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Network neighborhood for query Sequence : RDH14_MOUSE

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RDH14_MOUSE
SwissProt Accessions	Q9ERI6	Gene names	Rdh14
Domain Architecture
Description	Retinol dehydrogenase 14 (EC 1.1.1.-) (Alcohol dehydrogenase PAN2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

RDH14_MOUSE
θ value	1.46188e-167 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	74
SwissProt Accessions	Q9ERI6	Gene names	Rdh14
Domain Architecture
Description	Retinol dehydrogenase 14 (EC 1.1.1.-) (Alcohol dehydrogenase PAN2).

RDH14_HUMAN
θ value	1.51984e-148 (rank : 2)	NC score	0.994108 (rank : 2)
Query Neighborhood Hits	74	Target Neighborhood Hits	76	Shared Neighborhood Hits	70
SwissProt Accessions	Q9HBH5	Gene names	RDH14, PAN2
Domain Architecture
Description	Retinol dehydrogenase 14 (EC 1.1.1.-) (Alcohol dehydrogenase PAN2).

RDH13_MOUSE
θ value	4.52582e-68 (rank : 3)	NC score	0.955458 (rank : 7)
Query Neighborhood Hits	74	Target Neighborhood Hits	75	Shared Neighborhood Hits	68
SwissProt Accessions	Q8CEE7, Q8CC07	Gene names	Rdh13
Domain Architecture
Description	Retinol dehydrogenase 13 (EC 1.1.1.-).

RDH12_HUMAN
θ value	1.45591e-66 (rank : 4)	NC score	0.958852 (rank : 5)
Query Neighborhood Hits	74	Target Neighborhood Hits	72	Shared Neighborhood Hits	67
SwissProt Accessions	Q96NR8, Q8TAW6	Gene names	RDH12
Domain Architecture
Description	Retinol dehydrogenase 12 (EC 1.1.1.-) (All-trans and 9-cis retinol dehydrogenase).

RDH12_MOUSE
θ value	4.68348e-65 (rank : 5)	NC score	0.962425 (rank : 3)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	67
SwissProt Accessions	Q8BYK4, Q91WA5, Q9D1Y4	Gene names	Rdh12
Domain Architecture
Description	Retinol dehydrogenase 12 (EC 1.1.1.-).

RDH13_HUMAN
θ value	1.04338e-64 (rank : 6)	NC score	0.959609 (rank : 4)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	68
SwissProt Accessions	Q8NBN7, Q6UX79, Q96G88	Gene names	RDH13
Domain Architecture
Description	Retinol dehydrogenase 13 (EC 1.1.1.-).

RDH11_HUMAN
θ value	1.31987e-59 (rank : 7)	NC score	0.953255 (rank : 8)
Query Neighborhood Hits	74	Target Neighborhood Hits	71	Shared Neighborhood Hits	67
SwissProt Accessions	Q8TC12, Q9NRW0, Q9Y391	Gene names	RDH11, ARSDR1, PSDR1
Domain Architecture
Description	Retinol dehydrogenase 11 (EC 1.1.1.-) (Retinal reductase 1) (RalR1) (Prostate short-chain dehydrogenase/reductase 1) (Androgen-regulated short-chain dehydrogenase/reductase 1) (HCV core-binding protein HCBP12).

RDH11_MOUSE
θ value	1.45929e-58 (rank : 8)	NC score	0.957580 (rank : 6)
Query Neighborhood Hits	74	Target Neighborhood Hits	69	Shared Neighborhood Hits	68
SwissProt Accessions	Q9QYF1, Q3UXM9, Q9D0U5	Gene names	Rdh11, Arsdr1, Mdt1, Psdr1
Domain Architecture
Description	Retinol dehydrogenase 11 (EC 1.1.1.-) (Retinal reductase 1) (RalR1) (Prostate short-chain dehydrogenase/reductase 1) (Androgen-regulated short-chain dehydrogenase/reductase 1) (Short-chain aldehyde dehydrogenase) (SCALD) (Cell line MC/9.IL4-derived protein 1) (M42C60).

WWOX_HUMAN
θ value	3.04986e-48 (rank : 9)	NC score	0.811449 (rank : 11)
Query Neighborhood Hits	74	Target Neighborhood Hits	115	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

WWOX_MOUSE
θ value	5.7518e-47 (rank : 10)	NC score	0.816044 (rank : 10)
Query Neighborhood Hits	74	Target Neighborhood Hits	118	Shared Neighborhood Hits	64
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

DHRSX_HUMAN
θ value	1.32601e-43 (rank : 11)	NC score	0.942227 (rank : 9)
Query Neighborhood Hits	74	Target Neighborhood Hits	71	Shared Neighborhood Hits	64
SwissProt Accessions	Q8N5I4, Q6UWC7, Q8WUS4, Q96GR8, Q9NTF6	Gene names	DHRSX, CXorf11, DHRS5X
Domain Architecture
Description	Dehydrogenase/reductase SDR family member on chromosome X precursor (EC 1.1.-.-) (DHRSXY).

DHB7_HUMAN
θ value	1.42992e-13 (rank : 12)	NC score	0.689213 (rank : 12)
Query Neighborhood Hits	74	Target Neighborhood Hits	49	Shared Neighborhood Hits	45
SwissProt Accessions	P56937, Q7Z4V9, Q8WWS2, Q9UF00	Gene names	HSD17B7
Domain Architecture
Description	3-keto-steroid reductase (EC 1.1.1.270) (Estradiol 17-beta- dehydrogenase 7) (EC 1.1.1.62) (17-beta-HSD 7) (17-beta-hydroxysteroid dehydrogenase 7).

DHB7_MOUSE
θ value	1.86753e-13 (rank : 13)	NC score	0.673420 (rank : 13)
Query Neighborhood Hits	74	Target Neighborhood Hits	42	Shared Neighborhood Hits	41
SwissProt Accessions	O88736, Q8K5C9, Q921L1	Gene names	Hsd17b7
Domain Architecture
Description	3-keto-steroid reductase (EC 1.1.1.270) (Estradiol 17-beta- dehydrogenase 7) (EC 1.1.1.62) (17-beta-HSD 7) (17-beta-hydroxysteroid dehydrogenase 7).

DHCA_HUMAN
θ value	6.00763e-12 (rank : 14)	NC score	0.650950 (rank : 15)
Query Neighborhood Hits	74	Target Neighborhood Hits	63	Shared Neighborhood Hits	60
SwissProt Accessions	P16152	Gene names	CBR1, CBR, CRN
Domain Architecture
Description	Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 1) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) (Prostaglandin 9-ketoreductase) (15-hydroxyprostaglandin dehydrogenase [NADP+]) (EC 1.1.1.197).

DHCA_MOUSE
θ value	7.84624e-12 (rank : 15)	NC score	0.628519 (rank : 17)
Query Neighborhood Hits	74	Target Neighborhood Hits	61	Shared Neighborhood Hits	57
SwissProt Accessions	P48758	Gene names	Cbr1, Cbr
Domain Architecture
Description	Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 1).

DHC3_HUMAN
θ value	8.67504e-11 (rank : 16)	NC score	0.661881 (rank : 14)
Query Neighborhood Hits	74	Target Neighborhood Hits	67	Shared Neighborhood Hits	63
SwissProt Accessions	O75828	Gene names	CBR3
Domain Architecture
Description	Carbonyl reductase [NADPH] 3 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 3).

DHRS8_MOUSE
θ value	1.38499e-08 (rank : 17)	NC score	0.603982 (rank : 21)
Query Neighborhood Hits	74	Target Neighborhood Hits	72	Shared Neighborhood Hits	67
SwissProt Accessions	Q9EQ06, Q3U2P6, Q8BR33, Q8C7S0	Gene names	Dhrs8, Hsd17b11, Pan1b
Domain Architecture	No domain graphic available
Description	Dehydrogenase/reductase SDR family member 8 precursor (EC 1.1.1.-) (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17-beta- HSD XI) (17betaHSDXI) (17bHSD11) (17betaHSD11).

DHRS8_HUMAN
θ value	2.36244e-08 (rank : 18)	NC score	0.607699 (rank : 19)
Query Neighborhood Hits	74	Target Neighborhood Hits	68	Shared Neighborhood Hits	66
SwissProt Accessions	Q8NBQ5, Q96HF6, Q9UKU4	Gene names	DHRS8, HSD17B11, PAN1B
Domain Architecture	No domain graphic available
Description	Dehydrogenase/reductase SDR family member 8 precursor (EC 1.1.1.-) (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17-beta- HSD XI) (17betaHSDXI) (17bHSD11) (17betaHSD11) (Retinal short-chain dehydrogenase/reductase 2) (retSDR2) (Cutaneous T-cell lymphoma- associated antigen HD-CL-03) (CTCL tumor antigen HD-CL-03).

DHB2_MOUSE
θ value	6.87365e-08 (rank : 19)	NC score	0.483614 (rank : 52)
Query Neighborhood Hits	74	Target Neighborhood Hits	75	Shared Neighborhood Hits	66
SwissProt Accessions	P51658, O08898	Gene names	Hsd17b2, Edh17b2
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 2 (EC 1.1.1.62) (17-beta-HSD 2) (17- beta-hydroxysteroid dehydrogenase 2).

DHB13_MOUSE
θ value	1.99992e-07 (rank : 20)	NC score	0.574118 (rank : 24)
Query Neighborhood Hits	74	Target Neighborhood Hits	69	Shared Neighborhood Hits	64
SwissProt Accessions	Q8VCR2, Q8CIU2	Gene names	Hsd17b13, Scdr9
Domain Architecture	No domain graphic available
Description	17-beta hydroxysteroid dehydrogenase 13 precursor (EC 1.1.-.-) (Short- chain dehydrogenase/reductase 9) (Alcohol dehydrogenase PAN1B-like).

