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Network neighborhood for query Sequence : PRS6B_HUMAN

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PRS6B_HUMAN
SwissProt Accessions	P43686, Q96FV5, Q9UBM3, Q9UEX3	Gene names	PSMC4, TBP7
Domain Architecture
Description	26S protease regulatory subunit 6B (Proteasome 26S subunit ATPase 4) (MIP224) (MB67-interacting protein) (TAT-binding protein 7) (TBP-7).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PRS6B_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	85	Target Neighborhood Hits	85	Shared Neighborhood Hits	85
SwissProt Accessions	P43686, Q96FV5, Q9UBM3, Q9UEX3	Gene names	PSMC4, TBP7
Domain Architecture
Description	26S protease regulatory subunit 6B (Proteasome 26S subunit ATPase 4) (MIP224) (MB67-interacting protein) (TAT-binding protein 7) (TBP-7).

PRS6B_MOUSE
θ value	0 (rank : 2)	NC score	0.999590 (rank : 2)
Query Neighborhood Hits	85	Target Neighborhood Hits	89	Shared Neighborhood Hits	84
SwissProt Accessions	P54775	Gene names	Psmc4, Tbp7
Domain Architecture
Description	26S protease regulatory subunit 6B (Proteasome 26S subunit ATPase 4) (MIP224) (MB67-interacting protein) (TAT-binding protein 7) (TBP-7) (CIP21).

PRS4_HUMAN
θ value	3.0981e-109 (rank : 3)	NC score	0.991012 (rank : 3)
Query Neighborhood Hits	85	Target Neighborhood Hits	84	Shared Neighborhood Hits	57
SwissProt Accessions	P62191, P49014, Q03527, Q6IAW0, Q96AZ3	Gene names	PSMC1
Domain Architecture
Description	26S protease regulatory subunit 4 (P26s4) (Proteasome 26S subunit ATPase 1).

PRS4_MOUSE
θ value	3.0981e-109 (rank : 4)	NC score	0.991012 (rank : 4)
Query Neighborhood Hits	85	Target Neighborhood Hits	84	Shared Neighborhood Hits	57
SwissProt Accessions	P62192, P49014, Q03527, Q96AZ3	Gene names	Psmc1
Domain Architecture
Description	26S protease regulatory subunit 4 (P26s4) (Proteasome 26S subunit ATPase 1).

PRS6A_HUMAN
θ value	3.68522e-86 (rank : 5)	NC score	0.984900 (rank : 6)
Query Neighborhood Hits	85	Target Neighborhood Hits	87	Shared Neighborhood Hits	57
SwissProt Accessions	P17980, Q96HD3	Gene names	PSMC3, TBP1
Domain Architecture
Description	26S protease regulatory subunit 6A (Proteasome 26S subunit ATPase 3) (TAT-binding protein 1) (TBP-1) (Proteasome subunit P50).

PRS6A_MOUSE
θ value	3.11973e-85 (rank : 6)	NC score	0.985007 (rank : 5)
Query Neighborhood Hits	85	Target Neighborhood Hits	85	Shared Neighborhood Hits	57
SwissProt Accessions	O88685	Gene names	Psmc3, Tbp1
Domain Architecture
Description	26S protease regulatory subunit 6A (Proteasome 26S subunit ATPase 3) (TAT-binding protein 1) (TBP-1).

PRS8_HUMAN
θ value	5.50685e-82 (rank : 7)	NC score	0.983677 (rank : 9)
Query Neighborhood Hits	85	Target Neighborhood Hits	117	Shared Neighborhood Hits	57
SwissProt Accessions	P62195, O35051, O43208, P47210, P52915, P52916	Gene names	PSMC5, SUG1
Domain Architecture
Description	26S protease regulatory subunit 8 (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (p45/SUG) (Thyroid hormone receptor- interacting protein 1) (TRIP1).

PRS8_MOUSE
θ value	5.50685e-82 (rank : 8)	NC score	0.983677 (rank : 10)
Query Neighborhood Hits	85	Target Neighborhood Hits	117	Shared Neighborhood Hits	57
SwissProt Accessions	P62196, O35051, P47210, P52915, P52916, Q3UL51, Q9CWN5	Gene names	Psmc5, Sug1
Domain Architecture
Description	26S protease regulatory subunit 8 (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (p45/SUG) (mSUG1).

PRS10_HUMAN
θ value	8.79181e-80 (rank : 9)	NC score	0.984451 (rank : 7)
Query Neighborhood Hits	85	Target Neighborhood Hits	95	Shared Neighborhood Hits	61
SwissProt Accessions	P62333, P49719, Q6IBU3, Q92524	Gene names	PSMC6, SUG2
Domain Architecture
Description	26S protease regulatory subunit S10B (Proteasome subunit p42) (Proteasome 26S subunit ATPase 6).

PRS10_MOUSE
θ value	8.79181e-80 (rank : 10)	NC score	0.984451 (rank : 8)
Query Neighborhood Hits	85	Target Neighborhood Hits	95	Shared Neighborhood Hits	61
SwissProt Accessions	P62334, P49719, Q3TKK1, Q810A6, Q92524, Q9CXH9	Gene names	Psmc6, Sug2
Domain Architecture
Description	26S protease regulatory subunit S10B (Proteasome subunit p42) (Proteasome 26S subunit ATPase 6).

PRS7_HUMAN
θ value	7.45998e-71 (rank : 11)	NC score	0.982785 (rank : 11)
Query Neighborhood Hits	85	Target Neighborhood Hits	66	Shared Neighborhood Hits	57
SwissProt Accessions	P35998	Gene names	PSMC2, MSS1
Domain Architecture
Description	26S protease regulatory subunit 7 (Proteasome 26S subunit ATPase 2) (Protein MSS1).

PRS7_MOUSE
θ value	7.45998e-71 (rank : 12)	NC score	0.982774 (rank : 12)
Query Neighborhood Hits	85	Target Neighborhood Hits	67	Shared Neighborhood Hits	57
SwissProt Accessions	P46471, O08531, Q3TGX5, Q9DBA1	Gene names	Psmc2, Mss1
Domain Architecture
Description	26S protease regulatory subunit 7 (Proteasome 26S subunit ATPase 2) (Protein MSS1).

TERA_HUMAN
θ value	1.23823e-49 (rank : 13)	NC score	0.949299 (rank : 13)
Query Neighborhood Hits	85	Target Neighborhood Hits	76	Shared Neighborhood Hits	57
SwissProt Accessions	P55072, Q969G7	Gene names	VCP
Domain Architecture
Description	Transitional endoplasmic reticulum ATPase (TER ATPase) (15S Mg(2+)- ATPase p97 subunit) (Valosin-containing protein) (VCP).

TERA_MOUSE
θ value	1.61718e-49 (rank : 14)	NC score	0.949241 (rank : 14)
Query Neighborhood Hits	85	Target Neighborhood Hits	76	Shared Neighborhood Hits	57
SwissProt Accessions	Q01853	Gene names	Vcp
Domain Architecture
Description	Transitional endoplasmic reticulum ATPase (TER ATPase) (15S Mg(2+)- ATPase p97 subunit) (Valosin-containing protein) (VCP).

AFG32_MOUSE
θ value	4.40402e-47 (rank : 15)	NC score	0.939660 (rank : 19)
Query Neighborhood Hits	85	Target Neighborhood Hits	73	Shared Neighborhood Hits	57
SwissProt Accessions	Q8JZQ2	Gene names	Afg3l2
Domain Architecture	No domain graphic available
Description	AFG3-like protein 2 (EC 3.4.24.-).

AFG32_HUMAN
θ value	5.7518e-47 (rank : 16)	NC score	0.939857 (rank : 18)
Query Neighborhood Hits	85	Target Neighborhood Hits	72	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Y4W6	Gene names	AFG3L2
Domain Architecture
Description	AFG3-like protein 2 (EC 3.4.24.-) (Paraplegin-like protein).

NVL_HUMAN
θ value	9.81109e-47 (rank : 17)	NC score	0.938714 (rank : 21)
Query Neighborhood Hits	85	Target Neighborhood Hits	112	Shared Neighborhood Hits	59
SwissProt Accessions	O15381, Q96EM7	Gene names	NVL
Domain Architecture
Description	Nuclear valosin-containing protein-like (Nuclear VCP-like protein) (NVLp).

AFG31_MOUSE
θ value	2.85459e-46 (rank : 18)	NC score	0.943014 (rank : 16)
Query Neighborhood Hits	85	Target Neighborhood Hits	74	Shared Neighborhood Hits	57
SwissProt Accessions	Q920A7	Gene names	Afg3l1
Domain Architecture
Description	AFG3-like protein 1 (EC 3.4.24.-).

NVL_MOUSE
θ value	1.85029e-45 (rank : 19)	NC score	0.938853 (rank : 20)
Query Neighborhood Hits	85	Target Neighborhood Hits	110	Shared Neighborhood Hits	57
SwissProt Accessions	Q9DBY8, Q3USC4, Q8BW27, Q8K2B5	Gene names	Nvl
Domain Architecture
Description	Nuclear valosin-containing protein-like (Nuclear VCP-like protein) (NVLp).

SPG7_HUMAN
θ value	4.2656e-42 (rank : 20)	NC score	0.942729 (rank : 17)
Query Neighborhood Hits	85	Target Neighborhood Hits	71	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UQ90, O75756, Q96IB0	Gene names	SPG7, CAR, CMAR, PGN
Domain Architecture
Description	Paraplegin (EC 3.4.24.-) (Spastic paraplegia protein 7).

PEX1_HUMAN
θ value	2.19075e-38 (rank : 21)	NC score	0.943867 (rank : 15)
Query Neighborhood Hits	85	Target Neighborhood Hits	98	Shared Neighborhood Hits	57
SwissProt Accessions	O43933, Q96S71, Q96S72, Q96S73, Q99994	Gene names	PEX1
Domain Architecture
Description	Peroxisome biogenesis factor 1 (Peroxin-1) (Peroxisome biogenesis disorder protein 1).

