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Network neighborhood for query Sequence : WWOX_MOUSE

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WWOX_MOUSE
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

WWOX_HUMAN
θ value	0 (rank : 1)	NC score	0.996602 (rank : 2)
Query Neighborhood Hits	118	Target Neighborhood Hits	115	Shared Neighborhood Hits	113
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

WWOX_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	118	Target Neighborhood Hits	118	Shared Neighborhood Hits	118
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

RDH12_MOUSE
θ value	9.45883e-58 (rank : 3)	NC score	0.815223 (rank : 5)
Query Neighborhood Hits	118	Target Neighborhood Hits	74	Shared Neighborhood Hits	64
SwissProt Accessions	Q8BYK4, Q91WA5, Q9D1Y4	Gene names	Rdh12
Domain Architecture
Description	Retinol dehydrogenase 12 (EC 1.1.1.-).

RDH12_HUMAN
θ value	1.41344e-53 (rank : 4)	NC score	0.812596 (rank : 6)
Query Neighborhood Hits	118	Target Neighborhood Hits	72	Shared Neighborhood Hits	64
SwissProt Accessions	Q96NR8, Q8TAW6	Gene names	RDH12
Domain Architecture
Description	Retinol dehydrogenase 12 (EC 1.1.1.-) (All-trans and 9-cis retinol dehydrogenase).

RDH11_MOUSE
θ value	2.75849e-49 (rank : 5)	NC score	0.805910 (rank : 7)
Query Neighborhood Hits	118	Target Neighborhood Hits	69	Shared Neighborhood Hits	65
SwissProt Accessions	Q9QYF1, Q3UXM9, Q9D0U5	Gene names	Rdh11, Arsdr1, Mdt1, Psdr1
Domain Architecture
Description	Retinol dehydrogenase 11 (EC 1.1.1.-) (Retinal reductase 1) (RalR1) (Prostate short-chain dehydrogenase/reductase 1) (Androgen-regulated short-chain dehydrogenase/reductase 1) (Short-chain aldehyde dehydrogenase) (SCALD) (Cell line MC/9.IL4-derived protein 1) (M42C60).

RDH11_HUMAN
θ value	3.60269e-49 (rank : 6)	NC score	0.803034 (rank : 10)
Query Neighborhood Hits	118	Target Neighborhood Hits	71	Shared Neighborhood Hits	65
SwissProt Accessions	Q8TC12, Q9NRW0, Q9Y391	Gene names	RDH11, ARSDR1, PSDR1
Domain Architecture
Description	Retinol dehydrogenase 11 (EC 1.1.1.-) (Retinal reductase 1) (RalR1) (Prostate short-chain dehydrogenase/reductase 1) (Androgen-regulated short-chain dehydrogenase/reductase 1) (HCV core-binding protein HCBP12).

RDH14_HUMAN
θ value	1.15895e-47 (rank : 7)	NC score	0.819358 (rank : 3)
Query Neighborhood Hits	118	Target Neighborhood Hits	76	Shared Neighborhood Hits	65
SwissProt Accessions	Q9HBH5	Gene names	RDH14, PAN2
Domain Architecture
Description	Retinol dehydrogenase 14 (EC 1.1.1.-) (Alcohol dehydrogenase PAN2).

RDH14_MOUSE
θ value	5.7518e-47 (rank : 8)	NC score	0.816044 (rank : 4)
Query Neighborhood Hits	118	Target Neighborhood Hits	74	Shared Neighborhood Hits	64
SwissProt Accessions	Q9ERI6	Gene names	Rdh14
Domain Architecture
Description	Retinol dehydrogenase 14 (EC 1.1.1.-) (Alcohol dehydrogenase PAN2).

RDH13_HUMAN
θ value	8.30557e-46 (rank : 9)	NC score	0.803474 (rank : 9)
Query Neighborhood Hits	118	Target Neighborhood Hits	74	Shared Neighborhood Hits	66
SwissProt Accessions	Q8NBN7, Q6UX79, Q96G88	Gene names	RDH13
Domain Architecture
Description	Retinol dehydrogenase 13 (EC 1.1.1.-).

RDH13_MOUSE
θ value	1.41672e-45 (rank : 10)	NC score	0.799093 (rank : 11)
Query Neighborhood Hits	118	Target Neighborhood Hits	75	Shared Neighborhood Hits	66
SwissProt Accessions	Q8CEE7, Q8CC07	Gene names	Rdh13
Domain Architecture
Description	Retinol dehydrogenase 13 (EC 1.1.1.-).

DHRSX_HUMAN
θ value	6.15952e-41 (rank : 11)	NC score	0.803492 (rank : 8)
Query Neighborhood Hits	118	Target Neighborhood Hits	71	Shared Neighborhood Hits	61
SwissProt Accessions	Q8N5I4, Q6UWC7, Q8WUS4, Q96GR8, Q9NTF6	Gene names	DHRSX, CXorf11, DHRS5X
Domain Architecture
Description	Dehydrogenase/reductase SDR family member on chromosome X precursor (EC 1.1.-.-) (DHRSXY).

DHB7_HUMAN
θ value	6.20254e-17 (rank : 12)	NC score	0.627110 (rank : 12)
Query Neighborhood Hits	118	Target Neighborhood Hits	49	Shared Neighborhood Hits	42
SwissProt Accessions	P56937, Q7Z4V9, Q8WWS2, Q9UF00	Gene names	HSD17B7
Domain Architecture
Description	3-keto-steroid reductase (EC 1.1.1.270) (Estradiol 17-beta- dehydrogenase 7) (EC 1.1.1.62) (17-beta-HSD 7) (17-beta-hydroxysteroid dehydrogenase 7).

DHB7_MOUSE
θ value	6.85773e-16 (rank : 13)	NC score	0.614877 (rank : 13)
Query Neighborhood Hits	118	Target Neighborhood Hits	42	Shared Neighborhood Hits	37
SwissProt Accessions	O88736, Q8K5C9, Q921L1	Gene names	Hsd17b7
Domain Architecture
Description	3-keto-steroid reductase (EC 1.1.1.270) (Estradiol 17-beta- dehydrogenase 7) (EC 1.1.1.62) (17-beta-HSD 7) (17-beta-hydroxysteroid dehydrogenase 7).

ITCH_HUMAN
θ value	6.41864e-14 (rank : 14)	NC score	0.390983 (rank : 52)
Query Neighborhood Hits	118	Target Neighborhood Hits	162	Shared Neighborhood Hits	47
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

ITCH_MOUSE
θ value	6.41864e-14 (rank : 15)	NC score	0.393406 (rank : 49)
Query Neighborhood Hits	118	Target Neighborhood Hits	127	Shared Neighborhood Hits	47
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

WWP2_HUMAN
θ value	4.16044e-13 (rank : 16)	NC score	0.394927 (rank : 46)
Query Neighborhood Hits	118	Target Neighborhood Hits	177	Shared Neighborhood Hits	49
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP2_MOUSE
θ value	4.16044e-13 (rank : 17)	NC score	0.395927 (rank : 45)
Query Neighborhood Hits	118	Target Neighborhood Hits	118	Shared Neighborhood Hits	49
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

NED4L_HUMAN
θ value	1.02475e-11 (rank : 18)	NC score	0.354433 (rank : 69)
Query Neighborhood Hits	118	Target Neighborhood Hits	238	Shared Neighborhood Hits	49
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NEDD4_MOUSE
θ value	1.02475e-11 (rank : 19)	NC score	0.359517 (rank : 66)
Query Neighborhood Hits	118	Target Neighborhood Hits	212	Shared Neighborhood Hits	49
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

WWP1_HUMAN
θ value	1.02475e-11 (rank : 20)	NC score	0.389404 (rank : 53)
Query Neighborhood Hits	118	Target Neighborhood Hits	262	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

WWP1_MOUSE
θ value	1.74796e-11 (rank : 21)	NC score	0.393572 (rank : 48)
Query Neighborhood Hits	118	Target Neighborhood Hits	138	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

YAP1_MOUSE
θ value	1.74796e-11 (rank : 22)	NC score	0.454873 (rank : 21)
Query Neighborhood Hits	118	Target Neighborhood Hits	96	Shared Neighborhood Hits	48
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

MAGI2_HUMAN
θ value	3.89403e-11 (rank : 23)	NC score	0.290156 (rank : 94)
Query Neighborhood Hits	118	Target Neighborhood Hits	373	Shared Neighborhood Hits	39
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

NED4L_MOUSE
θ value	3.89403e-11 (rank : 24)	NC score	0.353948 (rank : 70)
Query Neighborhood Hits	118	Target Neighborhood Hits	231	Shared Neighborhood Hits	49
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

MAGI2_MOUSE
θ value	8.67504e-11 (rank : 25)	NC score	0.295190 (rank : 92)
Query Neighborhood Hits	118	Target Neighborhood Hits	370	Shared Neighborhood Hits	43
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

NEDD4_HUMAN
θ value	2.52405e-10 (rank : 26)	NC score	0.356658 (rank : 68)
Query Neighborhood Hits	118	Target Neighborhood Hits	214	Shared Neighborhood Hits	48
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

SMUF2_HUMAN
θ value	9.59137e-10 (rank : 27)	NC score	0.367161 (rank : 62)
Query Neighborhood Hits	118	Target Neighborhood Hits	142	Shared Neighborhood Hits	45
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SMUF1_MOUSE
θ value	1.25267e-09 (rank : 28)	NC score	0.360687 (rank : 65)
Query Neighborhood Hits	118	Target Neighborhood Hits	142	Shared Neighborhood Hits	40
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

WWC1_HUMAN
θ value	1.25267e-09 (rank : 29)	NC score	0.373264 (rank : 58)
Query Neighborhood Hits	118	Target Neighborhood Hits	290	Shared Neighborhood Hits	41
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
θ value	6.21693e-09 (rank : 30)	NC score	0.368829 (rank : 61)
Query Neighborhood Hits	118	Target Neighborhood Hits	290	Shared Neighborhood Hits	37
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

SAV1_HUMAN
θ value	2.36244e-08 (rank : 31)	NC score	0.446930 (rank : 25)
Query Neighborhood Hits	118	Target Neighborhood Hits	51	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SAV1_MOUSE
θ value	3.08544e-08 (rank : 32)	NC score	0.445957 (rank : 26)
Query Neighborhood Hits	118	Target Neighborhood Hits	48	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

DHRS8_HUMAN
θ value	1.17247e-07 (rank : 33)	NC score	0.486711 (rank : 15)
Query Neighborhood Hits	118	Target Neighborhood Hits	68	Shared Neighborhood Hits	64
SwissProt Accessions	Q8NBQ5, Q96HF6, Q9UKU4	Gene names	DHRS8, HSD17B11, PAN1B
Domain Architecture	No domain graphic available
Description	Dehydrogenase/reductase SDR family member 8 precursor (EC 1.1.1.-) (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17-beta- HSD XI) (17betaHSDXI) (17bHSD11) (17betaHSD11) (Retinal short-chain dehydrogenase/reductase 2) (retSDR2) (Cutaneous T-cell lymphoma- associated antigen HD-CL-03) (CTCL tumor antigen HD-CL-03).

MAGI1_MOUSE
θ value	2.61198e-07 (rank : 34)	NC score	0.265702 (rank : 98)
Query Neighborhood Hits	118	Target Neighborhood Hits	403	Shared Neighborhood Hits	46
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MAGI1_HUMAN
θ value	3.41135e-07 (rank : 35)	NC score	0.266241 (rank : 97)
Query Neighborhood Hits	118	Target Neighborhood Hits	388	Shared Neighborhood Hits	45
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

DHB13_MOUSE
θ value	5.81887e-07 (rank : 36)	NC score	0.462401 (rank : 20)
Query Neighborhood Hits	118	Target Neighborhood Hits	69	Shared Neighborhood Hits	63
SwissProt Accessions	Q8VCR2, Q8CIU2	Gene names	Hsd17b13, Scdr9
Domain Architecture	No domain graphic available
Description	17-beta hydroxysteroid dehydrogenase 13 precursor (EC 1.1.-.-) (Short- chain dehydrogenase/reductase 9) (Alcohol dehydrogenase PAN1B-like).

DECR2_HUMAN
θ value	9.92553e-07 (rank : 37)	NC score	0.391259 (rank : 51)
Query Neighborhood Hits	118	Target Neighborhood Hits	65	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NUI1, Q6ZRS7, Q96ET0	Gene names	DECR2, PDCR
Domain Architecture	No domain graphic available
Description	Peroxisomal 2,4-dienoyl-CoA reductase (EC 1.3.1.34) (2,4-dienoyl-CoA reductase 2) (pDCR).

PKHA5_HUMAN
θ value	1.29631e-06 (rank : 38)	NC score	0.233243 (rank : 100)
Query Neighborhood Hits	118	Target Neighborhood Hits	455	Shared Neighborhood Hits	36
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

SMUF1_HUMAN
θ value	1.29631e-06 (rank : 39)	NC score	0.346824 (rank : 74)
Query Neighborhood Hits	118	Target Neighborhood Hits	135	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

DECR2_MOUSE
θ value	1.69304e-06 (rank : 40)	NC score	0.359484 (rank : 67)
Query Neighborhood Hits	118	Target Neighborhood Hits	63	Shared Neighborhood Hits	56
SwissProt Accessions	Q9WV68	Gene names	Decr2, Pdcr
Domain Architecture	No domain graphic available
Description	Peroxisomal 2,4-dienoyl-CoA reductase (EC 1.3.1.34) (2,4-dienoyl-CoA reductase 2).