RDH7_MOUSE
θ value	3.41135e-07 (rank : 21)	NC score	0.523394 (rank : 37)
Query Neighborhood Hits	74	Target Neighborhood Hits	72	Shared Neighborhood Hits	68
SwissProt Accessions	O88451	Gene names	Rdh7, Crad2
Domain Architecture	No domain graphic available
Description	Retinol dehydrogenase 7 (EC 1.1.1.105) (Cis-retinol/androgen dehydrogenase type 2) (CRAD-2) (cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase isozyme 2).

DHB8_HUMAN
θ value	4.45536e-07 (rank : 22)	NC score	0.486767 (rank : 51)
Query Neighborhood Hits	74	Target Neighborhood Hits	71	Shared Neighborhood Hits	67
SwissProt Accessions	Q92506, Q9UIQ1	Gene names	HSD17B8, FABGL, HKE6, RING2
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 8 (EC 1.1.1.62) (17-beta-HSD 8) (17- beta-hydroxysteroid dehydrogenase 8) (Protein Ke6) (Ke-6).

DHRS7_HUMAN
θ value	4.45536e-07 (rank : 23)	NC score	0.617291 (rank : 18)
Query Neighborhood Hits	74	Target Neighborhood Hits	73	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y394, Q9UKU2	Gene names	DHRS7, RETSDR4
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 7 precursor (EC 1.1.-.-) (Retinal short-chain dehydrogenase/reductase 4) (retSDR4).

PECR_HUMAN
θ value	5.81887e-07 (rank : 24)	NC score	0.547936 (rank : 32)
Query Neighborhood Hits	74	Target Neighborhood Hits	77	Shared Neighborhood Hits	70
SwissProt Accessions	Q9BY49, Q6IAK9, Q9NRD4, Q9NY60, Q9P1A4	Gene names	PECR
Domain Architecture	No domain graphic available
Description	Peroxisomal trans-2-enoyl-CoA reductase (EC 1.3.1.38) (TERP) (HPDHase) (pVI-ARL) (2,4-dienoyl-CoA reductase-related protein) (DCR-RP).

DHRS7_MOUSE
θ value	7.59969e-07 (rank : 25)	NC score	0.636095 (rank : 16)
Query Neighborhood Hits	74	Target Neighborhood Hits	75	Shared Neighborhood Hits	70
SwissProt Accessions	Q9CXR1	Gene names	Dhrs7, Retsdr4
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 7 precursor (EC 1.1.-.-) (Retinal short-chain dehydrogenase/reductase 4).

DHB13_HUMAN
θ value	1.69304e-06 (rank : 26)	NC score	0.573087 (rank : 25)
Query Neighborhood Hits	74	Target Neighborhood Hits	70	Shared Neighborhood Hits	63
SwissProt Accessions	Q7Z5P4, Q86W22, Q86W23	Gene names	HSD17B13, SCDR9
Domain Architecture	No domain graphic available
Description	17-beta hydroxysteroid dehydrogenase 13 precursor (EC 1.1.-.-) (Short- chain dehydrogenase/reductase 9).

RDH1_HUMAN
θ value	1.69304e-06 (rank : 27)	NC score	0.516537 (rank : 39)
Query Neighborhood Hits	74	Target Neighborhood Hits	68	Shared Neighborhood Hits	62
SwissProt Accessions	Q92781, Q8TAI2	Gene names	RDH5, RDH1
Domain Architecture
Description	11-cis retinol dehydrogenase (EC 1.1.1.105) (11-cis RDH).

PGDH_MOUSE
θ value	2.88788e-06 (rank : 28)	NC score	0.604897 (rank : 20)
Query Neighborhood Hits	74	Target Neighborhood Hits	73	Shared Neighborhood Hits	68
SwissProt Accessions	Q8VCC1, Q61106	Gene names	Hpgd, Pgdh1
Domain Architecture	No domain graphic available
Description	15-hydroxyprostaglandin dehydrogenase [NAD+] (EC 1.1.1.141) (PGDH) (Prostaglandin dehydrogenase 1).

DHR11_HUMAN
θ value	3.77169e-06 (rank : 29)	NC score	0.579842 (rank : 23)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	69
SwissProt Accessions	Q6UWP2, Q9BUC7, Q9H674	Gene names	ames=UNQ836/PRO1774
Domain Architecture	No domain graphic available
Description	Dehydrogenase/reductase SDR family member 11 precursor (EC 1.-.-.-).

DHI1_HUMAN
θ value	4.92598e-06 (rank : 30)	NC score	0.552718 (rank : 29)
Query Neighborhood Hits	74	Target Neighborhood Hits	72	Shared Neighborhood Hits	67
SwissProt Accessions	P28845	Gene names	HSD11B1, HSD11, HSD11L
Domain Architecture
Description	Corticosteroid 11-beta-dehydrogenase isozyme 1 (EC 1.1.1.146) (11-DH) (11-beta-hydroxysteroid dehydrogenase 1) (11-beta-HSD1).

DECR2_HUMAN
θ value	8.40245e-06 (rank : 31)	NC score	0.487533 (rank : 50)
Query Neighborhood Hits	74	Target Neighborhood Hits	65	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NUI1, Q6ZRS7, Q96ET0	Gene names	DECR2, PDCR
Domain Architecture	No domain graphic available
Description	Peroxisomal 2,4-dienoyl-CoA reductase (EC 1.3.1.34) (2,4-dienoyl-CoA reductase 2) (pDCR).

DHRS1_MOUSE
θ value	8.40245e-06 (rank : 32)	NC score	0.548264 (rank : 31)
Query Neighborhood Hits	74	Target Neighborhood Hits	67	Shared Neighborhood Hits	65
SwissProt Accessions	Q99L04, Q3THW0, Q9D148	Gene names	Dhrs1, D14ertd484e
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-).

BDH2_MOUSE
θ value	1.09739e-05 (rank : 33)	NC score	0.546380 (rank : 33)
Query Neighborhood Hits	74	Target Neighborhood Hits	70	Shared Neighborhood Hits	64
SwissProt Accessions	Q8JZV9	Gene names	Bdh2, Dhrs6
Domain Architecture	No domain graphic available
Description	3-hydroxybutyrate dehydrogenase type 2 (EC 1.1.1.30) (R-beta- hydroxybutyrate dehydrogenase) (Dehydrogenase/reductase SDR family member 6).

DCXR_HUMAN
θ value	1.43324e-05 (rank : 34)	NC score	0.514721 (rank : 41)
Query Neighborhood Hits	74	Target Neighborhood Hits	78	Shared Neighborhood Hits	69
SwissProt Accessions	Q7Z4W1, Q9BTZ3, Q9UHY9	Gene names	DCXR
Domain Architecture	No domain graphic available
Description	L-xylulose reductase (EC 1.1.1.10) (XR) (Dicarbonyl/L-xylulose reductase) (Kidney dicarbonyl reductase) (kiDCR) (Carbonyl reductase II) (Sperm surface protein P34H).

DHRS1_HUMAN
θ value	2.44474e-05 (rank : 35)	NC score	0.528140 (rank : 35)
Query Neighborhood Hits	74	Target Neighborhood Hits	61	Shared Neighborhood Hits	59
SwissProt Accessions	Q96LJ7, Q8NDG3, Q96B59, Q96CQ5	Gene names	DHRS1
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-).

FVT1_HUMAN
θ value	2.44474e-05 (rank : 36)	NC score	0.561979 (rank : 28)
Query Neighborhood Hits	74	Target Neighborhood Hits	71	Shared Neighborhood Hits	66
SwissProt Accessions	Q06136	Gene names	FVT1
Domain Architecture
Description	3-ketodihydrosphingosine reductase precursor (EC 1.1.1.102) (3- dehydrosphinganine reductase) (KDS reductase) (Follicular variant translocation protein 1) (FVT-1).

PECR_MOUSE
θ value	2.44474e-05 (rank : 37)	NC score	0.551378 (rank : 30)
Query Neighborhood Hits	74	Target Neighborhood Hits	73	Shared Neighborhood Hits	69
SwissProt Accessions	Q99MZ7, Q9CX01, Q9JIF4	Gene names	Pecr
Domain Architecture	No domain graphic available
Description	Peroxisomal trans-2-enoyl-CoA reductase (EC 1.3.1.38).

FVT1_MOUSE
θ value	3.19293e-05 (rank : 38)	NC score	0.566371 (rank : 26)
Query Neighborhood Hits	74	Target Neighborhood Hits	68	Shared Neighborhood Hits	65
SwissProt Accessions	Q6GV12	Gene names	Fvt1
Domain Architecture	No domain graphic available
Description	3-ketodihydrosphingosine reductase precursor (EC 1.1.1.102) (3- dehydrosphinganine reductase) (KDS reductase) (Follicular variant translocation protein 1) (FVT-1).

DHB4_HUMAN
θ value	4.1701e-05 (rank : 39)	NC score	0.401429 (rank : 67)
Query Neighborhood Hits	74	Target Neighborhood Hits	83	Shared Neighborhood Hits	63
SwissProt Accessions	P51659	Gene names	HSD17B4, EDH17B4
Domain Architecture
Description	Peroxisomal multifunctional enzyme type 2 (MFE-2) (D-bifunctional protein) (DBP) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-3-hydroxyacyl-CoA dehydratase) (EC 4.2.1.107) (3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase) (3- hydroxyacyl-CoA dehydrogenase) (EC 1.1.1.35).

