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Network neighborhood for query Sequence : WWTR1_MOUSE

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WWTR1_MOUSE
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

WWTR1_HUMAN
θ value	0 (rank : 1)	NC score	0.992829 (rank : 2)
Query Neighborhood Hits	54	Target Neighborhood Hits	76	Shared Neighborhood Hits	44
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

WWTR1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	54	Target Neighborhood Hits	54	Shared Neighborhood Hits	54
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

YAP1_HUMAN
θ value	4.36332e-79 (rank : 3)	NC score	0.922775 (rank : 3)
Query Neighborhood Hits	54	Target Neighborhood Hits	173	Shared Neighborhood Hits	41
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

YAP1_MOUSE
θ value	4.68348e-65 (rank : 4)	NC score	0.904695 (rank : 4)
Query Neighborhood Hits	54	Target Neighborhood Hits	96	Shared Neighborhood Hits	41
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

ITCH_HUMAN
θ value	3.19293e-05 (rank : 5)	NC score	0.379304 (rank : 14)
Query Neighborhood Hits	54	Target Neighborhood Hits	162	Shared Neighborhood Hits	41
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

ITCH_MOUSE
θ value	3.19293e-05 (rank : 6)	NC score	0.381258 (rank : 12)
Query Neighborhood Hits	54	Target Neighborhood Hits	127	Shared Neighborhood Hits	41
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

WWP2_HUMAN
θ value	3.19293e-05 (rank : 7)	NC score	0.382767 (rank : 11)
Query Neighborhood Hits	54	Target Neighborhood Hits	177	Shared Neighborhood Hits	39
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP2_MOUSE
θ value	3.19293e-05 (rank : 8)	NC score	0.383664 (rank : 10)
Query Neighborhood Hits	54	Target Neighborhood Hits	118	Shared Neighborhood Hits	39
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

NEDD4_MOUSE
θ value	4.1701e-05 (rank : 9)	NC score	0.353588 (rank : 21)
Query Neighborhood Hits	54	Target Neighborhood Hits	212	Shared Neighborhood Hits	41
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

SMUF2_HUMAN
θ value	4.1701e-05 (rank : 10)	NC score	0.367195 (rank : 15)
Query Neighborhood Hits	54	Target Neighborhood Hits	142	Shared Neighborhood Hits	37
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

NEDD4_HUMAN
θ value	5.44631e-05 (rank : 11)	NC score	0.355080 (rank : 19)
Query Neighborhood Hits	54	Target Neighborhood Hits	214	Shared Neighborhood Hits	39
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

NED4L_HUMAN
θ value	7.1131e-05 (rank : 12)	NC score	0.352715 (rank : 22)
Query Neighborhood Hits	54	Target Neighborhood Hits	238	Shared Neighborhood Hits	41
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_MOUSE
θ value	7.1131e-05 (rank : 13)	NC score	0.354024 (rank : 20)
Query Neighborhood Hits	54	Target Neighborhood Hits	231	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

WWP1_HUMAN
θ value	7.1131e-05 (rank : 14)	NC score	0.379666 (rank : 13)
Query Neighborhood Hits	54	Target Neighborhood Hits	262	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

WWP1_MOUSE
θ value	7.1131e-05 (rank : 15)	NC score	0.387002 (rank : 9)
Query Neighborhood Hits	54	Target Neighborhood Hits	138	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

MAGI1_HUMAN
θ value	9.29e-05 (rank : 16)	NC score	0.296401 (rank : 32)
Query Neighborhood Hits	54	Target Neighborhood Hits	388	Shared Neighborhood Hits	37
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

MAGI1_MOUSE
θ value	9.29e-05 (rank : 17)	NC score	0.296441 (rank : 31)
Query Neighborhood Hits	54	Target Neighborhood Hits	403	Shared Neighborhood Hits	37
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MAGI2_MOUSE
θ value	9.29e-05 (rank : 18)	NC score	0.313962 (rank : 29)
Query Neighborhood Hits	54	Target Neighborhood Hits	370	Shared Neighborhood Hits	41
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

MAGI2_HUMAN
θ value	0.000158464 (rank : 19)	NC score	0.306625 (rank : 30)
Query Neighborhood Hits	54	Target Neighborhood Hits	373	Shared Neighborhood Hits	37
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

SMUF1_HUMAN
θ value	0.000158464 (rank : 20)	NC score	0.357175 (rank : 18)
Query Neighborhood Hits	54	Target Neighborhood Hits	135	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
θ value	0.000158464 (rank : 21)	NC score	0.361418 (rank : 16)
Query Neighborhood Hits	54	Target Neighborhood Hits	142	Shared Neighborhood Hits	37
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

BAG3_HUMAN
θ value	0.000270298 (rank : 22)	NC score	0.361164 (rank : 17)
Query Neighborhood Hits	54	Target Neighborhood Hits	314	Shared Neighborhood Hits	36
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

WWC1_HUMAN
θ value	0.00035302 (rank : 23)	NC score	0.392885 (rank : 7)
Query Neighborhood Hits	54	Target Neighborhood Hits	290	Shared Neighborhood Hits	36
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
θ value	0.000602161 (rank : 24)	NC score	0.388151 (rank : 8)
Query Neighborhood Hits	54	Target Neighborhood Hits	290	Shared Neighborhood Hits	33
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

SAV1_HUMAN
θ value	0.000786445 (rank : 25)	NC score	0.467394 (rank : 5)
Query Neighborhood Hits	54	Target Neighborhood Hits	51	Shared Neighborhood Hits	39
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SAV1_MOUSE
θ value	0.000786445 (rank : 26)	NC score	0.466323 (rank : 6)
Query Neighborhood Hits	54	Target Neighborhood Hits	48	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

BAG3_MOUSE
θ value	0.00102713 (rank : 27)	NC score	0.319069 (rank : 28)
Query Neighborhood Hits	54	Target Neighborhood Hits	513	Shared Neighborhood Hits	37
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

PKHA5_HUMAN
θ value	0.00102713 (rank : 28)	NC score	0.246808 (rank : 33)
Query Neighborhood Hits	54	Target Neighborhood Hits	455	Shared Neighborhood Hits	33
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

