProt Accessions	Q8BHN1, Q8BP11	Gene names	Txlng
Domain Architecture	No domain graphic available
Description	Gamma-taxilin.

TXLNG_HUMAN
NC score	0.016718 (rank : 102)	θ value	4.03905 (rank : 97)
Query Neighborhood Hits	117	Target Neighborhood Hits	568	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NUQ3, Q9P0X1	Gene names	TXLNG, CXorf15, LSR5
Domain Architecture	No domain graphic available
Description	Gamma-taxilin (Lipopolysaccharide-specific response protein 5).

PCNT_HUMAN
NC score	0.013726 (rank : 103)	θ value	0.365318 (rank : 61)
Query Neighborhood Hits	117	Target Neighborhood Hits	1551	Shared Neighborhood Hits	46
SwissProt Accessions	O95613, O43152, Q7Z7C9	Gene names	PCNT, KIAA0402, PCNT2
Domain Architecture
Description	Pericentrin (Pericentrin B) (Kendrin).

TBCD4_HUMAN
NC score	0.013662 (rank : 104)	θ value	0.813845 (rank : 63)
Query Neighborhood Hits	117	Target Neighborhood Hits	357	Shared Neighborhood Hits	13
SwissProt Accessions	O60343, Q5W0B9	Gene names	TBC1D4, KIAA0603
Domain Architecture	No domain graphic available
Description	TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160).

RT15_MOUSE
NC score	0.013125 (rank : 105)	θ value	6.88961 (rank : 109)
Query Neighborhood Hits	117	Target Neighborhood Hits	50	Shared Neighborhood Hits	6
SwissProt Accessions	Q9DC71, Q7TMG9, Q8C7F1, Q9CVE0, Q9CWX1	Gene names	Mrps15, Rpms15
Domain Architecture
Description	28S ribosomal protein S15, mitochondrial precursor (S15mt) (MRP-S15).

CR034_HUMAN
NC score	0.011148 (rank : 106)	θ value	4.03905 (rank : 91)
Query Neighborhood Hits	117	Target Neighborhood Hits	538	Shared Neighborhood Hits	35
SwissProt Accessions	Q5BJE1, Q6ZP67, Q6ZU20	Gene names	C18orf34
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C18orf34.

GOGA4_HUMAN
NC score	0.011075 (rank : 107)	θ value	0.125558 (rank : 55)
Query Neighborhood Hits	117	Target Neighborhood Hits	2034	Shared Neighborhood Hits	51
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

TPR_HUMAN
NC score	0.011068 (rank : 108)	θ value	3.0926 (rank : 89)
Query Neighborhood Hits	117	Target Neighborhood Hits	1921	Shared Neighborhood Hits	49
SwissProt Accessions	P12270, Q15655	Gene names	TPR
Domain Architecture
Description	Nucleoprotein TPR.

CING_HUMAN
NC score	0.009311 (rank : 109)	θ value	1.06291 (rank : 64)
Query Neighborhood Hits	117	Target Neighborhood Hits	1275	Shared Neighborhood Hits	44
SwissProt Accessions	Q9P2M7, Q5T386, Q9NR25	Gene names	CGN, KIAA1319
Domain Architecture
Description	Cingulin.

RBP22_HUMAN
NC score	0.008428 (rank : 110)	θ value	8.99809 (rank : 117)
Query Neighborhood Hits	117	Target Neighborhood Hits	165	Shared Neighborhood Hits	8
SwissProt Accessions	Q53T03, Q53QN2, Q59GM7	Gene names	RANBP2L2
Domain Architecture	No domain graphic available
Description	Ran-binding protein 2-like 2 (RanBP2L2).

IMA7_MOUSE
NC score	0.008086 (rank : 111)	θ value	2.36792 (rank : 82)
Query Neighborhood Hits	117	Target Neighborhood Hits	50	Shared Neighborhood Hits	4
SwissProt Accessions	O35345, Q9CVP9	Gene names	Kpna6, Kpna5
Domain Architecture
Description	Importin alpha-7 subunit (Karyopherin alpha-6 subunit) (Importin alpha S2).

PIBF1_HUMAN
NC score	0.008013 (rank : 112)	θ value	3.0926 (rank : 88)
Query Neighborhood Hits	117	Target Neighborhood Hits	1041	Shared Neighborhood Hits	34
SwissProt Accessions	Q8WXW3, O95664, Q6U9V2, Q6UG50, Q86V07, Q96SF4	Gene names	PIBF1, C13orf24, PIBF
Domain Architecture
Description	Progesterone-induced-blocking factor 1.

