Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : TOLIP_MOUSE

For an explanation of this page, click here

TOLIP_MOUSE
SwissProt Accessions	Q9QZ06, Q543N1, Q9D5P5	Gene names	Tollip
Domain Architecture
Description	Toll-interacting protein.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TOLIP_MOUSE
θ value	1.25199e-126 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	24	Target Neighborhood Hits	24	Shared Neighborhood Hits	24
SwissProt Accessions	Q9QZ06, Q543N1, Q9D5P5	Gene names	Tollip
Domain Architecture
Description	Toll-interacting protein.

TOLIP_HUMAN
θ value	3.52827e-121 (rank : 2)	NC score	0.994504 (rank : 2)
Query Neighborhood Hits	24	Target Neighborhood Hits	20	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H0E2, Q9H9E6, Q9UJ69	Gene names	TOLLIP
Domain Architecture
Description	Toll-interacting protein.

ITSN2_HUMAN
θ value	0.00175202 (rank : 3)	NC score	0.091184 (rank : 13)
Query Neighborhood Hits	24	Target Neighborhood Hits	1173	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	0.00390308 (rank : 4)	NC score	0.086308 (rank : 14)
Query Neighborhood Hits	24	Target Neighborhood Hits	1371	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

NED4L_MOUSE
θ value	0.00869519 (rank : 5)	NC score	0.130797 (rank : 7)
Query Neighborhood Hits	24	Target Neighborhood Hits	231	Shared Neighborhood Hits	18
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

CUED1_MOUSE
θ value	0.0113563 (rank : 6)	NC score	0.222234 (rank : 3)
Query Neighborhood Hits	24	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R3V6	Gene names	Cuedc1
Domain Architecture
Description	CUE domain-containing protein 1.

CUED1_HUMAN
θ value	0.0148317 (rank : 7)	NC score	0.221377 (rank : 4)
Query Neighborhood Hits	24	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NWM3, Q9NWD0	Gene names	CUEDC1
Domain Architecture
Description	CUE domain-containing protein 1.

ITCH_HUMAN
θ value	0.0193708 (rank : 8)	NC score	0.098696 (rank : 12)
Query Neighborhood Hits	24	Target Neighborhood Hits	162	Shared Neighborhood Hits	11
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

FA62A_MOUSE
θ value	0.0736092 (rank : 9)	NC score	0.151794 (rank : 5)
Query Neighborhood Hits	24	Target Neighborhood Hits	155	Shared Neighborhood Hits	20
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

RFIP1_MOUSE
θ value	0.0961366 (rank : 10)	NC score	0.109170 (rank : 10)
Query Neighborhood Hits	24	Target Neighborhood Hits	152	Shared Neighborhood Hits	10
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

RASA1_HUMAN
θ value	0.163984 (rank : 11)	NC score	0.056327 (rank : 49)
Query Neighborhood Hits	24	Target Neighborhood Hits	258	Shared Neighborhood Hits	7
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

FA62A_HUMAN
θ value	0.21417 (rank : 12)	NC score	0.141554 (rank : 6)
Query Neighborhood Hits	24	Target Neighborhood Hits	168	Shared Neighborhood Hits	19
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

SYT2_HUMAN
θ value	0.21417 (rank : 13)	NC score	0.079682 (rank : 18)
Query Neighborhood Hits	24	Target Neighborhood Hits	142	Shared Neighborhood Hits	16
SwissProt Accessions	Q8N9I0, Q496K5, Q8NBE5	Gene names	SYT2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT9_HUMAN
θ value	0.279714 (rank : 14)	NC score	0.085869 (rank : 15)
Query Neighborhood Hits	24	Target Neighborhood Hits	144	Shared Neighborhood Hits	16
SwissProt Accessions	Q86SS6	Gene names	SYT9
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX).

SYT9_MOUSE
θ value	0.279714 (rank : 15)	NC score	0.085364 (rank : 16)
Query Neighborhood Hits	24	Target Neighborhood Hits	148	Shared Neighborhood Hits	16
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

NEDD4_HUMAN
θ value	0.62314 (rank : 16)	NC score	0.110583 (rank : 9)
Query Neighborhood Hits	24	Target Neighborhood Hits	214	Shared Neighborhood Hits	18
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

NED4L_HUMAN
θ value	0.813845 (rank : 17)	NC score	0.114968 (rank : 8)
Query Neighborhood Hits	24	Target Neighborhood Hits	238	Shared Neighborhood Hits	18
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

ITCH_MOUSE
θ value	1.06291 (rank : 18)	NC score	0.084209 (rank : 17)
Query Neighborhood Hits	24	Target Neighborhood Hits	127	Shared Neighborhood Hits	12
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

NEDD4_MOUSE
θ value	1.06291 (rank : 19)	NC score	0.107694 (rank : 11)
Query Neighborhood Hits	24	Target Neighborhood Hits	212	Shared Neighborhood Hits	18
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

SYT2_MOUSE
θ value	1.06291 (rank : 20)	NC score	0.076528 (rank : 19)
Query Neighborhood Hits	24	Target Neighborhood Hits	143	Shared Neighborhood Hits	16
SwissProt Accessions	P46097, Q8R0E1	Gene names	Syt2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

PAR14_MOUSE
θ value	1.81305 (rank : 21)	NC score	0.032461 (rank : 68)
Query Neighborhood Hits	24	Target Neighborhood Hits	113	Shared Neighborhood Hits	3
SwissProt Accessions	Q2EMV9, Q571C6, Q8BN35, Q8VDT6	Gene names	Parp14, Kiaa1268
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 14 (EC 2.4.2.30) (PARP-14) (Collaborator of STAT6) (CoaSt6).