WWOX_HUMAN
θ value	0.00102713 (rank : 29)	NC score	0.337108 (rank : 24)
Query Neighborhood Hits	54	Target Neighborhood Hits	115	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

WWOX_MOUSE
θ value	0.00102713 (rank : 30)	NC score	0.334222 (rank : 25)
Query Neighborhood Hits	54	Target Neighborhood Hits	118	Shared Neighborhood Hits	39
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

STXB4_HUMAN
θ value	0.00298849 (rank : 31)	NC score	0.222685 (rank : 37)
Query Neighborhood Hits	54	Target Neighborhood Hits	616	Shared Neighborhood Hits	41
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_MOUSE
θ value	0.00298849 (rank : 32)	NC score	0.225954 (rank : 36)
Query Neighborhood Hits	54	Target Neighborhood Hits	629	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

GAS7_MOUSE
θ value	0.0330416 (rank : 33)	NC score	0.244379 (rank : 34)
Query Neighborhood Hits	54	Target Neighborhood Hits	259	Shared Neighborhood Hits	35
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

PIN1_HUMAN
θ value	0.0431538 (rank : 34)	NC score	0.326469 (rank : 27)
Query Neighborhood Hits	54	Target Neighborhood Hits	59	Shared Neighborhood Hits	35
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PIN1_MOUSE
θ value	0.0431538 (rank : 35)	NC score	0.331726 (rank : 26)
Query Neighborhood Hits	54	Target Neighborhood Hits	60	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

GAS7_HUMAN
θ value	0.0736092 (rank : 36)	NC score	0.230005 (rank : 35)
Query Neighborhood Hits	54	Target Neighborhood Hits	258	Shared Neighborhood Hits	36
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

PINL_HUMAN
θ value	0.0961366 (rank : 37)	NC score	0.351807 (rank : 23)
Query Neighborhood Hits	54	Target Neighborhood Hits	47	Shared Neighborhood Hits	34
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

DGCR8_HUMAN
θ value	0.47712 (rank : 38)	NC score	0.111621 (rank : 58)
Query Neighborhood Hits	54	Target Neighborhood Hits	72	Shared Neighborhood Hits	14
SwissProt Accessions	Q8WYQ5, Q6DCB2, Q6MZE9, Q6Y2L0, Q96G39, Q96GP8, Q9H6L8, Q9H6T7, Q9NRW2	Gene names	DGCR8, C22orf12, DGCRK6
Domain Architecture
Description	DGCR8 protein (DiGeorge syndrome critical region 8).

DGCR8_MOUSE
θ value	0.47712 (rank : 39)	NC score	0.110836 (rank : 59)
Query Neighborhood Hits	54	Target Neighborhood Hits	70	Shared Neighborhood Hits	14
SwissProt Accessions	Q9EQM6	Gene names	Dgcr8
Domain Architecture	No domain graphic available
Description	DGCR8 protein (DiGeorge syndrome critical region 8 homolog) (Gy1).

DMD_HUMAN
θ value	0.813845 (rank : 40)	NC score	0.045075 (rank : 70)
Query Neighborhood Hits	54	Target Neighborhood Hits	1135	Shared Neighborhood Hits	29
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

DMD_MOUSE
θ value	0.813845 (rank : 41)	NC score	0.042302 (rank : 71)
Query Neighborhood Hits	54	Target Neighborhood Hits	1111	Shared Neighborhood Hits	29
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

BTBDC_HUMAN
θ value	1.38821 (rank : 42)	NC score	0.049062 (rank : 69)
Query Neighborhood Hits	54	Target Neighborhood Hits	248	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IY92, Q96JP1	Gene names	BTBD12, KIAA1784
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 12.

TLK2_MOUSE
θ value	1.81305 (rank : 43)	NC score	0.003410 (rank : 82)
Query Neighborhood Hits	54	Target Neighborhood Hits	1088	Shared Neighborhood Hits	4
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

MYH7_HUMAN
θ value	3.0926 (rank : 44)	NC score	0.008653 (rank : 77)
Query Neighborhood Hits	54	Target Neighborhood Hits	1559	Shared Neighborhood Hits	13
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

USF2_MOUSE
θ value	3.0926 (rank : 45)	NC score	0.029898 (rank : 72)
Query Neighborhood Hits	54	Target Neighborhood Hits	173	Shared Neighborhood Hits	4
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

GABR2_HUMAN
θ value	4.03905 (rank : 46)	NC score	0.014648 (rank : 75)
Query Neighborhood Hits	54	Target Neighborhood Hits	101	Shared Neighborhood Hits	2
SwissProt Accessions	O75899, O75974, O75975, Q5VXZ2, Q8WX04, Q9P1R2, Q9UNR1, Q9UNS9	Gene names	GABBR2, GPR51, GPRC3B
Domain Architecture
Description	Gamma-aminobutyric acid type B receptor, subunit 2 precursor (GABA-B receptor 2) (GABA-B-R2) (Gb2) (GABABR2) (G-protein coupled receptor 51) (HG20).

USF2_HUMAN
θ value	4.03905 (rank : 47)	NC score	0.028958 (rank : 73)
Query Neighborhood Hits	54	Target Neighborhood Hits	155	Shared Neighborhood Hits	4
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

ADA29_HUMAN
θ value	5.27518 (rank : 48)	NC score	0.004386 (rank : 81)
Query Neighborhood Hits	54	Target Neighborhood Hits	247	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UKF5, Q9UHP1, Q9UKF3, Q9UKF4	Gene names	ADAM29
Domain Architecture
Description	ADAM 29 precursor (A disintegrin and metalloproteinase domain 29).

CIZ1_HUMAN
θ value	5.27518 (rank : 49)	NC score	0.016654 (rank : 74)
Query Neighborhood Hits	54	Target Neighborhood Hits	359	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ULV3, Q9NYM8, Q9UHK4, Q9Y3F9, Q9Y3G0	Gene names	CIZ1, LSFR1, NP94
Domain Architecture	No domain graphic available
Description	Cip1-interacting zinc finger protein (Nuclear protein NP94).