YMEL1_MOUSE
θ value	1.20211e-36 (rank : 22)	NC score	0.929913 (rank : 24)
Query Neighborhood Hits	85	Target Neighborhood Hits	76	Shared Neighborhood Hits	55
SwissProt Accessions	O88967, Q7TNN5	Gene names	Yme1l1
Domain Architecture
Description	ATP-dependent metalloprotease YME1L1 (EC 3.4.24.-) (YME1-like protein 1) (ATP-dependent metalloprotease FtsH1).

ATAD2_MOUSE
θ value	1.12514e-34 (rank : 23)	NC score	0.888328 (rank : 40)
Query Neighborhood Hits	85	Target Neighborhood Hits	167	Shared Neighborhood Hits	57
SwissProt Accessions	Q8CDM1	Gene names	Atad2
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 2.

ATAD2_HUMAN
θ value	1.9192e-34 (rank : 24)	NC score	0.870927 (rank : 41)
Query Neighborhood Hits	85	Target Neighborhood Hits	322	Shared Neighborhood Hits	57
SwissProt Accessions	Q6PL18, Q658P2, Q68CQ0, Q6PJV6, Q8N890, Q9UHS5	Gene names	ATAD2
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 2.

KATL1_MOUSE
θ value	2.50655e-34 (rank : 25)	NC score	0.920926 (rank : 28)
Query Neighborhood Hits	85	Target Neighborhood Hits	77	Shared Neighborhood Hits	57
SwissProt Accessions	Q8K0T4	Gene names	Katnal1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A-like 1 (EC 3.6.4.3) (Katanin p60 subunit A-like 1) (p60 katanin-like 1).

KATL1_HUMAN
θ value	5.584e-34 (rank : 26)	NC score	0.920836 (rank : 29)
Query Neighborhood Hits	85	Target Neighborhood Hits	80	Shared Neighborhood Hits	57
SwissProt Accessions	Q9BW62	Gene names	KATNAL1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A-like 1 (EC 3.6.4.3) (Katanin p60 subunit A-like 1) (p60 katanin-like 1).

VPS4B_MOUSE
θ value	4.72714e-33 (rank : 27)	NC score	0.908061 (rank : 37)
Query Neighborhood Hits	85	Target Neighborhood Hits	86	Shared Neighborhood Hits	58
SwissProt Accessions	P46467, Q91W22, Q9R1C9	Gene names	Vps4b, Skd1
Domain Architecture
Description	Vacuolar protein sorting-associating protein 4B (Protein SKD1).

KTNA1_HUMAN
θ value	1.37539e-32 (rank : 28)	NC score	0.918038 (rank : 32)
Query Neighborhood Hits	85	Target Neighborhood Hits	117	Shared Neighborhood Hits	57
SwissProt Accessions	O75449, Q5TFA8, Q5TFA9, Q86VN2, Q9NU52	Gene names	KATNA1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A1 (EC 3.6.4.3) (Katanin p60 subunit A1) (p60 katanin).

VPS4B_HUMAN
θ value	1.79631e-32 (rank : 29)	NC score	0.908298 (rank : 36)
Query Neighborhood Hits	85	Target Neighborhood Hits	87	Shared Neighborhood Hits	58
SwissProt Accessions	O75351, Q9GZS7	Gene names	VPS4B, SKD1, VPS42
Domain Architecture
Description	Vacuolar protein sorting-associating protein 4B (Protein SKD1).

ATAD1_HUMAN
θ value	2.34606e-32 (rank : 30)	NC score	0.936103 (rank : 22)
Query Neighborhood Hits	85	Target Neighborhood Hits	75	Shared Neighborhood Hits	57
SwissProt Accessions	Q8NBU5, Q6P4B9, Q8N3G1, Q8WYR9, Q969Y3	Gene names	ATAD1
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 1.

ATAD1_MOUSE
θ value	2.34606e-32 (rank : 31)	NC score	0.936103 (rank : 23)
Query Neighborhood Hits	85	Target Neighborhood Hits	75	Shared Neighborhood Hits	57
SwissProt Accessions	Q9D5T0, Q3U8V2, Q9D7A4	Gene names	Atad1
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 1.

KTNA1_MOUSE
θ value	1.16434e-31 (rank : 32)	NC score	0.915946 (rank : 33)
Query Neighborhood Hits	85	Target Neighborhood Hits	123	Shared Neighborhood Hits	57
SwissProt Accessions	Q9WV86	Gene names	Katna1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A1 (EC 3.6.4.3) (Katanin p60 subunit A1) (p60 katanin) (Lipotransin).

PEX6_MOUSE
θ value	1.16434e-31 (rank : 33)	NC score	0.925036 (rank : 26)
Query Neighborhood Hits	85	Target Neighborhood Hits	94	Shared Neighborhood Hits	56
SwissProt Accessions	Q99LC9, Q6YNQ9	Gene names	Pex6
Domain Architecture	No domain graphic available
Description	Peroxisome assembly factor 2 (PAF-2) (Peroxisomal-type ATPase 1) (Peroxin-6) (Peroxisomal biogenesis factor 6).

NSF_MOUSE
θ value	4.42448e-31 (rank : 34)	NC score	0.919037 (rank : 30)
Query Neighborhood Hits	85	Target Neighborhood Hits	73	Shared Neighborhood Hits	57
SwissProt Accessions	P46460	Gene names	Nsf, Skd2
Domain Architecture
Description	Vesicle-fusing ATPase (EC 3.6.4.6) (Vesicular-fusion protein NSF) (N- ethylmaleimide sensitive fusion protein) (NEM-sensitive fusion protein) (SKD2 protein).

PEX6_HUMAN
θ value	9.8567e-31 (rank : 35)	NC score	0.925200 (rank : 25)
Query Neighborhood Hits	85	Target Neighborhood Hits	99	Shared Neighborhood Hits	58
SwissProt Accessions	Q13608, Q8WYQ2, Q99476	Gene names	PEX6, PXAAA1
Domain Architecture
Description	Peroxisome assembly factor 2 (PAF-2) (Peroxisomal-type ATPase 1) (Peroxin-6) (Peroxisomal biogenesis factor 6).

SPAST_HUMAN
θ value	1.6813e-30 (rank : 36)	NC score	0.913810 (rank : 34)
Query Neighborhood Hits	85	Target Neighborhood Hits	100	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UBP0, Q9UPR9	Gene names	SPAST, KIAA1083, SPG4
Domain Architecture
Description	Spastin.

SPAST_MOUSE
θ value	4.89182e-30 (rank : 37)	NC score	0.912149 (rank : 35)
Query Neighborhood Hits	85	Target Neighborhood Hits	138	Shared Neighborhood Hits	58
SwissProt Accessions	Q9QYY8, Q6ZPY6, Q80VE0, Q9CVK0	Gene names	Spast, Kiaa1083, Spg4
Domain Architecture	No domain graphic available
Description	Spastin.

NSF_HUMAN
θ value	8.3442e-30 (rank : 38)	NC score	0.918163 (rank : 31)
Query Neighborhood Hits	85	Target Neighborhood Hits	74	Shared Neighborhood Hits	57
SwissProt Accessions	P46459, Q9UKZ2	Gene names	NSF
Domain Architecture
Description	Vesicle-fusing ATPase (EC 3.6.4.6) (Vesicular-fusion protein NSF) (N- ethylmaleimide sensitive fusion protein) (NEM-sensitive fusion protein).

VPS4A_HUMAN
θ value	1.4233e-29 (rank : 39)	NC score	0.904539 (rank : 38)
Query Neighborhood Hits	85	Target Neighborhood Hits	95	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UN37, Q8TF07, Q9UI03, Q9Y582	Gene names	VPS4A, VPS4
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associating protein 4A (SKD2 protein) (hVPS4) (VPS4-1).

VPS4A_MOUSE
θ value	1.4233e-29 (rank : 40)	NC score	0.904517 (rank : 39)
Query Neighborhood Hits	85	Target Neighborhood Hits	94	Shared Neighborhood Hits	58
SwissProt Accessions	Q8VEJ9, Q3TXT2	Gene names	Vps4a
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associating protein 4A.

YMEL1_HUMAN
θ value	2.42779e-29 (rank : 41)	NC score	0.924669 (rank : 27)
Query Neighborhood Hits	85	Target Neighborhood Hits	73	Shared Neighborhood Hits	55
SwissProt Accessions	Q96TA2, Q9H1Q0, Q9UMR9	Gene names	YME1L1, FTSH1, YME1L
Domain Architecture
Description	ATP-dependent metalloprotease YME1L1 (EC 3.4.24.-) (YME1-like protein 1) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin- associated metalloprotease) (PAMP).

FIGN_HUMAN
θ value	1.99067e-23 (rank : 42)	NC score	0.863006 (rank : 43)
Query Neighborhood Hits	85	Target Neighborhood Hits	176	Shared Neighborhood Hits	53
SwissProt Accessions	Q5HY92, Q9H6M5, Q9NVZ9	Gene names	FIGN
Domain Architecture	No domain graphic available
Description	Fidgetin.

FIGN_MOUSE
θ value	3.39556e-23 (rank : 43)	NC score	0.868300 (rank : 42)
Query Neighborhood Hits	85	Target Neighborhood Hits	165	Shared Neighborhood Hits	53
SwissProt Accessions	Q9ERZ6, Q3TPB0, Q3UP57, Q6PCM0	Gene names	Fign
Domain Architecture	No domain graphic available
Description	Fidgetin.

ATAD3_MOUSE
θ value	1.06045e-08 (rank : 44)	NC score	0.614427 (rank : 50)
Query Neighborhood Hits	85	Target Neighborhood Hits	326	Shared Neighborhood Hits	61
SwissProt Accessions	Q925I1, Q3UE74, Q69ZM7, Q8C6C6	Gene names	Atad3, Atad3a, Kiaa1273
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3 (AAA-ATPase TOB3).

BCS1_HUMAN
θ value	1.80886e-08 (rank : 45)	NC score	0.705653 (rank : 45)
Query Neighborhood Hits	85	Target Neighborhood Hits	61	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y276, Q7Z2V7	Gene names	BCS1L, BCS1
Domain Architecture
Description	Mitochondrial chaperone BCS1 (BCS1-like protein) (H-BCS1).

