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Network neighborhood for query Sequence : AQR_MOUSE

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AQR_MOUSE
SwissProt Accessions	Q8CFQ3, P97871, Q3U9N1, Q3ULE8, Q80TX8	Gene names	Aqr, Kiaa0560
Domain Architecture	No domain graphic available
Description	Intron-binding protein aquarius.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

AQR_HUMAN
θ value	0 (rank : 1)	NC score	0.991481 (rank : 2)
Query Neighborhood Hits	62	Target Neighborhood Hits	88	Shared Neighborhood Hits	46
SwissProt Accessions	O60306, Q2YDX9, Q6IRU8, Q6PIC8	Gene names	AQR, KIAA0560
Domain Architecture	No domain graphic available
Description	Intron-binding protein aquarius (Intron-binding protein of 160 kDa) (IBP160).

AQR_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	62	Target Neighborhood Hits	62	Shared Neighborhood Hits	62
SwissProt Accessions	Q8CFQ3, P97871, Q3U9N1, Q3ULE8, Q80TX8	Gene names	Aqr, Kiaa0560
Domain Architecture	No domain graphic available
Description	Intron-binding protein aquarius.

ZNFX1_MOUSE
θ value	1.73987e-27 (rank : 3)	NC score	0.518756 (rank : 6)
Query Neighborhood Hits	62	Target Neighborhood Hits	407	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R151, Q3U016, Q3UD71, Q3UEZ0	Gene names	ZNFX1
Domain Architecture	No domain graphic available
Description	NFX1-type zinc finger-containing protein 1.

ZNFX1_HUMAN
θ value	2.27234e-27 (rank : 4)	NC score	0.521767 (rank : 5)
Query Neighborhood Hits	62	Target Neighborhood Hits	308	Shared Neighborhood Hits	20
SwissProt Accessions	Q9P2E3, Q9BQM7, Q9BQM8, Q9H8C1, Q9H9S2, Q9NUM1, Q9NWW1	Gene names	ZNFX1, KIAA1404
Domain Architecture	No domain graphic available
Description	NFX1-type zinc finger-containing protein 1.

RENT1_HUMAN
θ value	2.97466e-19 (rank : 5)	NC score	0.574432 (rank : 3)
Query Neighborhood Hits	62	Target Neighborhood Hits	51	Shared Neighborhood Hits	17
SwissProt Accessions	Q92900, O00239, O43343, Q86Z25, Q92842	Gene names	UPF1, KIAA0221, RENT1
Domain Architecture
Description	Regulator of nonsense transcripts 1 (EC 3.6.1.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up- frameshift suppressor 1 homolog) (hUpf1).

RENT1_MOUSE
θ value	2.97466e-19 (rank : 6)	NC score	0.574237 (rank : 4)
Query Neighborhood Hits	62	Target Neighborhood Hits	54	Shared Neighborhood Hits	17
SwissProt Accessions	Q9EPU0, Q99PR4	Gene names	Upf1, Rent1
Domain Architecture
Description	Regulator of nonsense transcripts 1 (EC 3.6.1.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up- frameshift suppressor 1 homolog) (mUpf1).

SETX_HUMAN
θ value	9.90251e-15 (rank : 7)	NC score	0.509041 (rank : 7)
Query Neighborhood Hits	62	Target Neighborhood Hits	368	Shared Neighborhood Hits	21
SwissProt Accessions	Q7Z333, O75120, Q3KQX4, Q68DW5, Q6AZD7, Q7Z3J6, Q8WX33, Q9H9D1, Q9NVP9	Gene names	SETX, ALS4, KIAA0625, SCAR1
Domain Architecture
Description	Probable helicase senataxin (EC 3.6.1.-) (SEN1 homolog).

SMBP2_MOUSE
θ value	5.62301e-10 (rank : 8)	NC score	0.486195 (rank : 8)
Query Neighborhood Hits	62	Target Neighborhood Hits	104	Shared Neighborhood Hits	17
SwissProt Accessions	P40694	Gene names	Ighmbp2, Smbp-2, Smbp2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Cardiac transcription factor 1) (CATF1).

SMBP2_HUMAN
θ value	2.13673e-09 (rank : 9)	NC score	0.481119 (rank : 9)
Query Neighborhood Hits	62	Target Neighborhood Hits	107	Shared Neighborhood Hits	17
SwissProt Accessions	P38935, Q00443, Q14177	Gene names	IGHMBP2, SMBP2, SMUBP2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Glial factor 1) (GF-1).

PR285_HUMAN
θ value	1.06045e-08 (rank : 10)	NC score	0.443960 (rank : 10)
Query Neighborhood Hits	62	Target Neighborhood Hits	63	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BYK8, Q3C2G2, Q4VXQ1, Q8TEF3, Q96ND3, Q9C094	Gene names	PRIC285, KIAA1769
Domain Architecture
Description	Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein (EC 3.6.1.-) (ATP-dependent helicase PRIC285) (PPAR-alpha- interacting complex protein 285) (PPAR-gamma DBD-interacting protein 1) (PDIP1).

M10L1_HUMAN
θ value	2.88788e-06 (rank : 11)	NC score	0.389054 (rank : 11)
Query Neighborhood Hits	62	Target Neighborhood Hits	36	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BXT6, Q5TGD5, Q8NBD4, Q9NXW3, Q9UFB3, Q9UGX9	Gene names	MOV10L1
Domain Architecture
Description	Putative helicase Mov10l1 (EC 3.6.1.-) (Moloney leukemia virus 10-like protein 1) (MOV10-like 1).

M10L1_MOUSE
θ value	4.1701e-05 (rank : 12)	NC score	0.374327 (rank : 12)
Query Neighborhood Hits	62	Target Neighborhood Hits	59	Shared Neighborhood Hits	15
SwissProt Accessions	Q99MV5, Q7TPA9, Q8C3W0, Q924C2	Gene names	Mov10l1, Champ
Domain Architecture
Description	Putative helicase Mov10l1 (EC 3.6.1.-) (Moloney leukemia virus 10-like protein 1) (MOV10-like 1) (Cardiac helicase activated by MEF2 protein) (Cardiac-specific RNA helicase).

HELZ_HUMAN
θ value	0.00390308 (rank : 13)	NC score	0.339732 (rank : 15)
Query Neighborhood Hits	62	Target Neighborhood Hits	198	Shared Neighborhood Hits	18
SwissProt Accessions	P42694	Gene names	HELZ, KIAA0054
Domain Architecture	No domain graphic available
Description	Probable helicase with zinc-finger domain (EC 3.6.1.-).

MOV10_HUMAN
θ value	0.00509761 (rank : 14)	NC score	0.349095 (rank : 13)
Query Neighborhood Hits	62	Target Neighborhood Hits	46	Shared Neighborhood Hits	17
SwissProt Accessions	Q9HCE1, Q8TEF0, Q9BSY3, Q9BUJ9	Gene names	MOV10, KIAA1631
Domain Architecture
Description	Putative helicase MOV-10 (EC 3.6.1.-) (Moloney leukemia virus 10 protein).

MOV10_MOUSE
θ value	0.0252991 (rank : 15)	NC score	0.341974 (rank : 14)
Query Neighborhood Hits	62	Target Neighborhood Hits	39	Shared Neighborhood Hits	17
SwissProt Accessions	P23249, Q9DC64	Gene names	Mov10, Gb110
Domain Architecture
Description	Putative helicase MOV-10 (EC 3.6.1.-) (Moloney leukemia virus 10 protein).

RA51D_MOUSE
θ value	0.0563607 (rank : 16)	NC score	0.111155 (rank : 16)
Query Neighborhood Hits	62	Target Neighborhood Hits	18	Shared Neighborhood Hits	4
SwissProt Accessions	O55230	Gene names	Rad51l3, R51h3, Rad51d
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD51 homolog 4 (R51H3) (RAD51-like protein 3).

