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Network neighborhood for query Sequence : DBNL_HUMAN

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DBNL_HUMAN
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DBNL_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	244	Target Neighborhood Hits	244	Shared Neighborhood Hits	244
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	1.08164e-170 (rank : 2)	NC score	0.971926 (rank : 2)
Query Neighborhood Hits	244	Target Neighborhood Hits	306	Shared Neighborhood Hits	190
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DREB_HUMAN
θ value	2.86122e-38 (rank : 3)	NC score	0.497094 (rank : 30)
Query Neighborhood Hits	244	Target Neighborhood Hits	450	Shared Neighborhood Hits	56
SwissProt Accessions	Q16643	Gene names	DBN1
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

DREB_MOUSE
θ value	8.32485e-38 (rank : 4)	NC score	0.499840 (rank : 28)
Query Neighborhood Hits	244	Target Neighborhood Hits	446	Shared Neighborhood Hits	58
SwissProt Accessions	Q9QXS6, Q922X1, Q9QXS5	Gene names	Dbn1, Drba
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

SRC8_MOUSE
θ value	1.13037e-18 (rank : 5)	NC score	0.710187 (rank : 4)
Query Neighborhood Hits	244	Target Neighborhood Hits	292	Shared Neighborhood Hits	153
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRC8_HUMAN
θ value	2.13179e-17 (rank : 6)	NC score	0.713172 (rank : 3)
Query Neighborhood Hits	244	Target Neighborhood Hits	269	Shared Neighborhood Hits	153
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

HCLS1_HUMAN
θ value	1.058e-16 (rank : 7)	NC score	0.694494 (rank : 6)
Query Neighborhood Hits	244	Target Neighborhood Hits	358	Shared Neighborhood Hits	152
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	5.25075e-16 (rank : 8)	NC score	0.699813 (rank : 5)
Query Neighborhood Hits	244	Target Neighborhood Hits	329	Shared Neighborhood Hits	153
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

LASP1_HUMAN
θ value	4.76016e-09 (rank : 9)	NC score	0.521081 (rank : 15)
Query Neighborhood Hits	244	Target Neighborhood Hits	293	Shared Neighborhood Hits	135
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	2.36244e-08 (rank : 10)	NC score	0.515481 (rank : 20)
Query Neighborhood Hits	244	Target Neighborhood Hits	297	Shared Neighborhood Hits	135
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

NEBU_HUMAN
θ value	8.97725e-08 (rank : 11)	NC score	0.428174 (rank : 53)
Query Neighborhood Hits	244	Target Neighborhood Hits	420	Shared Neighborhood Hits	149
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

STAM1_MOUSE
θ value	4.45536e-07 (rank : 12)	NC score	0.517679 (rank : 17)
Query Neighborhood Hits	244	Target Neighborhood Hits	273	Shared Neighborhood Hits	151
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

PACN2_MOUSE
θ value	5.81887e-07 (rank : 13)	NC score	0.543247 (rank : 9)
Query Neighborhood Hits	244	Target Neighborhood Hits	382	Shared Neighborhood Hits	158
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

SH3G2_HUMAN
θ value	7.59969e-07 (rank : 14)	NC score	0.547668 (rank : 7)
Query Neighborhood Hits	244	Target Neighborhood Hits	324	Shared Neighborhood Hits	165
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

NEBL_HUMAN
θ value	9.92553e-07 (rank : 15)	NC score	0.469741 (rank : 37)
Query Neighborhood Hits	244	Target Neighborhood Hits	457	Shared Neighborhood Hits	156
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

PACN2_HUMAN
θ value	9.92553e-07 (rank : 16)	NC score	0.541811 (rank : 10)
Query Neighborhood Hits	244	Target Neighborhood Hits	339	Shared Neighborhood Hits	158
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

STAM1_HUMAN
θ value	1.69304e-06 (rank : 17)	NC score	0.519096 (rank : 16)
Query Neighborhood Hits	244	Target Neighborhood Hits	271	Shared Neighborhood Hits	152
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

PACN1_HUMAN
θ value	3.77169e-06 (rank : 18)	NC score	0.528264 (rank : 14)
Query Neighborhood Hits	244	Target Neighborhood Hits	320	Shared Neighborhood Hits	154
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	3.77169e-06 (rank : 19)	NC score	0.531109 (rank : 13)
Query Neighborhood Hits	244	Target Neighborhood Hits	283	Shared Neighborhood Hits	153
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

ITSN1_MOUSE
θ value	8.40245e-06 (rank : 20)	NC score	0.351339 (rank : 79)
Query Neighborhood Hits	244	Target Neighborhood Hits	1669	Shared Neighborhood Hits	219
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

STAM2_MOUSE
θ value	1.09739e-05 (rank : 21)	NC score	0.499271 (rank : 29)
Query Neighborhood Hits	244	Target Neighborhood Hits	285	Shared Neighborhood Hits	150
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

SH3G2_MOUSE
θ value	1.43324e-05 (rank : 22)	NC score	0.534639 (rank : 12)
Query Neighborhood Hits	244	Target Neighborhood Hits	319	Shared Neighborhood Hits	162
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_MOUSE
θ value	1.87187e-05 (rank : 23)	NC score	0.547603 (rank : 8)
Query Neighborhood Hits	244	Target Neighborhood Hits	236	Shared Neighborhood Hits	157
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

PACN3_HUMAN
θ value	2.44474e-05 (rank : 24)	NC score	0.509016 (rank : 24)
Query Neighborhood Hits	244	Target Neighborhood Hits	385	Shared Neighborhood Hits	159
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	2.44474e-05 (rank : 25)	NC score	0.508885 (rank : 25)
Query Neighborhood Hits	244	Target Neighborhood Hits	380	Shared Neighborhood Hits	154
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

SH3G3_HUMAN
θ value	2.44474e-05 (rank : 26)	NC score	0.536948 (rank : 11)
Query Neighborhood Hits	244	Target Neighborhood Hits	222	Shared Neighborhood Hits	151
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

ITSN1_HUMAN
θ value	3.19293e-05 (rank : 27)	NC score	0.351665 (rank : 78)
Query Neighborhood Hits	244	Target Neighborhood Hits	1757	Shared Neighborhood Hits	224
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

STAM2_HUMAN
θ value	4.1701e-05 (rank : 28)	NC score	0.488370 (rank : 35)
Query Neighborhood Hits	244	Target Neighborhood Hits	288	Shared Neighborhood Hits	154
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

COTL1_HUMAN
θ value	5.44631e-05 (rank : 29)	NC score	0.248016 (rank : 110)
Query Neighborhood Hits	244	Target Neighborhood Hits	6	Shared Neighborhood Hits	6
SwissProt Accessions	Q14019, Q86XM5	Gene names	COTL1, CLP
Domain Architecture
Description	Coactosin-like protein.

PLCG1_MOUSE
θ value	5.44631e-05 (rank : 30)	NC score	0.366081 (rank : 73)
Query Neighborhood Hits	244	Target Neighborhood Hits	314	Shared Neighborhood Hits	137
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

SH3G1_HUMAN
θ value	5.44631e-05 (rank : 31)	NC score	0.517193 (rank : 18)
Query Neighborhood Hits	244	Target Neighborhood Hits	307	Shared Neighborhood Hits	156
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

ARHG4_HUMAN
θ value	7.1131e-05 (rank : 32)	NC score	0.324638 (rank : 89)
Query Neighborhood Hits	244	Target Neighborhood Hits	242	Shared Neighborhood Hits	136
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

COTL1_MOUSE
θ value	9.29e-05 (rank : 33)	NC score	0.242211 (rank : 113)
Query Neighborhood Hits	244	Target Neighborhood Hits	6	Shared Neighborhood Hits	6
SwissProt Accessions	Q9CQI6	Gene names	Cotl1, Clp
Domain Architecture
Description	Coactosin-like protein.

M3K10_HUMAN
θ value	0.000158464 (rank : 34)	NC score	0.122420 (rank : 180)
Query Neighborhood Hits	244	Target Neighborhood Hits	1071	Shared Neighborhood Hits	143
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

GRAP2_HUMAN
θ value	0.00020696 (rank : 35)	NC score	0.458680 (rank : 42)
Query Neighborhood Hits	244	Target Neighborhood Hits	304	Shared Neighborhood Hits	154
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

ITSN2_HUMAN
θ value	0.000270298 (rank : 36)	NC score	0.356618 (rank : 77)
Query Neighborhood Hits	244	Target Neighborhood Hits	1173	Shared Neighborhood Hits	213
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN2_MOUSE
θ value	0.000270298 (rank : 37)	NC score	0.341948 (rank : 83)
Query Neighborhood Hits	244	Target Neighborhood Hits	1371	Shared Neighborhood Hits	211
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

PLCG1_HUMAN
θ value	0.000270298 (rank : 38)	NC score	0.349925 (rank : 81)
Query Neighborhood Hits	244	Target Neighborhood Hits	293	Shared Neighborhood Hits	133
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

CRKL_MOUSE
θ value	0.000461057 (rank : 39)	NC score	0.426369 (rank : 55)
Query Neighborhood Hits	244	Target Neighborhood Hits	307	Shared Neighborhood Hits	149
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

MYO1F_HUMAN
θ value	0.000461057 (rank : 40)	NC score	0.238392 (rank : 114)
Query Neighborhood Hits	244	Target Neighborhood Hits	275	Shared Neighborhood Hits	153
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

SH3G1_MOUSE
θ value	0.000461057 (rank : 41)	NC score	0.511864 (rank : 22)
Query Neighborhood Hits	244	Target Neighborhood Hits	291	Shared Neighborhood Hits	153
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3K1_HUMAN
θ value	0.000461057 (rank : 42)	NC score	0.516513 (rank : 19)
Query Neighborhood Hits	244	Target Neighborhood Hits	341	Shared Neighborhood Hits	146
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

GRAP_HUMAN
θ value	0.000602161 (rank : 43)	NC score	0.429338 (rank : 51)
Query Neighborhood Hits	244	Target Neighborhood Hits	307	Shared Neighborhood Hits	151
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

M3KL4_HUMAN
θ value	0.000602161 (rank : 44)	NC score	0.146116 (rank : 154)
Query Neighborhood Hits	244	Target Neighborhood Hits	1087	Shared Neighborhood Hits	156
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

MYO1F_MOUSE
θ value	0.000602161 (rank : 45)	NC score	0.236955 (rank : 115)
Query Neighborhood Hits	244	Target Neighborhood Hits	262	Shared Neighborhood Hits	152
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

SH3K1_MOUSE
θ value	0.000602161 (rank : 46)	NC score	0.514019 (rank : 21)
Query Neighborhood Hits	244	Target Neighborhood Hits	332	Shared Neighborhood Hits	148
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

ABI2_HUMAN
θ value	0.000786445 (rank : 47)	NC score	0.500888 (rank : 27)
Query Neighborhood Hits	244	Target Neighborhood Hits	350	Shared Neighborhood Hits	141
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	0.000786445 (rank : 48)	NC score	0.506033 (rank : 26)
Query Neighborhood Hits	244	Target Neighborhood Hits	266	Shared Neighborhood Hits	140
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

CRKL_HUMAN
θ value	0.000786445 (rank : 49)	NC score	0.426468 (rank : 54)
Query Neighborhood Hits	244	Target Neighborhood Hits	313	Shared Neighborhood Hits	150
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

GRAP2_MOUSE
θ value	0.000786445 (rank : 50)	NC score	0.461913 (rank : 40)
Query Neighborhood Hits	244	Target Neighborhood Hits	297	Shared Neighborhood Hits	153
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

ARHG7_HUMAN
θ value	0.00102713 (rank : 51)	NC score	0.422349 (rank : 58)
Query Neighborhood Hits	244	Target Neighborhood Hits	347	Shared Neighborhood Hits	148
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
θ value	0.00102713 (rank : 52)	NC score	0.426369 (rank : 56)
Query Neighborhood Hits	244	Target Neighborhood Hits	396	Shared Neighborhood Hits	153
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

MYO1E_HUMAN
θ value	0.00102713 (rank : 53)	NC score	0.229407 (rank : 117)
Query Neighborhood Hits	244	Target Neighborhood Hits	293	Shared Neighborhood Hits	153
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

SNX18_HUMAN
θ value	0.00102713 (rank : 54)	NC score	0.371739 (rank : 72)
Query Neighborhood Hits	244	Target Neighborhood Hits	207	Shared Neighborhood Hits	125
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

SNX18_MOUSE
θ value	0.00102713 (rank : 55)	NC score	0.374669 (rank : 70)
Query Neighborhood Hits	244	Target Neighborhood Hits	198	Shared Neighborhood Hits	123
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

CD2AP_MOUSE
θ value	0.00175202 (rank : 56)	NC score	0.511068 (rank : 23)
Query Neighborhood Hits	244	Target Neighborhood Hits	336	Shared Neighborhood Hits	155
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

STAC_MOUSE
θ value	0.00298849 (rank : 57)	NC score	0.447021 (rank : 45)
Query Neighborhood Hits	244	Target Neighborhood Hits	268	Shared Neighborhood Hits	139
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_HUMAN
θ value	0.00390308 (rank : 58)	NC score	0.456534 (rank : 43)
Query Neighborhood Hits	244	Target Neighborhood Hits	276	Shared Neighborhood Hits	142
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ABI1_MOUSE
θ value	0.00509761 (rank : 59)	NC score	0.496394 (rank : 31)
Query Neighborhood Hits	244	Target Neighborhood Hits	246	Shared Neighborhood Hits	139
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

GRAP_MOUSE
θ value	0.00509761 (rank : 60)	NC score	0.426121 (rank : 57)
Query Neighborhood Hits	244	Target Neighborhood Hits	309	Shared Neighborhood Hits	155
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GRB2_HUMAN
θ value	0.00509761 (rank : 61)	NC score	0.446248 (rank : 46)
Query Neighborhood Hits	244	Target Neighborhood Hits	310	Shared Neighborhood Hits	154
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	0.00509761 (rank : 62)	NC score	0.446038 (rank : 47)
Query Neighborhood Hits	244	Target Neighborhood Hits	312	Shared Neighborhood Hits	154
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

VAV_HUMAN
θ value	0.00509761 (rank : 63)	NC score	0.361855 (rank : 76)
Query Neighborhood Hits	244	Target Neighborhood Hits	452	Shared Neighborhood Hits	155
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ABI1_HUMAN
θ value	0.00665767 (rank : 64)	NC score	0.480601 (rank : 36)
Query Neighborhood Hits	244	Target Neighborhood Hits	257	Shared Neighborhood Hits	138
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

PLCG2_HUMAN
θ value	0.00665767 (rank : 65)	NC score	0.341697 (rank : 84)
Query Neighborhood Hits	244	Target Neighborhood Hits	280	Shared Neighborhood Hits	137
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

VAV_MOUSE
θ value	0.00869519 (rank : 66)	NC score	0.362111 (rank : 75)
Query Neighborhood Hits	244	Target Neighborhood Hits	430	Shared Neighborhood Hits	152
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VINEX_MOUSE
θ value	0.00869519 (rank : 67)	NC score	0.488477 (rank : 34)
Query Neighborhood Hits	244	Target Neighborhood Hits	286	Shared Neighborhood Hits	156
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

ABI3_MOUSE
θ value	0.0113563 (rank : 68)	NC score	0.447373 (rank : 44)
Query Neighborhood Hits	244	Target Neighborhood Hits	227	Shared Neighborhood Hits	120
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

NCK1_HUMAN
θ value	0.0113563 (rank : 69)	NC score	0.412285 (rank : 62)
Query Neighborhood Hits	244	Target Neighborhood Hits	312	Shared Neighborhood Hits	149
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

OSTF1_HUMAN
θ value	0.0113563 (rank : 70)	NC score	0.371869 (rank : 71)
Query Neighborhood Hits	244	Target Neighborhood Hits	466	Shared Neighborhood Hits	148
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

CRK_HUMAN
θ value	0.0148317 (rank : 71)	NC score	0.398567 (rank : 64)
Query Neighborhood Hits	244	Target Neighborhood Hits	308	Shared Neighborhood Hits	147
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

