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Network neighborhood for query Sequence : NAC3_HUMAN

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NAC3_HUMAN
SwissProt Accessions	P57103, Q8IUE9, Q8IUF0, Q8NFI7	Gene names	SLC8A3, NCX3
Domain Architecture
Description	Sodium/calcium exchanger 3 precursor (Na(+)/Ca(2+)-exchange protein 3).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NAC1_HUMAN
θ value	0 (rank : 1)	NC score	0.993816 (rank : 3)
Query Neighborhood Hits	42	Target Neighborhood Hits	43	Shared Neighborhood Hits	27
SwissProt Accessions	P32418, O95849, Q9UBL8, Q9UDN1, Q9UDN2, Q9UKX6	Gene names	SLC8A1, CNC, NCX1
Domain Architecture
Description	Sodium/calcium exchanger 1 precursor (Na(+)/Ca(2+)-exchange protein 1).

NAC1_MOUSE
θ value	0 (rank : 2)	NC score	0.993498 (rank : 4)
Query Neighborhood Hits	42	Target Neighborhood Hits	41	Shared Neighborhood Hits	25
SwissProt Accessions	P70414	Gene names	Slc8a1, Ncx
Domain Architecture
Description	Sodium/calcium exchanger 1 precursor (Na(+)/Ca(2+)-exchange protein 1).

NAC2_HUMAN
θ value	0 (rank : 3)	NC score	0.995799 (rank : 2)
Query Neighborhood Hits	42	Target Neighborhood Hits	33	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UPR5	Gene names	SLC8A2, KIAA1087, NCX2
Domain Architecture
Description	Sodium/calcium exchanger 2 precursor (Na(+)/Ca(2+)-exchange protein 2).

NAC3_HUMAN
θ value	0 (rank : 4)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	42
SwissProt Accessions	P57103, Q8IUE9, Q8IUF0, Q8NFI7	Gene names	SLC8A3, NCX3
Domain Architecture
Description	Sodium/calcium exchanger 3 precursor (Na(+)/Ca(2+)-exchange protein 3).

GPR98_HUMAN
θ value	1.68911e-14 (rank : 5)	NC score	0.345197 (rank : 17)
Query Neighborhood Hits	42	Target Neighborhood Hits	202	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WXG9, O75171, Q9H0X5, Q9UL61	Gene names	GPR98, KIAA0686, MASS1, VLGR1
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor 98 precursor (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Very large G-protein coupled receptor 1) (Usher syndrome type-2C protein).

FREM3_MOUSE
θ value	1.58096e-12 (rank : 6)	NC score	0.376838 (rank : 13)
Query Neighborhood Hits	42	Target Neighborhood Hits	49	Shared Neighborhood Hits	15
SwissProt Accessions	Q5H8B9	Gene names	Frem3, Nv2
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 3 precursor (NV domain- containing protein 2).

NCKX2_HUMAN
θ value	1.33837e-11 (rank : 7)	NC score	0.457641 (rank : 6)
Query Neighborhood Hits	42	Target Neighborhood Hits	34	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UI40, Q9NTN5, Q9NZQ4	Gene names	SLC24A2, NCKX2
Domain Architecture
Description	Sodium/potassium/calcium exchanger 2 precursor (Na(+)/K(+)/Ca(2+)- exchange protein 2) (Retinal cone Na-Ca+K exchanger) (Solute carrier family 24 member 2).

GPR98_MOUSE
θ value	1.74796e-11 (rank : 8)	NC score	0.340583 (rank : 18)
Query Neighborhood Hits	42	Target Neighborhood Hits	206	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VHN7, Q6ZQ69, Q810D2, Q810D3, Q91ZS0, Q91ZS1	Gene names	Gpr98, Kiaa0686, Mass1, Vlgr1
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor 98 precursor (Monogenic audiogenic seizure susceptibility protein 1) (Very large G-protein coupled receptor 1) (Neurepin).

FREM2_HUMAN
θ value	1.9326e-10 (rank : 9)	NC score	0.369146 (rank : 16)
Query Neighborhood Hits	42	Target Neighborhood Hits	76	Shared Neighborhood Hits	15
SwissProt Accessions	Q5SZK8, Q4QQG1, Q5H9N8, Q5T6Q1, Q6N057, Q6ZSB4, Q7Z305, Q7Z341	Gene names	FREM2
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 2 precursor (ECM3 homolog).

NCKX5_HUMAN
θ value	3.29651e-10 (rank : 10)	NC score	0.459936 (rank : 5)
Query Neighborhood Hits	42	Target Neighborhood Hits	16	Shared Neighborhood Hits	14
SwissProt Accessions	Q71RS6, Q6DKH3	Gene names	SLC24A5, JSX, NCKX5
Domain Architecture	No domain graphic available
Description	Sodium/potassium/calcium exchanger 5 precursor (Na(+)/K(+)/Ca(2+)- exchange protein 5) (Solute carrier family 24 member 5).