BCS1_MOUSE
θ value	3.08544e-08 (rank : 46)	NC score	0.697096 (rank : 47)
Query Neighborhood Hits	85	Target Neighborhood Hits	64	Shared Neighborhood Hits	50
SwissProt Accessions	Q9CZP5	Gene names	Bcs1l
Domain Architecture
Description	Mitochondrial chaperone BCS1 (BCS1-like protein).

TRP13_MOUSE
θ value	5.26297e-08 (rank : 47)	NC score	0.709416 (rank : 44)
Query Neighborhood Hits	85	Target Neighborhood Hits	81	Shared Neighborhood Hits	52
SwissProt Accessions	Q3UA06, Q3UQG6, Q9CWW8	Gene names	Trip13
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 13 (Thyroid hormone receptor interactor 13) (Trip-13).

TRP13_HUMAN
θ value	1.17247e-07 (rank : 48)	NC score	0.705368 (rank : 46)
Query Neighborhood Hits	85	Target Neighborhood Hits	81	Shared Neighborhood Hits	52
SwissProt Accessions	Q15645, O15324	Gene names	TRIP13
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 13 (Thyroid hormone receptor interactor 13) (Trip-13) (Human papillomavirus type 16 E1 protein- binding protein) (HPV16 E1 protein-binding protein) (16E1-BP).

ATD3A_HUMAN
θ value	1.99992e-07 (rank : 49)	NC score	0.631246 (rank : 48)
Query Neighborhood Hits	85	Target Neighborhood Hits	248	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NVI7, Q8N275, Q96A50	Gene names	ATAD3A
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3A.

ATD3B_HUMAN
θ value	3.41135e-07 (rank : 50)	NC score	0.620991 (rank : 49)
Query Neighborhood Hits	85	Target Neighborhood Hits	340	Shared Neighborhood Hits	60
SwissProt Accessions	Q5T9A4, Q6ZRB5, Q9BUK4, Q9ULE7	Gene names	ATAD3B, KIAA1273
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3B.

WRIP1_MOUSE
θ value	0.00175202 (rank : 51)	NC score	0.268067 (rank : 56)
Query Neighborhood Hits	85	Target Neighborhood Hits	93	Shared Neighborhood Hits	46
SwissProt Accessions	Q91XU0, Q3TCT7, Q6PDF0, Q8BUW5, Q8BWP6, Q8BY55, Q921W3, Q9EQL3	Gene names	Wrnip1, Whip
Domain Architecture	No domain graphic available
Description	ATPase WRNIP1 (Werner helicase-interacting protein 1).

LONM_HUMAN
θ value	0.00509761 (rank : 52)	NC score	0.440910 (rank : 51)
Query Neighborhood Hits	85	Target Neighborhood Hits	130	Shared Neighborhood Hits	56
SwissProt Accessions	P36776, P36777, Q9UQ95	Gene names	PRSS15
Domain Architecture
Description	Lon protease homolog, mitochondrial precursor (EC 3.4.21.-) (Lon protease-like protein) (LONP) (LONHs).

WRIP1_HUMAN
θ value	0.00869519 (rank : 53)	NC score	0.263845 (rank : 57)
Query Neighborhood Hits	85	Target Neighborhood Hits	100	Shared Neighborhood Hits	47
SwissProt Accessions	Q96S55, Q53EP6, Q59ET8, Q5W0E2, Q5W0E4, Q8WV26, Q9H681, Q9NRJ6	Gene names	WRNIP1, WHIP
Domain Architecture	No domain graphic available
Description	ATPase WRNIP1 (Werner helicase-interacting protein 1).

RUVB1_HUMAN
θ value	0.125558 (rank : 54)	NC score	0.309341 (rank : 54)
Query Neighborhood Hits	85	Target Neighborhood Hits	78	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y265, Q9BSX9	Gene names	RUVBL1, NMP238, TIP49, TIP49A
Domain Architecture
Description	RuvB-like 1 (EC 3.6.1.-) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (TIP49a) (Pontin 52) (Nuclear matrix protein 238) (NMP 238) (54 kDa erythrocyte cytosolic protein) (ECP-54) (TIP60-associated protein 54-alpha) (TAP54-alpha).

RUVB1_MOUSE
θ value	0.125558 (rank : 55)	NC score	0.309302 (rank : 55)
Query Neighborhood Hits	85	Target Neighborhood Hits	78	Shared Neighborhood Hits	51
SwissProt Accessions	P60122, O35753	Gene names	Ruvbl1, Tip49, Tip49a
Domain Architecture
Description	RuvB-like 1 (EC 3.6.1.-) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (TIP49a) (Pontin 52) (DNA helicase p50).

SYCP1_MOUSE
θ value	0.125558 (rank : 56)	NC score	0.011095 (rank : 79)
Query Neighborhood Hits	85	Target Neighborhood Hits	1456	Shared Neighborhood Hits	18
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

CCD41_MOUSE
θ value	0.163984 (rank : 57)	NC score	0.008848 (rank : 80)
Query Neighborhood Hits	85	Target Neighborhood Hits	1399	Shared Neighborhood Hits	21
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

STAT2_MOUSE
θ value	0.163984 (rank : 58)	NC score	0.011097 (rank : 78)
Query Neighborhood Hits	85	Target Neighborhood Hits	175	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WVL2, Q64188, Q64189, Q64250	Gene names	Stat2
Domain Architecture
Description	Signal transducer and activator of transcription 2.

CLPX_HUMAN
θ value	0.21417 (rank : 59)	NC score	0.421666 (rank : 52)
Query Neighborhood Hits	85	Target Neighborhood Hits	72	Shared Neighborhood Hits	52
SwissProt Accessions	O76031, Q9H4D9	Gene names	CLPX
Domain Architecture
Description	ATP-dependent Clp protease ATP-binding subunit ClpX-like, mitochondrial precursor.

CLPX_MOUSE
θ value	0.21417 (rank : 60)	NC score	0.419682 (rank : 53)
Query Neighborhood Hits	85	Target Neighborhood Hits	73	Shared Neighborhood Hits	52
SwissProt Accessions	Q9JHS4, Q9WVD1	Gene names	Clpx
Domain Architecture
Description	ATP-dependent Clp protease ATP-binding subunit ClpX-like, mitochondrial precursor.

LSD1_HUMAN
θ value	0.21417 (rank : 61)	NC score	0.029262 (rank : 71)
Query Neighborhood Hits	85	Target Neighborhood Hits	455	Shared Neighborhood Hits	11
SwissProt Accessions	O60341, Q5TH94, Q5TH95, Q86VT7, Q8IXK4, Q8NDP6, Q8TAZ3, Q96AW4	Gene names	AOF2, KIAA0601, LSD1
Domain Architecture	No domain graphic available
Description	Lysine-specific histone demethylase 1 (EC 1.-.-.-) (Flavin-containing amine oxidase domain-containing protein 2) (BRAF35-HDAC complex protein BHC110).

LSD1_MOUSE
θ value	0.21417 (rank : 62)	NC score	0.032522 (rank : 70)
Query Neighborhood Hits	85	Target Neighborhood Hits	224	Shared Neighborhood Hits	11
SwissProt Accessions	Q6ZQ88, Q6PB53, Q8VEA1	Gene names	Aof2, Kiaa0601, Lsd1
Domain Architecture	No domain graphic available
Description	Lysine-specific histone demethylase 1 (EC 1.-.-.-) (Flavin-containing amine oxidase domain-containing protein 2) (BRAF35-HDAC complex protein BHC110).

CLPB_HUMAN
θ value	0.47712 (rank : 63)	NC score	0.025465 (rank : 72)
Query Neighborhood Hits	85	Target Neighborhood Hits	265	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H078, Q8ND11, Q9H8Y0	Gene names	CLPB, SKD3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

SYNE1_HUMAN
θ value	0.47712 (rank : 64)	NC score	0.007780 (rank : 83)
Query Neighborhood Hits	85	Target Neighborhood Hits	1484	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

CLPB_MOUSE
θ value	0.62314 (rank : 65)	NC score	0.020356 (rank : 74)
Query Neighborhood Hits	85	Target Neighborhood Hits	289	Shared Neighborhood Hits	6
SwissProt Accessions	Q60649	Gene names	Clpb, Skd3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

CFLAR_MOUSE
θ value	1.06291 (rank : 66)	NC score	0.022001 (rank : 73)
Query Neighborhood Hits	85	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	O35732, O35707, O35733	Gene names	Cflar, Cash
Domain Architecture
Description	CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].

HSF2_HUMAN
θ value	2.36792 (rank : 67)	NC score	0.017647 (rank : 75)
Query Neighborhood Hits	85	Target Neighborhood Hits	149	Shared Neighborhood Hits	7
SwissProt Accessions	Q03933, Q9H445	Gene names	HSF2, HSTF2
Domain Architecture
Description	Heat shock factor protein 2 (HSF 2) (Heat shock transcription factor 2) (HSTF 2).

HSF2_MOUSE
θ value	2.36792 (rank : 68)	NC score	0.017578 (rank : 76)
Query Neighborhood Hits	85	Target Neighborhood Hits	153	Shared Neighborhood Hits	7
SwissProt Accessions	P38533, Q64157, Q8VEJ0, Q9Z2L8	Gene names	Hsf2
Domain Architecture
Description	Heat shock factor protein 2 (HSF 2) (Heat shock transcription factor 2) (HSTF 2).

NIN_MOUSE
θ value	3.0926 (rank : 69)	NC score	0.006617 (rank : 87)
Query Neighborhood Hits	85	Target Neighborhood Hits	1376	Shared Neighborhood Hits	21
SwissProt Accessions	Q61043, Q6ZPM7	Gene names	Nin, Kiaa1565
Domain Architecture	No domain graphic available
Description	Ninein.

RIPK1_HUMAN
θ value	3.0926 (rank : 70)	NC score	-0.003940 (rank : 97)
Query Neighborhood Hits	85	Target Neighborhood Hits	891	Shared Neighborhood Hits	6
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).