DHR11_MOUSE
θ value	4.1701e-05 (rank : 40)	NC score	0.563123 (rank : 27)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	69
SwissProt Accessions	Q3U0B3, Q5SXB3, Q8R249	Gene names
Domain Architecture	No domain graphic available
Description	Dehydrogenase/reductase SDR family member 11 precursor (EC 1.-.-.-).

PGDH_HUMAN
θ value	4.1701e-05 (rank : 41)	NC score	0.590601 (rank : 22)
Query Neighborhood Hits	74	Target Neighborhood Hits	73	Shared Neighborhood Hits	68
SwissProt Accessions	P15428	Gene names	HPGD, PGDH1
Domain Architecture
Description	15-hydroxyprostaglandin dehydrogenase [NAD+] (EC 1.1.1.141) (PGDH) (Prostaglandin dehydrogenase 1).

DHRS2_HUMAN
θ value	9.29e-05 (rank : 42)	NC score	0.511111 (rank : 43)
Query Neighborhood Hits	74	Target Neighborhood Hits	72	Shared Neighborhood Hits	70
SwissProt Accessions	Q13268, Q9H2R2	Gene names	DHRS2
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 2 (EC 1.1.-.-) (HEP27 protein) (Protein D).

DHI1_MOUSE
θ value	0.00020696 (rank : 43)	NC score	0.507575 (rank : 44)
Query Neighborhood Hits	74	Target Neighborhood Hits	78	Shared Neighborhood Hits	67
SwissProt Accessions	P50172	Gene names	Hsd11b1, Hsd11
Domain Architecture
Description	Corticosteroid 11-beta-dehydrogenase isozyme 1 (EC 1.1.1.146) (11-DH) (11-beta-hydroxysteroid dehydrogenase 1) (11-beta-HSD1) (11beta- HSD1A).

DCXR_MOUSE
θ value	0.00035302 (rank : 44)	NC score	0.511742 (rank : 42)
Query Neighborhood Hits	74	Target Neighborhood Hits	71	Shared Neighborhood Hits	67
SwissProt Accessions	Q91X52, Q3U5L5, Q9D129, Q9D8W1	Gene names	Dcxr
Domain Architecture	No domain graphic available
Description	L-xylulose reductase (EC 1.1.1.10) (XR) (Dicarbonyl/L-xylulose reductase).

DHRS4_HUMAN
θ value	0.000461057 (rank : 45)	NC score	0.493961 (rank : 49)
Query Neighborhood Hits	74	Target Neighborhood Hits	70	Shared Neighborhood Hits	66
SwissProt Accessions	Q9BTZ2, O95162, Q6UWU3, Q8TD03, Q9H3N5, Q9NV08	Gene names	DHRS4
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (NADPH- dependent carbonyl reductase/NADP-retinol dehydrogenase) (CR) (PHCR) (Peroxisomal short-chain alcohol dehydrogenase) (NADPH-dependent retinol dehydrogenase/reductase) (NDRD) (SCAD-SRL) (humNRDR) (PSCD).

DHB4_MOUSE
θ value	0.000786445 (rank : 46)	NC score	0.385986 (rank : 68)
Query Neighborhood Hits	74	Target Neighborhood Hits	78	Shared Neighborhood Hits	63
SwissProt Accessions	P51660, Q9DBM3	Gene names	Hsd17b4, Edh17b4
Domain Architecture
Description	Peroxisomal multifunctional enzyme type 2 (MFE-2) (D-bifunctional protein) (DBP) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-3-hydroxyacyl-CoA dehydratase) (EC 4.2.1.107) (3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase) (3- hydroxyacyl-CoA dehydrogenase) (EC 1.1.1.35).

DHRS4_MOUSE
θ value	0.000786445 (rank : 47)	NC score	0.477774 (rank : 53)
Query Neighborhood Hits	74	Target Neighborhood Hits	67	Shared Neighborhood Hits	64
SwissProt Accessions	Q99LB2, Q9EQU4	Gene names	Dhrs4, D14Ucla2
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (NADPH- dependent carbonyl reductase/NADP-retinol dehydrogenase) (CR) (PHCR) (Peroxisomal short-chain alcohol dehydrogenase) (NADPH-dependent retinol dehydrogenase/reductase) (NDRD) (mouNRDR).

DHRS3_MOUSE
θ value	0.00175202 (rank : 48)	NC score	0.521293 (rank : 38)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	68
SwissProt Accessions	O88876, Q3UAD1, Q91WR0, Q91XC3, Q922A6	Gene names	Dhrs3, Rsdr1
Domain Architecture
Description	Short-chain dehydrogenase/reductase 3 (EC 1.1.-.-) (Retinal short- chain dehydrogenase/reductase 1) (retSDR1).

DHRS3_HUMAN
θ value	0.00390308 (rank : 49)	NC score	0.515977 (rank : 40)
Query Neighborhood Hits	74	Target Neighborhood Hits	73	Shared Neighborhood Hits	67
SwissProt Accessions	O75911, Q6UY38, Q9BUC8	Gene names	DHRS3
Domain Architecture
Description	Short-chain dehydrogenase/reductase 3 (EC 1.1.-.-) (Retinal short- chain dehydrogenase/reductase 1) (retSDR1) (DD83.1).

DHRS9_HUMAN
θ value	0.00390308 (rank : 50)	NC score	0.498167 (rank : 47)
Query Neighborhood Hits	74	Target Neighborhood Hits	65	Shared Neighborhood Hits	61
SwissProt Accessions	Q9BPW9, Q5RKX1, Q9NRA9, Q9NRB0	Gene names	DHRS9
Domain Architecture	No domain graphic available
Description	Dehydrogenase/reductase SDR family member 9 precursor (EC 1.1.-.-) (3- alpha hydroxysteroid dehydrogenase) (3alpha-HSD) (RDH-E2) (Short-chain dehydrogenase/reductase retSDR8) (NADP-dependent retinol dehydrogenase/reductase) (RDHL).

BDH2_HUMAN
θ value	0.00509761 (rank : 51)	NC score	0.499937 (rank : 46)
Query Neighborhood Hits	74	Target Neighborhood Hits	72	Shared Neighborhood Hits	63
SwissProt Accessions	Q9BUT1, Q503A0, Q6IA46, Q6UWD3, Q9H8S8, Q9NRX8	Gene names	BDH2, DHRS6
Domain Architecture	No domain graphic available
Description	3-hydroxybutyrate dehydrogenase type 2 (EC 1.1.1.30) (R-beta- hydroxybutyrate dehydrogenase) (Dehydrogenase/reductase SDR family member 6) (Oxidoreductase UCPA).

DECR2_MOUSE
θ value	0.00509761 (rank : 52)	NC score	0.439545 (rank : 60)
Query Neighborhood Hits	74	Target Neighborhood Hits	63	Shared Neighborhood Hits	60
SwissProt Accessions	Q9WV68	Gene names	Decr2, Pdcr
Domain Architecture	No domain graphic available
Description	Peroxisomal 2,4-dienoyl-CoA reductase (EC 1.3.1.34) (2,4-dienoyl-CoA reductase 2).

DHRS9_MOUSE
θ value	0.00509761 (rank : 53)	NC score	0.502909 (rank : 45)
Query Neighborhood Hits	74	Target Neighborhood Hits	70	Shared Neighborhood Hits	64
SwissProt Accessions	Q58NB6, Q8BGC7	Gene names	Dhrs9
Domain Architecture	No domain graphic available
Description	Dehydrogenase/reductase SDR family member 9 precursor (EC 1.1.-.-) (3- alpha hydroxysteroid dehydrogenase) (3alpha-HSD) (Short-chain dehydrogenase/reductase retSDR8).

DHR10_HUMAN
θ value	0.00665767 (rank : 54)	NC score	0.541162 (rank : 34)
Query Neighborhood Hits	74	Target Neighborhood Hits	71	Shared Neighborhood Hits	67
SwissProt Accessions	Q9BPX1, Q9UKU3	Gene names	DHRS10, SDR3
Domain Architecture	No domain graphic available
Description	Dehydrogenase/reductase SDR family member 10 (EC 1.1.-.-) (Retinal short-chain dehydrogenase/reductase retSDR3).

DHB2_HUMAN
θ value	0.0113563 (rank : 55)	NC score	0.440765 (rank : 59)
Query Neighborhood Hits	74	Target Neighborhood Hits	72	Shared Neighborhood Hits	68
SwissProt Accessions	P37059	Gene names	HSD17B2, EDH17B2
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 2 (EC 1.1.1.62) (17-beta-HSD 2) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (20 alpha- hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH).

DHB3_HUMAN
θ value	0.0193708 (rank : 56)	NC score	0.497854 (rank : 48)
Query Neighborhood Hits	74	Target Neighborhood Hits	69	Shared Neighborhood Hits	65
SwissProt Accessions	P37058	Gene names	HSD17B3, EDH17B3
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 3 (EC 1.1.1.62) (17-beta-HSD 3) (Testicular 17-beta-hydroxysteroid dehydrogenase).

HCD2_MOUSE
θ value	0.0252991 (rank : 57)	NC score	0.434299 (rank : 61)
Query Neighborhood Hits	74	Target Neighborhood Hits	65	Shared Neighborhood Hits	61
SwissProt Accessions	O08756	Gene names	Hadh2, Erab, Hsd17b10
Domain Architecture
Description	3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (3-hydroxyacyl- CoA dehydrogenase type II) (Type II HADH) (3-hydroxy-2-methylbutyryl- CoA dehydrogenase) (EC 1.1.1.178) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein).

