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Network neighborhood for query Sequence : FREM3_HUMAN

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FREM3_HUMAN
SwissProt Accessions	P0C091	Gene names	FREM3
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 3 precursor.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

FREM1_HUMAN
θ value	0 (rank : 1)	NC score	0.871556 (rank : 5)
Query Neighborhood Hits	56	Target Neighborhood Hits	170	Shared Neighborhood Hits	19
SwissProt Accessions	Q5H8C1, Q5VV00, Q5VV01, Q6MZI4, Q8NEG9, Q96LI3	Gene names	FREM1, C9orf154
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 1 precursor (Protein QBRICK).

FREM1_MOUSE
θ value	0 (rank : 2)	NC score	0.858746 (rank : 6)
Query Neighborhood Hits	56	Target Neighborhood Hits	163	Shared Neighborhood Hits	20
SwissProt Accessions	Q684R7, Q5H8C2, Q5M7B3, Q8C732	Gene names	Frem1
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 1 precursor (Protein QBRICK).

FREM2_HUMAN
θ value	0 (rank : 3)	NC score	0.987862 (rank : 3)
Query Neighborhood Hits	56	Target Neighborhood Hits	76	Shared Neighborhood Hits	25
SwissProt Accessions	Q5SZK8, Q4QQG1, Q5H9N8, Q5T6Q1, Q6N057, Q6ZSB4, Q7Z305, Q7Z341	Gene names	FREM2
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 2 precursor (ECM3 homolog).

FREM2_MOUSE
θ value	0 (rank : 4)	NC score	0.986497 (rank : 4)
Query Neighborhood Hits	56	Target Neighborhood Hits	73	Shared Neighborhood Hits	23
SwissProt Accessions	Q6NVD0, Q4W2Q5, Q5H8C0, Q811G9, Q8C4G5, Q8CD46	Gene names	Frem2, Nv1
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 2 precursor (ECM3 homolog) (NV domain-containing protein 1).

FREM3_HUMAN
θ value	0 (rank : 5)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	56	Target Neighborhood Hits	56	Shared Neighborhood Hits	56
SwissProt Accessions	P0C091	Gene names	FREM3
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 3 precursor.

FREM3_MOUSE
θ value	0 (rank : 6)	NC score	0.994776 (rank : 2)
Query Neighborhood Hits	56	Target Neighborhood Hits	49	Shared Neighborhood Hits	22
SwissProt Accessions	Q5H8B9	Gene names	Frem3, Nv2
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 3 precursor (NV domain- containing protein 2).

FRAS1_HUMAN
θ value	1.0077e-184 (rank : 7)	NC score	0.644857 (rank : 9)
Query Neighborhood Hits	56	Target Neighborhood Hits	759	Shared Neighborhood Hits	22
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

FRAS1_MOUSE
θ value	5.01279e-176 (rank : 8)	NC score	0.638296 (rank : 10)
Query Neighborhood Hits	56	Target Neighborhood Hits	747	Shared Neighborhood Hits	19
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

CSPG4_HUMAN
θ value	1.72781e-51 (rank : 9)	NC score	0.721350 (rank : 7)
Query Neighborhood Hits	56	Target Neighborhood Hits	112	Shared Neighborhood Hits	13
SwissProt Accessions	Q6UVK1, Q92675	Gene names	CSPG4, MCSP
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 4 precursor (Chondroitin sulfate proteoglycan NG2) (Melanoma chondroitin sulfate proteoglycan) (Melanoma-associated chondroitin sulfate proteoglycan).

CSPG4_MOUSE
θ value	1.72781e-51 (rank : 10)	NC score	0.709507 (rank : 8)
Query Neighborhood Hits	56	Target Neighborhood Hits	105	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VHY0, Q5DTG1, Q8BPI8, Q8CE79	Gene names	Cspg4, An2, Kiaa4232, Ng2
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 4 precursor (Chondroitin sulfate proteoglycan NG2) (AN2 proteoglycan).

NAC1_MOUSE
θ value	2.98157e-11 (rank : 11)	NC score	0.380023 (rank : 12)
Query Neighborhood Hits	56	Target Neighborhood Hits	41	Shared Neighborhood Hits	15
SwissProt Accessions	P70414	Gene names	Slc8a1, Ncx
Domain Architecture
Description	Sodium/calcium exchanger 1 precursor (Na(+)/Ca(2+)-exchange protein 1).

NAC1_HUMAN
θ value	8.67504e-11 (rank : 12)	NC score	0.386870 (rank : 11)
Query Neighborhood Hits	56	Target Neighborhood Hits	43	Shared Neighborhood Hits	15
SwissProt Accessions	P32418, O95849, Q9UBL8, Q9UDN1, Q9UDN2, Q9UKX6	Gene names	SLC8A1, CNC, NCX1
Domain Architecture
Description	Sodium/calcium exchanger 1 precursor (Na(+)/Ca(2+)-exchange protein 1).

GPR98_MOUSE
θ value	7.34386e-10 (rank : 13)	NC score	0.301539 (rank : 15)
Query Neighborhood Hits	56	Target Neighborhood Hits	206	Shared Neighborhood Hits	19
SwissProt Accessions	Q8VHN7, Q6ZQ69, Q810D2, Q810D3, Q91ZS0, Q91ZS1	Gene names	Gpr98, Kiaa0686, Mass1, Vlgr1
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor 98 precursor (Monogenic audiogenic seizure susceptibility protein 1) (Very large G-protein coupled receptor 1) (Neurepin).

NAC3_HUMAN
θ value	1.63604e-09 (rank : 14)	NC score	0.369406 (rank : 13)
Query Neighborhood Hits	56	Target Neighborhood Hits	42	Shared Neighborhood Hits	15
SwissProt Accessions	P57103, Q8IUE9, Q8IUF0, Q8NFI7	Gene names	SLC8A3, NCX3
Domain Architecture
Description	Sodium/calcium exchanger 3 precursor (Na(+)/Ca(2+)-exchange protein 3).

NAC2_HUMAN
θ value	4.0297e-08 (rank : 15)	NC score	0.342188 (rank : 14)
Query Neighborhood Hits	56	Target Neighborhood Hits	33	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UPR5	Gene names	SLC8A2, KIAA1087, NCX2
Domain Architecture
Description	Sodium/calcium exchanger 2 precursor (Na(+)/Ca(2+)-exchange protein 2).

GPR98_HUMAN
θ value	2.21117e-06 (rank : 16)	NC score	0.288885 (rank : 16)
Query Neighborhood Hits	56	Target Neighborhood Hits	202	Shared Neighborhood Hits	18
SwissProt Accessions	Q8WXG9, O75171, Q9H0X5, Q9UL61	Gene names	GPR98, KIAA0686, MASS1, VLGR1
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor 98 precursor (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Very large G-protein coupled receptor 1) (Usher syndrome type-2C protein).

ITB4_HUMAN
θ value	0.000158464 (rank : 17)	NC score	0.092849 (rank : 17)
Query Neighborhood Hits	56	Target Neighborhood Hits	458	Shared Neighborhood Hits	21
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

PCD15_HUMAN
θ value	0.0252991 (rank : 18)	NC score	0.027909 (rank : 65)
Query Neighborhood Hits	56	Target Neighborhood Hits	289	Shared Neighborhood Hits	14
SwissProt Accessions	Q96QU1, Q96QT8	Gene names	PCDH15
Domain Architecture
Description	Protocadherin-15 precursor.

RSMN_HUMAN
θ value	0.125558 (rank : 19)	NC score	0.045298 (rank : 58)
Query Neighborhood Hits	56	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	P63162, P14648, P17135	Gene names	SNRPN, HCERN3, SMN
Domain Architecture	No domain graphic available
Description	Small nuclear ribonucleoprotein-associated protein N (snRNP-N) (Sm protein N) (Sm-N) (SmN) (Sm-D) (Tissue-specific-splicing protein).

RSMN_MOUSE
θ value	0.125558 (rank : 20)	NC score	0.045298 (rank : 59)
Query Neighborhood Hits	56	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	P63163, P14648, P17135	Gene names	Snrpn, Smn
Domain Architecture	No domain graphic available
Description	Small nuclear ribonucleoprotein-associated protein N (snRNP-N) (Sm protein N) (Sm-N) (SmN) (Sm-D) (Tissue-specific-splicing protein).

FAT2_HUMAN
θ value	0.21417 (rank : 21)	NC score	0.033212 (rank : 60)
Query Neighborhood Hits	56	Target Neighborhood Hits	507	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NYQ8, O75091, Q9NSR7	Gene names	FAT2, CDHF8, KIAA0811, MEGF1
Domain Architecture
Description	Protocadherin Fat 2 precursor (hFat2) (Multiple epidermal growth factor-like domains 1).

PCDG3_HUMAN
θ value	0.279714 (rank : 22)	NC score	0.015327 (rank : 72)
Query Neighborhood Hits	56	Target Neighborhood Hits	155	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y5H0, Q9Y5D4	Gene names	PCDHGA3
Domain Architecture
Description	Protocadherin gamma A3 precursor (PCDH-gamma-A3).

PCDGA_HUMAN
θ value	0.365318 (rank : 23)	NC score	0.015438 (rank : 71)
Query Neighborhood Hits	56	Target Neighborhood Hits	160	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y5H3, Q9Y5E0	Gene names	PCDHGA10
Domain Architecture
Description	Protocadherin gamma A10 precursor (PCDH-gamma-A10).