DHRS8_MOUSE
θ value	1.69304e-06 (rank : 41)	NC score	0.471742 (rank : 18)
Query Neighborhood Hits	118	Target Neighborhood Hits	72	Shared Neighborhood Hits	64
SwissProt Accessions	Q9EQ06, Q3U2P6, Q8BR33, Q8C7S0	Gene names	Dhrs8, Hsd17b11, Pan1b
Domain Architecture	No domain graphic available
Description	Dehydrogenase/reductase SDR family member 8 precursor (EC 1.1.1.-) (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17-beta- HSD XI) (17betaHSDXI) (17bHSD11) (17betaHSD11).

DHRS4_HUMAN
θ value	4.92598e-06 (rank : 42)	NC score	0.386661 (rank : 55)
Query Neighborhood Hits	118	Target Neighborhood Hits	70	Shared Neighborhood Hits	63
SwissProt Accessions	Q9BTZ2, O95162, Q6UWU3, Q8TD03, Q9H3N5, Q9NV08	Gene names	DHRS4
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (NADPH- dependent carbonyl reductase/NADP-retinol dehydrogenase) (CR) (PHCR) (Peroxisomal short-chain alcohol dehydrogenase) (NADPH-dependent retinol dehydrogenase/reductase) (NDRD) (SCAD-SRL) (humNRDR) (PSCD).

DHB13_HUMAN
θ value	1.43324e-05 (rank : 43)	NC score	0.449897 (rank : 23)
Query Neighborhood Hits	118	Target Neighborhood Hits	70	Shared Neighborhood Hits	61
SwissProt Accessions	Q7Z5P4, Q86W22, Q86W23	Gene names	HSD17B13, SCDR9
Domain Architecture	No domain graphic available
Description	17-beta hydroxysteroid dehydrogenase 13 precursor (EC 1.1.-.-) (Short- chain dehydrogenase/reductase 9).

YAP1_HUMAN
θ value	4.1701e-05 (rank : 44)	NC score	0.342441 (rank : 78)
Query Neighborhood Hits	118	Target Neighborhood Hits	173	Shared Neighborhood Hits	46
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

DHRS9_HUMAN
θ value	7.1131e-05 (rank : 45)	NC score	0.418548 (rank : 34)
Query Neighborhood Hits	118	Target Neighborhood Hits	65	Shared Neighborhood Hits	60
SwissProt Accessions	Q9BPW9, Q5RKX1, Q9NRA9, Q9NRB0	Gene names	DHRS9
Domain Architecture	No domain graphic available
Description	Dehydrogenase/reductase SDR family member 9 precursor (EC 1.1.-.-) (3- alpha hydroxysteroid dehydrogenase) (3alpha-HSD) (RDH-E2) (Short-chain dehydrogenase/reductase retSDR8) (NADP-dependent retinol dehydrogenase/reductase) (RDHL).

RDH1_HUMAN
θ value	7.1131e-05 (rank : 46)	NC score	0.420050 (rank : 33)
Query Neighborhood Hits	118	Target Neighborhood Hits	68	Shared Neighborhood Hits	59
SwissProt Accessions	Q92781, Q8TAI2	Gene names	RDH5, RDH1
Domain Architecture
Description	11-cis retinol dehydrogenase (EC 1.1.1.105) (11-cis RDH).

PIN1_MOUSE
θ value	0.000121331 (rank : 47)	NC score	0.320490 (rank : 87)
Query Neighborhood Hits	118	Target Neighborhood Hits	60	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

DHRS7_HUMAN
θ value	0.00020696 (rank : 48)	NC score	0.478664 (rank : 17)
Query Neighborhood Hits	118	Target Neighborhood Hits	73	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Y394, Q9UKU2	Gene names	DHRS7, RETSDR4
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 7 precursor (EC 1.1.-.-) (Retinal short-chain dehydrogenase/reductase 4) (retSDR4).

PECR_MOUSE
θ value	0.00020696 (rank : 49)	NC score	0.421405 (rank : 32)
Query Neighborhood Hits	118	Target Neighborhood Hits	73	Shared Neighborhood Hits	66
SwissProt Accessions	Q99MZ7, Q9CX01, Q9JIF4	Gene names	Pecr
Domain Architecture	No domain graphic available
Description	Peroxisomal trans-2-enoyl-CoA reductase (EC 1.3.1.38).

BDH_MOUSE
θ value	0.000270298 (rank : 50)	NC score	0.378543 (rank : 57)
Query Neighborhood Hits	118	Target Neighborhood Hits	70	Shared Neighborhood Hits	62
SwissProt Accessions	Q80XN0, Q3UJS9, Q8BK53, Q8R0C8	Gene names	Bdh1, Bdh
Domain Architecture	No domain graphic available
Description	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor (EC 1.1.1.30) (BDH) (3-hydroxybutyrate dehydrogenase).

BDH_HUMAN
θ value	0.00035302 (rank : 51)	NC score	0.332292 (rank : 82)
Query Neighborhood Hits	118	Target Neighborhood Hits	65	Shared Neighborhood Hits	60
SwissProt Accessions	Q02338, Q96ET1, Q9BRZ4	Gene names	BDH1, BDH
Domain Architecture
Description	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor (EC 1.1.1.30) (BDH) (3-hydroxybutyrate dehydrogenase).

PIN1_HUMAN
θ value	0.00035302 (rank : 52)	NC score	0.314322 (rank : 89)
Query Neighborhood Hits	118	Target Neighborhood Hits	59	Shared Neighborhood Hits	40
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

DHRS7_MOUSE
θ value	0.000461057 (rank : 53)	NC score	0.489211 (rank : 14)
Query Neighborhood Hits	118	Target Neighborhood Hits	75	Shared Neighborhood Hits	66
SwissProt Accessions	Q9CXR1	Gene names	Dhrs7, Retsdr4
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 7 precursor (EC 1.1.-.-) (Retinal short-chain dehydrogenase/reductase 4).

DHI1_MOUSE
θ value	0.000602161 (rank : 54)	NC score	0.403469 (rank : 41)
Query Neighborhood Hits	118	Target Neighborhood Hits	78	Shared Neighborhood Hits	63
SwissProt Accessions	P50172	Gene names	Hsd11b1, Hsd11
Domain Architecture
Description	Corticosteroid 11-beta-dehydrogenase isozyme 1 (EC 1.1.1.146) (11-DH) (11-beta-hydroxysteroid dehydrogenase 1) (11-beta-HSD1) (11beta- HSD1A).

DHRS2_HUMAN
θ value	0.000602161 (rank : 55)	NC score	0.391439 (rank : 50)
Query Neighborhood Hits	118	Target Neighborhood Hits	72	Shared Neighborhood Hits	65
SwissProt Accessions	Q13268, Q9H2R2	Gene names	DHRS2
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 2 (EC 1.1.-.-) (HEP27 protein) (Protein D).

PGDH_MOUSE
θ value	0.000602161 (rank : 56)	NC score	0.448661 (rank : 24)
Query Neighborhood Hits	118	Target Neighborhood Hits	73	Shared Neighborhood Hits	63
SwissProt Accessions	Q8VCC1, Q61106	Gene names	Hpgd, Pgdh1
Domain Architecture	No domain graphic available
Description	15-hydroxyprostaglandin dehydrogenase [NAD+] (EC 1.1.1.141) (PGDH) (Prostaglandin dehydrogenase 1).

RDH7_MOUSE
θ value	0.000786445 (rank : 57)	NC score	0.422558 (rank : 31)
Query Neighborhood Hits	118	Target Neighborhood Hits	72	Shared Neighborhood Hits	65
SwissProt Accessions	O88451	Gene names	Rdh7, Crad2
Domain Architecture	No domain graphic available
Description	Retinol dehydrogenase 7 (EC 1.1.1.105) (Cis-retinol/androgen dehydrogenase type 2) (CRAD-2) (cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase isozyme 2).

DHB4_HUMAN
θ value	0.00102713 (rank : 58)	NC score	0.291727 (rank : 93)
Query Neighborhood Hits	118	Target Neighborhood Hits	83	Shared Neighborhood Hits	59
SwissProt Accessions	P51659	Gene names	HSD17B4, EDH17B4
Domain Architecture
Description	Peroxisomal multifunctional enzyme type 2 (MFE-2) (D-bifunctional protein) (DBP) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-3-hydroxyacyl-CoA dehydratase) (EC 4.2.1.107) (3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase) (3- hydroxyacyl-CoA dehydrogenase) (EC 1.1.1.35).

DHCA_HUMAN
θ value	0.00102713 (rank : 59)	NC score	0.467951 (rank : 19)
Query Neighborhood Hits	118	Target Neighborhood Hits	63	Shared Neighborhood Hits	58
SwissProt Accessions	P16152	Gene names	CBR1, CBR, CRN
Domain Architecture
Description	Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 1) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) (Prostaglandin 9-ketoreductase) (15-hydroxyprostaglandin dehydrogenase [NADP+]) (EC 1.1.1.197).

WWTR1_HUMAN
θ value	0.00102713 (rank : 60)	NC score	0.330612 (rank : 84)
Query Neighborhood Hits	118	Target Neighborhood Hits	76	Shared Neighborhood Hits	38
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

WWTR1_MOUSE
θ value	0.00102713 (rank : 61)	NC score	0.334222 (rank : 81)
Query Neighborhood Hits	118	Target Neighborhood Hits	54	Shared Neighborhood Hits	39
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

DHI1_HUMAN
θ value	0.00134147 (rank : 62)	NC score	0.428506 (rank : 28)
Query Neighborhood Hits	118	Target Neighborhood Hits	72	Shared Neighborhood Hits	63
SwissProt Accessions	P28845	Gene names	HSD11B1, HSD11, HSD11L
Domain Architecture
Description	Corticosteroid 11-beta-dehydrogenase isozyme 1 (EC 1.1.1.146) (11-DH) (11-beta-hydroxysteroid dehydrogenase 1) (11-beta-HSD1).

DHRS4_MOUSE
θ value	0.00134147 (rank : 63)	NC score	0.364518 (rank : 63)
Query Neighborhood Hits	118	Target Neighborhood Hits	67	Shared Neighborhood Hits	60
SwissProt Accessions	Q99LB2, Q9EQU4	Gene names	Dhrs4, D14Ucla2
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (NADPH- dependent carbonyl reductase/NADP-retinol dehydrogenase) (CR) (PHCR) (Peroxisomal short-chain alcohol dehydrogenase) (NADPH-dependent retinol dehydrogenase/reductase) (NDRD) (mouNRDR).

CBR2_MOUSE
θ value	0.00175202 (rank : 64)	NC score	0.414492 (rank : 36)
Query Neighborhood Hits	118	Target Neighborhood Hits	75	Shared Neighborhood Hits	63
SwissProt Accessions	P08074	Gene names	Cbr2
Domain Architecture
Description	Lung carbonyl reductase [NADPH] (EC 1.1.1.184) (NADPH-dependent carbonyl reductase) (LCR) (Adipocyte P27 protein) (AP27).

DCXR_MOUSE
θ value	0.00228821 (rank : 65)	NC score	0.387710 (rank : 54)
Query Neighborhood Hits	118	Target Neighborhood Hits	71	Shared Neighborhood Hits	62
SwissProt Accessions	Q91X52, Q3U5L5, Q9D129, Q9D8W1	Gene names	Dcxr
Domain Architecture	No domain graphic available
Description	L-xylulose reductase (EC 1.1.1.10) (XR) (Dicarbonyl/L-xylulose reductase).

DHC3_HUMAN
θ value	0.00228821 (rank : 66)	NC score	0.480097 (rank : 16)
Query Neighborhood Hits	118	Target Neighborhood Hits	67	Shared Neighborhood Hits	60
SwissProt Accessions	O75828	Gene names	CBR3
Domain Architecture
Description	Carbonyl reductase [NADPH] 3 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 3).

PINL_HUMAN
θ value	0.00228821 (rank : 67)	NC score	0.345149 (rank : 76)
Query Neighborhood Hits	118	Target Neighborhood Hits	47	Shared Neighborhood Hits	39
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

STXB4_HUMAN
θ value	0.00228821 (rank : 68)	NC score	0.165474 (rank : 119)
Query Neighborhood Hits	118	Target Neighborhood Hits	616	Shared Neighborhood Hits	42
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_MOUSE
θ value	0.00228821 (rank : 69)	NC score	0.167115 (rank : 118)
Query Neighborhood Hits	118	Target Neighborhood Hits	629	Shared Neighborhood Hits	42
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

DHI2_MOUSE
θ value	0.00298849 (rank : 70)	NC score	0.345628 (rank : 75)
Query Neighborhood Hits	118	Target Neighborhood Hits	65	Shared Neighborhood Hits	58
SwissProt Accessions	P51661, Q91WK3	Gene names	Hsd11b2, Hsd11k
Domain Architecture
Description	Corticosteroid 11-beta-dehydrogenase isozyme 2 (EC 1.1.1.-) (11-DH2) (11-beta-hydroxysteroid dehydrogenase type 2) (11-beta-HSD2) (NAD- dependent 11-beta-hydroxysteroid dehydrogenase).