DNMBP_MOUSE
θ value	0.0148317 (rank : 72)	NC score	0.394052 (rank : 68)
Query Neighborhood Hits	244	Target Neighborhood Hits	435	Shared Neighborhood Hits	159
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

NCK2_HUMAN
θ value	0.0148317 (rank : 73)	NC score	0.412412 (rank : 61)
Query Neighborhood Hits	244	Target Neighborhood Hits	310	Shared Neighborhood Hits	151
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

RUSC1_HUMAN
θ value	0.0148317 (rank : 74)	NC score	0.300071 (rank : 96)
Query Neighborhood Hits	244	Target Neighborhood Hits	226	Shared Neighborhood Hits	112
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

RUSC1_MOUSE
θ value	0.0148317 (rank : 75)	NC score	0.294138 (rank : 98)
Query Neighborhood Hits	244	Target Neighborhood Hits	206	Shared Neighborhood Hits	108
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

CRK_MOUSE
θ value	0.0193708 (rank : 76)	NC score	0.400975 (rank : 63)
Query Neighborhood Hits	244	Target Neighborhood Hits	314	Shared Neighborhood Hits	147
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SPTA1_HUMAN
θ value	0.0193708 (rank : 77)	NC score	0.199859 (rank : 128)
Query Neighborhood Hits	244	Target Neighborhood Hits	748	Shared Neighborhood Hits	172
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA1_MOUSE
θ value	0.0193708 (rank : 78)	NC score	0.209988 (rank : 125)
Query Neighborhood Hits	244	Target Neighborhood Hits	675	Shared Neighborhood Hits	165
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

VINEX_HUMAN
θ value	0.0193708 (rank : 79)	NC score	0.490830 (rank : 33)
Query Neighborhood Hits	244	Target Neighborhood Hits	270	Shared Neighborhood Hits	157
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

ABI3_HUMAN
θ value	0.0252991 (rank : 80)	NC score	0.442073 (rank : 48)
Query Neighborhood Hits	244	Target Neighborhood Hits	227	Shared Neighborhood Hits	120
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AHI1_MOUSE
θ value	0.0252991 (rank : 81)	NC score	0.327820 (rank : 88)
Query Neighborhood Hits	244	Target Neighborhood Hits	496	Shared Neighborhood Hits	151
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

OSTF1_MOUSE
θ value	0.0252991 (rank : 82)	NC score	0.364314 (rank : 74)
Query Neighborhood Hits	244	Target Neighborhood Hits	467	Shared Neighborhood Hits	149
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

DNMBP_HUMAN
θ value	0.0330416 (rank : 83)	NC score	0.396792 (rank : 67)
Query Neighborhood Hits	244	Target Neighborhood Hits	413	Shared Neighborhood Hits	160
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

SRBS1_MOUSE
θ value	0.0330416 (rank : 84)	NC score	0.466137 (rank : 38)
Query Neighborhood Hits	244	Target Neighborhood Hits	409	Shared Neighborhood Hits	158
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

STAC3_HUMAN
θ value	0.0330416 (rank : 85)	NC score	0.415612 (rank : 60)
Query Neighborhood Hits	244	Target Neighborhood Hits	228	Shared Neighborhood Hits	132
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	0.0330416 (rank : 86)	NC score	0.416260 (rank : 59)
Query Neighborhood Hits	244	Target Neighborhood Hits	232	Shared Neighborhood Hits	134
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

ARHG6_MOUSE
θ value	0.0431538 (rank : 87)	NC score	0.398544 (rank : 65)
Query Neighborhood Hits	244	Target Neighborhood Hits	394	Shared Neighborhood Hits	156
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

CD2AP_HUMAN
θ value	0.0431538 (rank : 88)	NC score	0.494576 (rank : 32)
Query Neighborhood Hits	244	Target Neighborhood Hits	315	Shared Neighborhood Hits	154
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SYCP1_MOUSE
θ value	0.0431538 (rank : 89)	NC score	0.061960 (rank : 310)
Query Neighborhood Hits	244	Target Neighborhood Hits	1456	Shared Neighborhood Hits	75
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

SHLB1_HUMAN
θ value	0.0563607 (rank : 90)	NC score	0.302139 (rank : 95)
Query Neighborhood Hits	244	Target Neighborhood Hits	96	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHLB1_MOUSE
θ value	0.0563607 (rank : 91)	NC score	0.307071 (rank : 93)
Query Neighborhood Hits	244	Target Neighborhood Hits	101	Shared Neighborhood Hits	82
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

TEC_HUMAN
θ value	0.0563607 (rank : 92)	NC score	0.096092 (rank : 212)
Query Neighborhood Hits	244	Target Neighborhood Hits	1006	Shared Neighborhood Hits	121
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

AHI1_HUMAN
θ value	0.0736092 (rank : 93)	NC score	0.323776 (rank : 90)
Query Neighborhood Hits	244	Target Neighborhood Hits	537	Shared Neighborhood Hits	151
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

SRBS1_HUMAN
θ value	0.0736092 (rank : 94)	NC score	0.464482 (rank : 39)
Query Neighborhood Hits	244	Target Neighborhood Hits	396	Shared Neighborhood Hits	161
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

ARHG6_HUMAN
θ value	0.0961366 (rank : 95)	NC score	0.391915 (rank : 69)
Query Neighborhood Hits	244	Target Neighborhood Hits	376	Shared Neighborhood Hits	155
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

VAV2_HUMAN
θ value	0.0961366 (rank : 96)	NC score	0.329326 (rank : 87)
Query Neighborhood Hits	244	Target Neighborhood Hits	453	Shared Neighborhood Hits	149
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
θ value	0.0961366 (rank : 97)	NC score	0.329970 (rank : 86)
Query Neighborhood Hits	244	Target Neighborhood Hits	456	Shared Neighborhood Hits	149
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

DDEF1_MOUSE
θ value	0.125558 (rank : 98)	NC score	0.230174 (rank : 116)
Query Neighborhood Hits	244	Target Neighborhood Hits	592	Shared Neighborhood Hits	128
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

RHG26_HUMAN
θ value	0.125558 (rank : 99)	NC score	0.226834 (rank : 118)
Query Neighborhood Hits	244	Target Neighborhood Hits	281	Shared Neighborhood Hits	124
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

SRC_HUMAN
θ value	0.125558 (rank : 100)	NC score	0.127313 (rank : 171)
Query Neighborhood Hits	244	Target Neighborhood Hits	1058	Shared Neighborhood Hits	149
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

FGR_MOUSE
θ value	0.163984 (rank : 101)	NC score	0.126413 (rank : 174)
Query Neighborhood Hits	244	Target Neighborhood Hits	1069	Shared Neighborhood Hits	147
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

ITK_HUMAN
θ value	0.163984 (rank : 102)	NC score	0.085141 (rank : 233)
Query Neighborhood Hits	244	Target Neighborhood Hits	1016	Shared Neighborhood Hits	115
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

ITK_MOUSE
θ value	0.163984 (rank : 103)	NC score	0.081298 (rank : 243)
Query Neighborhood Hits	244	Target Neighborhood Hits	985	Shared Neighborhood Hits	103
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

M3K11_HUMAN
θ value	0.163984 (rank : 104)	NC score	0.124299 (rank : 177)
Query Neighborhood Hits	244	Target Neighborhood Hits	1136	Shared Neighborhood Hits	141
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

PPIP1_MOUSE
θ value	0.163984 (rank : 105)	NC score	0.439561 (rank : 49)
Query Neighborhood Hits	244	Target Neighborhood Hits	377	Shared Neighborhood Hits	167
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

SHLB2_HUMAN
θ value	0.163984 (rank : 106)	NC score	0.277112 (rank : 104)
Query Neighborhood Hits	244	Target Neighborhood Hits	86	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	0.163984 (rank : 107)	NC score	0.279144 (rank : 101)
Query Neighborhood Hits	244	Target Neighborhood Hits	88	Shared Neighborhood Hits	68
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

DDEF2_HUMAN
θ value	0.21417 (rank : 108)	NC score	0.201977 (rank : 127)
Query Neighborhood Hits	244	Target Neighborhood Hits	599	Shared Neighborhood Hits	129
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

LRC27_HUMAN
θ value	0.21417 (rank : 109)	NC score	0.051077 (rank : 401)
Query Neighborhood Hits	244	Target Neighborhood Hits	710	Shared Neighborhood Hits	39
SwissProt Accessions	Q9C0I9, Q5SZH6, Q5SZH8, Q5SZH9, Q86XT5, Q8N7C8, Q8NA21	Gene names	LRRC27, KIAA1674
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 27.

UBP8_HUMAN
θ value	0.21417 (rank : 110)	NC score	0.032164 (rank : 439)
Query Neighborhood Hits	244	Target Neighborhood Hits	751	Shared Neighborhood Hits	55
SwissProt Accessions	P40818, Q7Z3U2, Q86VA0, Q8IWI7	Gene names	USP8, KIAA0055, UBPY
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (hUBPy).

PPIP1_HUMAN
θ value	0.279714 (rank : 111)	NC score	0.435220 (rank : 50)
Query Neighborhood Hits	244	Target Neighborhood Hits	389	Shared Neighborhood Hits	169
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

DOCK1_HUMAN
θ value	0.365318 (rank : 112)	NC score	0.147175 (rank : 153)
Query Neighborhood Hits	244	Target Neighborhood Hits	191	Shared Neighborhood Hits	99
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

SPTA2_HUMAN
θ value	0.365318 (rank : 113)	NC score	0.199468 (rank : 130)
Query Neighborhood Hits	244	Target Neighborhood Hits	888	Shared Neighborhood Hits	174
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

TAOK1_HUMAN
θ value	0.365318 (rank : 114)	NC score	0.043060 (rank : 420)
Query Neighborhood Hits	244	Target Neighborhood Hits	1734	Shared Neighborhood Hits	91
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

TAOK1_MOUSE
θ value	0.365318 (rank : 115)	NC score	0.043121 (rank : 419)
Query Neighborhood Hits	244	Target Neighborhood Hits	1720	Shared Neighborhood Hits	90
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

ARHG4_MOUSE
θ value	0.47712 (rank : 116)	NC score	0.243420 (rank : 112)
Query Neighborhood Hits	244	Target Neighborhood Hits	185	Shared Neighborhood Hits	99
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ASPP1_HUMAN
θ value	0.47712 (rank : 117)	NC score	0.211906 (rank : 123)
Query Neighborhood Hits	244	Target Neighborhood Hits	956	Shared Neighborhood Hits	156
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

M3K9_HUMAN
θ value	0.47712 (rank : 118)	NC score	0.120477 (rank : 181)
Query Neighborhood Hits	244	Target Neighborhood Hits	1123	Shared Neighborhood Hits	149
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

MED12_HUMAN
θ value	0.47712 (rank : 119)	NC score	0.054768 (rank : 364)
Query Neighborhood Hits	244	Target Neighborhood Hits	262	Shared Neighborhood Hits	26
SwissProt Accessions	Q93074, O15410, O75557, Q9UHV6, Q9UND7	Gene names	MED12, ARC240, CAGH45, HOPA, KIAA0192, TNRC11, TRAP230
Domain Architecture	No domain graphic available
Description	Mediator of RNA polymerase II transcription subunit 12 (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (OPA-containing protein) (Trinucleotide repeat-containing gene 11 protein).

SMC2_HUMAN
θ value	0.47712 (rank : 120)	NC score	0.060038 (rank : 321)
Query Neighborhood Hits	244	Target Neighborhood Hits	1405	Shared Neighborhood Hits	81
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

TEC_MOUSE
θ value	0.47712 (rank : 121)	NC score	0.091075 (rank : 223)
Query Neighborhood Hits	244	Target Neighborhood Hits	1006	Shared Neighborhood Hits	121
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

VAV3_HUMAN
θ value	0.47712 (rank : 122)	NC score	0.309225 (rank : 92)
Query Neighborhood Hits	244	Target Neighborhood Hits	398	Shared Neighborhood Hits	149
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VAV3_MOUSE
θ value	0.47712 (rank : 123)	NC score	0.306411 (rank : 94)
Query Neighborhood Hits	244	Target Neighborhood Hits	404	Shared Neighborhood Hits	148
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

YES_MOUSE
θ value	0.47712 (rank : 124)	NC score	0.125333 (rank : 175)
Query Neighborhood Hits	244	Target Neighborhood Hits	1052	Shared Neighborhood Hits	145
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ES8L3_HUMAN
θ value	0.62314 (rank : 125)	NC score	0.184662 (rank : 137)
Query Neighborhood Hits	244	Target Neighborhood Hits	206	Shared Neighborhood Hits	110
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FGR_HUMAN
θ value	0.62314 (rank : 126)	NC score	0.129171 (rank : 169)
Query Neighborhood Hits	244	Target Neighborhood Hits	1067	Shared Neighborhood Hits	147
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FRK_HUMAN
θ value	0.62314 (rank : 127)	NC score	0.102976 (rank : 199)
Query Neighborhood Hits	244	Target Neighborhood Hits	1058	Shared Neighborhood Hits	145
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

IASPP_HUMAN
θ value	0.62314 (rank : 128)	NC score	0.216332 (rank : 120)
Query Neighborhood Hits	244	Target Neighborhood Hits	688	Shared Neighborhood Hits	133
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

RGNEF_MOUSE
θ value	0.62314 (rank : 129)	NC score	0.093068 (rank : 221)
Query Neighborhood Hits	244	Target Neighborhood Hits	641	Shared Neighborhood Hits	59
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

SRC_MOUSE
θ value	0.62314 (rank : 130)	NC score	0.110180 (rank : 192)
Query Neighborhood Hits	244	Target Neighborhood Hits	1033	Shared Neighborhood Hits	135
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

YES_HUMAN
θ value	0.62314 (rank : 131)	NC score	0.123727 (rank : 178)
Query Neighborhood Hits	244	Target Neighborhood Hits	1059	Shared Neighborhood Hits	145
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

ARHG9_HUMAN
θ value	0.813845 (rank : 132)	NC score	0.277338 (rank : 103)
Query Neighborhood Hits	244	Target Neighborhood Hits	235	Shared Neighborhood Hits	125
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	0.813845 (rank : 133)	NC score	0.278293 (rank : 102)
Query Neighborhood Hits	244	Target Neighborhood Hits	234	Shared Neighborhood Hits	127
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ASPP1_MOUSE
θ value	0.813845 (rank : 134)	NC score	0.214458 (rank : 122)
Query Neighborhood Hits	244	Target Neighborhood Hits	1244	Shared Neighborhood Hits	165
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

FYN_HUMAN
θ value	0.813845 (rank : 135)	NC score	0.128671 (rank : 170)
Query Neighborhood Hits	244	Target Neighborhood Hits	1078	Shared Neighborhood Hits	149
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	0.813845 (rank : 136)	NC score	0.131062 (rank : 167)
Query Neighborhood Hits	244	Target Neighborhood Hits	1073	Shared Neighborhood Hits	149
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

GOGA1_HUMAN
θ value	0.813845 (rank : 137)	NC score	0.050542 (rank : 407)
Query Neighborhood Hits	244	Target Neighborhood Hits	1222	Shared Neighborhood Hits	70
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

IASPP_MOUSE
θ value	0.813845 (rank : 138)	NC score	0.197802 (rank : 132)
Query Neighborhood Hits	244	Target Neighborhood Hits	1024	Shared Neighborhood Hits	138
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IFT81_MOUSE
θ value	0.813845 (rank : 139)	NC score	0.057474 (rank : 345)
Query Neighborhood Hits	244	Target Neighborhood Hits	959	Shared Neighborhood Hits	60
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

KLC4_MOUSE
θ value	0.813845 (rank : 140)	NC score	0.026747 (rank : 444)
Query Neighborhood Hits	244	Target Neighborhood Hits	336	Shared Neighborhood Hits	23
SwissProt Accessions	Q9DBS5, Q3TCC5	Gene names	Klc4, Knsl8
Domain Architecture
Description	Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8).

