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Network neighborhood for query Sequence : RENT1_HUMAN

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RENT1_HUMAN
SwissProt Accessions	Q92900, O00239, O43343, Q86Z25, Q92842	Gene names	UPF1, KIAA0221, RENT1
Domain Architecture
Description	Regulator of nonsense transcripts 1 (EC 3.6.1.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up- frameshift suppressor 1 homolog) (hUpf1).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RENT1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	51	Target Neighborhood Hits	51	Shared Neighborhood Hits	51
SwissProt Accessions	Q92900, O00239, O43343, Q86Z25, Q92842	Gene names	UPF1, KIAA0221, RENT1
Domain Architecture
Description	Regulator of nonsense transcripts 1 (EC 3.6.1.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up- frameshift suppressor 1 homolog) (hUpf1).

RENT1_MOUSE
θ value	0 (rank : 2)	NC score	0.998424 (rank : 2)
Query Neighborhood Hits	51	Target Neighborhood Hits	54	Shared Neighborhood Hits	44
SwissProt Accessions	Q9EPU0, Q99PR4	Gene names	Upf1, Rent1
Domain Architecture
Description	Regulator of nonsense transcripts 1 (EC 3.6.1.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up- frameshift suppressor 1 homolog) (mUpf1).

SMBP2_MOUSE
θ value	1.15895e-47 (rank : 3)	NC score	0.816595 (rank : 4)
Query Neighborhood Hits	51	Target Neighborhood Hits	104	Shared Neighborhood Hits	15
SwissProt Accessions	P40694	Gene names	Ighmbp2, Smbp-2, Smbp2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Cardiac transcription factor 1) (CATF1).

PR285_HUMAN
θ value	2.18568e-46 (rank : 4)	NC score	0.783493 (rank : 5)
Query Neighborhood Hits	51	Target Neighborhood Hits	63	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BYK8, Q3C2G2, Q4VXQ1, Q8TEF3, Q96ND3, Q9C094	Gene names	PRIC285, KIAA1769
Domain Architecture
Description	Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein (EC 3.6.1.-) (ATP-dependent helicase PRIC285) (PPAR-alpha- interacting complex protein 285) (PPAR-gamma DBD-interacting protein 1) (PDIP1).

SMBP2_HUMAN
θ value	2.18568e-46 (rank : 5)	NC score	0.816993 (rank : 3)
Query Neighborhood Hits	51	Target Neighborhood Hits	107	Shared Neighborhood Hits	15
SwissProt Accessions	P38935, Q00443, Q14177	Gene names	IGHMBP2, SMBP2, SMUBP2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Glial factor 1) (GF-1).

SETX_HUMAN
θ value	2.95404e-43 (rank : 6)	NC score	0.745540 (rank : 10)
Query Neighborhood Hits	51	Target Neighborhood Hits	368	Shared Neighborhood Hits	17
SwissProt Accessions	Q7Z333, O75120, Q3KQX4, Q68DW5, Q6AZD7, Q7Z3J6, Q8WX33, Q9H9D1, Q9NVP9	Gene names	SETX, ALS4, KIAA0625, SCAR1
Domain Architecture
Description	Probable helicase senataxin (EC 3.6.1.-) (SEN1 homolog).

MOV10_MOUSE
θ value	5.21438e-40 (rank : 7)	NC score	0.780021 (rank : 6)
Query Neighborhood Hits	51	Target Neighborhood Hits	39	Shared Neighborhood Hits	19
SwissProt Accessions	P23249, Q9DC64	Gene names	Mov10, Gb110
Domain Architecture
Description	Putative helicase MOV-10 (EC 3.6.1.-) (Moloney leukemia virus 10 protein).

MOV10_HUMAN
θ value	2.86122e-38 (rank : 8)	NC score	0.777065 (rank : 7)
Query Neighborhood Hits	51	Target Neighborhood Hits	46	Shared Neighborhood Hits	19
SwissProt Accessions	Q9HCE1, Q8TEF0, Q9BSY3, Q9BUJ9	Gene names	MOV10, KIAA1631
Domain Architecture
Description	Putative helicase MOV-10 (EC 3.6.1.-) (Moloney leukemia virus 10 protein).

M10L1_HUMAN
θ value	8.32485e-38 (rank : 9)	NC score	0.765880 (rank : 8)
Query Neighborhood Hits	51	Target Neighborhood Hits	36	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BXT6, Q5TGD5, Q8NBD4, Q9NXW3, Q9UFB3, Q9UGX9	Gene names	MOV10L1
Domain Architecture
Description	Putative helicase Mov10l1 (EC 3.6.1.-) (Moloney leukemia virus 10-like protein 1) (MOV10-like 1).

M10L1_MOUSE
θ value	2.42216e-37 (rank : 10)	NC score	0.762172 (rank : 9)
Query Neighborhood Hits	51	Target Neighborhood Hits	59	Shared Neighborhood Hits	19
SwissProt Accessions	Q99MV5, Q7TPA9, Q8C3W0, Q924C2	Gene names	Mov10l1, Champ
Domain Architecture
Description	Putative helicase Mov10l1 (EC 3.6.1.-) (Moloney leukemia virus 10-like protein 1) (MOV10-like 1) (Cardiac helicase activated by MEF2 protein) (Cardiac-specific RNA helicase).

ZNFX1_MOUSE
θ value	5.22648e-32 (rank : 11)	NC score	0.569517 (rank : 14)
Query Neighborhood Hits	51	Target Neighborhood Hits	407	Shared Neighborhood Hits	17
SwissProt Accessions	Q8R151, Q3U016, Q3UD71, Q3UEZ0	Gene names	ZNFX1
Domain Architecture	No domain graphic available
Description	NFX1-type zinc finger-containing protein 1.

ZNFX1_HUMAN
θ value	4.42448e-31 (rank : 12)	NC score	0.567569 (rank : 15)
Query Neighborhood Hits	51	Target Neighborhood Hits	308	Shared Neighborhood Hits	16
SwissProt Accessions	Q9P2E3, Q9BQM7, Q9BQM8, Q9H8C1, Q9H9S2, Q9NUM1, Q9NWW1	Gene names	ZNFX1, KIAA1404
Domain Architecture	No domain graphic available
Description	NFX1-type zinc finger-containing protein 1.

HELZ_HUMAN
θ value	5.59698e-26 (rank : 13)	NC score	0.708934 (rank : 11)
Query Neighborhood Hits	51	Target Neighborhood Hits	198	Shared Neighborhood Hits	18
SwissProt Accessions	P42694	Gene names	HELZ, KIAA0054
Domain Architecture	No domain graphic available
Description	Probable helicase with zinc-finger domain (EC 3.6.1.-).