DDX58_MOUSE
θ value	0.163984 (rank : 17)	NC score	0.057684 (rank : 33)
Query Neighborhood Hits	62	Target Neighborhood Hits	99	Shared Neighborhood Hits	7
SwissProt Accessions	Q6Q899, Q8C320, Q8C5I3, Q8C7T2	Gene names	Ddx58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

RA51D_HUMAN
θ value	0.21417 (rank : 18)	NC score	0.097167 (rank : 17)
Query Neighborhood Hits	62	Target Neighborhood Hits	18	Shared Neighborhood Hits	4
SwissProt Accessions	O75771, O43537, O60355, O75196, O75847, O75848, O76073, O76085, O94908, Q9UFU5	Gene names	RAD51L3, RAD51D
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD51 homolog 4 (R51H3) (RAD51-like protein 3) (TRAD).

FANCM_HUMAN
θ value	0.365318 (rank : 19)	NC score	0.069223 (rank : 27)
Query Neighborhood Hits	62	Target Neighborhood Hits	210	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

FANCM_MOUSE
θ value	0.365318 (rank : 20)	NC score	0.067310 (rank : 29)
Query Neighborhood Hits	62	Target Neighborhood Hits	177	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BGE5, Q69ZF5, Q8BKB7, Q8BUA8	Gene names	Fancm, Kiaa1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM).

NVL_HUMAN
θ value	0.62314 (rank : 21)	NC score	0.045391 (rank : 43)
Query Neighborhood Hits	62	Target Neighborhood Hits	112	Shared Neighborhood Hits	14
SwissProt Accessions	O15381, Q96EM7	Gene names	NVL
Domain Architecture
Description	Nuclear valosin-containing protein-like (Nuclear VCP-like protein) (NVLp).

NVL_MOUSE
θ value	0.62314 (rank : 22)	NC score	0.044950 (rank : 44)
Query Neighborhood Hits	62	Target Neighborhood Hits	110	Shared Neighborhood Hits	12
SwissProt Accessions	Q9DBY8, Q3USC4, Q8BW27, Q8K2B5	Gene names	Nvl
Domain Architecture
Description	Nuclear valosin-containing protein-like (Nuclear VCP-like protein) (NVLp).

KI67_HUMAN
θ value	0.813845 (rank : 23)	NC score	0.032876 (rank : 53)
Query Neighborhood Hits	62	Target Neighborhood Hits	581	Shared Neighborhood Hits	7
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

PARP2_MOUSE
θ value	0.813845 (rank : 24)	NC score	0.026820 (rank : 57)
Query Neighborhood Hits	62	Target Neighborhood Hits	53	Shared Neighborhood Hits	2
SwissProt Accessions	O88554, Q99N29	Gene names	Parp2, Adprt2, Adprtl2, Aspartl2
Domain Architecture
Description	Poly [ADP-ribose] polymerase 2 (EC 2.4.2.30) (PARP-2) (NAD(+) ADP- ribosyltransferase 2) (Poly[ADP-ribose] synthetase 2) (pADPRT-2) (mPARP-2).

GLI2_HUMAN
θ value	1.06291 (rank : 25)	NC score	0.007242 (rank : 72)
Query Neighborhood Hits	62	Target Neighborhood Hits	971	Shared Neighborhood Hits	4
SwissProt Accessions	P10070, O60252, O60253, O60254, O60255, Q15590, Q15591	Gene names	GLI2, THP
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI2 (Tax helper protein).

CCD27_HUMAN
θ value	1.38821 (rank : 26)	NC score	0.038836 (rank : 48)
Query Neighborhood Hits	62	Target Neighborhood Hits	594	Shared Neighborhood Hits	6
SwissProt Accessions	Q2M243, Q5TBV3, Q96M50	Gene names	CCDC27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

NAL10_MOUSE
θ value	1.38821 (rank : 27)	NC score	0.027885 (rank : 56)
Query Neighborhood Hits	62	Target Neighborhood Hits	46	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CCN1	Gene names	Nalp10, Pynod
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10.

MRCKB_HUMAN
θ value	1.81305 (rank : 28)	NC score	0.004996 (rank : 77)
Query Neighborhood Hits	62	Target Neighborhood Hits	2239	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

PEX6_HUMAN
θ value	1.81305 (rank : 29)	NC score	0.045938 (rank : 42)
Query Neighborhood Hits	62	Target Neighborhood Hits	99	Shared Neighborhood Hits	19
SwissProt Accessions	Q13608, Q8WYQ2, Q99476	Gene names	PEX6, PXAAA1
Domain Architecture
Description	Peroxisome assembly factor 2 (PAF-2) (Peroxisomal-type ATPase 1) (Peroxin-6) (Peroxisomal biogenesis factor 6).

PEX6_MOUSE
θ value	1.81305 (rank : 30)	NC score	0.046830 (rank : 41)
Query Neighborhood Hits	62	Target Neighborhood Hits	94	Shared Neighborhood Hits	15
SwissProt Accessions	Q99LC9, Q6YNQ9	Gene names	Pex6
Domain Architecture	No domain graphic available
Description	Peroxisome assembly factor 2 (PAF-2) (Peroxisomal-type ATPase 1) (Peroxin-6) (Peroxisomal biogenesis factor 6).

FBX18_HUMAN
θ value	2.36792 (rank : 31)	NC score	0.044530 (rank : 45)
Query Neighborhood Hits	62	Target Neighborhood Hits	41	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NFZ0, Q7Z4Q6, Q7Z4R0, Q8N1P5, Q8N586, Q96E82, Q96K67, Q96SW7, Q9UFB2	Gene names	FBXO18, FBH1, FBX18
Domain Architecture
Description	F-box only protein 18 (EC 3.6.1.-) (F-box DNA helicase 1).

M3K13_HUMAN
θ value	2.36792 (rank : 32)	NC score	0.004890 (rank : 78)
Query Neighborhood Hits	62	Target Neighborhood Hits	911	Shared Neighborhood Hits	7
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

SPTN4_HUMAN
θ value	2.36792 (rank : 33)	NC score	0.011834 (rank : 66)
Query Neighborhood Hits	62	Target Neighborhood Hits	570	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

HUWE1_HUMAN
θ value	3.0926 (rank : 34)	NC score	0.010302 (rank : 67)
Query Neighborhood Hits	62	Target Neighborhood Hits	443	Shared Neighborhood Hits	7
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

MRCKB_MOUSE
θ value	3.0926 (rank : 35)	NC score	0.004469 (rank : 79)
Query Neighborhood Hits	62	Target Neighborhood Hits	2180	Shared Neighborhood Hits	10
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

TERA_HUMAN
θ value	3.0926 (rank : 36)	NC score	0.034422 (rank : 52)
Query Neighborhood Hits	62	Target Neighborhood Hits	76	Shared Neighborhood Hits	12
SwissProt Accessions	P55072, Q969G7	Gene names	VCP
Domain Architecture
Description	Transitional endoplasmic reticulum ATPase (TER ATPase) (15S Mg(2+)- ATPase p97 subunit) (Valosin-containing protein) (VCP).

TERA_MOUSE
θ value	3.0926 (rank : 37)	NC score	0.034429 (rank : 51)
Query Neighborhood Hits	62	Target Neighborhood Hits	76	Shared Neighborhood Hits	12
SwissProt Accessions	Q01853	Gene names	Vcp
Domain Architecture
Description	Transitional endoplasmic reticulum ATPase (TER ATPase) (15S Mg(2+)- ATPase p97 subunit) (Valosin-containing protein) (VCP).

ITPK1_MOUSE
θ value	4.03905 (rank : 38)	NC score	0.021478 (rank : 59)
Query Neighborhood Hits	62	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BYN3, Q8K0J6, Q8R0Z0	Gene names	Itpk1
Domain Architecture	No domain graphic available
Description	Inositol-tetrakisphosphate 1-kinase (EC 2.7.1.134) (Inositol- triphosphate 5/6-kinase) (EC 2.7.1.-) (Inositol 1,3,4-trisphosphate 5/6-kinase).