SPB6_HUMAN
θ value	0.62314 (rank : 24)	NC score	0.005963 (rank : 89)
Query Neighborhood Hits	56	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	P35237, Q96J44	Gene names	SERPINB6, PI6, PTI
Domain Architecture
Description	Serpin B6 (Placental thrombin inhibitor) (Cytoplasmic antiproteinase) (CAP) (Protease inhibitor 6) (PI-6).

P4HA2_HUMAN
θ value	1.06291 (rank : 25)	NC score	0.015851 (rank : 70)
Query Neighborhood Hits	56	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	O15460, Q8WWN0	Gene names	P4HA2
Domain Architecture
Description	Prolyl 4-hydroxylase alpha-2 subunit precursor (EC 1.14.11.2) (4-PH alpha-2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase alpha-2 subunit).

PCDH9_HUMAN
θ value	1.06291 (rank : 26)	NC score	0.023630 (rank : 66)
Query Neighborhood Hits	56	Target Neighborhood Hits	180	Shared Neighborhood Hits	15
SwissProt Accessions	Q9HC56	Gene names	PCDH9
Domain Architecture
Description	Protocadherin-9 precursor.

DSC1_HUMAN
θ value	1.38821 (rank : 27)	NC score	0.011208 (rank : 74)
Query Neighborhood Hits	56	Target Neighborhood Hits	154	Shared Neighborhood Hits	12
SwissProt Accessions	Q08554	Gene names	DSC1
Domain Architecture
Description	Desmocollin-1 precursor (Desmosomal glycoprotein 2/3) (DG2/DG3).

PTPRM_HUMAN
θ value	1.81305 (rank : 28)	NC score	0.009999 (rank : 75)
Query Neighborhood Hits	56	Target Neighborhood Hits	244	Shared Neighborhood Hits	7
SwissProt Accessions	P28827	Gene names	PTPRM, PTPRL1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

SYT1_HUMAN
θ value	1.81305 (rank : 29)	NC score	0.009188 (rank : 79)
Query Neighborhood Hits	56	Target Neighborhood Hits	150	Shared Neighborhood Hits	6
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
θ value	1.81305 (rank : 30)	NC score	0.009128 (rank : 80)
Query Neighborhood Hits	56	Target Neighborhood Hits	150	Shared Neighborhood Hits	5
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

ZNF38_HUMAN
θ value	1.81305 (rank : 31)	NC score	-0.001422 (rank : 96)
Query Neighborhood Hits	56	Target Neighborhood Hits	742	Shared Neighborhood Hits	3
SwissProt Accessions	P17036, P13683, Q9NNX8, Q9NXJ1, Q9UC15, Q9UC16	Gene names	ZNF38, KOX25, ZNF3
Domain Architecture
Description	Zinc finger protein 38 (Zinc finger protein KOX25) (Zinc finger protein HF.12) (Zinc finger protein 3) (HZF3.1).

PTPRM_MOUSE
θ value	2.36792 (rank : 32)	NC score	0.009818 (rank : 76)
Query Neighborhood Hits	56	Target Neighborhood Hits	238	Shared Neighborhood Hits	7
SwissProt Accessions	P28828	Gene names	Ptprm
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PCDH1_HUMAN
θ value	3.0926 (rank : 33)	NC score	0.012460 (rank : 73)
Query Neighborhood Hits	56	Target Neighborhood Hits	174	Shared Neighborhood Hits	11
SwissProt Accessions	Q08174	Gene names	PCDH1
Domain Architecture
Description	Protocadherin-1 precursor (Protocadherin-42) (PC42) (Cadherin-like protein 1).

MMP25_HUMAN
θ value	4.03905 (rank : 34)	NC score	0.003954 (rank : 92)
Query Neighborhood Hits	56	Target Neighborhood Hits	56	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NPA2, Q9H3Q0	Gene names	MMP25, MT6MMP
Domain Architecture
Description	Matrix metalloproteinase-25 precursor (EC 3.4.24.-) (MMP-25) (Membrane-type matrix metalloproteinase 6) (MT-MMP 6) (Membrane-type-6 matrix metalloproteinase) (MT6-MMP) (Leukolysin).

OPLA_HUMAN
θ value	4.03905 (rank : 35)	NC score	0.023117 (rank : 68)
Query Neighborhood Hits	56	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	O14841, Q75W65, Q9Y4Q0	Gene names	OPLAH
Domain Architecture	No domain graphic available
Description	5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (Pyroglutamase) (5- OPase).

OPLA_MOUSE
θ value	4.03905 (rank : 36)	NC score	0.023172 (rank : 67)
Query Neighborhood Hits	56	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K010, Q8R3K2	Gene names	Oplah
Domain Architecture
Description	5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (Pyroglutamase) (5- OPase).

RENT1_HUMAN
θ value	4.03905 (rank : 37)	NC score	0.008109 (rank : 82)
Query Neighborhood Hits	56	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	Q92900, O00239, O43343, Q86Z25, Q92842	Gene names	UPF1, KIAA0221, RENT1
Domain Architecture
Description	Regulator of nonsense transcripts 1 (EC 3.6.1.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up- frameshift suppressor 1 homolog) (hUpf1).

STAR8_HUMAN
θ value	4.03905 (rank : 38)	NC score	0.005893 (rank : 90)
Query Neighborhood Hits	56	Target Neighborhood Hits	216	Shared Neighborhood Hits	2
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

OTU7A_HUMAN
θ value	5.27518 (rank : 39)	NC score	0.008070 (rank : 83)
Query Neighborhood Hits	56	Target Neighborhood Hits	74	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TE49, Q8IWK5	Gene names	OTUD7A, C15orf16, OTUD7
Domain Architecture	No domain graphic available
Description	OTU domain-containing protein 7A (EC 3.-.-.-) (Zinc finger protein Cezanne 2).

PTPRK_HUMAN
θ value	5.27518 (rank : 40)	NC score	0.009345 (rank : 78)
Query Neighborhood Hits	56	Target Neighborhood Hits	228	Shared Neighborhood Hits	6
SwissProt Accessions	Q15262, Q14763	Gene names	PTPRK, PTPK
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRK_MOUSE
θ value	5.27518 (rank : 41)	NC score	0.009428 (rank : 77)
Query Neighborhood Hits	56	Target Neighborhood Hits	223	Shared Neighborhood Hits	6
SwissProt Accessions	P35822	Gene names	Ptprk, Ptpk
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

RSMB_MOUSE
θ value	5.27518 (rank : 42)	NC score	0.031192 (rank : 62)
Query Neighborhood Hits	56	Target Neighborhood Hits	93	Shared Neighborhood Hits	5
SwissProt Accessions	P27048, Q3UJT1	Gene names	Snrpb
Domain Architecture
Description	Small nuclear ribonucleoprotein-associated protein B (snRNP-B) (Sm protein B) (Sm-B) (SmB).

TRPC6_HUMAN
θ value	5.27518 (rank : 43)	NC score	0.006453 (rank : 88)
Query Neighborhood Hits	56	Target Neighborhood Hits	171	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y210, Q9HCW3, Q9NQA8, Q9NQA9	Gene names	TRPC6, TRP6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6).

TRPC6_MOUSE
θ value	5.27518 (rank : 44)	NC score	0.006549 (rank : 87)
Query Neighborhood Hits	56	Target Neighborhood Hits	171	Shared Neighborhood Hits	3
SwissProt Accessions	Q61143, Q9Z2J1	Gene names	Trpc6, Trp6, Trrp6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6) (Calcium entry channel).

AAK1_MOUSE
θ value	6.88961 (rank : 45)	NC score	-0.000271 (rank : 94)
Query Neighborhood Hits	56	Target Neighborhood Hits	1051	Shared Neighborhood Hits	3
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

CAD23_MOUSE
θ value	6.88961 (rank : 46)	NC score	0.029639 (rank : 63)
Query Neighborhood Hits	56	Target Neighborhood Hits	208	Shared Neighborhood Hits	20
SwissProt Accessions	Q99PF4, Q99NH1, Q9D4N9	Gene names	Cdh23
Domain Architecture
Description	Cadherin-23 precursor (Otocadherin).

PCD16_HUMAN
θ value	6.88961 (rank : 47)	NC score	0.022315 (rank : 69)
Query Neighborhood Hits	56	Target Neighborhood Hits	245	Shared Neighborhood Hits	19
SwissProt Accessions	Q96JQ0, O15098	Gene names	DCHS1, CDH19, FIB1, KIAA1773, PCDH16
Domain Architecture
Description	Protocadherin-16 precursor (Dachsous 1) (Cadherin-19) (Fibroblast cadherin 1).

CO7A1_HUMAN
θ value	8.99809 (rank : 48)	NC score	0.000594 (rank : 93)
Query Neighborhood Hits	56	Target Neighborhood Hits	807	Shared Neighborhood Hits	6
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

GPR87_HUMAN
θ value	8.99809 (rank : 49)	NC score	-0.001064 (rank : 95)
Query Neighborhood Hits	56	Target Neighborhood Hits	591	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BY21, Q96JZ8, Q9BXC2	Gene names	GPR87, GPR95
Domain Architecture
Description	Probable G-protein coupled receptor 87 (G-protein coupled receptor 95).

IGF2_HUMAN
θ value	8.99809 (rank : 50)	NC score	0.008489 (rank : 81)
Query Neighborhood Hits	56	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P01344, P78449, Q14299, Q9UC68, Q9UC69	Gene names	IGF2
Domain Architecture
Description	Insulin-like growth factor II precursor (IGF-II) (Somatomedin A) [Contains: Insulin-like growth factor II Ala-25 Del].