AQR_HUMAN
θ value	2.97466e-19 (rank : 14)	NC score	0.570851 (rank : 13)
Query Neighborhood Hits	51	Target Neighborhood Hits	88	Shared Neighborhood Hits	17
SwissProt Accessions	O60306, Q2YDX9, Q6IRU8, Q6PIC8	Gene names	AQR, KIAA0560
Domain Architecture	No domain graphic available
Description	Intron-binding protein aquarius (Intron-binding protein of 160 kDa) (IBP160).

AQR_MOUSE
θ value	2.97466e-19 (rank : 15)	NC score	0.574432 (rank : 12)
Query Neighborhood Hits	51	Target Neighborhood Hits	62	Shared Neighborhood Hits	17
SwissProt Accessions	Q8CFQ3, P97871, Q3U9N1, Q3ULE8, Q80TX8	Gene names	Aqr, Kiaa0560
Domain Architecture	No domain graphic available
Description	Intron-binding protein aquarius.

CAC1B_HUMAN
θ value	0.0961366 (rank : 16)	NC score	0.033509 (rank : 42)
Query Neighborhood Hits	51	Target Neighborhood Hits	257	Shared Neighborhood Hits	5
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

PRS8_HUMAN
θ value	0.125558 (rank : 17)	NC score	0.043742 (rank : 38)
Query Neighborhood Hits	51	Target Neighborhood Hits	117	Shared Neighborhood Hits	12
SwissProt Accessions	P62195, O35051, O43208, P47210, P52915, P52916	Gene names	PSMC5, SUG1
Domain Architecture
Description	26S protease regulatory subunit 8 (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (p45/SUG) (Thyroid hormone receptor- interacting protein 1) (TRIP1).

PRS8_MOUSE
θ value	0.125558 (rank : 18)	NC score	0.043742 (rank : 39)
Query Neighborhood Hits	51	Target Neighborhood Hits	117	Shared Neighborhood Hits	12
SwissProt Accessions	P62196, O35051, P47210, P52915, P52916, Q3UL51, Q9CWN5	Gene names	Psmc5, Sug1
Domain Architecture
Description	26S protease regulatory subunit 8 (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (p45/SUG) (mSUG1).

CAC1B_MOUSE
θ value	0.279714 (rank : 19)	NC score	0.028271 (rank : 45)
Query Neighborhood Hits	51	Target Neighborhood Hits	351	Shared Neighborhood Hits	4
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CT012_MOUSE
θ value	0.47712 (rank : 20)	NC score	0.040375 (rank : 40)
Query Neighborhood Hits	51	Target Neighborhood Hits	229	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C008, Q8C060	Gene names
Domain Architecture	No domain graphic available
Description	Protein C20orf12 homolog.

MLL3_HUMAN
θ value	0.62314 (rank : 21)	NC score	0.021939 (rank : 54)
Query Neighborhood Hits	51	Target Neighborhood Hits	1644	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

DLG7_HUMAN
θ value	0.813845 (rank : 22)	NC score	0.047965 (rank : 36)
Query Neighborhood Hits	51	Target Neighborhood Hits	53	Shared Neighborhood Hits	3
SwissProt Accessions	Q15398, Q8NG58	Gene names	DLG7, KIAA0008
Domain Architecture
Description	Discs large homolog 7 (Hepatoma up-regulated protein) (HURP).

UT14B_MOUSE
θ value	0.813845 (rank : 23)	NC score	0.037571 (rank : 41)
Query Neighborhood Hits	51	Target Neighborhood Hits	226	Shared Neighborhood Hits	8
SwissProt Accessions	Q6EJB6, Q6EJB5, Q8BL60	Gene names	Utp14b, Jsd
Domain Architecture	No domain graphic available
Description	U3 small nucleolar RNA-associated protein 14 homolog B (Juvenile spermatogonial depletion protein).

CO4A2_MOUSE
θ value	1.38821 (rank : 24)	NC score	0.006990 (rank : 65)
Query Neighborhood Hits	51	Target Neighborhood Hits	492	Shared Neighborhood Hits	5
SwissProt Accessions	P08122, Q61375	Gene names	Col4a2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

KIFA3_HUMAN
θ value	1.38821 (rank : 25)	NC score	0.024417 (rank : 49)
Query Neighborhood Hits	51	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q92845, Q8NHU7, Q9H416	Gene names	KIFAP3, SMAP
Domain Architecture
Description	Kinesin-associated protein 3 (Smg GDS-associated protein).

PEX1_HUMAN
θ value	1.38821 (rank : 26)	NC score	0.033155 (rank : 43)
Query Neighborhood Hits	51	Target Neighborhood Hits	98	Shared Neighborhood Hits	14
SwissProt Accessions	O43933, Q96S71, Q96S72, Q96S73, Q99994	Gene names	PEX1
Domain Architecture
Description	Peroxisome biogenesis factor 1 (Peroxin-1) (Peroxisome biogenesis disorder protein 1).

BIG1_HUMAN
θ value	1.81305 (rank : 27)	NC score	0.019741 (rank : 56)
Query Neighborhood Hits	51	Target Neighborhood Hits	76	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

CLAP2_HUMAN
θ value	1.81305 (rank : 28)	NC score	0.017900 (rank : 57)
Query Neighborhood Hits	51	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	O75122, Q7L8F6, Q8N6R6, Q9BQT3, Q9BQT4, Q9H7A3, Q9NSZ2	Gene names	CLASP2, KIAA0627
Domain Architecture	No domain graphic available
Description	CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2).

MTMR3_HUMAN
θ value	1.81305 (rank : 29)	NC score	0.016170 (rank : 58)
Query Neighborhood Hits	51	Target Neighborhood Hits	163	Shared Neighborhood Hits	3
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

MY18B_HUMAN
θ value	2.36792 (rank : 30)	NC score	0.007498 (rank : 64)
Query Neighborhood Hits	51	Target Neighborhood Hits	1299	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

NUBP1_MOUSE
θ value	2.36792 (rank : 31)	NC score	0.030980 (rank : 44)
Query Neighborhood Hits	51	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q9R060	Gene names	Nubp1
Domain Architecture
Description	Nucleotide-binding protein 1 (NBP 1).

CHD4_HUMAN
θ value	3.0926 (rank : 32)	NC score	0.012737 (rank : 60)
Query Neighborhood Hits	51	Target Neighborhood Hits	365	Shared Neighborhood Hits	5
SwissProt Accessions	Q14839, Q8IXZ5	Gene names	CHD4
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta).