PAF49_MOUSE
θ value	4.03905 (rank : 39)	NC score	0.023419 (rank : 58)
Query Neighborhood Hits	62	Target Neighborhood Hits	48	Shared Neighborhood Hits	2
SwissProt Accessions	Q76KJ5, Q8K0Y9	Gene names	Cd3eap, Ase1, Paf49
Domain Architecture	No domain graphic available
Description	RNA polymerase I-associated factor PAF49 (Anti-sense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein).

RUVB1_HUMAN
θ value	4.03905 (rank : 40)	NC score	0.039434 (rank : 46)
Query Neighborhood Hits	62	Target Neighborhood Hits	78	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y265, Q9BSX9	Gene names	RUVBL1, NMP238, TIP49, TIP49A
Domain Architecture
Description	RuvB-like 1 (EC 3.6.1.-) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (TIP49a) (Pontin 52) (Nuclear matrix protein 238) (NMP 238) (54 kDa erythrocyte cytosolic protein) (ECP-54) (TIP60-associated protein 54-alpha) (TAP54-alpha).

RUVB1_MOUSE
θ value	4.03905 (rank : 41)	NC score	0.039429 (rank : 47)
Query Neighborhood Hits	62	Target Neighborhood Hits	78	Shared Neighborhood Hits	13
SwissProt Accessions	P60122, O35753	Gene names	Ruvbl1, Tip49, Tip49a
Domain Architecture
Description	RuvB-like 1 (EC 3.6.1.-) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (TIP49a) (Pontin 52) (DNA helicase p50).

DGKG_MOUSE
θ value	5.27518 (rank : 42)	NC score	0.008733 (rank : 70)
Query Neighborhood Hits	62	Target Neighborhood Hits	188	Shared Neighborhood Hits	4
SwissProt Accessions	Q91WG7	Gene names	Dgkg, Dagk3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma) (88 kDa diacylglycerol kinase).

SELPL_MOUSE
θ value	5.27518 (rank : 43)	NC score	0.029200 (rank : 55)
Query Neighborhood Hits	62	Target Neighborhood Hits	588	Shared Neighborhood Hits	7
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

SLIT2_HUMAN
θ value	5.27518 (rank : 44)	NC score	0.005450 (rank : 74)
Query Neighborhood Hits	62	Target Neighborhood Hits	708	Shared Neighborhood Hits	4
SwissProt Accessions	O94813, O95710, Q9Y5Q7	Gene names	SLIT2, SLIL3
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

SLIT2_MOUSE
θ value	5.27518 (rank : 45)	NC score	0.005442 (rank : 75)
Query Neighborhood Hits	62	Target Neighborhood Hits	684	Shared Neighborhood Hits	4
SwissProt Accessions	Q9R1B9, Q9Z166	Gene names	Slit2
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

SRRM2_MOUSE
θ value	5.27518 (rank : 46)	NC score	0.013812 (rank : 62)
Query Neighborhood Hits	62	Target Neighborhood Hits	1470	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

TRI66_HUMAN
θ value	5.27518 (rank : 47)	NC score	0.009289 (rank : 69)
Query Neighborhood Hits	62	Target Neighborhood Hits	479	Shared Neighborhood Hits	6
SwissProt Accessions	O15016, Q9BQQ4	Gene names	TRIM66, KIAA0298
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

ANC1_HUMAN
θ value	6.88961 (rank : 48)	NC score	0.012847 (rank : 64)
Query Neighborhood Hits	62	Target Neighborhood Hits	46	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H1A4, Q9BSE6, Q9H8D0	Gene names	ANAPC1, TSG24
Domain Architecture	No domain graphic available
Description	Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Protein Tsg24) (Mitotic checkpoint regulator).

CAC1H_MOUSE
θ value	6.88961 (rank : 49)	NC score	0.005295 (rank : 76)
Query Neighborhood Hits	62	Target Neighborhood Hits	230	Shared Neighborhood Hits	3
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

LRC50_HUMAN
θ value	6.88961 (rank : 50)	NC score	0.009474 (rank : 68)
Query Neighborhood Hits	62	Target Neighborhood Hits	275	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NEP3, Q69YI8, Q69YJ0, Q96LP3	Gene names	LRRC50
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 50.

PEX1_HUMAN
θ value	6.88961 (rank : 51)	NC score	0.035303 (rank : 50)
Query Neighborhood Hits	62	Target Neighborhood Hits	98	Shared Neighborhood Hits	15
SwissProt Accessions	O43933, Q96S71, Q96S72, Q96S73, Q99994	Gene names	PEX1
Domain Architecture
Description	Peroxisome biogenesis factor 1 (Peroxin-1) (Peroxisome biogenesis disorder protein 1).

ABL1_HUMAN
θ value	8.99809 (rank : 52)	NC score	-0.000202 (rank : 82)
Query Neighborhood Hits	62	Target Neighborhood Hits	1220	Shared Neighborhood Hits	9
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

CP250_MOUSE
θ value	8.99809 (rank : 53)	NC score	0.003032 (rank : 81)
Query Neighborhood Hits	62	Target Neighborhood Hits	1583	Shared Neighborhood Hits	9
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

DDX58_HUMAN
θ value	8.99809 (rank : 54)	NC score	0.035421 (rank : 49)
Query Neighborhood Hits	62	Target Neighborhood Hits	105	Shared Neighborhood Hits	7
SwissProt Accessions	O95786, Q5HYE1, Q5VYT1, Q9NT04	Gene names	DDX58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

ERCC2_MOUSE
θ value	8.99809 (rank : 55)	NC score	0.014472 (rank : 61)
Query Neighborhood Hits	62	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	O08811, Q9DC01	Gene names	Ercc2, Xpd
Domain Architecture
Description	TFIIH basal transcription factor complex helicase subunit (EC 3.6.1.-) (DNA-repair protein complementing XP-D cells) (Xeroderma pigmentosum group D-complementing protein) (CXPD) (DNA excision repair protein ERCC-2).

LONM_HUMAN
θ value	8.99809 (rank : 56)	NC score	0.032866 (rank : 54)
Query Neighborhood Hits	62	Target Neighborhood Hits	130	Shared Neighborhood Hits	14
SwissProt Accessions	P36776, P36777, Q9UQ95	Gene names	PRSS15
Domain Architecture
Description	Lon protease homolog, mitochondrial precursor (EC 3.4.21.-) (Lon protease-like protein) (LONP) (LONHs).

MDC1_MOUSE
θ value	8.99809 (rank : 57)	NC score	0.016181 (rank : 60)
Query Neighborhood Hits	62	Target Neighborhood Hits	998	Shared Neighborhood Hits	13
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

PDE4D_HUMAN
θ value	8.99809 (rank : 58)	NC score	0.003889 (rank : 80)
Query Neighborhood Hits	62	Target Neighborhood Hits	122	Shared Neighborhood Hits	3
SwissProt Accessions	Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7	Gene names	PDE4D
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).

RTN4_HUMAN
θ value	8.99809 (rank : 59)	NC score	0.013311 (rank : 63)
Query Neighborhood Hits	62	Target Neighborhood Hits	357	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NQC3, O94962, Q9BXG5, Q9H212, Q9H3I3, Q9UQ42, Q9Y293, Q9Y2Y7, Q9Y5U6	Gene names	RTN4, KIAA0886, NOGO
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) (Foocen) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5).

SIN3A_HUMAN
θ value	8.99809 (rank : 60)	NC score	0.007775 (rank : 71)
Query Neighborhood Hits	62	Target Neighborhood Hits	180	Shared Neighborhood Hits	4
SwissProt Accessions	Q96ST3, Q8N8N4, Q8NC83, Q8WV18, Q96L98, Q9UFQ1	Gene names	SIN3A
Domain Architecture
Description	Paired amphipathic helix protein Sin3a (Transcriptional corepressor Sin3a) (Histone deacetylase complex subunit Sin3a).