SYT1_HUMAN
θ value	5.27518 (rank : 22)	NC score	0.071782 (rank : 20)
Query Neighborhood Hits	24	Target Neighborhood Hits	150	Shared Neighborhood Hits	16
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
θ value	5.27518 (rank : 23)	NC score	0.071767 (rank : 21)
Query Neighborhood Hits	24	Target Neighborhood Hits	150	Shared Neighborhood Hits	16
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

UCP1_MOUSE
θ value	8.99809 (rank : 24)	NC score	0.007546 (rank : 69)
Query Neighborhood Hits	24	Target Neighborhood Hits	66	Shared Neighborhood Hits	2
SwissProt Accessions	P12242	Gene names	Ucp1, Ucp
Domain Architecture
Description	Mitochondrial brown fat uncoupling protein 1 (UCP 1) (Thermogenin).

DOC2A_HUMAN
θ value	θ > 10 (rank : 25)	NC score	0.055828 (rank : 51)
Query Neighborhood Hits	24	Target Neighborhood Hits	144	Shared Neighborhood Hits	15
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

DOC2A_MOUSE
θ value	θ > 10 (rank : 26)	NC score	0.055955 (rank : 50)
Query Neighborhood Hits	24	Target Neighborhood Hits	140	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

DOC2B_HUMAN
θ value	θ > 10 (rank : 27)	NC score	0.056908 (rank : 45)
Query Neighborhood Hits	24	Target Neighborhood Hits	150	Shared Neighborhood Hits	15
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2B_MOUSE
θ value	θ > 10 (rank : 28)	NC score	0.056984 (rank : 44)
Query Neighborhood Hits	24	Target Neighborhood Hits	169	Shared Neighborhood Hits	15
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2G_MOUSE
θ value	θ > 10 (rank : 29)	NC score	0.054247 (rank : 54)
Query Neighborhood Hits	24	Target Neighborhood Hits	125	Shared Neighborhood Hits	14
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

HECD2_HUMAN
θ value	θ > 10 (rank : 30)	NC score	0.055280 (rank : 53)
Query Neighborhood Hits	24	Target Neighborhood Hits	41	Shared Neighborhood Hits	6
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_MOUSE
θ value	θ > 10 (rank : 31)	NC score	0.055421 (rank : 52)
Query Neighborhood Hits	24	Target Neighborhood Hits	38	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HUWE1_HUMAN
θ value	θ > 10 (rank : 32)	NC score	0.056621 (rank : 48)
Query Neighborhood Hits	24	Target Neighborhood Hits	443	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

HUWE1_MOUSE
θ value	θ > 10 (rank : 33)	NC score	0.056729 (rank : 47)
Query Neighborhood Hits	24	Target Neighborhood Hits	406	Shared Neighborhood Hits	6
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

ITSN1_MOUSE
θ value	θ > 10 (rank : 34)	NC score	0.050028 (rank : 67)
Query Neighborhood Hits	24	Target Neighborhood Hits	1669	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

K0317_HUMAN
θ value	θ > 10 (rank : 35)	NC score	0.060177 (rank : 43)
Query Neighborhood Hits	24	Target Neighborhood Hits	46	Shared Neighborhood Hits	6
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_MOUSE
θ value	θ > 10 (rank : 36)	NC score	0.060238 (rank : 42)
Query Neighborhood Hits	24	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

RASL1_HUMAN
θ value	θ > 10 (rank : 37)	NC score	0.060360 (rank : 41)
Query Neighborhood Hits	24	Target Neighborhood Hits	142	Shared Neighborhood Hits	16
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL1_MOUSE
θ value	θ > 10 (rank : 38)	NC score	0.056787 (rank : 46)
Query Neighborhood Hits	24	Target Neighborhood Hits	148	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

RASL2_HUMAN
θ value	θ > 10 (rank : 39)	NC score	0.064984 (rank : 34)
Query Neighborhood Hits	24	Target Neighborhood Hits	161	Shared Neighborhood Hits	16
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

RFIP2_HUMAN
θ value	θ > 10 (rank : 40)	NC score	0.063226 (rank : 37)
Query Neighborhood Hits	24	Target Neighborhood Hits	97	Shared Neighborhood Hits	15
SwissProt Accessions	Q7L804, Q9Y2F0	Gene names	RAB11FIP2, KIAA0941
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11).

RP3A_HUMAN
θ value	θ > 10 (rank : 41)	NC score	0.053389 (rank : 63)
Query Neighborhood Hits	24	Target Neighborhood Hits	305	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

RP3A_MOUSE
θ value	θ > 10 (rank : 42)	NC score	0.053585 (rank : 61)
Query Neighborhood Hits	24	Target Neighborhood Hits	510	Shared Neighborhood Hits	15
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SMUF1_HUMAN
θ value	θ > 10 (rank : 43)	NC score	0.070447 (rank : 23)
Query Neighborhood Hits	24	Target Neighborhood Hits	135	Shared Neighborhood Hits	14
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
θ value	θ > 10 (rank : 44)	NC score	0.070084 (rank : 24)
Query Neighborhood Hits	24	Target Neighborhood Hits	142	Shared Neighborhood Hits	14
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