FREM2_MOUSE
θ value	5.62301e-10 (rank : 11)	NC score	0.373276 (rank : 14)
Query Neighborhood Hits	42	Target Neighborhood Hits	73	Shared Neighborhood Hits	15
SwissProt Accessions	Q6NVD0, Q4W2Q5, Q5H8C0, Q811G9, Q8C4G5, Q8CD46	Gene names	Frem2, Nv1
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 2 precursor (ECM3 homolog) (NV domain-containing protein 1).

NCKX4_MOUSE
θ value	7.34386e-10 (rank : 12)	NC score	0.431655 (rank : 10)
Query Neighborhood Hits	42	Target Neighborhood Hits	22	Shared Neighborhood Hits	14
SwissProt Accessions	Q8CGQ8, Q8BLL5, Q8BLL7	Gene names	Slc24a4, Nckx4
Domain Architecture
Description	Sodium/potassium/calcium exchanger 4 precursor (Na(+)/K(+)/Ca(2+)- exchange protein 4).

FRAS1_MOUSE
θ value	9.59137e-10 (rank : 13)	NC score	0.260523 (rank : 19)
Query Neighborhood Hits	42	Target Neighborhood Hits	747	Shared Neighborhood Hits	18
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

NCKX4_HUMAN
θ value	9.59137e-10 (rank : 14)	NC score	0.432036 (rank : 9)
Query Neighborhood Hits	42	Target Neighborhood Hits	24	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NFF2, Q8N8U6, Q8NCX1, Q8NFF0, Q8NFF1	Gene names	SLC24A4, NCKX4
Domain Architecture
Description	Sodium/potassium/calcium exchanger 4 precursor (Na(+)/K(+)/Ca(2+)- exchange protein 4) (Solute carrier family 24 member 4).

FREM3_HUMAN
θ value	1.63604e-09 (rank : 15)	NC score	0.369406 (rank : 15)
Query Neighborhood Hits	42	Target Neighborhood Hits	56	Shared Neighborhood Hits	15
SwissProt Accessions	P0C091	Gene names	FREM3
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 3 precursor.

NCKX3_MOUSE
θ value	1.63604e-09 (rank : 16)	NC score	0.432537 (rank : 8)
Query Neighborhood Hits	42	Target Neighborhood Hits	30	Shared Neighborhood Hits	14
SwissProt Accessions	Q99PD7, Q99JR2, Q99PD8	Gene names	Slc24a3, Nckx3
Domain Architecture
Description	Sodium/potassium/calcium exchanger 3 precursor (Na(+)/K(+)/Ca(2+)- exchange protein 3).

NCKX3_HUMAN
θ value	2.13673e-09 (rank : 17)	NC score	0.430959 (rank : 11)
Query Neighborhood Hits	42	Target Neighborhood Hits	20	Shared Neighborhood Hits	14
SwissProt Accessions	Q9HC58, Q9BQJ9, Q9BQL7, Q9BQY3, Q9H519	Gene names	SLC24A3, NCKX3
Domain Architecture
Description	Sodium/potassium/calcium exchanger 3 precursor (Na(+)/K(+)/Ca(2+)- exchange protein 3) (Solute carrier family 24 member 3).

NCKX1_HUMAN
θ value	3.64472e-09 (rank : 18)	NC score	0.388356 (rank : 12)
Query Neighborhood Hits	42	Target Neighborhood Hits	223	Shared Neighborhood Hits	14
SwissProt Accessions	O60721, O43485, O75184	Gene names	SLC24A1, KIAA0702, NCKX1
Domain Architecture
Description	Sodium/potassium/calcium exchanger 1 (Na(+)/K(+)/Ca(2+)-exchange protein 1) (Retinal rod Na-Ca+K exchanger).

FRAS1_HUMAN
θ value	1.80886e-08 (rank : 19)	NC score	0.256239 (rank : 22)
Query Neighborhood Hits	42	Target Neighborhood Hits	759	Shared Neighborhood Hits	18
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

NCKX5_MOUSE
θ value	2.36244e-08 (rank : 20)	NC score	0.442976 (rank : 7)
Query Neighborhood Hits	42	Target Neighborhood Hits	15	Shared Neighborhood Hits	14
SwissProt Accessions	Q8C261, Q6XE39, Q8CJF1	Gene names	Slc24a5, Nckx5
Domain Architecture	No domain graphic available
Description	Sodium/potassium/calcium exchanger 5 precursor (Na(+)/K(+)/Ca(2+)- exchange protein 5) (Solute carrier family 24 member 5).