DHB12_HUMAN
θ value	0.0431538 (rank : 58)	NC score	0.462546 (rank : 54)
Query Neighborhood Hits	74	Target Neighborhood Hits	69	Shared Neighborhood Hits	67
SwissProt Accessions	Q53GQ0, Q96JU2, Q9Y6G8	Gene names	HSD17B12
Domain Architecture	No domain graphic available
Description	Estradiol 17-beta-dehydrogenase 12 (EC 1.1.1.62) (17-beta-HSD 12) (17- beta-hydroxysteroid dehydrogenase 12) (3-ketoacyl-CoA reductase) (EC 1.3.1.-) (KAR).

DECR_MOUSE
θ value	0.0563607 (rank : 59)	NC score	0.442094 (rank : 58)
Query Neighborhood Hits	74	Target Neighborhood Hits	66	Shared Neighborhood Hits	63
SwissProt Accessions	Q9CQ62, Q9DCI7	Gene names	Decr1
Domain Architecture	No domain graphic available
Description	2,4-dienoyl-CoA reductase, mitochondrial precursor (EC 1.3.1.34) (2,4- dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH]).

DHB1_MOUSE
θ value	0.0563607 (rank : 60)	NC score	0.427964 (rank : 63)
Query Neighborhood Hits	74	Target Neighborhood Hits	68	Shared Neighborhood Hits	62
SwissProt Accessions	P51656	Gene names	Hsd17b1, Edh17b1
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 1 (EC 1.1.1.62) (17-beta- hydroxysteroid dehydrogenase type 1) (17-beta-HSD 1).

DHI2_MOUSE
θ value	0.0961366 (rank : 61)	NC score	0.410452 (rank : 66)
Query Neighborhood Hits	74	Target Neighborhood Hits	65	Shared Neighborhood Hits	60
SwissProt Accessions	P51661, Q91WK3	Gene names	Hsd11b2, Hsd11k
Domain Architecture
Description	Corticosteroid 11-beta-dehydrogenase isozyme 2 (EC 1.1.1.-) (11-DH2) (11-beta-hydroxysteroid dehydrogenase type 2) (11-beta-HSD2) (NAD- dependent 11-beta-hydroxysteroid dehydrogenase).

SPRE_MOUSE
θ value	0.125558 (rank : 62)	NC score	0.212188 (rank : 72)
Query Neighborhood Hits	74	Target Neighborhood Hits	47	Shared Neighborhood Hits	40
SwissProt Accessions	Q64105, Q63996	Gene names	Spr
Domain Architecture
Description	Sepiapterin reductase (EC 1.1.1.153) (SPR).

DECR_HUMAN
θ value	0.21417 (rank : 63)	NC score	0.427409 (rank : 64)
Query Neighborhood Hits	74	Target Neighborhood Hits	66	Shared Neighborhood Hits	62
SwissProt Accessions	Q16698, Q93085	Gene names	DECR1, DECR
Domain Architecture
Description	2,4-dienoyl-CoA reductase, mitochondrial precursor (EC 1.3.1.34) (2,4- dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH]).

BDH_MOUSE
θ value	0.279714 (rank : 64)	NC score	0.443260 (rank : 57)
Query Neighborhood Hits	74	Target Neighborhood Hits	70	Shared Neighborhood Hits	65
SwissProt Accessions	Q80XN0, Q3UJS9, Q8BK53, Q8R0C8	Gene names	Bdh1, Bdh
Domain Architecture	No domain graphic available
Description	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor (EC 1.1.1.30) (BDH) (3-hydroxybutyrate dehydrogenase).

DHB12_MOUSE
θ value	0.813845 (rank : 65)	NC score	0.447234 (rank : 55)
Query Neighborhood Hits	74	Target Neighborhood Hits	70	Shared Neighborhood Hits	67
SwissProt Accessions	O70503, Q3TID1, Q3U7V9, Q542N3, Q8CI39	Gene names	Hsd17b12, Kik1
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 12 (EC 1.1.1.62) (17-beta-HSD 12) (17- beta-hydroxysteroid dehydrogenase 12) (3-ketoacyl-CoA reductase) (EC 1.3.1.-) (KAR) (KIK-I).

DHB3_MOUSE
θ value	2.36792 (rank : 66)	NC score	0.446416 (rank : 56)
Query Neighborhood Hits	74	Target Neighborhood Hits	67	Shared Neighborhood Hits	63
SwissProt Accessions	P70385	Gene names	Hsd17b3, Edh17b3
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 3 (EC 1.1.1.62) (17-beta-HSD 3) (Testicular 17-beta-hydroxysteroid dehydrogenase).

SPRE_HUMAN
θ value	3.0926 (rank : 67)	NC score	0.142376 (rank : 73)
Query Neighborhood Hits	74	Target Neighborhood Hits	32	Shared Neighborhood Hits	29
SwissProt Accessions	P35270	Gene names	SPR
Domain Architecture
Description	Sepiapterin reductase (EC 1.1.1.153) (SPR).

DHB1_HUMAN
θ value	5.27518 (rank : 68)	NC score	0.429081 (rank : 62)
Query Neighborhood Hits	74	Target Neighborhood Hits	67	Shared Neighborhood Hits	65
SwissProt Accessions	P14061	Gene names	HSD17B1, E17KSR, EDH17B1, EDHB17
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 1 (EC 1.1.1.62) (17-beta- hydroxysteroid dehydrogenase type 1) (17-beta-HSD 1) (Placental 17- beta-hydroxysteroid dehydrogenase) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH).

HCD2_HUMAN
θ value	5.27518 (rank : 69)	NC score	0.413507 (rank : 65)
Query Neighborhood Hits	74	Target Neighborhood Hits	73	Shared Neighborhood Hits	68
SwissProt Accessions	Q99714, Q8TCV9, Q96HD5	Gene names	HADH2, ERAB, HSD17B10, SCHAD, XH98G2
Domain Architecture
Description	3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (3-hydroxyacyl- CoA dehydrogenase type II) (Type II HADH) (3-hydroxy-2-methylbutyryl- CoA dehydrogenase) (EC 1.1.1.178) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Short-chain type dehydrogenase/reductase XH98G2).

RIP_MOUSE
θ value	5.27518 (rank : 70)	NC score	0.014920 (rank : 77)
Query Neighborhood Hits	74	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CWY9	Gene names	Rpain, Rip
Domain Architecture	No domain graphic available
Description	RPA-interacting protein.

BDH_HUMAN
θ value	8.99809 (rank : 71)	NC score	0.383812 (rank : 69)
Query Neighborhood Hits	74	Target Neighborhood Hits	65	Shared Neighborhood Hits	63
SwissProt Accessions	Q02338, Q96ET1, Q9BRZ4	Gene names	BDH1, BDH
Domain Architecture
Description	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor (EC 1.1.1.30) (BDH) (3-hydroxybutyrate dehydrogenase).

DHB8_MOUSE
θ value	8.99809 (rank : 72)	NC score	0.321400 (rank : 71)
Query Neighborhood Hits	74	Target Neighborhood Hits	56	Shared Neighborhood Hits	53
SwissProt Accessions	P50171, Q60958, Q60959, Q9Z1W2	Gene names	Hsd17b8, H2-Ke6, Hke6
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 8 (EC 1.1.1.62) (17-beta-HSD 8) (17- beta-hydroxysteroid dehydrogenase 8) (Protein Ke6) (Ke-6).

MECR_HUMAN
θ value	8.99809 (rank : 73)	NC score	0.009222 (rank : 78)
Query Neighborhood Hits	74	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BV79, Q5SYU0, Q5SYU1, Q5SYU2, Q6IBU9, Q9Y373	Gene names	MECR, NBRF1
Domain Architecture	No domain graphic available
Description	Trans-2-enoyl-CoA reductase, mitochondrial precursor (EC 1.3.1.38) (HsNrbf-1) (NRBF-1).

MYH11_HUMAN
θ value	8.99809 (rank : 74)	NC score	-0.004712 (rank : 79)
Query Neighborhood Hits	74	Target Neighborhood Hits	1806	Shared Neighborhood Hits	2
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

CBR2_MOUSE
θ value	θ > 10 (rank : 75)	NC score	0.525273 (rank : 36)
Query Neighborhood Hits	74	Target Neighborhood Hits	75	Shared Neighborhood Hits	68
SwissProt Accessions	P08074	Gene names	Cbr2
Domain Architecture
Description	Lung carbonyl reductase [NADPH] (EC 1.1.1.184) (NADPH-dependent carbonyl reductase) (LCR) (Adipocyte P27 protein) (AP27).

DHI2_HUMAN
θ value	θ > 10 (rank : 76)	NC score	0.327487 (rank : 70)
Query Neighborhood Hits	74	Target Neighborhood Hits	62	Shared Neighborhood Hits	59
SwissProt Accessions	P80365, Q13194, Q8N439, Q96QN8, Q9UC50, Q9UC51	Gene names	HSD11B2, HSD11K
Domain Architecture
Description	Corticosteroid 11-beta-dehydrogenase isozyme 2 (EC 1.1.1.-) (11-DH2) (11-beta-hydroxysteroid dehydrogenase type 2) (11-beta-HSD2) (NAD- dependent 11-beta-hydroxysteroid dehydrogenase).

SAV1_HUMAN
θ value	θ > 10 (rank : 77)	NC score	0.051731 (rank : 75)
Query Neighborhood Hits	74	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SAV1_MOUSE
θ value	θ > 10 (rank : 78)	NC score	0.051308 (rank : 76)
Query Neighborhood Hits	74	Target Neighborhood Hits	48	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

YAP1_MOUSE
θ value	θ > 10 (rank : 79)	NC score	0.052212 (rank : 74)
Query Neighborhood Hits	74	Target Neighborhood Hits	96	Shared Neighborhood Hits	2
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

Hits sorted by NC score

RDH14_MOUSE
NC score	0.999962 (rank : 1)	θ value	1.46188e-167 (rank : 1)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	74
SwissProt Accessions	Q9ERI6	Gene names	Rdh14
Domain Architecture
Description	Retinol dehydrogenase 14 (EC 1.1.1.-) (Alcohol dehydrogenase PAN2).