SMUF2_HUMAN
θ value	θ > 10 (rank : 45)	NC score	0.071391 (rank : 22)
Query Neighborhood Hits	24	Target Neighborhood Hits	142	Shared Neighborhood Hits	14
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SYT10_HUMAN
θ value	θ > 10 (rank : 46)	NC score	0.062615 (rank : 39)
Query Neighborhood Hits	24	Target Neighborhood Hits	134	Shared Neighborhood Hits	14
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT10_MOUSE
θ value	θ > 10 (rank : 47)	NC score	0.064179 (rank : 35)
Query Neighborhood Hits	24	Target Neighborhood Hits	133	Shared Neighborhood Hits	14
SwissProt Accessions	Q9R0N4	Gene names	Syt10
Domain Architecture
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT11_HUMAN
θ value	θ > 10 (rank : 48)	NC score	0.053927 (rank : 55)
Query Neighborhood Hits	24	Target Neighborhood Hits	113	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BT88, Q14998, Q68CT5, Q8IXU3, Q96SU2	Gene names	SYT11, KIAA0080
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT11_MOUSE
θ value	θ > 10 (rank : 49)	NC score	0.053799 (rank : 57)
Query Neighborhood Hits	24	Target Neighborhood Hits	116	Shared Neighborhood Hits	15
SwissProt Accessions	Q9R0N3	Gene names	Syt11
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

SYT15_HUMAN
θ value	θ > 10 (rank : 50)	NC score	0.051696 (rank : 65)
Query Neighborhood Hits	24	Target Neighborhood Hits	112	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BQS2, Q7Z439, Q7Z440	Gene names	SYT15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV) (Chr10Syt).

SYT3_HUMAN
θ value	θ > 10 (rank : 51)	NC score	0.066077 (rank : 31)
Query Neighborhood Hits	24	Target Neighborhood Hits	145	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BQG1, Q8N5Z1, Q8N640	Gene names	SYT3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT3_MOUSE
θ value	θ > 10 (rank : 52)	NC score	0.066380 (rank : 30)
Query Neighborhood Hits	24	Target Neighborhood Hits	147	Shared Neighborhood Hits	15
SwissProt Accessions	O35681, P97791, Q80WV1	Gene names	Syt3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT4_HUMAN
θ value	θ > 10 (rank : 53)	NC score	0.053689 (rank : 60)
Query Neighborhood Hits	24	Target Neighborhood Hits	121	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H2B2, Q9P2K4	Gene names	SYT4, KIAA1342
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

SYT4_MOUSE
θ value	θ > 10 (rank : 54)	NC score	0.053509 (rank : 62)
Query Neighborhood Hits	24	Target Neighborhood Hits	123	Shared Neighborhood Hits	14
SwissProt Accessions	P40749, Q3UFC1, Q8BGH3, Q8BRL6	Gene names	Syt4, Syt3
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

SYT5_HUMAN
θ value	θ > 10 (rank : 55)	NC score	0.067499 (rank : 28)
Query Neighborhood Hits	24	Target Neighborhood Hits	138	Shared Neighborhood Hits	15
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

SYT5_MOUSE
θ value	θ > 10 (rank : 56)	NC score	0.063751 (rank : 36)
Query Neighborhood Hits	24	Target Neighborhood Hits	140	Shared Neighborhood Hits	15
SwissProt Accessions	Q9R0N5	Gene names	Syt5, Syt9
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV) (Synaptotagmin IX).

SYT6_HUMAN
θ value	θ > 10 (rank : 57)	NC score	0.062703 (rank : 38)
Query Neighborhood Hits	24	Target Neighborhood Hits	138	Shared Neighborhood Hits	14
SwissProt Accessions	Q5T7P8	Gene names	SYT6
Domain Architecture	No domain graphic available
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT6_MOUSE
θ value	θ > 10 (rank : 58)	NC score	0.062155 (rank : 40)
Query Neighborhood Hits	24	Target Neighborhood Hits	132	Shared Neighborhood Hits	14
SwissProt Accessions	Q9R0N8	Gene names	Syt6
Domain Architecture
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT7_HUMAN
θ value	θ > 10 (rank : 59)	NC score	0.065347 (rank : 32)
Query Neighborhood Hits	24	Target Neighborhood Hits	137	Shared Neighborhood Hits	16
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT7_MOUSE
θ value	θ > 10 (rank : 60)	NC score	0.065082 (rank : 33)
Query Neighborhood Hits	24	Target Neighborhood Hits	137	Shared Neighborhood Hits	16
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

UBE3A_HUMAN
θ value	θ > 10 (rank : 61)	NC score	0.053902 (rank : 56)
Query Neighborhood Hits	24	Target Neighborhood Hits	49	Shared Neighborhood Hits	6
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

UBE3A_MOUSE
θ value	θ > 10 (rank : 62)	NC score	0.053370 (rank : 64)
Query Neighborhood Hits	24	Target Neighborhood Hits	47	Shared Neighborhood Hits	6
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

UBE3C_HUMAN
θ value	θ > 10 (rank : 63)	NC score	0.053782 (rank : 58)
Query Neighborhood Hits	24	Target Neighborhood Hits	51	Shared Neighborhood Hits	6
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
θ value	θ > 10 (rank : 64)	NC score	0.053706 (rank : 59)
Query Neighborhood Hits	24	Target Neighborhood Hits	48	Shared Neighborhood Hits	6
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UN13D_HUMAN
θ value	θ > 10 (rank : 65)	NC score	0.050243 (rank : 66)
Query Neighborhood Hits	24	Target Neighborhood Hits	117	Shared Neighborhood Hits	15
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