NCF4_MOUSE
θ value	0.813845 (rank : 141)	NC score	0.428327 (rank : 52)
Query Neighborhood Hits	244	Target Neighborhood Hits	177	Shared Neighborhood Hits	128
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NPHP1_MOUSE
θ value	0.813845 (rank : 142)	NC score	0.350000 (rank : 80)
Query Neighborhood Hits	244	Target Neighborhood Hits	267	Shared Neighborhood Hits	147
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

ZC313_HUMAN
θ value	0.813845 (rank : 143)	NC score	0.076139 (rank : 263)
Query Neighborhood Hits	244	Target Neighborhood Hits	772	Shared Neighborhood Hits	55
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

GOGA4_HUMAN
θ value	1.06291 (rank : 144)	NC score	0.060416 (rank : 319)
Query Neighborhood Hits	244	Target Neighborhood Hits	2034	Shared Neighborhood Hits	103
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

MYH10_HUMAN
θ value	1.06291 (rank : 145)	NC score	0.059345 (rank : 328)
Query Neighborhood Hits	244	Target Neighborhood Hits	1620	Shared Neighborhood Hits	90
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH10_MOUSE
θ value	1.06291 (rank : 146)	NC score	0.059993 (rank : 324)
Query Neighborhood Hits	244	Target Neighborhood Hits	1612	Shared Neighborhood Hits	90
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

NFH_MOUSE
θ value	1.06291 (rank : 147)	NC score	0.021144 (rank : 451)
Query Neighborhood Hits	244	Target Neighborhood Hits	2247	Shared Neighborhood Hits	74
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

P85A_HUMAN
θ value	1.06291 (rank : 148)	NC score	0.150699 (rank : 150)
Query Neighborhood Hits	244	Target Neighborhood Hits	479	Shared Neighborhood Hits	106
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	1.06291 (rank : 149)	NC score	0.155792 (rank : 145)
Query Neighborhood Hits	244	Target Neighborhood Hits	435	Shared Neighborhood Hits	105
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

TXD11_HUMAN
θ value	1.06291 (rank : 150)	NC score	0.033725 (rank : 437)
Query Neighborhood Hits	244	Target Neighborhood Hits	402	Shared Neighborhood Hits	27
SwissProt Accessions	Q6PKC3, O95887, Q6PJA6, Q8N2Q4, Q96K45, Q96K53	Gene names	TXNDC11, EFP1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 11 (EF-hand-binding protein 1).

BAG3_HUMAN
θ value	1.38821 (rank : 151)	NC score	0.024811 (rank : 447)
Query Neighborhood Hits	244	Target Neighborhood Hits	314	Shared Neighborhood Hits	15
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

BTK_HUMAN
θ value	1.38821 (rank : 152)	NC score	0.112775 (rank : 186)
Query Neighborhood Hits	244	Target Neighborhood Hits	1026	Shared Neighborhood Hits	147
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

CJ049_HUMAN
θ value	1.38821 (rank : 153)	NC score	0.056315 (rank : 350)
Query Neighborhood Hits	244	Target Neighborhood Hits	90	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WVF2	Gene names	C10orf49
Domain Architecture	No domain graphic available
Description	Protein C10orf49 precursor.

CLCB_HUMAN
θ value	1.38821 (rank : 154)	NC score	0.059172 (rank : 330)
Query Neighborhood Hits	244	Target Neighborhood Hits	137	Shared Neighborhood Hits	17
SwissProt Accessions	P09497, Q6FHW1	Gene names	CLTB
Domain Architecture
Description	Clathrin light chain B (Lcb).

CLCB_MOUSE
θ value	1.38821 (rank : 155)	NC score	0.058004 (rank : 342)
Query Neighborhood Hits	244	Target Neighborhood Hits	119	Shared Neighborhood Hits	16
SwissProt Accessions	Q6IRU5, Q8BR04, Q8CDX9, Q9CV35	Gene names	Cltb
Domain Architecture	No domain graphic available
Description	Clathrin light chain B (Lcb).

CT032_HUMAN
θ value	1.38821 (rank : 156)	NC score	0.322089 (rank : 91)
Query Neighborhood Hits	244	Target Neighborhood Hits	235	Shared Neighborhood Hits	119
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DESP_HUMAN
θ value	1.38821 (rank : 157)	NC score	0.050053 (rank : 415)
Query Neighborhood Hits	244	Target Neighborhood Hits	1470	Shared Neighborhood Hits	91
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

LAD1_MOUSE
θ value	1.38821 (rank : 158)	NC score	0.035038 (rank : 436)
Query Neighborhood Hits	244	Target Neighborhood Hits	391	Shared Neighborhood Hits	26
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

MYH9_HUMAN
θ value	1.38821 (rank : 159)	NC score	0.060944 (rank : 315)
Query Neighborhood Hits	244	Target Neighborhood Hits	1762	Shared Neighborhood Hits	97
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

MYH9_MOUSE
θ value	1.38821 (rank : 160)	NC score	0.059984 (rank : 325)
Query Neighborhood Hits	244	Target Neighborhood Hits	1829	Shared Neighborhood Hits	96
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

NTBP1_MOUSE
θ value	1.38821 (rank : 161)	NC score	0.073776 (rank : 270)
Query Neighborhood Hits	244	Target Neighborhood Hits	528	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BRM2, Q8CAA8	Gene names	Scyl1bp1, Ntklbp1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like-binding protein 1 (NTKL-binding protein 1) (NTKL-BP1) (mNTKL-BP1) (SCY1-like 1-binding protein 1) (SCYL1-binding protein 1) (SCYL1-BP1).

SNIP1_HUMAN
θ value	1.38821 (rank : 162)	NC score	0.038750 (rank : 428)
Query Neighborhood Hits	244	Target Neighborhood Hits	80	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TAD8, Q96SP9, Q9H9T7	Gene names	SNIP1
Domain Architecture
Description	Smad nuclear-interacting protein 1.

BTK_MOUSE
θ value	1.81305 (rank : 163)	NC score	0.107424 (rank : 196)
Query Neighborhood Hits	244	Target Neighborhood Hits	1017	Shared Neighborhood Hits	140
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

CASL_HUMAN
θ value	1.81305 (rank : 164)	NC score	0.256422 (rank : 108)
Query Neighborhood Hits	244	Target Neighborhood Hits	259	Shared Neighborhood Hits	127
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	1.81305 (rank : 165)	NC score	0.258339 (rank : 107)
Query Neighborhood Hits	244	Target Neighborhood Hits	225	Shared Neighborhood Hits	129
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CCD91_HUMAN
θ value	1.81305 (rank : 166)	NC score	0.081398 (rank : 242)
Query Neighborhood Hits	244	Target Neighborhood Hits	868	Shared Neighborhood Hits	61
SwissProt Accessions	Q7Z6B0, Q68D43, Q6IA78, Q8NEN7, Q9NUW9	Gene names	CCDC91, GGABP
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein).

CNTRB_MOUSE
θ value	1.81305 (rank : 167)	NC score	0.066202 (rank : 290)
Query Neighborhood Hits	244	Target Neighborhood Hits	1029	Shared Neighborhood Hits	75
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

DHX16_HUMAN
θ value	1.81305 (rank : 168)	NC score	0.026676 (rank : 445)
Query Neighborhood Hits	244	Target Neighborhood Hits	356	Shared Neighborhood Hits	41
SwissProt Accessions	O60231, O60322, Q969X7, Q96QC1	Gene names	DHX16, DBP2, DDX16, KIAA0577
Domain Architecture
Description	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.1.-) (DEAH-box protein 16) (ATP-dependent RNA helicase #3).

MDC1_HUMAN
θ value	1.81305 (rank : 169)	NC score	0.052617 (rank : 380)
Query Neighborhood Hits	244	Target Neighborhood Hits	1446	Shared Neighborhood Hits	54
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

NEST_HUMAN
θ value	1.81305 (rank : 170)	NC score	0.045512 (rank : 418)
Query Neighborhood Hits	244	Target Neighborhood Hits	1305	Shared Neighborhood Hits	57
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

PEX13_MOUSE
θ value	1.81305 (rank : 171)	NC score	0.293127 (rank : 99)
Query Neighborhood Hits	244	Target Neighborhood Hits	126	Shared Neighborhood Hits	104
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

SMC1A_MOUSE
θ value	1.81305 (rank : 172)	NC score	0.064574 (rank : 298)
Query Neighborhood Hits	244	Target Neighborhood Hits	1384	Shared Neighborhood Hits	86
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

ZN318_HUMAN
θ value	1.81305 (rank : 173)	NC score	0.033500 (rank : 438)
Query Neighborhood Hits	244	Target Neighborhood Hits	497	Shared Neighborhood Hits	30
SwissProt Accessions	Q5VUA4, O94796, Q4G0E4, Q8NEM6, Q9UNU8, Q9Y2W9	Gene names	ZNF318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Endocrine regulatory protein).

AZI1_HUMAN
θ value	2.36792 (rank : 174)	NC score	0.064754 (rank : 296)
Query Neighborhood Hits	244	Target Neighborhood Hits	1000	Shared Neighborhood Hits	73
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

CCD11_HUMAN
θ value	2.36792 (rank : 175)	NC score	0.056706 (rank : 349)
Query Neighborhood Hits	244	Target Neighborhood Hits	822	Shared Neighborhood Hits	61
SwissProt Accessions	Q96M91	Gene names	CCDC11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

EPS8_HUMAN
θ value	2.36792 (rank : 176)	NC score	0.151880 (rank : 149)
Query Neighborhood Hits	244	Target Neighborhood Hits	151	Shared Neighborhood Hits	92
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

KI13A_HUMAN
θ value	2.36792 (rank : 177)	NC score	0.015772 (rank : 456)
Query Neighborhood Hits	244	Target Neighborhood Hits	359	Shared Neighborhood Hits	25
SwissProt Accessions	Q9H1H9, Q9H1H8	Gene names	KIF13A, RBKIN
Domain Architecture
Description	Kinesin-like protein KIF13A (Kinesin-like protein RBKIN).

NCF2_HUMAN
θ value	2.36792 (rank : 178)	NC score	0.459624 (rank : 41)
Query Neighborhood Hits	244	Target Neighborhood Hits	229	Shared Neighborhood Hits	134
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NPHP1_HUMAN
θ value	2.36792 (rank : 179)	NC score	0.298444 (rank : 97)
Query Neighborhood Hits	244	Target Neighborhood Hits	288	Shared Neighborhood Hits	136
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

PLCB3_HUMAN
θ value	2.36792 (rank : 180)	NC score	0.067504 (rank : 287)
Query Neighborhood Hits	244	Target Neighborhood Hits	445	Shared Neighborhood Hits	45
SwissProt Accessions	Q01970	Gene names	PLCB3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

T23O_MOUSE
θ value	2.36792 (rank : 181)	NC score	0.039989 (rank : 426)
Query Neighborhood Hits	244	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	P48776	Gene names	Tdo2, Tdo
Domain Architecture
Description	Tryptophan 2,3-dioxygenase (EC 1.13.11.11) (TO) (Tryptophan pyrrolase) (Tryptophanase) (Tryptophan oxygenase) (Tryptamin 2,3-dioxygenase) (TRPO).

TXK_MOUSE
θ value	2.36792 (rank : 182)	NC score	0.093365 (rank : 220)
Query Neighborhood Hits	244	Target Neighborhood Hits	980	Shared Neighborhood Hits	115
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

WDR22_HUMAN
θ value	2.36792 (rank : 183)	NC score	0.016432 (rank : 455)
Query Neighborhood Hits	244	Target Neighborhood Hits	328	Shared Neighborhood Hits	8
SwissProt Accessions	Q96JK2, O60559, Q8N3V3, Q8N3V5	Gene names	WDR22, BCRG2, KIAA1824
Domain Architecture
Description	WD repeat protein 22 (Breakpoint cluster region protein 2) (BCRP2).

ANM2_HUMAN
θ value	3.0926 (rank : 184)	NC score	0.215757 (rank : 121)
Query Neighborhood Hits	244	Target Neighborhood Hits	175	Shared Neighborhood Hits	126
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

CDC37_HUMAN
θ value	3.0926 (rank : 185)	NC score	0.071706 (rank : 273)
Query Neighborhood Hits	244	Target Neighborhood Hits	506	Shared Neighborhood Hits	37
SwissProt Accessions	Q16543	Gene names	CDC37
Domain Architecture
Description	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37).

CI093_HUMAN
θ value	3.0926 (rank : 186)	NC score	0.051221 (rank : 398)
Query Neighborhood Hits	244	Target Neighborhood Hits	1088	Shared Neighborhood Hits	75
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

CTGE5_MOUSE
θ value	3.0926 (rank : 187)	NC score	0.038233 (rank : 432)
Query Neighborhood Hits	244	Target Neighborhood Hits	928	Shared Neighborhood Hits	52
SwissProt Accessions	Q8R311, Q8CIE3	Gene names	Ctage5, Mea6, Mgea6
Domain Architecture	No domain graphic available
Description	Cutaneous T-cell lymphoma-associated antigen 5 homolog (cTAGE-5 protein) (Meningioma-expressed antigen 6).

DDEF2_MOUSE
θ value	3.0926 (rank : 188)	NC score	0.196314 (rank : 133)
Query Neighborhood Hits	244	Target Neighborhood Hits	625	Shared Neighborhood Hits	124
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

HM20A_HUMAN
θ value	3.0926 (rank : 189)	NC score	0.040055 (rank : 425)
Query Neighborhood Hits	244	Target Neighborhood Hits	343	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NP66, Q53G31, Q9NSF6	Gene names	HMG20A, HMGX1
Domain Architecture	No domain graphic available
Description	High mobility group protein 20A (HMG box-containing protein 20A) (HMG domain-containing protein HMGX1).

HM20A_MOUSE
θ value	3.0926 (rank : 190)	NC score	0.038641 (rank : 429)
Query Neighborhood Hits	244	Target Neighborhood Hits	348	Shared Neighborhood Hits	25
SwissProt Accessions	Q9DC33, Q3LSF9, Q6NV87, Q8BSK1, Q8C3C1, Q8CAA0, Q9CYG2	Gene names	Hmg20a, Ibraf
Domain Architecture	No domain graphic available
Description	High mobility group protein 20A (HMG box-containing protein 20A) (iBRAF) (Inhibitor of BRAF35) (HMG domain protein HMGX1).

IFT81_HUMAN
θ value	3.0926 (rank : 191)	NC score	0.046359 (rank : 417)
Query Neighborhood Hits	244	Target Neighborhood Hits	893	Shared Neighborhood Hits	51
SwissProt Accessions	Q8WYA0, Q8NB51, Q9BSV2, Q9UNY8	Gene names	IFT81, CDV1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

NCOR2_HUMAN
θ value	3.0926 (rank : 192)	NC score	0.035279 (rank : 435)
Query Neighborhood Hits	244	Target Neighborhood Hits	870	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

NCOR2_MOUSE
θ value	3.0926 (rank : 193)	NC score	0.036134 (rank : 434)
Query Neighborhood Hits	244	Target Neighborhood Hits	790	Shared Neighborhood Hits	51
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

NR1D2_HUMAN
θ value	3.0926 (rank : 194)	NC score	0.003930 (rank : 461)
Query Neighborhood Hits	244	Target Neighborhood Hits	115	Shared Neighborhood Hits	3
SwissProt Accessions	Q14995, O00402, Q86XD4	Gene names	NR1D2
Domain Architecture
Description	Orphan nuclear receptor NR1D2 (Rev-erb-beta) (EAR-1R) (Orphan nuclear hormone receptor BD73).

