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Network neighborhood for query Sequence : TSC2_MOUSE

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TSC2_MOUSE
SwissProt Accessions	Q61037, P97723, P97724, P97725, P97727, Q61007, Q61008, Q9WUF6	Gene names	Tsc2
Domain Architecture
Description	Tuberin (Tuberous sclerosis 2 homolog protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TSC2_HUMAN
θ value	0 (rank : 1)	NC score	0.991071 (rank : 2)
Query Neighborhood Hits	48	Target Neighborhood Hits	59	Shared Neighborhood Hits	17
SwissProt Accessions	P49815, O75275, Q8TAZ1	Gene names	TSC2
Domain Architecture
Description	Tuberin (Tuberous sclerosis 2 protein).

TSC2_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	48	Target Neighborhood Hits	48	Shared Neighborhood Hits	48
SwissProt Accessions	Q61037, P97723, P97724, P97725, P97727, Q61007, Q61008, Q9WUF6	Gene names	Tsc2
Domain Architecture
Description	Tuberin (Tuberous sclerosis 2 homolog protein).

GRIPE_HUMAN
θ value	1.24977e-17 (rank : 3)	NC score	0.509368 (rank : 4)
Query Neighborhood Hits	48	Target Neighborhood Hits	69	Shared Neighborhood Hits	12
SwissProt Accessions	Q6GYQ0, O94960, Q6GYP9, Q6ZT23, Q86YF3, Q86YF5, Q8ND69	Gene names	GARNL1, KIAA0884, TULIP1
Domain Architecture	No domain graphic available
Description	GTPase-activating Rap/Ran-GAP domain-like 1 (GAP-related-interacting partner to E12) (GRIPE) (Tuberin-like protein 1).

GRIPE_MOUSE
θ value	2.13179e-17 (rank : 4)	NC score	0.507090 (rank : 5)
Query Neighborhood Hits	48	Target Neighborhood Hits	70	Shared Neighborhood Hits	12
SwissProt Accessions	Q6GYP7, Q6GYP6, Q6ZQ28, Q8BNJ5, Q8C9G8, Q8CIW4, Q9JMC4	Gene names	Garnl1, Kiaa0884, Tulip1
Domain Architecture	No domain graphic available
Description	GTPase-activating RapGAP domain-like 1 (GAP-related-interacting partner to E12) (GRIPE) (Tuberin-like protein 1).

RGP2_HUMAN
θ value	1.2105e-12 (rank : 5)	NC score	0.512755 (rank : 3)
Query Neighborhood Hits	48	Target Neighborhood Hits	60	Shared Neighborhood Hits	12
SwissProt Accessions	P47736	Gene names	RAP1GAP, RAP1GA1
Domain Architecture
Description	Rap1 GTPase-activating protein 1 (Rap1GAP).

SI1L3_HUMAN
θ value	2.13673e-09 (rank : 6)	NC score	0.411422 (rank : 10)
Query Neighborhood Hits	48	Target Neighborhood Hits	305	Shared Neighborhood Hits	15
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

SIPA1_HUMAN
θ value	2.13673e-09 (rank : 7)	NC score	0.421090 (rank : 7)
Query Neighborhood Hits	48	Target Neighborhood Hits	250	Shared Neighborhood Hits	16
SwissProt Accessions	Q96FS4, O14518, O60484, O60618	Gene names	SIPA1, SPA1
Domain Architecture
Description	Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase- activating protein Spa-1) (p130 SPA-1).

SI1L2_HUMAN
θ value	3.64472e-09 (rank : 8)	NC score	0.415448 (rank : 8)
Query Neighborhood Hits	48	Target Neighborhood Hits	131	Shared Neighborhood Hits	13
SwissProt Accessions	Q9P2F8, Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6	Gene names	SIPA1L2, KIAA1389
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

SI1L2_MOUSE
θ value	3.64472e-09 (rank : 9)	NC score	0.415387 (rank : 9)
Query Neighborhood Hits	48	Target Neighborhood Hits	124	Shared Neighborhood Hits	14
SwissProt Accessions	Q80TE4, Q6PDY1	Gene names	Sipa1l2, Kiaa0545
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

SI1L1_HUMAN
θ value	1.06045e-08 (rank : 10)	NC score	0.410810 (rank : 11)
Query Neighborhood Hits	48	Target Neighborhood Hits	162	Shared Neighborhood Hits	13
SwissProt Accessions	O43166, O95321, Q9UDU4, Q9UNU4	Gene names	SIPA1L1, E6TP1, KIAA0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1 (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6- targeted protein 1).