DHRS9_MOUSE
θ value	0.00509761 (rank : 71)	NC score	0.415330 (rank : 35)
Query Neighborhood Hits	118	Target Neighborhood Hits	70	Shared Neighborhood Hits	62
SwissProt Accessions	Q58NB6, Q8BGC7	Gene names	Dhrs9
Domain Architecture	No domain graphic available
Description	Dehydrogenase/reductase SDR family member 9 precursor (EC 1.1.-.-) (3- alpha hydroxysteroid dehydrogenase) (3alpha-HSD) (Short-chain dehydrogenase/reductase retSDR8).

DHCA_MOUSE
θ value	0.00665767 (rank : 72)	NC score	0.452140 (rank : 22)
Query Neighborhood Hits	118	Target Neighborhood Hits	61	Shared Neighborhood Hits	55
SwissProt Accessions	P48758	Gene names	Cbr1, Cbr
Domain Architecture
Description	Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 1).

DHR10_HUMAN
θ value	0.00665767 (rank : 73)	NC score	0.407870 (rank : 38)
Query Neighborhood Hits	118	Target Neighborhood Hits	71	Shared Neighborhood Hits	64
SwissProt Accessions	Q9BPX1, Q9UKU3	Gene names	DHRS10, SDR3
Domain Architecture	No domain graphic available
Description	Dehydrogenase/reductase SDR family member 10 (EC 1.1.-.-) (Retinal short-chain dehydrogenase/reductase retSDR3).

PGDH_HUMAN
θ value	0.00665767 (rank : 74)	NC score	0.429789 (rank : 27)
Query Neighborhood Hits	118	Target Neighborhood Hits	73	Shared Neighborhood Hits	62
SwissProt Accessions	P15428	Gene names	HPGD, PGDH1
Domain Architecture
Description	15-hydroxyprostaglandin dehydrogenase [NAD+] (EC 1.1.1.141) (PGDH) (Prostaglandin dehydrogenase 1).

DHB12_HUMAN
θ value	0.00869519 (rank : 75)	NC score	0.371164 (rank : 60)
Query Neighborhood Hits	118	Target Neighborhood Hits	69	Shared Neighborhood Hits	62
SwissProt Accessions	Q53GQ0, Q96JU2, Q9Y6G8	Gene names	HSD17B12
Domain Architecture	No domain graphic available
Description	Estradiol 17-beta-dehydrogenase 12 (EC 1.1.1.62) (17-beta-HSD 12) (17- beta-hydroxysteroid dehydrogenase 12) (3-ketoacyl-CoA reductase) (EC 1.3.1.-) (KAR).

DHB4_MOUSE
θ value	0.0148317 (rank : 76)	NC score	0.278420 (rank : 95)
Query Neighborhood Hits	118	Target Neighborhood Hits	78	Shared Neighborhood Hits	59
SwissProt Accessions	P51660, Q9DBM3	Gene names	Hsd17b4, Edh17b4
Domain Architecture
Description	Peroxisomal multifunctional enzyme type 2 (MFE-2) (D-bifunctional protein) (DBP) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-3-hydroxyacyl-CoA dehydratase) (EC 4.2.1.107) (3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase) (3- hydroxyacyl-CoA dehydrogenase) (EC 1.1.1.35).

DHRS3_MOUSE
θ value	0.0193708 (rank : 77)	NC score	0.399633 (rank : 43)
Query Neighborhood Hits	118	Target Neighborhood Hits	74	Shared Neighborhood Hits	64
SwissProt Accessions	O88876, Q3UAD1, Q91WR0, Q91XC3, Q922A6	Gene names	Dhrs3, Rsdr1
Domain Architecture
Description	Short-chain dehydrogenase/reductase 3 (EC 1.1.-.-) (Retinal short- chain dehydrogenase/reductase 1) (retSDR1).

BDH2_MOUSE
θ value	0.0252991 (rank : 78)	NC score	0.406339 (rank : 39)
Query Neighborhood Hits	118	Target Neighborhood Hits	70	Shared Neighborhood Hits	60
SwissProt Accessions	Q8JZV9	Gene names	Bdh2, Dhrs6
Domain Architecture	No domain graphic available
Description	3-hydroxybutyrate dehydrogenase type 2 (EC 1.1.1.30) (R-beta- hydroxybutyrate dehydrogenase) (Dehydrogenase/reductase SDR family member 6).

DHB1_HUMAN
θ value	0.0252991 (rank : 79)	NC score	0.351905 (rank : 71)
Query Neighborhood Hits	118	Target Neighborhood Hits	67	Shared Neighborhood Hits	63
SwissProt Accessions	P14061	Gene names	HSD17B1, E17KSR, EDH17B1, EDHB17
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 1 (EC 1.1.1.62) (17-beta- hydroxysteroid dehydrogenase type 1) (17-beta-HSD 1) (Placental 17- beta-hydroxysteroid dehydrogenase) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH).

DHI2_HUMAN
θ value	0.0330416 (rank : 80)	NC score	0.276850 (rank : 96)
Query Neighborhood Hits	118	Target Neighborhood Hits	62	Shared Neighborhood Hits	57
SwissProt Accessions	P80365, Q13194, Q8N439, Q96QN8, Q9UC50, Q9UC51	Gene names	HSD11B2, HSD11K
Domain Architecture
Description	Corticosteroid 11-beta-dehydrogenase isozyme 2 (EC 1.1.1.-) (11-DH2) (11-beta-hydroxysteroid dehydrogenase type 2) (11-beta-HSD2) (NAD- dependent 11-beta-hydroxysteroid dehydrogenase).

DHRS3_HUMAN
θ value	0.0330416 (rank : 81)	NC score	0.397831 (rank : 44)
Query Neighborhood Hits	118	Target Neighborhood Hits	73	Shared Neighborhood Hits	64
SwissProt Accessions	O75911, Q6UY38, Q9BUC8	Gene names	DHRS3
Domain Architecture
Description	Short-chain dehydrogenase/reductase 3 (EC 1.1.-.-) (Retinal short- chain dehydrogenase/reductase 1) (retSDR1) (DD83.1).

DCXR_HUMAN
θ value	0.0431538 (rank : 82)	NC score	0.393989 (rank : 47)
Query Neighborhood Hits	118	Target Neighborhood Hits	78	Shared Neighborhood Hits	65
SwissProt Accessions	Q7Z4W1, Q9BTZ3, Q9UHY9	Gene names	DCXR
Domain Architecture	No domain graphic available
Description	L-xylulose reductase (EC 1.1.1.10) (XR) (Dicarbonyl/L-xylulose reductase) (Kidney dicarbonyl reductase) (kiDCR) (Carbonyl reductase II) (Sperm surface protein P34H).

GAS7_HUMAN
θ value	0.0431538 (rank : 83)	NC score	0.187892 (rank : 114)
Query Neighborhood Hits	118	Target Neighborhood Hits	258	Shared Neighborhood Hits	43
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

BAG3_MOUSE
θ value	0.0563607 (rank : 84)	NC score	0.212043 (rank : 107)
Query Neighborhood Hits	118	Target Neighborhood Hits	513	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

BDH2_HUMAN
θ value	0.0563607 (rank : 85)	NC score	0.371816 (rank : 59)
Query Neighborhood Hits	118	Target Neighborhood Hits	72	Shared Neighborhood Hits	59
SwissProt Accessions	Q9BUT1, Q503A0, Q6IA46, Q6UWD3, Q9H8S8, Q9NRX8	Gene names	BDH2, DHRS6
Domain Architecture	No domain graphic available
Description	3-hydroxybutyrate dehydrogenase type 2 (EC 1.1.1.30) (R-beta- hydroxybutyrate dehydrogenase) (Dehydrogenase/reductase SDR family member 6) (Oxidoreductase UCPA).

PECR_HUMAN
θ value	0.0563607 (rank : 86)	NC score	0.403861 (rank : 40)
Query Neighborhood Hits	118	Target Neighborhood Hits	77	Shared Neighborhood Hits	66
SwissProt Accessions	Q9BY49, Q6IAK9, Q9NRD4, Q9NY60, Q9P1A4	Gene names	PECR
Domain Architecture	No domain graphic available
Description	Peroxisomal trans-2-enoyl-CoA reductase (EC 1.3.1.38) (TERP) (HPDHase) (pVI-ARL) (2,4-dienoyl-CoA reductase-related protein) (DCR-RP).

GAS7_MOUSE
θ value	0.0736092 (rank : 87)	NC score	0.184867 (rank : 115)
Query Neighborhood Hits	118	Target Neighborhood Hits	259	Shared Neighborhood Hits	42
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

BAG3_HUMAN
θ value	0.0961366 (rank : 88)	NC score	0.240514 (rank : 99)
Query Neighborhood Hits	118	Target Neighborhood Hits	314	Shared Neighborhood Hits	36
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

FVT1_HUMAN
θ value	0.163984 (rank : 89)	NC score	0.423564 (rank : 30)
Query Neighborhood Hits	118	Target Neighborhood Hits	71	Shared Neighborhood Hits	63
SwissProt Accessions	Q06136	Gene names	FVT1
Domain Architecture
Description	3-ketodihydrosphingosine reductase precursor (EC 1.1.1.102) (3- dehydrosphinganine reductase) (KDS reductase) (Follicular variant translocation protein 1) (FVT-1).

DHB12_MOUSE
θ value	0.21417 (rank : 90)	NC score	0.348439 (rank : 73)
Query Neighborhood Hits	118	Target Neighborhood Hits	70	Shared Neighborhood Hits	63
SwissProt Accessions	O70503, Q3TID1, Q3U7V9, Q542N3, Q8CI39	Gene names	Hsd17b12, Kik1
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 12 (EC 1.1.1.62) (17-beta-HSD 12) (17- beta-hydroxysteroid dehydrogenase 12) (3-ketoacyl-CoA reductase) (EC 1.3.1.-) (KAR) (KIK-I).

DHB3_HUMAN
θ value	0.21417 (rank : 91)	NC score	0.385503 (rank : 56)
Query Neighborhood Hits	118	Target Neighborhood Hits	69	Shared Neighborhood Hits	61
SwissProt Accessions	P37058	Gene names	HSD17B3, EDH17B3
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 3 (EC 1.1.1.62) (17-beta-HSD 3) (Testicular 17-beta-hydroxysteroid dehydrogenase).

DHR11_HUMAN
θ value	0.21417 (rank : 92)	NC score	0.413627 (rank : 37)
Query Neighborhood Hits	118	Target Neighborhood Hits	74	Shared Neighborhood Hits	65
SwissProt Accessions	Q6UWP2, Q9BUC7, Q9H674	Gene names	ames=UNQ836/PRO1774
Domain Architecture	No domain graphic available
Description	Dehydrogenase/reductase SDR family member 11 precursor (EC 1.-.-.-).

FVT1_MOUSE
θ value	0.21417 (rank : 93)	NC score	0.426744 (rank : 29)
Query Neighborhood Hits	118	Target Neighborhood Hits	68	Shared Neighborhood Hits	62
SwissProt Accessions	Q6GV12	Gene names	Fvt1
Domain Architecture	No domain graphic available
Description	3-ketodihydrosphingosine reductase precursor (EC 1.1.1.102) (3- dehydrosphinganine reductase) (KDS reductase) (Follicular variant translocation protein 1) (FVT-1).

DHR11_MOUSE
θ value	0.279714 (rank : 94)	NC score	0.401370 (rank : 42)
Query Neighborhood Hits	118	Target Neighborhood Hits	74	Shared Neighborhood Hits	65
SwissProt Accessions	Q3U0B3, Q5SXB3, Q8R249	Gene names
Domain Architecture	No domain graphic available
Description	Dehydrogenase/reductase SDR family member 11 precursor (EC 1.-.-.-).

WBP4_MOUSE
θ value	0.279714 (rank : 95)	NC score	0.101674 (rank : 130)
Query Neighborhood Hits	118	Target Neighborhood Hits	100	Shared Neighborhood Hits	28
SwissProt Accessions	Q61048, Q8K1Z9, Q9CS45	Gene names	Wbp4, Fbp21, Fnbp21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

PRP40_MOUSE
θ value	0.365318 (rank : 96)	NC score	0.125301 (rank : 128)
Query Neighborhood Hits	118	Target Neighborhood Hits	447	Shared Neighborhood Hits	34
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

BANK1_MOUSE
θ value	0.47712 (rank : 97)	NC score	0.042514 (rank : 140)
Query Neighborhood Hits	118	Target Neighborhood Hits	63	Shared Neighborhood Hits	3
SwissProt Accessions	Q80VH0, Q3U178, Q8BRV6, Q8BRY8	Gene names	Bank1
Domain Architecture	No domain graphic available
Description	B-cell scaffold protein with ankyrin repeats (Protein AVIEF).

DHB2_MOUSE
θ value	0.47712 (rank : 98)	NC score	0.362186 (rank : 64)
Query Neighborhood Hits	118	Target Neighborhood Hits	75	Shared Neighborhood Hits	61
SwissProt Accessions	P51658, O08898	Gene names	Hsd17b2, Edh17b2
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 2 (EC 1.1.1.62) (17-beta-HSD 2) (17- beta-hydroxysteroid dehydrogenase 2).