TAP1_MOUSE
θ value	8.99809 (rank : 61)	NC score	0.006200 (rank : 73)
Query Neighborhood Hits	62	Target Neighborhood Hits	95	Shared Neighborhood Hits	3
SwissProt Accessions	P21958	Gene names	Tap1, Abcb2, Ham-1, Ham1
Domain Architecture
Description	Antigen peptide transporter 1 (APT1) (Peptide transporter TAP1) (ATP- binding cassette sub-family B member 2) (Histocompatibility antigen modifier 1).

TDRD6_MOUSE
θ value	8.99809 (rank : 62)	NC score	0.011934 (rank : 65)
Query Neighborhood Hits	62	Target Neighborhood Hits	82	Shared Neighborhood Hits	3
SwissProt Accessions	P61407	Gene names	Tdrd6
Domain Architecture
Description	Tudor domain-containing protein 6.

CX048_HUMAN
θ value	θ > 10 (rank : 63)	NC score	0.077182 (rank : 24)
Query Neighborhood Hits	62	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WUE5, Q9NWY8	Gene names	CXorf48
Domain Architecture	No domain graphic available
Description	Protein CXorf48 (Tumor antigen BJ-HCC-20).

KRA92_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.050571 (rank : 40)
Query Neighborhood Hits	62	Target Neighborhood Hits	198	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BYQ4	Gene names	KRTAP9-2, KAP9.2, KRTAP9.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-2 (Keratin-associated protein 9.2) (Ultrahigh sulfur keratin-associated protein 9.2).

KRA98_HUMAN
θ value	θ > 10 (rank : 65)	NC score	0.057320 (rank : 34)
Query Neighborhood Hits	62	Target Neighborhood Hits	185	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BYQ0	Gene names	KRTAP9-8, KAP9.8, KRTAP9.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-8 (Keratin-associated protein 9.8) (Ultrahigh sulfur keratin-associated protein 9.8).

KRA99_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.055520 (rank : 37)
Query Neighborhood Hits	62	Target Neighborhood Hits	173	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BYP9	Gene names	KRTAP9-9, KAP9.9, KRTAP9.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-9 (Keratin-associated protein 9.9) (Ultrahigh sulfur keratin-associated protein 9.9).

LCE1D_HUMAN
θ value	θ > 10 (rank : 67)	NC score	0.055659 (rank : 36)
Query Neighborhood Hits	62	Target Neighborhood Hits	44	Shared Neighborhood Hits	2
SwissProt Accessions	Q5T752	Gene names	LCE1D, LEP4
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1D (Late envelope protein 4).

LCE2B_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.053636 (rank : 39)
Query Neighborhood Hits	62	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	O14633	Gene names	LCE2B, LEP10, SPRL1B, XP5
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2B (Late envelope protein 10) (Small proline-rich-like epidermal differentiation complex protein 1B) (Skin- specific protein Xp5).

LCE2C_HUMAN
θ value	θ > 10 (rank : 69)	NC score	0.061035 (rank : 32)
Query Neighborhood Hits	62	Target Neighborhood Hits	53	Shared Neighborhood Hits	2
SwissProt Accessions	Q5TA81	Gene names	LCE2C, LEP11
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2C (Late envelope protein 11).

LCE2D_HUMAN
θ value	θ > 10 (rank : 70)	NC score	0.068227 (rank : 28)
Query Neighborhood Hits	62	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	Q5TA82	Gene names	LCE2D, LEP12, SPRL1A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2D (Late envelope protein 12) (Small proline-rich-like epidermal differentiation complex protein 1A).

LCE5A_HUMAN
θ value	θ > 10 (rank : 71)	NC score	0.064644 (rank : 30)
Query Neighborhood Hits	62	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	Q5TCM9	Gene names	LCE5A, LEP18, SPRL5A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 5A (Late envelope protein 18) (Small proline-rich-like epidermal differentiation complex protein 5A).

NFX1_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.063412 (rank : 31)
Query Neighborhood Hits	62	Target Neighborhood Hits	405	Shared Neighborhood Hits	2
SwissProt Accessions	Q12986	Gene names	NFX1
Domain Architecture
Description	Transcriptional repressor NF-X1 (EC 6.3.2.-) (Nuclear transcription factor, X box-binding, 1).

SPR2B_HUMAN
θ value	θ > 10 (rank : 73)	NC score	0.056791 (rank : 35)
Query Neighborhood Hits	62	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	P35325, Q5T528	Gene names	SPRR2B
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2B (SPR-2B).

SPR2B_MOUSE
θ value	θ > 10 (rank : 74)	NC score	0.090773 (rank : 20)
Query Neighborhood Hits	62	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	O70554, Q7TSB2	Gene names	Sprr2b
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2B.

SPR2D_MOUSE
θ value	θ > 10 (rank : 75)	NC score	0.093120 (rank : 18)
Query Neighborhood Hits	62	Target Neighborhood Hits	61	Shared Neighborhood Hits	2
SwissProt Accessions	O70555	Gene names	Sprr2d
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2D.

SPR2E_HUMAN
θ value	θ > 10 (rank : 76)	NC score	0.084891 (rank : 22)
Query Neighborhood Hits	62	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	P22531, Q96RM2	Gene names	SPRR2E
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2E (SPR-2E) (Small proline-rich protein II) (SPR-II).

SPR2E_MOUSE
θ value	θ > 10 (rank : 77)	NC score	0.071532 (rank : 26)
Query Neighborhood Hits	62	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	O70556	Gene names	Sprr2e
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2E.

SPR2F_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.091002 (rank : 19)
Query Neighborhood Hits	62	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	Q96RM1	Gene names	SPRR2F
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2F (SPR-2F).

SPR2F_MOUSE
θ value	θ > 10 (rank : 79)	NC score	0.054912 (rank : 38)
Query Neighborhood Hits	62	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	O70557	Gene names	Sprr2f
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2F.

SPR2G_MOUSE
θ value	θ > 10 (rank : 80)	NC score	0.090314 (rank : 21)
Query Neighborhood Hits	62	Target Neighborhood Hits	53	Shared Neighborhood Hits	2
SwissProt Accessions	O70558	Gene names	Sprr2g
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2G.

SPR2H_MOUSE
θ value	θ > 10 (rank : 81)	NC score	0.080192 (rank : 23)
Query Neighborhood Hits	62	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	O70559	Gene names	Sprr2h
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2H.

SPR2I_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.074716 (rank : 25)
Query Neighborhood Hits	62	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	O70560	Gene names	Sprr2i
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2I.

Hits sorted by NC score

AQR_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	62	Target Neighborhood Hits	62	Shared Neighborhood Hits	62
SwissProt Accessions	Q8CFQ3, P97871, Q3U9N1, Q3ULE8, Q80TX8	Gene names	Aqr, Kiaa0560
Domain Architecture	No domain graphic available
Description	Intron-binding protein aquarius.

AQR_HUMAN
NC score	0.991481 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	62	Target Neighborhood Hits	88	Shared Neighborhood Hits	46
SwissProt Accessions	O60306, Q2YDX9, Q6IRU8, Q6PIC8	Gene names	AQR, KIAA0560
Domain Architecture	No domain graphic available
Description	Intron-binding protein aquarius (Intron-binding protein of 160 kDa) (IBP160).

RENT1_HUMAN
NC score	0.574432 (rank : 3)	θ value	2.97466e-19 (rank : 5)
Query Neighborhood Hits	62	Target Neighborhood Hits	51	Shared Neighborhood Hits	17
SwissProt Accessions	Q92900, O00239, O43343, Q86Z25, Q92842	Gene names	UPF1, KIAA0221, RENT1
Domain Architecture
Description	Regulator of nonsense transcripts 1 (EC 3.6.1.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up- frameshift suppressor 1 homolog) (hUpf1).