SI1L1_MOUSE
θ value	1.06045e-08 (rank : 11)	NC score	0.409614 (rank : 12)
Query Neighborhood Hits	48	Target Neighborhood Hits	189	Shared Neighborhood Hits	13
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

SIPA1_MOUSE
θ value	1.38499e-08 (rank : 12)	NC score	0.423628 (rank : 6)
Query Neighborhood Hits	48	Target Neighborhood Hits	158	Shared Neighborhood Hits	13
SwissProt Accessions	P46062, P70204	Gene names	Sipa1, Spa-1, Spa1
Domain Architecture
Description	Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase- activating protein Spa-1).

HD_MOUSE
θ value	0.0330416 (rank : 13)	NC score	0.054327 (rank : 16)
Query Neighborhood Hits	48	Target Neighborhood Hits	116	Shared Neighborhood Hits	2
SwissProt Accessions	P42859	Gene names	Hd, Hdh
Domain Architecture
Description	Huntingtin (Huntington disease protein homolog) (HD protein).

ARI5B_HUMAN
θ value	0.163984 (rank : 14)	NC score	0.040525 (rank : 19)
Query Neighborhood Hits	48	Target Neighborhood Hits	328	Shared Neighborhood Hits	2
SwissProt Accessions	Q14865, Q7Z3M4, Q8N421, Q9H786	Gene names	ARID5B, DESRT, MRF2
Domain Architecture
Description	AT-rich interactive domain-containing protein 5B (ARID domain- containing protein 5B) (Mrf1-like) (Modulator recognition factor 2) (MRF-2).

VPS35_MOUSE
θ value	0.365318 (rank : 15)	NC score	0.057976 (rank : 14)
Query Neighborhood Hits	48	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	Q9EQH3, Q61123	Gene names	Vps35, Mem3
Domain Architecture
Description	Vacuolar protein sorting-associated protein 35 (Vesicle protein sorting 35) (Maternal-embryonic 3).

MAVS_HUMAN
θ value	0.47712 (rank : 16)	NC score	0.042011 (rank : 18)
Query Neighborhood Hits	48	Target Neighborhood Hits	271	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z434, Q3I0Y2, Q5T7I6, Q86VY7, Q9H1H3, Q9H4Y1, Q9H8D3, Q9ULE9	Gene names	MAVS, IPS1, KIAA1271, VISA
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif) (Putative NF-kappa-B- activating protein 031N).

FANCE_HUMAN
θ value	0.813845 (rank : 17)	NC score	0.100384 (rank : 13)
Query Neighborhood Hits	48	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HB96, Q4ZGH2	Gene names	FANCE
Domain Architecture	No domain graphic available
Description	Fanconi anemia group E protein (Protein FACE).

PK1L1_HUMAN
θ value	0.813845 (rank : 18)	NC score	0.034995 (rank : 21)
Query Neighborhood Hits	48	Target Neighborhood Hits	140	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TDX9, Q6UWK1	Gene names	PKD1L1
Domain Architecture
Description	Polycystic kidney disease 1-like 1 protein (Polycystin-1L1).

MAGI1_HUMAN
θ value	1.06291 (rank : 19)	NC score	0.020712 (rank : 24)
Query Neighborhood Hits	48	Target Neighborhood Hits	388	Shared Neighborhood Hits	10
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAST2_MOUSE
θ value	1.06291 (rank : 20)	NC score	0.007015 (rank : 39)
Query Neighborhood Hits	48	Target Neighborhood Hits	1110	Shared Neighborhood Hits	11
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

STK23_MOUSE
θ value	1.06291 (rank : 21)	NC score	0.018720 (rank : 27)
Query Neighborhood Hits	48	Target Neighborhood Hits	572	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z0G2	Gene names	Stk23, Mssk1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

VPS35_HUMAN
θ value	1.06291 (rank : 22)	NC score	0.052638 (rank : 17)
Query Neighborhood Hits	48	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	Q96QK1, Q561W2, Q9H016, Q9H096, Q9H4P3, Q9H8J0, Q9NRS7, Q9NVG2, Q9NX80, Q9NZK2	Gene names	VPS35, MEM3
Domain Architecture
Description	Vacuolar protein sorting-associated protein 35 (Vesicle protein sorting 35) (hVPS35) (Maternal-embryonic 3).

PARM1_HUMAN
θ value	1.38821 (rank : 23)	NC score	0.038665 (rank : 20)
Query Neighborhood Hits	48	Target Neighborhood Hits	86	Shared Neighborhood Hits	2
SwissProt Accessions	Q6UWI2, Q96DV8, Q9Y4S1	Gene names	ames=UNQ1879/PRO4322
Domain Architecture	No domain graphic available
Description	Protein PARM-1 precursor.

MAST2_HUMAN
θ value	3.0926 (rank : 24)	NC score	0.006359 (rank : 42)
Query Neighborhood Hits	48	Target Neighborhood Hits	1189	Shared Neighborhood Hits	11
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

CJ067_HUMAN
θ value	4.03905 (rank : 25)	NC score	0.055096 (rank : 15)
Query Neighborhood Hits	48	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IYJ2, Q5SWD4	Gene names	C10orf67
Domain Architecture	No domain graphic available
Description	Protein C10orf67.