ITB4_HUMAN
θ value	1.69304e-06 (rank : 21)	NC score	0.114626 (rank : 27)
Query Neighborhood Hits	42	Target Neighborhood Hits	458	Shared Neighborhood Hits	17
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

FREM1_HUMAN
θ value	0.00298849 (rank : 22)	NC score	0.260416 (rank : 20)
Query Neighborhood Hits	42	Target Neighborhood Hits	170	Shared Neighborhood Hits	14
SwissProt Accessions	Q5H8C1, Q5VV00, Q5VV01, Q6MZI4, Q8NEG9, Q96LI3	Gene names	FREM1, C9orf154
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 1 precursor (Protein QBRICK).

FREM1_MOUSE
θ value	0.00509761 (rank : 23)	NC score	0.256607 (rank : 21)
Query Neighborhood Hits	42	Target Neighborhood Hits	163	Shared Neighborhood Hits	14
SwissProt Accessions	Q684R7, Q5H8C2, Q5M7B3, Q8C732	Gene names	Frem1
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 1 precursor (Protein QBRICK).

NCKX6_HUMAN
θ value	0.365318 (rank : 24)	NC score	0.214817 (rank : 23)
Query Neighborhood Hits	42	Target Neighborhood Hits	20	Shared Neighborhood Hits	14
SwissProt Accessions	Q6J4K2, Q4KMS9, Q6J4K1, Q9H6I8	Gene names	SLC24A6, NCKX6, NCLX
Domain Architecture	No domain graphic available
Description	Sodium/potassium/calcium exchanger 6 precursor (Na(+)/K(+)/Ca(2+)- exchange protein 6) (Solute carrier family 24 member 6).

SKIL_MOUSE
θ value	0.47712 (rank : 25)	NC score	0.021089 (rank : 32)
Query Neighborhood Hits	42	Target Neighborhood Hits	719	Shared Neighborhood Hits	5
SwissProt Accessions	Q60665, Q60702, Q78E90, Q80VK5	Gene names	Skil, Skir, Sno
Domain Architecture
Description	Ski-like protein (Ski-related protein) (Ski-related oncogene).

GLE1_HUMAN
θ value	0.62314 (rank : 26)	NC score	0.032797 (rank : 28)
Query Neighborhood Hits	42	Target Neighborhood Hits	445	Shared Neighborhood Hits	6
SwissProt Accessions	Q53GS7, O75458, Q53GT9, Q5VVU1, Q8NCP6, Q9UFL6	Gene names	GLE1L, GLE1
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein) (hGLE1).

LRP1B_MOUSE
θ value	1.06291 (rank : 27)	NC score	0.016608 (rank : 36)
Query Neighborhood Hits	42	Target Neighborhood Hits	606	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

LRP1B_HUMAN
θ value	1.38821 (rank : 28)	NC score	0.016996 (rank : 35)
Query Neighborhood Hits	42	Target Neighborhood Hits	602	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

NCKX6_MOUSE
θ value	1.38821 (rank : 29)	NC score	0.211711 (rank : 24)
Query Neighborhood Hits	42	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	Q925Q3, Q3U067, Q80XM7	Gene names	Slc24a6, Nckx6
Domain Architecture	No domain graphic available
Description	Sodium/potassium/calcium exchanger 6 precursor (Na(+)/K(+)/Ca(2+)- exchange protein 6) (Solute carrier family 24 member 6).

PTPRZ_HUMAN
θ value	1.81305 (rank : 30)	NC score	0.007125 (rank : 38)
Query Neighborhood Hits	42	Target Neighborhood Hits	255	Shared Neighborhood Hits	3
SwissProt Accessions	P23471	Gene names	PTPRZ1, PTPRZ, PTPZ
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase zeta precursor (EC 3.1.3.48) (R-PTP-zeta).

CADH1_HUMAN
θ value	2.36792 (rank : 31)	NC score	0.003471 (rank : 41)
Query Neighborhood Hits	42	Target Neighborhood Hits	157	Shared Neighborhood Hits	2
SwissProt Accessions	P12830, Q13799, Q14216, Q15855, Q16194, Q4PJ14	Gene names	CDH1, CDHE, UVO
Domain Architecture
Description	Epithelial-cadherin precursor (E-cadherin) (Uvomorulin) (Cadherin-1) (CAM 120/80) (CD324 antigen) [Contains: E-Cad/CTF1; E-Cad/CTF2; E- Cad/CTF3].

GLE1_MOUSE
θ value	2.36792 (rank : 32)	NC score	0.028402 (rank : 29)
Query Neighborhood Hits	42	Target Neighborhood Hits	504	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R322, Q3TT10, Q3TU23, Q3UD65, Q8BT16, Q9D4A6	Gene names	Gle1l
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein).

NUP50_HUMAN
θ value	4.03905 (rank : 33)	NC score	0.025742 (rank : 30)
Query Neighborhood Hits	42	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UKX7, O75644, Q9NPM9, Q9NPR6, Q9P1K5	Gene names	NUP50, NPAP60L
Domain Architecture
Description	Nucleoporin 50 kDa (Nuclear pore-associated protein 60 kDa-like).