WWP1_HUMAN
θ value	θ > 10 (rank : 66)	NC score	0.070050 (rank : 25)
Query Neighborhood Hits	24	Target Neighborhood Hits	262	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

WWP1_MOUSE
θ value	θ > 10 (rank : 67)	NC score	0.069350 (rank : 26)
Query Neighborhood Hits	24	Target Neighborhood Hits	138	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

WWP2_HUMAN
θ value	θ > 10 (rank : 68)	NC score	0.067436 (rank : 29)
Query Neighborhood Hits	24	Target Neighborhood Hits	177	Shared Neighborhood Hits	6
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

WWP2_MOUSE
θ value	θ > 10 (rank : 69)	NC score	0.067632 (rank : 27)
Query Neighborhood Hits	24	Target Neighborhood Hits	118	Shared Neighborhood Hits	6
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

Hits sorted by NC score

TOLIP_MOUSE
NC score	0.999962 (rank : 1)	θ value	1.25199e-126 (rank : 1)
Query Neighborhood Hits	24	Target Neighborhood Hits	24	Shared Neighborhood Hits	24
SwissProt Accessions	Q9QZ06, Q543N1, Q9D5P5	Gene names	Tollip
Domain Architecture
Description	Toll-interacting protein.

TOLIP_HUMAN
NC score	0.994504 (rank : 2)	θ value	3.52827e-121 (rank : 2)
Query Neighborhood Hits	24	Target Neighborhood Hits	20	Shared Neighborhood Hits	19
SwissProt Accessions	Q9H0E2, Q9H9E6, Q9UJ69	Gene names	TOLLIP
Domain Architecture
Description	Toll-interacting protein.

CUED1_MOUSE
NC score	0.222234 (rank : 3)	θ value	0.0113563 (rank : 6)
Query Neighborhood Hits	24	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R3V6	Gene names	Cuedc1
Domain Architecture
Description	CUE domain-containing protein 1.

CUED1_HUMAN
NC score	0.221377 (rank : 4)	θ value	0.0148317 (rank : 7)
Query Neighborhood Hits	24	Target Neighborhood Hits	21	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NWM3, Q9NWD0	Gene names	CUEDC1
Domain Architecture
Description	CUE domain-containing protein 1.

FA62A_MOUSE
NC score	0.151794 (rank : 5)	θ value	0.0736092 (rank : 9)
Query Neighborhood Hits	24	Target Neighborhood Hits	155	Shared Neighborhood Hits	20
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

FA62A_HUMAN
NC score	0.141554 (rank : 6)	θ value	0.21417 (rank : 12)
Query Neighborhood Hits	24	Target Neighborhood Hits	168	Shared Neighborhood Hits	19
SwissProt Accessions	Q9BSJ8, O94848, Q6PJN4, Q9H6J1, Q9H6W2, Q9Y416	Gene names	FAM62A, KIAA0747, MBC2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

NED4L_MOUSE
NC score	0.130797 (rank : 7)	θ value	0.00869519 (rank : 5)
Query Neighborhood Hits	24	Target Neighborhood Hits	231	Shared Neighborhood Hits	18
SwissProt Accessions	Q8CFI0, Q8BRT9, Q8BS42, Q99PK2	Gene names	Nedd4l, Kiaa0439, Nedd4b
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NED4L_HUMAN
NC score	0.114968 (rank : 8)	θ value	0.813845 (rank : 17)
Query Neighborhood Hits	24	Target Neighborhood Hits	238	Shared Neighborhood Hits	18
SwissProt Accessions	Q96PU5, O43165, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q9BW58, Q9H2W4, Q9NT88	Gene names	NEDD4L, KIAA0439, NEDL3
Domain Architecture	No domain graphic available
Description	E3 ubiquitin-protein ligase NEDD4-like protein (EC 6.3.2.-) (Nedd4-2) (NEDD4.2).

NEDD4_HUMAN
NC score	0.110583 (rank : 9)	θ value	0.62314 (rank : 16)
Query Neighborhood Hits	24	Target Neighborhood Hits	214	Shared Neighborhood Hits	18
SwissProt Accessions	P46934	Gene names	NEDD4, KIAA0093
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-).

RFIP1_MOUSE
NC score	0.109170 (rank : 10)	θ value	0.0961366 (rank : 10)
Query Neighborhood Hits	24	Target Neighborhood Hits	152	Shared Neighborhood Hits	10
SwissProt Accessions	Q9D620, Q3UBC2, Q8BN24	Gene names	Rab11fip1, Rcp
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein).

NEDD4_MOUSE
NC score	0.107694 (rank : 11)	θ value	1.06291 (rank : 19)
Query Neighborhood Hits	24	Target Neighborhood Hits	212	Shared Neighborhood Hits	18
SwissProt Accessions	P46935, O08758, Q3UZI2, Q8BGB3	Gene names	Nedd4, Kiaa0093, Nedd-4, Nedd4a
Domain Architecture
Description	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-) (Neural precursor cell expressed developmentally down-regulated protein 4).