RDH14_HUMAN
NC score	0.994108 (rank : 2)	θ value	1.51984e-148 (rank : 2)
Query Neighborhood Hits	74	Target Neighborhood Hits	76	Shared Neighborhood Hits	70
SwissProt Accessions	Q9HBH5	Gene names	RDH14, PAN2
Domain Architecture
Description	Retinol dehydrogenase 14 (EC 1.1.1.-) (Alcohol dehydrogenase PAN2).

RDH12_MOUSE
NC score	0.962425 (rank : 3)	θ value	4.68348e-65 (rank : 5)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	67
SwissProt Accessions	Q8BYK4, Q91WA5, Q9D1Y4	Gene names	Rdh12
Domain Architecture
Description	Retinol dehydrogenase 12 (EC 1.1.1.-).

RDH13_HUMAN
NC score	0.959609 (rank : 4)	θ value	1.04338e-64 (rank : 6)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	68
SwissProt Accessions	Q8NBN7, Q6UX79, Q96G88	Gene names	RDH13
Domain Architecture
Description	Retinol dehydrogenase 13 (EC 1.1.1.-).

RDH12_HUMAN
NC score	0.958852 (rank : 5)	θ value	1.45591e-66 (rank : 4)
Query Neighborhood Hits	74	Target Neighborhood Hits	72	Shared Neighborhood Hits	67
SwissProt Accessions	Q96NR8, Q8TAW6	Gene names	RDH12
Domain Architecture
Description	Retinol dehydrogenase 12 (EC 1.1.1.-) (All-trans and 9-cis retinol dehydrogenase).

RDH11_MOUSE
NC score	0.957580 (rank : 6)	θ value	1.45929e-58 (rank : 8)
Query Neighborhood Hits	74	Target Neighborhood Hits	69	Shared Neighborhood Hits	68
SwissProt Accessions	Q9QYF1, Q3UXM9, Q9D0U5	Gene names	Rdh11, Arsdr1, Mdt1, Psdr1
Domain Architecture
Description	Retinol dehydrogenase 11 (EC 1.1.1.-) (Retinal reductase 1) (RalR1) (Prostate short-chain dehydrogenase/reductase 1) (Androgen-regulated short-chain dehydrogenase/reductase 1) (Short-chain aldehyde dehydrogenase) (SCALD) (Cell line MC/9.IL4-derived protein 1) (M42C60).

RDH13_MOUSE
NC score	0.955458 (rank : 7)	θ value	4.52582e-68 (rank : 3)
Query Neighborhood Hits	74	Target Neighborhood Hits	75	Shared Neighborhood Hits	68
SwissProt Accessions	Q8CEE7, Q8CC07	Gene names	Rdh13
Domain Architecture
Description	Retinol dehydrogenase 13 (EC 1.1.1.-).

RDH11_HUMAN
NC score	0.953255 (rank : 8)	θ value	1.31987e-59 (rank : 7)
Query Neighborhood Hits	74	Target Neighborhood Hits	71	Shared Neighborhood Hits	67
SwissProt Accessions	Q8TC12, Q9NRW0, Q9Y391	Gene names	RDH11, ARSDR1, PSDR1
Domain Architecture
Description	Retinol dehydrogenase 11 (EC 1.1.1.-) (Retinal reductase 1) (RalR1) (Prostate short-chain dehydrogenase/reductase 1) (Androgen-regulated short-chain dehydrogenase/reductase 1) (HCV core-binding protein HCBP12).

DHRSX_HUMAN
NC score	0.942227 (rank : 9)	θ value	1.32601e-43 (rank : 11)
Query Neighborhood Hits	74	Target Neighborhood Hits	71	Shared Neighborhood Hits	64
SwissProt Accessions	Q8N5I4, Q6UWC7, Q8WUS4, Q96GR8, Q9NTF6	Gene names	DHRSX, CXorf11, DHRS5X
Domain Architecture
Description	Dehydrogenase/reductase SDR family member on chromosome X precursor (EC 1.1.-.-) (DHRSXY).

WWOX_MOUSE
NC score	0.816044 (rank : 10)	θ value	5.7518e-47 (rank : 10)
Query Neighborhood Hits	74	Target Neighborhood Hits	118	Shared Neighborhood Hits	64
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

WWOX_HUMAN
NC score	0.811449 (rank : 11)	θ value	3.04986e-48 (rank : 9)
Query Neighborhood Hits	74	Target Neighborhood Hits	115	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

DHB7_HUMAN
NC score	0.689213 (rank : 12)	θ value	1.42992e-13 (rank : 12)
Query Neighborhood Hits	74	Target Neighborhood Hits	49	Shared Neighborhood Hits	45
SwissProt Accessions	P56937, Q7Z4V9, Q8WWS2, Q9UF00	Gene names	HSD17B7
Domain Architecture
Description	3-keto-steroid reductase (EC 1.1.1.270) (Estradiol 17-beta- dehydrogenase 7) (EC 1.1.1.62) (17-beta-HSD 7) (17-beta-hydroxysteroid dehydrogenase 7).

DHB7_MOUSE
NC score	0.673420 (rank : 13)	θ value	1.86753e-13 (rank : 13)
Query Neighborhood Hits	74	Target Neighborhood Hits	42	Shared Neighborhood Hits	41
SwissProt Accessions	O88736, Q8K5C9, Q921L1	Gene names	Hsd17b7
Domain Architecture
Description	3-keto-steroid reductase (EC 1.1.1.270) (Estradiol 17-beta- dehydrogenase 7) (EC 1.1.1.62) (17-beta-HSD 7) (17-beta-hydroxysteroid dehydrogenase 7).

DHC3_HUMAN
NC score	0.661881 (rank : 14)	θ value	8.67504e-11 (rank : 16)
Query Neighborhood Hits	74	Target Neighborhood Hits	67	Shared Neighborhood Hits	63
SwissProt Accessions	O75828	Gene names	CBR3
Domain Architecture
Description	Carbonyl reductase [NADPH] 3 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 3).

DHCA_HUMAN
NC score	0.650950 (rank : 15)	θ value	6.00763e-12 (rank : 14)
Query Neighborhood Hits	74	Target Neighborhood Hits	63	Shared Neighborhood Hits	60
SwissProt Accessions	P16152	Gene names	CBR1, CBR, CRN
Domain Architecture
Description	Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 1) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) (Prostaglandin 9-ketoreductase) (15-hydroxyprostaglandin dehydrogenase [NADP+]) (EC 1.1.1.197).

DHRS7_MOUSE
NC score	0.636095 (rank : 16)	θ value	7.59969e-07 (rank : 25)
Query Neighborhood Hits	74	Target Neighborhood Hits	75	Shared Neighborhood Hits	70
SwissProt Accessions	Q9CXR1	Gene names	Dhrs7, Retsdr4
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 7 precursor (EC 1.1.-.-) (Retinal short-chain dehydrogenase/reductase 4).

DHCA_MOUSE
NC score	0.628519 (rank : 17)	θ value	7.84624e-12 (rank : 15)
Query Neighborhood Hits	74	Target Neighborhood Hits	61	Shared Neighborhood Hits	57
SwissProt Accessions	P48758	Gene names	Cbr1, Cbr
Domain Architecture
Description	Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (NADPH-dependent carbonyl reductase 1).

DHRS7_HUMAN
NC score	0.617291 (rank : 18)	θ value	4.45536e-07 (rank : 23)
Query Neighborhood Hits	74	Target Neighborhood Hits	73	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y394, Q9UKU2	Gene names	DHRS7, RETSDR4
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 7 precursor (EC 1.1.-.-) (Retinal short-chain dehydrogenase/reductase 4) (retSDR4).

DHRS8_HUMAN
NC score	0.607699 (rank : 19)	θ value	2.36244e-08 (rank : 18)
Query Neighborhood Hits	74	Target Neighborhood Hits	68	Shared Neighborhood Hits	66
SwissProt Accessions	Q8NBQ5, Q96HF6, Q9UKU4	Gene names	DHRS8, HSD17B11, PAN1B
Domain Architecture	No domain graphic available
Description	Dehydrogenase/reductase SDR family member 8 precursor (EC 1.1.1.-) (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17-beta- HSD XI) (17betaHSDXI) (17bHSD11) (17betaHSD11) (Retinal short-chain dehydrogenase/reductase 2) (retSDR2) (Cutaneous T-cell lymphoma- associated antigen HD-CL-03) (CTCL tumor antigen HD-CL-03).

PGDH_MOUSE
NC score	0.604897 (rank : 20)	θ value	2.88788e-06 (rank : 28)
Query Neighborhood Hits	74	Target Neighborhood Hits	73	Shared Neighborhood Hits	68
SwissProt Accessions	Q8VCC1, Q61106	Gene names	Hpgd, Pgdh1
Domain Architecture	No domain graphic available
Description	15-hydroxyprostaglandin dehydrogenase [NAD+] (EC 1.1.1.141) (PGDH) (Prostaglandin dehydrogenase 1).