FOXH1_MOUSE
θ value	4.03905 (rank : 26)	NC score	0.010118 (rank : 34)
Query Neighborhood Hits	48	Target Neighborhood Hits	118	Shared Neighborhood Hits	3
SwissProt Accessions	O88621, Q9QZL5, Q9R241	Gene names	Foxh1, Fast1, Fast2
Domain Architecture
Description	Forkhead box protein H1 (Forkhead activin signal transducer 1) (Fast- 1) (Forkhead activin signal transducer 2) (Fast-2).

GPR22_HUMAN
θ value	4.03905 (rank : 27)	NC score	0.013107 (rank : 30)
Query Neighborhood Hits	48	Target Neighborhood Hits	301	Shared Neighborhood Hits	2
SwissProt Accessions	Q99680, O14554	Gene names	GPR22
Domain Architecture
Description	Probable G-protein coupled receptor 22.

CNTN6_MOUSE
θ value	5.27518 (rank : 28)	NC score	0.003134 (rank : 47)
Query Neighborhood Hits	48	Target Neighborhood Hits	429	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JMB8, Q8C6X1	Gene names	Cntn6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (mNB-3).

DYH5_HUMAN
θ value	5.27518 (rank : 29)	NC score	0.009549 (rank : 35)
Query Neighborhood Hits	48	Target Neighborhood Hits	323	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TE73, Q92860, Q96L74, Q9H5S7, Q9HCG9	Gene names	DNAH5, DNAHC5, KIAA1603
Domain Architecture	No domain graphic available
Description	Ciliary dynein heavy chain 5 (Axonemal beta dynein heavy chain 5) (HL1).

TCF19_MOUSE
θ value	5.27518 (rank : 30)	NC score	0.021508 (rank : 23)
Query Neighborhood Hits	48	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q99KJ5, Q8BPA3, Q9CT93	Gene names	Tcf19, Sc1
Domain Architecture
Description	Transcription factor 19-like protein (SC1 protein homolog).

GR65_HUMAN
θ value	6.88961 (rank : 31)	NC score	0.012548 (rank : 31)
Query Neighborhood Hits	48	Target Neighborhood Hits	148	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BQQ3, Q8N272, Q96H42	Gene names	GORASP1, GRASP65
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 1 (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5).

IASPP_MOUSE
θ value	6.88961 (rank : 32)	NC score	0.004294 (rank : 46)
Query Neighborhood Hits	48	Target Neighborhood Hits	1024	Shared Neighborhood Hits	2
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

KLC1_HUMAN
θ value	6.88961 (rank : 33)	NC score	0.006734 (rank : 40)
Query Neighborhood Hits	48	Target Neighborhood Hits	471	Shared Neighborhood Hits	4
SwissProt Accessions	Q07866, Q7RTM2, Q7RTM3, Q7RTM5, Q7RTP9, Q7RTQ5, Q86SF5, Q86TF5, Q86V74, Q86V75, Q86V76, Q86V77, Q86V78, Q86V79, Q96H62	Gene names	KNS2, KLC, KLC1
Domain Architecture
Description	Kinesin light chain 1 (KLC 1).

NIBA_HUMAN
θ value	6.88961 (rank : 34)	NC score	0.014344 (rank : 28)
Query Neighborhood Hits	48	Target Neighborhood Hits	84	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BZQ8, Q5TEM8, Q8TEI5, Q9H593, Q9H9Y8, Q9HCB9	Gene names	C1orf24
Domain Architecture	No domain graphic available
Description	Niban protein.

PER3_HUMAN
θ value	6.88961 (rank : 35)	NC score	0.008675 (rank : 36)
Query Neighborhood Hits	48	Target Neighborhood Hits	479	Shared Neighborhood Hits	5
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

PRR6_MOUSE
θ value	6.88961 (rank : 36)	NC score	0.019184 (rank : 26)
Query Neighborhood Hits	48	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CXS4, Q5SX21, Q6PIA5	Gene names	Prr6
Domain Architecture	No domain graphic available
Description	Proline-rich protein 6.

TEX10_HUMAN
θ value	6.88961 (rank : 37)	NC score	0.020587 (rank : 25)
Query Neighborhood Hits	48	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NXF1, Q5T722, Q5T723, Q8NCN8, Q8TDY0	Gene names	TEX10
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 10 protein.

CAN11_HUMAN
θ value	8.99809 (rank : 38)	NC score	0.004526 (rank : 45)
Query Neighborhood Hits	48	Target Neighborhood Hits	63	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UMQ6, Q8N4R5	Gene names	CAPN11
Domain Architecture
Description	Calpain-11 (EC 3.4.22.-) (Calcium-activated neutral proteinase 11) (CANP 11).