NUP50_MOUSE
θ value	4.03905 (rank : 34)	NC score	0.025725 (rank : 31)
Query Neighborhood Hits	42	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JIH2, Q9CU02, Q9JK85	Gene names	Nup50, Npap60
Domain Architecture
Description	Nucleoporin 50 kDa (Nuclear pore-associated protein 60 kDa-like).

PCNT_MOUSE
θ value	4.03905 (rank : 35)	NC score	0.004783 (rank : 40)
Query Neighborhood Hits	42	Target Neighborhood Hits	1207	Shared Neighborhood Hits	7
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

SKIL_HUMAN
θ value	4.03905 (rank : 36)	NC score	0.018892 (rank : 33)
Query Neighborhood Hits	42	Target Neighborhood Hits	460	Shared Neighborhood Hits	5
SwissProt Accessions	P12757, O00464, P12756, Q07501	Gene names	SKIL, SNO
Domain Architecture
Description	Ski-like protein (Ski-related protein) (Ski-related oncogene).

SREC_HUMAN
θ value	4.03905 (rank : 37)	NC score	0.017319 (rank : 34)
Query Neighborhood Hits	42	Target Neighborhood Hits	645	Shared Neighborhood Hits	7
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

OAS2_HUMAN
θ value	5.27518 (rank : 38)	NC score	0.011064 (rank : 37)
Query Neighborhood Hits	42	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	P29728, Q86XX8	Gene names	OAS2
Domain Architecture	No domain graphic available
Description	2'-5'-oligoadenylate synthetase 2 (EC 2.7.7.-) ((2-5')oligo(A) synthetase 2) (2-5A synthetase 2) (p69 OAS / p71 OAS) (p69OAS / p71OAS).

PDZD1_HUMAN
θ value	5.27518 (rank : 39)	NC score	0.006136 (rank : 39)
Query Neighborhood Hits	42	Target Neighborhood Hits	190	Shared Neighborhood Hits	2
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

CTRO_HUMAN
θ value	6.88961 (rank : 40)	NC score	-0.002070 (rank : 44)
Query Neighborhood Hits	42	Target Neighborhood Hits	2092	Shared Neighborhood Hits	9
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

M3K12_MOUSE
θ value	6.88961 (rank : 41)	NC score	-0.001229 (rank : 42)
Query Neighborhood Hits	42	Target Neighborhood Hits	957	Shared Neighborhood Hits	4
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_HUMAN
θ value	8.99809 (rank : 42)	NC score	-0.001428 (rank : 43)
Query Neighborhood Hits	42	Target Neighborhood Hits	940	Shared Neighborhood Hits	4
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

CSPG4_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.134965 (rank : 25)
Query Neighborhood Hits	42	Target Neighborhood Hits	112	Shared Neighborhood Hits	9
SwissProt Accessions	Q6UVK1, Q92675	Gene names	CSPG4, MCSP
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 4 precursor (Chondroitin sulfate proteoglycan NG2) (Melanoma chondroitin sulfate proteoglycan) (Melanoma-associated chondroitin sulfate proteoglycan).

CSPG4_MOUSE
θ value	θ > 10 (rank : 44)	NC score	0.131723 (rank : 26)
Query Neighborhood Hits	42	Target Neighborhood Hits	105	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VHY0, Q5DTG1, Q8BPI8, Q8CE79	Gene names	Cspg4, An2, Kiaa4232, Ng2
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 4 precursor (Chondroitin sulfate proteoglycan NG2) (AN2 proteoglycan).

Hits sorted by NC score

NAC3_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 4)
Query Neighborhood Hits	42	Target Neighborhood Hits	42	Shared Neighborhood Hits	42
SwissProt Accessions	P57103, Q8IUE9, Q8IUF0, Q8NFI7	Gene names	SLC8A3, NCX3
Domain Architecture
Description	Sodium/calcium exchanger 3 precursor (Na(+)/Ca(2+)-exchange protein 3).

NAC2_HUMAN
NC score	0.995799 (rank : 2)	θ value	0 (rank : 3)
Query Neighborhood Hits	42	Target Neighborhood Hits	33	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UPR5	Gene names	SLC8A2, KIAA1087, NCX2
Domain Architecture
Description	Sodium/calcium exchanger 2 precursor (Na(+)/Ca(2+)-exchange protein 2).

NAC1_HUMAN
NC score	0.993816 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	42	Target Neighborhood Hits	43	Shared Neighborhood Hits	27
SwissProt Accessions	P32418, O95849, Q9UBL8, Q9UDN1, Q9UDN2, Q9UKX6	Gene names	SLC8A1, CNC, NCX1
Domain Architecture
Description	Sodium/calcium exchanger 1 precursor (Na(+)/Ca(2+)-exchange protein 1).