PRP40_HUMAN
θ value	0.62314 (rank : 99)	NC score	0.125557 (rank : 127)
Query Neighborhood Hits	118	Target Neighborhood Hits	442	Shared Neighborhood Hits	35
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

DHB1_MOUSE
θ value	1.06291 (rank : 100)	NC score	0.344922 (rank : 77)
Query Neighborhood Hits	118	Target Neighborhood Hits	68	Shared Neighborhood Hits	59
SwissProt Accessions	P51656	Gene names	Hsd17b1, Edh17b1
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 1 (EC 1.1.1.62) (17-beta- hydroxysteroid dehydrogenase type 1) (17-beta-HSD 1).

DRP2_HUMAN
θ value	1.06291 (rank : 101)	NC score	0.069949 (rank : 134)
Query Neighborhood Hits	118	Target Neighborhood Hits	186	Shared Neighborhood Hits	23
SwissProt Accessions	Q13474	Gene names	DRP2
Domain Architecture
Description	Dystrophin-related protein 2.

DHB3_MOUSE
θ value	1.81305 (rank : 102)	NC score	0.331753 (rank : 83)
Query Neighborhood Hits	118	Target Neighborhood Hits	67	Shared Neighborhood Hits	59
SwissProt Accessions	P70385	Gene names	Hsd17b3, Edh17b3
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 3 (EC 1.1.1.62) (17-beta-HSD 3) (Testicular 17-beta-hydroxysteroid dehydrogenase).

DMD_HUMAN
θ value	1.81305 (rank : 103)	NC score	0.032027 (rank : 141)
Query Neighborhood Hits	118	Target Neighborhood Hits	1135	Shared Neighborhood Hits	33
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

DMD_MOUSE
θ value	1.81305 (rank : 104)	NC score	0.029917 (rank : 142)
Query Neighborhood Hits	118	Target Neighborhood Hits	1111	Shared Neighborhood Hits	33
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

DECR_MOUSE
θ value	2.36792 (rank : 105)	NC score	0.329498 (rank : 85)
Query Neighborhood Hits	118	Target Neighborhood Hits	66	Shared Neighborhood Hits	60
SwissProt Accessions	Q9CQ62, Q9DCI7	Gene names	Decr1
Domain Architecture	No domain graphic available
Description	2,4-dienoyl-CoA reductase, mitochondrial precursor (EC 1.3.1.34) (2,4- dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH]).

SETD2_HUMAN
θ value	2.36792 (rank : 106)	NC score	0.081694 (rank : 131)
Query Neighborhood Hits	118	Target Neighborhood Hits	412	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

DECR_HUMAN
θ value	3.0926 (rank : 107)	NC score	0.317427 (rank : 88)
Query Neighborhood Hits	118	Target Neighborhood Hits	66	Shared Neighborhood Hits	59
SwissProt Accessions	Q16698, Q93085	Gene names	DECR1, DECR
Domain Architecture
Description	2,4-dienoyl-CoA reductase, mitochondrial precursor (EC 1.3.1.34) (2,4- dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH]).

RHG12_MOUSE
θ value	3.0926 (rank : 108)	NC score	0.061978 (rank : 136)
Query Neighborhood Hits	118	Target Neighborhood Hits	204	Shared Neighborhood Hits	31
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

TCRG1_HUMAN
θ value	4.03905 (rank : 109)	NC score	0.047056 (rank : 138)
Query Neighborhood Hits	118	Target Neighborhood Hits	929	Shared Neighborhood Hits	30
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

TCRG1_MOUSE
θ value	4.03905 (rank : 110)	NC score	0.046986 (rank : 139)
Query Neighborhood Hits	118	Target Neighborhood Hits	947	Shared Neighborhood Hits	31
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

TDPZ3_MOUSE
θ value	4.03905 (rank : 111)	NC score	0.003822 (rank : 147)
Query Neighborhood Hits	118	Target Neighborhood Hits	163	Shared Neighborhood Hits	2
SwissProt Accessions	Q717B4	Gene names	Tdpoz3
Domain Architecture	No domain graphic available
Description	TD and POZ domain-containing protein 3.

ZCHC6_HUMAN
θ value	4.03905 (rank : 112)	NC score	0.013476 (rank : 145)
Query Neighborhood Hits	118	Target Neighborhood Hits	142	Shared Neighborhood Hits	3
SwissProt Accessions	Q5VYS8, Q5H9T0, Q5VYS5, Q5VYS7, Q658Z9, Q659A2, Q6MZJ3, Q8N5F0, Q96N57, Q96NE8, Q9C0F2, Q9H8M6	Gene names	ZCCHC6, KIAA1711
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 6.

DHB2_HUMAN
θ value	5.27518 (rank : 113)	NC score	0.336215 (rank : 79)
Query Neighborhood Hits	118	Target Neighborhood Hits	72	Shared Neighborhood Hits	63
SwissProt Accessions	P37059	Gene names	HSD17B2, EDH17B2
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 2 (EC 1.1.1.62) (17-beta-HSD 2) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (20 alpha- hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH).

RT4I1_HUMAN
θ value	5.27518 (rank : 114)	NC score	0.014011 (rank : 144)
Query Neighborhood Hits	118	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WWV3, Q8N9B3, Q8WZ66, Q9BRA4	Gene names	RTN4IP1, NIMP
Domain Architecture	No domain graphic available
Description	Reticulon-4-interacting protein 1, mitochondrial precursor (NOGO- interacting mitochondrial protein).

UTRO_HUMAN
θ value	5.27518 (rank : 115)	NC score	0.026753 (rank : 143)
Query Neighborhood Hits	118	Target Neighborhood Hits	960	Shared Neighborhood Hits	30
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

HCD2_HUMAN
θ value	6.88961 (rank : 116)	NC score	0.296831 (rank : 91)
Query Neighborhood Hits	118	Target Neighborhood Hits	73	Shared Neighborhood Hits	63
SwissProt Accessions	Q99714, Q8TCV9, Q96HD5	Gene names	HADH2, ERAB, HSD17B10, SCHAD, XH98G2
Domain Architecture
Description	3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (3-hydroxyacyl- CoA dehydrogenase type II) (Type II HADH) (3-hydroxy-2-methylbutyryl- CoA dehydrogenase) (EC 1.1.1.178) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Short-chain type dehydrogenase/reductase XH98G2).

APBB2_HUMAN
θ value	8.99809 (rank : 117)	NC score	0.070644 (rank : 133)
Query Neighborhood Hits	118	Target Neighborhood Hits	96	Shared Neighborhood Hits	23
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

SI1L3_HUMAN
θ value	8.99809 (rank : 118)	NC score	0.007477 (rank : 146)
Query Neighborhood Hits	118	Target Neighborhood Hits	305	Shared Neighborhood Hits	8
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

APBB2_MOUSE
θ value	θ > 10 (rank : 119)	NC score	0.057548 (rank : 137)
Query Neighborhood Hits	118	Target Neighborhood Hits	88	Shared Neighborhood Hits	19
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

DHB8_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.335132 (rank : 80)
Query Neighborhood Hits	118	Target Neighborhood Hits	71	Shared Neighborhood Hits	62
SwissProt Accessions	Q92506, Q9UIQ1	Gene names	HSD17B8, FABGL, HKE6, RING2
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 8 (EC 1.1.1.62) (17-beta-HSD 8) (17- beta-hydroxysteroid dehydrogenase 8) (Protein Ke6) (Ke-6).

DHB8_MOUSE
θ value	θ > 10 (rank : 121)	NC score	0.203014 (rank : 112)
Query Neighborhood Hits	118	Target Neighborhood Hits	56	Shared Neighborhood Hits	48
SwissProt Accessions	P50171, Q60958, Q60959, Q9Z1W2	Gene names	Hsd17b8, H2-Ke6, Hke6
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 8 (EC 1.1.1.62) (17-beta-HSD 8) (17- beta-hydroxysteroid dehydrogenase 8) (Protein Ke6) (Ke-6).

DHRS1_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.322376 (rank : 86)
Query Neighborhood Hits	118	Target Neighborhood Hits	61	Shared Neighborhood Hits	53
SwissProt Accessions	Q96LJ7, Q8NDG3, Q96B59, Q96CQ5	Gene names	DHRS1
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-).

DHRS1_MOUSE
θ value	θ > 10 (rank : 123)	NC score	0.348536 (rank : 72)
Query Neighborhood Hits	118	Target Neighborhood Hits	67	Shared Neighborhood Hits	60
SwissProt Accessions	Q99L04, Q3THW0, Q9D148	Gene names	Dhrs1, D14ertd484e
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-).

EDD1_HUMAN
θ value	θ > 10 (rank : 124)	NC score	0.147564 (rank : 122)
Query Neighborhood Hits	118	Target Neighborhood Hits	170	Shared Neighborhood Hits	13
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

EDD1_MOUSE
θ value	θ > 10 (rank : 125)	NC score	0.147827 (rank : 121)
Query Neighborhood Hits	118	Target Neighborhood Hits	167	Shared Neighborhood Hits	14
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

HCD2_MOUSE
θ value	θ > 10 (rank : 126)	NC score	0.305462 (rank : 90)
Query Neighborhood Hits	118	Target Neighborhood Hits	65	Shared Neighborhood Hits	57
SwissProt Accessions	O08756	Gene names	Hadh2, Erab, Hsd17b10
Domain Architecture
Description	3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (3-hydroxyacyl- CoA dehydrogenase type II) (Type II HADH) (3-hydroxy-2-methylbutyryl- CoA dehydrogenase) (EC 1.1.1.178) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein).

HECD1_HUMAN
θ value	θ > 10 (rank : 127)	NC score	0.131213 (rank : 126)
Query Neighborhood Hits	118	Target Neighborhood Hits	371	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

HECD2_HUMAN
θ value	θ > 10 (rank : 128)	NC score	0.212883 (rank : 106)
Query Neighborhood Hits	118	Target Neighborhood Hits	41	Shared Neighborhood Hits	13
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_MOUSE
θ value	θ > 10 (rank : 129)	NC score	0.214089 (rank : 105)
Query Neighborhood Hits	118	Target Neighborhood Hits	38	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD3_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.147212 (rank : 123)
Query Neighborhood Hits	118	Target Neighborhood Hits	49	Shared Neighborhood Hits	13
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_MOUSE
θ value	θ > 10 (rank : 131)	NC score	0.149824 (rank : 120)
Query Neighborhood Hits	118	Target Neighborhood Hits	47	Shared Neighborhood Hits	13
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HERC2_HUMAN
θ value	θ > 10 (rank : 132)	NC score	0.138340 (rank : 125)
Query Neighborhood Hits	118	Target Neighborhood Hits	163	Shared Neighborhood Hits	17
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_MOUSE
θ value	θ > 10 (rank : 133)	NC score	0.139913 (rank : 124)
Query Neighborhood Hits	118	Target Neighborhood Hits	167	Shared Neighborhood Hits	17
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC3_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.172956 (rank : 117)
Query Neighborhood Hits	118	Target Neighborhood Hits	62	Shared Neighborhood Hits	13
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

HERC5_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.177887 (rank : 116)
Query Neighborhood Hits	118	Target Neighborhood Hits	66	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HUWE1_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.216374 (rank : 104)
Query Neighborhood Hits	118	Target Neighborhood Hits	443	Shared Neighborhood Hits	14
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	θ > 10 (rank : 137)	NC score	0.216763 (rank : 103)
Query Neighborhood Hits	118	Target Neighborhood Hits	406	Shared Neighborhood Hits	14
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

K0317_HUMAN
θ value	θ > 10 (rank : 138)	NC score	0.224412 (rank : 101)
Query Neighborhood Hits	118	Target Neighborhood Hits	46	Shared Neighborhood Hits	13
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
θ value	θ > 10 (rank : 139)	NC score	0.224314 (rank : 102)
Query Neighborhood Hits	118	Target Neighborhood Hits	43	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

SPRE_HUMAN
θ value	θ > 10 (rank : 140)	NC score	0.072525 (rank : 132)
Query Neighborhood Hits	118	Target Neighborhood Hits	32	Shared Neighborhood Hits	24
SwissProt Accessions	P35270	Gene names	SPR
Domain Architecture
Description	Sepiapterin reductase (EC 1.1.1.153) (SPR).

SPRE_MOUSE
θ value	θ > 10 (rank : 141)	NC score	0.122870 (rank : 129)
Query Neighborhood Hits	118	Target Neighborhood Hits	47	Shared Neighborhood Hits	36
SwissProt Accessions	Q64105, Q63996	Gene names	Spr
Domain Architecture
Description	Sepiapterin reductase (EC 1.1.1.153) (SPR).

TRIPC_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.191733 (rank : 113)
Query Neighborhood Hits	118	Target Neighborhood Hits	319	Shared Neighborhood Hits	17
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

UBE3A_HUMAN
θ value	θ > 10 (rank : 143)	NC score	0.207430 (rank : 108)
Query Neighborhood Hits	118	Target Neighborhood Hits	49	Shared Neighborhood Hits	13
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3A_MOUSE
θ value	θ > 10 (rank : 144)	NC score	0.204711 (rank : 110)
Query Neighborhood Hits	118	Target Neighborhood Hits	47	Shared Neighborhood Hits	13
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

UBE3C_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.204928 (rank : 109)
Query Neighborhood Hits	118	Target Neighborhood Hits	51	Shared Neighborhood Hits	13
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
θ value	θ > 10 (rank : 146)	NC score	0.204179 (rank : 111)
Query Neighborhood Hits	118	Target Neighborhood Hits	48	Shared Neighborhood Hits	13
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

WWC3_HUMAN
θ value	θ > 10 (rank : 147)	NC score	0.067722 (rank : 135)
Query Neighborhood Hits	118	Target Neighborhood Hits	193	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ULE0, Q659C1, Q9BTQ1	Gene names	WWC3, KIAA1280
Domain Architecture	No domain graphic available
Description	WWC family member 3.