RENT1_MOUSE
NC score	0.574237 (rank : 4)	θ value	2.97466e-19 (rank : 6)
Query Neighborhood Hits	62	Target Neighborhood Hits	54	Shared Neighborhood Hits	17
SwissProt Accessions	Q9EPU0, Q99PR4	Gene names	Upf1, Rent1
Domain Architecture
Description	Regulator of nonsense transcripts 1 (EC 3.6.1.-) (ATP-dependent helicase RENT1) (Nonsense mRNA reducing factor 1) (NORF1) (Up- frameshift suppressor 1 homolog) (mUpf1).

ZNFX1_HUMAN
NC score	0.521767 (rank : 5)	θ value	2.27234e-27 (rank : 4)
Query Neighborhood Hits	62	Target Neighborhood Hits	308	Shared Neighborhood Hits	20
SwissProt Accessions	Q9P2E3, Q9BQM7, Q9BQM8, Q9H8C1, Q9H9S2, Q9NUM1, Q9NWW1	Gene names	ZNFX1, KIAA1404
Domain Architecture	No domain graphic available
Description	NFX1-type zinc finger-containing protein 1.

ZNFX1_MOUSE
NC score	0.518756 (rank : 6)	θ value	1.73987e-27 (rank : 3)
Query Neighborhood Hits	62	Target Neighborhood Hits	407	Shared Neighborhood Hits	18
SwissProt Accessions	Q8R151, Q3U016, Q3UD71, Q3UEZ0	Gene names	ZNFX1
Domain Architecture	No domain graphic available
Description	NFX1-type zinc finger-containing protein 1.

SETX_HUMAN
NC score	0.509041 (rank : 7)	θ value	9.90251e-15 (rank : 7)
Query Neighborhood Hits	62	Target Neighborhood Hits	368	Shared Neighborhood Hits	21
SwissProt Accessions	Q7Z333, O75120, Q3KQX4, Q68DW5, Q6AZD7, Q7Z3J6, Q8WX33, Q9H9D1, Q9NVP9	Gene names	SETX, ALS4, KIAA0625, SCAR1
Domain Architecture
Description	Probable helicase senataxin (EC 3.6.1.-) (SEN1 homolog).

SMBP2_MOUSE
NC score	0.486195 (rank : 8)	θ value	5.62301e-10 (rank : 8)
Query Neighborhood Hits	62	Target Neighborhood Hits	104	Shared Neighborhood Hits	17
SwissProt Accessions	P40694	Gene names	Ighmbp2, Smbp-2, Smbp2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Cardiac transcription factor 1) (CATF1).

SMBP2_HUMAN
NC score	0.481119 (rank : 9)	θ value	2.13673e-09 (rank : 9)
Query Neighborhood Hits	62	Target Neighborhood Hits	107	Shared Neighborhood Hits	17
SwissProt Accessions	P38935, Q00443, Q14177	Gene names	IGHMBP2, SMBP2, SMUBP2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Glial factor 1) (GF-1).

PR285_HUMAN
NC score	0.443960 (rank : 10)	θ value	1.06045e-08 (rank : 10)
Query Neighborhood Hits	62	Target Neighborhood Hits	63	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BYK8, Q3C2G2, Q4VXQ1, Q8TEF3, Q96ND3, Q9C094	Gene names	PRIC285, KIAA1769
Domain Architecture
Description	Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein (EC 3.6.1.-) (ATP-dependent helicase PRIC285) (PPAR-alpha- interacting complex protein 285) (PPAR-gamma DBD-interacting protein 1) (PDIP1).

M10L1_HUMAN
NC score	0.389054 (rank : 11)	θ value	2.88788e-06 (rank : 11)
Query Neighborhood Hits	62	Target Neighborhood Hits	36	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BXT6, Q5TGD5, Q8NBD4, Q9NXW3, Q9UFB3, Q9UGX9	Gene names	MOV10L1
Domain Architecture
Description	Putative helicase Mov10l1 (EC 3.6.1.-) (Moloney leukemia virus 10-like protein 1) (MOV10-like 1).

M10L1_MOUSE
NC score	0.374327 (rank : 12)	θ value	4.1701e-05 (rank : 12)
Query Neighborhood Hits	62	Target Neighborhood Hits	59	Shared Neighborhood Hits	15
SwissProt Accessions	Q99MV5, Q7TPA9, Q8C3W0, Q924C2	Gene names	Mov10l1, Champ
Domain Architecture
Description	Putative helicase Mov10l1 (EC 3.6.1.-) (Moloney leukemia virus 10-like protein 1) (MOV10-like 1) (Cardiac helicase activated by MEF2 protein) (Cardiac-specific RNA helicase).

MOV10_HUMAN
NC score	0.349095 (rank : 13)	θ value	0.00509761 (rank : 14)
Query Neighborhood Hits	62	Target Neighborhood Hits	46	Shared Neighborhood Hits	17
SwissProt Accessions	Q9HCE1, Q8TEF0, Q9BSY3, Q9BUJ9	Gene names	MOV10, KIAA1631
Domain Architecture
Description	Putative helicase MOV-10 (EC 3.6.1.-) (Moloney leukemia virus 10 protein).

MOV10_MOUSE
NC score	0.341974 (rank : 14)	θ value	0.0252991 (rank : 15)
Query Neighborhood Hits	62	Target Neighborhood Hits	39	Shared Neighborhood Hits	17
SwissProt Accessions	P23249, Q9DC64	Gene names	Mov10, Gb110
Domain Architecture
Description	Putative helicase MOV-10 (EC 3.6.1.-) (Moloney leukemia virus 10 protein).

HELZ_HUMAN
NC score	0.339732 (rank : 15)	θ value	0.00390308 (rank : 13)
Query Neighborhood Hits	62	Target Neighborhood Hits	198	Shared Neighborhood Hits	18
SwissProt Accessions	P42694	Gene names	HELZ, KIAA0054
Domain Architecture	No domain graphic available
Description	Probable helicase with zinc-finger domain (EC 3.6.1.-).

RA51D_MOUSE
NC score	0.111155 (rank : 16)	θ value	0.0563607 (rank : 16)
Query Neighborhood Hits	62	Target Neighborhood Hits	18	Shared Neighborhood Hits	4
SwissProt Accessions	O55230	Gene names	Rad51l3, R51h3, Rad51d
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD51 homolog 4 (R51H3) (RAD51-like protein 3).

RA51D_HUMAN
NC score	0.097167 (rank : 17)	θ value	0.21417 (rank : 18)
Query Neighborhood Hits	62	Target Neighborhood Hits	18	Shared Neighborhood Hits	4
SwissProt Accessions	O75771, O43537, O60355, O75196, O75847, O75848, O76073, O76085, O94908, Q9UFU5	Gene names	RAD51L3, RAD51D
Domain Architecture	No domain graphic available
Description	DNA repair protein RAD51 homolog 4 (R51H3) (RAD51-like protein 3) (TRAD).

SPR2D_MOUSE
NC score	0.093120 (rank : 18)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	62	Target Neighborhood Hits	61	Shared Neighborhood Hits	2
SwissProt Accessions	O70555	Gene names	Sprr2d
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2D.

SPR2F_HUMAN
NC score	0.091002 (rank : 19)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	62	Target Neighborhood Hits	33	Shared Neighborhood Hits	2
SwissProt Accessions	Q96RM1	Gene names	SPRR2F
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2F (SPR-2F).

SPR2B_MOUSE
NC score	0.090773 (rank : 20)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	62	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	O70554, Q7TSB2	Gene names	Sprr2b
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2B.

SPR2G_MOUSE
NC score	0.090314 (rank : 21)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	62	Target Neighborhood Hits	53	Shared Neighborhood Hits	2
SwissProt Accessions	O70558	Gene names	Sprr2g
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2G.

SPR2E_HUMAN
NC score	0.084891 (rank : 22)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	62	Target Neighborhood Hits	32	Shared Neighborhood Hits	2
SwissProt Accessions	P22531, Q96RM2	Gene names	SPRR2E
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2E (SPR-2E) (Small proline-rich protein II) (SPR-II).