MEF2A_HUMAN
θ value	8.99809 (rank : 51)	NC score	0.005061 (rank : 91)
Query Neighborhood Hits	56	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	Q02078, O43814, Q14223, Q14224, Q96D14	Gene names	MEF2A, MEF2
Domain Architecture
Description	Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1).

RSMB_HUMAN
θ value	8.99809 (rank : 52)	NC score	0.028330 (rank : 64)
Query Neighborhood Hits	56	Target Neighborhood Hits	117	Shared Neighborhood Hits	5
SwissProt Accessions	P14678, Q15490, Q9UIS5	Gene names	SNRPB, COD, SNRPB1
Domain Architecture
Description	Small nuclear ribonucleoprotein-associated proteins B and B' (snRNP-B) (Sm protein B/B') (Sm-B/Sm-B') (SmB/SmB').

SYT2_HUMAN
θ value	8.99809 (rank : 53)	NC score	0.006698 (rank : 85)
Query Neighborhood Hits	56	Target Neighborhood Hits	142	Shared Neighborhood Hits	5
SwissProt Accessions	Q8N9I0, Q496K5, Q8NBE5	Gene names	SYT2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT2_MOUSE
θ value	8.99809 (rank : 54)	NC score	0.006678 (rank : 86)
Query Neighborhood Hits	56	Target Neighborhood Hits	143	Shared Neighborhood Hits	5
SwissProt Accessions	P46097, Q8R0E1	Gene names	Syt2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

TNR16_MOUSE
θ value	8.99809 (rank : 55)	NC score	0.032384 (rank : 61)
Query Neighborhood Hits	56	Target Neighborhood Hits	178	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z0W1	Gene names	Ngfr, Tnfrsf16
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 16 precursor (Low- affinity nerve growth factor receptor) (NGF receptor) (Low affinity neurotrophin receptor p75NTR).

ZN346_MOUSE
θ value	8.99809 (rank : 56)	NC score	0.007489 (rank : 84)
Query Neighborhood Hits	56	Target Neighborhood Hits	93	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R0B7	Gene names	Znf346, Jaz, Zfp346
Domain Architecture	No domain graphic available
Description	Zinc finger protein 346 (Just another zinc finger protein).

BMPER_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.090420 (rank : 18)
Query Neighborhood Hits	56	Target Neighborhood Hits	175	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N8U9	Gene names	BMPER
Domain Architecture
Description	BMP-binding endothelial regulator protein precursor (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (hCV2).

BMPER_MOUSE
θ value	θ > 10 (rank : 58)	NC score	0.085016 (rank : 21)
Query Neighborhood Hits	56	Target Neighborhood Hits	194	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CJ69, Q7TN57, Q80UZ1, Q9CXM8	Gene names	Bmper, Cv2
Domain Architecture
Description	BMP-binding endothelial regulator protein precursor (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (mCV2).

CHRD_HUMAN
θ value	θ > 10 (rank : 59)	NC score	0.090382 (rank : 19)
Query Neighborhood Hits	56	Target Neighborhood Hits	102	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H2X0, O95254, Q6UW83, Q9H2D3, Q9H2W8, Q9H2W9, Q9P0Z2, Q9P0Z3, Q9P0Z4, Q9P0Z5	Gene names	CHRD
Domain Architecture
Description	Chordin precursor.

CHRD_MOUSE
θ value	θ > 10 (rank : 60)	NC score	0.086009 (rank : 20)
Query Neighborhood Hits	56	Target Neighborhood Hits	102	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z0E2	Gene names	Chrd
Domain Architecture
Description	Chordin precursor.

CRDL1_HUMAN
θ value	θ > 10 (rank : 61)	NC score	0.071269 (rank : 28)
Query Neighborhood Hits	56	Target Neighborhood Hits	75	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BU40, Q9Y3H7	Gene names	CHRDL1, NRLN1
Domain Architecture
Description	Chordin-like protein 1 precursor (Neuralin-1) (Ventroptin) (Neurogenesin-1).

CRDL1_MOUSE
θ value	θ > 10 (rank : 62)	NC score	0.064569 (rank : 34)
Query Neighborhood Hits	56	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	Q920C1, Q924K0, Q9EPZ9	Gene names	Chrdl1, Ng1, Nrln1
Domain Architecture
Description	Chordin-like protein 1 precursor (Neuralin-1) (Ventroptin) (Neurogenesin-1).

CRDL2_HUMAN
θ value	θ > 10 (rank : 63)	NC score	0.071260 (rank : 29)
Query Neighborhood Hits	56	Target Neighborhood Hits	99	Shared Neighborhood Hits	2
SwissProt Accessions	Q6WN34, Q6WN30, Q6WN31, Q6WN32, Q7Z5J3	Gene names	CHRDL2, BNF1, CHL2
Domain Architecture	No domain graphic available
Description	Chordin-like protein 2 precursor (Chordin-related protein 2) (Breast tumor novel factor 1) (BNF-1).

CRDL2_MOUSE
θ value	θ > 10 (rank : 64)	NC score	0.066770 (rank : 31)
Query Neighborhood Hits	56	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VEA6, Q925I3	Gene names	Chrdl2, Chl2
Domain Architecture	No domain graphic available
Description	Chordin-like protein 2 precursor.

CRIM1_HUMAN
θ value	θ > 10 (rank : 65)	NC score	0.084697 (rank : 22)
Query Neighborhood Hits	56	Target Neighborhood Hits	362	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

KR101_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.057930 (rank : 43)
Query Neighborhood Hits	56	Target Neighborhood Hits	261	Shared Neighborhood Hits	2
SwissProt Accessions	P60331	Gene names	KRTAP10-1, KAP10.1, KAP18-1, KRTAP10.1, KRTAP18-1, KRTAP18.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-1 (Keratin-associated protein 10.1) (High sulfur keratin-associated protein 10.1) (Keratin-associated protein 18-1) (Keratin-associated protein 18.1).

KR104_HUMAN
θ value	θ > 10 (rank : 67)	NC score	0.061774 (rank : 38)
Query Neighborhood Hits	56	Target Neighborhood Hits	313	Shared Neighborhood Hits	2
SwissProt Accessions	P60372	Gene names	KRTAP10-4, KAP10.4, KAP18-4, KRTAP10.4, KRTAP18-4, KRTAP18.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-4 (Keratin-associated protein 10.4) (High sulfur keratin-associated protein 10.4) (Keratin-associated protein 18-4) (Keratin-associated protein 18.4).

KR105_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.052113 (rank : 50)
Query Neighborhood Hits	56	Target Neighborhood Hits	271	Shared Neighborhood Hits	2
SwissProt Accessions	P60370, Q70LJ3	Gene names	KRTAP10-5, KAP10.5, KAP18-5, KRTAP10.5, KRTAP18-5, KRTAP18.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-5 (Keratin-associated protein 10.5) (High sulfur keratin-associated protein 10.5) (Keratin-associated protein 18-5) (Keratin-associated protein 18.5).

KR107_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.058260 (rank : 42)
Query Neighborhood Hits	56	Target Neighborhood Hits	330	Shared Neighborhood Hits	2
SwissProt Accessions	P60409, Q70LJ2	Gene names	KRTAP10-7, KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-7 (Keratin-associated protein 10.7) (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7).

KR108_HUMAN
θ value	θ > 10 (rank : 70)	NC score	0.065839 (rank : 32)
Query Neighborhood Hits	56	Target Neighborhood Hits	226	Shared Neighborhood Hits	2
SwissProt Accessions	P60410	Gene names	KRTAP10-8, KAP10.8, KAP18-8, KRTAP10.8, KRTAP18-8, KRTAP18.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-8 (Keratin-associated protein 10.8) (High sulfur keratin-associated protein 10.8) (Keratin-associated protein 18-8) (Keratin-associated protein 18.8).

KR109_HUMAN
θ value	θ > 10 (rank : 71)	NC score	0.051591 (rank : 53)
Query Neighborhood Hits	56	Target Neighborhood Hits	226	Shared Neighborhood Hits	2
SwissProt Accessions	P60411, Q70LJ1	Gene names	KRTAP10-9, KAP10.9, KAP18-9, KRTAP10.9, KRTAP18-9, KRTAP18.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-9 (Keratin-associated protein 10.9) (High sulfur keratin-associated protein 10.9) (Keratin-associated protein 18-9) (Keratin-associated protein 18.9).

KR410_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.055936 (rank : 45)
Query Neighborhood Hits	56	Target Neighborhood Hits	156	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BYQ7	Gene names	KRTAP4-10, KAP4.10, KRTAP4.10
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-10 (Keratin-associated protein 4.10) (Ultrahigh sulfur keratin-associated protein 4.10).

KR510_HUMAN
θ value	θ > 10 (rank : 73)	NC score	0.065821 (rank : 33)
Query Neighborhood Hits	56	Target Neighborhood Hits	217	Shared Neighborhood Hits	2
SwissProt Accessions	Q6L8G5	Gene names	KRTAP5-10, KAP5.10, KRTAP5.10
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-10 (Keratin-associated protein 5.10) (Ultrahigh sulfur keratin-associated protein 5.10).