PLCB3_MOUSE
θ value	3.0926 (rank : 195)	NC score	0.063186 (rank : 305)
Query Neighborhood Hits	244	Target Neighborhood Hits	344	Shared Neighborhood Hits	35
SwissProt Accessions	P51432	Gene names	Plcb3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

SHAN2_MOUSE
θ value	3.0926 (rank : 196)	NC score	0.150299 (rank : 151)
Query Neighborhood Hits	244	Target Neighborhood Hits	446	Shared Neighborhood Hits	91
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

CCD41_MOUSE
θ value	4.03905 (rank : 197)	NC score	0.051900 (rank : 389)
Query Neighborhood Hits	244	Target Neighborhood Hits	1399	Shared Neighborhood Hits	81
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

CIP4_HUMAN
θ value	4.03905 (rank : 198)	NC score	0.138518 (rank : 160)
Query Neighborhood Hits	244	Target Neighborhood Hits	374	Shared Neighborhood Hits	82
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CS029_HUMAN
θ value	4.03905 (rank : 199)	NC score	0.039550 (rank : 427)
Query Neighborhood Hits	244	Target Neighborhood Hits	329	Shared Neighborhood Hits	33
SwissProt Accessions	Q8WUQ7, O75229, Q7LE08, Q9BTA6, Q9Y5A4	Gene names	C19orf29
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf29 (NY-REN-24 antigen).

GOGA4_MOUSE
θ value	4.03905 (rank : 200)	NC score	0.056302 (rank : 351)
Query Neighborhood Hits	244	Target Neighborhood Hits	1939	Shared Neighborhood Hits	100
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

MYO9B_HUMAN
θ value	4.03905 (rank : 201)	NC score	0.040192 (rank : 423)
Query Neighborhood Hits	244	Target Neighborhood Hits	641	Shared Neighborhood Hits	36
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

NCF1_MOUSE
θ value	4.03905 (rank : 202)	NC score	0.344898 (rank : 82)
Query Neighborhood Hits	244	Target Neighborhood Hits	198	Shared Neighborhood Hits	133
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

PEX13_HUMAN
θ value	4.03905 (rank : 203)	NC score	0.291048 (rank : 100)
Query Neighborhood Hits	244	Target Neighborhood Hits	128	Shared Neighborhood Hits	102
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

SMCA2_HUMAN
θ value	4.03905 (rank : 204)	NC score	0.007281 (rank : 459)
Query Neighborhood Hits	244	Target Neighborhood Hits	503	Shared Neighborhood Hits	22
SwissProt Accessions	P51531	Gene names	SMARCA2, BRM, SNF2A, SNF2L2
Domain Architecture
Description	Probable global transcription activator SNF2L2 (EC 3.6.1.-) (ATP- dependent helicase SMARCA2) (SNF2-alpha) (SWI/SNF-related matrix- associated actin-dependent regulator of chromatin subfamily A member 2) (hBRM).

SNIP1_MOUSE
θ value	4.03905 (rank : 205)	NC score	0.031079 (rank : 441)
Query Neighborhood Hits	244	Target Neighborhood Hits	113	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BIZ6, Q3V106, Q8BIZ4	Gene names	Snip1
Domain Architecture
Description	Smad nuclear-interacting protein 1.

CLCA_MOUSE
θ value	5.27518 (rank : 206)	NC score	0.040111 (rank : 424)
Query Neighborhood Hits	244	Target Neighborhood Hits	106	Shared Neighborhood Hits	12
SwissProt Accessions	O08585	Gene names	Clta
Domain Architecture
Description	Clathrin light chain A (Lca).

CSK_HUMAN
θ value	5.27518 (rank : 207)	NC score	0.093829 (rank : 218)
Query Neighborhood Hits	244	Target Neighborhood Hits	1009	Shared Neighborhood Hits	123
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	5.27518 (rank : 208)	NC score	0.093862 (rank : 217)
Query Neighborhood Hits	244	Target Neighborhood Hits	1009	Shared Neighborhood Hits	123
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

EPS8_MOUSE
θ value	5.27518 (rank : 209)	NC score	0.151886 (rank : 148)
Query Neighborhood Hits	244	Target Neighborhood Hits	157	Shared Neighborhood Hits	108
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

HCK_HUMAN
θ value	5.27518 (rank : 210)	NC score	0.107855 (rank : 195)
Query Neighborhood Hits	244	Target Neighborhood Hits	1035	Shared Neighborhood Hits	145
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

IMA5_HUMAN
θ value	5.27518 (rank : 211)	NC score	0.012940 (rank : 457)
Query Neighborhood Hits	244	Target Neighborhood Hits	68	Shared Neighborhood Hits	3
SwissProt Accessions	O15131	Gene names	KPNA5
Domain Architecture
Description	Importin alpha-6 subunit (Karyopherin alpha-5 subunit).

KLC4_HUMAN
θ value	5.27518 (rank : 212)	NC score	0.020772 (rank : 453)
Query Neighborhood Hits	244	Target Neighborhood Hits	327	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NSK0	Gene names	KLC4, KNSL8
Domain Architecture
Description	Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8).

NFH_HUMAN
θ value	5.27518 (rank : 213)	NC score	0.023218 (rank : 450)
Query Neighborhood Hits	244	Target Neighborhood Hits	1242	Shared Neighborhood Hits	61
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

NOS3_MOUSE
θ value	5.27518 (rank : 214)	NC score	0.007365 (rank : 458)
Query Neighborhood Hits	244	Target Neighborhood Hits	63	Shared Neighborhood Hits	4
SwissProt Accessions	P70313, O55056	Gene names	Nos3, Ecnos
Domain Architecture
Description	Nitric-oxide synthase, endothelial (EC 1.14.13.39) (EC-NOS) (NOS type III) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS).

PININ_HUMAN
θ value	5.27518 (rank : 215)	NC score	0.058874 (rank : 334)
Query Neighborhood Hits	244	Target Neighborhood Hits	753	Shared Neighborhood Hits	52
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

PININ_MOUSE
θ value	5.27518 (rank : 216)	NC score	0.055153 (rank : 358)
Query Neighborhood Hits	244	Target Neighborhood Hits	777	Shared Neighborhood Hits	49
SwissProt Accessions	O35691, Q8CD89, Q8CGU3	Gene names	Pnn
Domain Architecture	No domain graphic available
Description	Pinin.

SDCG8_MOUSE
θ value	5.27518 (rank : 217)	NC score	0.050342 (rank : 408)
Query Neighborhood Hits	244	Target Neighborhood Hits	886	Shared Neighborhood Hits	55
SwissProt Accessions	Q80UF4	Gene names	Sdccag8, Cccap
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (mCCCAP).

SNX9_HUMAN
θ value	5.27518 (rank : 218)	NC score	0.211011 (rank : 124)
Query Neighborhood Hits	244	Target Neighborhood Hits	148	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SNX9_MOUSE
θ value	5.27518 (rank : 219)	NC score	0.193876 (rank : 134)
Query Neighborhood Hits	244	Target Neighborhood Hits	141	Shared Neighborhood Hits	83
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

ANM2_MOUSE
θ value	6.88961 (rank : 220)	NC score	0.198457 (rank : 131)
Query Neighborhood Hits	244	Target Neighborhood Hits	175	Shared Neighborhood Hits	125
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

CCNB3_HUMAN
θ value	6.88961 (rank : 221)	NC score	0.020791 (rank : 452)
Query Neighborhood Hits	244	Target Neighborhood Hits	368	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WWL7, Q96SB5, Q96SB6, Q96SB7, Q9NT38	Gene names	CCNB3, CYCB3
Domain Architecture
Description	G2/mitotic-specific cyclin-B3.

GCP6_HUMAN
θ value	6.88961 (rank : 222)	NC score	0.024572 (rank : 448)
Query Neighborhood Hits	244	Target Neighborhood Hits	295	Shared Neighborhood Hits	23
SwissProt Accessions	Q96RT7, Q5JZ80, Q6PJ40, Q86YE9, Q9BY91, Q9UGX3, Q9UGX4	Gene names	TUBGCP6, GCP6, KIAA1669
Domain Architecture
Description	Gamma-tubulin complex component 6 (GCP-6).

HIP1R_MOUSE
θ value	6.88961 (rank : 223)	NC score	0.038609 (rank : 430)
Query Neighborhood Hits	244	Target Neighborhood Hits	959	Shared Neighborhood Hits	57
SwissProt Accessions	Q9JKY5	Gene names	Hip1r
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related).

K1802_HUMAN
θ value	6.88961 (rank : 224)	NC score	0.005883 (rank : 460)
Query Neighborhood Hits	244	Target Neighborhood Hits	1378	Shared Neighborhood Hits	27
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

LIPS_HUMAN
θ value	6.88961 (rank : 225)	NC score	0.025699 (rank : 446)
Query Neighborhood Hits	244	Target Neighborhood Hits	314	Shared Neighborhood Hits	19
SwissProt Accessions	Q05469, Q3LRT2, Q6NSL7	Gene names	LIPE
Domain Architecture
Description	Hormone-sensitive lipase (EC 3.1.1.79) (HSL).

LRC27_MOUSE
θ value	6.88961 (rank : 226)	NC score	0.030309 (rank : 442)
Query Neighborhood Hits	244	Target Neighborhood Hits	290	Shared Neighborhood Hits	9
SwissProt Accessions	Q80YS5, Q9D6Z2	Gene names	Lrrc27
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 27.

NUCB1_MOUSE
θ value	6.88961 (rank : 227)	NC score	0.041709 (rank : 422)
Query Neighborhood Hits	244	Target Neighborhood Hits	414	Shared Neighborhood Hits	39
SwissProt Accessions	Q02819, Q3TU42, Q9CWA1, Q9D8J4, Q9DBL3	Gene names	Nucb1, Nuc, Nucb
Domain Architecture	No domain graphic available
Description	Nucleobindin-1 precursor (CALNUC).

P85B_HUMAN
θ value	6.88961 (rank : 228)	NC score	0.139862 (rank : 158)
Query Neighborhood Hits	244	Target Neighborhood Hits	543	Shared Neighborhood Hits	91
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

ROCK2_HUMAN
θ value	6.88961 (rank : 229)	NC score	0.028934 (rank : 443)
Query Neighborhood Hits	244	Target Neighborhood Hits	2073	Shared Neighborhood Hits	95
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

SHOX_HUMAN
θ value	6.88961 (rank : 230)	NC score	0.000567 (rank : 463)
Query Neighborhood Hits	244	Target Neighborhood Hits	363	Shared Neighborhood Hits	7
SwissProt Accessions	O15266, O00412, O00413, O15267	Gene names	SHOX, PHOG
Domain Architecture
Description	Short stature homeobox protein (Short stature homeobox-containing protein) (Pseudoautosomal homeobox-containing osteogenic protein).

THUM2_HUMAN
θ value	6.88961 (rank : 231)	NC score	0.031121 (rank : 440)
Query Neighborhood Hits	244	Target Neighborhood Hits	139	Shared Neighborhood Hits	17
SwissProt Accessions	Q9BTF0	Gene names	THUMPD2, C2orf8
Domain Architecture
Description	THUMP domain-containing protein 2.

BCAR1_HUMAN
θ value	8.99809 (rank : 232)	NC score	0.263689 (rank : 105)
Query Neighborhood Hits	244	Target Neighborhood Hits	554	Shared Neighborhood Hits	139
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

GLE1_HUMAN
θ value	8.99809 (rank : 233)	NC score	0.071122 (rank : 277)
Query Neighborhood Hits	244	Target Neighborhood Hits	445	Shared Neighborhood Hits	45
SwissProt Accessions	Q53GS7, O75458, Q53GT9, Q5VVU1, Q8NCP6, Q9UFL6	Gene names	GLE1L, GLE1
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein) (hGLE1).

HCK_MOUSE
θ value	8.99809 (rank : 234)	NC score	0.108483 (rank : 193)
Query Neighborhood Hits	244	Target Neighborhood Hits	1029	Shared Neighborhood Hits	144
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

KTNA1_HUMAN
θ value	8.99809 (rank : 235)	NC score	0.001402 (rank : 462)
Query Neighborhood Hits	244	Target Neighborhood Hits	117	Shared Neighborhood Hits	3
SwissProt Accessions	O75449, Q5TFA8, Q5TFA9, Q86VN2, Q9NU52	Gene names	KATNA1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A1 (EC 3.6.4.3) (Katanin p60 subunit A1) (p60 katanin).

MD1L1_HUMAN
θ value	8.99809 (rank : 236)	NC score	0.042991 (rank : 421)
Query Neighborhood Hits	244	Target Neighborhood Hits	893	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y6D9, Q13312, Q75MI0, Q86UM4, Q9UNH0	Gene names	MAD1L1, MAD1, TXBP181
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1) (Mitotic checkpoint MAD1 protein-homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181).

NCF4_HUMAN
θ value	8.99809 (rank : 237)	NC score	0.398469 (rank : 66)
Query Neighborhood Hits	244	Target Neighborhood Hits	161	Shared Neighborhood Hits	116
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NUCB1_HUMAN
θ value	8.99809 (rank : 238)	NC score	0.036579 (rank : 433)
Query Neighborhood Hits	244	Target Neighborhood Hits	359	Shared Neighborhood Hits	31
SwissProt Accessions	Q02818, Q15838, Q7Z4J7, Q9BUR1	Gene names	NUCB1, NUC
Domain Architecture	No domain graphic available
Description	Nucleobindin-1 precursor (CALNUC).

PPIP2_MOUSE
θ value	8.99809 (rank : 239)	NC score	0.094406 (rank : 216)
Query Neighborhood Hits	244	Target Neighborhood Hits	308	Shared Neighborhood Hits	37
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

PRG4_HUMAN
θ value	8.99809 (rank : 240)	NC score	0.023269 (rank : 449)
Query Neighborhood Hits	244	Target Neighborhood Hits	764	Shared Neighborhood Hits	27
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

SRRM1_HUMAN
θ value	8.99809 (rank : 241)	NC score	0.020008 (rank : 454)
Query Neighborhood Hits	244	Target Neighborhood Hits	690	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

TACC3_HUMAN
θ value	8.99809 (rank : 242)	NC score	0.038438 (rank : 431)
Query Neighborhood Hits	244	Target Neighborhood Hits	779	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

TXK_HUMAN
θ value	8.99809 (rank : 243)	NC score	0.082610 (rank : 238)
Query Neighborhood Hits	244	Target Neighborhood Hits	971	Shared Neighborhood Hits	105
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

ZNF96_HUMAN
θ value	8.99809 (rank : 244)	NC score	-0.008006 (rank : 464)
Query Neighborhood Hits	244	Target Neighborhood Hits	869	Shared Neighborhood Hits	13
SwissProt Accessions	O43309, O43724	Gene names	ZNF96, KIAA0426, ZNF305, ZSCAN12
Domain Architecture
Description	Zinc finger protein 96 (Zinc finger protein 305) (Zinc finger and SCAN domain-containing protein 12).