INSR_MOUSE
θ value	5.27518 (rank : 50)	NC score	-0.001131 (rank : 83)
Query Neighborhood Hits	54	Target Neighborhood Hits	968	Shared Neighborhood Hits	2
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].

ANKY1_HUMAN
θ value	8.99809 (rank : 51)	NC score	0.008405 (rank : 78)
Query Neighborhood Hits	54	Target Neighborhood Hits	248	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P2S6, Q8IYX5, Q8NDK5, Q9NX10	Gene names	ANKMY1, TSAL1, ZMYND13
Domain Architecture
Description	Ankyrin repeat and MYND domain-containing protein 1 (Testis-specific ankyrin-like protein 1) (Zinc-finger MYND domain-containing protein 13).

BRCA1_HUMAN
θ value	8.99809 (rank : 52)	NC score	0.006082 (rank : 80)
Query Neighborhood Hits	54	Target Neighborhood Hits	381	Shared Neighborhood Hits	2
SwissProt Accessions	P38398	Gene names	BRCA1, RNF53
Domain Architecture
Description	Breast cancer type 1 susceptibility protein (RING finger protein 53).

K0157_MOUSE
θ value	8.99809 (rank : 53)	NC score	0.011495 (rank : 76)
Query Neighborhood Hits	54	Target Neighborhood Hits	116	Shared Neighborhood Hits	2
SwissProt Accessions	Q3TCJ1, Q3TB08, Q8K0R4	Gene names	Kiaa0157
Domain Architecture	No domain graphic available
Description	Protein KIAA0157.

TRPM6_MOUSE
θ value	8.99809 (rank : 54)	NC score	0.006862 (rank : 79)
Query Neighborhood Hits	54	Target Neighborhood Hits	78	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CIR4	Gene names	Trpm6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6).

APBB2_HUMAN
θ value	θ > 10 (rank : 55)	NC score	0.057252 (rank : 67)
Query Neighborhood Hits	54	Target Neighborhood Hits	96	Shared Neighborhood Hits	21
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

DRP2_HUMAN
θ value	θ > 10 (rank : 56)	NC score	0.078995 (rank : 62)
Query Neighborhood Hits	54	Target Neighborhood Hits	186	Shared Neighborhood Hits	22
SwissProt Accessions	Q13474	Gene names	DRP2
Domain Architecture
Description	Dystrophin-related protein 2.

EDD1_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.130800 (rank : 53)
Query Neighborhood Hits	54	Target Neighborhood Hits	170	Shared Neighborhood Hits	13
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

EDD1_MOUSE
θ value	θ > 10 (rank : 58)	NC score	0.130963 (rank : 52)
Query Neighborhood Hits	54	Target Neighborhood Hits	167	Shared Neighborhood Hits	13
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

HECD1_HUMAN
θ value	θ > 10 (rank : 59)	NC score	0.115877 (rank : 57)
Query Neighborhood Hits	54	Target Neighborhood Hits	371	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

HECD2_HUMAN
θ value	θ > 10 (rank : 60)	NC score	0.187316 (rank : 43)
Query Neighborhood Hits	54	Target Neighborhood Hits	41	Shared Neighborhood Hits	13
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_MOUSE
θ value	θ > 10 (rank : 61)	NC score	0.188357 (rank : 42)
Query Neighborhood Hits	54	Target Neighborhood Hits	38	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD3_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.129792 (rank : 54)
Query Neighborhood Hits	54	Target Neighborhood Hits	49	Shared Neighborhood Hits	13
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HECD3_MOUSE
θ value	θ > 10 (rank : 63)	NC score	0.132098 (rank : 51)
Query Neighborhood Hits	54	Target Neighborhood Hits	47	Shared Neighborhood Hits	13
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HERC2_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.122090 (rank : 56)
Query Neighborhood Hits	54	Target Neighborhood Hits	163	Shared Neighborhood Hits	15
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_MOUSE
θ value	θ > 10 (rank : 65)	NC score	0.123484 (rank : 55)
Query Neighborhood Hits	54	Target Neighborhood Hits	167	Shared Neighborhood Hits	15
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC3_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.152482 (rank : 50)
Query Neighborhood Hits	54	Target Neighborhood Hits	62	Shared Neighborhood Hits	13
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

HERC5_HUMAN
θ value	θ > 10 (rank : 67)	NC score	0.156958 (rank : 49)
Query Neighborhood Hits	54	Target Neighborhood Hits	66	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HUWE1_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.191052 (rank : 41)
Query Neighborhood Hits	54	Target Neighborhood Hits	443	Shared Neighborhood Hits	14
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	θ > 10 (rank : 69)	NC score	0.191372 (rank : 40)
Query Neighborhood Hits	54	Target Neighborhood Hits	406	Shared Neighborhood Hits	14
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

K0317_HUMAN
θ value	θ > 10 (rank : 70)	NC score	0.197508 (rank : 38)
Query Neighborhood Hits	54	Target Neighborhood Hits	46	Shared Neighborhood Hits	13
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
θ value	θ > 10 (rank : 71)	NC score	0.197434 (rank : 39)
Query Neighborhood Hits	54	Target Neighborhood Hits	43	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

PRP40_HUMAN
θ value	θ > 10 (rank : 72)	NC score	0.098124 (rank : 60)
Query Neighborhood Hits	54	Target Neighborhood Hits	442	Shared Neighborhood Hits	27
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

PRP40_MOUSE
θ value	θ > 10 (rank : 73)	NC score	0.091606 (rank : 61)
Query Neighborhood Hits	54	Target Neighborhood Hits	447	Shared Neighborhood Hits	26
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

RHG12_HUMAN
θ value	θ > 10 (rank : 74)	NC score	0.057968 (rank : 66)
Query Neighborhood Hits	54	Target Neighborhood Hits	190	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

RHG12_MOUSE
θ value	θ > 10 (rank : 75)	NC score	0.068133 (rank : 64)
Query Neighborhood Hits	54	Target Neighborhood Hits	204	Shared Neighborhood Hits	24
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

SETD2_HUMAN
θ value	θ > 10 (rank : 76)	NC score	0.075424 (rank : 63)
Query Neighborhood Hits	54	Target Neighborhood Hits	412	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