CTDP1_MOUSE
θ value	8.99809 (rank : 39)	NC score	0.032565 (rank : 22)
Query Neighborhood Hits	48	Target Neighborhood Hits	146	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TSG2, Q7TSS7, Q9D4S8	Gene names	Ctdp1, Fcp1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

CTRO_MOUSE
θ value	8.99809 (rank : 40)	NC score	0.000087 (rank : 48)
Query Neighborhood Hits	48	Target Neighborhood Hits	2344	Shared Neighborhood Hits	10
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).

DFNA5_MOUSE
θ value	8.99809 (rank : 41)	NC score	0.011748 (rank : 32)
Query Neighborhood Hits	48	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z2D3	Gene names	Dfna5, Dfna5h
Domain Architecture
Description	Non-syndromic hearing impairment protein 5 homolog.

ELF1_MOUSE
θ value	8.99809 (rank : 42)	NC score	0.005867 (rank : 43)
Query Neighborhood Hits	48	Target Neighborhood Hits	139	Shared Neighborhood Hits	3
SwissProt Accessions	Q60775	Gene names	Elf1
Domain Architecture
Description	ETS-related transcription factor Elf-1 (E74-like factor 1).

FOXI1_HUMAN
θ value	8.99809 (rank : 43)	NC score	0.004833 (rank : 44)
Query Neighborhood Hits	48	Target Neighborhood Hits	104	Shared Neighborhood Hits	3
SwissProt Accessions	Q12951, Q14518, Q66SR7, Q8N6L8	Gene names	FOXI1, FKHL10, FREAC6
Domain Architecture
Description	Forkhead box protein I1 (Forkhead-related protein FKHL10) (Forkhead- related transcription factor 6) (FREAC-6) (Hepatocyte nuclear factor 3 forkhead homolog 3) (HNF-3/fork-head homolog 3) (HFH-3).

HAIR_HUMAN
θ value	8.99809 (rank : 44)	NC score	0.008334 (rank : 37)
Query Neighborhood Hits	48	Target Neighborhood Hits	172	Shared Neighborhood Hits	2
SwissProt Accessions	O43593, Q96H33, Q9NPE1	Gene names	HR
Domain Architecture
Description	Protein hairless.

LUZP1_MOUSE
θ value	8.99809 (rank : 45)	NC score	0.006521 (rank : 41)
Query Neighborhood Hits	48	Target Neighborhood Hits	940	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

MARCS_MOUSE
θ value	8.99809 (rank : 46)	NC score	0.010764 (rank : 33)
Query Neighborhood Hits	48	Target Neighborhood Hits	227	Shared Neighborhood Hits	3
SwissProt Accessions	P26645	Gene names	Marcks, Macs
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS).

SRBP1_MOUSE
θ value	8.99809 (rank : 47)	NC score	0.007972 (rank : 38)
Query Neighborhood Hits	48	Target Neighborhood Hits	384	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

TAF6_HUMAN
θ value	8.99809 (rank : 48)	NC score	0.014260 (rank : 29)
Query Neighborhood Hits	48	Target Neighborhood Hits	127	Shared Neighborhood Hits	6
SwissProt Accessions	P49848	Gene names	TAF6, TAF2E, TAFII70
Domain Architecture
Description	Transcription initiation factor TFIID subunit 6 (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII- 80) (TAFII80).

Hits sorted by NC score

TSC2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	48	Target Neighborhood Hits	48	Shared Neighborhood Hits	48
SwissProt Accessions	Q61037, P97723, P97724, P97725, P97727, Q61007, Q61008, Q9WUF6	Gene names	Tsc2
Domain Architecture
Description	Tuberin (Tuberous sclerosis 2 homolog protein).

TSC2_HUMAN
NC score	0.991071 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	48	Target Neighborhood Hits	59	Shared Neighborhood Hits	17
SwissProt Accessions	P49815, O75275, Q8TAZ1	Gene names	TSC2
Domain Architecture
Description	Tuberin (Tuberous sclerosis 2 protein).

RGP2_HUMAN
NC score	0.512755 (rank : 3)	θ value	1.2105e-12 (rank : 5)
Query Neighborhood Hits	48	Target Neighborhood Hits	60	Shared Neighborhood Hits	12
SwissProt Accessions	P47736	Gene names	RAP1GAP, RAP1GA1
Domain Architecture
Description	Rap1 GTPase-activating protein 1 (Rap1GAP).

GRIPE_HUMAN
NC score	0.509368 (rank : 4)	θ value	1.24977e-17 (rank : 3)
Query Neighborhood Hits	48	Target Neighborhood Hits	69	Shared Neighborhood Hits	12
SwissProt Accessions	Q6GYQ0, O94960, Q6GYP9, Q6ZT23, Q86YF3, Q86YF5, Q8ND69	Gene names	GARNL1, KIAA0884, TULIP1
Domain Architecture	No domain graphic available
Description	GTPase-activating Rap/Ran-GAP domain-like 1 (GAP-related-interacting partner to E12) (GRIPE) (Tuberin-like protein 1).