CHD4_MOUSE
θ value	3.0926 (rank : 33)	NC score	0.012580 (rank : 61)
Query Neighborhood Hits	51	Target Neighborhood Hits	408	Shared Neighborhood Hits	5
SwissProt Accessions	Q6PDQ2	Gene names	Chd4
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 4 (CHD-4).

GALE_MOUSE
θ value	3.0926 (rank : 34)	NC score	0.027852 (rank : 46)
Query Neighborhood Hits	51	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R059	Gene names	Gale
Domain Architecture
Description	UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-galactose 4-epimerase).

FREM3_HUMAN
θ value	4.03905 (rank : 35)	NC score	0.008109 (rank : 63)
Query Neighborhood Hits	51	Target Neighborhood Hits	56	Shared Neighborhood Hits	2
SwissProt Accessions	P0C091	Gene names	FREM3
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 3 precursor.

PO121_MOUSE
θ value	4.03905 (rank : 36)	NC score	0.013068 (rank : 59)
Query Neighborhood Hits	51	Target Neighborhood Hits	345	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K3Z9, Q7TSH5	Gene names	Pom121, Nup121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa).

RFC4_HUMAN
θ value	4.03905 (rank : 37)	NC score	0.047193 (rank : 37)
Query Neighborhood Hits	51	Target Neighborhood Hits	64	Shared Neighborhood Hits	13
SwissProt Accessions	P35249, Q6FHX7	Gene names	RFC4
Domain Architecture
Description	Replication factor C subunit 4 (Replication factor C 37 kDa subunit) (RF-C 37 kDa subunit) (RFC37) (Activator 1 37 kDa subunit) (A1 37 kDa subunit).

RFC4_MOUSE
θ value	4.03905 (rank : 38)	NC score	0.049050 (rank : 35)
Query Neighborhood Hits	51	Target Neighborhood Hits	65	Shared Neighborhood Hits	13
SwissProt Accessions	Q99J62	Gene names	Rfc4
Domain Architecture	No domain graphic available
Description	Replication factor C subunit 4.

DAB2_MOUSE
θ value	5.27518 (rank : 39)	NC score	0.019834 (rank : 55)
Query Neighborhood Hits	51	Target Neighborhood Hits	163	Shared Neighborhood Hits	5
SwissProt Accessions	P98078, Q3U3K1, Q91W56, Q923E1	Gene names	Dab2, Doc2
Domain Architecture
Description	Disabled homolog 2 (DOC-2) (Mitogen-responsive phosphoprotein).

MYO5A_HUMAN
θ value	5.27518 (rank : 40)	NC score	0.003761 (rank : 67)
Query Neighborhood Hits	51	Target Neighborhood Hits	1092	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y4I1, O60653, Q07902, Q16249, Q9UE30, Q9UE31	Gene names	MYO5A, MYH12
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myoxin).

PRS4_HUMAN
θ value	5.27518 (rank : 41)	NC score	0.025380 (rank : 47)
Query Neighborhood Hits	51	Target Neighborhood Hits	84	Shared Neighborhood Hits	9
SwissProt Accessions	P62191, P49014, Q03527, Q6IAW0, Q96AZ3	Gene names	PSMC1
Domain Architecture
Description	26S protease regulatory subunit 4 (P26s4) (Proteasome 26S subunit ATPase 1).

PRS4_MOUSE
θ value	5.27518 (rank : 42)	NC score	0.025380 (rank : 48)
Query Neighborhood Hits	51	Target Neighborhood Hits	84	Shared Neighborhood Hits	9
SwissProt Accessions	P62192, P49014, Q03527, Q96AZ3	Gene names	Psmc1
Domain Architecture
Description	26S protease regulatory subunit 4 (P26s4) (Proteasome 26S subunit ATPase 1).

RALB_MOUSE
θ value	5.27518 (rank : 43)	NC score	0.004158 (rank : 66)
Query Neighborhood Hits	51	Target Neighborhood Hits	274	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JIW9, Q3TVS5	Gene names	Ralb
Domain Architecture
Description	Ras-related protein Ral-B.

HOOK3_HUMAN
θ value	6.88961 (rank : 44)	NC score	0.003567 (rank : 68)
Query Neighborhood Hits	51	Target Neighborhood Hits	1070	Shared Neighborhood Hits	7
SwissProt Accessions	Q86VS8, Q8NBH0, Q9BY13	Gene names	HOOK3
Domain Architecture
Description	Hook homolog 3 (hHK3).

NUBP1_HUMAN
θ value	6.88961 (rank : 45)	NC score	0.022300 (rank : 53)
Query Neighborhood Hits	51	Target Neighborhood Hits	16	Shared Neighborhood Hits	4
SwissProt Accessions	P53384	Gene names	NUBP1, NBP, NBP1
Domain Architecture
Description	Nucleotide-binding protein 1 (NBP 1).

CN115_HUMAN
θ value	8.99809 (rank : 46)	NC score	0.023153 (rank : 52)
Query Neighborhood Hits	51	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H8Y1, Q9NVC7	Gene names	C14orf115
Domain Architecture
Description	Uncharacterized protein C14orf115.

MDC1_MOUSE
θ value	8.99809 (rank : 47)	NC score	0.009679 (rank : 62)
Query Neighborhood Hits	51	Target Neighborhood Hits	998	Shared Neighborhood Hits	9
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

PRS6A_HUMAN
θ value	8.99809 (rank : 48)	NC score	0.023430 (rank : 51)
Query Neighborhood Hits	51	Target Neighborhood Hits	87	Shared Neighborhood Hits	11
SwissProt Accessions	P17980, Q96HD3	Gene names	PSMC3, TBP1
Domain Architecture
Description	26S protease regulatory subunit 6A (Proteasome 26S subunit ATPase 3) (TAT-binding protein 1) (TBP-1) (Proteasome subunit P50).

PRS6A_MOUSE
θ value	8.99809 (rank : 49)	NC score	0.023447 (rank : 50)
Query Neighborhood Hits	51	Target Neighborhood Hits	85	Shared Neighborhood Hits	11
SwissProt Accessions	O88685	Gene names	Psmc3, Tbp1
Domain Architecture
Description	26S protease regulatory subunit 6A (Proteasome 26S subunit ATPase 3) (TAT-binding protein 1) (TBP-1).

RAB21_HUMAN
θ value	8.99809 (rank : 50)	NC score	0.001600 (rank : 69)
Query Neighborhood Hits	51	Target Neighborhood Hits	270	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UL25, Q14466	Gene names	RAB21, KIAA0118
Domain Architecture
Description	Ras-related protein Rab-21.