Hits sorted by NC score

WWOX_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	118	Target Neighborhood Hits	118	Shared Neighborhood Hits	118
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

WWOX_HUMAN
NC score	0.996602 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	118	Target Neighborhood Hits	115	Shared Neighborhood Hits	113
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

RDH14_HUMAN
NC score	0.819358 (rank : 3)	θ value	1.15895e-47 (rank : 7)
Query Neighborhood Hits	118	Target Neighborhood Hits	76	Shared Neighborhood Hits	65
SwissProt Accessions	Q9HBH5	Gene names	RDH14, PAN2
Domain Architecture
Description	Retinol dehydrogenase 14 (EC 1.1.1.-) (Alcohol dehydrogenase PAN2).

RDH14_MOUSE
NC score	0.816044 (rank : 4)	θ value	5.7518e-47 (rank : 8)
Query Neighborhood Hits	118	Target Neighborhood Hits	74	Shared Neighborhood Hits	64
SwissProt Accessions	Q9ERI6	Gene names	Rdh14
Domain Architecture
Description	Retinol dehydrogenase 14 (EC 1.1.1.-) (Alcohol dehydrogenase PAN2).

RDH12_MOUSE
NC score	0.815223 (rank : 5)	θ value	9.45883e-58 (rank : 3)
Query Neighborhood Hits	118	Target Neighborhood Hits	74	Shared Neighborhood Hits	64
SwissProt Accessions	Q8BYK4, Q91WA5, Q9D1Y4	Gene names	Rdh12
Domain Architecture
Description	Retinol dehydrogenase 12 (EC 1.1.1.-).

RDH12_HUMAN
NC score	0.812596 (rank : 6)	θ value	1.41344e-53 (rank : 4)
Query Neighborhood Hits	118	Target Neighborhood Hits	72	Shared Neighborhood Hits	64
SwissProt Accessions	Q96NR8, Q8TAW6	Gene names	RDH12
Domain Architecture
Description	Retinol dehydrogenase 12 (EC 1.1.1.-) (All-trans and 9-cis retinol dehydrogenase).

RDH11_MOUSE
NC score	0.805910 (rank : 7)	θ value	2.75849e-49 (rank : 5)
Query Neighborhood Hits	118	Target Neighborhood Hits	69	Shared Neighborhood Hits	65
SwissProt Accessions	Q9QYF1, Q3UXM9, Q9D0U5	Gene names	Rdh11, Arsdr1, Mdt1, Psdr1
Domain Architecture
Description	Retinol dehydrogenase 11 (EC 1.1.1.-) (Retinal reductase 1) (RalR1) (Prostate short-chain dehydrogenase/reductase 1) (Androgen-regulated short-chain dehydrogenase/reductase 1) (Short-chain aldehyde dehydrogenase) (SCALD) (Cell line MC/9.IL4-derived protein 1) (M42C60).

DHRSX_HUMAN
NC score	0.803492 (rank : 8)	θ value	6.15952e-41 (rank : 11)
Query Neighborhood Hits	118	Target Neighborhood Hits	71	Shared Neighborhood Hits	61
SwissProt Accessions	Q8N5I4, Q6UWC7, Q8WUS4, Q96GR8, Q9NTF6	Gene names	DHRSX, CXorf11, DHRS5X
Domain Architecture
Description	Dehydrogenase/reductase SDR family member on chromosome X precursor (EC 1.1.-.-) (DHRSXY).

RDH13_HUMAN
NC score	0.803474 (rank : 9)	θ value	8.30557e-46 (rank : 9)
Query Neighborhood Hits	118	Target Neighborhood Hits	74	Shared Neighborhood Hits	66
SwissProt Accessions	Q8NBN7, Q6UX79, Q96G88	Gene names	RDH13
Domain Architecture
Description	Retinol dehydrogenase 13 (EC 1.1.1.-).

RDH11_HUMAN
NC score	0.803034 (rank : 10)	θ value	3.60269e-49 (rank : 6)
Query Neighborhood Hits	118	Target Neighborhood Hits	71	Shared Neighborhood Hits	65
SwissProt Accessions	Q8TC12, Q9NRW0, Q9Y391	Gene names	RDH11, ARSDR1, PSDR1
Domain Architecture
Description	Retinol dehydrogenase 11 (EC 1.1.1.-) (Retinal reductase 1) (RalR1) (Prostate short-chain dehydrogenase/reductase 1) (Androgen-regulated short-chain dehydrogenase/reductase 1) (HCV core-binding protein HCBP12).

RDH13_MOUSE
NC score	0.799093 (rank : 11)	θ value	1.41672e-45 (rank : 10)
Query Neighborhood Hits	118	Target Neighborhood Hits	75	Shared Neighborhood Hits	66
SwissProt Accessions	Q8CEE7, Q8CC07	Gene names	Rdh13
Domain Architecture
Description	Retinol dehydrogenase 13 (EC 1.1.1.-).

DHB7_HUMAN
NC score	0.627110 (rank : 12)	θ value	6.20254e-17 (rank : 12)
Query Neighborhood Hits	118	Target Neighborhood Hits	49	Shared Neighborhood Hits	42
SwissProt Accessions	P56937, Q7Z4V9, Q8WWS2, Q9UF00	Gene names	HSD17B7
Domain Architecture
Description	3-keto-steroid reductase (EC 1.1.1.270) (Estradiol 17-beta- dehydrogenase 7) (EC 1.1.1.62) (17-beta-HSD 7) (17-beta-hydroxysteroid dehydrogenase 7).

DHB7_MOUSE
NC score	0.614877 (rank : 13)	θ value	6.85773e-16 (rank : 13)
Query Neighborhood Hits	118	Target Neighborhood Hits	42	Shared Neighborhood Hits	37
SwissProt Accessions	O88736, Q8K5C9, Q921L1	Gene names	Hsd17b7
Domain Architecture
Description	3-keto-steroid reductase (EC 1.1.1.270) (Estradiol 17-beta- dehydrogenase 7) (EC 1.1.1.62) (17-beta-HSD 7) (17-beta-hydroxysteroid dehydrogenase 7).

DHRS7_MOUSE
NC score	0.489211 (rank : 14)	θ value	0.000461057 (rank : 53)
Query Neighborhood Hits	118	Target Neighborhood Hits	75	Shared Neighborhood Hits	66
SwissProt Accessions	Q9CXR1	Gene names	Dhrs7, Retsdr4
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 7 precursor (EC 1.1.-.-) (Retinal short-chain dehydrogenase/reductase 4).

DHRS8_HUMAN
NC score	0.486711 (rank : 15)	θ value	1.17247e-07 (rank : 33)
Query Neighborhood Hits	118	Target Neighborhood Hits	68	Shared Neighborhood Hits	64
SwissProt Accessions	Q8NBQ5, Q96HF6, Q9UKU4	Gene names	DHRS8, HSD17B11, PAN1B
Domain Architecture	No domain graphic available
Description	Dehydrogenase/reductase SDR family member 8 precursor (EC 1.1.1.-) (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17-beta- HSD XI) (17betaHSDXI) (17bHSD11) (17betaHSD11) (Retinal short-chain dehydrogenase/reductase 2) (retSDR2) (Cutaneous T-cell lymphoma- associated antigen HD-CL-03) (CTCL tumor antigen HD-CL-03).

DHC3_HUMAN
NC score	0.480097 (rank : 16)	θ value	0.00228821 (rank : 66)
Query Neighborhood Hits	118	Target Neighborhood Hits	67	Shared Neighborhood Hits	60
SwissProt Accessions	O75828	Gene names	CBR3
Domain Architecture
Description	Carbonyl reductase [NADPH] 3 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 3).

DHRS7_HUMAN
NC score	0.478664 (rank : 17)	θ value	0.00020696 (rank : 48)
Query Neighborhood Hits	118	Target Neighborhood Hits	73	Shared Neighborhood Hits	66
SwissProt Accessions	Q9Y394, Q9UKU2	Gene names	DHRS7, RETSDR4
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 7 precursor (EC 1.1.-.-) (Retinal short-chain dehydrogenase/reductase 4) (retSDR4).

DHRS8_MOUSE
NC score	0.471742 (rank : 18)	θ value	1.69304e-06 (rank : 41)
Query Neighborhood Hits	118	Target Neighborhood Hits	72	Shared Neighborhood Hits	64
SwissProt Accessions	Q9EQ06, Q3U2P6, Q8BR33, Q8C7S0	Gene names	Dhrs8, Hsd17b11, Pan1b
Domain Architecture	No domain graphic available
Description	Dehydrogenase/reductase SDR family member 8 precursor (EC 1.1.1.-) (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17-beta- HSD XI) (17betaHSDXI) (17bHSD11) (17betaHSD11).

DHCA_HUMAN
NC score	0.467951 (rank : 19)	θ value	0.00102713 (rank : 59)
Query Neighborhood Hits	118	Target Neighborhood Hits	63	Shared Neighborhood Hits	58
SwissProt Accessions	P16152	Gene names	CBR1, CBR, CRN
Domain Architecture
Description	Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 1) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) (Prostaglandin 9-ketoreductase) (15-hydroxyprostaglandin dehydrogenase [NADP+]) (EC 1.1.1.197).

DHB13_MOUSE
NC score	0.462401 (rank : 20)	θ value	5.81887e-07 (rank : 36)
Query Neighborhood Hits	118	Target Neighborhood Hits	69	Shared Neighborhood Hits	63
SwissProt Accessions	Q8VCR2, Q8CIU2	Gene names	Hsd17b13, Scdr9
Domain Architecture	No domain graphic available
Description	17-beta hydroxysteroid dehydrogenase 13 precursor (EC 1.1.-.-) (Short- chain dehydrogenase/reductase 9) (Alcohol dehydrogenase PAN1B-like).

YAP1_MOUSE
NC score	0.454873 (rank : 21)	θ value	1.74796e-11 (rank : 22)
Query Neighborhood Hits	118	Target Neighborhood Hits	96	Shared Neighborhood Hits	48
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

DHCA_MOUSE
NC score	0.452140 (rank : 22)	θ value	0.00665767 (rank : 72)
Query Neighborhood Hits	118	Target Neighborhood Hits	61	Shared Neighborhood Hits	55
SwissProt Accessions	P48758	Gene names	Cbr1, Cbr
Domain Architecture
Description	Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 1).

DHB13_HUMAN
NC score	0.449897 (rank : 23)	θ value	1.43324e-05 (rank : 43)
Query Neighborhood Hits	118	Target Neighborhood Hits	70	Shared Neighborhood Hits	61
SwissProt Accessions	Q7Z5P4, Q86W22, Q86W23	Gene names	HSD17B13, SCDR9
Domain Architecture	No domain graphic available
Description	17-beta hydroxysteroid dehydrogenase 13 precursor (EC 1.1.-.-) (Short- chain dehydrogenase/reductase 9).

PGDH_MOUSE
NC score	0.448661 (rank : 24)	θ value	0.000602161 (rank : 56)
Query Neighborhood Hits	118	Target Neighborhood Hits	73	Shared Neighborhood Hits	63
SwissProt Accessions	Q8VCC1, Q61106	Gene names	Hpgd, Pgdh1
Domain Architecture	No domain graphic available
Description	15-hydroxyprostaglandin dehydrogenase [NAD+] (EC 1.1.1.141) (PGDH) (Prostaglandin dehydrogenase 1).

SAV1_HUMAN
NC score	0.446930 (rank : 25)	θ value	2.36244e-08 (rank : 31)
Query Neighborhood Hits	118	Target Neighborhood Hits	51	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SAV1_MOUSE
NC score	0.445957 (rank : 26)	θ value	3.08544e-08 (rank : 32)
Query Neighborhood Hits	118	Target Neighborhood Hits	48	Shared Neighborhood Hits	40
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

PGDH_HUMAN
NC score	0.429789 (rank : 27)	θ value	0.00665767 (rank : 74)
Query Neighborhood Hits	118	Target Neighborhood Hits	73	Shared Neighborhood Hits	62
SwissProt Accessions	P15428	Gene names	HPGD, PGDH1
Domain Architecture
Description	15-hydroxyprostaglandin dehydrogenase [NAD+] (EC 1.1.1.141) (PGDH) (Prostaglandin dehydrogenase 1).

DHI1_HUMAN
NC score	0.428506 (rank : 28)	θ value	0.00134147 (rank : 62)
Query Neighborhood Hits	118	Target Neighborhood Hits	72	Shared Neighborhood Hits	63
SwissProt Accessions	P28845	Gene names	HSD11B1, HSD11, HSD11L
Domain Architecture
Description	Corticosteroid 11-beta-dehydrogenase isozyme 1 (EC 1.1.1.146) (11-DH) (11-beta-hydroxysteroid dehydrogenase 1) (11-beta-HSD1).

FVT1_MOUSE
NC score	0.426744 (rank : 29)	θ value	0.21417 (rank : 93)
Query Neighborhood Hits	118	Target Neighborhood Hits	68	Shared Neighborhood Hits	62
SwissProt Accessions	Q6GV12	Gene names	Fvt1
Domain Architecture	No domain graphic available
Description	3-ketodihydrosphingosine reductase precursor (EC 1.1.1.102) (3- dehydrosphinganine reductase) (KDS reductase) (Follicular variant translocation protein 1) (FVT-1).