KRA45_HUMAN
θ value	θ > 10 (rank : 74)	NC score	0.052703 (rank : 48)
Query Neighborhood Hits	56	Target Neighborhood Hits	194	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BYR2	Gene names	KRTAP4-5, KAP4.5, KRTAP4.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-5 (Keratin-associated protein 4.5) (Ultrahigh sulfur keratin-associated protein 4.5).

KRA47_HUMAN
θ value	θ > 10 (rank : 75)	NC score	0.052113 (rank : 51)
Query Neighborhood Hits	56	Target Neighborhood Hits	204	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BYR0	Gene names	KRTAP4-7, KAP4.7, KRTAP4.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-7 (Keratin-associated protein 4.7) (Ultrahigh sulfur keratin-associated protein 4.7).

KRA51_HUMAN
θ value	θ > 10 (rank : 76)	NC score	0.081812 (rank : 25)
Query Neighborhood Hits	56	Target Neighborhood Hits	288	Shared Neighborhood Hits	4
SwissProt Accessions	Q6L8H4	Gene names	KRTAP5-1, KAP5.1, KRTAP5.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-1 (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1).

KRA52_HUMAN
θ value	θ > 10 (rank : 77)	NC score	0.084156 (rank : 23)
Query Neighborhood Hits	56	Target Neighborhood Hits	236	Shared Neighborhood Hits	4
SwissProt Accessions	Q701N4	Gene names	KRTAP5-2, KAP5-8, KAP5.2, KRTAP5-8, KRTAP5.2, KRTAP5.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-2 (Keratin-associated protein 5.2) (Ultrahigh sulfur keratin-associated protein 5.2) (Keratin-associated protein 5-8) (Keratin-associated protein 5.8).

KRA53_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.056525 (rank : 44)
Query Neighborhood Hits	56	Target Neighborhood Hits	331	Shared Neighborhood Hits	4
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

KRA54_HUMAN
θ value	θ > 10 (rank : 79)	NC score	0.082855 (rank : 24)
Query Neighborhood Hits	56	Target Neighborhood Hits	270	Shared Neighborhood Hits	4
SwissProt Accessions	Q6L8H1	Gene names	KRTAP5-4, KAP5.4, KRTAP5.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-4 (Keratin-associated protein 5.4) (Ultrahigh sulfur keratin-associated protein 5.4).

KRA55_HUMAN
θ value	θ > 10 (rank : 80)	NC score	0.080370 (rank : 26)
Query Neighborhood Hits	56	Target Neighborhood Hits	257	Shared Neighborhood Hits	2
SwissProt Accessions	Q701N2	Gene names	KRTAP5-5, KAP5-11, KAP5.5, KRTAP5-11, KRTAP5.11, KRTAP5.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-5 (Keratin-associated protein 5.5) (Ultrahigh sulfur keratin-associated protein 5.5) (Keratin-associated protein 5-11) (Keratin-associated protein 5.11).

KRA56_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.068497 (rank : 30)
Query Neighborhood Hits	56	Target Neighborhood Hits	207	Shared Neighborhood Hits	4
SwissProt Accessions	Q6L8G9	Gene names	KRTAP5-6, KAP5.6, KRTAP5.6
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-6 (Keratin-associated protein 5.6) (Ultrahigh sulfur keratin-associated protein 5.6).

KRA57_HUMAN
θ value	θ > 10 (rank : 82)	NC score	0.060644 (rank : 40)
Query Neighborhood Hits	56	Target Neighborhood Hits	269	Shared Neighborhood Hits	4
SwissProt Accessions	Q6L8G8, Q701N5	Gene names	KRTAP5-7, KAP5-7, KAP5.3, KRTAP5.3, KRTAP5.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-7 (Keratin-associated protein 5.7) (Ultrahigh sulfur keratin-associated protein 5.7) (Keratin-associated protein 5-3) (Keratin-associated protein 5.3).

KRA58_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.050482 (rank : 57)
Query Neighborhood Hits	56	Target Neighborhood Hits	324	Shared Neighborhood Hits	4
SwissProt Accessions	O75690, Q6L8G7, Q6UTX6	Gene names	KRTAP5-8, KAP5.8, KRTAP5.8, UHSKB
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-8 (Keratin-associated protein 5.8) (Ultrahigh sulfur keratin-associated protein 5.8) (Keratin, ultra high-sulfur matrix protein B) (UHS keratin B) (UHS KerB).

KRA59_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.059058 (rank : 41)
Query Neighborhood Hits	56	Target Neighborhood Hits	310	Shared Neighborhood Hits	4
SwissProt Accessions	P26371, Q14564	Gene names	KRTAP5-9, KAP5.9, KRN1, KRTAP5.9, UHSK1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-9 (Keratin-associated protein 5.9) (Ultrahigh sulfur keratin-associated protein 5.9) (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (UHS keratin A) (UHS KerA).

LCE5A_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.052573 (rank : 49)
Query Neighborhood Hits	56	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	Q5TCM9	Gene names	LCE5A, LEP18, SPRL5A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 5A (Late envelope protein 18) (Small proline-rich-like epidermal differentiation complex protein 5A).

PCSK5_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.062830 (rank : 35)
Query Neighborhood Hits	56	Target Neighborhood Hits	291	Shared Neighborhood Hits	3
SwissProt Accessions	Q92824, Q13527	Gene names	PCSK5, PC5, PC6
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (hPC6).

PCSK5_MOUSE
θ value	θ > 10 (rank : 87)	NC score	0.079634 (rank : 27)
Query Neighborhood Hits	56	Target Neighborhood Hits	613	Shared Neighborhood Hits	4
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

PCSK6_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.061247 (rank : 39)
Query Neighborhood Hits	56	Target Neighborhood Hits	298	Shared Neighborhood Hits	3
SwissProt Accessions	P29122, Q15099, Q15100, Q9UEG7, Q9UEJ1, Q9UEJ2, Q9UEJ7, Q9UEJ8, Q9UEJ9, Q9Y4G9, Q9Y4H0, Q9Y4H1	Gene names	PCSK6, PACE4
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4).

REG3G_MOUSE
θ value	θ > 10 (rank : 89)	NC score	0.051487 (rank : 54)
Query Neighborhood Hits	56	Target Neighborhood Hits	91	Shared Neighborhood Hits	2
SwissProt Accessions	O09049	Gene names	Reg3g, Pap3
Domain Architecture
Description	Regenerating islet-derived protein 3 gamma precursor (Reg III-gamma) (Pancreatitis-associated protein 3).

RSPO2_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.055086 (rank : 46)
Query Neighborhood Hits	56	Target Neighborhood Hits	90	Shared Neighborhood Hits	2
SwissProt Accessions	Q6UXX9, Q4G0U4, Q8N6X6	Gene names	RSPO2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (hRspo2).

RSPO2_MOUSE
θ value	θ > 10 (rank : 91)	NC score	0.054710 (rank : 47)
Query Neighborhood Hits	56	Target Neighborhood Hits	88	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BFU0, Q7TPX3	Gene names	Rspo2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (Cysteine-rich and single thrombospondin domain-containing protein 2) (Cristin-2) (mCristin-2).

RSPO3_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.051800 (rank : 52)
Query Neighborhood Hits	56	Target Neighborhood Hits	128	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BXY4, Q5VTV4, Q96K87	Gene names	RSPO3, PWTSR, THSD2
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2) (Protein with TSP type-1 repeat) (hPWTSR).

RSPO3_MOUSE
θ value	θ > 10 (rank : 93)	NC score	0.051187 (rank : 55)
Query Neighborhood Hits	56	Target Neighborhood Hits	120	Shared Neighborhood Hits	2
SwissProt Accessions	Q2TJ95, Q3SYI9, Q5R2V4, Q8BVW2, Q9CSB2	Gene names	Rspo3
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (Cysteine-rich and single thrombospondin domain-containing protein 1) (Cristin-1) (Nucleopondin) (Cabriolet).

RSPO4_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.062282 (rank : 36)
Query Neighborhood Hits	56	Target Neighborhood Hits	110	Shared Neighborhood Hits	2
SwissProt Accessions	Q2I0M5, Q9UGB2	Gene names	RSPO4, C20orf182
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (hRspo4).

RSPO4_MOUSE
θ value	θ > 10 (rank : 95)	NC score	0.062271 (rank : 37)
Query Neighborhood Hits	56	Target Neighborhood Hits	110	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BJ73	Gene names	Rspo4
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (Cysteine-rich and single thrombospondin domain-containing protein 4) (Cristin-4) (mCristin-4).

ZAN_MOUSE
θ value	θ > 10 (rank : 96)	NC score	0.050510 (rank : 56)
Query Neighborhood Hits	56	Target Neighborhood Hits	808	Shared Neighborhood Hits	9
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

Hits sorted by NC score

FREM3_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 5)
Query Neighborhood Hits	56	Target Neighborhood Hits	56	Shared Neighborhood Hits	56
SwissProt Accessions	P0C091	Gene names	FREM3
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 3 precursor.

FREM3_MOUSE
NC score	0.994776 (rank : 2)	θ value	0 (rank : 6)
Query Neighborhood Hits	56	Target Neighborhood Hits	49	Shared Neighborhood Hits	22
SwissProt Accessions	Q5H8B9	Gene names	Frem3, Nv2
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 3 precursor (NV domain- containing protein 2).

FREM2_HUMAN
NC score	0.987862 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	56	Target Neighborhood Hits	76	Shared Neighborhood Hits	25
SwissProt Accessions	Q5SZK8, Q4QQG1, Q5H9N8, Q5T6Q1, Q6N057, Q6ZSB4, Q7Z305, Q7Z341	Gene names	FREM2
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 2 precursor (ECM3 homolog).