NAC1_MOUSE
NC score	0.993498 (rank : 4)	θ value	0 (rank : 2)
Query Neighborhood Hits	42	Target Neighborhood Hits	41	Shared Neighborhood Hits	25
SwissProt Accessions	P70414	Gene names	Slc8a1, Ncx
Domain Architecture
Description	Sodium/calcium exchanger 1 precursor (Na(+)/Ca(2+)-exchange protein 1).

NCKX5_HUMAN
NC score	0.459936 (rank : 5)	θ value	3.29651e-10 (rank : 10)
Query Neighborhood Hits	42	Target Neighborhood Hits	16	Shared Neighborhood Hits	14
SwissProt Accessions	Q71RS6, Q6DKH3	Gene names	SLC24A5, JSX, NCKX5
Domain Architecture	No domain graphic available
Description	Sodium/potassium/calcium exchanger 5 precursor (Na(+)/K(+)/Ca(2+)- exchange protein 5) (Solute carrier family 24 member 5).

NCKX2_HUMAN
NC score	0.457641 (rank : 6)	θ value	1.33837e-11 (rank : 7)
Query Neighborhood Hits	42	Target Neighborhood Hits	34	Shared Neighborhood Hits	14
SwissProt Accessions	Q9UI40, Q9NTN5, Q9NZQ4	Gene names	SLC24A2, NCKX2
Domain Architecture
Description	Sodium/potassium/calcium exchanger 2 precursor (Na(+)/K(+)/Ca(2+)- exchange protein 2) (Retinal cone Na-Ca+K exchanger) (Solute carrier family 24 member 2).

NCKX5_MOUSE
NC score	0.442976 (rank : 7)	θ value	2.36244e-08 (rank : 20)
Query Neighborhood Hits	42	Target Neighborhood Hits	15	Shared Neighborhood Hits	14
SwissProt Accessions	Q8C261, Q6XE39, Q8CJF1	Gene names	Slc24a5, Nckx5
Domain Architecture	No domain graphic available
Description	Sodium/potassium/calcium exchanger 5 precursor (Na(+)/K(+)/Ca(2+)- exchange protein 5) (Solute carrier family 24 member 5).

NCKX3_MOUSE
NC score	0.432537 (rank : 8)	θ value	1.63604e-09 (rank : 16)
Query Neighborhood Hits	42	Target Neighborhood Hits	30	Shared Neighborhood Hits	14
SwissProt Accessions	Q99PD7, Q99JR2, Q99PD8	Gene names	Slc24a3, Nckx3
Domain Architecture
Description	Sodium/potassium/calcium exchanger 3 precursor (Na(+)/K(+)/Ca(2+)- exchange protein 3).

NCKX4_HUMAN
NC score	0.432036 (rank : 9)	θ value	9.59137e-10 (rank : 14)
Query Neighborhood Hits	42	Target Neighborhood Hits	24	Shared Neighborhood Hits	14
SwissProt Accessions	Q8NFF2, Q8N8U6, Q8NCX1, Q8NFF0, Q8NFF1	Gene names	SLC24A4, NCKX4
Domain Architecture
Description	Sodium/potassium/calcium exchanger 4 precursor (Na(+)/K(+)/Ca(2+)- exchange protein 4) (Solute carrier family 24 member 4).

NCKX4_MOUSE
NC score	0.431655 (rank : 10)	θ value	7.34386e-10 (rank : 12)
Query Neighborhood Hits	42	Target Neighborhood Hits	22	Shared Neighborhood Hits	14
SwissProt Accessions	Q8CGQ8, Q8BLL5, Q8BLL7	Gene names	Slc24a4, Nckx4
Domain Architecture
Description	Sodium/potassium/calcium exchanger 4 precursor (Na(+)/K(+)/Ca(2+)- exchange protein 4).

NCKX3_HUMAN
NC score	0.430959 (rank : 11)	θ value	2.13673e-09 (rank : 17)
Query Neighborhood Hits	42	Target Neighborhood Hits	20	Shared Neighborhood Hits	14
SwissProt Accessions	Q9HC58, Q9BQJ9, Q9BQL7, Q9BQY3, Q9H519	Gene names	SLC24A3, NCKX3
Domain Architecture
Description	Sodium/potassium/calcium exchanger 3 precursor (Na(+)/K(+)/Ca(2+)- exchange protein 3) (Solute carrier family 24 member 3).

NCKX1_HUMAN
NC score	0.388356 (rank : 12)	θ value	3.64472e-09 (rank : 18)
Query Neighborhood Hits	42	Target Neighborhood Hits	223	Shared Neighborhood Hits	14
SwissProt Accessions	O60721, O43485, O75184	Gene names	SLC24A1, KIAA0702, NCKX1
Domain Architecture
Description	Sodium/potassium/calcium exchanger 1 (Na(+)/K(+)/Ca(2+)-exchange protein 1) (Retinal rod Na-Ca+K exchanger).