FVT1_HUMAN
NC score	0.423564 (rank : 30)	θ value	0.163984 (rank : 89)
Query Neighborhood Hits	118	Target Neighborhood Hits	71	Shared Neighborhood Hits	63
SwissProt Accessions	Q06136	Gene names	FVT1
Domain Architecture
Description	3-ketodihydrosphingosine reductase precursor (EC 1.1.1.102) (3- dehydrosphinganine reductase) (KDS reductase) (Follicular variant translocation protein 1) (FVT-1).

RDH7_MOUSE
NC score	0.422558 (rank : 31)	θ value	0.000786445 (rank : 57)
Query Neighborhood Hits	118	Target Neighborhood Hits	72	Shared Neighborhood Hits	65
SwissProt Accessions	O88451	Gene names	Rdh7, Crad2
Domain Architecture	No domain graphic available
Description	Retinol dehydrogenase 7 (EC 1.1.1.105) (Cis-retinol/androgen dehydrogenase type 2) (CRAD-2) (cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase isozyme 2).

PECR_MOUSE
NC score	0.421405 (rank : 32)	θ value	0.00020696 (rank : 49)
Query Neighborhood Hits	118	Target Neighborhood Hits	73	Shared Neighborhood Hits	66
SwissProt Accessions	Q99MZ7, Q9CX01, Q9JIF4	Gene names	Pecr
Domain Architecture	No domain graphic available
Description	Peroxisomal trans-2-enoyl-CoA reductase (EC 1.3.1.38).

RDH1_HUMAN
NC score	0.420050 (rank : 33)	θ value	7.1131e-05 (rank : 46)
Query Neighborhood Hits	118	Target Neighborhood Hits	68	Shared Neighborhood Hits	59
SwissProt Accessions	Q92781, Q8TAI2	Gene names	RDH5, RDH1
Domain Architecture
Description	11-cis retinol dehydrogenase (EC 1.1.1.105) (11-cis RDH).

DHRS9_HUMAN
NC score	0.418548 (rank : 34)	θ value	7.1131e-05 (rank : 45)
Query Neighborhood Hits	118	Target Neighborhood Hits	65	Shared Neighborhood Hits	60
SwissProt Accessions	Q9BPW9, Q5RKX1, Q9NRA9, Q9NRB0	Gene names	DHRS9
Domain Architecture	No domain graphic available
Description	Dehydrogenase/reductase SDR family member 9 precursor (EC 1.1.-.-) (3- alpha hydroxysteroid dehydrogenase) (3alpha-HSD) (RDH-E2) (Short-chain dehydrogenase/reductase retSDR8) (NADP-dependent retinol dehydrogenase/reductase) (RDHL).

DHRS9_MOUSE
NC score	0.415330 (rank : 35)	θ value	0.00509761 (rank : 71)
Query Neighborhood Hits	118	Target Neighborhood Hits	70	Shared Neighborhood Hits	62
SwissProt Accessions	Q58NB6, Q8BGC7	Gene names	Dhrs9
Domain Architecture	No domain graphic available
Description	Dehydrogenase/reductase SDR family member 9 precursor (EC 1.1.-.-) (3- alpha hydroxysteroid dehydrogenase) (3alpha-HSD) (Short-chain dehydrogenase/reductase retSDR8).

CBR2_MOUSE
NC score	0.414492 (rank : 36)	θ value	0.00175202 (rank : 64)
Query Neighborhood Hits	118	Target Neighborhood Hits	75	Shared Neighborhood Hits	63
SwissProt Accessions	P08074	Gene names	Cbr2
Domain Architecture
Description	Lung carbonyl reductase [NADPH] (EC 1.1.1.184) (NADPH-dependent carbonyl reductase) (LCR) (Adipocyte P27 protein) (AP27).

DHR11_HUMAN
NC score	0.413627 (rank : 37)	θ value	0.21417 (rank : 92)
Query Neighborhood Hits	118	Target Neighborhood Hits	74	Shared Neighborhood Hits	65
SwissProt Accessions	Q6UWP2, Q9BUC7, Q9H674	Gene names	ames=UNQ836/PRO1774
Domain Architecture	No domain graphic available
Description	Dehydrogenase/reductase SDR family member 11 precursor (EC 1.-.-.-).

DHR10_HUMAN
NC score	0.407870 (rank : 38)	θ value	0.00665767 (rank : 73)
Query Neighborhood Hits	118	Target Neighborhood Hits	71	Shared Neighborhood Hits	64
SwissProt Accessions	Q9BPX1, Q9UKU3	Gene names	DHRS10, SDR3
Domain Architecture	No domain graphic available
Description	Dehydrogenase/reductase SDR family member 10 (EC 1.1.-.-) (Retinal short-chain dehydrogenase/reductase retSDR3).

BDH2_MOUSE
NC score	0.406339 (rank : 39)	θ value	0.0252991 (rank : 78)
Query Neighborhood Hits	118	Target Neighborhood Hits	70	Shared Neighborhood Hits	60
SwissProt Accessions	Q8JZV9	Gene names	Bdh2, Dhrs6
Domain Architecture	No domain graphic available
Description	3-hydroxybutyrate dehydrogenase type 2 (EC 1.1.1.30) (R-beta- hydroxybutyrate dehydrogenase) (Dehydrogenase/reductase SDR family member 6).

PECR_HUMAN
NC score	0.403861 (rank : 40)	θ value	0.0563607 (rank : 86)
Query Neighborhood Hits	118	Target Neighborhood Hits	77	Shared Neighborhood Hits	66
SwissProt Accessions	Q9BY49, Q6IAK9, Q9NRD4, Q9NY60, Q9P1A4	Gene names	PECR
Domain Architecture	No domain graphic available
Description	Peroxisomal trans-2-enoyl-CoA reductase (EC 1.3.1.38) (TERP) (HPDHase) (pVI-ARL) (2,4-dienoyl-CoA reductase-related protein) (DCR-RP).

DHI1_MOUSE
NC score	0.403469 (rank : 41)	θ value	0.000602161 (rank : 54)
Query Neighborhood Hits	118	Target Neighborhood Hits	78	Shared Neighborhood Hits	63
SwissProt Accessions	P50172	Gene names	Hsd11b1, Hsd11
Domain Architecture
Description	Corticosteroid 11-beta-dehydrogenase isozyme 1 (EC 1.1.1.146) (11-DH) (11-beta-hydroxysteroid dehydrogenase 1) (11-beta-HSD1) (11beta- HSD1A).

DHR11_MOUSE
NC score	0.401370 (rank : 42)	θ value	0.279714 (rank : 94)
Query Neighborhood Hits	118	Target Neighborhood Hits	74	Shared Neighborhood Hits	65
SwissProt Accessions	Q3U0B3, Q5SXB3, Q8R249	Gene names
Domain Architecture	No domain graphic available
Description	Dehydrogenase/reductase SDR family member 11 precursor (EC 1.-.-.-).

DHRS3_MOUSE
NC score	0.399633 (rank : 43)	θ value	0.0193708 (rank : 77)
Query Neighborhood Hits	118	Target Neighborhood Hits	74	Shared Neighborhood Hits	64
SwissProt Accessions	O88876, Q3UAD1, Q91WR0, Q91XC3, Q922A6	Gene names	Dhrs3, Rsdr1
Domain Architecture
Description	Short-chain dehydrogenase/reductase 3 (EC 1.1.-.-) (Retinal short- chain dehydrogenase/reductase 1) (retSDR1).

DHRS3_HUMAN
NC score	0.397831 (rank : 44)	θ value	0.0330416 (rank : 81)
Query Neighborhood Hits	118	Target Neighborhood Hits	73	Shared Neighborhood Hits	64
SwissProt Accessions	O75911, Q6UY38, Q9BUC8	Gene names	DHRS3
Domain Architecture
Description	Short-chain dehydrogenase/reductase 3 (EC 1.1.-.-) (Retinal short- chain dehydrogenase/reductase 1) (retSDR1) (DD83.1).

WWP2_MOUSE
NC score	0.395927 (rank : 45)	θ value	4.16044e-13 (rank : 17)
Query Neighborhood Hits	118	Target Neighborhood Hits	118	Shared Neighborhood Hits	49
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

WWP2_HUMAN
NC score	0.394927 (rank : 46)	θ value	4.16044e-13 (rank : 16)
Query Neighborhood Hits	118	Target Neighborhood Hits	177	Shared Neighborhood Hits	49
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

DCXR_HUMAN
NC score	0.393989 (rank : 47)	θ value	0.0431538 (rank : 82)
Query Neighborhood Hits	118	Target Neighborhood Hits	78	Shared Neighborhood Hits	65
SwissProt Accessions	Q7Z4W1, Q9BTZ3, Q9UHY9	Gene names	DCXR
Domain Architecture	No domain graphic available
Description	L-xylulose reductase (EC 1.1.1.10) (XR) (Dicarbonyl/L-xylulose reductase) (Kidney dicarbonyl reductase) (kiDCR) (Carbonyl reductase II) (Sperm surface protein P34H).

WWP1_MOUSE
NC score	0.393572 (rank : 48)	θ value	1.74796e-11 (rank : 21)
Query Neighborhood Hits	118	Target Neighborhood Hits	138	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

ITCH_MOUSE
NC score	0.393406 (rank : 49)	θ value	6.41864e-14 (rank : 15)
Query Neighborhood Hits	118	Target Neighborhood Hits	127	Shared Neighborhood Hits	47
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

DHRS2_HUMAN
NC score	0.391439 (rank : 50)	θ value	0.000602161 (rank : 55)
Query Neighborhood Hits	118	Target Neighborhood Hits	72	Shared Neighborhood Hits	65
SwissProt Accessions	Q13268, Q9H2R2	Gene names	DHRS2
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 2 (EC 1.1.-.-) (HEP27 protein) (Protein D).

DECR2_HUMAN
NC score	0.391259 (rank : 51)	θ value	9.92553e-07 (rank : 37)
Query Neighborhood Hits	118	Target Neighborhood Hits	65	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NUI1, Q6ZRS7, Q96ET0	Gene names	DECR2, PDCR
Domain Architecture	No domain graphic available
Description	Peroxisomal 2,4-dienoyl-CoA reductase (EC 1.3.1.34) (2,4-dienoyl-CoA reductase 2) (pDCR).

ITCH_HUMAN
NC score	0.390983 (rank : 52)	θ value	6.41864e-14 (rank : 14)
Query Neighborhood Hits	118	Target Neighborhood Hits	162	Shared Neighborhood Hits	47
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

WWP1_HUMAN
NC score	0.389404 (rank : 53)	θ value	1.02475e-11 (rank : 20)
Query Neighborhood Hits	118	Target Neighborhood Hits	262	Shared Neighborhood Hits	49
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

DCXR_MOUSE
NC score	0.387710 (rank : 54)	θ value	0.00228821 (rank : 65)
Query Neighborhood Hits	118	Target Neighborhood Hits	71	Shared Neighborhood Hits	62
SwissProt Accessions	Q91X52, Q3U5L5, Q9D129, Q9D8W1	Gene names	Dcxr
Domain Architecture	No domain graphic available
Description	L-xylulose reductase (EC 1.1.1.10) (XR) (Dicarbonyl/L-xylulose reductase).

DHRS4_HUMAN
NC score	0.386661 (rank : 55)	θ value	4.92598e-06 (rank : 42)
Query Neighborhood Hits	118	Target Neighborhood Hits	70	Shared Neighborhood Hits	63
SwissProt Accessions	Q9BTZ2, O95162, Q6UWU3, Q8TD03, Q9H3N5, Q9NV08	Gene names	DHRS4
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (NADPH- dependent carbonyl reductase/NADP-retinol dehydrogenase) (CR) (PHCR) (Peroxisomal short-chain alcohol dehydrogenase) (NADPH-dependent retinol dehydrogenase/reductase) (NDRD) (SCAD-SRL) (humNRDR) (PSCD).

DHB3_HUMAN
NC score	0.385503 (rank : 56)	θ value	0.21417 (rank : 91)
Query Neighborhood Hits	118	Target Neighborhood Hits	69	Shared Neighborhood Hits	61
SwissProt Accessions	P37058	Gene names	HSD17B3, EDH17B3
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 3 (EC 1.1.1.62) (17-beta-HSD 3) (Testicular 17-beta-hydroxysteroid dehydrogenase).

BDH_MOUSE
NC score	0.378543 (rank : 57)	θ value	0.000270298 (rank : 50)
Query Neighborhood Hits	118	Target Neighborhood Hits	70	Shared Neighborhood Hits	62
SwissProt Accessions	Q80XN0, Q3UJS9, Q8BK53, Q8R0C8	Gene names	Bdh1, Bdh
Domain Architecture	No domain graphic available
Description	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor (EC 1.1.1.30) (BDH) (3-hydroxybutyrate dehydrogenase).