ITCH_HUMAN
NC score	0.098696 (rank : 12)	θ value	0.0193708 (rank : 8)
Query Neighborhood Hits	24	Target Neighborhood Hits	162	Shared Neighborhood Hits	11
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

ITSN2_HUMAN
NC score	0.091184 (rank : 13)	θ value	0.00175202 (rank : 3)
Query Neighborhood Hits	24	Target Neighborhood Hits	1173	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
NC score	0.086308 (rank : 14)	θ value	0.00390308 (rank : 4)
Query Neighborhood Hits	24	Target Neighborhood Hits	1371	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

SYT9_HUMAN
NC score	0.085869 (rank : 15)	θ value	0.279714 (rank : 14)
Query Neighborhood Hits	24	Target Neighborhood Hits	144	Shared Neighborhood Hits	16
SwissProt Accessions	Q86SS6	Gene names	SYT9
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX).

SYT9_MOUSE
NC score	0.085364 (rank : 16)	θ value	0.279714 (rank : 15)
Query Neighborhood Hits	24	Target Neighborhood Hits	148	Shared Neighborhood Hits	16
SwissProt Accessions	Q9R0N9, Q8C280	Gene names	Syt9, Syt5
Domain Architecture
Description	Synaptotagmin-9 (Synaptotagmin IX) (SytIX) (Synaptotagmin V).

ITCH_MOUSE
NC score	0.084209 (rank : 17)	θ value	1.06291 (rank : 18)
Query Neighborhood Hits	24	Target Neighborhood Hits	127	Shared Neighborhood Hits	12
SwissProt Accessions	Q8C863, O54971	Gene names	Itch
Domain Architecture
Description	Itchy E3 ubiquitin protein ligase (EC 6.3.2.-).

SYT2_HUMAN
NC score	0.079682 (rank : 18)	θ value	0.21417 (rank : 13)
Query Neighborhood Hits	24	Target Neighborhood Hits	142	Shared Neighborhood Hits	16
SwissProt Accessions	Q8N9I0, Q496K5, Q8NBE5	Gene names	SYT2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT2_MOUSE
NC score	0.076528 (rank : 19)	θ value	1.06291 (rank : 20)
Query Neighborhood Hits	24	Target Neighborhood Hits	143	Shared Neighborhood Hits	16
SwissProt Accessions	P46097, Q8R0E1	Gene names	Syt2
Domain Architecture
Description	Synaptotagmin-2 (Synaptotagmin II) (SytII).

SYT1_HUMAN
NC score	0.071782 (rank : 20)	θ value	5.27518 (rank : 22)
Query Neighborhood Hits	24	Target Neighborhood Hits	150	Shared Neighborhood Hits	16
SwissProt Accessions	P21579	Gene names	SYT1, SYT
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SYT1_MOUSE
NC score	0.071767 (rank : 21)	θ value	5.27518 (rank : 23)
Query Neighborhood Hits	24	Target Neighborhood Hits	150	Shared Neighborhood Hits	16
SwissProt Accessions	P46096	Gene names	Syt1
Domain Architecture
Description	Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65).

SMUF2_HUMAN
NC score	0.071391 (rank : 22)	θ value	θ > 10 (rank : 45)
Query Neighborhood Hits	24	Target Neighborhood Hits	142	Shared Neighborhood Hits	14
SwissProt Accessions	Q9HAU4, Q9H260	Gene names	SMURF2
Domain Architecture
Description	Smad ubiquitination regulatory factor 2 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF2) (Smad-specific E3 ubiquitin ligase 2) (hSMURF2).

SMUF1_HUMAN
NC score	0.070447 (rank : 23)	θ value	θ > 10 (rank : 43)
Query Neighborhood Hits	24	Target Neighborhood Hits	135	Shared Neighborhood Hits	14
SwissProt Accessions	Q9HCE7, O75853, Q9UJT8	Gene names	SMURF1, KIAA1625
Domain Architecture
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1) (hSMURF1).

SMUF1_MOUSE
NC score	0.070084 (rank : 24)	θ value	θ > 10 (rank : 44)
Query Neighborhood Hits	24	Target Neighborhood Hits	142	Shared Neighborhood Hits	14
SwissProt Accessions	Q9CUN6, Q3U412, Q8K300	Gene names	Smurf1
Domain Architecture	No domain graphic available
Description	Smad ubiquitination regulatory factor 1 (EC 6.3.2.-) (Ubiquitin-- protein ligase SMURF1) (Smad-specific E3 ubiquitin ligase 1).

WWP1_HUMAN
NC score	0.070050 (rank : 25)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	24	Target Neighborhood Hits	262	Shared Neighborhood Hits	9
SwissProt Accessions	Q9H0M0, O00307, Q96BP4	Gene names	WWP1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1) (Atropin-1-interacting protein 5) (AIP5).

WWP1_MOUSE
NC score	0.069350 (rank : 26)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	24	Target Neighborhood Hits	138	Shared Neighborhood Hits	8
SwissProt Accessions	Q8BZZ3, Q8BIV9, Q8VDP8	Gene names	Wwp1
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC 6.3.2.-) (WW domain- containing protein 1).

WWP2_MOUSE
NC score	0.067632 (rank : 27)	θ value	θ > 10 (rank : 69)
Query Neighborhood Hits	24	Target Neighborhood Hits	118	Shared Neighborhood Hits	6
SwissProt Accessions	Q9DBH0, Q8BTG4, Q923F6	Gene names	Wwp2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2).