RAB21_MOUSE
θ value	8.99809 (rank : 51)	NC score	0.001581 (rank : 70)
Query Neighborhood Hits	51	Target Neighborhood Hits	268	Shared Neighborhood Hits	4
SwissProt Accessions	P35282, Q7TPN7	Gene names	Rab21
Domain Architecture
Description	Ras-related protein Rab-21 (Rab-12).

CX048_HUMAN
θ value	θ > 10 (rank : 52)	NC score	0.199912 (rank : 16)
Query Neighborhood Hits	51	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WUE5, Q9NWY8	Gene names	CXorf48
Domain Architecture	No domain graphic available
Description	Protein CXorf48 (Tumor antigen BJ-HCC-20).

KRA98_HUMAN
θ value	θ > 10 (rank : 53)	NC score	0.051926 (rank : 31)
Query Neighborhood Hits	51	Target Neighborhood Hits	185	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BYQ0	Gene names	KRTAP9-8, KAP9.8, KRTAP9.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-8 (Keratin-associated protein 9.8) (Ultrahigh sulfur keratin-associated protein 9.8).

KRA99_HUMAN
θ value	θ > 10 (rank : 54)	NC score	0.050486 (rank : 33)
Query Neighborhood Hits	51	Target Neighborhood Hits	173	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BYP9	Gene names	KRTAP9-9, KAP9.9, KRTAP9.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-9 (Keratin-associated protein 9.9) (Ultrahigh sulfur keratin-associated protein 9.9).

LCE1D_HUMAN
θ value	θ > 10 (rank : 55)	NC score	0.050926 (rank : 32)
Query Neighborhood Hits	51	Target Neighborhood Hits	44	Shared Neighborhood Hits	2
SwissProt Accessions	Q5T752	Gene names	LCE1D, LEP4
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1D (Late envelope protein 4).

LCE2C_HUMAN
θ value	θ > 10 (rank : 56)	NC score	0.057317 (rank : 29)
Query Neighborhood Hits	51	Target Neighborhood Hits	53	Shared Neighborhood Hits	3
SwissProt Accessions	Q5TA81	Gene names	LCE2C, LEP11
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2C (Late envelope protein 11).

LCE2D_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.062447 (rank : 26)
Query Neighborhood Hits	51	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	Q5TA82	Gene names	LCE2D, LEP12, SPRL1A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2D (Late envelope protein 12) (Small proline-rich-like epidermal differentiation complex protein 1A).

LCE5A_HUMAN
θ value	θ > 10 (rank : 58)	NC score	0.059181 (rank : 27)
Query Neighborhood Hits	51	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	Q5TCM9	Gene names	LCE5A, LEP18, SPRL5A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 5A (Late envelope protein 18) (Small proline-rich-like epidermal differentiation complex protein 5A).

NFX1_HUMAN
θ value	θ > 10 (rank : 59)	NC score	0.058902 (rank : 28)
Query Neighborhood Hits	51	Target Neighborhood Hits	405	Shared Neighborhood Hits	5
SwissProt Accessions	Q12986	Gene names	NFX1
Domain Architecture
Description	Transcriptional repressor NF-X1 (EC 6.3.2.-) (Nuclear transcription factor, X box-binding, 1).

RRP44_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.067740 (rank : 24)
Query Neighborhood Hits	51	Target Neighborhood Hits	35	Shared Neighborhood Hits	1
SwissProt Accessions	Q9Y2L1, Q5W0P7, Q5W0P8, Q658Z7, Q7Z481, Q8WWI2, Q9UG36	Gene names	DIS3, KIAA1008, RRP44
Domain Architecture
Description	Exosome complex exonuclease RRP44 (EC 3.1.13.-) (Ribosomal RNA- processing protein 44) (DIS3 protein homolog).

SPR2B_HUMAN
θ value	θ > 10 (rank : 61)	NC score	0.052085 (rank : 30)
Query Neighborhood Hits	51	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	P35325, Q5T528	Gene names	SPRR2B
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2B (SPR-2B).

SPR2B_MOUSE
θ value	θ > 10 (rank : 62)	NC score	0.083161 (rank : 19)
Query Neighborhood Hits	51	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	O70554, Q7TSB2	Gene names	Sprr2b
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2B.

SPR2D_MOUSE
θ value	θ > 10 (rank : 63)	NC score	0.085290 (rank : 17)
Query Neighborhood Hits	51	Target Neighborhood Hits	61	Shared Neighborhood Hits	2
SwissProt Accessions	O70555	Gene names	Sprr2d
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2D.

SPR2E_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.077782 (rank : 21)
Query Neighborhood Hits	51	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	P22531, Q96RM2	Gene names	SPRR2E
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2E (SPR-2E) (Small proline-rich protein II) (SPR-II).

SPR2E_MOUSE
θ value	θ > 10 (rank : 65)	NC score	0.065521 (rank : 25)
Query Neighborhood Hits	51	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	O70556	Gene names	Sprr2e
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2E.

SPR2F_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.083384 (rank : 18)
Query Neighborhood Hits	51	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	Q96RM1	Gene names	SPRR2F
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2F (SPR-2F).

SPR2F_MOUSE
θ value	θ > 10 (rank : 67)	NC score	0.050250 (rank : 34)
Query Neighborhood Hits	51	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	O70557	Gene names	Sprr2f
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2F.

SPR2G_MOUSE
θ value	θ > 10 (rank : 68)	NC score	0.082735 (rank : 20)
Query Neighborhood Hits	51	Target Neighborhood Hits	53	Shared Neighborhood Hits	2
SwissProt Accessions	O70558	Gene names	Sprr2g
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2G.

SPR2H_MOUSE
θ value	θ > 10 (rank : 69)	NC score	0.073358 (rank : 22)
Query Neighborhood Hits	51	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	O70559	Gene names	Sprr2h
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2H.

SPR2I_MOUSE
θ value	θ > 10 (rank : 70)	NC score	0.068423 (rank : 23)
Query Neighborhood Hits	51	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	O70560	Gene names	Sprr2i
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2I.

Hits sorted by NC score

RENT1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	51	Target Neighborhood Hits	51	Shared Neighborhood Hits	51
SwissProt Accessions	Q92900, O00239, O43343, Q86Z25, Q92842	Gene names	UPF1, KIAA0221, RENT1
Domain Architecture
Description	Regulator of nonsense transcripts 1 (EC 3.6.1.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up- frameshift suppressor 1 homolog) (hUpf1).