FREM3_MOUSE
NC score	0.376838 (rank : 13)	θ value	1.58096e-12 (rank : 6)
Query Neighborhood Hits	42	Target Neighborhood Hits	49	Shared Neighborhood Hits	15
SwissProt Accessions	Q5H8B9	Gene names	Frem3, Nv2
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 3 precursor (NV domain- containing protein 2).

FREM2_MOUSE
NC score	0.373276 (rank : 14)	θ value	5.62301e-10 (rank : 11)
Query Neighborhood Hits	42	Target Neighborhood Hits	73	Shared Neighborhood Hits	15
SwissProt Accessions	Q6NVD0, Q4W2Q5, Q5H8C0, Q811G9, Q8C4G5, Q8CD46	Gene names	Frem2, Nv1
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 2 precursor (ECM3 homolog) (NV domain-containing protein 1).

FREM3_HUMAN
NC score	0.369406 (rank : 15)	θ value	1.63604e-09 (rank : 15)
Query Neighborhood Hits	42	Target Neighborhood Hits	56	Shared Neighborhood Hits	15
SwissProt Accessions	P0C091	Gene names	FREM3
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 3 precursor.

FREM2_HUMAN
NC score	0.369146 (rank : 16)	θ value	1.9326e-10 (rank : 9)
Query Neighborhood Hits	42	Target Neighborhood Hits	76	Shared Neighborhood Hits	15
SwissProt Accessions	Q5SZK8, Q4QQG1, Q5H9N8, Q5T6Q1, Q6N057, Q6ZSB4, Q7Z305, Q7Z341	Gene names	FREM2
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 2 precursor (ECM3 homolog).

GPR98_HUMAN
NC score	0.345197 (rank : 17)	θ value	1.68911e-14 (rank : 5)
Query Neighborhood Hits	42	Target Neighborhood Hits	202	Shared Neighborhood Hits	15
SwissProt Accessions	Q8WXG9, O75171, Q9H0X5, Q9UL61	Gene names	GPR98, KIAA0686, MASS1, VLGR1
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor 98 precursor (Monogenic audiogenic seizure susceptibility protein 1 homolog) (Very large G-protein coupled receptor 1) (Usher syndrome type-2C protein).

GPR98_MOUSE
NC score	0.340583 (rank : 18)	θ value	1.74796e-11 (rank : 8)
Query Neighborhood Hits	42	Target Neighborhood Hits	206	Shared Neighborhood Hits	15
SwissProt Accessions	Q8VHN7, Q6ZQ69, Q810D2, Q810D3, Q91ZS0, Q91ZS1	Gene names	Gpr98, Kiaa0686, Mass1, Vlgr1
Domain Architecture	No domain graphic available
Description	G-protein coupled receptor 98 precursor (Monogenic audiogenic seizure susceptibility protein 1) (Very large G-protein coupled receptor 1) (Neurepin).

FRAS1_MOUSE
NC score	0.260523 (rank : 19)	θ value	9.59137e-10 (rank : 13)
Query Neighborhood Hits	42	Target Neighborhood Hits	747	Shared Neighborhood Hits	18
SwissProt Accessions	Q80T14, Q80TC7, Q811H8, Q8BPZ4	Gene names	Fras1, Kiaa1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

FREM1_HUMAN
NC score	0.260416 (rank : 20)	θ value	0.00298849 (rank : 22)
Query Neighborhood Hits	42	Target Neighborhood Hits	170	Shared Neighborhood Hits	14
SwissProt Accessions	Q5H8C1, Q5VV00, Q5VV01, Q6MZI4, Q8NEG9, Q96LI3	Gene names	FREM1, C9orf154
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 1 precursor (Protein QBRICK).

FREM1_MOUSE
NC score	0.256607 (rank : 21)	θ value	0.00509761 (rank : 23)
Query Neighborhood Hits	42	Target Neighborhood Hits	163	Shared Neighborhood Hits	14
SwissProt Accessions	Q684R7, Q5H8C2, Q5M7B3, Q8C732	Gene names	Frem1
Domain Architecture	No domain graphic available
Description	FRAS1-related extracellular matrix protein 1 precursor (Protein QBRICK).

FRAS1_HUMAN
NC score	0.256239 (rank : 22)	θ value	1.80886e-08 (rank : 19)
Query Neighborhood Hits	42	Target Neighborhood Hits	759	Shared Neighborhood Hits	18
SwissProt Accessions	Q86XX4, Q86UZ4, Q8N3U9, Q8NAU7, Q96JW7, Q9H6N9, Q9P228	Gene names	FRAS1, KIAA1500
Domain Architecture	No domain graphic available
Description	Extracellular matrix protein FRAS1 precursor.

NCKX6_HUMAN
NC score	0.214817 (rank : 23)	θ value	0.365318 (rank : 24)
Query Neighborhood Hits	42	Target Neighborhood Hits	20	Shared Neighborhood Hits	14
SwissProt Accessions	Q6J4K2, Q4KMS9, Q6J4K1, Q9H6I8	Gene names	SLC24A6, NCKX6, NCLX
Domain Architecture	No domain graphic available
Description	Sodium/potassium/calcium exchanger 6 precursor (Na(+)/K(+)/Ca(2+)- exchange protein 6) (Solute carrier family 24 member 6).