GRIPE_MOUSE
NC score	0.507090 (rank : 5)	θ value	2.13179e-17 (rank : 4)
Query Neighborhood Hits	48	Target Neighborhood Hits	70	Shared Neighborhood Hits	12
SwissProt Accessions	Q6GYP7, Q6GYP6, Q6ZQ28, Q8BNJ5, Q8C9G8, Q8CIW4, Q9JMC4	Gene names	Garnl1, Kiaa0884, Tulip1
Domain Architecture	No domain graphic available
Description	GTPase-activating RapGAP domain-like 1 (GAP-related-interacting partner to E12) (GRIPE) (Tuberin-like protein 1).

SIPA1_MOUSE
NC score	0.423628 (rank : 6)	θ value	1.38499e-08 (rank : 12)
Query Neighborhood Hits	48	Target Neighborhood Hits	158	Shared Neighborhood Hits	13
SwissProt Accessions	P46062, P70204	Gene names	Sipa1, Spa-1, Spa1
Domain Architecture
Description	Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase- activating protein Spa-1).

SIPA1_HUMAN
NC score	0.421090 (rank : 7)	θ value	2.13673e-09 (rank : 7)
Query Neighborhood Hits	48	Target Neighborhood Hits	250	Shared Neighborhood Hits	16
SwissProt Accessions	Q96FS4, O14518, O60484, O60618	Gene names	SIPA1, SPA1
Domain Architecture
Description	Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase- activating protein Spa-1) (p130 SPA-1).

SI1L2_HUMAN
NC score	0.415448 (rank : 8)	θ value	3.64472e-09 (rank : 8)
Query Neighborhood Hits	48	Target Neighborhood Hits	131	Shared Neighborhood Hits	13
SwissProt Accessions	Q9P2F8, Q5VXR7, Q5VXR8, Q641Q4, Q8NA38, Q96DZ3, Q9H9F6	Gene names	SIPA1L2, KIAA1389
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

SI1L2_MOUSE
NC score	0.415387 (rank : 9)	θ value	3.64472e-09 (rank : 9)
Query Neighborhood Hits	48	Target Neighborhood Hits	124	Shared Neighborhood Hits	14
SwissProt Accessions	Q80TE4, Q6PDY1	Gene names	Sipa1l2, Kiaa0545
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 2.

SI1L3_HUMAN
NC score	0.411422 (rank : 10)	θ value	2.13673e-09 (rank : 6)
Query Neighborhood Hits	48	Target Neighborhood Hits	305	Shared Neighborhood Hits	15
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

SI1L1_HUMAN
NC score	0.410810 (rank : 11)	θ value	1.06045e-08 (rank : 10)
Query Neighborhood Hits	48	Target Neighborhood Hits	162	Shared Neighborhood Hits	13
SwissProt Accessions	O43166, O95321, Q9UDU4, Q9UNU4	Gene names	SIPA1L1, E6TP1, KIAA0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1 (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6- targeted protein 1).

SI1L1_MOUSE
NC score	0.409614 (rank : 12)	θ value	1.06045e-08 (rank : 11)
Query Neighborhood Hits	48	Target Neighborhood Hits	189	Shared Neighborhood Hits	13
SwissProt Accessions	Q8C0T5, Q6PDI8, Q80U02, Q8C026	Gene names	Sipa1l1, Kiaa0440
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 1.

FANCE_HUMAN
NC score	0.100384 (rank : 13)	θ value	0.813845 (rank : 17)
Query Neighborhood Hits	48	Target Neighborhood Hits	28	Shared Neighborhood Hits	3
SwissProt Accessions	Q9HB96, Q4ZGH2	Gene names	FANCE
Domain Architecture	No domain graphic available
Description	Fanconi anemia group E protein (Protein FACE).

VPS35_MOUSE
NC score	0.057976 (rank : 14)	θ value	0.365318 (rank : 15)
Query Neighborhood Hits	48	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	Q9EQH3, Q61123	Gene names	Vps35, Mem3
Domain Architecture
Description	Vacuolar protein sorting-associated protein 35 (Vesicle protein sorting 35) (Maternal-embryonic 3).

CJ067_HUMAN
NC score	0.055096 (rank : 15)	θ value	4.03905 (rank : 25)
Query Neighborhood Hits	48	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IYJ2, Q5SWD4	Gene names	C10orf67
Domain Architecture	No domain graphic available
Description	Protein C10orf67.