RENT1_MOUSE
NC score	0.998424 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	51	Target Neighborhood Hits	54	Shared Neighborhood Hits	44
SwissProt Accessions	Q9EPU0, Q99PR4	Gene names	Upf1, Rent1
Domain Architecture
Description	Regulator of nonsense transcripts 1 (EC 3.6.1.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up- frameshift suppressor 1 homolog) (mUpf1).

SMBP2_HUMAN
NC score	0.816993 (rank : 3)	θ value	2.18568e-46 (rank : 5)
Query Neighborhood Hits	51	Target Neighborhood Hits	107	Shared Neighborhood Hits	15
SwissProt Accessions	P38935, Q00443, Q14177	Gene names	IGHMBP2, SMBP2, SMUBP2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Glial factor 1) (GF-1).

SMBP2_MOUSE
NC score	0.816595 (rank : 4)	θ value	1.15895e-47 (rank : 3)
Query Neighborhood Hits	51	Target Neighborhood Hits	104	Shared Neighborhood Hits	15
SwissProt Accessions	P40694	Gene names	Ighmbp2, Smbp-2, Smbp2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Cardiac transcription factor 1) (CATF1).

PR285_HUMAN
NC score	0.783493 (rank : 5)	θ value	2.18568e-46 (rank : 4)
Query Neighborhood Hits	51	Target Neighborhood Hits	63	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BYK8, Q3C2G2, Q4VXQ1, Q8TEF3, Q96ND3, Q9C094	Gene names	PRIC285, KIAA1769
Domain Architecture
Description	Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein (EC 3.6.1.-) (ATP-dependent helicase PRIC285) (PPAR-alpha- interacting complex protein 285) (PPAR-gamma DBD-interacting protein 1) (PDIP1).

MOV10_MOUSE
NC score	0.780021 (rank : 6)	θ value	5.21438e-40 (rank : 7)
Query Neighborhood Hits	51	Target Neighborhood Hits	39	Shared Neighborhood Hits	19
SwissProt Accessions	P23249, Q9DC64	Gene names	Mov10, Gb110
Domain Architecture
Description	Putative helicase MOV-10 (EC 3.6.1.-) (Moloney leukemia virus 10 protein).

MOV10_HUMAN
NC score	0.777065 (rank : 7)	θ value	2.86122e-38 (rank : 8)
Query Neighborhood Hits	51	Target Neighborhood Hits	46	Shared Neighborhood Hits	19
SwissProt Accessions	Q9HCE1, Q8TEF0, Q9BSY3, Q9BUJ9	Gene names	MOV10, KIAA1631
Domain Architecture
Description	Putative helicase MOV-10 (EC 3.6.1.-) (Moloney leukemia virus 10 protein).

M10L1_HUMAN
NC score	0.765880 (rank : 8)	θ value	8.32485e-38 (rank : 9)
Query Neighborhood Hits	51	Target Neighborhood Hits	36	Shared Neighborhood Hits	18
SwissProt Accessions	Q9BXT6, Q5TGD5, Q8NBD4, Q9NXW3, Q9UFB3, Q9UGX9	Gene names	MOV10L1
Domain Architecture
Description	Putative helicase Mov10l1 (EC 3.6.1.-) (Moloney leukemia virus 10-like protein 1) (MOV10-like 1).

M10L1_MOUSE
NC score	0.762172 (rank : 9)	θ value	2.42216e-37 (rank : 10)
Query Neighborhood Hits	51	Target Neighborhood Hits	59	Shared Neighborhood Hits	19
SwissProt Accessions	Q99MV5, Q7TPA9, Q8C3W0, Q924C2	Gene names	Mov10l1, Champ
Domain Architecture
Description	Putative helicase Mov10l1 (EC 3.6.1.-) (Moloney leukemia virus 10-like protein 1) (MOV10-like 1) (Cardiac helicase activated by MEF2 protein) (Cardiac-specific RNA helicase).

SETX_HUMAN
NC score	0.745540 (rank : 10)	θ value	2.95404e-43 (rank : 6)
Query Neighborhood Hits	51	Target Neighborhood Hits	368	Shared Neighborhood Hits	17
SwissProt Accessions	Q7Z333, O75120, Q3KQX4, Q68DW5, Q6AZD7, Q7Z3J6, Q8WX33, Q9H9D1, Q9NVP9	Gene names	SETX, ALS4, KIAA0625, SCAR1
Domain Architecture
Description	Probable helicase senataxin (EC 3.6.1.-) (SEN1 homolog).

HELZ_HUMAN
NC score	0.708934 (rank : 11)	θ value	5.59698e-26 (rank : 13)
Query Neighborhood Hits	51	Target Neighborhood Hits	198	Shared Neighborhood Hits	18
SwissProt Accessions	P42694	Gene names	HELZ, KIAA0054
Domain Architecture	No domain graphic available
Description	Probable helicase with zinc-finger domain (EC 3.6.1.-).

AQR_MOUSE
NC score	0.574432 (rank : 12)	θ value	2.97466e-19 (rank : 15)
Query Neighborhood Hits	51	Target Neighborhood Hits	62	Shared Neighborhood Hits	17
SwissProt Accessions	Q8CFQ3, P97871, Q3U9N1, Q3ULE8, Q80TX8	Gene names	Aqr, Kiaa0560
Domain Architecture	No domain graphic available
Description	Intron-binding protein aquarius.

AQR_HUMAN
NC score	0.570851 (rank : 13)	θ value	2.97466e-19 (rank : 14)
Query Neighborhood Hits	51	Target Neighborhood Hits	88	Shared Neighborhood Hits	17
SwissProt Accessions	O60306, Q2YDX9, Q6IRU8, Q6PIC8	Gene names	AQR, KIAA0560
Domain Architecture	No domain graphic available
Description	Intron-binding protein aquarius (Intron-binding protein of 160 kDa) (IBP160).

ZNFX1_MOUSE
NC score	0.569517 (rank : 14)	θ value	5.22648e-32 (rank : 11)
Query Neighborhood Hits	51	Target Neighborhood Hits	407	Shared Neighborhood Hits	17
SwissProt Accessions	Q8R151, Q3U016, Q3UD71, Q3UEZ0	Gene names	ZNFX1
Domain Architecture	No domain graphic available
Description	NFX1-type zinc finger-containing protein 1.

ZNFX1_HUMAN
NC score	0.567569 (rank : 15)	θ value	4.42448e-31 (rank : 12)
Query Neighborhood Hits	51	Target Neighborhood Hits	308	Shared Neighborhood Hits	16
SwissProt Accessions	Q9P2E3, Q9BQM7, Q9BQM8, Q9H8C1, Q9H9S2, Q9NUM1, Q9NWW1	Gene names	ZNFX1, KIAA1404
Domain Architecture	No domain graphic available
Description	NFX1-type zinc finger-containing protein 1.