FREM2_MOUSE
NC score	0.986497 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	56	Target Neighborhood Hits	73	Shared Neighborhood Hits	23
SwissProt Accessions	Q6NVD0, Q4W2Q5, Q5H8C0, Q811G9, Q8C4G5, Q8CD46	Gene names	Frem2, Nv1
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 2 precursor (ECM3 homolog) (NV domain-containing protein 1).

FREM1_HUMAN
NC score	0.871556 (rank : 5)	θ value	0 (rank : 1)
Query Neighborhood Hits	56	Target Neighborhood Hits	170	Shared Neighborhood Hits	19
SwissProt Accessions	Q5H8C1, Q5VV00, Q5VV01, Q6MZI4, Q8NEG9, Q96LI3	Gene names	FREM1, C9orf154
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 1 precursor (Protein QBRICK).

FREM1_MOUSE
NC score	0.858746 (rank : 6)	θ value	0 (rank : 2)
Query Neighborhood Hits	56	Target Neighborhood Hits	163	Shared Neighborhood Hits	20
SwissProt Accessions	Q684R7, Q5H8C2, Q5M7B3, Q8C732	Gene names	Frem1
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 1 precursor (Protein QBRICK).

CSPG4_HUMAN
NC score	0.721350 (rank : 7)	θ value	1.72781e-51 (rank : 9)
Query Neighborhood Hits	56	Target Neighborhood Hits	112	Shared Neighborhood Hits	13
SwissProt Accessions	Q6UVK1, Q92675	Gene names	CSPG4, MCSP
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 4 precursor (Chondroitin sulfate proteoglycan NG2) (Melanoma chondroitin sulfate proteoglycan) (Melanoma-associated chondroitin sulfate proteoglycan).

CSPG4_MOUSE
NC score	0.709507 (rank : 8)	θ value	1.72781e-51 (rank : 10)
Query Neighborhood Hits	56	Target Neighborhood Hits	105	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VHY0, Q5DTG1, Q8BPI8, Q8CE79	Gene names	Cspg4, An2, Kiaa4232, Ng2
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 4 precursor (Chondroitin sulfate proteoglycan NG2) (AN2 proteoglycan).

FRAS1_HUMAN
NC score	0.644857 (rank : 9)	θ value	1.0077e-184 (rank : 7)
Query Neighborhood Hits	56	Target Neighborhood Hits	759	Shared Neighborhood Hits	22
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

FRAS1_MOUSE
NC score	0.638296 (rank : 10)	θ value	5.01279e-176 (rank : 8)
Query Neighborhood Hits	56	Target Neighborhood Hits	747	Shared Neighborhood Hits	19
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

NAC1_HUMAN
NC score	0.386870 (rank : 11)	θ value	8.67504e-11 (rank : 12)
Query Neighborhood Hits	56	Target Neighborhood Hits	43	Shared Neighborhood Hits	15
SwissProt Accessions	P32418, O95849, Q9UBL8, Q9UDN1, Q9UDN2, Q9UKX6	Gene names	SLC8A1, CNC, NCX1
Domain Architecture
Description	Sodium/calcium exchanger 1 precursor (Na(+)/Ca(2+)-exchange protein 1).

NAC1_MOUSE
NC score	0.380023 (rank : 12)	θ value	2.98157e-11 (rank : 11)
Query Neighborhood Hits	56	Target Neighborhood Hits	41	Shared Neighborhood Hits	15
SwissProt Accessions	P70414	Gene names	Slc8a1, Ncx
Domain Architecture
Description	Sodium/calcium exchanger 1 precursor (Na(+)/Ca(2+)-exchange protein 1).

NAC3_HUMAN
NC score	0.369406 (rank : 13)	θ value	1.63604e-09 (rank : 14)
Query Neighborhood Hits	56	Target Neighborhood Hits	42	Shared Neighborhood Hits	15
SwissProt Accessions	P57103, Q8IUE9, Q8IUF0, Q8NFI7	Gene names	SLC8A3, NCX3
Domain Architecture
Description	Sodium/calcium exchanger 3 precursor (Na(+)/Ca(2+)-exchange protein 3).

NAC2_HUMAN
NC score	0.342188 (rank : 14)	θ value	4.0297e-08 (rank : 15)
Query Neighborhood Hits	56	Target Neighborhood Hits	33	Shared Neighborhood Hits	15
SwissProt Accessions	Q9UPR5	Gene names	SLC8A2, KIAA1087, NCX2
Domain Architecture
Description	Sodium/calcium exchanger 2 precursor (Na(+)/Ca(2+)-exchange protein 2).

GPR98_MOUSE
NC score	0.301539 (rank : 15)	θ value	7.34386e-10 (rank : 13)
Query Neighborhood Hits	56	Target Neighborhood Hits	206	Shared Neighborhood Hits	19
SwissProt Accessions	Q8VHN7, Q6ZQ69, Q810D2, Q810D3, Q91ZS0, Q91ZS1	Gene names	Gpr98, Kiaa0686, Mass1, Vlgr1
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor 98 precursor (Monogenic audiogenic seizure susceptibility protein 1) (Very large G-protein coupled receptor 1) (Neurepin).

GPR98_HUMAN
NC score	0.288885 (rank : 16)	θ value	2.21117e-06 (rank : 16)
Query Neighborhood Hits	56	Target Neighborhood Hits	202	Shared Neighborhood Hits	18
SwissProt Accessions	Q8WXG9, O75171, Q9H0X5, Q9UL61	Gene names	GPR98, KIAA0686, MASS1, VLGR1
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor 98 precursor (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Very large G-protein coupled receptor 1) (Usher syndrome type-2C protein).

ITB4_HUMAN
NC score	0.092849 (rank : 17)	θ value	0.000158464 (rank : 17)
Query Neighborhood Hits	56	Target Neighborhood Hits	458	Shared Neighborhood Hits	21
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

BMPER_HUMAN
NC score	0.090420 (rank : 18)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	56	Target Neighborhood Hits	175	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N8U9	Gene names	BMPER
Domain Architecture
Description	BMP-binding endothelial regulator protein precursor (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (hCV2).

CHRD_HUMAN
NC score	0.090382 (rank : 19)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	56	Target Neighborhood Hits	102	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H2X0, O95254, Q6UW83, Q9H2D3, Q9H2W8, Q9H2W9, Q9P0Z2, Q9P0Z3, Q9P0Z4, Q9P0Z5	Gene names	CHRD
Domain Architecture
Description	Chordin precursor.

CHRD_MOUSE
NC score	0.086009 (rank : 20)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	56	Target Neighborhood Hits	102	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z0E2	Gene names	Chrd
Domain Architecture
Description	Chordin precursor.

BMPER_MOUSE
NC score	0.085016 (rank : 21)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	56	Target Neighborhood Hits	194	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CJ69, Q7TN57, Q80UZ1, Q9CXM8	Gene names	Bmper, Cv2
Domain Architecture
Description	BMP-binding endothelial regulator protein precursor (Bone morphogenetic protein-binding endothelial cell precursor-derived regulator) (Protein crossveinless-2) (mCV2).

CRIM1_HUMAN
NC score	0.084697 (rank : 22)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	56	Target Neighborhood Hits	362	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZV1, Q59GH0, Q7LCQ5, Q9H318	Gene names	CRIM1
Domain Architecture	No domain graphic available
Description	Cysteine-rich motor neuron 1 protein precursor (CRIM-1) (Cysteine-rich repeat-containing protein S52).

KRA52_HUMAN
NC score	0.084156 (rank : 23)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	56	Target Neighborhood Hits	236	Shared Neighborhood Hits	4
SwissProt Accessions	Q701N4	Gene names	KRTAP5-2, KAP5-8, KAP5.2, KRTAP5-8, KRTAP5.2, KRTAP5.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-2 (Keratin-associated protein 5.2) (Ultrahigh sulfur keratin-associated protein 5.2) (Keratin-associated protein 5-8) (Keratin-associated protein 5.8).

KRA54_HUMAN
NC score	0.082855 (rank : 24)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	56	Target Neighborhood Hits	270	Shared Neighborhood Hits	4
SwissProt Accessions	Q6L8H1	Gene names	KRTAP5-4, KAP5.4, KRTAP5.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-4 (Keratin-associated protein 5.4) (Ultrahigh sulfur keratin-associated protein 5.4).

KRA51_HUMAN
NC score	0.081812 (rank : 25)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	56	Target Neighborhood Hits	288	Shared Neighborhood Hits	4
SwissProt Accessions	Q6L8H4	Gene names	KRTAP5-1, KAP5.1, KRTAP5.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-1 (Keratin-associated protein 5.1) (Ultrahigh sulfur keratin-associated protein 5.1).

KRA55_HUMAN
NC score	0.080370 (rank : 26)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	56	Target Neighborhood Hits	257	Shared Neighborhood Hits	2
SwissProt Accessions	Q701N2	Gene names	KRTAP5-5, KAP5-11, KAP5.5, KRTAP5-11, KRTAP5.11, KRTAP5.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-5 (Keratin-associated protein 5.5) (Ultrahigh sulfur keratin-associated protein 5.5) (Keratin-associated protein 5-11) (Keratin-associated protein 5.11).