SPR2H_MOUSE
NC score	0.080192 (rank : 23)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	62	Target Neighborhood Hits	82	Shared Neighborhood Hits	2
SwissProt Accessions	O70559	Gene names	Sprr2h
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2H.

CX048_HUMAN
NC score	0.077182 (rank : 24)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	62	Target Neighborhood Hits	9	Shared Neighborhood Hits	2
SwissProt Accessions	Q8WUE5, Q9NWY8	Gene names	CXorf48
Domain Architecture	No domain graphic available
Description	Protein CXorf48 (Tumor antigen BJ-HCC-20).

SPR2I_MOUSE
NC score	0.074716 (rank : 25)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	62	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	O70560	Gene names	Sprr2i
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2I.

SPR2E_MOUSE
NC score	0.071532 (rank : 26)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	62	Target Neighborhood Hits	45	Shared Neighborhood Hits	2
SwissProt Accessions	O70556	Gene names	Sprr2e
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2E.

FANCM_HUMAN
NC score	0.069223 (rank : 27)	θ value	0.365318 (rank : 19)
Query Neighborhood Hits	62	Target Neighborhood Hits	210	Shared Neighborhood Hits	8
SwissProt Accessions	Q8IYD8, Q3YFH9, Q8N9X6, Q9HCH6	Gene names	FANCM, KIAA1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog).

LCE2D_HUMAN
NC score	0.068227 (rank : 28)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	62	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	Q5TA82	Gene names	LCE2D, LEP12, SPRL1A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2D (Late envelope protein 12) (Small proline-rich-like epidermal differentiation complex protein 1A).

FANCM_MOUSE
NC score	0.067310 (rank : 29)	θ value	0.365318 (rank : 20)
Query Neighborhood Hits	62	Target Neighborhood Hits	177	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BGE5, Q69ZF5, Q8BKB7, Q8BUA8	Gene names	Fancm, Kiaa1596
Domain Architecture	No domain graphic available
Description	Fanconi anemia group M protein homolog (EC 3.6.1.-) (ATP-dependent RNA helicase FANCM) (Protein FACM).

LCE5A_HUMAN
NC score	0.064644 (rank : 30)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	62	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	Q5TCM9	Gene names	LCE5A, LEP18, SPRL5A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 5A (Late envelope protein 18) (Small proline-rich-like epidermal differentiation complex protein 5A).

NFX1_HUMAN
NC score	0.063412 (rank : 31)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	62	Target Neighborhood Hits	405	Shared Neighborhood Hits	2
SwissProt Accessions	Q12986	Gene names	NFX1
Domain Architecture
Description	Transcriptional repressor NF-X1 (EC 6.3.2.-) (Nuclear transcription factor, X box-binding, 1).

LCE2C_HUMAN
NC score	0.061035 (rank : 32)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	62	Target Neighborhood Hits	53	Shared Neighborhood Hits	2
SwissProt Accessions	Q5TA81	Gene names	LCE2C, LEP11
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2C (Late envelope protein 11).

DDX58_MOUSE
NC score	0.057684 (rank : 33)	θ value	0.163984 (rank : 17)
Query Neighborhood Hits	62	Target Neighborhood Hits	99	Shared Neighborhood Hits	7
SwissProt Accessions	Q6Q899, Q8C320, Q8C5I3, Q8C7T2	Gene names	Ddx58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

KRA98_HUMAN
NC score	0.057320 (rank : 34)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	62	Target Neighborhood Hits	185	Shared Neighborhood Hits	4
SwissProt Accessions	Q9BYQ0	Gene names	KRTAP9-8, KAP9.8, KRTAP9.8
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-8 (Keratin-associated protein 9.8) (Ultrahigh sulfur keratin-associated protein 9.8).

SPR2B_HUMAN
NC score	0.056791 (rank : 35)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	62	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	P35325, Q5T528	Gene names	SPRR2B
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2B (SPR-2B).

LCE1D_HUMAN
NC score	0.055659 (rank : 36)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	62	Target Neighborhood Hits	44	Shared Neighborhood Hits	2
SwissProt Accessions	Q5T752	Gene names	LCE1D, LEP4
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 1D (Late envelope protein 4).

KRA99_HUMAN
NC score	0.055520 (rank : 37)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	62	Target Neighborhood Hits	173	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BYP9	Gene names	KRTAP9-9, KAP9.9, KRTAP9.9
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-9 (Keratin-associated protein 9.9) (Ultrahigh sulfur keratin-associated protein 9.9).

SPR2F_MOUSE
NC score	0.054912 (rank : 38)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	62	Target Neighborhood Hits	43	Shared Neighborhood Hits	2
SwissProt Accessions	O70557	Gene names	Sprr2f
Domain Architecture	No domain graphic available
Description	Small proline-rich protein 2F.

LCE2B_HUMAN
NC score	0.053636 (rank : 39)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	62	Target Neighborhood Hits	50	Shared Neighborhood Hits	2
SwissProt Accessions	O14633	Gene names	LCE2B, LEP10, SPRL1B, XP5
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2B (Late envelope protein 10) (Small proline-rich-like epidermal differentiation complex protein 1B) (Skin- specific protein Xp5).

KRA92_HUMAN
NC score	0.050571 (rank : 40)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	62	Target Neighborhood Hits	198	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BYQ4	Gene names	KRTAP9-2, KAP9.2, KRTAP9.2
Domain Architecture	No domain graphic available
Description	Keratin-associated protein 9-2 (Keratin-associated protein 9.2) (Ultrahigh sulfur keratin-associated protein 9.2).

PEX6_MOUSE
NC score	0.046830 (rank : 41)	θ value	1.81305 (rank : 30)
Query Neighborhood Hits	62	Target Neighborhood Hits	94	Shared Neighborhood Hits	15
SwissProt Accessions	Q99LC9, Q6YNQ9	Gene names	Pex6
Domain Architecture	No domain graphic available
Description	Peroxisome assembly factor 2 (PAF-2) (Peroxisomal-type ATPase 1) (Peroxin-6) (Peroxisomal biogenesis factor 6).

PEX6_HUMAN
NC score	0.045938 (rank : 42)	θ value	1.81305 (rank : 29)
Query Neighborhood Hits	62	Target Neighborhood Hits	99	Shared Neighborhood Hits	19
SwissProt Accessions	Q13608, Q8WYQ2, Q99476	Gene names	PEX6, PXAAA1
Domain Architecture
Description	Peroxisome assembly factor 2 (PAF-2) (Peroxisomal-type ATPase 1) (Peroxin-6) (Peroxisomal biogenesis factor 6).

NVL_HUMAN
NC score	0.045391 (rank : 43)	θ value	0.62314 (rank : 21)
Query Neighborhood Hits	62	Target Neighborhood Hits	112	Shared Neighborhood Hits	14
SwissProt Accessions	O15381, Q96EM7	Gene names	NVL
Domain Architecture
Description	Nuclear valosin-containing protein-like (Nuclear VCP-like protein) (NVLp).

NVL_MOUSE
NC score	0.044950 (rank : 44)	θ value	0.62314 (rank : 22)
Query Neighborhood Hits	62	Target Neighborhood Hits	110	Shared Neighborhood Hits	12
SwissProt Accessions	Q9DBY8, Q3USC4, Q8BW27, Q8K2B5	Gene names	Nvl
Domain Architecture
Description	Nuclear valosin-containing protein-like (Nuclear VCP-like protein) (NVLp).

FBX18_HUMAN
NC score	0.044530 (rank : 45)	θ value	2.36792 (rank : 31)
Query Neighborhood Hits	62	Target Neighborhood Hits	41	Shared Neighborhood Hits	5
SwissProt Accessions	Q8NFZ0, Q7Z4Q6, Q7Z4R0, Q8N1P5, Q8N586, Q96E82, Q96K67, Q96SW7, Q9UFB2	Gene names	FBXO18, FBH1, FBX18
Domain Architecture
Description	F-box only protein 18 (EC 3.6.1.-) (F-box DNA helicase 1).