SYT5_HUMAN
NC score	0.067499 (rank : 28)	θ value	θ > 10 (rank : 55)
Query Neighborhood Hits	24	Target Neighborhood Hits	138	Shared Neighborhood Hits	15
SwissProt Accessions	O00445, Q86X72	Gene names	SYT5
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV).

WWP2_HUMAN
NC score	0.067436 (rank : 29)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	24	Target Neighborhood Hits	177	Shared Neighborhood Hits	6
SwissProt Accessions	O00308, Q96CZ2, Q9BWN6	Gene names	WWP2
Domain Architecture
Description	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) (WW domain- containing protein 2) (Atrophin-1-interacting protein 2) (AIP2).

SYT3_MOUSE
NC score	0.066380 (rank : 30)	θ value	θ > 10 (rank : 52)
Query Neighborhood Hits	24	Target Neighborhood Hits	147	Shared Neighborhood Hits	15
SwissProt Accessions	O35681, P97791, Q80WV1	Gene names	Syt3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT3_HUMAN
NC score	0.066077 (rank : 31)	θ value	θ > 10 (rank : 51)
Query Neighborhood Hits	24	Target Neighborhood Hits	145	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BQG1, Q8N5Z1, Q8N640	Gene names	SYT3
Domain Architecture
Description	Synaptotagmin-3 (Synaptotagmin III) (SytIII).

SYT7_HUMAN
NC score	0.065347 (rank : 32)	θ value	θ > 10 (rank : 59)
Query Neighborhood Hits	24	Target Neighborhood Hits	137	Shared Neighborhood Hits	16
SwissProt Accessions	O43581	Gene names	SYT7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

SYT7_MOUSE
NC score	0.065082 (rank : 33)	θ value	θ > 10 (rank : 60)
Query Neighborhood Hits	24	Target Neighborhood Hits	137	Shared Neighborhood Hits	16
SwissProt Accessions	Q9R0N7	Gene names	Syt7
Domain Architecture
Description	Synaptotagmin-7 (Synaptotagmin VII) (SytVII).

RASL2_HUMAN
NC score	0.064984 (rank : 34)	θ value	θ > 10 (rank : 39)
Query Neighborhood Hits	24	Target Neighborhood Hits	161	Shared Neighborhood Hits	16
SwissProt Accessions	O43374, O60286, Q86UW3, Q96QU0	Gene names	RASA4, CAPRI, GAPL, KIAA0538
Domain Architecture
Description	Ras GTPase-activating protein 4 (RasGAP-activating-like protein 2) (Calcium-promoted Ras inactivator).

SYT10_MOUSE
NC score	0.064179 (rank : 35)	θ value	θ > 10 (rank : 47)
Query Neighborhood Hits	24	Target Neighborhood Hits	133	Shared Neighborhood Hits	14
SwissProt Accessions	Q9R0N4	Gene names	Syt10
Domain Architecture
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT5_MOUSE
NC score	0.063751 (rank : 36)	θ value	θ > 10 (rank : 56)
Query Neighborhood Hits	24	Target Neighborhood Hits	140	Shared Neighborhood Hits	15
SwissProt Accessions	Q9R0N5	Gene names	Syt5, Syt9
Domain Architecture
Description	Synaptotagmin-5 (Synaptotagmin V) (SytV) (Synaptotagmin IX).

RFIP2_HUMAN
NC score	0.063226 (rank : 37)	θ value	θ > 10 (rank : 40)
Query Neighborhood Hits	24	Target Neighborhood Hits	97	Shared Neighborhood Hits	15
SwissProt Accessions	Q7L804, Q9Y2F0	Gene names	RAB11FIP2, KIAA0941
Domain Architecture	No domain graphic available
Description	Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11).

SYT6_HUMAN
NC score	0.062703 (rank : 38)	θ value	θ > 10 (rank : 57)
Query Neighborhood Hits	24	Target Neighborhood Hits	138	Shared Neighborhood Hits	14
SwissProt Accessions	Q5T7P8	Gene names	SYT6
Domain Architecture	No domain graphic available
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

SYT10_HUMAN
NC score	0.062615 (rank : 39)	θ value	θ > 10 (rank : 46)
Query Neighborhood Hits	24	Target Neighborhood Hits	134	Shared Neighborhood Hits	14
SwissProt Accessions	Q6XYQ8	Gene names	SYT10
Domain Architecture	No domain graphic available
Description	Synaptotagmin-10 (Synaptotagmin X) (SytX).

SYT6_MOUSE
NC score	0.062155 (rank : 40)	θ value	θ > 10 (rank : 58)
Query Neighborhood Hits	24	Target Neighborhood Hits	132	Shared Neighborhood Hits	14
SwissProt Accessions	Q9R0N8	Gene names	Syt6
Domain Architecture
Description	Synaptotagmin-6 (Synaptotagmin VI) (SytVI).

RASL1_HUMAN
NC score	0.060360 (rank : 41)	θ value	θ > 10 (rank : 37)
Query Neighborhood Hits	24	Target Neighborhood Hits	142	Shared Neighborhood Hits	16
SwissProt Accessions	O95294, Q52M03, Q96CC7	Gene names	RASAL1, RASAL
Domain Architecture
Description	RasGAP-activating-like protein 1.