PCSK5_MOUSE
NC score	0.079634 (rank : 27)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	56	Target Neighborhood Hits	613	Shared Neighborhood Hits	4
SwissProt Accessions	Q04592, Q62040	Gene names	Pcsk5
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (Subtilisin-like proprotein convertase 6) (SPC6).

CRDL1_HUMAN
NC score	0.071269 (rank : 28)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	56	Target Neighborhood Hits	75	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BU40, Q9Y3H7	Gene names	CHRDL1, NRLN1
Domain Architecture
Description	Chordin-like protein 1 precursor (Neuralin-1) (Ventroptin) (Neurogenesin-1).

CRDL2_HUMAN
NC score	0.071260 (rank : 29)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	56	Target Neighborhood Hits	99	Shared Neighborhood Hits	2
SwissProt Accessions	Q6WN34, Q6WN30, Q6WN31, Q6WN32, Q7Z5J3	Gene names	CHRDL2, BNF1, CHL2
Domain Architecture	No domain graphic available
Description	Chordin-like protein 2 precursor (Chordin-related protein 2) (Breast tumor novel factor 1) (BNF-1).

KRA56_HUMAN
NC score	0.068497 (rank : 30)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	56	Target Neighborhood Hits	207	Shared Neighborhood Hits	4
SwissProt Accessions	Q6L8G9	Gene names	KRTAP5-6, KAP5.6, KRTAP5.6
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-6 (Keratin-associated protein 5.6) (Ultrahigh sulfur keratin-associated protein 5.6).

CRDL2_MOUSE
NC score	0.066770 (rank : 31)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	56	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VEA6, Q925I3	Gene names	Chrdl2, Chl2
Domain Architecture	No domain graphic available
Description	Chordin-like protein 2 precursor.

KR108_HUMAN
NC score	0.065839 (rank : 32)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	56	Target Neighborhood Hits	226	Shared Neighborhood Hits	2
SwissProt Accessions	P60410	Gene names	KRTAP10-8, KAP10.8, KAP18-8, KRTAP10.8, KRTAP18-8, KRTAP18.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-8 (Keratin-associated protein 10.8) (High sulfur keratin-associated protein 10.8) (Keratin-associated protein 18-8) (Keratin-associated protein 18.8).

KR510_HUMAN
NC score	0.065821 (rank : 33)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	56	Target Neighborhood Hits	217	Shared Neighborhood Hits	2
SwissProt Accessions	Q6L8G5	Gene names	KRTAP5-10, KAP5.10, KRTAP5.10
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-10 (Keratin-associated protein 5.10) (Ultrahigh sulfur keratin-associated protein 5.10).

CRDL1_MOUSE
NC score	0.064569 (rank : 34)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	56	Target Neighborhood Hits	81	Shared Neighborhood Hits	2
SwissProt Accessions	Q920C1, Q924K0, Q9EPZ9	Gene names	Chrdl1, Ng1, Nrln1
Domain Architecture
Description	Chordin-like protein 1 precursor (Neuralin-1) (Ventroptin) (Neurogenesin-1).

PCSK5_HUMAN
NC score	0.062830 (rank : 35)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	56	Target Neighborhood Hits	291	Shared Neighborhood Hits	3
SwissProt Accessions	Q92824, Q13527	Gene names	PCSK5, PC5, PC6
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 5 precursor (EC 3.4.21.-) (Proprotein convertase PC5) (Subtilisin/kexin-like protease PC5) (PC6) (hPC6).

RSPO4_HUMAN
NC score	0.062282 (rank : 36)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	56	Target Neighborhood Hits	110	Shared Neighborhood Hits	2
SwissProt Accessions	Q2I0M5, Q9UGB2	Gene names	RSPO4, C20orf182
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (hRspo4).

RSPO4_MOUSE
NC score	0.062271 (rank : 37)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	56	Target Neighborhood Hits	110	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BJ73	Gene names	Rspo4
Domain Architecture	No domain graphic available
Description	R-spondin-4 precursor (Roof plate-specific spondin-4) (Cysteine-rich and single thrombospondin domain-containing protein 4) (Cristin-4) (mCristin-4).

KR104_HUMAN
NC score	0.061774 (rank : 38)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	56	Target Neighborhood Hits	313	Shared Neighborhood Hits	2
SwissProt Accessions	P60372	Gene names	KRTAP10-4, KAP10.4, KAP18-4, KRTAP10.4, KRTAP18-4, KRTAP18.4
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-4 (Keratin-associated protein 10.4) (High sulfur keratin-associated protein 10.4) (Keratin-associated protein 18-4) (Keratin-associated protein 18.4).

PCSK6_HUMAN
NC score	0.061247 (rank : 39)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	56	Target Neighborhood Hits	298	Shared Neighborhood Hits	3
SwissProt Accessions	P29122, Q15099, Q15100, Q9UEG7, Q9UEJ1, Q9UEJ2, Q9UEJ7, Q9UEJ8, Q9UEJ9, Q9Y4G9, Q9Y4H0, Q9Y4H1	Gene names	PCSK6, PACE4
Domain Architecture
Description	Proprotein convertase subtilisin/kexin type 6 precursor (EC 3.4.21.-) (Paired basic amino acid cleaving enzyme 4) (Subtilisin/kexin-like protease PACE4) (Subtilisin-like proprotein convertase 4) (SPC4).

KRA57_HUMAN
NC score	0.060644 (rank : 40)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	56	Target Neighborhood Hits	269	Shared Neighborhood Hits	4
SwissProt Accessions	Q6L8G8, Q701N5	Gene names	KRTAP5-7, KAP5-7, KAP5.3, KRTAP5.3, KRTAP5.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-7 (Keratin-associated protein 5.7) (Ultrahigh sulfur keratin-associated protein 5.7) (Keratin-associated protein 5-3) (Keratin-associated protein 5.3).

KRA59_HUMAN
NC score	0.059058 (rank : 41)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	56	Target Neighborhood Hits	310	Shared Neighborhood Hits	4
SwissProt Accessions	P26371, Q14564	Gene names	KRTAP5-9, KAP5.9, KRN1, KRTAP5.9, UHSK1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-9 (Keratin-associated protein 5.9) (Ultrahigh sulfur keratin-associated protein 5.9) (Keratin, cuticle, ultrahigh sulfur 1) (Keratin, ultra high-sulfur matrix protein A) (UHS keratin A) (UHS KerA).

KR107_HUMAN
NC score	0.058260 (rank : 42)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	56	Target Neighborhood Hits	330	Shared Neighborhood Hits	2
SwissProt Accessions	P60409, Q70LJ2	Gene names	KRTAP10-7, KAP10.7, KAP18-7, KRTAP10.7, KRTAP18-7, KRTAP18.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-7 (Keratin-associated protein 10.7) (High sulfur keratin-associated protein 10.7) (Keratin-associated protein 18-7) (Keratin-associated protein 18.7).

KR101_HUMAN
NC score	0.057930 (rank : 43)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	56	Target Neighborhood Hits	261	Shared Neighborhood Hits	2
SwissProt Accessions	P60331	Gene names	KRTAP10-1, KAP10.1, KAP18-1, KRTAP10.1, KRTAP18-1, KRTAP18.1
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-1 (Keratin-associated protein 10.1) (High sulfur keratin-associated protein 10.1) (Keratin-associated protein 18-1) (Keratin-associated protein 18.1).

KRA53_HUMAN
NC score	0.056525 (rank : 44)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	56	Target Neighborhood Hits	331	Shared Neighborhood Hits	4
SwissProt Accessions	Q6L8H2, Q6PL44, Q701N3	Gene names	KRTAP5-3, KAP5-9, KAP5.3, KRTAP5-9, KRTAP5.3, KRTAP5.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-3 (Keratin-associated protein 5.3) (Ultrahigh sulfur keratin-associated protein 5.3) (Keratin-associated protein 5-9) (Keratin-associated protein 5.9) (UHS KerB-like).

KR410_HUMAN
NC score	0.055936 (rank : 45)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	56	Target Neighborhood Hits	156	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BYQ7	Gene names	KRTAP4-10, KAP4.10, KRTAP4.10
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-10 (Keratin-associated protein 4.10) (Ultrahigh sulfur keratin-associated protein 4.10).

RSPO2_HUMAN
NC score	0.055086 (rank : 46)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	56	Target Neighborhood Hits	90	Shared Neighborhood Hits	2
SwissProt Accessions	Q6UXX9, Q4G0U4, Q8N6X6	Gene names	RSPO2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (hRspo2).

RSPO2_MOUSE
NC score	0.054710 (rank : 47)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	56	Target Neighborhood Hits	88	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BFU0, Q7TPX3	Gene names	Rspo2
Domain Architecture	No domain graphic available
Description	R-spondin-2 precursor (Roof plate-specific spondin-2) (Cysteine-rich and single thrombospondin domain-containing protein 2) (Cristin-2) (mCristin-2).

KRA45_HUMAN
NC score	0.052703 (rank : 48)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	56	Target Neighborhood Hits	194	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BYR2	Gene names	KRTAP4-5, KAP4.5, KRTAP4.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-5 (Keratin-associated protein 4.5) (Ultrahigh sulfur keratin-associated protein 4.5).

LCE5A_HUMAN
NC score	0.052573 (rank : 49)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	56	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	Q5TCM9	Gene names	LCE5A, LEP18, SPRL5A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 5A (Late envelope protein 18) (Small proline-rich-like epidermal differentiation complex protein 5A).