TRIPC_HUMAN
θ value	θ > 10 (rank : 77)	NC score	0.168209 (rank : 48)
Query Neighborhood Hits	54	Target Neighborhood Hits	319	Shared Neighborhood Hits	15
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

UBE3A_HUMAN
θ value	θ > 10 (rank : 78)	NC score	0.182634 (rank : 44)
Query Neighborhood Hits	54	Target Neighborhood Hits	49	Shared Neighborhood Hits	13
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3A_MOUSE
θ value	θ > 10 (rank : 79)	NC score	0.180222 (rank : 46)
Query Neighborhood Hits	54	Target Neighborhood Hits	47	Shared Neighborhood Hits	13
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

UBE3C_HUMAN
θ value	θ > 10 (rank : 80)	NC score	0.180604 (rank : 45)
Query Neighborhood Hits	54	Target Neighborhood Hits	51	Shared Neighborhood Hits	13
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
θ value	θ > 10 (rank : 81)	NC score	0.179948 (rank : 47)
Query Neighborhood Hits	54	Target Neighborhood Hits	48	Shared Neighborhood Hits	13
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

WBP4_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.056232 (rank : 68)
Query Neighborhood Hits	54	Target Neighborhood Hits	100	Shared Neighborhood Hits	21
SwissProt Accessions	Q61048, Q8K1Z9, Q9CS45	Gene names	Wbp4, Fbp21, Fnbp21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

WWC3_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.059776 (rank : 65)
Query Neighborhood Hits	54	Target Neighborhood Hits	193	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ULE0, Q659C1, Q9BTQ1	Gene names	WWC3, KIAA1280
Domain Architecture	No domain graphic available
Description	WWC family member 3.

Hits sorted by NC score

WWTR1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	54	Target Neighborhood Hits	54	Shared Neighborhood Hits	54
SwissProt Accessions	Q9EPK5, Q99KI4	Gene names	Wwtr1, Taz
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

WWTR1_HUMAN
NC score	0.992829 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	54	Target Neighborhood Hits	76	Shared Neighborhood Hits	44
SwissProt Accessions	Q9GZV5, Q8N3P2, Q9Y3W6	Gene names	WWTR1, TAZ
Domain Architecture	No domain graphic available
Description	WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif).

YAP1_HUMAN
NC score	0.922775 (rank : 3)	θ value	4.36332e-79 (rank : 3)
Query Neighborhood Hits	54	Target Neighborhood Hits	173	Shared Neighborhood Hits	41
SwissProt Accessions	P46937	Gene names	YAP1, YAP65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

YAP1_MOUSE
NC score	0.904695 (rank : 4)	θ value	4.68348e-65 (rank : 4)
Query Neighborhood Hits	54	Target Neighborhood Hits	96	Shared Neighborhood Hits	41
SwissProt Accessions	P46938, Q52KJ5	Gene names	Yap1, Yap, Yap65
Domain Architecture
Description	65 kDa Yes-associated protein (YAP65).

SAV1_HUMAN
NC score	0.467394 (rank : 5)	θ value	0.000786445 (rank : 25)
Query Neighborhood Hits	54	Target Neighborhood Hits	51	Shared Neighborhood Hits	39
SwissProt Accessions	Q9H4B6, Q6IA58, Q9H949, Q9HAK9	Gene names	SAV1, WW45
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (hWW45).

SAV1_MOUSE
NC score	0.466323 (rank : 6)	θ value	0.000786445 (rank : 26)
Query Neighborhood Hits	54	Target Neighborhood Hits	48	Shared Neighborhood Hits	39
SwissProt Accessions	Q8VEB2, Q9D9N9, Q9ER46	Gene names	Sav1, Ww45, Wwp3
Domain Architecture
Description	Salvador homolog 1 protein (45 kDa WW domain protein) (mWW45).

WWC1_HUMAN
NC score	0.392885 (rank : 7)	θ value	0.00035302 (rank : 23)
Query Neighborhood Hits	54	Target Neighborhood Hits	290	Shared Neighborhood Hits	36
SwissProt Accessions	Q8IX03, O94946, Q6MZX4, Q6Y2F8, Q7Z4G8, Q8WVM4, Q9BT29	Gene names	WWC1, KIAA0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA) (HBeAg-binding protein 3).

WWC1_MOUSE
NC score	0.388151 (rank : 8)	θ value	0.000602161 (rank : 24)
Query Neighborhood Hits	54	Target Neighborhood Hits	290	Shared Neighborhood Hits	33
SwissProt Accessions	Q5SXA9, Q571D0, Q8K1Y3, Q8VD17, Q922W3	Gene names	Wwc1, Kiaa0869
Domain Architecture	No domain graphic available
Description	WW domain-containing protein 1 (Kidney and brain protein) (KIBRA).

WWP1_MOUSE
NC score	0.387002 (rank : 9)	θ value	7.1131e-05 (rank : 15)
Query Neighborhood Hits	54	Target Neighborhood Hits	138	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

WWP2_MOUSE
NC score	0.383664 (rank : 10)	θ value	3.19293e-05 (rank : 8)
Query Neighborhood Hits	54	Target Neighborhood Hits	118	Shared Neighborhood Hits	39
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

WWP2_HUMAN
NC score	0.382767 (rank : 11)	θ value	3.19293e-05 (rank : 7)
Query Neighborhood Hits	54	Target Neighborhood Hits	177	Shared Neighborhood Hits	39
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

ITCH_MOUSE
NC score	0.381258 (rank : 12)	θ value	3.19293e-05 (rank : 6)
Query Neighborhood Hits	54	Target Neighborhood Hits	127	Shared Neighborhood Hits	41
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

WWP1_HUMAN
NC score	0.379666 (rank : 13)	θ value	7.1131e-05 (rank : 14)
Query Neighborhood Hits	54	Target Neighborhood Hits	262	Shared Neighborhood Hits	41
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

ITCH_HUMAN
NC score	0.379304 (rank : 14)	θ value	3.19293e-05 (rank : 5)
Query Neighborhood Hits	54	Target Neighborhood Hits	162	Shared Neighborhood Hits	41
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