CASP_HUMAN
θ value	4.03905 (rank : 71)	NC score	0.007210 (rank : 84)
Query Neighborhood Hits	85	Target Neighborhood Hits	1131	Shared Neighborhood Hits	22
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CUTL1_HUMAN
θ value	4.03905 (rank : 72)	NC score	0.005834 (rank : 89)
Query Neighborhood Hits	85	Target Neighborhood Hits	1574	Shared Neighborhood Hits	24
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

NIN_HUMAN
θ value	5.27518 (rank : 73)	NC score	0.005745 (rank : 90)
Query Neighborhood Hits	85	Target Neighborhood Hits	1416	Shared Neighborhood Hits	23
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

PK2L2_HUMAN
θ value	5.27518 (rank : 74)	NC score	0.006356 (rank : 88)
Query Neighborhood Hits	85	Target Neighborhood Hits	90	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

U334_MOUSE
θ value	5.27518 (rank : 75)	NC score	0.015935 (rank : 77)
Query Neighborhood Hits	85	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CQA9	Gene names
Domain Architecture	No domain graphic available
Description	Probable UPF0334 kinase-like protein C1orf57 homolog.

ROCK1_HUMAN
θ value	6.88961 (rank : 76)	NC score	-0.003399 (rank : 95)
Query Neighborhood Hits	85	Target Neighborhood Hits	2000	Shared Neighborhood Hits	22
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

ROCK1_MOUSE
θ value	6.88961 (rank : 77)	NC score	-0.003407 (rank : 96)
Query Neighborhood Hits	85	Target Neighborhood Hits	2126	Shared Neighborhood Hits	24
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

TACC2_HUMAN
θ value	6.88961 (rank : 78)	NC score	0.008788 (rank : 81)
Query Neighborhood Hits	85	Target Neighborhood Hits	856	Shared Neighborhood Hits	18
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

TACC2_MOUSE
θ value	6.88961 (rank : 79)	NC score	0.008580 (rank : 82)
Query Neighborhood Hits	85	Target Neighborhood Hits	774	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

ULK3_MOUSE
θ value	6.88961 (rank : 80)	NC score	0.002127 (rank : 92)
Query Neighborhood Hits	85	Target Neighborhood Hits	872	Shared Neighborhood Hits	10
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

KIF5C_HUMAN
θ value	8.99809 (rank : 81)	NC score	0.001324 (rank : 93)
Query Neighborhood Hits	85	Target Neighborhood Hits	974	Shared Neighborhood Hits	18
SwissProt Accessions	O60282, O95079	Gene names	KIF5C, KIAA0531, NKHC2
Domain Architecture	No domain graphic available
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

KIF5C_MOUSE
θ value	8.99809 (rank : 82)	NC score	0.000993 (rank : 94)
Query Neighborhood Hits	85	Target Neighborhood Hits	1040	Shared Neighborhood Hits	16
SwissProt Accessions	P28738, Q9Z2F8	Gene names	Kif5c, Nkhc2
Domain Architecture
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

TACC1_MOUSE
θ value	8.99809 (rank : 83)	NC score	0.005274 (rank : 91)
Query Neighborhood Hits	85	Target Neighborhood Hits	667	Shared Neighborhood Hits	16
SwissProt Accessions	Q6Y685, Q6Y686	Gene names	Tacc1
Domain Architecture	No domain graphic available
Description	Transforming acidic coiled-coil-containing protein 1.

VPP1_HUMAN
θ value	8.99809 (rank : 84)	NC score	0.007016 (rank : 85)
Query Neighborhood Hits	85	Target Neighborhood Hits	28	Shared Neighborhood Hits	5
SwissProt Accessions	Q93050, Q8N5G7, Q9NSX0	Gene names	ATP6V0A1, ATP6N1, VPP1
Domain Architecture
Description	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1 (V- ATPase 116 kDa isoform a1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar proton pump subunit 1) (Vacuolar adenosine triphosphatase subunit Ac116).

VPP1_MOUSE
θ value	8.99809 (rank : 85)	NC score	0.006843 (rank : 86)
Query Neighborhood Hits	85	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z1G4, Q9JHJ4, Q9JL13, Q9JL14	Gene names	Atp6v0a1, Atp6n1
Domain Architecture
Description	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1 (V- ATPase 116 kDa isoform a1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar proton pump subunit 1) (Vacuolar adenosine triphosphatase subunit Ac116).

KAD6_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.090267 (rank : 65)
Query Neighborhood Hits	85	Target Neighborhood Hits	46	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y3D8	Gene names	AK6
Domain Architecture
Description	Adenylate kinase isoenzyme 6 (EC 2.7.4.3) (ATP-AMP transphosphorylase 6).

KAD6_MOUSE
θ value	θ > 10 (rank : 87)	NC score	0.069535 (rank : 67)
Query Neighborhood Hits	85	Target Neighborhood Hits	34	Shared Neighborhood Hits	18
SwissProt Accessions	Q8VCP8	Gene names	Ak6
Domain Architecture	No domain graphic available
Description	Adenylate kinase isoenzyme 6 (EC 2.7.4.3) (ATP-AMP transphosphorylase 6).

RFC1_HUMAN
θ value	θ > 10 (rank : 88)	NC score	0.092651 (rank : 63)
Query Neighborhood Hits	85	Target Neighborhood Hits	352	Shared Neighborhood Hits	37
SwissProt Accessions	P35251, Q5XKF5, Q6PKU0, Q86V41, Q86V46	Gene names	RFC1, RFC140
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (DNA-binding protein PO-GA).

RFC1_MOUSE
θ value	θ > 10 (rank : 89)	NC score	0.106348 (rank : 60)
Query Neighborhood Hits	85	Target Neighborhood Hits	290	Shared Neighborhood Hits	42
SwissProt Accessions	P35601	Gene names	Rfc1, Ibf-1, Recc1
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (A1-P145) (Differentiation- specific element-binding protein) (ISRE-binding protein).

RFC4_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.092199 (rank : 64)
Query Neighborhood Hits	85	Target Neighborhood Hits	64	Shared Neighborhood Hits	34
SwissProt Accessions	P35249, Q6FHX7	Gene names	RFC4
Domain Architecture
Description	Replication factor C subunit 4 (Replication factor C 37 kDa subunit) (RF-C 37 kDa subunit) (RFC37) (Activator 1 37 kDa subunit) (A1 37 kDa subunit).

RFC4_MOUSE
θ value	θ > 10 (rank : 91)	NC score	0.081594 (rank : 66)
Query Neighborhood Hits	85	Target Neighborhood Hits	65	Shared Neighborhood Hits	34
SwissProt Accessions	Q99J62	Gene names	Rfc4
Domain Architecture	No domain graphic available
Description	Replication factor C subunit 4.

RFC5_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.064522 (rank : 69)
Query Neighborhood Hits	85	Target Neighborhood Hits	60	Shared Neighborhood Hits	26
SwissProt Accessions	P40937	Gene names	RFC5
Domain Architecture
Description	Replication factor C subunit 5 (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36) (Activator 1 36 kDa subunit) (A1 36 kDa subunit).

RFC5_MOUSE
θ value	θ > 10 (rank : 93)	NC score	0.065303 (rank : 68)
Query Neighborhood Hits	85	Target Neighborhood Hits	58	Shared Neighborhood Hits	28
SwissProt Accessions	Q9D0F6	Gene names	Rfc5
Domain Architecture
Description	Replication factor C subunit 5 (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36) (Activator 1 36 kDa subunit) (A1 36 kDa subunit).

RUVB2_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.112541 (rank : 58)
Query Neighborhood Hits	85	Target Neighborhood Hits	43	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y230, Q6PK27, Q9Y361	Gene names	RUVBL2, TIP48, TIP49B
Domain Architecture
Description	RuvB-like 2 (EC 3.6.1.-) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (TIP49b) (Repressing pontin 52) (Reptin 52) (51 kDa erythrocyte cytosolic protein) (ECP-51) (TIP60-associated protein 54-beta) (TAP54-beta).

RUVB2_MOUSE
θ value	θ > 10 (rank : 95)	NC score	0.110014 (rank : 59)
Query Neighborhood Hits	85	Target Neighborhood Hits	42	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WTM5	Gene names	Ruvbl2
Domain Architecture
Description	RuvB-like 2 (EC 3.6.1.-) (p47 protein).

THNSL_HUMAN
θ value	θ > 10 (rank : 96)	NC score	0.095378 (rank : 62)
Query Neighborhood Hits	85	Target Neighborhood Hits	47	Shared Neighborhood Hits	31
SwissProt Accessions	Q8IYQ7, Q5VV21	Gene names	THNSL1
Domain Architecture	No domain graphic available
Description	Threonine synthase-like 1.

THNSL_MOUSE
θ value	θ > 10 (rank : 97)	NC score	0.098340 (rank : 61)
Query Neighborhood Hits	85	Target Neighborhood Hits	47	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BH55	Gene names	Thnsl1
Domain Architecture	No domain graphic available
Description	Threonine synthase-like 1.

Hits sorted by NC score

PRS6B_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	85	Target Neighborhood Hits	85	Shared Neighborhood Hits	85
SwissProt Accessions	P43686, Q96FV5, Q9UBM3, Q9UEX3	Gene names	PSMC4, TBP7
Domain Architecture
Description	26S protease regulatory subunit 6B (Proteasome 26S subunit ATPase 4) (MIP224) (MB67-interacting protein) (TAT-binding protein 7) (TBP-7).

PRS6B_MOUSE
NC score	0.999590 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	85	Target Neighborhood Hits	89	Shared Neighborhood Hits	84
SwissProt Accessions	P54775	Gene names	Psmc4, Tbp7
Domain Architecture
Description	26S protease regulatory subunit 6B (Proteasome 26S subunit ATPase 4) (MIP224) (MB67-interacting protein) (TAT-binding protein 7) (TBP-7) (CIP21).