DHRS8_MOUSE
NC score	0.603982 (rank : 21)	θ value	1.38499e-08 (rank : 17)
Query Neighborhood Hits	74	Target Neighborhood Hits	72	Shared Neighborhood Hits	67
SwissProt Accessions	Q9EQ06, Q3U2P6, Q8BR33, Q8C7S0	Gene names	Dhrs8, Hsd17b11, Pan1b
Domain Architecture	No domain graphic available
Description	Dehydrogenase/reductase SDR family member 8 precursor (EC 1.1.1.-) (17-beta-hydroxysteroid dehydrogenase 11) (17-beta-HSD 11) (17-beta- HSD XI) (17betaHSDXI) (17bHSD11) (17betaHSD11).

PGDH_HUMAN
NC score	0.590601 (rank : 22)	θ value	4.1701e-05 (rank : 41)
Query Neighborhood Hits	74	Target Neighborhood Hits	73	Shared Neighborhood Hits	68
SwissProt Accessions	P15428	Gene names	HPGD, PGDH1
Domain Architecture
Description	15-hydroxyprostaglandin dehydrogenase [NAD+] (EC 1.1.1.141) (PGDH) (Prostaglandin dehydrogenase 1).

DHR11_HUMAN
NC score	0.579842 (rank : 23)	θ value	3.77169e-06 (rank : 29)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	69
SwissProt Accessions	Q6UWP2, Q9BUC7, Q9H674	Gene names	ames=UNQ836/PRO1774
Domain Architecture	No domain graphic available
Description	Dehydrogenase/reductase SDR family member 11 precursor (EC 1.-.-.-).

DHB13_MOUSE
NC score	0.574118 (rank : 24)	θ value	1.99992e-07 (rank : 20)
Query Neighborhood Hits	74	Target Neighborhood Hits	69	Shared Neighborhood Hits	64
SwissProt Accessions	Q8VCR2, Q8CIU2	Gene names	Hsd17b13, Scdr9
Domain Architecture	No domain graphic available
Description	17-beta hydroxysteroid dehydrogenase 13 precursor (EC 1.1.-.-) (Short- chain dehydrogenase/reductase 9) (Alcohol dehydrogenase PAN1B-like).

DHB13_HUMAN
NC score	0.573087 (rank : 25)	θ value	1.69304e-06 (rank : 26)
Query Neighborhood Hits	74	Target Neighborhood Hits	70	Shared Neighborhood Hits	63
SwissProt Accessions	Q7Z5P4, Q86W22, Q86W23	Gene names	HSD17B13, SCDR9
Domain Architecture	No domain graphic available
Description	17-beta hydroxysteroid dehydrogenase 13 precursor (EC 1.1.-.-) (Short- chain dehydrogenase/reductase 9).

FVT1_MOUSE
NC score	0.566371 (rank : 26)	θ value	3.19293e-05 (rank : 38)
Query Neighborhood Hits	74	Target Neighborhood Hits	68	Shared Neighborhood Hits	65
SwissProt Accessions	Q6GV12	Gene names	Fvt1
Domain Architecture	No domain graphic available
Description	3-ketodihydrosphingosine reductase precursor (EC 1.1.1.102) (3- dehydrosphinganine reductase) (KDS reductase) (Follicular variant translocation protein 1) (FVT-1).

DHR11_MOUSE
NC score	0.563123 (rank : 27)	θ value	4.1701e-05 (rank : 40)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	69
SwissProt Accessions	Q3U0B3, Q5SXB3, Q8R249	Gene names
Domain Architecture	No domain graphic available
Description	Dehydrogenase/reductase SDR family member 11 precursor (EC 1.-.-.-).

FVT1_HUMAN
NC score	0.561979 (rank : 28)	θ value	2.44474e-05 (rank : 36)
Query Neighborhood Hits	74	Target Neighborhood Hits	71	Shared Neighborhood Hits	66
SwissProt Accessions	Q06136	Gene names	FVT1
Domain Architecture
Description	3-ketodihydrosphingosine reductase precursor (EC 1.1.1.102) (3- dehydrosphinganine reductase) (KDS reductase) (Follicular variant translocation protein 1) (FVT-1).

DHI1_HUMAN
NC score	0.552718 (rank : 29)	θ value	4.92598e-06 (rank : 30)
Query Neighborhood Hits	74	Target Neighborhood Hits	72	Shared Neighborhood Hits	67
SwissProt Accessions	P28845	Gene names	HSD11B1, HSD11, HSD11L
Domain Architecture
Description	Corticosteroid 11-beta-dehydrogenase isozyme 1 (EC 1.1.1.146) (11-DH) (11-beta-hydroxysteroid dehydrogenase 1) (11-beta-HSD1).

PECR_MOUSE
NC score	0.551378 (rank : 30)	θ value	2.44474e-05 (rank : 37)
Query Neighborhood Hits	74	Target Neighborhood Hits	73	Shared Neighborhood Hits	69
SwissProt Accessions	Q99MZ7, Q9CX01, Q9JIF4	Gene names	Pecr
Domain Architecture	No domain graphic available
Description	Peroxisomal trans-2-enoyl-CoA reductase (EC 1.3.1.38).

DHRS1_MOUSE
NC score	0.548264 (rank : 31)	θ value	8.40245e-06 (rank : 32)
Query Neighborhood Hits	74	Target Neighborhood Hits	67	Shared Neighborhood Hits	65
SwissProt Accessions	Q99L04, Q3THW0, Q9D148	Gene names	Dhrs1, D14ertd484e
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-).

PECR_HUMAN
NC score	0.547936 (rank : 32)	θ value	5.81887e-07 (rank : 24)
Query Neighborhood Hits	74	Target Neighborhood Hits	77	Shared Neighborhood Hits	70
SwissProt Accessions	Q9BY49, Q6IAK9, Q9NRD4, Q9NY60, Q9P1A4	Gene names	PECR
Domain Architecture	No domain graphic available
Description	Peroxisomal trans-2-enoyl-CoA reductase (EC 1.3.1.38) (TERP) (HPDHase) (pVI-ARL) (2,4-dienoyl-CoA reductase-related protein) (DCR-RP).

BDH2_MOUSE
NC score	0.546380 (rank : 33)	θ value	1.09739e-05 (rank : 33)
Query Neighborhood Hits	74	Target Neighborhood Hits	70	Shared Neighborhood Hits	64
SwissProt Accessions	Q8JZV9	Gene names	Bdh2, Dhrs6
Domain Architecture	No domain graphic available
Description	3-hydroxybutyrate dehydrogenase type 2 (EC 1.1.1.30) (R-beta- hydroxybutyrate dehydrogenase) (Dehydrogenase/reductase SDR family member 6).

DHR10_HUMAN
NC score	0.541162 (rank : 34)	θ value	0.00665767 (rank : 54)
Query Neighborhood Hits	74	Target Neighborhood Hits	71	Shared Neighborhood Hits	67
SwissProt Accessions	Q9BPX1, Q9UKU3	Gene names	DHRS10, SDR3
Domain Architecture	No domain graphic available
Description	Dehydrogenase/reductase SDR family member 10 (EC 1.1.-.-) (Retinal short-chain dehydrogenase/reductase retSDR3).

DHRS1_HUMAN
NC score	0.528140 (rank : 35)	θ value	2.44474e-05 (rank : 35)
Query Neighborhood Hits	74	Target Neighborhood Hits	61	Shared Neighborhood Hits	59
SwissProt Accessions	Q96LJ7, Q8NDG3, Q96B59, Q96CQ5	Gene names	DHRS1
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 1 (EC 1.1.-.-).

CBR2_MOUSE
NC score	0.525273 (rank : 36)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	74	Target Neighborhood Hits	75	Shared Neighborhood Hits	68
SwissProt Accessions	P08074	Gene names	Cbr2
Domain Architecture
Description	Lung carbonyl reductase [NADPH] (EC 1.1.1.184) (NADPH-dependent carbonyl reductase) (LCR) (Adipocyte P27 protein) (AP27).

RDH7_MOUSE
NC score	0.523394 (rank : 37)	θ value	3.41135e-07 (rank : 21)
Query Neighborhood Hits	74	Target Neighborhood Hits	72	Shared Neighborhood Hits	68
SwissProt Accessions	O88451	Gene names	Rdh7, Crad2
Domain Architecture	No domain graphic available
Description	Retinol dehydrogenase 7 (EC 1.1.1.105) (Cis-retinol/androgen dehydrogenase type 2) (CRAD-2) (cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase isozyme 2).

DHRS3_MOUSE
NC score	0.521293 (rank : 38)	θ value	0.00175202 (rank : 48)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	68
SwissProt Accessions	O88876, Q3UAD1, Q91WR0, Q91XC3, Q922A6	Gene names	Dhrs3, Rsdr1
Domain Architecture
Description	Short-chain dehydrogenase/reductase 3 (EC 1.1.-.-) (Retinal short- chain dehydrogenase/reductase 1) (retSDR1).

RDH1_HUMAN
NC score	0.516537 (rank : 39)	θ value	1.69304e-06 (rank : 27)
Query Neighborhood Hits	74	Target Neighborhood Hits	68	Shared Neighborhood Hits	62
SwissProt Accessions	Q92781, Q8TAI2	Gene names	RDH5, RDH1
Domain Architecture
Description	11-cis retinol dehydrogenase (EC 1.1.1.105) (11-cis RDH).

DHRS3_HUMAN
NC score	0.515977 (rank : 40)	θ value	0.00390308 (rank : 49)
Query Neighborhood Hits	74	Target Neighborhood Hits	73	Shared Neighborhood Hits	67
SwissProt Accessions	O75911, Q6UY38, Q9BUC8	Gene names	DHRS3
Domain Architecture
Description	Short-chain dehydrogenase/reductase 3 (EC 1.1.-.-) (Retinal short- chain dehydrogenase/reductase 1) (retSDR1) (DD83.1).