SMUF2_HUMAN
NC score	0.367195 (rank : 15)	θ value	4.1701e-05 (rank : 10)
Query Neighborhood Hits	54	Target Neighborhood Hits	142	Shared Neighborhood Hits	37
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SMUF1_MOUSE
NC score	0.361418 (rank : 16)	θ value	0.000158464 (rank : 21)
Query Neighborhood Hits	54	Target Neighborhood Hits	142	Shared Neighborhood Hits	37
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

BAG3_HUMAN
NC score	0.361164 (rank : 17)	θ value	0.000270298 (rank : 22)
Query Neighborhood Hits	54	Target Neighborhood Hits	314	Shared Neighborhood Hits	36
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

SMUF1_HUMAN
NC score	0.357175 (rank : 18)	θ value	0.000158464 (rank : 20)
Query Neighborhood Hits	54	Target Neighborhood Hits	135	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

NEDD4_HUMAN
NC score	0.355080 (rank : 19)	θ value	5.44631e-05 (rank : 11)
Query Neighborhood Hits	54	Target Neighborhood Hits	214	Shared Neighborhood Hits	39
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

NED4L_MOUSE
NC score	0.354024 (rank : 20)	θ value	7.1131e-05 (rank : 13)
Query Neighborhood Hits	54	Target Neighborhood Hits	231	Shared Neighborhood Hits	41
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NEDD4_MOUSE
NC score	0.353588 (rank : 21)	θ value	4.1701e-05 (rank : 9)
Query Neighborhood Hits	54	Target Neighborhood Hits	212	Shared Neighborhood Hits	41
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

NED4L_HUMAN
NC score	0.352715 (rank : 22)	θ value	7.1131e-05 (rank : 12)
Query Neighborhood Hits	54	Target Neighborhood Hits	238	Shared Neighborhood Hits	41
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

PINL_HUMAN
NC score	0.351807 (rank : 23)	θ value	0.0961366 (rank : 37)
Query Neighborhood Hits	54	Target Neighborhood Hits	47	Shared Neighborhood Hits	34
SwissProt Accessions	O15428	Gene names	PIN1L
Domain Architecture
Description	PIN1-like protein.

WWOX_HUMAN
NC score	0.337108 (rank : 24)	θ value	0.00102713 (rank : 29)
Query Neighborhood Hits	54	Target Neighborhood Hits	115	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NZC7, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5	Gene names	WWOX, FOR, WOX1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-) (Fragile site FRA16D oxidoreductase).

WWOX_MOUSE
NC score	0.334222 (rank : 25)	θ value	0.00102713 (rank : 30)
Query Neighborhood Hits	54	Target Neighborhood Hits	118	Shared Neighborhood Hits	39
SwissProt Accessions	Q91WL8, Q8C8J6, Q920Y2, Q9D2B3, Q9D339, Q9JLF5	Gene names	Wwox, Wox1
Domain Architecture	No domain graphic available
Description	WW domain-containing oxidoreductase (EC 1.1.1.-).

PIN1_MOUSE
NC score	0.331726 (rank : 26)	θ value	0.0431538 (rank : 35)
Query Neighborhood Hits	54	Target Neighborhood Hits	60	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QUR7, Q543B3	Gene names	Pin1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

PIN1_HUMAN
NC score	0.326469 (rank : 27)	θ value	0.0431538 (rank : 34)
Query Neighborhood Hits	54	Target Neighborhood Hits	59	Shared Neighborhood Hits	35
SwissProt Accessions	Q13526	Gene names	PIN1
Domain Architecture
Description	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Rotamase Pin1) (PPIase Pin1).

BAG3_MOUSE
NC score	0.319069 (rank : 28)	θ value	0.00102713 (rank : 27)
Query Neighborhood Hits	54	Target Neighborhood Hits	513	Shared Neighborhood Hits	37
SwissProt Accessions	Q9JLV1, Q9JJC7	Gene names	Bag3, Bis
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis).

MAGI2_MOUSE
NC score	0.313962 (rank : 29)	θ value	9.29e-05 (rank : 18)
Query Neighborhood Hits	54	Target Neighborhood Hits	370	Shared Neighborhood Hits	41
SwissProt Accessions	Q9WVQ1, Q3UH81, Q6GT88, Q8BYT1, Q8CA85	Gene names	Magi2, Acvrinp1, Aip1, Arip1
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Activin receptor-interacting protein 1) (Acvrip1).

MAGI2_HUMAN
NC score	0.306625 (rank : 30)	θ value	0.000158464 (rank : 19)
Query Neighborhood Hits	54	Target Neighborhood Hits	373	Shared Neighborhood Hits	37
SwissProt Accessions	Q86UL8, O60434, O60510, Q86UI7, Q9NP44, Q9UDQ5, Q9UDU1	Gene names	MAGI2, ACVRINP1, AIP1, KIAA0705
Domain Architecture
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 (Membrane-associated guanylate kinase inverted 2) (MAGI-2) (Atrophin-1-interacting protein 1) (Atrophin-1-interacting protein A).

MAGI1_MOUSE
NC score	0.296441 (rank : 31)	θ value	9.29e-05 (rank : 17)
Query Neighborhood Hits	54	Target Neighborhood Hits	403	Shared Neighborhood Hits	37
SwissProt Accessions	Q6RHR9, O54893, O54894, O54895	Gene names	Magi1, Baiap1, Bap1
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1).

MAGI1_HUMAN
NC score	0.296401 (rank : 32)	θ value	9.29e-05 (rank : 16)
Query Neighborhood Hits	54	Target Neighborhood Hits	388	Shared Neighborhood Hits	37
SwissProt Accessions	Q96QZ7, O00309, O43863, O75085, Q96QZ8, Q96QZ9	Gene names	MAGI1, BAIAP1, BAP1, TNRC19
Domain Architecture	No domain graphic available
Description	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (BAI1-associated protein 1) (BAP-1) (Membrane-associated guanylate kinase inverted 1) (MAGI-1) (Atrophin-1-interacting protein 3) (AIP3) (WW domain-containing protein 3) (WWP3) (Trinucleotide repeat-containing gene 19 protein).