NCKX6_MOUSE
NC score	0.211711 (rank : 24)	θ value	1.38821 (rank : 29)
Query Neighborhood Hits	42	Target Neighborhood Hits	18	Shared Neighborhood Hits	14
SwissProt Accessions	Q925Q3, Q3U067, Q80XM7	Gene names	Slc24a6, Nckx6
Domain Architecture	No domain graphic available
Description	Sodium/potassium/calcium exchanger 6 precursor (Na(+)/K(+)/Ca(2+)- exchange protein 6) (Solute carrier family 24 member 6).

CSPG4_HUMAN
NC score	0.134965 (rank : 25)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	42	Target Neighborhood Hits	112	Shared Neighborhood Hits	9
SwissProt Accessions	Q6UVK1, Q92675	Gene names	CSPG4, MCSP
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 4 precursor (Chondroitin sulfate proteoglycan NG2) (Melanoma chondroitin sulfate proteoglycan) (Melanoma-associated chondroitin sulfate proteoglycan).

CSPG4_MOUSE
NC score	0.131723 (rank : 26)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	42	Target Neighborhood Hits	105	Shared Neighborhood Hits	8
SwissProt Accessions	Q8VHY0, Q5DTG1, Q8BPI8, Q8CE79	Gene names	Cspg4, An2, Kiaa4232, Ng2
Domain Architecture	No domain graphic available
Description	Chondroitin sulfate proteoglycan 4 precursor (Chondroitin sulfate proteoglycan NG2) (AN2 proteoglycan).

ITB4_HUMAN
NC score	0.114626 (rank : 27)	θ value	1.69304e-06 (rank : 21)
Query Neighborhood Hits	42	Target Neighborhood Hits	458	Shared Neighborhood Hits	17
SwissProt Accessions	P16144, O14690, O14691, O15339, O15340, O15341, Q9UIQ4	Gene names	ITGB4
Domain Architecture
Description	Integrin beta-4 precursor (GP150) (CD104 antigen).

GLE1_HUMAN
NC score	0.032797 (rank : 28)	θ value	0.62314 (rank : 26)
Query Neighborhood Hits	42	Target Neighborhood Hits	445	Shared Neighborhood Hits	6
SwissProt Accessions	Q53GS7, O75458, Q53GT9, Q5VVU1, Q8NCP6, Q9UFL6	Gene names	GLE1L, GLE1
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein) (hGLE1).

GLE1_MOUSE
NC score	0.028402 (rank : 29)	θ value	2.36792 (rank : 32)
Query Neighborhood Hits	42	Target Neighborhood Hits	504	Shared Neighborhood Hits	6
SwissProt Accessions	Q8R322, Q3TT10, Q3TU23, Q3UD65, Q8BT16, Q9D4A6	Gene names	Gle1l
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein).

NUP50_HUMAN
NC score	0.025742 (rank : 30)	θ value	4.03905 (rank : 33)
Query Neighborhood Hits	42	Target Neighborhood Hits	17	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UKX7, O75644, Q9NPM9, Q9NPR6, Q9P1K5	Gene names	NUP50, NPAP60L
Domain Architecture
Description	Nucleoporin 50 kDa (Nuclear pore-associated protein 60 kDa-like).

NUP50_MOUSE
NC score	0.025725 (rank : 31)	θ value	4.03905 (rank : 34)
Query Neighborhood Hits	42	Target Neighborhood Hits	15	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JIH2, Q9CU02, Q9JK85	Gene names	Nup50, Npap60
Domain Architecture
Description	Nucleoporin 50 kDa (Nuclear pore-associated protein 60 kDa-like).

SKIL_MOUSE
NC score	0.021089 (rank : 32)	θ value	0.47712 (rank : 25)
Query Neighborhood Hits	42	Target Neighborhood Hits	719	Shared Neighborhood Hits	5
SwissProt Accessions	Q60665, Q60702, Q78E90, Q80VK5	Gene names	Skil, Skir, Sno
Domain Architecture
Description	Ski-like protein (Ski-related protein) (Ski-related oncogene).

SKIL_HUMAN
NC score	0.018892 (rank : 33)	θ value	4.03905 (rank : 36)
Query Neighborhood Hits	42	Target Neighborhood Hits	460	Shared Neighborhood Hits	5
SwissProt Accessions	P12757, O00464, P12756, Q07501	Gene names	SKIL, SNO
Domain Architecture
Description	Ski-like protein (Ski-related protein) (Ski-related oncogene).