PRS4_HUMAN
NC score	0.991012 (rank : 3)	θ value	3.0981e-109 (rank : 3)
Query Neighborhood Hits	85	Target Neighborhood Hits	84	Shared Neighborhood Hits	57
SwissProt Accessions	P62191, P49014, Q03527, Q6IAW0, Q96AZ3	Gene names	PSMC1
Domain Architecture
Description	26S protease regulatory subunit 4 (P26s4) (Proteasome 26S subunit ATPase 1).

PRS4_MOUSE
NC score	0.991012 (rank : 4)	θ value	3.0981e-109 (rank : 4)
Query Neighborhood Hits	85	Target Neighborhood Hits	84	Shared Neighborhood Hits	57
SwissProt Accessions	P62192, P49014, Q03527, Q96AZ3	Gene names	Psmc1
Domain Architecture
Description	26S protease regulatory subunit 4 (P26s4) (Proteasome 26S subunit ATPase 1).

PRS6A_MOUSE
NC score	0.985007 (rank : 5)	θ value	3.11973e-85 (rank : 6)
Query Neighborhood Hits	85	Target Neighborhood Hits	85	Shared Neighborhood Hits	57
SwissProt Accessions	O88685	Gene names	Psmc3, Tbp1
Domain Architecture
Description	26S protease regulatory subunit 6A (Proteasome 26S subunit ATPase 3) (TAT-binding protein 1) (TBP-1).

PRS6A_HUMAN
NC score	0.984900 (rank : 6)	θ value	3.68522e-86 (rank : 5)
Query Neighborhood Hits	85	Target Neighborhood Hits	87	Shared Neighborhood Hits	57
SwissProt Accessions	P17980, Q96HD3	Gene names	PSMC3, TBP1
Domain Architecture
Description	26S protease regulatory subunit 6A (Proteasome 26S subunit ATPase 3) (TAT-binding protein 1) (TBP-1) (Proteasome subunit P50).

PRS10_HUMAN
NC score	0.984451 (rank : 7)	θ value	8.79181e-80 (rank : 9)
Query Neighborhood Hits	85	Target Neighborhood Hits	95	Shared Neighborhood Hits	61
SwissProt Accessions	P62333, P49719, Q6IBU3, Q92524	Gene names	PSMC6, SUG2
Domain Architecture
Description	26S protease regulatory subunit S10B (Proteasome subunit p42) (Proteasome 26S subunit ATPase 6).

PRS10_MOUSE
NC score	0.984451 (rank : 8)	θ value	8.79181e-80 (rank : 10)
Query Neighborhood Hits	85	Target Neighborhood Hits	95	Shared Neighborhood Hits	61
SwissProt Accessions	P62334, P49719, Q3TKK1, Q810A6, Q92524, Q9CXH9	Gene names	Psmc6, Sug2
Domain Architecture
Description	26S protease regulatory subunit S10B (Proteasome subunit p42) (Proteasome 26S subunit ATPase 6).

PRS8_HUMAN
NC score	0.983677 (rank : 9)	θ value	5.50685e-82 (rank : 7)
Query Neighborhood Hits	85	Target Neighborhood Hits	117	Shared Neighborhood Hits	57
SwissProt Accessions	P62195, O35051, O43208, P47210, P52915, P52916	Gene names	PSMC5, SUG1
Domain Architecture
Description	26S protease regulatory subunit 8 (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (p45/SUG) (Thyroid hormone receptor- interacting protein 1) (TRIP1).

PRS8_MOUSE
NC score	0.983677 (rank : 10)	θ value	5.50685e-82 (rank : 8)
Query Neighborhood Hits	85	Target Neighborhood Hits	117	Shared Neighborhood Hits	57
SwissProt Accessions	P62196, O35051, P47210, P52915, P52916, Q3UL51, Q9CWN5	Gene names	Psmc5, Sug1
Domain Architecture
Description	26S protease regulatory subunit 8 (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (p45/SUG) (mSUG1).

PRS7_HUMAN
NC score	0.982785 (rank : 11)	θ value	7.45998e-71 (rank : 11)
Query Neighborhood Hits	85	Target Neighborhood Hits	66	Shared Neighborhood Hits	57
SwissProt Accessions	P35998	Gene names	PSMC2, MSS1
Domain Architecture
Description	26S protease regulatory subunit 7 (Proteasome 26S subunit ATPase 2) (Protein MSS1).

PRS7_MOUSE
NC score	0.982774 (rank : 12)	θ value	7.45998e-71 (rank : 12)
Query Neighborhood Hits	85	Target Neighborhood Hits	67	Shared Neighborhood Hits	57
SwissProt Accessions	P46471, O08531, Q3TGX5, Q9DBA1	Gene names	Psmc2, Mss1
Domain Architecture
Description	26S protease regulatory subunit 7 (Proteasome 26S subunit ATPase 2) (Protein MSS1).

TERA_HUMAN
NC score	0.949299 (rank : 13)	θ value	1.23823e-49 (rank : 13)
Query Neighborhood Hits	85	Target Neighborhood Hits	76	Shared Neighborhood Hits	57
SwissProt Accessions	P55072, Q969G7	Gene names	VCP
Domain Architecture
Description	Transitional endoplasmic reticulum ATPase (TER ATPase) (15S Mg(2+)- ATPase p97 subunit) (Valosin-containing protein) (VCP).

TERA_MOUSE
NC score	0.949241 (rank : 14)	θ value	1.61718e-49 (rank : 14)
Query Neighborhood Hits	85	Target Neighborhood Hits	76	Shared Neighborhood Hits	57
SwissProt Accessions	Q01853	Gene names	Vcp
Domain Architecture
Description	Transitional endoplasmic reticulum ATPase (TER ATPase) (15S Mg(2+)- ATPase p97 subunit) (Valosin-containing protein) (VCP).

PEX1_HUMAN
NC score	0.943867 (rank : 15)	θ value	2.19075e-38 (rank : 21)
Query Neighborhood Hits	85	Target Neighborhood Hits	98	Shared Neighborhood Hits	57
SwissProt Accessions	O43933, Q96S71, Q96S72, Q96S73, Q99994	Gene names	PEX1
Domain Architecture
Description	Peroxisome biogenesis factor 1 (Peroxin-1) (Peroxisome biogenesis disorder protein 1).

AFG31_MOUSE
NC score	0.943014 (rank : 16)	θ value	2.85459e-46 (rank : 18)
Query Neighborhood Hits	85	Target Neighborhood Hits	74	Shared Neighborhood Hits	57
SwissProt Accessions	Q920A7	Gene names	Afg3l1
Domain Architecture
Description	AFG3-like protein 1 (EC 3.4.24.-).

SPG7_HUMAN
NC score	0.942729 (rank : 17)	θ value	4.2656e-42 (rank : 20)
Query Neighborhood Hits	85	Target Neighborhood Hits	71	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UQ90, O75756, Q96IB0	Gene names	SPG7, CAR, CMAR, PGN
Domain Architecture
Description	Paraplegin (EC 3.4.24.-) (Spastic paraplegia protein 7).

AFG32_HUMAN
NC score	0.939857 (rank : 18)	θ value	5.7518e-47 (rank : 16)
Query Neighborhood Hits	85	Target Neighborhood Hits	72	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Y4W6	Gene names	AFG3L2
Domain Architecture
Description	AFG3-like protein 2 (EC 3.4.24.-) (Paraplegin-like protein).

AFG32_MOUSE
NC score	0.939660 (rank : 19)	θ value	4.40402e-47 (rank : 15)
Query Neighborhood Hits	85	Target Neighborhood Hits	73	Shared Neighborhood Hits	57
SwissProt Accessions	Q8JZQ2	Gene names	Afg3l2
Domain Architecture	No domain graphic available
Description	AFG3-like protein 2 (EC 3.4.24.-).

NVL_MOUSE
NC score	0.938853 (rank : 20)	θ value	1.85029e-45 (rank : 19)
Query Neighborhood Hits	85	Target Neighborhood Hits	110	Shared Neighborhood Hits	57
SwissProt Accessions	Q9DBY8, Q3USC4, Q8BW27, Q8K2B5	Gene names	Nvl
Domain Architecture
Description	Nuclear valosin-containing protein-like (Nuclear VCP-like protein) (NVLp).

NVL_HUMAN
NC score	0.938714 (rank : 21)	θ value	9.81109e-47 (rank : 17)
Query Neighborhood Hits	85	Target Neighborhood Hits	112	Shared Neighborhood Hits	59
SwissProt Accessions	O15381, Q96EM7	Gene names	NVL
Domain Architecture
Description	Nuclear valosin-containing protein-like (Nuclear VCP-like protein) (NVLp).

ATAD1_HUMAN
NC score	0.936103 (rank : 22)	θ value	2.34606e-32 (rank : 30)
Query Neighborhood Hits	85	Target Neighborhood Hits	75	Shared Neighborhood Hits	57
SwissProt Accessions	Q8NBU5, Q6P4B9, Q8N3G1, Q8WYR9, Q969Y3	Gene names	ATAD1
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 1.

ATAD1_MOUSE
NC score	0.936103 (rank : 23)	θ value	2.34606e-32 (rank : 31)
Query Neighborhood Hits	85	Target Neighborhood Hits	75	Shared Neighborhood Hits	57
SwissProt Accessions	Q9D5T0, Q3U8V2, Q9D7A4	Gene names	Atad1
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 1.

YMEL1_MOUSE
NC score	0.929913 (rank : 24)	θ value	1.20211e-36 (rank : 22)
Query Neighborhood Hits	85	Target Neighborhood Hits	76	Shared Neighborhood Hits	55
SwissProt Accessions	O88967, Q7TNN5	Gene names	Yme1l1
Domain Architecture
Description	ATP-dependent metalloprotease YME1L1 (EC 3.4.24.-) (YME1-like protein 1) (ATP-dependent metalloprotease FtsH1).

PEX6_HUMAN
NC score	0.925200 (rank : 25)	θ value	9.8567e-31 (rank : 35)
Query Neighborhood Hits	85	Target Neighborhood Hits	99	Shared Neighborhood Hits	58
SwissProt Accessions	Q13608, Q8WYQ2, Q99476	Gene names	PEX6, PXAAA1
Domain Architecture
Description	Peroxisome assembly factor 2 (PAF-2) (Peroxisomal-type ATPase 1) (Peroxin-6) (Peroxisomal biogenesis factor 6).