RUVB1_HUMAN
NC score	0.039434 (rank : 46)	θ value	4.03905 (rank : 40)
Query Neighborhood Hits	62	Target Neighborhood Hits	78	Shared Neighborhood Hits	13
SwissProt Accessions	Q9Y265, Q9BSX9	Gene names	RUVBL1, NMP238, TIP49, TIP49A
Domain Architecture
Description	RuvB-like 1 (EC 3.6.1.-) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (TIP49a) (Pontin 52) (Nuclear matrix protein 238) (NMP 238) (54 kDa erythrocyte cytosolic protein) (ECP-54) (TIP60-associated protein 54-alpha) (TAP54-alpha).

RUVB1_MOUSE
NC score	0.039429 (rank : 47)	θ value	4.03905 (rank : 41)
Query Neighborhood Hits	62	Target Neighborhood Hits	78	Shared Neighborhood Hits	13
SwissProt Accessions	P60122, O35753	Gene names	Ruvbl1, Tip49, Tip49a
Domain Architecture
Description	RuvB-like 1 (EC 3.6.1.-) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (TIP49a) (Pontin 52) (DNA helicase p50).

CCD27_HUMAN
NC score	0.038836 (rank : 48)	θ value	1.38821 (rank : 26)
Query Neighborhood Hits	62	Target Neighborhood Hits	594	Shared Neighborhood Hits	6
SwissProt Accessions	Q2M243, Q5TBV3, Q96M50	Gene names	CCDC27
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 27.

DDX58_HUMAN
NC score	0.035421 (rank : 49)	θ value	8.99809 (rank : 54)
Query Neighborhood Hits	62	Target Neighborhood Hits	105	Shared Neighborhood Hits	7
SwissProt Accessions	O95786, Q5HYE1, Q5VYT1, Q9NT04	Gene names	DDX58
Domain Architecture	No domain graphic available
Description	Probable ATP-dependent RNA helicase DDX58 (EC 3.6.1.-) (DEAD-box protein 58) (Retinoic acid-inducible gene 1 protein) (RIG-1) (RIG-I).

PEX1_HUMAN
NC score	0.035303 (rank : 50)	θ value	6.88961 (rank : 51)
Query Neighborhood Hits	62	Target Neighborhood Hits	98	Shared Neighborhood Hits	15
SwissProt Accessions	O43933, Q96S71, Q96S72, Q96S73, Q99994	Gene names	PEX1
Domain Architecture
Description	Peroxisome biogenesis factor 1 (Peroxin-1) (Peroxisome biogenesis disorder protein 1).

TERA_MOUSE
NC score	0.034429 (rank : 51)	θ value	3.0926 (rank : 37)
Query Neighborhood Hits	62	Target Neighborhood Hits	76	Shared Neighborhood Hits	12
SwissProt Accessions	Q01853	Gene names	Vcp
Domain Architecture
Description	Transitional endoplasmic reticulum ATPase (TER ATPase) (15S Mg(2+)- ATPase p97 subunit) (Valosin-containing protein) (VCP).

TERA_HUMAN
NC score	0.034422 (rank : 52)	θ value	3.0926 (rank : 36)
Query Neighborhood Hits	62	Target Neighborhood Hits	76	Shared Neighborhood Hits	12
SwissProt Accessions	P55072, Q969G7	Gene names	VCP
Domain Architecture
Description	Transitional endoplasmic reticulum ATPase (TER ATPase) (15S Mg(2+)- ATPase p97 subunit) (Valosin-containing protein) (VCP).

KI67_HUMAN
NC score	0.032876 (rank : 53)	θ value	0.813845 (rank : 23)
Query Neighborhood Hits	62	Target Neighborhood Hits	581	Shared Neighborhood Hits	7
SwissProt Accessions	P46013	Gene names	MKI67
Domain Architecture
Description	Antigen KI-67.

LONM_HUMAN
NC score	0.032866 (rank : 54)	θ value	8.99809 (rank : 56)
Query Neighborhood Hits	62	Target Neighborhood Hits	130	Shared Neighborhood Hits	14
SwissProt Accessions	P36776, P36777, Q9UQ95	Gene names	PRSS15
Domain Architecture
Description	Lon protease homolog, mitochondrial precursor (EC 3.4.21.-) (Lon protease-like protein) (LONP) (LONHs).

SELPL_MOUSE
NC score	0.029200 (rank : 55)	θ value	5.27518 (rank : 43)
Query Neighborhood Hits	62	Target Neighborhood Hits	588	Shared Neighborhood Hits	7
SwissProt Accessions	Q62170	Gene names	Selplg, Selp1, Selpl
Domain Architecture	No domain graphic available
Description	P-selectin glycoprotein ligand 1 precursor (PSGL-1) (Selectin P ligand).

NAL10_MOUSE
NC score	0.027885 (rank : 56)	θ value	1.38821 (rank : 27)
Query Neighborhood Hits	62	Target Neighborhood Hits	46	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CCN1	Gene names	Nalp10, Pynod
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 10.

PARP2_MOUSE
NC score	0.026820 (rank : 57)	θ value	0.813845 (rank : 24)
Query Neighborhood Hits	62	Target Neighborhood Hits	53	Shared Neighborhood Hits	2
SwissProt Accessions	O88554, Q99N29	Gene names	Parp2, Adprt2, Adprtl2, Aspartl2
Domain Architecture
Description	Poly [ADP-ribose] polymerase 2 (EC 2.4.2.30) (PARP-2) (NAD(+) ADP- ribosyltransferase 2) (Poly[ADP-ribose] synthetase 2) (pADPRT-2) (mPARP-2).

PAF49_MOUSE
NC score	0.023419 (rank : 58)	θ value	4.03905 (rank : 39)
Query Neighborhood Hits	62	Target Neighborhood Hits	48	Shared Neighborhood Hits	2
SwissProt Accessions	Q76KJ5, Q8K0Y9	Gene names	Cd3eap, Ase1, Paf49
Domain Architecture	No domain graphic available
Description	RNA polymerase I-associated factor PAF49 (Anti-sense to ERCC-1 protein) (ASE-1) (CD3-epsilon-associated protein) (CD3E-associated protein).

ITPK1_MOUSE
NC score	0.021478 (rank : 59)	θ value	4.03905 (rank : 38)
Query Neighborhood Hits	62	Target Neighborhood Hits	7	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BYN3, Q8K0J6, Q8R0Z0	Gene names	Itpk1
Domain Architecture	No domain graphic available
Description	Inositol-tetrakisphosphate 1-kinase (EC 2.7.1.134) (Inositol- triphosphate 5/6-kinase) (EC 2.7.1.-) (Inositol 1,3,4-trisphosphate 5/6-kinase).

MDC1_MOUSE
NC score	0.016181 (rank : 60)	θ value	8.99809 (rank : 57)
Query Neighborhood Hits	62	Target Neighborhood Hits	998	Shared Neighborhood Hits	13
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

ERCC2_MOUSE
NC score	0.014472 (rank : 61)	θ value	8.99809 (rank : 55)
Query Neighborhood Hits	62	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	O08811, Q9DC01	Gene names	Ercc2, Xpd
Domain Architecture
Description	TFIIH basal transcription factor complex helicase subunit (EC 3.6.1.-) (DNA-repair protein complementing XP-D cells) (Xeroderma pigmentosum group D-complementing protein) (CXPD) (DNA excision repair protein ERCC-2).

SRRM2_MOUSE
NC score	0.013812 (rank : 62)	θ value	5.27518 (rank : 46)
Query Neighborhood Hits	62	Target Neighborhood Hits	1470	Shared Neighborhood Hits	11
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

RTN4_HUMAN
NC score	0.013311 (rank : 63)	θ value	8.99809 (rank : 59)
Query Neighborhood Hits	62	Target Neighborhood Hits	357	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NQC3, O94962, Q9BXG5, Q9H212, Q9H3I3, Q9UQ42, Q9Y293, Q9Y2Y7, Q9Y5U6	Gene names	RTN4, KIAA0886, NOGO
Domain Architecture
Description	Reticulon-4 (Neurite outgrowth inhibitor) (Nogo protein) (Foocen) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5).