SREC_HUMAN
NC score	0.017319 (rank : 34)	θ value	4.03905 (rank : 37)
Query Neighborhood Hits	42	Target Neighborhood Hits	645	Shared Neighborhood Hits	7
SwissProt Accessions	Q14162, O43701	Gene names	SCARF1, KIAA0149, SREC
Domain Architecture	No domain graphic available
Description	Endothelial cells scavenger receptor precursor (Acetyl LDL receptor) (Scavenger receptor class F member 1).

LRP1B_HUMAN
NC score	0.016996 (rank : 35)	θ value	1.38821 (rank : 28)
Query Neighborhood Hits	42	Target Neighborhood Hits	602	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NZR2, Q8WY29, Q8WY30, Q8WY31	Gene names	LRP1B, LRPDIT
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

LRP1B_MOUSE
NC score	0.016608 (rank : 36)	θ value	1.06291 (rank : 27)
Query Neighborhood Hits	42	Target Neighborhood Hits	606	Shared Neighborhood Hits	7
SwissProt Accessions	Q9JI18, Q8BZD3, Q8BZM7	Gene names	Lrp1b, Lrpdit
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 1B precursor (Low- density lipoprotein receptor-related protein-deleted in tumor) (LRP- DIT).

OAS2_HUMAN
NC score	0.011064 (rank : 37)	θ value	5.27518 (rank : 38)
Query Neighborhood Hits	42	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	P29728, Q86XX8	Gene names	OAS2
Domain Architecture	No domain graphic available
Description	2'-5'-oligoadenylate synthetase 2 (EC 2.7.7.-) ((2-5')oligo(A) synthetase 2) (2-5A synthetase 2) (p69 OAS / p71 OAS) (p69OAS / p71OAS).

PTPRZ_HUMAN
NC score	0.007125 (rank : 38)	θ value	1.81305 (rank : 30)
Query Neighborhood Hits	42	Target Neighborhood Hits	255	Shared Neighborhood Hits	3
SwissProt Accessions	P23471	Gene names	PTPRZ1, PTPRZ, PTPZ
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase zeta precursor (EC 3.1.3.48) (R-PTP-zeta).

PDZD1_HUMAN
NC score	0.006136 (rank : 39)	θ value	5.27518 (rank : 39)
Query Neighborhood Hits	42	Target Neighborhood Hits	190	Shared Neighborhood Hits	2
SwissProt Accessions	Q5T2W1, O60450, Q5T5P6, Q9BQ41	Gene names	PDZK1, CAP70, NHERF3, PDZD1
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 1 (CFTR-associated protein of 70 kDa) (Na/Pi cotransporter C-terminal-associated protein) (NaPi-Cap1) (Na(+)/H(+) exchanger regulatory factor 3) (Sodium-hydrogen exchanger regulatory factor 3).

PCNT_MOUSE
NC score	0.004783 (rank : 40)	θ value	4.03905 (rank : 35)
Query Neighborhood Hits	42	Target Neighborhood Hits	1207	Shared Neighborhood Hits	7
SwissProt Accessions	P48725	Gene names	Pcnt, Pcnt2
Domain Architecture	No domain graphic available
Description	Pericentrin.

CADH1_HUMAN
NC score	0.003471 (rank : 41)	θ value	2.36792 (rank : 31)
Query Neighborhood Hits	42	Target Neighborhood Hits	157	Shared Neighborhood Hits	2
SwissProt Accessions	P12830, Q13799, Q14216, Q15855, Q16194, Q4PJ14	Gene names	CDH1, CDHE, UVO
Domain Architecture
Description	Epithelial-cadherin precursor (E-cadherin) (Uvomorulin) (Cadherin-1) (CAM 120/80) (CD324 antigen) [Contains: E-Cad/CTF1; E-Cad/CTF2; E- Cad/CTF3].

M3K12_MOUSE
NC score	-0.001229 (rank : 42)	θ value	6.88961 (rank : 41)
Query Neighborhood Hits	42	Target Neighborhood Hits	957	Shared Neighborhood Hits	4
SwissProt Accessions	Q60700, P70286, Q3TLL7, Q8C4N7, Q8CBX3, Q8CDL6	Gene names	Map3k12, Zpk
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

M3K12_HUMAN
NC score	-0.001428 (rank : 43)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	42	Target Neighborhood Hits	940	Shared Neighborhood Hits	4
SwissProt Accessions	Q12852, Q86VQ5, Q8WY25	Gene names	MAP3K12, ZPK
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Mixed lineage kinase) (Leucine-zipper protein kinase) (ZPK) (Dual leucine zipper bearing kinase) (DLK) (MAPK-upstream kinase) (MUK).

CTRO_HUMAN
NC score	-0.002070 (rank : 44)	θ value	6.88961 (rank : 40)
Query Neighborhood Hits	42	Target Neighborhood Hits	2092	Shared Neighborhood Hits	9
SwissProt Accessions	O14578, Q6XUH8, Q86UQ9, Q9UPZ7	Gene names	CIT, KIAA0949, STK21
Domain Architecture	No domain graphic available
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).