KR105_HUMAN
NC score	0.052113 (rank : 50)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	56	Target Neighborhood Hits	271	Shared Neighborhood Hits	2
SwissProt Accessions	P60370, Q70LJ3	Gene names	KRTAP10-5, KAP10.5, KAP18-5, KRTAP10.5, KRTAP18-5, KRTAP18.5
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-5 (Keratin-associated protein 10.5) (High sulfur keratin-associated protein 10.5) (Keratin-associated protein 18-5) (Keratin-associated protein 18.5).

KRA47_HUMAN
NC score	0.052113 (rank : 51)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	56	Target Neighborhood Hits	204	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BYR0	Gene names	KRTAP4-7, KAP4.7, KRTAP4.7
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 4-7 (Keratin-associated protein 4.7) (Ultrahigh sulfur keratin-associated protein 4.7).

RSPO3_HUMAN
NC score	0.051800 (rank : 52)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	56	Target Neighborhood Hits	128	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BXY4, Q5VTV4, Q96K87	Gene names	RSPO3, PWTSR, THSD2
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2) (Protein with TSP type-1 repeat) (hPWTSR).

KR109_HUMAN
NC score	0.051591 (rank : 53)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	56	Target Neighborhood Hits	226	Shared Neighborhood Hits	2
SwissProt Accessions	P60411, Q70LJ1	Gene names	KRTAP10-9, KAP10.9, KAP18-9, KRTAP10.9, KRTAP18-9, KRTAP18.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 10-9 (Keratin-associated protein 10.9) (High sulfur keratin-associated protein 10.9) (Keratin-associated protein 18-9) (Keratin-associated protein 18.9).

REG3G_MOUSE
NC score	0.051487 (rank : 54)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	56	Target Neighborhood Hits	91	Shared Neighborhood Hits	2
SwissProt Accessions	O09049	Gene names	Reg3g, Pap3
Domain Architecture
Description	Regenerating islet-derived protein 3 gamma precursor (Reg III-gamma) (Pancreatitis-associated protein 3).

RSPO3_MOUSE
NC score	0.051187 (rank : 55)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	56	Target Neighborhood Hits	120	Shared Neighborhood Hits	2
SwissProt Accessions	Q2TJ95, Q3SYI9, Q5R2V4, Q8BVW2, Q9CSB2	Gene names	Rspo3
Domain Architecture	No domain graphic available
Description	R-spondin-3 precursor (Roof plate-specific spondin-3) (Cysteine-rich and single thrombospondin domain-containing protein 1) (Cristin-1) (Nucleopondin) (Cabriolet).

ZAN_MOUSE
NC score	0.050510 (rank : 56)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	56	Target Neighborhood Hits	808	Shared Neighborhood Hits	9
SwissProt Accessions	O88799, O08647	Gene names	Zan
Domain Architecture
Description	Zonadhesin precursor.

KRA58_HUMAN
NC score	0.050482 (rank : 57)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	56	Target Neighborhood Hits	324	Shared Neighborhood Hits	4
SwissProt Accessions	O75690, Q6L8G7, Q6UTX6	Gene names	KRTAP5-8, KAP5.8, KRTAP5.8, UHSKB
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 5-8 (Keratin-associated protein 5.8) (Ultrahigh sulfur keratin-associated protein 5.8) (Keratin, ultra high-sulfur matrix protein B) (UHS keratin B) (UHS KerB).

RSMN_HUMAN
NC score	0.045298 (rank : 58)	θ value	0.125558 (rank : 19)
Query Neighborhood Hits	56	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	P63162, P14648, P17135	Gene names	SNRPN, HCERN3, SMN
Domain Architecture	No domain graphic available
Description	Small nuclear ribonucleoprotein-associated protein N (snRNP-N) (Sm protein N) (Sm-N) (SmN) (Sm-D) (Tissue-specific-splicing protein).

RSMN_MOUSE
NC score	0.045298 (rank : 59)	θ value	0.125558 (rank : 20)
Query Neighborhood Hits	56	Target Neighborhood Hits	110	Shared Neighborhood Hits	5
SwissProt Accessions	P63163, P14648, P17135	Gene names	Snrpn, Smn
Domain Architecture	No domain graphic available
Description	Small nuclear ribonucleoprotein-associated protein N (snRNP-N) (Sm protein N) (Sm-N) (SmN) (Sm-D) (Tissue-specific-splicing protein).

FAT2_HUMAN
NC score	0.033212 (rank : 60)	θ value	0.21417 (rank : 21)
Query Neighborhood Hits	56	Target Neighborhood Hits	507	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NYQ8, O75091, Q9NSR7	Gene names	FAT2, CDHF8, KIAA0811, MEGF1
Domain Architecture
Description	Protocadherin Fat 2 precursor (hFat2) (Multiple epidermal growth factor-like domains 1).

TNR16_MOUSE
NC score	0.032384 (rank : 61)	θ value	8.99809 (rank : 55)
Query Neighborhood Hits	56	Target Neighborhood Hits	178	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z0W1	Gene names	Ngfr, Tnfrsf16
Domain Architecture
Description	Tumor necrosis factor receptor superfamily member 16 precursor (Low- affinity nerve growth factor receptor) (NGF receptor) (Low affinity neurotrophin receptor p75NTR).

RSMB_MOUSE
NC score	0.031192 (rank : 62)	θ value	5.27518 (rank : 42)
Query Neighborhood Hits	56	Target Neighborhood Hits	93	Shared Neighborhood Hits	5
SwissProt Accessions	P27048, Q3UJT1	Gene names	Snrpb
Domain Architecture
Description	Small nuclear ribonucleoprotein-associated protein B (snRNP-B) (Sm protein B) (Sm-B) (SmB).

CAD23_MOUSE
NC score	0.029639 (rank : 63)	θ value	6.88961 (rank : 46)
Query Neighborhood Hits	56	Target Neighborhood Hits	208	Shared Neighborhood Hits	20
SwissProt Accessions	Q99PF4, Q99NH1, Q9D4N9	Gene names	Cdh23
Domain Architecture
Description	Cadherin-23 precursor (Otocadherin).

RSMB_HUMAN
NC score	0.028330 (rank : 64)	θ value	8.99809 (rank : 52)
Query Neighborhood Hits	56	Target Neighborhood Hits	117	Shared Neighborhood Hits	5
SwissProt Accessions	P14678, Q15490, Q9UIS5	Gene names	SNRPB, COD, SNRPB1
Domain Architecture
Description	Small nuclear ribonucleoprotein-associated proteins B and B' (snRNP-B) (Sm protein B/B') (Sm-B/Sm-B') (SmB/SmB').

PCD15_HUMAN
NC score	0.027909 (rank : 65)	θ value	0.0252991 (rank : 18)
Query Neighborhood Hits	56	Target Neighborhood Hits	289	Shared Neighborhood Hits	14
SwissProt Accessions	Q96QU1, Q96QT8	Gene names	PCDH15
Domain Architecture
Description	Protocadherin-15 precursor.

PCDH9_HUMAN
NC score	0.023630 (rank : 66)	θ value	1.06291 (rank : 26)
Query Neighborhood Hits	56	Target Neighborhood Hits	180	Shared Neighborhood Hits	15
SwissProt Accessions	Q9HC56	Gene names	PCDH9
Domain Architecture
Description	Protocadherin-9 precursor.

OPLA_MOUSE
NC score	0.023172 (rank : 67)	θ value	4.03905 (rank : 36)
Query Neighborhood Hits	56	Target Neighborhood Hits	14	Shared Neighborhood Hits	4
SwissProt Accessions	Q8K010, Q8R3K2	Gene names	Oplah
Domain Architecture
Description	5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (Pyroglutamase) (5- OPase).

OPLA_HUMAN
NC score	0.023117 (rank : 68)	θ value	4.03905 (rank : 35)
Query Neighborhood Hits	56	Target Neighborhood Hits	17	Shared Neighborhood Hits	4
SwissProt Accessions	O14841, Q75W65, Q9Y4Q0	Gene names	OPLAH
Domain Architecture	No domain graphic available
Description	5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (Pyroglutamase) (5- OPase).

PCD16_HUMAN
NC score	0.022315 (rank : 69)	θ value	6.88961 (rank : 47)
Query Neighborhood Hits	56	Target Neighborhood Hits	245	Shared Neighborhood Hits	19
SwissProt Accessions	Q96JQ0, O15098	Gene names	DCHS1, CDH19, FIB1, KIAA1773, PCDH16
Domain Architecture
Description	Protocadherin-16 precursor (Dachsous 1) (Cadherin-19) (Fibroblast cadherin 1).

P4HA2_HUMAN
NC score	0.015851 (rank : 70)	θ value	1.06291 (rank : 25)
Query Neighborhood Hits	56	Target Neighborhood Hits	23	Shared Neighborhood Hits	2
SwissProt Accessions	O15460, Q8WWN0	Gene names	P4HA2
Domain Architecture
Description	Prolyl 4-hydroxylase alpha-2 subunit precursor (EC 1.14.11.2) (4-PH alpha-2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase alpha-2 subunit).

PCDGA_HUMAN
NC score	0.015438 (rank : 71)	θ value	0.365318 (rank : 23)
Query Neighborhood Hits	56	Target Neighborhood Hits	160	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y5H3, Q9Y5E0	Gene names	PCDHGA10
Domain Architecture
Description	Protocadherin gamma A10 precursor (PCDH-gamma-A10).