HD_MOUSE
NC score	0.054327 (rank : 16)	θ value	0.0330416 (rank : 13)
Query Neighborhood Hits	48	Target Neighborhood Hits	116	Shared Neighborhood Hits	2
SwissProt Accessions	P42859	Gene names	Hd, Hdh
Domain Architecture
Description	Huntingtin (Huntington disease protein homolog) (HD protein).

VPS35_HUMAN
NC score	0.052638 (rank : 17)	θ value	1.06291 (rank : 22)
Query Neighborhood Hits	48	Target Neighborhood Hits	24	Shared Neighborhood Hits	3
SwissProt Accessions	Q96QK1, Q561W2, Q9H016, Q9H096, Q9H4P3, Q9H8J0, Q9NRS7, Q9NVG2, Q9NX80, Q9NZK2	Gene names	VPS35, MEM3
Domain Architecture
Description	Vacuolar protein sorting-associated protein 35 (Vesicle protein sorting 35) (hVPS35) (Maternal-embryonic 3).

MAVS_HUMAN
NC score	0.042011 (rank : 18)	θ value	0.47712 (rank : 16)
Query Neighborhood Hits	48	Target Neighborhood Hits	271	Shared Neighborhood Hits	5
SwissProt Accessions	Q7Z434, Q3I0Y2, Q5T7I6, Q86VY7, Q9H1H3, Q9H4Y1, Q9H8D3, Q9ULE9	Gene names	MAVS, IPS1, KIAA1271, VISA
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif) (Putative NF-kappa-B- activating protein 031N).

ARI5B_HUMAN
NC score	0.040525 (rank : 19)	θ value	0.163984 (rank : 14)
Query Neighborhood Hits	48	Target Neighborhood Hits	328	Shared Neighborhood Hits	2
SwissProt Accessions	Q14865, Q7Z3M4, Q8N421, Q9H786	Gene names	ARID5B, DESRT, MRF2
Domain Architecture
Description	AT-rich interactive domain-containing protein 5B (ARID domain- containing protein 5B) (Mrf1-like) (Modulator recognition factor 2) (MRF-2).

PARM1_HUMAN
NC score	0.038665 (rank : 20)	θ value	1.38821 (rank : 23)
Query Neighborhood Hits	48	Target Neighborhood Hits	86	Shared Neighborhood Hits	2
SwissProt Accessions	Q6UWI2, Q96DV8, Q9Y4S1	Gene names	ames=UNQ1879/PRO4322
Domain Architecture	No domain graphic available
Description	Protein PARM-1 precursor.

PK1L1_HUMAN
NC score	0.034995 (rank : 21)	θ value	0.813845 (rank : 18)
Query Neighborhood Hits	48	Target Neighborhood Hits	140	Shared Neighborhood Hits	2
SwissProt Accessions	Q8TDX9, Q6UWK1	Gene names	PKD1L1
Domain Architecture
Description	Polycystic kidney disease 1-like 1 protein (Polycystin-1L1).

CTDP1_MOUSE
NC score	0.032565 (rank : 22)	θ value	8.99809 (rank : 39)
Query Neighborhood Hits	48	Target Neighborhood Hits	146	Shared Neighborhood Hits	4
SwissProt Accessions	Q7TSG2, Q7TSS7, Q9D4S8	Gene names	Ctdp1, Fcp1
Domain Architecture
Description	RNA polymerase II subunit A C-terminal domain phosphatase (EC 3.1.3.16) (TFIIF-associating CTD phosphatase).

TCF19_MOUSE
NC score	0.021508 (rank : 23)	θ value	5.27518 (rank : 30)
Query Neighborhood Hits	48	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	Q99KJ5, Q8BPA3, Q9CT93	Gene names	Tcf19, Sc1
Domain Architecture
Description	Transcription factor 19-like protein (SC1 protein homolog).

MAGI1_HUMAN
NC score	0.020712 (rank : 24)	θ value	1.06291 (rank : 19)
Query Neighborhood Hits	48	Target Neighborhood Hits	388	Shared Neighborhood Hits	10
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

TEX10_HUMAN
NC score	0.020587 (rank : 25)	θ value	6.88961 (rank : 37)
Query Neighborhood Hits	48	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	Q9NXF1, Q5T722, Q5T723, Q8NCN8, Q8TDY0	Gene names	TEX10
Domain Architecture	No domain graphic available
Description	Testis-expressed sequence 10 protein.

PRR6_MOUSE
NC score	0.019184 (rank : 26)	θ value	6.88961 (rank : 36)
Query Neighborhood Hits	48	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CXS4, Q5SX21, Q6PIA5	Gene names	Prr6
Domain Architecture	No domain graphic available
Description	Proline-rich protein 6.

STK23_MOUSE
NC score	0.018720 (rank : 27)	θ value	1.06291 (rank : 21)
Query Neighborhood Hits	48	Target Neighborhood Hits	572	Shared Neighborhood Hits	5
SwissProt Accessions	Q9Z0G2	Gene names	Stk23, Mssk1
Domain Architecture
Description	Serine/threonine-protein kinase 23 (EC 2.7.11.1) (Muscle-specific serine kinase 1) (MSSK-1).