CX048_HUMAN
NC score	0.199912 (rank : 16)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	51	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WUE5, Q9NWY8	Gene names	CXorf48
Domain Architecture	No domain graphic available
Description	Protein CXorf48 (Tumor antigen BJ-HCC-20).

SPR2D_MOUSE
NC score	0.085290 (rank : 17)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	51	Target Neighborhood Hits	61	Shared Neighborhood Hits	2
SwissProt Accessions	O70555	Gene names	Sprr2d
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2D.

SPR2F_HUMAN
NC score	0.083384 (rank : 18)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	51	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	Q96RM1	Gene names	SPRR2F
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2F (SPR-2F).

SPR2B_MOUSE
NC score	0.083161 (rank : 19)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	51	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	O70554, Q7TSB2	Gene names	Sprr2b
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2B.

SPR2G_MOUSE
NC score	0.082735 (rank : 20)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	51	Target Neighborhood Hits	53	Shared Neighborhood Hits	2
SwissProt Accessions	O70558	Gene names	Sprr2g
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2G.

SPR2E_HUMAN
NC score	0.077782 (rank : 21)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	51	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	P22531, Q96RM2	Gene names	SPRR2E
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2E (SPR-2E) (Small proline-rich protein II) (SPR-II).

SPR2H_MOUSE
NC score	0.073358 (rank : 22)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	51	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	O70559	Gene names	Sprr2h
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2H.

SPR2I_MOUSE
NC score	0.068423 (rank : 23)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	51	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	O70560	Gene names	Sprr2i
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2I.

RRP44_HUMAN
NC score	0.067740 (rank : 24)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	51	Target Neighborhood Hits	35	Shared Neighborhood Hits	1
SwissProt Accessions	Q9Y2L1, Q5W0P7, Q5W0P8, Q658Z7, Q7Z481, Q8WWI2, Q9UG36	Gene names	DIS3, KIAA1008, RRP44
Domain Architecture
Description	Exosome complex exonuclease RRP44 (EC 3.1.13.-) (Ribosomal RNA- processing protein 44) (DIS3 protein homolog).

SPR2E_MOUSE
NC score	0.065521 (rank : 25)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	51	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	O70556	Gene names	Sprr2e
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2E.

LCE2D_HUMAN
NC score	0.062447 (rank : 26)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	51	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	Q5TA82	Gene names	LCE2D, LEP12, SPRL1A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2D (Late envelope protein 12) (Small proline-rich-like epidermal differentiation complex protein 1A).

LCE5A_HUMAN
NC score	0.059181 (rank : 27)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	51	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	Q5TCM9	Gene names	LCE5A, LEP18, SPRL5A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 5A (Late envelope protein 18) (Small proline-rich-like epidermal differentiation complex protein 5A).

NFX1_HUMAN
NC score	0.058902 (rank : 28)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	51	Target Neighborhood Hits	405	Shared Neighborhood Hits	5
SwissProt Accessions	Q12986	Gene names	NFX1
Domain Architecture
Description	Transcriptional repressor NF-X1 (EC 6.3.2.-) (Nuclear transcription factor, X box-binding, 1).

LCE2C_HUMAN
NC score	0.057317 (rank : 29)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	51	Target Neighborhood Hits	53	Shared Neighborhood Hits	3
SwissProt Accessions	Q5TA81	Gene names	LCE2C, LEP11
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2C (Late envelope protein 11).

SPR2B_HUMAN
NC score	0.052085 (rank : 30)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	51	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	P35325, Q5T528	Gene names	SPRR2B
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2B (SPR-2B).

KRA98_HUMAN
NC score	0.051926 (rank : 31)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	51	Target Neighborhood Hits	185	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BYQ0	Gene names	KRTAP9-8, KAP9.8, KRTAP9.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-8 (Keratin-associated protein 9.8) (Ultrahigh sulfur keratin-associated protein 9.8).

LCE1D_HUMAN
NC score	0.050926 (rank : 32)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	51	Target Neighborhood Hits	44	Shared Neighborhood Hits	2
SwissProt Accessions	Q5T752	Gene names	LCE1D, LEP4
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1D (Late envelope protein 4).

KRA99_HUMAN
NC score	0.050486 (rank : 33)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	51	Target Neighborhood Hits	173	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BYP9	Gene names	KRTAP9-9, KAP9.9, KRTAP9.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-9 (Keratin-associated protein 9.9) (Ultrahigh sulfur keratin-associated protein 9.9).

SPR2F_MOUSE
NC score	0.050250 (rank : 34)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	51	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	O70557	Gene names	Sprr2f
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2F.

RFC4_MOUSE
NC score	0.049050 (rank : 35)	θ value	4.03905 (rank : 38)
Query Neighborhood Hits	51	Target Neighborhood Hits	65	Shared Neighborhood Hits	13
SwissProt Accessions	Q99J62	Gene names	Rfc4
Domain Architecture	No domain graphic available
Description	Replication factor C subunit 4.

DLG7_HUMAN
NC score	0.047965 (rank : 36)	θ value	0.813845 (rank : 22)
Query Neighborhood Hits	51	Target Neighborhood Hits	53	Shared Neighborhood Hits	3
SwissProt Accessions	Q15398, Q8NG58	Gene names	DLG7, KIAA0008
Domain Architecture
Description	Discs large homolog 7 (Hepatoma up-regulated protein) (HURP).

RFC4_HUMAN
NC score	0.047193 (rank : 37)	θ value	4.03905 (rank : 37)
Query Neighborhood Hits	51	Target Neighborhood Hits	64	Shared Neighborhood Hits	13
SwissProt Accessions	P35249, Q6FHX7	Gene names	RFC4
Domain Architecture
Description	Replication factor C subunit 4 (Replication factor C 37 kDa subunit) (RF-C 37 kDa subunit) (RFC37) (Activator 1 37 kDa subunit) (A1 37 kDa subunit).

PRS8_HUMAN
NC score	0.043742 (rank : 38)	θ value	0.125558 (rank : 17)
Query Neighborhood Hits	51	Target Neighborhood Hits	117	Shared Neighborhood Hits	12
SwissProt Accessions	P62195, O35051, O43208, P47210, P52915, P52916	Gene names	PSMC5, SUG1
Domain Architecture
Description	26S protease regulatory subunit 8 (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (p45/SUG) (Thyroid hormone receptor- interacting protein 1) (TRIP1).