PCDG3_HUMAN
NC score	0.015327 (rank : 72)	θ value	0.279714 (rank : 22)
Query Neighborhood Hits	56	Target Neighborhood Hits	155	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y5H0, Q9Y5D4	Gene names	PCDHGA3
Domain Architecture
Description	Protocadherin gamma A3 precursor (PCDH-gamma-A3).

PCDH1_HUMAN
NC score	0.012460 (rank : 73)	θ value	3.0926 (rank : 33)
Query Neighborhood Hits	56	Target Neighborhood Hits	174	Shared Neighborhood Hits	11
SwissProt Accessions	Q08174	Gene names	PCDH1
Domain Architecture
Description	Protocadherin-1 precursor (Protocadherin-42) (PC42) (Cadherin-like protein 1).

DSC1_HUMAN
NC score	0.011208 (rank : 74)	θ value	1.38821 (rank : 27)
Query Neighborhood Hits	56	Target Neighborhood Hits	154	Shared Neighborhood Hits	12
SwissProt Accessions	Q08554	Gene names	DSC1
Domain Architecture
Description	Desmocollin-1 precursor (Desmosomal glycoprotein 2/3) (DG2/DG3).

PTPRM_HUMAN
NC score	0.009999 (rank : 75)	θ value	1.81305 (rank : 28)
Query Neighborhood Hits	56	Target Neighborhood Hits	244	Shared Neighborhood Hits	7
SwissProt Accessions	P28827	Gene names	PTPRM, PTPRL1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PTPRM_MOUSE
NC score	0.009818 (rank : 76)	θ value	2.36792 (rank : 32)
Query Neighborhood Hits	56	Target Neighborhood Hits	238	Shared Neighborhood Hits	7
SwissProt Accessions	P28828	Gene names	Ptprm
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase mu precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase mu) (R-PTP-mu).

PTPRK_MOUSE
NC score	0.009428 (rank : 77)	θ value	5.27518 (rank : 41)
Query Neighborhood Hits	56	Target Neighborhood Hits	223	Shared Neighborhood Hits	6
SwissProt Accessions	P35822	Gene names	Ptprk, Ptpk
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

PTPRK_HUMAN
NC score	0.009345 (rank : 78)	θ value	5.27518 (rank : 40)
Query Neighborhood Hits	56	Target Neighborhood Hits	228	Shared Neighborhood Hits	6
SwissProt Accessions	Q15262, Q14763	Gene names	PTPRK, PTPK
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase kappa precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase kappa) (R-PTP-kappa).

SYT1_HUMAN
NC score	0.009188 (rank : 79)	θ value	1.81305 (rank : 29)
Query Neighborhood Hits	56	Target Neighborhood Hits	150	Shared Neighborhood Hits	6
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
NC score	0.009128 (rank : 80)	θ value	1.81305 (rank : 30)
Query Neighborhood Hits	56	Target Neighborhood Hits	150	Shared Neighborhood Hits	5
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

IGF2_HUMAN
NC score	0.008489 (rank : 81)	θ value	8.99809 (rank : 50)
Query Neighborhood Hits	56	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	P01344, P78449, Q14299, Q9UC68, Q9UC69	Gene names	IGF2
Domain Architecture
Description	Insulin-like growth factor II precursor (IGF-II) (Somatomedin A) [Contains: Insulin-like growth factor II Ala-25 Del].

RENT1_HUMAN
NC score	0.008109 (rank : 82)	θ value	4.03905 (rank : 37)
Query Neighborhood Hits	56	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	Q92900, O00239, O43343, Q86Z25, Q92842	Gene names	UPF1, KIAA0221, RENT1
Domain Architecture
Description	Regulator of nonsense transcripts 1 (EC 3.6.1.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up- frameshift suppressor 1 homolog) (hUpf1).

OTU7A_HUMAN
NC score	0.008070 (rank : 83)	θ value	5.27518 (rank : 39)
Query Neighborhood Hits	56	Target Neighborhood Hits	74	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TE49, Q8IWK5	Gene names	OTUD7A, C15orf16, OTUD7
Domain Architecture	No domain graphic available
Description	OTU domain-containing protein 7A (EC 3.-.-.-) (Zinc finger protein Cezanne 2).

ZN346_MOUSE
NC score	0.007489 (rank : 84)	θ value	8.99809 (rank : 56)
Query Neighborhood Hits	56	Target Neighborhood Hits	93	Shared Neighborhood Hits	2
SwissProt Accessions	Q9R0B7	Gene names	Znf346, Jaz, Zfp346
Domain Architecture	No domain graphic available
Description	Zinc finger protein 346 (Just another zinc finger protein).

SYT2_HUMAN
NC score	0.006698 (rank : 85)	θ value	8.99809 (rank : 53)
Query Neighborhood Hits	56	Target Neighborhood Hits	142	Shared Neighborhood Hits	5
SwissProt Accessions	Q8N9I0, Q496K5, Q8NBE5	Gene names	SYT2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT2_MOUSE
NC score	0.006678 (rank : 86)	θ value	8.99809 (rank : 54)
Query Neighborhood Hits	56	Target Neighborhood Hits	143	Shared Neighborhood Hits	5
SwissProt Accessions	P46097, Q8R0E1	Gene names	Syt2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

TRPC6_MOUSE
NC score	0.006549 (rank : 87)	θ value	5.27518 (rank : 44)
Query Neighborhood Hits	56	Target Neighborhood Hits	171	Shared Neighborhood Hits	3
SwissProt Accessions	Q61143, Q9Z2J1	Gene names	Trpc6, Trp6, Trrp6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6) (Calcium entry channel).

TRPC6_HUMAN
NC score	0.006453 (rank : 88)	θ value	5.27518 (rank : 43)
Query Neighborhood Hits	56	Target Neighborhood Hits	171	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y210, Q9HCW3, Q9NQA8, Q9NQA9	Gene names	TRPC6, TRP6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6).

SPB6_HUMAN
NC score	0.005963 (rank : 89)	θ value	0.62314 (rank : 24)
Query Neighborhood Hits	56	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	P35237, Q96J44	Gene names	SERPINB6, PI6, PTI
Domain Architecture
Description	Serpin B6 (Placental thrombin inhibitor) (Cytoplasmic antiproteinase) (CAP) (Protease inhibitor 6) (PI-6).

STAR8_HUMAN
NC score	0.005893 (rank : 90)	θ value	4.03905 (rank : 38)
Query Neighborhood Hits	56	Target Neighborhood Hits	216	Shared Neighborhood Hits	2
SwissProt Accessions	Q92502, Q5JST0	Gene names	STARD8, KIAA0189
Domain Architecture
Description	StAR-related lipid transfer protein 8 (StARD8) (START domain- containing protein 8).

MEF2A_HUMAN
NC score	0.005061 (rank : 91)	θ value	8.99809 (rank : 51)
Query Neighborhood Hits	56	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	Q02078, O43814, Q14223, Q14224, Q96D14	Gene names	MEF2A, MEF2
Domain Architecture
Description	Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1).

MMP25_HUMAN
NC score	0.003954 (rank : 92)	θ value	4.03905 (rank : 34)
Query Neighborhood Hits	56	Target Neighborhood Hits	56	Shared Neighborhood Hits	2
SwissProt Accessions	Q9NPA2, Q9H3Q0	Gene names	MMP25, MT6MMP
Domain Architecture
Description	Matrix metalloproteinase-25 precursor (EC 3.4.24.-) (MMP-25) (Membrane-type matrix metalloproteinase 6) (MT-MMP 6) (Membrane-type-6 matrix metalloproteinase) (MT6-MMP) (Leukolysin).

CO7A1_HUMAN
NC score	0.000594 (rank : 93)	θ value	8.99809 (rank : 48)
Query Neighborhood Hits	56	Target Neighborhood Hits	807	Shared Neighborhood Hits	6
SwissProt Accessions	Q02388, Q14054, Q16507	Gene names	COL7A1
Domain Architecture
Description	Collagen alpha-1(VII) chain precursor (Long-chain collagen) (LC collagen).

AAK1_MOUSE
NC score	-0.000271 (rank : 94)	θ value	6.88961 (rank : 45)
Query Neighborhood Hits	56	Target Neighborhood Hits	1051	Shared Neighborhood Hits	3
SwissProt Accessions	Q3UHJ0, Q3TY53, Q6ZPZ6, Q80XP6	Gene names	Aak1, Kiaa1048
Domain Architecture	No domain graphic available
Description	AP2-associated protein kinase 1 (EC 2.7.11.1) (Adaptor-associated kinase 1).

GPR87_HUMAN
NC score	-0.001064 (rank : 95)	θ value	8.99809 (rank : 49)
Query Neighborhood Hits	56	Target Neighborhood Hits	591	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BY21, Q96JZ8, Q9BXC2	Gene names	GPR87, GPR95
Domain Architecture
Description	Probable G-protein coupled receptor 87 (G-protein coupled receptor 95).

ZNF38_HUMAN
NC score	-0.001422 (rank : 96)	θ value	1.81305 (rank : 31)
Query Neighborhood Hits	56	Target Neighborhood Hits	742	Shared Neighborhood Hits	3
SwissProt Accessions	P17036, P13683, Q9NNX8, Q9NXJ1, Q9UC15, Q9UC16	Gene names	ZNF38, KOX25, ZNF3
Domain Architecture
Description	Zinc finger protein 38 (Zinc finger protein KOX25) (Zinc finger protein HF.12) (Zinc finger protein 3) (HZF3.1).