PEX6_MOUSE
NC score	0.925036 (rank : 26)	θ value	1.16434e-31 (rank : 33)
Query Neighborhood Hits	85	Target Neighborhood Hits	94	Shared Neighborhood Hits	56
SwissProt Accessions	Q99LC9, Q6YNQ9	Gene names	Pex6
Domain Architecture	No domain graphic available
Description	Peroxisome assembly factor 2 (PAF-2) (Peroxisomal-type ATPase 1) (Peroxin-6) (Peroxisomal biogenesis factor 6).

YMEL1_HUMAN
NC score	0.924669 (rank : 27)	θ value	2.42779e-29 (rank : 41)
Query Neighborhood Hits	85	Target Neighborhood Hits	73	Shared Neighborhood Hits	55
SwissProt Accessions	Q96TA2, Q9H1Q0, Q9UMR9	Gene names	YME1L1, FTSH1, YME1L
Domain Architecture
Description	ATP-dependent metalloprotease YME1L1 (EC 3.4.24.-) (YME1-like protein 1) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin- associated metalloprotease) (PAMP).

KATL1_MOUSE
NC score	0.920926 (rank : 28)	θ value	2.50655e-34 (rank : 25)
Query Neighborhood Hits	85	Target Neighborhood Hits	77	Shared Neighborhood Hits	57
SwissProt Accessions	Q8K0T4	Gene names	Katnal1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A-like 1 (EC 3.6.4.3) (Katanin p60 subunit A-like 1) (p60 katanin-like 1).

KATL1_HUMAN
NC score	0.920836 (rank : 29)	θ value	5.584e-34 (rank : 26)
Query Neighborhood Hits	85	Target Neighborhood Hits	80	Shared Neighborhood Hits	57
SwissProt Accessions	Q9BW62	Gene names	KATNAL1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A-like 1 (EC 3.6.4.3) (Katanin p60 subunit A-like 1) (p60 katanin-like 1).

NSF_MOUSE
NC score	0.919037 (rank : 30)	θ value	4.42448e-31 (rank : 34)
Query Neighborhood Hits	85	Target Neighborhood Hits	73	Shared Neighborhood Hits	57
SwissProt Accessions	P46460	Gene names	Nsf, Skd2
Domain Architecture
Description	Vesicle-fusing ATPase (EC 3.6.4.6) (Vesicular-fusion protein NSF) (N- ethylmaleimide sensitive fusion protein) (NEM-sensitive fusion protein) (SKD2 protein).

NSF_HUMAN
NC score	0.918163 (rank : 31)	θ value	8.3442e-30 (rank : 38)
Query Neighborhood Hits	85	Target Neighborhood Hits	74	Shared Neighborhood Hits	57
SwissProt Accessions	P46459, Q9UKZ2	Gene names	NSF
Domain Architecture
Description	Vesicle-fusing ATPase (EC 3.6.4.6) (Vesicular-fusion protein NSF) (N- ethylmaleimide sensitive fusion protein) (NEM-sensitive fusion protein).

KTNA1_HUMAN
NC score	0.918038 (rank : 32)	θ value	1.37539e-32 (rank : 28)
Query Neighborhood Hits	85	Target Neighborhood Hits	117	Shared Neighborhood Hits	57
SwissProt Accessions	O75449, Q5TFA8, Q5TFA9, Q86VN2, Q9NU52	Gene names	KATNA1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A1 (EC 3.6.4.3) (Katanin p60 subunit A1) (p60 katanin).

KTNA1_MOUSE
NC score	0.915946 (rank : 33)	θ value	1.16434e-31 (rank : 32)
Query Neighborhood Hits	85	Target Neighborhood Hits	123	Shared Neighborhood Hits	57
SwissProt Accessions	Q9WV86	Gene names	Katna1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A1 (EC 3.6.4.3) (Katanin p60 subunit A1) (p60 katanin) (Lipotransin).

SPAST_HUMAN
NC score	0.913810 (rank : 34)	θ value	1.6813e-30 (rank : 36)
Query Neighborhood Hits	85	Target Neighborhood Hits	100	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UBP0, Q9UPR9	Gene names	SPAST, KIAA1083, SPG4
Domain Architecture
Description	Spastin.

SPAST_MOUSE
NC score	0.912149 (rank : 35)	θ value	4.89182e-30 (rank : 37)
Query Neighborhood Hits	85	Target Neighborhood Hits	138	Shared Neighborhood Hits	58
SwissProt Accessions	Q9QYY8, Q6ZPY6, Q80VE0, Q9CVK0	Gene names	Spast, Kiaa1083, Spg4
Domain Architecture	No domain graphic available
Description	Spastin.

VPS4B_HUMAN
NC score	0.908298 (rank : 36)	θ value	1.79631e-32 (rank : 29)
Query Neighborhood Hits	85	Target Neighborhood Hits	87	Shared Neighborhood Hits	58
SwissProt Accessions	O75351, Q9GZS7	Gene names	VPS4B, SKD1, VPS42
Domain Architecture
Description	Vacuolar protein sorting-associating protein 4B (Protein SKD1).

VPS4B_MOUSE
NC score	0.908061 (rank : 37)	θ value	4.72714e-33 (rank : 27)
Query Neighborhood Hits	85	Target Neighborhood Hits	86	Shared Neighborhood Hits	58
SwissProt Accessions	P46467, Q91W22, Q9R1C9	Gene names	Vps4b, Skd1
Domain Architecture
Description	Vacuolar protein sorting-associating protein 4B (Protein SKD1).

VPS4A_HUMAN
NC score	0.904539 (rank : 38)	θ value	1.4233e-29 (rank : 39)
Query Neighborhood Hits	85	Target Neighborhood Hits	95	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UN37, Q8TF07, Q9UI03, Q9Y582	Gene names	VPS4A, VPS4
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associating protein 4A (SKD2 protein) (hVPS4) (VPS4-1).

VPS4A_MOUSE
NC score	0.904517 (rank : 39)	θ value	1.4233e-29 (rank : 40)
Query Neighborhood Hits	85	Target Neighborhood Hits	94	Shared Neighborhood Hits	58
SwissProt Accessions	Q8VEJ9, Q3TXT2	Gene names	Vps4a
Domain Architecture	No domain graphic available
Description	Vacuolar protein sorting-associating protein 4A.

ATAD2_MOUSE
NC score	0.888328 (rank : 40)	θ value	1.12514e-34 (rank : 23)
Query Neighborhood Hits	85	Target Neighborhood Hits	167	Shared Neighborhood Hits	57
SwissProt Accessions	Q8CDM1	Gene names	Atad2
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 2.

ATAD2_HUMAN
NC score	0.870927 (rank : 41)	θ value	1.9192e-34 (rank : 24)
Query Neighborhood Hits	85	Target Neighborhood Hits	322	Shared Neighborhood Hits	57
SwissProt Accessions	Q6PL18, Q658P2, Q68CQ0, Q6PJV6, Q8N890, Q9UHS5	Gene names	ATAD2
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 2.

FIGN_MOUSE
NC score	0.868300 (rank : 42)	θ value	3.39556e-23 (rank : 43)
Query Neighborhood Hits	85	Target Neighborhood Hits	165	Shared Neighborhood Hits	53
SwissProt Accessions	Q9ERZ6, Q3TPB0, Q3UP57, Q6PCM0	Gene names	Fign
Domain Architecture	No domain graphic available
Description	Fidgetin.

FIGN_HUMAN
NC score	0.863006 (rank : 43)	θ value	1.99067e-23 (rank : 42)
Query Neighborhood Hits	85	Target Neighborhood Hits	176	Shared Neighborhood Hits	53
SwissProt Accessions	Q5HY92, Q9H6M5, Q9NVZ9	Gene names	FIGN
Domain Architecture	No domain graphic available
Description	Fidgetin.

TRP13_MOUSE
NC score	0.709416 (rank : 44)	θ value	5.26297e-08 (rank : 47)
Query Neighborhood Hits	85	Target Neighborhood Hits	81	Shared Neighborhood Hits	52
SwissProt Accessions	Q3UA06, Q3UQG6, Q9CWW8	Gene names	Trip13
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 13 (Thyroid hormone receptor interactor 13) (Trip-13).

BCS1_HUMAN
NC score	0.705653 (rank : 45)	θ value	1.80886e-08 (rank : 45)
Query Neighborhood Hits	85	Target Neighborhood Hits	61	Shared Neighborhood Hits	50
SwissProt Accessions	Q9Y276, Q7Z2V7	Gene names	BCS1L, BCS1
Domain Architecture
Description	Mitochondrial chaperone BCS1 (BCS1-like protein) (H-BCS1).

TRP13_HUMAN
NC score	0.705368 (rank : 46)	θ value	1.17247e-07 (rank : 48)
Query Neighborhood Hits	85	Target Neighborhood Hits	81	Shared Neighborhood Hits	52
SwissProt Accessions	Q15645, O15324	Gene names	TRIP13
Domain Architecture	No domain graphic available
Description	Thyroid receptor-interacting protein 13 (Thyroid hormone receptor interactor 13) (Trip-13) (Human papillomavirus type 16 E1 protein- binding protein) (HPV16 E1 protein-binding protein) (16E1-BP).

BCS1_MOUSE
NC score	0.697096 (rank : 47)	θ value	3.08544e-08 (rank : 46)
Query Neighborhood Hits	85	Target Neighborhood Hits	64	Shared Neighborhood Hits	50
SwissProt Accessions	Q9CZP5	Gene names	Bcs1l
Domain Architecture
Description	Mitochondrial chaperone BCS1 (BCS1-like protein).

ATD3A_HUMAN
NC score	0.631246 (rank : 48)	θ value	1.99992e-07 (rank : 49)
Query Neighborhood Hits	85	Target Neighborhood Hits	248	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NVI7, Q8N275, Q96A50	Gene names	ATAD3A
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3A.