ABL1_HUMAN
θ value	θ > 10 (rank : 245)	NC score	0.080358 (rank : 247)
Query Neighborhood Hits	244	Target Neighborhood Hits	1220	Shared Neighborhood Hits	119
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	θ > 10 (rank : 246)	NC score	0.081787 (rank : 241)
Query Neighborhood Hits	244	Target Neighborhood Hits	1178	Shared Neighborhood Hits	119
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
θ value	θ > 10 (rank : 247)	NC score	0.076925 (rank : 259)
Query Neighborhood Hits	244	Target Neighborhood Hits	1045	Shared Neighborhood Hits	107
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

AMPH_HUMAN
θ value	θ > 10 (rank : 248)	NC score	0.131690 (rank : 165)
Query Neighborhood Hits	244	Target Neighborhood Hits	455	Shared Neighborhood Hits	87
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

AMPH_MOUSE
θ value	θ > 10 (rank : 249)	NC score	0.127074 (rank : 172)
Query Neighborhood Hits	244	Target Neighborhood Hits	291	Shared Neighborhood Hits	76
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

APS_HUMAN
θ value	θ > 10 (rank : 250)	NC score	0.078495 (rank : 252)
Query Neighborhood Hits	244	Target Neighborhood Hits	162	Shared Neighborhood Hits	38
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

APS_MOUSE
θ value	θ > 10 (rank : 251)	NC score	0.061035 (rank : 314)
Query Neighborhood Hits	244	Target Neighborhood Hits	134	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

ARHG1_HUMAN
θ value	θ > 10 (rank : 252)	NC score	0.074215 (rank : 268)
Query Neighborhood Hits	244	Target Neighborhood Hits	176	Shared Neighborhood Hits	20
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

ARHG1_MOUSE
θ value	θ > 10 (rank : 253)	NC score	0.065303 (rank : 292)
Query Neighborhood Hits	244	Target Neighborhood Hits	266	Shared Neighborhood Hits	16
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

ARHG2_HUMAN
θ value	θ > 10 (rank : 254)	NC score	0.068800 (rank : 283)
Query Neighborhood Hits	244	Target Neighborhood Hits	142	Shared Neighborhood Hits	24
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

ARHG2_MOUSE
θ value	θ > 10 (rank : 255)	NC score	0.068098 (rank : 285)
Query Neighborhood Hits	244	Target Neighborhood Hits	120	Shared Neighborhood Hits	26
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

ARHG3_HUMAN
θ value	θ > 10 (rank : 256)	NC score	0.101724 (rank : 203)
Query Neighborhood Hits	244	Target Neighborhood Hits	82	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 257)	NC score	0.101666 (rank : 204)
Query Neighborhood Hits	244	Target Neighborhood Hits	85	Shared Neighborhood Hits	21
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG5_HUMAN
θ value	θ > 10 (rank : 258)	NC score	0.152440 (rank : 147)
Query Neighborhood Hits	244	Target Neighborhood Hits	172	Shared Neighborhood Hits	80
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG8_HUMAN
θ value	θ > 10 (rank : 259)	NC score	0.093736 (rank : 219)
Query Neighborhood Hits	244	Target Neighborhood Hits	85	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

ARHG8_MOUSE
θ value	θ > 10 (rank : 260)	NC score	0.098763 (rank : 209)
Query Neighborhood Hits	244	Target Neighborhood Hits	79	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

ARHGA_HUMAN
θ value	θ > 10 (rank : 261)	NC score	0.084377 (rank : 235)
Query Neighborhood Hits	244	Target Neighborhood Hits	187	Shared Neighborhood Hits	27
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGA_MOUSE
θ value	θ > 10 (rank : 262)	NC score	0.087050 (rank : 229)
Query Neighborhood Hits	244	Target Neighborhood Hits	125	Shared Neighborhood Hits	24
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

ARHGB_HUMAN
θ value	θ > 10 (rank : 263)	NC score	0.070276 (rank : 278)
Query Neighborhood Hits	244	Target Neighborhood Hits	375	Shared Neighborhood Hits	23
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

ARHGC_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.071812 (rank : 272)
Query Neighborhood Hits	244	Target Neighborhood Hits	351	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGC_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.071398 (rank : 275)
Query Neighborhood Hits	244	Target Neighborhood Hits	344	Shared Neighborhood Hits	28
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

ARHGF_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.062737 (rank : 306)
Query Neighborhood Hits	244	Target Neighborhood Hits	214	Shared Neighborhood Hits	24
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

ARHGG_HUMAN
θ value	θ > 10 (rank : 267)	NC score	0.101614 (rank : 205)
Query Neighborhood Hits	244	Target Neighborhood Hits	129	Shared Neighborhood Hits	40
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 268)	NC score	0.115870 (rank : 184)
Query Neighborhood Hits	244	Target Neighborhood Hits	152	Shared Neighborhood Hits	49
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ASPP2_HUMAN
θ value	θ > 10 (rank : 269)	NC score	0.154991 (rank : 146)
Query Neighborhood Hits	244	Target Neighborhood Hits	1156	Shared Neighborhood Hits	147
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

BAIP2_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.088766 (rank : 226)
Query Neighborhood Hits	244	Target Neighborhood Hits	192	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	θ > 10 (rank : 271)	NC score	0.090344 (rank : 225)
Query Neighborhood Hits	244	Target Neighborhood Hits	185	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BCAR1_MOUSE
θ value	θ > 10 (rank : 272)	NC score	0.258826 (rank : 106)
Query Neighborhood Hits	244	Target Neighborhood Hits	438	Shared Neighborhood Hits	135
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR3_HUMAN
θ value	θ > 10 (rank : 273)	NC score	0.058806 (rank : 336)
Query Neighborhood Hits	244	Target Neighborhood Hits	129	Shared Neighborhood Hits	34
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BCAR3_MOUSE
θ value	θ > 10 (rank : 274)	NC score	0.058806 (rank : 337)
Query Neighborhood Hits	244	Target Neighborhood Hits	127	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

BCR_HUMAN
θ value	θ > 10 (rank : 275)	NC score	0.050079 (rank : 413)
Query Neighborhood Hits	244	Target Neighborhood Hits	204	Shared Neighborhood Hits	25
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

BI2L1_HUMAN
θ value	θ > 10 (rank : 276)	NC score	0.095926 (rank : 213)
Query Neighborhood Hits	244	Target Neighborhood Hits	156	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BI2L1_MOUSE
θ value	θ > 10 (rank : 277)	NC score	0.079109 (rank : 250)
Query Neighborhood Hits	244	Target Neighborhood Hits	197	Shared Neighborhood Hits	54
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

BIN1_HUMAN
θ value	θ > 10 (rank : 278)	NC score	0.111379 (rank : 191)
Query Neighborhood Hits	244	Target Neighborhood Hits	335	Shared Neighborhood Hits	75
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

BIN1_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.111461 (rank : 190)
Query Neighborhood Hits	244	Target Neighborhood Hits	283	Shared Neighborhood Hits	76
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

BLK_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.085505 (rank : 231)
Query Neighborhood Hits	244	Target Neighborhood Hits	994	Shared Neighborhood Hits	120
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLK_MOUSE
θ value	θ > 10 (rank : 281)	NC score	0.081863 (rank : 240)
Query Neighborhood Hits	244	Target Neighborhood Hits	992	Shared Neighborhood Hits	110
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BLNK_HUMAN
θ value	θ > 10 (rank : 282)	NC score	0.056816 (rank : 348)
Query Neighborhood Hits	244	Target Neighborhood Hits	228	Shared Neighborhood Hits	34
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

BLNK_MOUSE
θ value	θ > 10 (rank : 283)	NC score	0.055151 (rank : 359)
Query Neighborhood Hits	244	Target Neighborhood Hits	296	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

CA065_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.057559 (rank : 344)
Query Neighborhood Hits	244	Target Neighborhood Hits	469	Shared Neighborhood Hits	47
SwissProt Accessions	Q8N715, Q8N746, Q8NA93	Gene names	C1orf65
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf65.

CCD21_HUMAN
θ value	θ > 10 (rank : 285)	NC score	0.051349 (rank : 396)
Query Neighborhood Hits	244	Target Neighborhood Hits	1228	Shared Neighborhood Hits	78
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CCD21_MOUSE
θ value	θ > 10 (rank : 286)	NC score	0.051081 (rank : 400)
Query Neighborhood Hits	244	Target Neighborhood Hits	1135	Shared Neighborhood Hits	70
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

CCD46_HUMAN
θ value	θ > 10 (rank : 287)	NC score	0.052440 (rank : 381)
Query Neighborhood Hits	244	Target Neighborhood Hits	1430	Shared Neighborhood Hits	88
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

CDC37_MOUSE
θ value	θ > 10 (rank : 288)	NC score	0.058863 (rank : 335)
Query Neighborhood Hits	244	Target Neighborhood Hits	359	Shared Neighborhood Hits	26
SwissProt Accessions	Q61081, Q3TGP0	Gene names	Cdc37
Domain Architecture
Description	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37).

DAPP1_HUMAN
θ value	θ > 10 (rank : 289)	NC score	0.099042 (rank : 208)
Query Neighborhood Hits	244	Target Neighborhood Hits	227	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

DAPP1_MOUSE
θ value	θ > 10 (rank : 290)	NC score	0.101873 (rank : 202)
Query Neighborhood Hits	244	Target Neighborhood Hits	225	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

ECT2_HUMAN
θ value	θ > 10 (rank : 291)	NC score	0.075343 (rank : 265)
Query Neighborhood Hits	244	Target Neighborhood Hits	98	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

ECT2_MOUSE
θ value	θ > 10 (rank : 292)	NC score	0.077928 (rank : 254)
Query Neighborhood Hits	244	Target Neighborhood Hits	98	Shared Neighborhood Hits	21
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

EFS_HUMAN
θ value	θ > 10 (rank : 293)	NC score	0.245344 (rank : 111)
Query Neighborhood Hits	244	Target Neighborhood Hits	348	Shared Neighborhood Hits	126
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	θ > 10 (rank : 294)	NC score	0.255450 (rank : 109)
Query Neighborhood Hits	244	Target Neighborhood Hits	389	Shared Neighborhood Hits	129
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

EM55_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.071167 (rank : 276)
Query Neighborhood Hits	244	Target Neighborhood Hits	228	Shared Neighborhood Hits	75
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

EM55_MOUSE
θ value	θ > 10 (rank : 296)	NC score	0.069141 (rank : 282)
Query Neighborhood Hits	244	Target Neighborhood Hits	221	Shared Neighborhood Hits	72
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

EP15_HUMAN
θ value	θ > 10 (rank : 297)	NC score	0.052106 (rank : 385)
Query Neighborhood Hits	244	Target Neighborhood Hits	1021	Shared Neighborhood Hits	63
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

EP15_MOUSE
θ value	θ > 10 (rank : 298)	NC score	0.050618 (rank : 406)
Query Neighborhood Hits	244	Target Neighborhood Hits	820	Shared Neighborhood Hits	50
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

ES8L1_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.138220 (rank : 161)
Query Neighborhood Hits	244	Target Neighborhood Hits	162	Shared Neighborhood Hits	91
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_MOUSE
θ value	θ > 10 (rank : 300)	NC score	0.131474 (rank : 166)
Query Neighborhood Hits	244	Target Neighborhood Hits	143	Shared Neighborhood Hits	79
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L2_HUMAN
θ value	θ > 10 (rank : 301)	NC score	0.160993 (rank : 142)
Query Neighborhood Hits	244	Target Neighborhood Hits	193	Shared Neighborhood Hits	107
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L2_MOUSE
θ value	θ > 10 (rank : 302)	NC score	0.148229 (rank : 152)
Query Neighborhood Hits	244	Target Neighborhood Hits	169	Shared Neighborhood Hits	107
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

ES8L3_MOUSE
θ value	θ > 10 (rank : 303)	NC score	0.191144 (rank : 136)
Query Neighborhood Hits	244	Target Neighborhood Hits	168	Shared Neighborhood Hits	118
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

FARP2_MOUSE
θ value	θ > 10 (rank : 304)	NC score	0.052823 (rank : 377)
Query Neighborhood Hits	244	Target Neighborhood Hits	209	Shared Neighborhood Hits	24
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

FER_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.051483 (rank : 395)
Query Neighborhood Hits	244	Target Neighborhood Hits	1278	Shared Neighborhood Hits	85
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

FGD1_HUMAN
θ value	θ > 10 (rank : 306)	NC score	0.053219 (rank : 375)
Query Neighborhood Hits	244	Target Neighborhood Hits	367	Shared Neighborhood Hits	26
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD1_MOUSE
θ value	θ > 10 (rank : 307)	NC score	0.051855 (rank : 390)
Query Neighborhood Hits	244	Target Neighborhood Hits	387	Shared Neighborhood Hits	23
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

FGD2_HUMAN
θ value	θ > 10 (rank : 308)	NC score	0.061971 (rank : 309)
Query Neighborhood Hits	244	Target Neighborhood Hits	151	Shared Neighborhood Hits	21
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

FGD2_MOUSE
θ value	θ > 10 (rank : 309)	NC score	0.058923 (rank : 333)
Query Neighborhood Hits	244	Target Neighborhood Hits	163	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

FGD3_HUMAN
θ value	θ > 10 (rank : 310)	NC score	0.060187 (rank : 320)
Query Neighborhood Hits	244	Target Neighborhood Hits	249	Shared Neighborhood Hits	18
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

FGD3_MOUSE
θ value	θ > 10 (rank : 311)	NC score	0.065120 (rank : 293)
Query Neighborhood Hits	244	Target Neighborhood Hits	257	Shared Neighborhood Hits	21
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

FGD4_HUMAN
θ value	θ > 10 (rank : 312)	NC score	0.064607 (rank : 297)
Query Neighborhood Hits	244	Target Neighborhood Hits	219	Shared Neighborhood Hits	30
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

FGD4_MOUSE
θ value	θ > 10 (rank : 313)	NC score	0.063560 (rank : 302)
Query Neighborhood Hits	244	Target Neighborhood Hits	227	Shared Neighborhood Hits	27
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

FGD6_MOUSE
θ value	θ > 10 (rank : 314)	NC score	0.051706 (rank : 392)
Query Neighborhood Hits	244	Target Neighborhood Hits	282	Shared Neighborhood Hits	31
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

FLIP1_HUMAN
θ value	θ > 10 (rank : 315)	NC score	0.050256 (rank : 411)
Query Neighborhood Hits	244	Target Neighborhood Hits	1405	Shared Neighborhood Hits	83
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

FNBP2_HUMAN
θ value	θ > 10 (rank : 316)	NC score	0.159600 (rank : 143)
Query Neighborhood Hits	244	Target Neighborhood Hits	432	Shared Neighborhood Hits	144
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

FUT8_HUMAN
θ value	θ > 10 (rank : 317)	NC score	0.057060 (rank : 347)
Query Neighborhood Hits	244	Target Neighborhood Hits	67	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

FUT8_MOUSE
θ value	θ > 10 (rank : 318)	NC score	0.054745 (rank : 365)
Query Neighborhood Hits	244	Target Neighborhood Hits	115	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WTS2, Q921U1	Gene names	Fut8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

GAS7_HUMAN
θ value	θ > 10 (rank : 319)	NC score	0.055042 (rank : 361)
Query Neighborhood Hits	244	Target Neighborhood Hits	258	Shared Neighborhood Hits	29
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

GNRP_HUMAN
θ value	θ > 10 (rank : 320)	NC score	0.059548 (rank : 326)
Query Neighborhood Hits	244	Target Neighborhood Hits	239	Shared Neighborhood Hits	24
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

GNRP_MOUSE
θ value	θ > 10 (rank : 321)	NC score	0.064928 (rank : 295)
Query Neighborhood Hits	244	Target Neighborhood Hits	191	Shared Neighborhood Hits	23
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

GRB10_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.060010 (rank : 323)
Query Neighborhood Hits	244	Target Neighborhood Hits	147	Shared Neighborhood Hits	37
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

GRB10_MOUSE
θ value	θ > 10 (rank : 323)	NC score	0.060680 (rank : 318)
Query Neighborhood Hits	244	Target Neighborhood Hits	156	Shared Neighborhood Hits	39
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GRB14_HUMAN
θ value	θ > 10 (rank : 324)	NC score	0.077027 (rank : 258)
Query Neighborhood Hits	244	Target Neighborhood Hits	137	Shared Neighborhood Hits	40
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB14_MOUSE
θ value	θ > 10 (rank : 325)	NC score	0.078668 (rank : 251)
Query Neighborhood Hits	244	Target Neighborhood Hits	149	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

GRB7_HUMAN
θ value	θ > 10 (rank : 326)	NC score	0.063455 (rank : 304)
Query Neighborhood Hits	244	Target Neighborhood Hits	156	Shared Neighborhood Hits	40
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

GRB7_MOUSE
θ value	θ > 10 (rank : 327)	NC score	0.069534 (rank : 280)
Query Neighborhood Hits	244	Target Neighborhood Hits	157	Shared Neighborhood Hits	43
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

HAPIP_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.078083 (rank : 253)
Query Neighborhood Hits	244	Target Neighborhood Hits	350	Shared Neighborhood Hits	40
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

HGS_HUMAN
θ value	θ > 10 (rank : 329)	NC score	0.056167 (rank : 353)
Query Neighborhood Hits	244	Target Neighborhood Hits	517	Shared Neighborhood Hits	29
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

HGS_MOUSE
θ value	θ > 10 (rank : 330)	NC score	0.055147 (rank : 360)
Query Neighborhood Hits	244	Target Neighborhood Hits	589	Shared Neighborhood Hits	30
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

HSH2D_HUMAN
θ value	θ > 10 (rank : 331)	NC score	0.076539 (rank : 260)
Query Neighborhood Hits	244	Target Neighborhood Hits	159	Shared Neighborhood Hits	36
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

HSH2D_MOUSE
θ value	θ > 10 (rank : 332)	NC score	0.058935 (rank : 332)
Query Neighborhood Hits	244	Target Neighborhood Hits	124	Shared Neighborhood Hits	28
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

IDLC_HUMAN
θ value	θ > 10 (rank : 333)	NC score	0.052215 (rank : 383)
Query Neighborhood Hits	244	Target Neighborhood Hits	348	Shared Neighborhood Hits	29
SwissProt Accessions	O14645, Q5TGH0, Q7L0I5	Gene names	DNALI1
Domain Architecture	No domain graphic available
Description	Axonemal dynein light intermediate polypeptide 1 (Inner dynein arm light chain, axonemal) (hp28).