DCXR_HUMAN
NC score	0.514721 (rank : 41)	θ value	1.43324e-05 (rank : 34)
Query Neighborhood Hits	74	Target Neighborhood Hits	78	Shared Neighborhood Hits	69
SwissProt Accessions	Q7Z4W1, Q9BTZ3, Q9UHY9	Gene names	DCXR
Domain Architecture	No domain graphic available
Description	L-xylulose reductase (EC 1.1.1.10) (XR) (Dicarbonyl/L-xylulose reductase) (Kidney dicarbonyl reductase) (kiDCR) (Carbonyl reductase II) (Sperm surface protein P34H).

DCXR_MOUSE
NC score	0.511742 (rank : 42)	θ value	0.00035302 (rank : 44)
Query Neighborhood Hits	74	Target Neighborhood Hits	71	Shared Neighborhood Hits	67
SwissProt Accessions	Q91X52, Q3U5L5, Q9D129, Q9D8W1	Gene names	Dcxr
Domain Architecture	No domain graphic available
Description	L-xylulose reductase (EC 1.1.1.10) (XR) (Dicarbonyl/L-xylulose reductase).

DHRS2_HUMAN
NC score	0.511111 (rank : 43)	θ value	9.29e-05 (rank : 42)
Query Neighborhood Hits	74	Target Neighborhood Hits	72	Shared Neighborhood Hits	70
SwissProt Accessions	Q13268, Q9H2R2	Gene names	DHRS2
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 2 (EC 1.1.-.-) (HEP27 protein) (Protein D).

DHI1_MOUSE
NC score	0.507575 (rank : 44)	θ value	0.00020696 (rank : 43)
Query Neighborhood Hits	74	Target Neighborhood Hits	78	Shared Neighborhood Hits	67
SwissProt Accessions	P50172	Gene names	Hsd11b1, Hsd11
Domain Architecture
Description	Corticosteroid 11-beta-dehydrogenase isozyme 1 (EC 1.1.1.146) (11-DH) (11-beta-hydroxysteroid dehydrogenase 1) (11-beta-HSD1) (11beta- HSD1A).

DHRS9_MOUSE
NC score	0.502909 (rank : 45)	θ value	0.00509761 (rank : 53)
Query Neighborhood Hits	74	Target Neighborhood Hits	70	Shared Neighborhood Hits	64
SwissProt Accessions	Q58NB6, Q8BGC7	Gene names	Dhrs9
Domain Architecture	No domain graphic available
Description	Dehydrogenase/reductase SDR family member 9 precursor (EC 1.1.-.-) (3- alpha hydroxysteroid dehydrogenase) (3alpha-HSD) (Short-chain dehydrogenase/reductase retSDR8).

BDH2_HUMAN
NC score	0.499937 (rank : 46)	θ value	0.00509761 (rank : 51)
Query Neighborhood Hits	74	Target Neighborhood Hits	72	Shared Neighborhood Hits	63
SwissProt Accessions	Q9BUT1, Q503A0, Q6IA46, Q6UWD3, Q9H8S8, Q9NRX8	Gene names	BDH2, DHRS6
Domain Architecture	No domain graphic available
Description	3-hydroxybutyrate dehydrogenase type 2 (EC 1.1.1.30) (R-beta- hydroxybutyrate dehydrogenase) (Dehydrogenase/reductase SDR family member 6) (Oxidoreductase UCPA).

DHRS9_HUMAN
NC score	0.498167 (rank : 47)	θ value	0.00390308 (rank : 50)
Query Neighborhood Hits	74	Target Neighborhood Hits	65	Shared Neighborhood Hits	61
SwissProt Accessions	Q9BPW9, Q5RKX1, Q9NRA9, Q9NRB0	Gene names	DHRS9
Domain Architecture	No domain graphic available
Description	Dehydrogenase/reductase SDR family member 9 precursor (EC 1.1.-.-) (3- alpha hydroxysteroid dehydrogenase) (3alpha-HSD) (RDH-E2) (Short-chain dehydrogenase/reductase retSDR8) (NADP-dependent retinol dehydrogenase/reductase) (RDHL).

DHB3_HUMAN
NC score	0.497854 (rank : 48)	θ value	0.0193708 (rank : 56)
Query Neighborhood Hits	74	Target Neighborhood Hits	69	Shared Neighborhood Hits	65
SwissProt Accessions	P37058	Gene names	HSD17B3, EDH17B3
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 3 (EC 1.1.1.62) (17-beta-HSD 3) (Testicular 17-beta-hydroxysteroid dehydrogenase).

DHRS4_HUMAN
NC score	0.493961 (rank : 49)	θ value	0.000461057 (rank : 45)
Query Neighborhood Hits	74	Target Neighborhood Hits	70	Shared Neighborhood Hits	66
SwissProt Accessions	Q9BTZ2, O95162, Q6UWU3, Q8TD03, Q9H3N5, Q9NV08	Gene names	DHRS4
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (NADPH- dependent carbonyl reductase/NADP-retinol dehydrogenase) (CR) (PHCR) (Peroxisomal short-chain alcohol dehydrogenase) (NADPH-dependent retinol dehydrogenase/reductase) (NDRD) (SCAD-SRL) (humNRDR) (PSCD).

DECR2_HUMAN
NC score	0.487533 (rank : 50)	θ value	8.40245e-06 (rank : 31)
Query Neighborhood Hits	74	Target Neighborhood Hits	65	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NUI1, Q6ZRS7, Q96ET0	Gene names	DECR2, PDCR
Domain Architecture	No domain graphic available
Description	Peroxisomal 2,4-dienoyl-CoA reductase (EC 1.3.1.34) (2,4-dienoyl-CoA reductase 2) (pDCR).

DHB8_HUMAN
NC score	0.486767 (rank : 51)	θ value	4.45536e-07 (rank : 22)
Query Neighborhood Hits	74	Target Neighborhood Hits	71	Shared Neighborhood Hits	67
SwissProt Accessions	Q92506, Q9UIQ1	Gene names	HSD17B8, FABGL, HKE6, RING2
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 8 (EC 1.1.1.62) (17-beta-HSD 8) (17- beta-hydroxysteroid dehydrogenase 8) (Protein Ke6) (Ke-6).

DHB2_MOUSE
NC score	0.483614 (rank : 52)	θ value	6.87365e-08 (rank : 19)
Query Neighborhood Hits	74	Target Neighborhood Hits	75	Shared Neighborhood Hits	66
SwissProt Accessions	P51658, O08898	Gene names	Hsd17b2, Edh17b2
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 2 (EC 1.1.1.62) (17-beta-HSD 2) (17- beta-hydroxysteroid dehydrogenase 2).

DHRS4_MOUSE
NC score	0.477774 (rank : 53)	θ value	0.000786445 (rank : 47)
Query Neighborhood Hits	74	Target Neighborhood Hits	67	Shared Neighborhood Hits	64
SwissProt Accessions	Q99LB2, Q9EQU4	Gene names	Dhrs4, D14Ucla2
Domain Architecture
Description	Dehydrogenase/reductase SDR family member 4 (EC 1.1.1.184) (NADPH- dependent carbonyl reductase/NADP-retinol dehydrogenase) (CR) (PHCR) (Peroxisomal short-chain alcohol dehydrogenase) (NADPH-dependent retinol dehydrogenase/reductase) (NDRD) (mouNRDR).

DHB12_HUMAN
NC score	0.462546 (rank : 54)	θ value	0.0431538 (rank : 58)
Query Neighborhood Hits	74	Target Neighborhood Hits	69	Shared Neighborhood Hits	67
SwissProt Accessions	Q53GQ0, Q96JU2, Q9Y6G8	Gene names	HSD17B12
Domain Architecture	No domain graphic available
Description	Estradiol 17-beta-dehydrogenase 12 (EC 1.1.1.62) (17-beta-HSD 12) (17- beta-hydroxysteroid dehydrogenase 12) (3-ketoacyl-CoA reductase) (EC 1.3.1.-) (KAR).

DHB12_MOUSE
NC score	0.447234 (rank : 55)	θ value	0.813845 (rank : 65)
Query Neighborhood Hits	74	Target Neighborhood Hits	70	Shared Neighborhood Hits	67
SwissProt Accessions	O70503, Q3TID1, Q3U7V9, Q542N3, Q8CI39	Gene names	Hsd17b12, Kik1
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 12 (EC 1.1.1.62) (17-beta-HSD 12) (17- beta-hydroxysteroid dehydrogenase 12) (3-ketoacyl-CoA reductase) (EC 1.3.1.-) (KAR) (KIK-I).

DHB3_MOUSE
NC score	0.446416 (rank : 56)	θ value	2.36792 (rank : 66)
Query Neighborhood Hits	74	Target Neighborhood Hits	67	Shared Neighborhood Hits	63
SwissProt Accessions	P70385	Gene names	Hsd17b3, Edh17b3
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 3 (EC 1.1.1.62) (17-beta-HSD 3) (Testicular 17-beta-hydroxysteroid dehydrogenase).

BDH_MOUSE
NC score	0.443260 (rank : 57)	θ value	0.279714 (rank : 64)
Query Neighborhood Hits	74	Target Neighborhood Hits	70	Shared Neighborhood Hits	65
SwissProt Accessions	Q80XN0, Q3UJS9, Q8BK53, Q8R0C8	Gene names	Bdh1, Bdh
Domain Architecture	No domain graphic available
Description	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor (EC 1.1.1.30) (BDH) (3-hydroxybutyrate dehydrogenase).