ATD3B_HUMAN
NC score	0.620991 (rank : 49)	θ value	3.41135e-07 (rank : 50)
Query Neighborhood Hits	85	Target Neighborhood Hits	340	Shared Neighborhood Hits	60
SwissProt Accessions	Q5T9A4, Q6ZRB5, Q9BUK4, Q9ULE7	Gene names	ATAD3B, KIAA1273
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3B.

ATAD3_MOUSE
NC score	0.614427 (rank : 50)	θ value	1.06045e-08 (rank : 44)
Query Neighborhood Hits	85	Target Neighborhood Hits	326	Shared Neighborhood Hits	61
SwissProt Accessions	Q925I1, Q3UE74, Q69ZM7, Q8C6C6	Gene names	Atad3, Atad3a, Kiaa1273
Domain Architecture	No domain graphic available
Description	ATPase family AAA domain-containing protein 3 (AAA-ATPase TOB3).

LONM_HUMAN
NC score	0.440910 (rank : 51)	θ value	0.00509761 (rank : 52)
Query Neighborhood Hits	85	Target Neighborhood Hits	130	Shared Neighborhood Hits	56
SwissProt Accessions	P36776, P36777, Q9UQ95	Gene names	PRSS15
Domain Architecture
Description	Lon protease homolog, mitochondrial precursor (EC 3.4.21.-) (Lon protease-like protein) (LONP) (LONHs).

CLPX_HUMAN
NC score	0.421666 (rank : 52)	θ value	0.21417 (rank : 59)
Query Neighborhood Hits	85	Target Neighborhood Hits	72	Shared Neighborhood Hits	52
SwissProt Accessions	O76031, Q9H4D9	Gene names	CLPX
Domain Architecture
Description	ATP-dependent Clp protease ATP-binding subunit ClpX-like, mitochondrial precursor.

CLPX_MOUSE
NC score	0.419682 (rank : 53)	θ value	0.21417 (rank : 60)
Query Neighborhood Hits	85	Target Neighborhood Hits	73	Shared Neighborhood Hits	52
SwissProt Accessions	Q9JHS4, Q9WVD1	Gene names	Clpx
Domain Architecture
Description	ATP-dependent Clp protease ATP-binding subunit ClpX-like, mitochondrial precursor.

RUVB1_HUMAN
NC score	0.309341 (rank : 54)	θ value	0.125558 (rank : 54)
Query Neighborhood Hits	85	Target Neighborhood Hits	78	Shared Neighborhood Hits	51
SwissProt Accessions	Q9Y265, Q9BSX9	Gene names	RUVBL1, NMP238, TIP49, TIP49A
Domain Architecture
Description	RuvB-like 1 (EC 3.6.1.-) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (TIP49a) (Pontin 52) (Nuclear matrix protein 238) (NMP 238) (54 kDa erythrocyte cytosolic protein) (ECP-54) (TIP60-associated protein 54-alpha) (TAP54-alpha).

RUVB1_MOUSE
NC score	0.309302 (rank : 55)	θ value	0.125558 (rank : 55)
Query Neighborhood Hits	85	Target Neighborhood Hits	78	Shared Neighborhood Hits	51
SwissProt Accessions	P60122, O35753	Gene names	Ruvbl1, Tip49, Tip49a
Domain Architecture
Description	RuvB-like 1 (EC 3.6.1.-) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (TIP49a) (Pontin 52) (DNA helicase p50).

WRIP1_MOUSE
NC score	0.268067 (rank : 56)	θ value	0.00175202 (rank : 51)
Query Neighborhood Hits	85	Target Neighborhood Hits	93	Shared Neighborhood Hits	46
SwissProt Accessions	Q91XU0, Q3TCT7, Q6PDF0, Q8BUW5, Q8BWP6, Q8BY55, Q921W3, Q9EQL3	Gene names	Wrnip1, Whip
Domain Architecture	No domain graphic available
Description	ATPase WRNIP1 (Werner helicase-interacting protein 1).

WRIP1_HUMAN
NC score	0.263845 (rank : 57)	θ value	0.00869519 (rank : 53)
Query Neighborhood Hits	85	Target Neighborhood Hits	100	Shared Neighborhood Hits	47
SwissProt Accessions	Q96S55, Q53EP6, Q59ET8, Q5W0E2, Q5W0E4, Q8WV26, Q9H681, Q9NRJ6	Gene names	WRNIP1, WHIP
Domain Architecture	No domain graphic available
Description	ATPase WRNIP1 (Werner helicase-interacting protein 1).

RUVB2_HUMAN
NC score	0.112541 (rank : 58)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	85	Target Neighborhood Hits	43	Shared Neighborhood Hits	36
SwissProt Accessions	Q9Y230, Q6PK27, Q9Y361	Gene names	RUVBL2, TIP48, TIP49B
Domain Architecture
Description	RuvB-like 2 (EC 3.6.1.-) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (TIP49b) (Repressing pontin 52) (Reptin 52) (51 kDa erythrocyte cytosolic protein) (ECP-51) (TIP60-associated protein 54-beta) (TAP54-beta).

RUVB2_MOUSE
NC score	0.110014 (rank : 59)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	85	Target Neighborhood Hits	42	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WTM5	Gene names	Ruvbl2
Domain Architecture
Description	RuvB-like 2 (EC 3.6.1.-) (p47 protein).

RFC1_MOUSE
NC score	0.106348 (rank : 60)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	85	Target Neighborhood Hits	290	Shared Neighborhood Hits	42
SwissProt Accessions	P35601	Gene names	Rfc1, Ibf-1, Recc1
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (A1-P145) (Differentiation- specific element-binding protein) (ISRE-binding protein).

THNSL_MOUSE
NC score	0.098340 (rank : 61)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	85	Target Neighborhood Hits	47	Shared Neighborhood Hits	28
SwissProt Accessions	Q8BH55	Gene names	Thnsl1
Domain Architecture	No domain graphic available
Description	Threonine synthase-like 1.

THNSL_HUMAN
NC score	0.095378 (rank : 62)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	85	Target Neighborhood Hits	47	Shared Neighborhood Hits	31
SwissProt Accessions	Q8IYQ7, Q5VV21	Gene names	THNSL1
Domain Architecture	No domain graphic available
Description	Threonine synthase-like 1.

RFC1_HUMAN
NC score	0.092651 (rank : 63)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	85	Target Neighborhood Hits	352	Shared Neighborhood Hits	37
SwissProt Accessions	P35251, Q5XKF5, Q6PKU0, Q86V41, Q86V46	Gene names	RFC1, RFC140
Domain Architecture
Description	Replication factor C subunit 1 (Replication factor C large subunit) (RF-C 140 kDa subunit) (Activator 1 140 kDa subunit) (Activator 1 large subunit) (A1 140 kDa subunit) (DNA-binding protein PO-GA).

RFC4_HUMAN
NC score	0.092199 (rank : 64)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	85	Target Neighborhood Hits	64	Shared Neighborhood Hits	34
SwissProt Accessions	P35249, Q6FHX7	Gene names	RFC4
Domain Architecture
Description	Replication factor C subunit 4 (Replication factor C 37 kDa subunit) (RF-C 37 kDa subunit) (RFC37) (Activator 1 37 kDa subunit) (A1 37 kDa subunit).

KAD6_HUMAN
NC score	0.090267 (rank : 65)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	85	Target Neighborhood Hits	46	Shared Neighborhood Hits	24
SwissProt Accessions	Q9Y3D8	Gene names	AK6
Domain Architecture
Description	Adenylate kinase isoenzyme 6 (EC 2.7.4.3) (ATP-AMP transphosphorylase 6).

RFC4_MOUSE
NC score	0.081594 (rank : 66)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	85	Target Neighborhood Hits	65	Shared Neighborhood Hits	34
SwissProt Accessions	Q99J62	Gene names	Rfc4
Domain Architecture	No domain graphic available
Description	Replication factor C subunit 4.

KAD6_MOUSE
NC score	0.069535 (rank : 67)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	85	Target Neighborhood Hits	34	Shared Neighborhood Hits	18
SwissProt Accessions	Q8VCP8	Gene names	Ak6
Domain Architecture	No domain graphic available
Description	Adenylate kinase isoenzyme 6 (EC 2.7.4.3) (ATP-AMP transphosphorylase 6).

RFC5_MOUSE
NC score	0.065303 (rank : 68)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	85	Target Neighborhood Hits	58	Shared Neighborhood Hits	28
SwissProt Accessions	Q9D0F6	Gene names	Rfc5
Domain Architecture
Description	Replication factor C subunit 5 (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36) (Activator 1 36 kDa subunit) (A1 36 kDa subunit).

RFC5_HUMAN
NC score	0.064522 (rank : 69)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	85	Target Neighborhood Hits	60	Shared Neighborhood Hits	26
SwissProt Accessions	P40937	Gene names	RFC5
Domain Architecture
Description	Replication factor C subunit 5 (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36) (Activator 1 36 kDa subunit) (A1 36 kDa subunit).

LSD1_MOUSE
NC score	0.032522 (rank : 70)	θ value	0.21417 (rank : 62)
Query Neighborhood Hits	85	Target Neighborhood Hits	224	Shared Neighborhood Hits	11
SwissProt Accessions	Q6ZQ88, Q6PB53, Q8VEA1	Gene names	Aof2, Kiaa0601, Lsd1
Domain Architecture	No domain graphic available
Description	Lysine-specific histone demethylase 1 (EC 1.-.-.-) (Flavin-containing amine oxidase domain-containing protein 2) (BRAF35-HDAC complex protein BHC110).

LSD1_HUMAN
NC score	0.029262 (rank : 71)	θ value	0.21417 (rank : 61)
Query Neighborhood Hits	85	Target Neighborhood Hits	455	Shared Neighborhood Hits	11
SwissProt Accessions	O60341, Q5TH94, Q5TH95, Q86VT7, Q8IXK4, Q8NDP6, Q8TAZ3, Q96AW4	Gene names	AOF2, KIAA0601, LSD1
Domain Architecture	No domain graphic available
Description	Lysine-specific histone demethylase 1 (EC 1.-.-.-) (Flavin-containing amine oxidase domain-containing protein 2) (BRAF35-HDAC complex protein BHC110).