IDLC_MOUSE
θ value	θ > 10 (rank : 334)	NC score	0.051568 (rank : 394)
Query Neighborhood Hits	244	Target Neighborhood Hits	321	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BVN8	Gene names	Dnali1
Domain Architecture	No domain graphic available
Description	Axonemal dynein light intermediate polypeptide 1 (Inner dynein arm light chain, axonemal).

IF3A_HUMAN
θ value	θ > 10 (rank : 335)	NC score	0.053614 (rank : 373)
Query Neighborhood Hits	244	Target Neighborhood Hits	875	Shared Neighborhood Hits	72
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

IF3A_MOUSE
θ value	θ > 10 (rank : 336)	NC score	0.054854 (rank : 362)
Query Neighborhood Hits	244	Target Neighborhood Hits	871	Shared Neighborhood Hits	73
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

INCE_HUMAN
θ value	θ > 10 (rank : 337)	NC score	0.050305 (rank : 409)
Query Neighborhood Hits	244	Target Neighborhood Hits	978	Shared Neighborhood Hits	82
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

INCE_MOUSE
θ value	θ > 10 (rank : 338)	NC score	0.052161 (rank : 384)
Query Neighborhood Hits	244	Target Neighborhood Hits	903	Shared Neighborhood Hits	83
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

JIP1_HUMAN
θ value	θ > 10 (rank : 339)	NC score	0.058476 (rank : 340)
Query Neighborhood Hits	244	Target Neighborhood Hits	271	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP1_MOUSE
θ value	θ > 10 (rank : 340)	NC score	0.056168 (rank : 352)
Query Neighborhood Hits	244	Target Neighborhood Hits	259	Shared Neighborhood Hits	47
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

JIP2_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.068278 (rank : 284)
Query Neighborhood Hits	244	Target Neighborhood Hits	288	Shared Neighborhood Hits	50
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

JIP2_MOUSE
θ value	θ > 10 (rank : 342)	NC score	0.067478 (rank : 288)
Query Neighborhood Hits	244	Target Neighborhood Hits	144	Shared Neighborhood Hits	48
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

LBC_HUMAN
θ value	θ > 10 (rank : 343)	NC score	0.071626 (rank : 274)
Query Neighborhood Hits	244	Target Neighborhood Hits	90	Shared Neighborhood Hits	22
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

LCK_HUMAN
θ value	θ > 10 (rank : 344)	NC score	0.080523 (rank : 246)
Query Neighborhood Hits	244	Target Neighborhood Hits	987	Shared Neighborhood Hits	102
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

LCK_MOUSE
θ value	θ > 10 (rank : 345)	NC score	0.079796 (rank : 249)
Query Neighborhood Hits	244	Target Neighborhood Hits	981	Shared Neighborhood Hits	102
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

LCP2_HUMAN
θ value	θ > 10 (rank : 346)	NC score	0.058332 (rank : 341)
Query Neighborhood Hits	244	Target Neighborhood Hits	531	Shared Neighborhood Hits	51
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LCP2_MOUSE
θ value	θ > 10 (rank : 347)	NC score	0.066532 (rank : 289)
Query Neighborhood Hits	244	Target Neighborhood Hits	177	Shared Neighborhood Hits	38
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LNK_HUMAN
θ value	θ > 10 (rank : 348)	NC score	0.069500 (rank : 281)
Query Neighborhood Hits	244	Target Neighborhood Hits	151	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LNK_MOUSE
θ value	θ > 10 (rank : 349)	NC score	0.069987 (rank : 279)
Query Neighborhood Hits	244	Target Neighborhood Hits	132	Shared Neighborhood Hits	34
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

LYN_HUMAN
θ value	θ > 10 (rank : 350)	NC score	0.094795 (rank : 214)
Query Neighborhood Hits	244	Target Neighborhood Hits	1022	Shared Neighborhood Hits	131
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_MOUSE
θ value	θ > 10 (rank : 351)	NC score	0.094459 (rank : 215)
Query Neighborhood Hits	244	Target Neighborhood Hits	1023	Shared Neighborhood Hits	130
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

MATK_HUMAN
θ value	θ > 10 (rank : 352)	NC score	0.054699 (rank : 367)
Query Neighborhood Hits	244	Target Neighborhood Hits	954	Shared Neighborhood Hits	66
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MATK_MOUSE
θ value	θ > 10 (rank : 353)	NC score	0.055383 (rank : 355)
Query Neighborhood Hits	244	Target Neighborhood Hits	952	Shared Neighborhood Hits	71
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MCF2L_MOUSE
θ value	θ > 10 (rank : 354)	NC score	0.097255 (rank : 211)
Query Neighborhood Hits	244	Target Neighborhood Hits	255	Shared Neighborhood Hits	45
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MCF2_HUMAN
θ value	θ > 10 (rank : 355)	NC score	0.087986 (rank : 228)
Query Neighborhood Hits	244	Target Neighborhood Hits	166	Shared Neighborhood Hits	29
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

MPP6_HUMAN
θ value	θ > 10 (rank : 356)	NC score	0.057350 (rank : 346)
Query Neighborhood Hits	244	Target Neighborhood Hits	180	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

MPP6_MOUSE
θ value	θ > 10 (rank : 357)	NC score	0.053827 (rank : 370)
Query Neighborhood Hits	244	Target Neighborhood Hits	187	Shared Neighborhood Hits	58
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

MY18A_HUMAN
θ value	θ > 10 (rank : 358)	NC score	0.061229 (rank : 313)
Query Neighborhood Hits	244	Target Neighborhood Hits	1929	Shared Neighborhood Hits	100
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MY18A_MOUSE
θ value	θ > 10 (rank : 359)	NC score	0.059104 (rank : 331)
Query Neighborhood Hits	244	Target Neighborhood Hits	1989	Shared Neighborhood Hits	101
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

MYH11_HUMAN
θ value	θ > 10 (rank : 360)	NC score	0.062140 (rank : 308)
Query Neighborhood Hits	244	Target Neighborhood Hits	1806	Shared Neighborhood Hits	99
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH11_MOUSE
θ value	θ > 10 (rank : 361)	NC score	0.060023 (rank : 322)
Query Neighborhood Hits	244	Target Neighborhood Hits	1777	Shared Neighborhood Hits	96
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

MYH13_HUMAN
θ value	θ > 10 (rank : 362)	NC score	0.050984 (rank : 402)
Query Neighborhood Hits	244	Target Neighborhood Hits	1504	Shared Neighborhood Hits	84
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

MYH14_MOUSE
θ value	θ > 10 (rank : 363)	NC score	0.050027 (rank : 416)
Query Neighborhood Hits	244	Target Neighborhood Hits	1225	Shared Neighborhood Hits	71
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

MYH1_HUMAN
θ value	θ > 10 (rank : 364)	NC score	0.052786 (rank : 378)
Query Neighborhood Hits	244	Target Neighborhood Hits	1478	Shared Neighborhood Hits	85
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

MYH1_MOUSE
θ value	θ > 10 (rank : 365)	NC score	0.054704 (rank : 366)
Query Neighborhood Hits	244	Target Neighborhood Hits	1461	Shared Neighborhood Hits	86
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

MYH2_HUMAN
θ value	θ > 10 (rank : 366)	NC score	0.055201 (rank : 356)
Query Neighborhood Hits	244	Target Neighborhood Hits	1491	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

MYH3_HUMAN
θ value	θ > 10 (rank : 367)	NC score	0.054579 (rank : 368)
Query Neighborhood Hits	244	Target Neighborhood Hits	1660	Shared Neighborhood Hits	92
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

MYH4_MOUSE
θ value	θ > 10 (rank : 368)	NC score	0.050982 (rank : 403)
Query Neighborhood Hits	244	Target Neighborhood Hits	1476	Shared Neighborhood Hits	86
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

MYH6_MOUSE
θ value	θ > 10 (rank : 369)	NC score	0.050257 (rank : 410)
Query Neighborhood Hits	244	Target Neighborhood Hits	1501	Shared Neighborhood Hits	83
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

MYH7_HUMAN
θ value	θ > 10 (rank : 370)	NC score	0.051211 (rank : 399)
Query Neighborhood Hits	244	Target Neighborhood Hits	1559	Shared Neighborhood Hits	83
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

MYH8_HUMAN
θ value	θ > 10 (rank : 371)	NC score	0.052384 (rank : 382)
Query Neighborhood Hits	244	Target Neighborhood Hits	1610	Shared Neighborhood Hits	91
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYH8_MOUSE
θ value	θ > 10 (rank : 372)	NC score	0.053823 (rank : 371)
Query Neighborhood Hits	244	Target Neighborhood Hits	1600	Shared Neighborhood Hits	91
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

MYO10_HUMAN
θ value	θ > 10 (rank : 373)	NC score	0.051815 (rank : 391)
Query Neighborhood Hits	244	Target Neighborhood Hits	920	Shared Neighborhood Hits	71
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

MYO5C_HUMAN
θ value	θ > 10 (rank : 374)	NC score	0.052905 (rank : 376)
Query Neighborhood Hits	244	Target Neighborhood Hits	1206	Shared Neighborhood Hits	68
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

NCF1_HUMAN
θ value	θ > 10 (rank : 375)	NC score	0.337353 (rank : 85)
Query Neighborhood Hits	244	Target Neighborhood Hits	198	Shared Neighborhood Hits	129
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NGEF_HUMAN
θ value	θ > 10 (rank : 376)	NC score	0.132470 (rank : 163)
Query Neighborhood Hits	244	Target Neighborhood Hits	166	Shared Neighborhood Hits	68
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 377)	NC score	0.132214 (rank : 164)
Query Neighborhood Hits	244	Target Neighborhood Hits	228	Shared Neighborhood Hits	75
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NOXO1_HUMAN
θ value	θ > 10 (rank : 378)	NC score	0.164388 (rank : 140)
Query Neighborhood Hits	244	Target Neighborhood Hits	100	Shared Neighborhood Hits	77
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 379)	NC score	0.216431 (rank : 119)
Query Neighborhood Hits	244	Target Neighborhood Hits	114	Shared Neighborhood Hits	88
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NRAP_HUMAN
θ value	θ > 10 (rank : 380)	NC score	0.090421 (rank : 224)
Query Neighborhood Hits	244	Target Neighborhood Hits	159	Shared Neighborhood Hits	7
SwissProt Accessions	Q86VF7, O15500, Q5VWI3, Q5VWI4, Q6MZK3, Q6N026, Q6N059, Q6NSH8, Q6PDB0, Q719H6, Q86TC5, Q86TD6, Q86TE6, Q86VF6, Q8N3R6, Q8N8F9, Q8TCH0, Q96MG4	Gene names	NRAP
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

NRAP_MOUSE
θ value	θ > 10 (rank : 381)	NC score	0.091850 (rank : 222)
Query Neighborhood Hits	244	Target Neighborhood Hits	167	Shared Neighborhood Hits	9
SwissProt Accessions	Q80XB4, O35884, Q3UTY7, Q3UU10, Q80V40	Gene names	Nrap
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

P55G_HUMAN
θ value	θ > 10 (rank : 382)	NC score	0.105439 (rank : 197)
Query Neighborhood Hits	244	Target Neighborhood Hits	451	Shared Neighborhood Hits	71
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P55G_MOUSE
θ value	θ > 10 (rank : 383)	NC score	0.102224 (rank : 200)
Query Neighborhood Hits	244	Target Neighborhood Hits	401	Shared Neighborhood Hits	67
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

P85B_MOUSE
θ value	θ > 10 (rank : 384)	NC score	0.129729 (rank : 168)
Query Neighborhood Hits	244	Target Neighborhood Hits	519	Shared Neighborhood Hits	87
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

PKHG1_HUMAN
θ value	θ > 10 (rank : 385)	NC score	0.108095 (rank : 194)
Query Neighborhood Hits	244	Target Neighborhood Hits	174	Shared Neighborhood Hits	24
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

PKHG4_HUMAN
θ value	θ > 10 (rank : 386)	NC score	0.050145 (rank : 412)
Query Neighborhood Hits	244	Target Neighborhood Hits	200	Shared Neighborhood Hits	17
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

PLCB1_HUMAN
θ value	θ > 10 (rank : 387)	NC score	0.058527 (rank : 339)
Query Neighborhood Hits	244	Target Neighborhood Hits	614	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NQ66, O60325, Q5TFF7, Q5TGC9, Q8IV93, Q9BQW2, Q9H4H2, Q9H8H5, Q9NQ65, Q9NQH9, Q9NTH4, Q9UJP6, Q9UM26	Gene names	PLCB1, KIAA0581
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

PLCB1_MOUSE
θ value	θ > 10 (rank : 388)	NC score	0.055175 (rank : 357)
Query Neighborhood Hits	244	Target Neighborhood Hits	531	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Z1B3, Q62075, Q8K5A5, Q8K5A6, Q9Z0E5, Q9Z2T5	Gene names	Plcb1, Plcb
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

PLCB2_HUMAN
θ value	θ > 10 (rank : 389)	NC score	0.067654 (rank : 286)
Query Neighborhood Hits	244	Target Neighborhood Hits	608	Shared Neighborhood Hits	53
SwissProt Accessions	Q00722	Gene names	PLCB2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-2) (PLC-beta-2).