NUP88_MOUSE
NC score	0.007442 (rank : 113)	θ value	8.99809 (rank : 116)
Query Neighborhood Hits	117	Target Neighborhood Hits	239	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CEC0, Q80Z13, Q8K090	Gene names	Nup88
Domain Architecture	No domain graphic available
Description	Nuclear pore complex protein Nup88 (Nucleoporin Nup88) (88 kDa nuclear pore complex protein).

COG3_HUMAN
NC score	0.007143 (rank : 114)	θ value	8.99809 (rank : 110)
Query Neighborhood Hits	117	Target Neighborhood Hits	56	Shared Neighborhood Hits	5
SwissProt Accessions	Q96JB2, Q5VT70, Q8IXX4, Q9BZ92	Gene names	COG3, SEC34
Domain Architecture
Description	Conserved oligomeric Golgi complex component 3 (Vesicle docking protein SEC34 homolog) (p94).

HOOK3_MOUSE
NC score	0.006919 (rank : 115)	θ value	5.27518 (rank : 98)
Query Neighborhood Hits	117	Target Neighborhood Hits	1007	Shared Neighborhood Hits	35
SwissProt Accessions	Q8BUK6, Q8BV48, Q8BW57, Q8BY41	Gene names	Hook3
Domain Architecture
Description	Hook homolog 3.

BICD1_MOUSE
NC score	0.006903 (rank : 116)	θ value	6.88961 (rank : 106)
Query Neighborhood Hits	117	Target Neighborhood Hits	837	Shared Neighborhood Hits	38
SwissProt Accessions	Q8BR07, O55206, Q8BQ18, Q8BRR8, Q8C4D3, Q8CAK6, Q8R2J4, Q8R2J5, Q8R2J6, Q91YP7	Gene names	Bicd1
Domain Architecture	No domain graphic available
Description	Cytoskeleton-like bicaudal D protein homolog 1.

GCP6_HUMAN
NC score	0.006850 (rank : 117)	θ value	8.99809 (rank : 111)
Query Neighborhood Hits	117	Target Neighborhood Hits	295	Shared Neighborhood Hits	8
SwissProt Accessions	Q96RT7, Q5JZ80, Q6PJ40, Q86YE9, Q9BY91, Q9UGX3, Q9UGX4	Gene names	TUBGCP6, GCP6, KIAA1669
Domain Architecture
Description	Gamma-tubulin complex component 6 (GCP-6).

CEP63_HUMAN
NC score	0.006705 (rank : 118)	θ value	4.03905 (rank : 90)
Query Neighborhood Hits	117	Target Neighborhood Hits	1005	Shared Neighborhood Hits	32
SwissProt Accessions	Q96MT8, Q96CR0, Q9H8F5, Q9H8N0	Gene names	CEP63
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 63 kDa (Cep63 protein).

RGPD8_HUMAN
NC score	0.005719 (rank : 119)	θ value	6.88961 (rank : 108)
Query Neighborhood Hits	117	Target Neighborhood Hits	135	Shared Neighborhood Hits	5
SwissProt Accessions	Q99666	Gene names	RGPD8, RANBP2L1
Domain Architecture	No domain graphic available
Description	RANBP2-like and GRIP domain-containing protein 8 (Ran-binding protein 2-like 1) (RanBP2L1) (Sperm membrane protein BS-63).

NALP5_MOUSE
NC score	0.005543 (rank : 120)	θ value	8.99809 (rank : 115)
Query Neighborhood Hits	117	Target Neighborhood Hits	560	Shared Neighborhood Hits	15
SwissProt Accessions	Q9R1M5, Q9JLR2	Gene names	Nalp5, Mater
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 5 (Maternal antigen that embryos require) (Mater protein) (Ooplasm-specific protein 1) (OP1).

MYH1_HUMAN
NC score	0.005187 (rank : 121)	θ value	6.88961 (rank : 107)
Query Neighborhood Hits	117	Target Neighborhood Hits	1478	Shared Neighborhood Hits	47
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH9_MOUSE
NC score	0.005124 (rank : 122)	θ value	8.99809 (rank : 114)
Query Neighborhood Hits	117	Target Neighborhood Hits	1829	Shared Neighborhood Hits	53
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

IQGA3_HUMAN
NC score	0.004419 (rank : 123)	θ value	8.99809 (rank : 112)
Query Neighborhood Hits	117	Target Neighborhood Hits	125	Shared Neighborhood Hits	6
SwissProt Accessions	Q86VI3	Gene names	IQGAP3
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP3.