CLPB_HUMAN
NC score	0.025465 (rank : 72)	θ value	0.47712 (rank : 63)
Query Neighborhood Hits	85	Target Neighborhood Hits	265	Shared Neighborhood Hits	6
SwissProt Accessions	Q9H078, Q8ND11, Q9H8Y0	Gene names	CLPB, SKD3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

CFLAR_MOUSE
NC score	0.022001 (rank : 73)	θ value	1.06291 (rank : 66)
Query Neighborhood Hits	85	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	O35732, O35707, O35733	Gene names	Cflar, Cash
Domain Architecture
Description	CASP8 and FADD-like apoptosis regulator precursor (Cellular FLICE-like inhibitory protein) (c-FLIP) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (MACH-related inducer of toxicity) (MRIT) (Caspase homolog) (CASH) (Inhibitor of FLICE) (I-FLICE) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Usurpin) [Contains: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12].

CLPB_MOUSE
NC score	0.020356 (rank : 74)	θ value	0.62314 (rank : 65)
Query Neighborhood Hits	85	Target Neighborhood Hits	289	Shared Neighborhood Hits	6
SwissProt Accessions	Q60649	Gene names	Clpb, Skd3
Domain Architecture
Description	Caseinolytic peptidase B protein homolog (Suppressor of potassium transport defect 3).

HSF2_HUMAN
NC score	0.017647 (rank : 75)	θ value	2.36792 (rank : 67)
Query Neighborhood Hits	85	Target Neighborhood Hits	149	Shared Neighborhood Hits	7
SwissProt Accessions	Q03933, Q9H445	Gene names	HSF2, HSTF2
Domain Architecture
Description	Heat shock factor protein 2 (HSF 2) (Heat shock transcription factor 2) (HSTF 2).

HSF2_MOUSE
NC score	0.017578 (rank : 76)	θ value	2.36792 (rank : 68)
Query Neighborhood Hits	85	Target Neighborhood Hits	153	Shared Neighborhood Hits	7
SwissProt Accessions	P38533, Q64157, Q8VEJ0, Q9Z2L8	Gene names	Hsf2
Domain Architecture
Description	Heat shock factor protein 2 (HSF 2) (Heat shock transcription factor 2) (HSTF 2).

U334_MOUSE
NC score	0.015935 (rank : 77)	θ value	5.27518 (rank : 75)
Query Neighborhood Hits	85	Target Neighborhood Hits	5	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CQA9	Gene names
Domain Architecture	No domain graphic available
Description	Probable UPF0334 kinase-like protein C1orf57 homolog.

STAT2_MOUSE
NC score	0.011097 (rank : 78)	θ value	0.163984 (rank : 58)
Query Neighborhood Hits	85	Target Neighborhood Hits	175	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WVL2, Q64188, Q64189, Q64250	Gene names	Stat2
Domain Architecture
Description	Signal transducer and activator of transcription 2.

SYCP1_MOUSE
NC score	0.011095 (rank : 79)	θ value	0.125558 (rank : 56)
Query Neighborhood Hits	85	Target Neighborhood Hits	1456	Shared Neighborhood Hits	18
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

CCD41_MOUSE
NC score	0.008848 (rank : 80)	θ value	0.163984 (rank : 57)
Query Neighborhood Hits	85	Target Neighborhood Hits	1399	Shared Neighborhood Hits	21
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

TACC2_HUMAN
NC score	0.008788 (rank : 81)	θ value	6.88961 (rank : 78)
Query Neighborhood Hits	85	Target Neighborhood Hits	856	Shared Neighborhood Hits	18
SwissProt Accessions	O95359, Q9NZ41, Q9NZR5	Gene names	TACC2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2 (Anti Zuai-1) (AZU-1).

TACC2_MOUSE
NC score	0.008580 (rank : 82)	θ value	6.88961 (rank : 79)
Query Neighborhood Hits	85	Target Neighborhood Hits	774	Shared Neighborhood Hits	17
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

SYNE1_HUMAN
NC score	0.007780 (rank : 83)	θ value	0.47712 (rank : 64)
Query Neighborhood Hits	85	Target Neighborhood Hits	1484	Shared Neighborhood Hits	21
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

CASP_HUMAN
NC score	0.007210 (rank : 84)	θ value	4.03905 (rank : 71)
Query Neighborhood Hits	85	Target Neighborhood Hits	1131	Shared Neighborhood Hits	22
SwissProt Accessions	Q13948, Q53GU9, Q8TBS3	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Protein CASP.

VPP1_HUMAN
NC score	0.007016 (rank : 85)	θ value	8.99809 (rank : 84)
Query Neighborhood Hits	85	Target Neighborhood Hits	28	Shared Neighborhood Hits	5
SwissProt Accessions	Q93050, Q8N5G7, Q9NSX0	Gene names	ATP6V0A1, ATP6N1, VPP1
Domain Architecture
Description	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1 (V- ATPase 116 kDa isoform a1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar proton pump subunit 1) (Vacuolar adenosine triphosphatase subunit Ac116).

VPP1_MOUSE
NC score	0.006843 (rank : 86)	θ value	8.99809 (rank : 85)
Query Neighborhood Hits	85	Target Neighborhood Hits	26	Shared Neighborhood Hits	4
SwissProt Accessions	Q9Z1G4, Q9JHJ4, Q9JL13, Q9JL14	Gene names	Atp6v0a1, Atp6n1
Domain Architecture
Description	Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1 (V- ATPase 116 kDa isoform a1) (Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit) (Vacuolar proton pump subunit 1) (Vacuolar adenosine triphosphatase subunit Ac116).

NIN_MOUSE
NC score	0.006617 (rank : 87)	θ value	3.0926 (rank : 69)
Query Neighborhood Hits	85	Target Neighborhood Hits	1376	Shared Neighborhood Hits	21
SwissProt Accessions	Q61043, Q6ZPM7	Gene names	Nin, Kiaa1565
Domain Architecture	No domain graphic available
Description	Ninein.

PK2L2_HUMAN
NC score	0.006356 (rank : 88)	θ value	5.27518 (rank : 74)
Query Neighborhood Hits	85	Target Neighborhood Hits	90	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

CUTL1_HUMAN
NC score	0.005834 (rank : 89)	θ value	4.03905 (rank : 72)
Query Neighborhood Hits	85	Target Neighborhood Hits	1574	Shared Neighborhood Hits	24
SwissProt Accessions	P39880, Q6NYH4, Q9UEV5	Gene names	CUTL1
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP).

NIN_HUMAN
NC score	0.005745 (rank : 90)	θ value	5.27518 (rank : 73)
Query Neighborhood Hits	85	Target Neighborhood Hits	1416	Shared Neighborhood Hits	23
SwissProt Accessions	Q8N4C6, Q6P0P6, Q9BWU6, Q9C012, Q9C013, Q9C014, Q9H5I6, Q9HAT7, Q9HBY5, Q9HCK7, Q9UH61	Gene names	NIN, KIAA1565
Domain Architecture	No domain graphic available
Description	Ninein (hNinein) (Glycogen synthase kinase 3 beta-interacting protein) (GSK3B-interacting protein).

TACC1_MOUSE
NC score	0.005274 (rank : 91)	θ value	8.99809 (rank : 83)
Query Neighborhood Hits	85	Target Neighborhood Hits	667	Shared Neighborhood Hits	16
SwissProt Accessions	Q6Y685, Q6Y686	Gene names	Tacc1
Domain Architecture	No domain graphic available
Description	Transforming acidic coiled-coil-containing protein 1.

ULK3_MOUSE
NC score	0.002127 (rank : 92)	θ value	6.88961 (rank : 80)
Query Neighborhood Hits	85	Target Neighborhood Hits	872	Shared Neighborhood Hits	10
SwissProt Accessions	Q3U3Q1, Q8K1X6, Q9DBR8	Gene names	Ulk3
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase ULK3 (EC 2.7.11.1) (Unc-51-like kinase 3).

KIF5C_HUMAN
NC score	0.001324 (rank : 93)	θ value	8.99809 (rank : 81)
Query Neighborhood Hits	85	Target Neighborhood Hits	974	Shared Neighborhood Hits	18
SwissProt Accessions	O60282, O95079	Gene names	KIF5C, KIAA0531, NKHC2
Domain Architecture	No domain graphic available
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

KIF5C_MOUSE
NC score	0.000993 (rank : 94)	θ value	8.99809 (rank : 82)
Query Neighborhood Hits	85	Target Neighborhood Hits	1040	Shared Neighborhood Hits	16
SwissProt Accessions	P28738, Q9Z2F8	Gene names	Kif5c, Nkhc2
Domain Architecture
Description	Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2).

ROCK1_HUMAN
NC score	-0.003399 (rank : 95)	θ value	6.88961 (rank : 76)
Query Neighborhood Hits	85	Target Neighborhood Hits	2000	Shared Neighborhood Hits	22
SwissProt Accessions	Q13464	Gene names	ROCK1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK) (NY-REN-35 antigen).

ROCK1_MOUSE
NC score	-0.003407 (rank : 96)	θ value	6.88961 (rank : 77)
Query Neighborhood Hits	85	Target Neighborhood Hits	2126	Shared Neighborhood Hits	24
SwissProt Accessions	P70335, Q8C3G4, Q8C7H0	Gene names	Rock1
Domain Architecture
Description	Rho-associated protein kinase 1 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 1) (p160 ROCK-1) (p160ROCK).

RIPK1_HUMAN
NC score	-0.003940 (rank : 97)	θ value	3.0926 (rank : 70)
Query Neighborhood Hits	85	Target Neighborhood Hits	891	Shared Neighborhood Hits	6
SwissProt Accessions	Q13546, Q13180	Gene names	RIPK1, RIP
Domain Architecture
Description	Receptor-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (Serine/threonine-protein kinase RIP) (Cell death protein RIP) (Receptor-interacting protein).