ANC1_HUMAN
NC score	0.012847 (rank : 64)	θ value	6.88961 (rank : 48)
Query Neighborhood Hits	62	Target Neighborhood Hits	46	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H1A4, Q9BSE6, Q9H8D0	Gene names	ANAPC1, TSG24
Domain Architecture	No domain graphic available
Description	Anaphase-promoting complex subunit 1 (APC1) (Cyclosome subunit 1) (Protein Tsg24) (Mitotic checkpoint regulator).

TDRD6_MOUSE
NC score	0.011934 (rank : 65)	θ value	8.99809 (rank : 62)
Query Neighborhood Hits	62	Target Neighborhood Hits	82	Shared Neighborhood Hits	3
SwissProt Accessions	P61407	Gene names	Tdrd6
Domain Architecture
Description	Tudor domain-containing protein 6.

SPTN4_HUMAN
NC score	0.011834 (rank : 66)	θ value	2.36792 (rank : 33)
Query Neighborhood Hits	62	Target Neighborhood Hits	570	Shared Neighborhood Hits	7
SwissProt Accessions	Q9H254, Q9H1K7, Q9H1K8, Q9H1K9, Q9H3G8, Q9HCD0	Gene names	SPTBN4, KIAA1642, SPTBN3
Domain Architecture
Description	Spectrin beta chain, brain 3 (Spectrin, non-erythroid beta chain 3) (Beta-IV spectrin).

HUWE1_HUMAN
NC score	0.010302 (rank : 67)	θ value	3.0926 (rank : 34)
Query Neighborhood Hits	62	Target Neighborhood Hits	443	Shared Neighborhood Hits	7
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

LRC50_HUMAN
NC score	0.009474 (rank : 68)	θ value	6.88961 (rank : 50)
Query Neighborhood Hits	62	Target Neighborhood Hits	275	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NEP3, Q69YI8, Q69YJ0, Q96LP3	Gene names	LRRC50
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 50.

TRI66_HUMAN
NC score	0.009289 (rank : 69)	θ value	5.27518 (rank : 47)
Query Neighborhood Hits	62	Target Neighborhood Hits	479	Shared Neighborhood Hits	6
SwissProt Accessions	O15016, Q9BQQ4	Gene names	TRIM66, KIAA0298
Domain Architecture	No domain graphic available
Description	Tripartite motif-containing protein 66.

DGKG_MOUSE
NC score	0.008733 (rank : 70)	θ value	5.27518 (rank : 42)
Query Neighborhood Hits	62	Target Neighborhood Hits	188	Shared Neighborhood Hits	4
SwissProt Accessions	Q91WG7	Gene names	Dgkg, Dagk3
Domain Architecture
Description	Diacylglycerol kinase gamma (EC 2.7.1.107) (Diglyceride kinase gamma) (DGK-gamma) (DAG kinase gamma) (88 kDa diacylglycerol kinase).

SIN3A_HUMAN
NC score	0.007775 (rank : 71)	θ value	8.99809 (rank : 60)
Query Neighborhood Hits	62	Target Neighborhood Hits	180	Shared Neighborhood Hits	4
SwissProt Accessions	Q96ST3, Q8N8N4, Q8NC83, Q8WV18, Q96L98, Q9UFQ1	Gene names	SIN3A
Domain Architecture
Description	Paired amphipathic helix protein Sin3a (Transcriptional corepressor Sin3a) (Histone deacetylase complex subunit Sin3a).

GLI2_HUMAN
NC score	0.007242 (rank : 72)	θ value	1.06291 (rank : 25)
Query Neighborhood Hits	62	Target Neighborhood Hits	971	Shared Neighborhood Hits	4
SwissProt Accessions	P10070, O60252, O60253, O60254, O60255, Q15590, Q15591	Gene names	GLI2, THP
Domain Architecture	No domain graphic available
Description	Zinc finger protein GLI2 (Tax helper protein).

TAP1_MOUSE
NC score	0.006200 (rank : 73)	θ value	8.99809 (rank : 61)
Query Neighborhood Hits	62	Target Neighborhood Hits	95	Shared Neighborhood Hits	3
SwissProt Accessions	P21958	Gene names	Tap1, Abcb2, Ham-1, Ham1
Domain Architecture
Description	Antigen peptide transporter 1 (APT1) (Peptide transporter TAP1) (ATP- binding cassette sub-family B member 2) (Histocompatibility antigen modifier 1).

SLIT2_HUMAN
NC score	0.005450 (rank : 74)	θ value	5.27518 (rank : 44)
Query Neighborhood Hits	62	Target Neighborhood Hits	708	Shared Neighborhood Hits	4
SwissProt Accessions	O94813, O95710, Q9Y5Q7	Gene names	SLIT2, SLIL3
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

SLIT2_MOUSE
NC score	0.005442 (rank : 75)	θ value	5.27518 (rank : 45)
Query Neighborhood Hits	62	Target Neighborhood Hits	684	Shared Neighborhood Hits	4
SwissProt Accessions	Q9R1B9, Q9Z166	Gene names	Slit2
Domain Architecture
Description	Slit homolog 2 protein precursor (Slit-2) [Contains: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product].

CAC1H_MOUSE
NC score	0.005295 (rank : 76)	θ value	6.88961 (rank : 49)
Query Neighborhood Hits	62	Target Neighborhood Hits	230	Shared Neighborhood Hits	3
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

MRCKB_HUMAN
NC score	0.004996 (rank : 77)	θ value	1.81305 (rank : 28)
Query Neighborhood Hits	62	Target Neighborhood Hits	2239	Shared Neighborhood Hits	12
SwissProt Accessions	Q9Y5S2, Q2L7A5, Q86TJ1, Q9ULU5	Gene names	CDC42BPB, KIAA1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

M3K13_HUMAN
NC score	0.004890 (rank : 78)	θ value	2.36792 (rank : 32)
Query Neighborhood Hits	62	Target Neighborhood Hits	911	Shared Neighborhood Hits	7
SwissProt Accessions	O43283	Gene names	MAP3K13, LZK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 13 (EC 2.7.11.25) (Mixed lineage kinase) (MLK) (Leucine zipper-bearing kinase).

MRCKB_MOUSE
NC score	0.004469 (rank : 79)	θ value	3.0926 (rank : 35)
Query Neighborhood Hits	62	Target Neighborhood Hits	2180	Shared Neighborhood Hits	10
SwissProt Accessions	Q7TT50, Q69ZR5, Q80W33	Gene names	Cdc42bpb, Kiaa1124
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (Myotonic dystrophy protein kinase-like beta) (MRCK beta) (DMPK-like beta).

PDE4D_HUMAN
NC score	0.003889 (rank : 80)	θ value	8.99809 (rank : 58)
Query Neighborhood Hits	62	Target Neighborhood Hits	122	Shared Neighborhood Hits	3
SwissProt Accessions	Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7	Gene names	PDE4D
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).

CP250_MOUSE
NC score	0.003032 (rank : 81)	θ value	8.99809 (rank : 53)
Query Neighborhood Hits	62	Target Neighborhood Hits	1583	Shared Neighborhood Hits	9
SwissProt Accessions	Q60952, Q2I8G3, Q3UTR4, Q6PFF6, Q8BLC6	Gene names	Cep250, Cep2, Inmp
Domain Architecture	No domain graphic available
Description	Centrosome-associated protein CEP250 (Centrosomal protein 2) (Centrosomal Nek2-associated protein 1) (C-Nap1) (Intranuclear matrix protein).

ABL1_HUMAN
NC score	-0.000202 (rank : 82)	θ value	8.99809 (rank : 52)
Query Neighborhood Hits	62	Target Neighborhood Hits	1220	Shared Neighborhood Hits	9
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).