NIBA_HUMAN
NC score	0.014344 (rank : 28)	θ value	6.88961 (rank : 34)
Query Neighborhood Hits	48	Target Neighborhood Hits	84	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BZQ8, Q5TEM8, Q8TEI5, Q9H593, Q9H9Y8, Q9HCB9	Gene names	C1orf24
Domain Architecture	No domain graphic available
Description	Niban protein.

TAF6_HUMAN
NC score	0.014260 (rank : 29)	θ value	8.99809 (rank : 48)
Query Neighborhood Hits	48	Target Neighborhood Hits	127	Shared Neighborhood Hits	6
SwissProt Accessions	P49848	Gene names	TAF6, TAF2E, TAFII70
Domain Architecture
Description	Transcription initiation factor TFIID subunit 6 (Transcription initiation factor TFIID 70 kDa subunit) (TAF(II)70) (TAFII-70) (TAFII- 80) (TAFII80).

GPR22_HUMAN
NC score	0.013107 (rank : 30)	θ value	4.03905 (rank : 27)
Query Neighborhood Hits	48	Target Neighborhood Hits	301	Shared Neighborhood Hits	2
SwissProt Accessions	Q99680, O14554	Gene names	GPR22
Domain Architecture
Description	Probable G-protein coupled receptor 22.

GR65_HUMAN
NC score	0.012548 (rank : 31)	θ value	6.88961 (rank : 31)
Query Neighborhood Hits	48	Target Neighborhood Hits	148	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BQQ3, Q8N272, Q96H42	Gene names	GORASP1, GRASP65
Domain Architecture	No domain graphic available
Description	Golgi reassembly-stacking protein 1 (Golgi reassembly-stacking protein of 65 kDa) (GRASP65) (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5).

DFNA5_MOUSE
NC score	0.011748 (rank : 32)	θ value	8.99809 (rank : 41)
Query Neighborhood Hits	48	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z2D3	Gene names	Dfna5, Dfna5h
Domain Architecture
Description	Non-syndromic hearing impairment protein 5 homolog.

MARCS_MOUSE
NC score	0.010764 (rank : 33)	θ value	8.99809 (rank : 46)
Query Neighborhood Hits	48	Target Neighborhood Hits	227	Shared Neighborhood Hits	3
SwissProt Accessions	P26645	Gene names	Marcks, Macs
Domain Architecture	No domain graphic available
Description	Myristoylated alanine-rich C-kinase substrate (MARCKS).

FOXH1_MOUSE
NC score	0.010118 (rank : 34)	θ value	4.03905 (rank : 26)
Query Neighborhood Hits	48	Target Neighborhood Hits	118	Shared Neighborhood Hits	3
SwissProt Accessions	O88621, Q9QZL5, Q9R241	Gene names	Foxh1, Fast1, Fast2
Domain Architecture
Description	Forkhead box protein H1 (Forkhead activin signal transducer 1) (Fast- 1) (Forkhead activin signal transducer 2) (Fast-2).

DYH5_HUMAN
NC score	0.009549 (rank : 35)	θ value	5.27518 (rank : 29)
Query Neighborhood Hits	48	Target Neighborhood Hits	323	Shared Neighborhood Hits	4
SwissProt Accessions	Q8TE73, Q92860, Q96L74, Q9H5S7, Q9HCG9	Gene names	DNAH5, DNAHC5, KIAA1603
Domain Architecture	No domain graphic available
Description	Ciliary dynein heavy chain 5 (Axonemal beta dynein heavy chain 5) (HL1).

PER3_HUMAN
NC score	0.008675 (rank : 36)	θ value	6.88961 (rank : 35)
Query Neighborhood Hits	48	Target Neighborhood Hits	479	Shared Neighborhood Hits	5
SwissProt Accessions	P56645, Q5H8X4, Q969K6, Q96S77, Q96S78, Q9C0J3, Q9NSP9, Q9UGU8	Gene names	PER3
Domain Architecture
Description	Period circadian protein 3 (hPER3).

HAIR_HUMAN
NC score	0.008334 (rank : 37)	θ value	8.99809 (rank : 44)
Query Neighborhood Hits	48	Target Neighborhood Hits	172	Shared Neighborhood Hits	2
SwissProt Accessions	O43593, Q96H33, Q9NPE1	Gene names	HR
Domain Architecture
Description	Protein hairless.

SRBP1_MOUSE
NC score	0.007972 (rank : 38)	θ value	8.99809 (rank : 47)
Query Neighborhood Hits	48	Target Neighborhood Hits	384	Shared Neighborhood Hits	2
SwissProt Accessions	Q9WTN3	Gene names	Srebf1, Srebp1
Domain Architecture
Description	Sterol regulatory element-binding protein 1 (SREBP-1) (Sterol regulatory element-binding transcription factor 1).