PLCB4_HUMAN
θ value	θ > 10 (rank : 390)	NC score	0.064209 (rank : 300)
Query Neighborhood Hits	244	Target Neighborhood Hits	658	Shared Neighborhood Hits	48
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

PLCD1_MOUSE
θ value	θ > 10 (rank : 391)	NC score	0.051979 (rank : 388)
Query Neighborhood Hits	244	Target Neighborhood Hits	106	Shared Neighborhood Hits	12
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

PPIP2_HUMAN
θ value	θ > 10 (rank : 392)	NC score	0.102039 (rank : 201)
Query Neighborhood Hits	244	Target Neighborhood Hits	254	Shared Neighborhood Hits	31
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

PREX1_HUMAN
θ value	θ > 10 (rank : 393)	NC score	0.104475 (rank : 198)
Query Neighborhood Hits	244	Target Neighborhood Hits	177	Shared Neighborhood Hits	22
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

PTK6_HUMAN
θ value	θ > 10 (rank : 394)	NC score	0.080355 (rank : 248)
Query Neighborhood Hits	244	Target Neighborhood Hits	1020	Shared Neighborhood Hits	134
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

PTK6_MOUSE
θ value	θ > 10 (rank : 395)	NC score	0.082705 (rank : 237)
Query Neighborhood Hits	244	Target Neighborhood Hits	1026	Shared Neighborhood Hits	131
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

PTN11_HUMAN
θ value	θ > 10 (rank : 396)	NC score	0.060902 (rank : 317)
Query Neighborhood Hits	244	Target Neighborhood Hits	227	Shared Neighborhood Hits	48
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

PTN11_MOUSE
θ value	θ > 10 (rank : 397)	NC score	0.060911 (rank : 316)
Query Neighborhood Hits	244	Target Neighborhood Hits	227	Shared Neighborhood Hits	48
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN6_MOUSE
θ value	θ > 10 (rank : 398)	NC score	0.051675 (rank : 393)
Query Neighborhood Hits	244	Target Neighborhood Hits	225	Shared Neighborhood Hits	48
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

RASA1_HUMAN
θ value	θ > 10 (rank : 399)	NC score	0.116280 (rank : 183)
Query Neighborhood Hits	244	Target Neighborhood Hits	258	Shared Neighborhood Hits	58
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

RB6I2_HUMAN
θ value	θ > 10 (rank : 400)	NC score	0.050836 (rank : 405)
Query Neighborhood Hits	244	Target Neighborhood Hits	1584	Shared Neighborhood Hits	83
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

RHG04_HUMAN
θ value	θ > 10 (rank : 401)	NC score	0.193609 (rank : 135)
Query Neighborhood Hits	244	Target Neighborhood Hits	307	Shared Neighborhood Hits	137
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RIMB1_HUMAN
θ value	θ > 10 (rank : 402)	NC score	0.134182 (rank : 162)
Query Neighborhood Hits	244	Target Neighborhood Hits	1479	Shared Neighborhood Hits	158
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB1_MOUSE
θ value	θ > 10 (rank : 403)	NC score	0.139361 (rank : 159)
Query Neighborhood Hits	244	Target Neighborhood Hits	1376	Shared Neighborhood Hits	173
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB2_HUMAN
θ value	θ > 10 (rank : 404)	NC score	0.208114 (rank : 126)
Query Neighborhood Hits	244	Target Neighborhood Hits	263	Shared Neighborhood Hits	106
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RIMB2_MOUSE
θ value	θ > 10 (rank : 405)	NC score	0.199817 (rank : 129)
Query Neighborhood Hits	244	Target Neighborhood Hits	246	Shared Neighborhood Hits	98
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RUSC2_HUMAN
θ value	θ > 10 (rank : 406)	NC score	0.081017 (rank : 245)
Query Neighborhood Hits	244	Target Neighborhood Hits	205	Shared Neighborhood Hits	50
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

RUSC2_MOUSE
θ value	θ > 10 (rank : 407)	NC score	0.077831 (rank : 256)
Query Neighborhood Hits	244	Target Neighborhood Hits	305	Shared Neighborhood Hits	58
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SAMN1_HUMAN
θ value	θ > 10 (rank : 408)	NC score	0.057648 (rank : 343)
Query Neighborhood Hits	244	Target Neighborhood Hits	74	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

SAMN1_MOUSE
θ value	θ > 10 (rank : 409)	NC score	0.053687 (rank : 372)
Query Neighborhood Hits	244	Target Neighborhood Hits	69	Shared Neighborhood Hits	36
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

SASH1_HUMAN
θ value	θ > 10 (rank : 410)	NC score	0.059258 (rank : 329)
Query Neighborhood Hits	244	Target Neighborhood Hits	292	Shared Neighborhood Hits	53
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SASH1_MOUSE
θ value	θ > 10 (rank : 411)	NC score	0.054556 (rank : 369)
Query Neighborhood Hits	244	Target Neighborhood Hits	263	Shared Neighborhood Hits	50
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

SH21A_HUMAN
θ value	θ > 10 (rank : 412)	NC score	0.064407 (rank : 299)
Query Neighborhood Hits	244	Target Neighborhood Hits	89	Shared Neighborhood Hits	31
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

SH21A_MOUSE
θ value	θ > 10 (rank : 413)	NC score	0.064064 (rank : 301)
Query Neighborhood Hits	244	Target Neighborhood Hits	89	Shared Neighborhood Hits	30
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

SH21B_HUMAN
θ value	θ > 10 (rank : 414)	NC score	0.076436 (rank : 261)
Query Neighborhood Hits	244	Target Neighborhood Hits	101	Shared Neighborhood Hits	33
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH21B_MOUSE
θ value	θ > 10 (rank : 415)	NC score	0.077882 (rank : 255)
Query Neighborhood Hits	244	Target Neighborhood Hits	101	Shared Neighborhood Hits	32
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SH22A_HUMAN
θ value	θ > 10 (rank : 416)	NC score	0.061587 (rank : 311)
Query Neighborhood Hits	244	Target Neighborhood Hits	144	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SH22A_MOUSE
θ value	θ > 10 (rank : 417)	NC score	0.065507 (rank : 291)
Query Neighborhood Hits	244	Target Neighborhood Hits	179	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

SH24A_HUMAN
θ value	θ > 10 (rank : 418)	NC score	0.086776 (rank : 230)
Query Neighborhood Hits	244	Target Neighborhood Hits	455	Shared Neighborhood Hits	63
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

SH24A_MOUSE
θ value	θ > 10 (rank : 419)	NC score	0.051222 (rank : 397)
Query Neighborhood Hits	244	Target Neighborhood Hits	326	Shared Neighborhood Hits	43
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

SH2D3_HUMAN
θ value	θ > 10 (rank : 420)	NC score	0.062441 (rank : 307)
Query Neighborhood Hits	244	Target Neighborhood Hits	188	Shared Neighborhood Hits	38
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

SH2D3_MOUSE
θ value	θ > 10 (rank : 421)	NC score	0.063503 (rank : 303)
Query Neighborhood Hits	244	Target Neighborhood Hits	174	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

SHAN1_HUMAN
θ value	θ > 10 (rank : 422)	NC score	0.111633 (rank : 188)
Query Neighborhood Hits	244	Target Neighborhood Hits	1041	Shared Neighborhood Hits	113
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SHB_HUMAN
θ value	θ > 10 (rank : 423)	NC score	0.081285 (rank : 244)
Query Neighborhood Hits	244	Target Neighborhood Hits	141	Shared Neighborhood Hits	44
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHB_MOUSE
θ value	θ > 10 (rank : 424)	NC score	0.083920 (rank : 236)
Query Neighborhood Hits	244	Target Neighborhood Hits	137	Shared Neighborhood Hits	44
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

SHC1_HUMAN
θ value	θ > 10 (rank : 425)	NC score	0.074917 (rank : 266)
Query Neighborhood Hits	244	Target Neighborhood Hits	170	Shared Neighborhood Hits	44
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC1_MOUSE
θ value	θ > 10 (rank : 426)	NC score	0.077466 (rank : 257)
Query Neighborhood Hits	244	Target Neighborhood Hits	180	Shared Neighborhood Hits	46
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
θ value	θ > 10 (rank : 427)	NC score	0.074276 (rank : 267)
Query Neighborhood Hits	244	Target Neighborhood Hits	170	Shared Neighborhood Hits	44
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

SHC2_MOUSE
θ value	θ > 10 (rank : 428)	NC score	0.075989 (rank : 264)
Query Neighborhood Hits	244	Target Neighborhood Hits	144	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

SHC3_HUMAN
θ value	θ > 10 (rank : 429)	NC score	0.076347 (rank : 262)
Query Neighborhood Hits	244	Target Neighborhood Hits	155	Shared Neighborhood Hits	41
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

SHC3_MOUSE
θ value	θ > 10 (rank : 430)	NC score	0.082107 (rank : 239)
Query Neighborhood Hits	244	Target Neighborhood Hits	151	Shared Neighborhood Hits	45
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

SHD_HUMAN
θ value	θ > 10 (rank : 431)	NC score	0.072141 (rank : 271)
Query Neighborhood Hits	244	Target Neighborhood Hits	204	Shared Neighborhood Hits	39
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHD_MOUSE
θ value	θ > 10 (rank : 432)	NC score	0.074140 (rank : 269)
Query Neighborhood Hits	244	Target Neighborhood Hits	137	Shared Neighborhood Hits	45
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

SHE_HUMAN
θ value	θ > 10 (rank : 433)	NC score	0.085041 (rank : 234)
Query Neighborhood Hits	244	Target Neighborhood Hits	164	Shared Neighborhood Hits	45
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SHE_MOUSE
θ value	θ > 10 (rank : 434)	NC score	0.088521 (rank : 227)
Query Neighborhood Hits	244	Target Neighborhood Hits	169	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

SLAP1_HUMAN
θ value	θ > 10 (rank : 435)	NC score	0.112487 (rank : 187)
Query Neighborhood Hits	244	Target Neighborhood Hits	113	Shared Neighborhood Hits	43
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SLAP1_MOUSE
θ value	θ > 10 (rank : 436)	NC score	0.111601 (rank : 189)
Query Neighborhood Hits	244	Target Neighborhood Hits	117	Shared Neighborhood Hits	42
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

SLAP2_HUMAN
θ value	θ > 10 (rank : 437)	NC score	0.122883 (rank : 179)
Query Neighborhood Hits	244	Target Neighborhood Hits	139	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

SLAP2_MOUSE
θ value	θ > 10 (rank : 438)	NC score	0.124858 (rank : 176)
Query Neighborhood Hits	244	Target Neighborhood Hits	136	Shared Neighborhood Hits	52
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

SLY_HUMAN
θ value	θ > 10 (rank : 439)	NC score	0.085314 (rank : 232)
Query Neighborhood Hits	244	Target Neighborhood Hits	81	Shared Neighborhood Hits	49
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SLY_MOUSE
θ value	θ > 10 (rank : 440)	NC score	0.100670 (rank : 206)
Query Neighborhood Hits	244	Target Neighborhood Hits	108	Shared Neighborhood Hits	54
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SM1L2_HUMAN
θ value	θ > 10 (rank : 441)	NC score	0.054827 (rank : 363)
Query Neighborhood Hits	244	Target Neighborhood Hits	1019	Shared Neighborhood Hits	67
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

SMC1A_HUMAN
θ value	θ > 10 (rank : 442)	NC score	0.061304 (rank : 312)
Query Neighborhood Hits	244	Target Neighborhood Hits	1346	Shared Neighborhood Hits	81
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

SOCS7_MOUSE
θ value	θ > 10 (rank : 443)	NC score	0.052635 (rank : 379)
Query Neighborhood Hits	244	Target Neighborhood Hits	154	Shared Neighborhood Hits	37
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

SPN90_HUMAN
θ value	θ > 10 (rank : 444)	NC score	0.164249 (rank : 141)
Query Neighborhood Hits	244	Target Neighborhood Hits	157	Shared Neighborhood Hits	81
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 445)	NC score	0.144503 (rank : 155)
Query Neighborhood Hits	244	Target Neighborhood Hits	157	Shared Neighborhood Hits	73
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRGP1_HUMAN
θ value	θ > 10 (rank : 446)	NC score	0.157993 (rank : 144)
Query Neighborhood Hits	244	Target Neighborhood Hits	390	Shared Neighborhood Hits	135
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_HUMAN
θ value	θ > 10 (rank : 447)	NC score	0.166929 (rank : 139)
Query Neighborhood Hits	244	Target Neighborhood Hits	331	Shared Neighborhood Hits	133
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
θ value	θ > 10 (rank : 448)	NC score	0.168795 (rank : 138)
Query Neighborhood Hits	244	Target Neighborhood Hits	324	Shared Neighborhood Hits	136
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SRMS_HUMAN
θ value	θ > 10 (rank : 449)	NC score	0.055849 (rank : 354)
Query Neighborhood Hits	244	Target Neighborhood Hits	946	Shared Neighborhood Hits	70
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

SRMS_MOUSE
θ value	θ > 10 (rank : 450)	NC score	0.064951 (rank : 294)
Query Neighborhood Hits	244	Target Neighborhood Hits	964	Shared Neighborhood Hits	92
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

STS1_HUMAN
θ value	θ > 10 (rank : 451)	NC score	0.115098 (rank : 185)
Query Neighborhood Hits	244	Target Neighborhood Hits	106	Shared Neighborhood Hits	64
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_MOUSE
θ value	θ > 10 (rank : 452)	NC score	0.117707 (rank : 182)
Query Neighborhood Hits	244	Target Neighborhood Hits	104	Shared Neighborhood Hits	65
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS2_HUMAN
θ value	θ > 10 (rank : 453)	NC score	0.140084 (rank : 157)
Query Neighborhood Hits	244	Target Neighborhood Hits	108	Shared Neighborhood Hits	71
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

TCGAP_HUMAN
θ value	θ > 10 (rank : 454)	NC score	0.126606 (rank : 173)
Query Neighborhood Hits	244	Target Neighborhood Hits	872	Shared Neighborhood Hits	108
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 455)	NC score	0.142151 (rank : 156)
Query Neighborhood Hits	244	Target Neighborhood Hits	409	Shared Neighborhood Hits	104
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCRG1_HUMAN
θ value	θ > 10 (rank : 456)	NC score	0.052092 (rank : 386)
Query Neighborhood Hits	244	Target Neighborhood Hits	929	Shared Neighborhood Hits	54
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

TCRG1_MOUSE
θ value	θ > 10 (rank : 457)	NC score	0.051982 (rank : 387)
Query Neighborhood Hits	244	Target Neighborhood Hits	947	Shared Neighborhood Hits	54
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

TIAM1_HUMAN
θ value	θ > 10 (rank : 458)	NC score	0.098376 (rank : 210)
Query Neighborhood Hits	244	Target Neighborhood Hits	225	Shared Neighborhood Hits	26
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TIAM1_MOUSE
θ value	θ > 10 (rank : 459)	NC score	0.100130 (rank : 207)
Query Neighborhood Hits	244	Target Neighborhood Hits	205	Shared Neighborhood Hits	25
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

TOM1_HUMAN
θ value	θ > 10 (rank : 460)	NC score	0.059348 (rank : 327)
Query Neighborhood Hits	244	Target Neighborhood Hits	55	Shared Neighborhood Hits	8
SwissProt Accessions	O60784, Q5TIJ6	Gene names	TOM1
Domain Architecture
Description	Target of Myb protein 1.

TOM1_MOUSE
θ value	θ > 10 (rank : 461)	NC score	0.058651 (rank : 338)
Query Neighborhood Hits	244	Target Neighborhood Hits	53	Shared Neighborhood Hits	7
SwissProt Accessions	O88746, Q3V4C6, Q9D120	Gene names	Tom1
Domain Architecture
Description	Target of Myb protein 1.

TRHY_HUMAN
θ value	θ > 10 (rank : 462)	NC score	0.053533 (rank : 374)
Query Neighborhood Hits	244	Target Neighborhood Hits	1385	Shared Neighborhood Hits	98
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

WDR67_HUMAN
θ value	θ > 10 (rank : 463)	NC score	0.050918 (rank : 404)
Query Neighborhood Hits	244	Target Neighborhood Hits	782	Shared Neighborhood Hits	50
SwissProt Accessions	Q96DN5, Q3MIR6, Q8TBP9	Gene names	WDR67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67.

XE7_HUMAN
θ value	θ > 10 (rank : 464)	NC score	0.050075 (rank : 414)
Query Neighborhood Hits	244	Target Neighborhood Hits	738	Shared Neighborhood Hits	68
SwissProt Accessions	Q02040, Q02832	Gene names	CXYorf3, DXYS155E, XE7
Domain Architecture	No domain graphic available
Description	B-lymphocyte antigen precursor (B-lymphocyte surface antigen) (721P) (Protein XE7).