PKHA5_HUMAN
NC score	0.246808 (rank : 33)	θ value	0.00102713 (rank : 28)
Query Neighborhood Hits	54	Target Neighborhood Hits	455	Shared Neighborhood Hits	33
SwissProt Accessions	Q9HAU0, Q8N3K6, Q96DY9, Q9BVR4, Q9C0H7, Q9H924, Q9NVK8	Gene names	PLEKHA5, KIAA1686, PEPP2
Domain Architecture
Description	Pleckstrin homology domain-containing family A member 5 (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2).

GAS7_MOUSE
NC score	0.244379 (rank : 34)	θ value	0.0330416 (rank : 33)
Query Neighborhood Hits	54	Target Neighborhood Hits	259	Shared Neighborhood Hits	35
SwissProt Accessions	Q60780, Q9QY25, Q9QY26, Q9QY34	Gene names	Gas7
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

GAS7_HUMAN
NC score	0.230005 (rank : 35)	θ value	0.0736092 (rank : 36)
Query Neighborhood Hits	54	Target Neighborhood Hits	258	Shared Neighborhood Hits	36
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

STXB4_MOUSE
NC score	0.225954 (rank : 36)	θ value	0.00298849 (rank : 32)
Query Neighborhood Hits	54	Target Neighborhood Hits	629	Shared Neighborhood Hits	40
SwissProt Accessions	Q9WV89, Q5SUA6, Q5SUA8, Q5SUA9, Q8CFL1	Gene names	Stxbp4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

STXB4_HUMAN
NC score	0.222685 (rank : 37)	θ value	0.00298849 (rank : 31)
Query Neighborhood Hits	54	Target Neighborhood Hits	616	Shared Neighborhood Hits	41
SwissProt Accessions	Q6ZWJ1, Q8IVZ5	Gene names	STXBP4
Domain Architecture	No domain graphic available
Description	Syntaxin-binding protein 4 (Syntaxin 4-interacting protein) (Synip).

K0317_HUMAN
NC score	0.197508 (rank : 38)	θ value	θ > 10 (rank : 70)
Query Neighborhood Hits	54	Target Neighborhood Hits	46	Shared Neighborhood Hits	13
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
NC score	0.197434 (rank : 39)	θ value	θ > 10 (rank : 71)
Query Neighborhood Hits	54	Target Neighborhood Hits	43	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

HUWE1_MOUSE
NC score	0.191372 (rank : 40)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	54	Target Neighborhood Hits	406	Shared Neighborhood Hits	14
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

HUWE1_HUMAN
NC score	0.191052 (rank : 41)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	54	Target Neighborhood Hits	443	Shared Neighborhood Hits	14
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HECD2_MOUSE
NC score	0.188357 (rank : 42)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	54	Target Neighborhood Hits	38	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_HUMAN
NC score	0.187316 (rank : 43)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	54	Target Neighborhood Hits	41	Shared Neighborhood Hits	13
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

UBE3A_HUMAN
NC score	0.182634 (rank : 44)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	54	Target Neighborhood Hits	49	Shared Neighborhood Hits	13
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3C_HUMAN
NC score	0.180604 (rank : 45)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	54	Target Neighborhood Hits	51	Shared Neighborhood Hits	13
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3A_MOUSE
NC score	0.180222 (rank : 46)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	54	Target Neighborhood Hits	47	Shared Neighborhood Hits	13
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

UBE3C_MOUSE
NC score	0.179948 (rank : 47)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	54	Target Neighborhood Hits	48	Shared Neighborhood Hits	13
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

TRIPC_HUMAN
NC score	0.168209 (rank : 48)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	54	Target Neighborhood Hits	319	Shared Neighborhood Hits	15
SwissProt Accessions	Q14669, Q15644	Gene names	TRIP12, KIAA0045
Domain Architecture
Description	Thyroid receptor-interacting protein 12 (TRIP12).

HERC5_HUMAN
NC score	0.156958 (rank : 49)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	54	Target Neighborhood Hits	66	Shared Neighborhood Hits	13
SwissProt Accessions	Q9UII4	Gene names	HERC5, CEB1, CEBP1
Domain Architecture
Description	HECT domain and RCC1-like domain-containing protein 5 (Cyclin-E- binding protein 1).

HERC3_HUMAN
NC score	0.152482 (rank : 50)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	54	Target Neighborhood Hits	62	Shared Neighborhood Hits	13
SwissProt Accessions	Q15034	Gene names	HERC3, KIAA0032
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain protein 3.

HECD3_MOUSE
NC score	0.132098 (rank : 51)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	54	Target Neighborhood Hits	47	Shared Neighborhood Hits	13
SwissProt Accessions	Q3U487, Q3TN76, Q641P3, Q8BQ74, Q8R1L6	Gene names	Hectd3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

EDD1_MOUSE
NC score	0.130963 (rank : 52)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	54	Target Neighborhood Hits	167	Shared Neighborhood Hits	13
SwissProt Accessions	Q80TP3, Q698K9, Q6PEQ8, Q6PFQ9, Q80VL4, Q810V6, Q9CXE9	Gene names	Edd1, Edd, Kiaa0896
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog).

EDD1_HUMAN
NC score	0.130800 (rank : 53)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	54	Target Neighborhood Hits	170	Shared Neighborhood Hits	13
SwissProt Accessions	O95071, O94970, Q9NPL3	Gene names	EDD1, EDD, HYD, KIAA0896
Domain Architecture
Description	Ubiquitin-protein ligase EDD1 (EC 6.3.2.-) (Hyperplastic discs protein homolog) (hHYD) (Progestin-induced protein).

HECD3_HUMAN
NC score	0.129792 (rank : 54)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	54	Target Neighborhood Hits	49	Shared Neighborhood Hits	13
SwissProt Accessions	Q5T447, Q5T448, Q9H783	Gene names	HECTD3
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD3 (HECT domain-containing protein 3).