MAST2_MOUSE
NC score	0.007015 (rank : 39)	θ value	1.06291 (rank : 20)
Query Neighborhood Hits	48	Target Neighborhood Hits	1110	Shared Neighborhood Hits	11
SwissProt Accessions	Q60592, Q6P9M1, Q8CHD1	Gene names	Mast2, Mast205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

KLC1_HUMAN
NC score	0.006734 (rank : 40)	θ value	6.88961 (rank : 33)
Query Neighborhood Hits	48	Target Neighborhood Hits	471	Shared Neighborhood Hits	4
SwissProt Accessions	Q07866, Q7RTM2, Q7RTM3, Q7RTM5, Q7RTP9, Q7RTQ5, Q86SF5, Q86TF5, Q86V74, Q86V75, Q86V76, Q86V77, Q86V78, Q86V79, Q96H62	Gene names	KNS2, KLC, KLC1
Domain Architecture
Description	Kinesin light chain 1 (KLC 1).

LUZP1_MOUSE
NC score	0.006521 (rank : 41)	θ value	8.99809 (rank : 45)
Query Neighborhood Hits	48	Target Neighborhood Hits	940	Shared Neighborhood Hits	5
SwissProt Accessions	Q8R4U7, Q3UV18, Q7TS71, Q8BQW1, Q99NG3, Q9CSL6	Gene names	Luzp1, Luzp
Domain Architecture	No domain graphic available
Description	Leucine zipper protein 1 (Leucine zipper motif-containing protein).

MAST2_HUMAN
NC score	0.006359 (rank : 42)	θ value	3.0926 (rank : 24)
Query Neighborhood Hits	48	Target Neighborhood Hits	1189	Shared Neighborhood Hits	11
SwissProt Accessions	Q6P0Q8, O94899, Q5VT07, Q5VT08, Q7LGC4, Q8NDG1, Q96B94, Q9BYE8	Gene names	MAST2, KIAA0807, MAST205
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 2 (EC 2.7.11.1).

ELF1_MOUSE
NC score	0.005867 (rank : 43)	θ value	8.99809 (rank : 42)
Query Neighborhood Hits	48	Target Neighborhood Hits	139	Shared Neighborhood Hits	3
SwissProt Accessions	Q60775	Gene names	Elf1
Domain Architecture
Description	ETS-related transcription factor Elf-1 (E74-like factor 1).

FOXI1_HUMAN
NC score	0.004833 (rank : 44)	θ value	8.99809 (rank : 43)
Query Neighborhood Hits	48	Target Neighborhood Hits	104	Shared Neighborhood Hits	3
SwissProt Accessions	Q12951, Q14518, Q66SR7, Q8N6L8	Gene names	FOXI1, FKHL10, FREAC6
Domain Architecture
Description	Forkhead box protein I1 (Forkhead-related protein FKHL10) (Forkhead- related transcription factor 6) (FREAC-6) (Hepatocyte nuclear factor 3 forkhead homolog 3) (HNF-3/fork-head homolog 3) (HFH-3).

CAN11_HUMAN
NC score	0.004526 (rank : 45)	θ value	8.99809 (rank : 38)
Query Neighborhood Hits	48	Target Neighborhood Hits	63	Shared Neighborhood Hits	2
SwissProt Accessions	Q9UMQ6, Q8N4R5	Gene names	CAPN11
Domain Architecture
Description	Calpain-11 (EC 3.4.22.-) (Calcium-activated neutral proteinase 11) (CANP 11).

IASPP_MOUSE
NC score	0.004294 (rank : 46)	θ value	6.88961 (rank : 32)
Query Neighborhood Hits	48	Target Neighborhood Hits	1024	Shared Neighborhood Hits	2
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

CNTN6_MOUSE
NC score	0.003134 (rank : 47)	θ value	5.27518 (rank : 28)
Query Neighborhood Hits	48	Target Neighborhood Hits	429	Shared Neighborhood Hits	2
SwissProt Accessions	Q9JMB8, Q8C6X1	Gene names	Cntn6
Domain Architecture	No domain graphic available
Description	Contactin-6 precursor (Neural recognition molecule NB-3) (mNB-3).

CTRO_MOUSE
NC score	0.000087 (rank : 48)	θ value	8.99809 (rank : 40)
Query Neighborhood Hits	48	Target Neighborhood Hits	2344	Shared Neighborhood Hits	10
SwissProt Accessions	P49025, O88528, O88937, O88938, Q3UM99, Q8CIJ1	Gene names	Cit
Domain Architecture
Description	Citron Rho-interacting kinase (EC 2.7.11.1) (CRIK) (Rho-interacting, serine/threonine-protein kinase 21).