K0317_MOUSE
NC score	0.060238 (rank : 42)	θ value	θ > 10 (rank : 36)
Query Neighborhood Hits	24	Target Neighborhood Hits	43	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CHG5, Q6P9Q1, Q80YC4, Q8C5W5	Gene names	Kiaa0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

K0317_HUMAN
NC score	0.060177 (rank : 43)	θ value	θ > 10 (rank : 35)
Query Neighborhood Hits	24	Target Neighborhood Hits	46	Shared Neighborhood Hits	6
SwissProt Accessions	O15033, Q7LDY1, Q8IYY9	Gene names	KIAA0317
Domain Architecture	No domain graphic available
Description	Protein KIAA0317.

DOC2B_MOUSE
NC score	0.056984 (rank : 44)	θ value	θ > 10 (rank : 28)
Query Neighborhood Hits	24	Target Neighborhood Hits	169	Shared Neighborhood Hits	15
SwissProt Accessions	P70169, Q6NXK3	Gene names	Doc2b
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

DOC2B_HUMAN
NC score	0.056908 (rank : 45)	θ value	θ > 10 (rank : 27)
Query Neighborhood Hits	24	Target Neighborhood Hits	150	Shared Neighborhood Hits	15
SwissProt Accessions	Q14184	Gene names	DOC2B
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein beta (Doc2-beta).

RASL1_MOUSE
NC score	0.056787 (rank : 46)	θ value	θ > 10 (rank : 38)
Query Neighborhood Hits	24	Target Neighborhood Hits	148	Shared Neighborhood Hits	16
SwissProt Accessions	Q9Z268	Gene names	Rasal1, Rasal
Domain Architecture
Description	RasGAP-activating-like protein 1.

HUWE1_MOUSE
NC score	0.056729 (rank : 47)	θ value	θ > 10 (rank : 33)
Query Neighborhood Hits	24	Target Neighborhood Hits	406	Shared Neighborhood Hits	6
SwissProt Accessions	Q7TMY8, Q4G2Z1, Q5BMM7, Q6NS61, Q8BNJ7, Q8CFH2, Q8VD14, Q921M5, Q9R0P2	Gene names	Huwe1, Kiaa0312, Ureb1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (E3Histone).

HUWE1_HUMAN
NC score	0.056621 (rank : 48)	θ value	θ > 10 (rank : 32)
Query Neighborhood Hits	24	Target Neighborhood Hits	443	Shared Neighborhood Hits	6
SwissProt Accessions	Q7Z6Z7, O15029, Q4G2Z2, Q5H961, Q6P4D0, Q8NG67, Q9BUI0, Q9HCJ4, Q9NSL6, Q9P0A9	Gene names	HUWE1, KIAA0312, KIAA1578, UREB1
Domain Architecture	No domain graphic available
Description	HECT, UBA and WWE domain-containing protein 1 (EC 6.3.2.-) (E3 ubiquitin protein ligase URE-B1) (Mcl-1 ubiquitin ligase E3) (Mule) (ARF-binding protein 1) (ARF-BP1).

RASA1_HUMAN
NC score	0.056327 (rank : 49)	θ value	0.163984 (rank : 11)
Query Neighborhood Hits	24	Target Neighborhood Hits	258	Shared Neighborhood Hits	7
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

DOC2A_MOUSE
NC score	0.055955 (rank : 50)	θ value	θ > 10 (rank : 26)
Query Neighborhood Hits	24	Target Neighborhood Hits	140	Shared Neighborhood Hits	15
SwissProt Accessions	Q7TNF0	Gene names	Doc2a
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha).

DOC2A_HUMAN
NC score	0.055828 (rank : 51)	θ value	θ > 10 (rank : 25)
Query Neighborhood Hits	24	Target Neighborhood Hits	144	Shared Neighborhood Hits	15
SwissProt Accessions	Q14183, Q6P4G4, Q7Z5G0, Q8IVX0	Gene names	DOC2A
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein alpha (Doc2-alpha) (Doc2).

HECD2_MOUSE
NC score	0.055421 (rank : 52)	θ value	θ > 10 (rank : 31)
Query Neighborhood Hits	24	Target Neighborhood Hits	38	Shared Neighborhood Hits	6
SwissProt Accessions	Q8CDU6, Q8CBQ9	Gene names	Hectd2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

HECD2_HUMAN
NC score	0.055280 (rank : 53)	θ value	θ > 10 (rank : 30)
Query Neighborhood Hits	24	Target Neighborhood Hits	41	Shared Neighborhood Hits	6
SwissProt Accessions	Q5U5R9, Q5VZ97, Q5VZ99, Q8TCP5	Gene names	HECTD2
Domain Architecture	No domain graphic available
Description	Probable E3 ubiquitin-protein ligase HECTD2 (HECT domain-containing protein 2).

DOC2G_MOUSE
NC score	0.054247 (rank : 54)	θ value	θ > 10 (rank : 29)
Query Neighborhood Hits	24	Target Neighborhood Hits	125	Shared Neighborhood Hits	14
SwissProt Accessions	Q9ESN1, Q6P8R8	Gene names	Doc2g
Domain Architecture	No domain graphic available
Description	Double C2-like domain-containing protein gamma (Doc2-gamma).

SYT11_HUMAN
NC score	0.053927 (rank : 55)	θ value	θ > 10 (rank : 48)
Query Neighborhood Hits	24	Target Neighborhood Hits	113	Shared Neighborhood Hits	15
SwissProt Accessions	Q9BT88, Q14998, Q68CT5, Q8IXU3, Q96SU2	Gene names	SYT11, KIAA0080
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

UBE3A_HUMAN
NC score	0.053902 (rank : 56)	θ value	θ > 10 (rank : 61)
Query Neighborhood Hits	24	Target Neighborhood Hits	49	Shared Neighborhood Hits	6
SwissProt Accessions	Q05086, P78355, Q93066, Q9UEP4, Q9UEP5, Q9UEP6, Q9UEP7, Q9UEP8, Q9UEP9	Gene names	UBE3A, E6AP
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (E6AP ubiquitin-protein ligase) (Oncogenic protein-associated protein E6-AP) (Human papillomavirus E6-associated protein) (NY-REN-54 antigen).