WWC1_HUMAN
NC score	0.373264 (rank : 58)	θ value	1.25267e-09 (rank : 29)
Query Neighborhood Hits	118	Target Neighborhood Hits	290	Shared Neighborhood Hits	41
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

BDH2_HUMAN
NC score	0.371816 (rank : 59)	θ value	0.0563607 (rank : 85)
Query Neighborhood Hits	118	Target Neighborhood Hits	72	Shared Neighborhood Hits	59
SwissProt Accessions	Q9BUT1, Q503A0, Q6IA46, Q6UWD3, Q9H8S8, Q9NRX8	Gene names	BDH2, DHRS6
Domain Architecture	No domain graphic available
Description	3-hydroxybutyrate dehydrogenase type 2 (EC 1.1.1.30) (R-beta- hydroxybutyrate dehydrogenase) (Dehydrogenase/reductase SDR family member 6) (Oxidoreductase UCPA).

DHB12_HUMAN
NC score	0.371164 (rank : 60)	θ value	0.00869519 (rank : 75)
Query Neighborhood Hits	118	Target Neighborhood Hits	69	Shared Neighborhood Hits	62
SwissProt Accessions	Q53GQ0, Q96JU2, Q9Y6G8	Gene names	HSD17B12
Domain Architecture	No domain graphic available
Description	Estradiol 17-beta-dehydrogenase 12 (EC 1.1.1.62) (17-beta-HSD 12) (17- beta-hydroxysteroid dehydrogenase 12) (3-ketoacyl-CoA reductase) (EC 1.3.1.-) (KAR).

WWC1_MOUSE
NC score	0.368829 (rank : 61)	θ value	6.21693e-09 (rank : 30)
Query Neighborhood Hits	118	Target Neighborhood Hits	290	Shared Neighborhood Hits	37
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

SMUF2_HUMAN
NC score	0.367161 (rank : 62)	θ value	9.59137e-10 (rank : 27)
Query Neighborhood Hits	118	Target Neighborhood Hits	142	Shared Neighborhood Hits	45
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

DHRS4_MOUSE
NC score	0.364518 (rank : 63)	θ value	0.00134147 (rank : 63)
Query Neighborhood Hits	118	Target Neighborhood Hits	67	Shared Neighborhood Hits	60
SwissProt Accessions	Q99LB2, Q9EQU4	Gene names	Dhrs4, D14Ucla2
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (NADPH- dependent carbonyl reductase/NADP-retinol dehydrogenase) (CR) (PHCR) (Peroxisomal short-chain alcohol dehydrogenase) (NADPH-dependent retinol dehydrogenase/reductase) (NDRD) (mouNRDR).

DHB2_MOUSE
NC score	0.362186 (rank : 64)	θ value	0.47712 (rank : 98)
Query Neighborhood Hits	118	Target Neighborhood Hits	75	Shared Neighborhood Hits	61
SwissProt Accessions	P51658, O08898	Gene names	Hsd17b2, Edh17b2
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 2 (EC 1.1.1.62) (17-beta-HSD 2) (17- beta-hydroxysteroid dehydrogenase 2).

SMUF1_MOUSE
NC score	0.360687 (rank : 65)	θ value	1.25267e-09 (rank : 28)
Query Neighborhood Hits	118	Target Neighborhood Hits	142	Shared Neighborhood Hits	40
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

NEDD4_MOUSE
NC score	0.359517 (rank : 66)	θ value	1.02475e-11 (rank : 19)
Query Neighborhood Hits	118	Target Neighborhood Hits	212	Shared Neighborhood Hits	49
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

DECR2_MOUSE
NC score	0.359484 (rank : 67)	θ value	1.69304e-06 (rank : 40)
Query Neighborhood Hits	118	Target Neighborhood Hits	63	Shared Neighborhood Hits	56
SwissProt Accessions	Q9WV68	Gene names	Decr2, Pdcr
Domain Architecture	No domain graphic available
Description	Peroxisomal 2,4-dienoyl-CoA reductase (EC 1.3.1.34) (2,4-dienoyl-CoA reductase 2).

NEDD4_HUMAN
NC score	0.356658 (rank : 68)	θ value	2.52405e-10 (rank : 26)
Query Neighborhood Hits	118	Target Neighborhood Hits	214	Shared Neighborhood Hits	48
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

NED4L_HUMAN
NC score	0.354433 (rank : 69)	θ value	1.02475e-11 (rank : 18)
Query Neighborhood Hits	118	Target Neighborhood Hits	238	Shared Neighborhood Hits	49
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_MOUSE
NC score	0.353948 (rank : 70)	θ value	3.89403e-11 (rank : 24)
Query Neighborhood Hits	118	Target Neighborhood Hits	231	Shared Neighborhood Hits	49
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

DHB1_HUMAN
NC score	0.351905 (rank : 71)	θ value	0.0252991 (rank : 79)
Query Neighborhood Hits	118	Target Neighborhood Hits	67	Shared Neighborhood Hits	63
SwissProt Accessions	P14061	Gene names	HSD17B1, E17KSR, EDH17B1, EDHB17
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 1 (EC 1.1.1.62) (17-beta- hydroxysteroid dehydrogenase type 1) (17-beta-HSD 1) (Placental 17- beta-hydroxysteroid dehydrogenase) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH).

DHRS1_MOUSE
NC score	0.348536 (rank : 72)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	118	Target Neighborhood Hits	67	Shared Neighborhood Hits	60
SwissProt Accessions	Q99L04, Q3THW0, Q9D148	Gene names	Dhrs1, D14ertd484e
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-).

DHB12_MOUSE
NC score	0.348439 (rank : 73)	θ value	0.21417 (rank : 90)
Query Neighborhood Hits	118	Target Neighborhood Hits	70	Shared Neighborhood Hits	63
SwissProt Accessions	O70503, Q3TID1, Q3U7V9, Q542N3, Q8CI39	Gene names	Hsd17b12, Kik1
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 12 (EC 1.1.1.62) (17-beta-HSD 12) (17- beta-hydroxysteroid dehydrogenase 12) (3-ketoacyl-CoA reductase) (EC 1.3.1.-) (KAR) (KIK-I).

SMUF1_HUMAN
NC score	0.346824 (rank : 74)	θ value	1.29631e-06 (rank : 39)
Query Neighborhood Hits	118	Target Neighborhood Hits	135	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

DHI2_MOUSE
NC score	0.345628 (rank : 75)	θ value	0.00298849 (rank : 70)
Query Neighborhood Hits	118	Target Neighborhood Hits	65	Shared Neighborhood Hits	58
SwissProt Accessions	P51661, Q91WK3	Gene names	Hsd11b2, Hsd11k
Domain Architecture
Description	Corticosteroid 11-beta-dehydrogenase isozyme 2 (EC 1.1.1.-) (11-DH2) (11-beta-hydroxysteroid dehydrogenase type 2) (11-beta-HSD2) (NAD- dependent 11-beta-hydroxysteroid dehydrogenase).

PINL_HUMAN
NC score	0.345149 (rank : 76)	θ value	0.00228821 (rank : 67)
Query Neighborhood Hits	118	Target Neighborhood Hits	47	Shared Neighborhood Hits	39
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

DHB1_MOUSE
NC score	0.344922 (rank : 77)	θ value	1.06291 (rank : 100)
Query Neighborhood Hits	118	Target Neighborhood Hits	68	Shared Neighborhood Hits	59
SwissProt Accessions	P51656	Gene names	Hsd17b1, Edh17b1
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 1 (EC 1.1.1.62) (17-beta- hydroxysteroid dehydrogenase type 1) (17-beta-HSD 1).

YAP1_HUMAN
NC score	0.342441 (rank : 78)	θ value	4.1701e-05 (rank : 44)
Query Neighborhood Hits	118	Target Neighborhood Hits	173	Shared Neighborhood Hits	46
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

DHB2_HUMAN
NC score	0.336215 (rank : 79)	θ value	5.27518 (rank : 113)
Query Neighborhood Hits	118	Target Neighborhood Hits	72	Shared Neighborhood Hits	63
SwissProt Accessions	P37059	Gene names	HSD17B2, EDH17B2
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 2 (EC 1.1.1.62) (17-beta-HSD 2) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (20 alpha- hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH).

DHB8_HUMAN
NC score	0.335132 (rank : 80)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	118	Target Neighborhood Hits	71	Shared Neighborhood Hits	62
SwissProt Accessions	Q92506, Q9UIQ1	Gene names	HSD17B8, FABGL, HKE6, RING2
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 8 (EC 1.1.1.62) (17-beta-HSD 8) (17- beta-hydroxysteroid dehydrogenase 8) (Protein Ke6) (Ke-6).

WWTR1_MOUSE
NC score	0.334222 (rank : 81)	θ value	0.00102713 (rank : 61)
Query Neighborhood Hits	118	Target Neighborhood Hits	54	Shared Neighborhood Hits	39
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

BDH_HUMAN
NC score	0.332292 (rank : 82)	θ value	0.00035302 (rank : 51)
Query Neighborhood Hits	118	Target Neighborhood Hits	65	Shared Neighborhood Hits	60
SwissProt Accessions	Q02338, Q96ET1, Q9BRZ4	Gene names	BDH1, BDH
Domain Architecture
Description	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor (EC 1.1.1.30) (BDH) (3-hydroxybutyrate dehydrogenase).

DHB3_MOUSE
NC score	0.331753 (rank : 83)	θ value	1.81305 (rank : 102)
Query Neighborhood Hits	118	Target Neighborhood Hits	67	Shared Neighborhood Hits	59
SwissProt Accessions	P70385	Gene names	Hsd17b3, Edh17b3
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 3 (EC 1.1.1.62) (17-beta-HSD 3) (Testicular 17-beta-hydroxysteroid dehydrogenase).

WWTR1_HUMAN
NC score	0.330612 (rank : 84)	θ value	0.00102713 (rank : 60)
Query Neighborhood Hits	118	Target Neighborhood Hits	76	Shared Neighborhood Hits	38
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

DECR_MOUSE
NC score	0.329498 (rank : 85)	θ value	2.36792 (rank : 105)
Query Neighborhood Hits	118	Target Neighborhood Hits	66	Shared Neighborhood Hits	60
SwissProt Accessions	Q9CQ62, Q9DCI7	Gene names	Decr1
Domain Architecture	No domain graphic available
Description	2,4-dienoyl-CoA reductase, mitochondrial precursor (EC 1.3.1.34) (2,4- dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH]).

DHRS1_HUMAN
NC score	0.322376 (rank : 86)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	118	Target Neighborhood Hits	61	Shared Neighborhood Hits	53
SwissProt Accessions	Q96LJ7, Q8NDG3, Q96B59, Q96CQ5	Gene names	DHRS1
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-).

PIN1_MOUSE
NC score	0.320490 (rank : 87)	θ value	0.000121331 (rank : 47)
Query Neighborhood Hits	118	Target Neighborhood Hits	60	Shared Neighborhood Hits	41
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

DECR_HUMAN
NC score	0.317427 (rank : 88)	θ value	3.0926 (rank : 107)
Query Neighborhood Hits	118	Target Neighborhood Hits	66	Shared Neighborhood Hits	59
SwissProt Accessions	Q16698, Q93085	Gene names	DECR1, DECR
Domain Architecture
Description	2,4-dienoyl-CoA reductase, mitochondrial precursor (EC 1.3.1.34) (2,4- dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH]).

PIN1_HUMAN
NC score	0.314322 (rank : 89)	θ value	0.00035302 (rank : 52)
Query Neighborhood Hits	118	Target Neighborhood Hits	59	Shared Neighborhood Hits	40
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

HCD2_MOUSE
NC score	0.305462 (rank : 90)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	118	Target Neighborhood Hits	65	Shared Neighborhood Hits	57
SwissProt Accessions	O08756	Gene names	Hadh2, Erab, Hsd17b10
Domain Architecture
Description	3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (3-hydroxyacyl- CoA dehydrogenase type II) (Type II HADH) (3-hydroxy-2-methylbutyryl- CoA dehydrogenase) (EC 1.1.1.178) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein).

HCD2_HUMAN
NC score	0.296831 (rank : 91)	θ value	6.88961 (rank : 116)
Query Neighborhood Hits	118	Target Neighborhood Hits	73	Shared Neighborhood Hits	63
SwissProt Accessions	Q99714, Q8TCV9, Q96HD5	Gene names	HADH2, ERAB, HSD17B10, SCHAD, XH98G2
Domain Architecture
Description	3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (3-hydroxyacyl- CoA dehydrogenase type II) (Type II HADH) (3-hydroxy-2-methylbutyryl- CoA dehydrogenase) (EC 1.1.1.178) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Short-chain type dehydrogenase/reductase XH98G2).

MAGI2_MOUSE
NC score	0.295190 (rank : 92)	θ value	8.67504e-11 (rank : 25)
Query Neighborhood Hits	118	Target Neighborhood Hits	370	Shared Neighborhood Hits	43
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

DHB4_HUMAN
NC score	0.291727 (rank : 93)	θ value	0.00102713 (rank : 58)
Query Neighborhood Hits	118	Target Neighborhood Hits	83	Shared Neighborhood Hits	59
SwissProt Accessions	P51659	Gene names	HSD17B4, EDH17B4
Domain Architecture
Description	Peroxisomal multifunctional enzyme type 2 (MFE-2) (D-bifunctional protein) (DBP) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-3-hydroxyacyl-CoA dehydratase) (EC 4.2.1.107) (3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase) (3- hydroxyacyl-CoA dehydrogenase) (EC 1.1.1.35).