PRS8_MOUSE
NC score	0.043742 (rank : 39)	θ value	0.125558 (rank : 18)
Query Neighborhood Hits	51	Target Neighborhood Hits	117	Shared Neighborhood Hits	12
SwissProt Accessions	P62196, O35051, P47210, P52915, P52916, Q3UL51, Q9CWN5	Gene names	Psmc5, Sug1
Domain Architecture
Description	26S protease regulatory subunit 8 (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (p45/SUG) (mSUG1).

CT012_MOUSE
NC score	0.040375 (rank : 40)	θ value	0.47712 (rank : 20)
Query Neighborhood Hits	51	Target Neighborhood Hits	229	Shared Neighborhood Hits	3
SwissProt Accessions	Q8C008, Q8C060	Gene names
Domain Architecture	No domain graphic available
Description	Protein C20orf12 homolog.

UT14B_MOUSE
NC score	0.037571 (rank : 41)	θ value	0.813845 (rank : 23)
Query Neighborhood Hits	51	Target Neighborhood Hits	226	Shared Neighborhood Hits	8
SwissProt Accessions	Q6EJB6, Q6EJB5, Q8BL60	Gene names	Utp14b, Jsd
Domain Architecture	No domain graphic available
Description	U3 small nucleolar RNA-associated protein 14 homolog B (Juvenile spermatogonial depletion protein).

CAC1B_HUMAN
NC score	0.033509 (rank : 42)	θ value	0.0961366 (rank : 16)
Query Neighborhood Hits	51	Target Neighborhood Hits	257	Shared Neighborhood Hits	5
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

PEX1_HUMAN
NC score	0.033155 (rank : 43)	θ value	1.38821 (rank : 26)
Query Neighborhood Hits	51	Target Neighborhood Hits	98	Shared Neighborhood Hits	14
SwissProt Accessions	O43933, Q96S71, Q96S72, Q96S73, Q99994	Gene names	PEX1
Domain Architecture
Description	Peroxisome biogenesis factor 1 (Peroxin-1) (Peroxisome biogenesis disorder protein 1).

NUBP1_MOUSE
NC score	0.030980 (rank : 44)	θ value	2.36792 (rank : 31)
Query Neighborhood Hits	51	Target Neighborhood Hits	10	Shared Neighborhood Hits	4
SwissProt Accessions	Q9R060	Gene names	Nubp1
Domain Architecture
Description	Nucleotide-binding protein 1 (NBP 1).

CAC1B_MOUSE
NC score	0.028271 (rank : 45)	θ value	0.279714 (rank : 19)
Query Neighborhood Hits	51	Target Neighborhood Hits	351	Shared Neighborhood Hits	4
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

GALE_MOUSE
NC score	0.027852 (rank : 46)	θ value	3.0926 (rank : 34)
Query Neighborhood Hits	51	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R059	Gene names	Gale
Domain Architecture
Description	UDP-glucose 4-epimerase (EC 5.1.3.2) (Galactowaldenase) (UDP-galactose 4-epimerase).

PRS4_HUMAN
NC score	0.025380 (rank : 47)	θ value	5.27518 (rank : 41)
Query Neighborhood Hits	51	Target Neighborhood Hits	84	Shared Neighborhood Hits	9
SwissProt Accessions	P62191, P49014, Q03527, Q6IAW0, Q96AZ3	Gene names	PSMC1
Domain Architecture
Description	26S protease regulatory subunit 4 (P26s4) (Proteasome 26S subunit ATPase 1).

PRS4_MOUSE
NC score	0.025380 (rank : 48)	θ value	5.27518 (rank : 42)
Query Neighborhood Hits	51	Target Neighborhood Hits	84	Shared Neighborhood Hits	9
SwissProt Accessions	P62192, P49014, Q03527, Q96AZ3	Gene names	Psmc1
Domain Architecture
Description	26S protease regulatory subunit 4 (P26s4) (Proteasome 26S subunit ATPase 1).

KIFA3_HUMAN
NC score	0.024417 (rank : 49)	θ value	1.38821 (rank : 25)
Query Neighborhood Hits	51	Target Neighborhood Hits	29	Shared Neighborhood Hits	2
SwissProt Accessions	Q92845, Q8NHU7, Q9H416	Gene names	KIFAP3, SMAP
Domain Architecture
Description	Kinesin-associated protein 3 (Smg GDS-associated protein).

PRS6A_MOUSE
NC score	0.023447 (rank : 50)	θ value	8.99809 (rank : 49)
Query Neighborhood Hits	51	Target Neighborhood Hits	85	Shared Neighborhood Hits	11
SwissProt Accessions	O88685	Gene names	Psmc3, Tbp1
Domain Architecture
Description	26S protease regulatory subunit 6A (Proteasome 26S subunit ATPase 3) (TAT-binding protein 1) (TBP-1).

PRS6A_HUMAN
NC score	0.023430 (rank : 51)	θ value	8.99809 (rank : 48)
Query Neighborhood Hits	51	Target Neighborhood Hits	87	Shared Neighborhood Hits	11
SwissProt Accessions	P17980, Q96HD3	Gene names	PSMC3, TBP1
Domain Architecture
Description	26S protease regulatory subunit 6A (Proteasome 26S subunit ATPase 3) (TAT-binding protein 1) (TBP-1) (Proteasome subunit P50).

CN115_HUMAN
NC score	0.023153 (rank : 52)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	51	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H8Y1, Q9NVC7	Gene names	C14orf115
Domain Architecture
Description	Uncharacterized protein C14orf115.

NUBP1_HUMAN
NC score	0.022300 (rank : 53)	θ value	6.88961 (rank : 45)
Query Neighborhood Hits	51	Target Neighborhood Hits	16	Shared Neighborhood Hits	4
SwissProt Accessions	P53384	Gene names	NUBP1, NBP, NBP1
Domain Architecture
Description	Nucleotide-binding protein 1 (NBP 1).

MLL3_HUMAN
NC score	0.021939 (rank : 54)	θ value	0.62314 (rank : 21)
Query Neighborhood Hits	51	Target Neighborhood Hits	1644	Shared Neighborhood Hits	12
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

DAB2_MOUSE
NC score	0.019834 (rank : 55)	θ value	5.27518 (rank : 39)
Query Neighborhood Hits	51	Target Neighborhood Hits	163	Shared Neighborhood Hits	5
SwissProt Accessions	P98078, Q3U3K1, Q91W56, Q923E1	Gene names	Dab2, Doc2
Domain Architecture
Description	Disabled homolog 2 (DOC-2) (Mitogen-responsive phosphoprotein).