SYT11_MOUSE
NC score	0.053799 (rank : 57)	θ value	θ > 10 (rank : 49)
Query Neighborhood Hits	24	Target Neighborhood Hits	116	Shared Neighborhood Hits	15
SwissProt Accessions	Q9R0N3	Gene names	Syt11
Domain Architecture
Description	Synaptotagmin-11 (Synaptotagmin XI) (SytXI).

UBE3C_HUMAN
NC score	0.053782 (rank : 58)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	24	Target Neighborhood Hits	51	Shared Neighborhood Hits	6
SwissProt Accessions	Q15386, Q8TC15, Q96CR4, Q9UDU3	Gene names	UBE3C, KIAA0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

UBE3C_MOUSE
NC score	0.053706 (rank : 59)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	24	Target Neighborhood Hits	48	Shared Neighborhood Hits	6
SwissProt Accessions	Q80U95, Q8BQZ6, Q8C7W6, Q8CDJ1, Q8VDL5	Gene names	Ube3c, Kiaa0010
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase E3C (EC 6.3.2.-).

SYT4_HUMAN
NC score	0.053689 (rank : 60)	θ value	θ > 10 (rank : 53)
Query Neighborhood Hits	24	Target Neighborhood Hits	121	Shared Neighborhood Hits	14
SwissProt Accessions	Q9H2B2, Q9P2K4	Gene names	SYT4, KIAA1342
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

RP3A_MOUSE
NC score	0.053585 (rank : 61)	θ value	θ > 10 (rank : 42)
Query Neighborhood Hits	24	Target Neighborhood Hits	510	Shared Neighborhood Hits	15
SwissProt Accessions	P47708	Gene names	Rph3a
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

SYT4_MOUSE
NC score	0.053509 (rank : 62)	θ value	θ > 10 (rank : 54)
Query Neighborhood Hits	24	Target Neighborhood Hits	123	Shared Neighborhood Hits	14
SwissProt Accessions	P40749, Q3UFC1, Q8BGH3, Q8BRL6	Gene names	Syt4, Syt3
Domain Architecture
Description	Synaptotagmin-4 (Synaptotagmin IV) (SytIV).

RP3A_HUMAN
NC score	0.053389 (rank : 63)	θ value	θ > 10 (rank : 41)
Query Neighborhood Hits	24	Target Neighborhood Hits	305	Shared Neighborhood Hits	15
SwissProt Accessions	Q9Y2J0, Q96AE0	Gene names	RPH3A, KIAA0985
Domain Architecture
Description	Rabphilin-3A (Exophilin-1).

UBE3A_MOUSE
NC score	0.053370 (rank : 64)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	24	Target Neighborhood Hits	47	Shared Neighborhood Hits	6
SwissProt Accessions	O08759, P97482	Gene names	Ube3a
Domain Architecture
Description	Ubiquitin-protein ligase E3A (EC 6.3.2.-) (Oncogenic protein- associated protein E6-AP).

SYT15_HUMAN
NC score	0.051696 (rank : 65)	θ value	θ > 10 (rank : 50)
Query Neighborhood Hits	24	Target Neighborhood Hits	112	Shared Neighborhood Hits	12
SwissProt Accessions	Q9BQS2, Q7Z439, Q7Z440	Gene names	SYT15
Domain Architecture
Description	Synaptotagmin-15 (Synaptotagmin XV) (SytXV) (Chr10Syt).

UN13D_HUMAN
NC score	0.050243 (rank : 66)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	24	Target Neighborhood Hits	117	Shared Neighborhood Hits	15
SwissProt Accessions	Q70J99, Q9H7K5	Gene names	UNC13D
Domain Architecture	No domain graphic available
Description	Unc-13 homolog D (Munc13-4).

ITSN1_MOUSE
NC score	0.050028 (rank : 67)	θ value	θ > 10 (rank : 34)
Query Neighborhood Hits	24	Target Neighborhood Hits	1669	Shared Neighborhood Hits	17
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

PAR14_MOUSE
NC score	0.032461 (rank : 68)	θ value	1.81305 (rank : 21)
Query Neighborhood Hits	24	Target Neighborhood Hits	113	Shared Neighborhood Hits	3
SwissProt Accessions	Q2EMV9, Q571C6, Q8BN35, Q8VDT6	Gene names	Parp14, Kiaa1268
Domain Architecture	No domain graphic available
Description	Poly [ADP-ribose] polymerase 14 (EC 2.4.2.30) (PARP-14) (Collaborator of STAT6) (CoaSt6).

UCP1_MOUSE
NC score	0.007546 (rank : 69)	θ value	8.99809 (rank : 24)
Query Neighborhood Hits	24	Target Neighborhood Hits	66	Shared Neighborhood Hits	2
SwissProt Accessions	P12242	Gene names	Ucp1, Ucp
Domain Architecture
Description	Mitochondrial brown fat uncoupling protein 1 (UCP 1) (Thermogenin).