MAGI2_HUMAN
NC score	0.290156 (rank : 94)	θ value	3.89403e-11 (rank : 23)
Query Neighborhood Hits	118	Target Neighborhood Hits	373	Shared Neighborhood Hits	39
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

DHB4_MOUSE
NC score	0.278420 (rank : 95)	θ value	0.0148317 (rank : 76)
Query Neighborhood Hits	118	Target Neighborhood Hits	78	Shared Neighborhood Hits	59
SwissProt Accessions	P51660, Q9DBM3	Gene names	Hsd17b4, Edh17b4
Domain Architecture
Description	Peroxisomal multifunctional enzyme type 2 (MFE-2) (D-bifunctional protein) (DBP) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-3-hydroxyacyl-CoA dehydratase) (EC 4.2.1.107) (3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase) (3- hydroxyacyl-CoA dehydrogenase) (EC 1.1.1.35).

DHI2_HUMAN
NC score	0.276850 (rank : 96)	θ value	0.0330416 (rank : 80)
Query Neighborhood Hits	118	Target Neighborhood Hits	62	Shared Neighborhood Hits	57
SwissProt Accessions	P80365, Q13194, Q8N439, Q96QN8, Q9UC50, Q9UC51	Gene names	HSD11B2, HSD11K
Domain Architecture
Description	Corticosteroid 11-beta-dehydrogenase isozyme 2 (EC 1.1.1.-) (11-DH2) (11-beta-hydroxysteroid dehydrogenase type 2) (11-beta-HSD2) (NAD- dependent 11-beta-hydroxysteroid dehydrogenase).

MAGI1_HUMAN
NC score	0.266241 (rank : 97)	θ value	3.41135e-07 (rank : 35)
Query Neighborhood Hits	118	Target Neighborhood Hits	388	Shared Neighborhood Hits	45
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI1_MOUSE
NC score	0.265702 (rank : 98)	θ value	2.61198e-07 (rank : 34)
Query Neighborhood Hits	118	Target Neighborhood Hits	403	Shared Neighborhood Hits	46
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

BAG3_HUMAN
NC score	0.240514 (rank : 99)	θ value	0.0961366 (rank : 88)
Query Neighborhood Hits	118	Target Neighborhood Hits	314	Shared Neighborhood Hits	36
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

PKHA5_HUMAN
NC score	0.233243 (rank : 100)	θ value	1.29631e-06 (rank : 38)
Query Neighborhood Hits	118	Target Neighborhood Hits	455	Shared Neighborhood Hits	36
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

K0317_HUMAN
NC score	0.224412 (rank : 101)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	118	Target Neighborhood Hits	46	Shared Neighborhood Hits	13
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
NC score	0.224314 (rank : 102)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	118	Target Neighborhood Hits	43	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

HUWE1_MOUSE
NC score	0.216763 (rank : 103)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	118	Target Neighborhood Hits	406	Shared Neighborhood Hits	14
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

HUWE1_HUMAN
NC score	0.216374 (rank : 104)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	118	Target Neighborhood Hits	443	Shared Neighborhood Hits	14
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HECD2_MOUSE
NC score	0.214089 (rank : 105)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	118	Target Neighborhood Hits	38	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_HUMAN
NC score	0.212883 (rank : 106)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	118	Target Neighborhood Hits	41	Shared Neighborhood Hits	13
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

BAG3_MOUSE
NC score	0.212043 (rank : 107)	θ value	0.0563607 (rank : 84)
Query Neighborhood Hits	118	Target Neighborhood Hits	513	Shared Neighborhood Hits	40
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

UBE3A_HUMAN
NC score	0.207430 (rank : 108)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	118	Target Neighborhood Hits	49	Shared Neighborhood Hits	13
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3C_HUMAN
NC score	0.204928 (rank : 109)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	118	Target Neighborhood Hits	51	Shared Neighborhood Hits	13
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3A_MOUSE
NC score	0.204711 (rank : 110)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	118	Target Neighborhood Hits	47	Shared Neighborhood Hits	13
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

UBE3C_MOUSE
NC score	0.204179 (rank : 111)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	118	Target Neighborhood Hits	48	Shared Neighborhood Hits	13
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

DHB8_MOUSE
NC score	0.203014 (rank : 112)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	118	Target Neighborhood Hits	56	Shared Neighborhood Hits	48
SwissProt Accessions	P50171, Q60958, Q60959, Q9Z1W2	Gene names	Hsd17b8, H2-Ke6, Hke6
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 8 (EC 1.1.1.62) (17-beta-HSD 8) (17- beta-hydroxysteroid dehydrogenase 8) (Protein Ke6) (Ke-6).

TRIPC_HUMAN
NC score	0.191733 (rank : 113)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	118	Target Neighborhood Hits	319	Shared Neighborhood Hits	17
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

GAS7_HUMAN
NC score	0.187892 (rank : 114)	θ value	0.0431538 (rank : 83)
Query Neighborhood Hits	118	Target Neighborhood Hits	258	Shared Neighborhood Hits	43
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

GAS7_MOUSE
NC score	0.184867 (rank : 115)	θ value	0.0736092 (rank : 87)
Query Neighborhood Hits	118	Target Neighborhood Hits	259	Shared Neighborhood Hits	42
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

HERC5_HUMAN
NC score	0.177887 (rank : 116)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	118	Target Neighborhood Hits	66	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HERC3_HUMAN
NC score	0.172956 (rank : 117)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	118	Target Neighborhood Hits	62	Shared Neighborhood Hits	13
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

STXB4_MOUSE
NC score	0.167115 (rank : 118)	θ value	0.00228821 (rank : 69)
Query Neighborhood Hits	118	Target Neighborhood Hits	629	Shared Neighborhood Hits	42
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_HUMAN
NC score	0.165474 (rank : 119)	θ value	0.00228821 (rank : 68)
Query Neighborhood Hits	118	Target Neighborhood Hits	616	Shared Neighborhood Hits	42
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

HECD3_MOUSE
NC score	0.149824 (rank : 120)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	118	Target Neighborhood Hits	47	Shared Neighborhood Hits	13
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

EDD1_MOUSE
NC score	0.147827 (rank : 121)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	118	Target Neighborhood Hits	167	Shared Neighborhood Hits	14
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

EDD1_HUMAN
NC score	0.147564 (rank : 122)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	118	Target Neighborhood Hits	170	Shared Neighborhood Hits	13
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

HECD3_HUMAN
NC score	0.147212 (rank : 123)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	118	Target Neighborhood Hits	49	Shared Neighborhood Hits	13
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HERC2_MOUSE
NC score	0.139913 (rank : 124)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	118	Target Neighborhood Hits	167	Shared Neighborhood Hits	17
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_HUMAN
NC score	0.138340 (rank : 125)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	118	Target Neighborhood Hits	163	Shared Neighborhood Hits	17
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HECD1_HUMAN
NC score	0.131213 (rank : 126)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	118	Target Neighborhood Hits	371	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

PRP40_HUMAN
NC score	0.125557 (rank : 127)	θ value	0.62314 (rank : 99)
Query Neighborhood Hits	118	Target Neighborhood Hits	442	Shared Neighborhood Hits	35
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

PRP40_MOUSE
NC score	0.125301 (rank : 128)	θ value	0.365318 (rank : 96)
Query Neighborhood Hits	118	Target Neighborhood Hits	447	Shared Neighborhood Hits	34
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

SPRE_MOUSE
NC score	0.122870 (rank : 129)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	118	Target Neighborhood Hits	47	Shared Neighborhood Hits	36
SwissProt Accessions	Q64105, Q63996	Gene names	Spr
Domain Architecture
Description	Sepiapterin reductase (EC 1.1.1.153) (SPR).

WBP4_MOUSE
NC score	0.101674 (rank : 130)	θ value	0.279714 (rank : 95)
Query Neighborhood Hits	118	Target Neighborhood Hits	100	Shared Neighborhood Hits	28
SwissProt Accessions	Q61048, Q8K1Z9, Q9CS45	Gene names	Wbp4, Fbp21, Fnbp21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

SETD2_HUMAN
NC score	0.081694 (rank : 131)	θ value	2.36792 (rank : 106)
Query Neighborhood Hits	118	Target Neighborhood Hits	412	Shared Neighborhood Hits	37
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

SPRE_HUMAN
NC score	0.072525 (rank : 132)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	118	Target Neighborhood Hits	32	Shared Neighborhood Hits	24
SwissProt Accessions	P35270	Gene names	SPR
Domain Architecture
Description	Sepiapterin reductase (EC 1.1.1.153) (SPR).

APBB2_HUMAN
NC score	0.070644 (rank : 133)	θ value	8.99809 (rank : 117)
Query Neighborhood Hits	118	Target Neighborhood Hits	96	Shared Neighborhood Hits	23
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

DRP2_HUMAN
NC score	0.069949 (rank : 134)	θ value	1.06291 (rank : 101)
Query Neighborhood Hits	118	Target Neighborhood Hits	186	Shared Neighborhood Hits	23
SwissProt Accessions	Q13474	Gene names	DRP2
Domain Architecture
Description	Dystrophin-related protein 2.

WWC3_HUMAN
NC score	0.067722 (rank : 135)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	118	Target Neighborhood Hits	193	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ULE0, Q659C1, Q9BTQ1	Gene names	WWC3, KIAA1280
Domain Architecture	No domain graphic available
Description	WWC family member 3.

RHG12_MOUSE
NC score	0.061978 (rank : 136)	θ value	3.0926 (rank : 108)
Query Neighborhood Hits	118	Target Neighborhood Hits	204	Shared Neighborhood Hits	31
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

APBB2_MOUSE
NC score	0.057548 (rank : 137)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	118	Target Neighborhood Hits	88	Shared Neighborhood Hits	19
SwissProt Accessions	Q9DBR4, Q6DFX8	Gene names	Apbb2
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2.

TCRG1_HUMAN
NC score	0.047056 (rank : 138)	θ value	4.03905 (rank : 109)
Query Neighborhood Hits	118	Target Neighborhood Hits	929	Shared Neighborhood Hits	30
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

TCRG1_MOUSE
NC score	0.046986 (rank : 139)	θ value	4.03905 (rank : 110)
Query Neighborhood Hits	118	Target Neighborhood Hits	947	Shared Neighborhood Hits	31
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

BANK1_MOUSE
NC score	0.042514 (rank : 140)	θ value	0.47712 (rank : 97)
Query Neighborhood Hits	118	Target Neighborhood Hits	63	Shared Neighborhood Hits	3
SwissProt Accessions	Q80VH0, Q3U178, Q8BRV6, Q8BRY8	Gene names	Bank1
Domain Architecture	No domain graphic available
Description	B-cell scaffold protein with ankyrin repeats (Protein AVIEF).

DMD_HUMAN
NC score	0.032027 (rank : 141)	θ value	1.81305 (rank : 103)
Query Neighborhood Hits	118	Target Neighborhood Hits	1135	Shared Neighborhood Hits	33
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

DMD_MOUSE
NC score	0.029917 (rank : 142)	θ value	1.81305 (rank : 104)
Query Neighborhood Hits	118	Target Neighborhood Hits	1111	Shared Neighborhood Hits	33
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

UTRO_HUMAN
NC score	0.026753 (rank : 143)	θ value	5.27518 (rank : 115)
Query Neighborhood Hits	118	Target Neighborhood Hits	960	Shared Neighborhood Hits	30
SwissProt Accessions	P46939	Gene names	UTRN, DMDL
Domain Architecture
Description	Utrophin (Dystrophin-related protein 1) (DRP1) (DRP).

RT4I1_HUMAN
NC score	0.014011 (rank : 144)	θ value	5.27518 (rank : 114)
Query Neighborhood Hits	118	Target Neighborhood Hits	31	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WWV3, Q8N9B3, Q8WZ66, Q9BRA4	Gene names	RTN4IP1, NIMP
Domain Architecture	No domain graphic available
Description	Reticulon-4-interacting protein 1, mitochondrial precursor (NOGO- interacting mitochondrial protein).

ZCHC6_HUMAN
NC score	0.013476 (rank : 145)	θ value	4.03905 (rank : 112)
Query Neighborhood Hits	118	Target Neighborhood Hits	142	Shared Neighborhood Hits	3
SwissProt Accessions	Q5VYS8, Q5H9T0, Q5VYS5, Q5VYS7, Q658Z9, Q659A2, Q6MZJ3, Q8N5F0, Q96N57, Q96NE8, Q9C0F2, Q9H8M6	Gene names	ZCCHC6, KIAA1711
Domain Architecture	No domain graphic available
Description	Zinc finger CCHC domain-containing protein 6.

SI1L3_HUMAN
NC score	0.007477 (rank : 146)	θ value	8.99809 (rank : 118)
Query Neighborhood Hits	118	Target Neighborhood Hits	305	Shared Neighborhood Hits	8
SwissProt Accessions	O60292, Q2TV87	Gene names	SIPA1L3, KIAA0545, SPAL3
Domain Architecture	No domain graphic available
Description	Signal-induced proliferation-associated 1-like protein 3 (SPA-1-like protein 3).

TDPZ3_MOUSE
NC score	0.003822 (rank : 147)	θ value	4.03905 (rank : 111)
Query Neighborhood Hits	118	Target Neighborhood Hits	163	Shared Neighborhood Hits	2
SwissProt Accessions	Q717B4	Gene names	Tdpoz3
Domain Architecture	No domain graphic available
Description	TD and POZ domain-containing protein 3.