BIG1_HUMAN
NC score	0.019741 (rank : 56)	θ value	1.81305 (rank : 27)
Query Neighborhood Hits	51	Target Neighborhood Hits	76	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Y6D6, Q9NV46, Q9UFV2, Q9UNL0	Gene names	ARFGEF1, ARFGEP1, BIG1
Domain Architecture
Description	Brefeldin A-inhibited guanine nucleotide-exchange protein 1 (Brefeldin A-inhibited GEP 1) (p200 ARF-GEP1) (p200 ARF guanine nucleotide exchange factor).

CLAP2_HUMAN
NC score	0.017900 (rank : 57)	θ value	1.81305 (rank : 28)
Query Neighborhood Hits	51	Target Neighborhood Hits	85	Shared Neighborhood Hits	4
SwissProt Accessions	O75122, Q7L8F6, Q8N6R6, Q9BQT3, Q9BQT4, Q9H7A3, Q9NSZ2	Gene names	CLASP2, KIAA0627
Domain Architecture	No domain graphic available
Description	CLIP-associating protein 2 (Cytoplasmic linker-associated protein 2).

MTMR3_HUMAN
NC score	0.016170 (rank : 58)	θ value	1.81305 (rank : 29)
Query Neighborhood Hits	51	Target Neighborhood Hits	163	Shared Neighborhood Hits	3
SwissProt Accessions	Q13615, Q9NYN5, Q9NYN6, Q9UDX6, Q9UEG3	Gene names	MTMR3, KIAA0371, ZFYVE10
Domain Architecture
Description	Myotubularin-related protein 3 (EC 3.1.3.48) (FYVE domain-containing dual specificity protein phosphatase 1) (FYVE-DSP1) (Zinc finger FYVE domain-containing protein 10).

PO121_MOUSE
NC score	0.013068 (rank : 59)	θ value	4.03905 (rank : 36)
Query Neighborhood Hits	51	Target Neighborhood Hits	345	Shared Neighborhood Hits	5
SwissProt Accessions	Q8K3Z9, Q7TSH5	Gene names	Pom121, Nup121
Domain Architecture	No domain graphic available
Description	Nuclear envelope pore membrane protein POM 121 (Pore membrane protein of 121 kDa).

CHD4_HUMAN
NC score	0.012737 (rank : 60)	θ value	3.0926 (rank : 32)
Query Neighborhood Hits	51	Target Neighborhood Hits	365	Shared Neighborhood Hits	5
SwissProt Accessions	Q14839, Q8IXZ5	Gene names	CHD4
Domain Architecture
Description	Chromodomain helicase-DNA-binding protein 4 (EC 3.6.1.-) (ATP- dependent helicase CHD4) (CHD-4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta).

CHD4_MOUSE
NC score	0.012580 (rank : 61)	θ value	3.0926 (rank : 33)
Query Neighborhood Hits	51	Target Neighborhood Hits	408	Shared Neighborhood Hits	5
SwissProt Accessions	Q6PDQ2	Gene names	Chd4
Domain Architecture	No domain graphic available
Description	Chromodomain helicase-DNA-binding protein 4 (CHD-4).

MDC1_MOUSE
NC score	0.009679 (rank : 62)	θ value	8.99809 (rank : 47)
Query Neighborhood Hits	51	Target Neighborhood Hits	998	Shared Neighborhood Hits	9
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

FREM3_HUMAN
NC score	0.008109 (rank : 63)	θ value	4.03905 (rank : 35)
Query Neighborhood Hits	51	Target Neighborhood Hits	56	Shared Neighborhood Hits	2
SwissProt Accessions	P0C091	Gene names	FREM3
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 3 precursor.

MY18B_HUMAN
NC score	0.007498 (rank : 64)	θ value	2.36792 (rank : 30)
Query Neighborhood Hits	51	Target Neighborhood Hits	1299	Shared Neighborhood Hits	7
SwissProt Accessions	Q8IUG5, Q8NDI8, Q8TE65, Q8WWS0, Q96KH2, Q96KR8, Q96KR9	Gene names	MYO18B
Domain Architecture
Description	Myosin-18B (Myosin XVIIIb).

CO4A2_MOUSE
NC score	0.006990 (rank : 65)	θ value	1.38821 (rank : 24)
Query Neighborhood Hits	51	Target Neighborhood Hits	492	Shared Neighborhood Hits	5
SwissProt Accessions	P08122, Q61375	Gene names	Col4a2
Domain Architecture
Description	Collagen alpha-2(IV) chain precursor.

RALB_MOUSE
NC score	0.004158 (rank : 66)	θ value	5.27518 (rank : 43)
Query Neighborhood Hits	51	Target Neighborhood Hits	274	Shared Neighborhood Hits	5
SwissProt Accessions	Q9JIW9, Q3TVS5	Gene names	Ralb
Domain Architecture
Description	Ras-related protein Ral-B.

MYO5A_HUMAN
NC score	0.003761 (rank : 67)	θ value	5.27518 (rank : 40)
Query Neighborhood Hits	51	Target Neighborhood Hits	1092	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y4I1, O60653, Q07902, Q16249, Q9UE30, Q9UE31	Gene names	MYO5A, MYH12
Domain Architecture
Description	Myosin-5A (Myosin Va) (Dilute myosin heavy chain, non-muscle) (Myosin heavy chain 12) (Myoxin).

HOOK3_HUMAN
NC score	0.003567 (rank : 68)	θ value	6.88961 (rank : 44)
Query Neighborhood Hits	51	Target Neighborhood Hits	1070	Shared Neighborhood Hits	7
SwissProt Accessions	Q86VS8, Q8NBH0, Q9BY13	Gene names	HOOK3
Domain Architecture
Description	Hook homolog 3 (hHK3).

RAB21_HUMAN
NC score	0.001600 (rank : 69)	θ value	8.99809 (rank : 50)
Query Neighborhood Hits	51	Target Neighborhood Hits	270	Shared Neighborhood Hits	4
SwissProt Accessions	Q9UL25, Q14466	Gene names	RAB21, KIAA0118
Domain Architecture
Description	Ras-related protein Rab-21.

RAB21_MOUSE
NC score	0.001581 (rank : 70)	θ value	8.99809 (rank : 51)
Query Neighborhood Hits	51	Target Neighborhood Hits	268	Shared Neighborhood Hits	4
SwissProt Accessions	P35282, Q7TPN7	Gene names	Rab21
Domain Architecture
Description	Ras-related protein Rab-21 (Rab-12).