DECR_MOUSE
NC score	0.442094 (rank : 58)	θ value	0.0563607 (rank : 59)
Query Neighborhood Hits	74	Target Neighborhood Hits	66	Shared Neighborhood Hits	63
SwissProt Accessions	Q9CQ62, Q9DCI7	Gene names	Decr1
Domain Architecture	No domain graphic available
Description	2,4-dienoyl-CoA reductase, mitochondrial precursor (EC 1.3.1.34) (2,4- dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH]).

DHB2_HUMAN
NC score	0.440765 (rank : 59)	θ value	0.0113563 (rank : 55)
Query Neighborhood Hits	74	Target Neighborhood Hits	72	Shared Neighborhood Hits	68
SwissProt Accessions	P37059	Gene names	HSD17B2, EDH17B2
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 2 (EC 1.1.1.62) (17-beta-HSD 2) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (20 alpha- hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH).

DECR2_MOUSE
NC score	0.439545 (rank : 60)	θ value	0.00509761 (rank : 52)
Query Neighborhood Hits	74	Target Neighborhood Hits	63	Shared Neighborhood Hits	60
SwissProt Accessions	Q9WV68	Gene names	Decr2, Pdcr
Domain Architecture	No domain graphic available
Description	Peroxisomal 2,4-dienoyl-CoA reductase (EC 1.3.1.34) (2,4-dienoyl-CoA reductase 2).

HCD2_MOUSE
NC score	0.434299 (rank : 61)	θ value	0.0252991 (rank : 57)
Query Neighborhood Hits	74	Target Neighborhood Hits	65	Shared Neighborhood Hits	61
SwissProt Accessions	O08756	Gene names	Hadh2, Erab, Hsd17b10
Domain Architecture
Description	3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (3-hydroxyacyl- CoA dehydrogenase type II) (Type II HADH) (3-hydroxy-2-methylbutyryl- CoA dehydrogenase) (EC 1.1.1.178) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein).

DHB1_HUMAN
NC score	0.429081 (rank : 62)	θ value	5.27518 (rank : 68)
Query Neighborhood Hits	74	Target Neighborhood Hits	67	Shared Neighborhood Hits	65
SwissProt Accessions	P14061	Gene names	HSD17B1, E17KSR, EDH17B1, EDHB17
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 1 (EC 1.1.1.62) (17-beta- hydroxysteroid dehydrogenase type 1) (17-beta-HSD 1) (Placental 17- beta-hydroxysteroid dehydrogenase) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH).

DHB1_MOUSE
NC score	0.427964 (rank : 63)	θ value	0.0563607 (rank : 60)
Query Neighborhood Hits	74	Target Neighborhood Hits	68	Shared Neighborhood Hits	62
SwissProt Accessions	P51656	Gene names	Hsd17b1, Edh17b1
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 1 (EC 1.1.1.62) (17-beta- hydroxysteroid dehydrogenase type 1) (17-beta-HSD 1).

DECR_HUMAN
NC score	0.427409 (rank : 64)	θ value	0.21417 (rank : 63)
Query Neighborhood Hits	74	Target Neighborhood Hits	66	Shared Neighborhood Hits	62
SwissProt Accessions	Q16698, Q93085	Gene names	DECR1, DECR
Domain Architecture
Description	2,4-dienoyl-CoA reductase, mitochondrial precursor (EC 1.3.1.34) (2,4- dienoyl-CoA reductase [NADPH]) (4-enoyl-CoA reductase [NADPH]).

HCD2_HUMAN
NC score	0.413507 (rank : 65)	θ value	5.27518 (rank : 69)
Query Neighborhood Hits	74	Target Neighborhood Hits	73	Shared Neighborhood Hits	68
SwissProt Accessions	Q99714, Q8TCV9, Q96HD5	Gene names	HADH2, ERAB, HSD17B10, SCHAD, XH98G2
Domain Architecture
Description	3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (3-hydroxyacyl- CoA dehydrogenase type II) (Type II HADH) (3-hydroxy-2-methylbutyryl- CoA dehydrogenase) (EC 1.1.1.178) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Short-chain type dehydrogenase/reductase XH98G2).

DHI2_MOUSE
NC score	0.410452 (rank : 66)	θ value	0.0961366 (rank : 61)
Query Neighborhood Hits	74	Target Neighborhood Hits	65	Shared Neighborhood Hits	60
SwissProt Accessions	P51661, Q91WK3	Gene names	Hsd11b2, Hsd11k
Domain Architecture
Description	Corticosteroid 11-beta-dehydrogenase isozyme 2 (EC 1.1.1.-) (11-DH2) (11-beta-hydroxysteroid dehydrogenase type 2) (11-beta-HSD2) (NAD- dependent 11-beta-hydroxysteroid dehydrogenase).

DHB4_HUMAN
NC score	0.401429 (rank : 67)	θ value	4.1701e-05 (rank : 39)
Query Neighborhood Hits	74	Target Neighborhood Hits	83	Shared Neighborhood Hits	63
SwissProt Accessions	P51659	Gene names	HSD17B4, EDH17B4
Domain Architecture
Description	Peroxisomal multifunctional enzyme type 2 (MFE-2) (D-bifunctional protein) (DBP) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-3-hydroxyacyl-CoA dehydratase) (EC 4.2.1.107) (3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase) (3- hydroxyacyl-CoA dehydrogenase) (EC 1.1.1.35).

DHB4_MOUSE
NC score	0.385986 (rank : 68)	θ value	0.000786445 (rank : 46)
Query Neighborhood Hits	74	Target Neighborhood Hits	78	Shared Neighborhood Hits	63
SwissProt Accessions	P51660, Q9DBM3	Gene names	Hsd17b4, Edh17b4
Domain Architecture
Description	Peroxisomal multifunctional enzyme type 2 (MFE-2) (D-bifunctional protein) (DBP) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-3-hydroxyacyl-CoA dehydratase) (EC 4.2.1.107) (3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase) (3- hydroxyacyl-CoA dehydrogenase) (EC 1.1.1.35).

BDH_HUMAN
NC score	0.383812 (rank : 69)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	74	Target Neighborhood Hits	65	Shared Neighborhood Hits	63
SwissProt Accessions	Q02338, Q96ET1, Q9BRZ4	Gene names	BDH1, BDH
Domain Architecture
Description	D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor (EC 1.1.1.30) (BDH) (3-hydroxybutyrate dehydrogenase).

DHI2_HUMAN
NC score	0.327487 (rank : 70)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	74	Target Neighborhood Hits	62	Shared Neighborhood Hits	59
SwissProt Accessions	P80365, Q13194, Q8N439, Q96QN8, Q9UC50, Q9UC51	Gene names	HSD11B2, HSD11K
Domain Architecture
Description	Corticosteroid 11-beta-dehydrogenase isozyme 2 (EC 1.1.1.-) (11-DH2) (11-beta-hydroxysteroid dehydrogenase type 2) (11-beta-HSD2) (NAD- dependent 11-beta-hydroxysteroid dehydrogenase).

DHB8_MOUSE
NC score	0.321400 (rank : 71)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	74	Target Neighborhood Hits	56	Shared Neighborhood Hits	53
SwissProt Accessions	P50171, Q60958, Q60959, Q9Z1W2	Gene names	Hsd17b8, H2-Ke6, Hke6
Domain Architecture
Description	Estradiol 17-beta-dehydrogenase 8 (EC 1.1.1.62) (17-beta-HSD 8) (17- beta-hydroxysteroid dehydrogenase 8) (Protein Ke6) (Ke-6).

SPRE_MOUSE
NC score	0.212188 (rank : 72)	θ value	0.125558 (rank : 62)
Query Neighborhood Hits	74	Target Neighborhood Hits	47	Shared Neighborhood Hits	40
SwissProt Accessions	Q64105, Q63996	Gene names	Spr
Domain Architecture
Description	Sepiapterin reductase (EC 1.1.1.153) (SPR).

SPRE_HUMAN
NC score	0.142376 (rank : 73)	θ value	3.0926 (rank : 67)
Query Neighborhood Hits	74	Target Neighborhood Hits	32	Shared Neighborhood Hits	29
SwissProt Accessions	P35270	Gene names	SPR
Domain Architecture
Description	Sepiapterin reductase (EC 1.1.1.153) (SPR).

YAP1_MOUSE
NC score	0.052212 (rank : 74)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	74	Target Neighborhood Hits	96	Shared Neighborhood Hits	2
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

SAV1_HUMAN
NC score	0.051731 (rank : 75)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	74	Target Neighborhood Hits	51	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SAV1_MOUSE
NC score	0.051308 (rank : 76)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	74	Target Neighborhood Hits	48	Shared Neighborhood Hits	2
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

RIP_MOUSE
NC score	0.014920 (rank : 77)	θ value	5.27518 (rank : 70)
Query Neighborhood Hits	74	Target Neighborhood Hits	6	Shared Neighborhood Hits	2
SwissProt Accessions	Q9CWY9	Gene names	Rpain, Rip
Domain Architecture	No domain graphic available
Description	RPA-interacting protein.

MECR_HUMAN
NC score	0.009222 (rank : 78)	θ value	8.99809 (rank : 73)
Query Neighborhood Hits	74	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BV79, Q5SYU0, Q5SYU1, Q5SYU2, Q6IBU9, Q9Y373	Gene names	MECR, NBRF1
Domain Architecture	No domain graphic available
Description	Trans-2-enoyl-CoA reductase, mitochondrial precursor (EC 1.3.1.38) (HsNrbf-1) (NRBF-1).

MYH11_HUMAN
NC score	-0.004712 (rank : 79)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	74	Target Neighborhood Hits	1806	Shared Neighborhood Hits	2
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).