HERC2_MOUSE
NC score	0.123484 (rank : 55)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	54	Target Neighborhood Hits	167	Shared Neighborhood Hits	15
SwissProt Accessions	Q4U2R1, O88473, Q3TRJ8, Q3TS47, Q3TST2, Q3UFQ6, Q3URH7, Q5DU32, Q7TPR5, Q80VV7, Q9QYT1, Q9Z168, Q9Z171	Gene names	Herc2, jdf2, Kiaa0393, rjs
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HERC2_HUMAN
NC score	0.122090 (rank : 56)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	54	Target Neighborhood Hits	163	Shared Neighborhood Hits	15
SwissProt Accessions	O95714, Q86SV7, Q86SV8, Q86SV9, Q86YY3, Q86YY4, Q86YY5, Q86YY6, Q86YY7, Q86YY8, Q86YY9, Q86YZ0, Q86YZ1	Gene names	HERC2
Domain Architecture	No domain graphic available
Description	HECT domain and RCC1-like domain-containing protein 2.

HECD1_HUMAN
NC score	0.115877 (rank : 57)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	54	Target Neighborhood Hits	371	Shared Neighborhood Hits	13
SwissProt Accessions	Q9ULT8, Q6P445, Q86VJ1, Q96F34, Q9UFZ7	Gene names	HECTD1, KIAA1131
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase HECTD1 (HECT domain-containing protein 1) (E3 ligase for inhibin receptor) (EULIR).

DGCR8_HUMAN
NC score	0.111621 (rank : 58)	θ value	0.47712 (rank : 38)
Query Neighborhood Hits	54	Target Neighborhood Hits	72	Shared Neighborhood Hits	14
SwissProt Accessions	Q8WYQ5, Q6DCB2, Q6MZE9, Q6Y2L0, Q96G39, Q96GP8, Q9H6L8, Q9H6T7, Q9NRW2	Gene names	DGCR8, C22orf12, DGCRK6
Domain Architecture
Description	DGCR8 protein (DiGeorge syndrome critical region 8).

DGCR8_MOUSE
NC score	0.110836 (rank : 59)	θ value	0.47712 (rank : 39)
Query Neighborhood Hits	54	Target Neighborhood Hits	70	Shared Neighborhood Hits	14
SwissProt Accessions	Q9EQM6	Gene names	Dgcr8
Domain Architecture	No domain graphic available
Description	DGCR8 protein (DiGeorge syndrome critical region 8 homolog) (Gy1).

PRP40_HUMAN
NC score	0.098124 (rank : 60)	θ value	θ > 10 (rank : 72)
Query Neighborhood Hits	54	Target Neighborhood Hits	442	Shared Neighborhood Hits	27
SwissProt Accessions	O75400, O43856, O75404, Q8TBQ1, Q9H782, Q9NWU9, Q9P0Q2, Q9Y5A8	Gene names	PRPF40A, FLAF1, FNBP3, HYPA
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein HYPA/FBP11) (Fas ligand-associated factor 1) (NY-REN-6 antigen).

PRP40_MOUSE
NC score	0.091606 (rank : 61)	θ value	θ > 10 (rank : 73)
Query Neighborhood Hits	54	Target Neighborhood Hits	447	Shared Neighborhood Hits	26
SwissProt Accessions	Q9R1C7, Q61049, Q8BQ76, Q8BRW4, Q8C2U1	Gene names	Prpf40a, Fbp11, Fnbp3
Domain Architecture
Description	Pre-mRNA-processing factor 40 homolog A (Formin-binding protein 3) (Formin-binding protein 11) (FBP-11).

DRP2_HUMAN
NC score	0.078995 (rank : 62)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	54	Target Neighborhood Hits	186	Shared Neighborhood Hits	22
SwissProt Accessions	Q13474	Gene names	DRP2
Domain Architecture
Description	Dystrophin-related protein 2.

SETD2_HUMAN
NC score	0.075424 (rank : 63)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	54	Target Neighborhood Hits	412	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BYW2, O75397, O75405, Q17RW8, Q5BKS9, Q5QGN2, Q69YI5, Q6IN64, Q6ZN53, Q6ZS25, Q8N3R0, Q8TCN0, Q9C0D1, Q9H696, Q9NZW9	Gene names	SETD2, HIF1, HYPB, KIAA1732, SET2
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-36-specific (EC 2.1.1.43) (SET domain-containing protein 2) (hSET2) (Huntingtin- interacting protein HYPB) (Huntingtin-interacting protein 1) (HIF-1) (p231HBP).

RHG12_MOUSE
NC score	0.068133 (rank : 64)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	54	Target Neighborhood Hits	204	Shared Neighborhood Hits	24
SwissProt Accessions	Q8C0D4, Q8BVP8	Gene names	Arhgap12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

WWC3_HUMAN
NC score	0.059776 (rank : 65)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	54	Target Neighborhood Hits	193	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ULE0, Q659C1, Q9BTQ1	Gene names	WWC3, KIAA1280
Domain Architecture	No domain graphic available
Description	WWC family member 3.

RHG12_HUMAN
NC score	0.057968 (rank : 66)	θ value	θ > 10 (rank : 74)
Query Neighborhood Hits	54	Target Neighborhood Hits	190	Shared Neighborhood Hits	20
SwissProt Accessions	Q8IWW6, Q86UB3, Q8IWW7, Q8N3L1, Q9NT76	Gene names	ARHGAP12
Domain Architecture
Description	Rho-GTPase-activating protein 12.

APBB2_HUMAN
NC score	0.057252 (rank : 67)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	54	Target Neighborhood Hits	96	Shared Neighborhood Hits	21
SwissProt Accessions	Q92870, Q8IUI6	Gene names	APBB2, FE65L, FE65L1
Domain Architecture	No domain graphic available
Description	Amyloid beta A4 precursor protein-binding family B member 2 (Fe65-like protein).

WBP4_MOUSE
NC score	0.056232 (rank : 68)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	54	Target Neighborhood Hits	100	Shared Neighborhood Hits	21
SwissProt Accessions	Q61048, Q8K1Z9, Q9CS45	Gene names	Wbp4, Fbp21, Fnbp21
Domain Architecture	No domain graphic available
Description	WW domain-binding protein 4 (WBP-4) (Formin-binding protein 21).

BTBDC_HUMAN
NC score	0.049062 (rank : 69)	θ value	1.38821 (rank : 42)
Query Neighborhood Hits	54	Target Neighborhood Hits	248	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IY92, Q96JP1	Gene names	BTBD12, KIAA1784
Domain Architecture	No domain graphic available
Description	BTB/POZ domain-containing protein 12.

DMD_HUMAN
NC score	0.045075 (rank : 70)	θ value	0.813845 (rank : 40)
Query Neighborhood Hits	54	Target Neighborhood Hits	1135	Shared Neighborhood Hits	29
SwissProt Accessions	P11532, Q02295, Q14169, Q14170, Q5JYU0, Q7KZ48	Gene names	DMD
Domain Architecture
Description	Dystrophin.

DMD_MOUSE
NC score	0.042302 (rank : 71)	θ value	0.813845 (rank : 41)
Query Neighborhood Hits	54	Target Neighborhood Hits	1111	Shared Neighborhood Hits	29
SwissProt Accessions	P11531, O35653, Q60703	Gene names	Dmd
Domain Architecture
Description	Dystrophin.

USF2_MOUSE
NC score	0.029898 (rank : 72)	θ value	3.0926 (rank : 45)
Query Neighborhood Hits	54	Target Neighborhood Hits	173	Shared Neighborhood Hits	4
SwissProt Accessions	Q64705, Q3UIL2, Q8VE59	Gene names	Usf2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (Major late transcription factor 2).

USF2_HUMAN
NC score	0.028958 (rank : 73)	θ value	4.03905 (rank : 47)
Query Neighborhood Hits	54	Target Neighborhood Hits	155	Shared Neighborhood Hits	4
SwissProt Accessions	Q15853, O00671, O00709, Q05750, Q07952, Q15851, Q15852	Gene names	USF2
Domain Architecture
Description	Upstream stimulatory factor 2 (Upstream transcription factor 2) (FOS- interacting protein) (FIP) (Major late transcription factor 2).

CIZ1_HUMAN
NC score	0.016654 (rank : 74)	θ value	5.27518 (rank : 49)
Query Neighborhood Hits	54	Target Neighborhood Hits	359	Shared Neighborhood Hits	3
SwissProt Accessions	Q9ULV3, Q9NYM8, Q9UHK4, Q9Y3F9, Q9Y3G0	Gene names	CIZ1, LSFR1, NP94
Domain Architecture	No domain graphic available
Description	Cip1-interacting zinc finger protein (Nuclear protein NP94).

GABR2_HUMAN
NC score	0.014648 (rank : 75)	θ value	4.03905 (rank : 46)
Query Neighborhood Hits	54	Target Neighborhood Hits	101	Shared Neighborhood Hits	2
SwissProt Accessions	O75899, O75974, O75975, Q5VXZ2, Q8WX04, Q9P1R2, Q9UNR1, Q9UNS9	Gene names	GABBR2, GPR51, GPRC3B
Domain Architecture
Description	Gamma-aminobutyric acid type B receptor, subunit 2 precursor (GABA-B receptor 2) (GABA-B-R2) (Gb2) (GABABR2) (G-protein coupled receptor 51) (HG20).

K0157_MOUSE
NC score	0.011495 (rank : 76)	θ value	8.99809 (rank : 53)
Query Neighborhood Hits	54	Target Neighborhood Hits	116	Shared Neighborhood Hits	2
SwissProt Accessions	Q3TCJ1, Q3TB08, Q8K0R4	Gene names	Kiaa0157
Domain Architecture	No domain graphic available
Description	Protein KIAA0157.

MYH7_HUMAN
NC score	0.008653 (rank : 77)	θ value	3.0926 (rank : 44)
Query Neighborhood Hits	54	Target Neighborhood Hits	1559	Shared Neighborhood Hits	13
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

ANKY1_HUMAN
NC score	0.008405 (rank : 78)	θ value	8.99809 (rank : 51)
Query Neighborhood Hits	54	Target Neighborhood Hits	248	Shared Neighborhood Hits	2
SwissProt Accessions	Q9P2S6, Q8IYX5, Q8NDK5, Q9NX10	Gene names	ANKMY1, TSAL1, ZMYND13
Domain Architecture
Description	Ankyrin repeat and MYND domain-containing protein 1 (Testis-specific ankyrin-like protein 1) (Zinc-finger MYND domain-containing protein 13).

TRPM6_MOUSE
NC score	0.006862 (rank : 79)	θ value	8.99809 (rank : 54)
Query Neighborhood Hits	54	Target Neighborhood Hits	78	Shared Neighborhood Hits	5
SwissProt Accessions	Q8CIR4	Gene names	Trpm6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6).

BRCA1_HUMAN
NC score	0.006082 (rank : 80)	θ value	8.99809 (rank : 52)
Query Neighborhood Hits	54	Target Neighborhood Hits	381	Shared Neighborhood Hits	2
SwissProt Accessions	P38398	Gene names	BRCA1, RNF53
Domain Architecture
Description	Breast cancer type 1 susceptibility protein (RING finger protein 53).

ADA29_HUMAN
NC score	0.004386 (rank : 81)	θ value	5.27518 (rank : 48)
Query Neighborhood Hits	54	Target Neighborhood Hits	247	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UKF5, Q9UHP1, Q9UKF3, Q9UKF4	Gene names	ADAM29
Domain Architecture
Description	ADAM 29 precursor (A disintegrin and metalloproteinase domain 29).

TLK2_MOUSE
NC score	0.003410 (rank : 82)	θ value	1.81305 (rank : 43)
Query Neighborhood Hits	54	Target Neighborhood Hits	1088	Shared Neighborhood Hits	4
SwissProt Accessions	O55047, Q9D5Y5	Gene names	Tlk2
Domain Architecture
Description	Serine/threonine-protein kinase tousled-like 2 (EC 2.7.11.1) (Tousled- like kinase 2).

INSR_MOUSE
NC score	-0.001131 (rank : 83)	θ value	5.27518 (rank : 50)
Query Neighborhood Hits	54	Target Neighborhood Hits	968	Shared Neighborhood Hits	2
SwissProt Accessions	P15208	Gene names	Insr
Domain Architecture
Description	Insulin receptor precursor (EC 2.7.10.1) (IR) (CD220 antigen) [Contains: Insulin receptor subunit alpha; Insulin receptor subunit beta].