Hits sorted by NC score

DBNL_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	244	Target Neighborhood Hits	244	Shared Neighborhood Hits	244
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
NC score	0.971926 (rank : 2)	θ value	1.08164e-170 (rank : 2)
Query Neighborhood Hits	244	Target Neighborhood Hits	306	Shared Neighborhood Hits	190
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

SRC8_HUMAN
NC score	0.713172 (rank : 3)	θ value	2.13179e-17 (rank : 6)
Query Neighborhood Hits	244	Target Neighborhood Hits	269	Shared Neighborhood Hits	153
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
NC score	0.710187 (rank : 4)	θ value	1.13037e-18 (rank : 5)
Query Neighborhood Hits	244	Target Neighborhood Hits	292	Shared Neighborhood Hits	153
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

HCLS1_MOUSE
NC score	0.699813 (rank : 5)	θ value	5.25075e-16 (rank : 8)
Query Neighborhood Hits	244	Target Neighborhood Hits	329	Shared Neighborhood Hits	153
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

HCLS1_HUMAN
NC score	0.694494 (rank : 6)	θ value	1.058e-16 (rank : 7)
Query Neighborhood Hits	244	Target Neighborhood Hits	358	Shared Neighborhood Hits	152
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

SH3G2_HUMAN
NC score	0.547668 (rank : 7)	θ value	7.59969e-07 (rank : 14)
Query Neighborhood Hits	244	Target Neighborhood Hits	324	Shared Neighborhood Hits	165
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G3_MOUSE
NC score	0.547603 (rank : 8)	θ value	1.87187e-05 (rank : 23)
Query Neighborhood Hits	244	Target Neighborhood Hits	236	Shared Neighborhood Hits	157
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

PACN2_MOUSE
NC score	0.543247 (rank : 9)	θ value	5.81887e-07 (rank : 13)
Query Neighborhood Hits	244	Target Neighborhood Hits	382	Shared Neighborhood Hits	158
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_HUMAN
NC score	0.541811 (rank : 10)	θ value	9.92553e-07 (rank : 16)
Query Neighborhood Hits	244	Target Neighborhood Hits	339	Shared Neighborhood Hits	158
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

SH3G3_HUMAN
NC score	0.536948 (rank : 11)	θ value	2.44474e-05 (rank : 26)
Query Neighborhood Hits	244	Target Neighborhood Hits	222	Shared Neighborhood Hits	151
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G2_MOUSE
NC score	0.534639 (rank : 12)	θ value	1.43324e-05 (rank : 22)
Query Neighborhood Hits	244	Target Neighborhood Hits	319	Shared Neighborhood Hits	162
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

PACN1_MOUSE
NC score	0.531109 (rank : 13)	θ value	3.77169e-06 (rank : 19)
Query Neighborhood Hits	244	Target Neighborhood Hits	283	Shared Neighborhood Hits	153
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_HUMAN
NC score	0.528264 (rank : 14)	θ value	3.77169e-06 (rank : 18)
Query Neighborhood Hits	244	Target Neighborhood Hits	320	Shared Neighborhood Hits	154
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

LASP1_HUMAN
NC score	0.521081 (rank : 15)	θ value	4.76016e-09 (rank : 9)
Query Neighborhood Hits	244	Target Neighborhood Hits	293	Shared Neighborhood Hits	135
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

STAM1_HUMAN
NC score	0.519096 (rank : 16)	θ value	1.69304e-06 (rank : 17)
Query Neighborhood Hits	244	Target Neighborhood Hits	271	Shared Neighborhood Hits	152
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
NC score	0.517679 (rank : 17)	θ value	4.45536e-07 (rank : 12)
Query Neighborhood Hits	244	Target Neighborhood Hits	273	Shared Neighborhood Hits	151
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

SH3G1_HUMAN
NC score	0.517193 (rank : 18)	θ value	5.44631e-05 (rank : 31)
Query Neighborhood Hits	244	Target Neighborhood Hits	307	Shared Neighborhood Hits	156
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3K1_HUMAN
NC score	0.516513 (rank : 19)	θ value	0.000461057 (rank : 42)
Query Neighborhood Hits	244	Target Neighborhood Hits	341	Shared Neighborhood Hits	146
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

LASP1_MOUSE
NC score	0.515481 (rank : 20)	θ value	2.36244e-08 (rank : 10)
Query Neighborhood Hits	244	Target Neighborhood Hits	297	Shared Neighborhood Hits	135
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

SH3K1_MOUSE
NC score	0.514019 (rank : 21)	θ value	0.000602161 (rank : 46)
Query Neighborhood Hits	244	Target Neighborhood Hits	332	Shared Neighborhood Hits	148
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SH3G1_MOUSE
NC score	0.511864 (rank : 22)	θ value	0.000461057 (rank : 41)
Query Neighborhood Hits	244	Target Neighborhood Hits	291	Shared Neighborhood Hits	153
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

CD2AP_MOUSE
NC score	0.511068 (rank : 23)	θ value	0.00175202 (rank : 56)
Query Neighborhood Hits	244	Target Neighborhood Hits	336	Shared Neighborhood Hits	155
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

PACN3_HUMAN
NC score	0.509016 (rank : 24)	θ value	2.44474e-05 (rank : 24)
Query Neighborhood Hits	244	Target Neighborhood Hits	385	Shared Neighborhood Hits	159
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
NC score	0.508885 (rank : 25)	θ value	2.44474e-05 (rank : 25)
Query Neighborhood Hits	244	Target Neighborhood Hits	380	Shared Neighborhood Hits	154
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

ABI2_MOUSE
NC score	0.506033 (rank : 26)	θ value	0.000786445 (rank : 48)
Query Neighborhood Hits	244	Target Neighborhood Hits	266	Shared Neighborhood Hits	140
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI2_HUMAN
NC score	0.500888 (rank : 27)	θ value	0.000786445 (rank : 47)
Query Neighborhood Hits	244	Target Neighborhood Hits	350	Shared Neighborhood Hits	141
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

DREB_MOUSE
NC score	0.499840 (rank : 28)	θ value	8.32485e-38 (rank : 4)
Query Neighborhood Hits	244	Target Neighborhood Hits	446	Shared Neighborhood Hits	58
SwissProt Accessions	Q9QXS6, Q922X1, Q9QXS5	Gene names	Dbn1, Drba
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

STAM2_MOUSE
NC score	0.499271 (rank : 29)	θ value	1.09739e-05 (rank : 21)
Query Neighborhood Hits	244	Target Neighborhood Hits	285	Shared Neighborhood Hits	150
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

DREB_HUMAN
NC score	0.497094 (rank : 30)	θ value	2.86122e-38 (rank : 3)
Query Neighborhood Hits	244	Target Neighborhood Hits	450	Shared Neighborhood Hits	56
SwissProt Accessions	Q16643	Gene names	DBN1
Domain Architecture
Description	Drebrin (Developmentally-regulated brain protein).

ABI1_MOUSE
NC score	0.496394 (rank : 31)	θ value	0.00509761 (rank : 59)
Query Neighborhood Hits	244	Target Neighborhood Hits	246	Shared Neighborhood Hits	139
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

CD2AP_HUMAN
NC score	0.494576 (rank : 32)	θ value	0.0431538 (rank : 88)
Query Neighborhood Hits	244	Target Neighborhood Hits	315	Shared Neighborhood Hits	154
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

VINEX_HUMAN
NC score	0.490830 (rank : 33)	θ value	0.0193708 (rank : 79)
Query Neighborhood Hits	244	Target Neighborhood Hits	270	Shared Neighborhood Hits	157
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
NC score	0.488477 (rank : 34)	θ value	0.00869519 (rank : 67)
Query Neighborhood Hits	244	Target Neighborhood Hits	286	Shared Neighborhood Hits	156
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

STAM2_HUMAN
NC score	0.488370 (rank : 35)	θ value	4.1701e-05 (rank : 28)
Query Neighborhood Hits	244	Target Neighborhood Hits	288	Shared Neighborhood Hits	154
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

ABI1_HUMAN
NC score	0.480601 (rank : 36)	θ value	0.00665767 (rank : 64)
Query Neighborhood Hits	244	Target Neighborhood Hits	257	Shared Neighborhood Hits	138
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

NEBL_HUMAN
NC score	0.469741 (rank : 37)	θ value	9.92553e-07 (rank : 15)
Query Neighborhood Hits	244	Target Neighborhood Hits	457	Shared Neighborhood Hits	156
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

SRBS1_MOUSE
NC score	0.466137 (rank : 38)	θ value	0.0330416 (rank : 84)
Query Neighborhood Hits	244	Target Neighborhood Hits	409	Shared Neighborhood Hits	158
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_HUMAN
NC score	0.464482 (rank : 39)	θ value	0.0736092 (rank : 94)
Query Neighborhood Hits	244	Target Neighborhood Hits	396	Shared Neighborhood Hits	161
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

GRAP2_MOUSE
NC score	0.461913 (rank : 40)	θ value	0.000786445 (rank : 50)
Query Neighborhood Hits	244	Target Neighborhood Hits	297	Shared Neighborhood Hits	153
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

NCF2_HUMAN
NC score	0.459624 (rank : 41)	θ value	2.36792 (rank : 178)
Query Neighborhood Hits	244	Target Neighborhood Hits	229	Shared Neighborhood Hits	134
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

GRAP2_HUMAN
NC score	0.458680 (rank : 42)	θ value	0.00020696 (rank : 35)
Query Neighborhood Hits	244	Target Neighborhood Hits	304	Shared Neighborhood Hits	154
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

STAC_HUMAN
NC score	0.456534 (rank : 43)	θ value	0.00390308 (rank : 58)
Query Neighborhood Hits	244	Target Neighborhood Hits	276	Shared Neighborhood Hits	142
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ABI3_MOUSE
NC score	0.447373 (rank : 44)	θ value	0.0113563 (rank : 68)
Query Neighborhood Hits	244	Target Neighborhood Hits	227	Shared Neighborhood Hits	120
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

STAC_MOUSE
NC score	0.447021 (rank : 45)	θ value	0.00298849 (rank : 57)
Query Neighborhood Hits	244	Target Neighborhood Hits	268	Shared Neighborhood Hits	139
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

GRB2_HUMAN
NC score	0.446248 (rank : 46)	θ value	0.00509761 (rank : 61)
Query Neighborhood Hits	244	Target Neighborhood Hits	310	Shared Neighborhood Hits	154
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.446038 (rank : 47)	θ value	0.00509761 (rank : 62)
Query Neighborhood Hits	244	Target Neighborhood Hits	312	Shared Neighborhood Hits	154
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

ABI3_HUMAN
NC score	0.442073 (rank : 48)	θ value	0.0252991 (rank : 80)
Query Neighborhood Hits	244	Target Neighborhood Hits	227	Shared Neighborhood Hits	120
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

PPIP1_MOUSE
NC score	0.439561 (rank : 49)	θ value	0.163984 (rank : 105)
Query Neighborhood Hits	244	Target Neighborhood Hits	377	Shared Neighborhood Hits	167
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PPIP1_HUMAN
NC score	0.435220 (rank : 50)	θ value	0.279714 (rank : 111)
Query Neighborhood Hits	244	Target Neighborhood Hits	389	Shared Neighborhood Hits	169
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

GRAP_HUMAN
NC score	0.429338 (rank : 51)	θ value	0.000602161 (rank : 43)
Query Neighborhood Hits	244	Target Neighborhood Hits	307	Shared Neighborhood Hits	151
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

NCF4_MOUSE
NC score	0.428327 (rank : 52)	θ value	0.813845 (rank : 141)
Query Neighborhood Hits	244	Target Neighborhood Hits	177	Shared Neighborhood Hits	128
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NEBU_HUMAN
NC score	0.428174 (rank : 53)	θ value	8.97725e-08 (rank : 11)
Query Neighborhood Hits	244	Target Neighborhood Hits	420	Shared Neighborhood Hits	149
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

CRKL_HUMAN
NC score	0.426468 (rank : 54)	θ value	0.000786445 (rank : 49)
Query Neighborhood Hits	244	Target Neighborhood Hits	313	Shared Neighborhood Hits	150
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
NC score	0.426369 (rank : 55)	θ value	0.000461057 (rank : 39)
Query Neighborhood Hits	244	Target Neighborhood Hits	307	Shared Neighborhood Hits	149
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

ARHG7_MOUSE
NC score	0.426369 (rank : 56)	θ value	0.00102713 (rank : 52)
Query Neighborhood Hits	244	Target Neighborhood Hits	396	Shared Neighborhood Hits	153
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

GRAP_MOUSE
NC score	0.426121 (rank : 57)	θ value	0.00509761 (rank : 60)
Query Neighborhood Hits	244	Target Neighborhood Hits	309	Shared Neighborhood Hits	155
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

ARHG7_HUMAN
NC score	0.422349 (rank : 58)	θ value	0.00102713 (rank : 51)
Query Neighborhood Hits	244	Target Neighborhood Hits	347	Shared Neighborhood Hits	148
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

STAC3_MOUSE
NC score	0.416260 (rank : 59)	θ value	0.0330416 (rank : 86)
Query Neighborhood Hits	244	Target Neighborhood Hits	232	Shared Neighborhood Hits	134
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_HUMAN
NC score	0.415612 (rank : 60)	θ value	0.0330416 (rank : 85)
Query Neighborhood Hits	244	Target Neighborhood Hits	228	Shared Neighborhood Hits	132
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

NCK2_HUMAN
NC score	0.412412 (rank : 61)	θ value	0.0148317 (rank : 73)
Query Neighborhood Hits	244	Target Neighborhood Hits	310	Shared Neighborhood Hits	151
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NCK1_HUMAN
NC score	0.412285 (rank : 62)	θ value	0.0113563 (rank : 69)
Query Neighborhood Hits	244	Target Neighborhood Hits	312	Shared Neighborhood Hits	149
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

CRK_MOUSE
NC score	0.400975 (rank : 63)	θ value	0.0193708 (rank : 76)
Query Neighborhood Hits	244	Target Neighborhood Hits	314	Shared Neighborhood Hits	147
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_HUMAN
NC score	0.398567 (rank : 64)	θ value	0.0148317 (rank : 71)
Query Neighborhood Hits	244	Target Neighborhood Hits	308	Shared Neighborhood Hits	147
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

ARHG6_MOUSE
NC score	0.398544 (rank : 65)	θ value	0.0431538 (rank : 87)
Query Neighborhood Hits	244	Target Neighborhood Hits	394	Shared Neighborhood Hits	156
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

NCF4_HUMAN
NC score	0.398469 (rank : 66)	θ value	8.99809 (rank : 237)
Query Neighborhood Hits	244	Target Neighborhood Hits	161	Shared Neighborhood Hits	116
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

DNMBP_HUMAN
NC score	0.396792 (rank : 67)	θ value	0.0330416 (rank : 83)
Query Neighborhood Hits	244	Target Neighborhood Hits	413	Shared Neighborhood Hits	160
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
NC score	0.394052 (rank : 68)	θ value	0.0148317 (rank : 72)
Query Neighborhood Hits	244	Target Neighborhood Hits	435	Shared Neighborhood Hits	159
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ARHG6_HUMAN
NC score	0.391915 (rank : 69)	θ value	0.0961366 (rank : 95)
Query Neighborhood Hits	244	Target Neighborhood Hits	376	Shared Neighborhood Hits	155
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

SNX18_MOUSE
NC score	0.374669 (rank : 70)	θ value	0.00102713 (rank : 55)
Query Neighborhood Hits	244	Target Neighborhood Hits	198	Shared Neighborhood Hits	123
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

OSTF1_HUMAN
NC score	0.371869 (rank : 71)	θ value	0.0113563 (rank : 70)
Query Neighborhood Hits	244	Target Neighborhood Hits	466	Shared Neighborhood Hits	148
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

SNX18_HUMAN
NC score	0.371739 (rank : 72)	θ value	0.00102713 (rank : 54)
Query Neighborhood Hits	244	Target Neighborhood Hits	207	Shared Neighborhood Hits	125
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

PLCG1_MOUSE
NC score	0.366081 (rank : 73)	θ value	5.44631e-05 (rank : 30)
Query Neighborhood Hits	244	Target Neighborhood Hits	314	Shared Neighborhood Hits	137
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

OSTF1_MOUSE
NC score	0.364314 (rank : 74)	θ value	0.0252991 (rank : 82)
Query Neighborhood Hits	244	Target Neighborhood Hits	467	Shared Neighborhood Hits	149
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

VAV_MOUSE
NC score	0.362111 (rank : 75)	θ value	0.00869519 (rank : 66)
Query Neighborhood Hits	244	Target Neighborhood Hits	430	Shared Neighborhood Hits	152
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV_HUMAN
NC score	0.361855 (rank : 76)	θ value	0.00509761 (rank : 63)
Query Neighborhood Hits	244	Target Neighborhood Hits	452	Shared Neighborhood Hits	155
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ITSN2_HUMAN
NC score	0.356618 (rank : 77)	θ value	0.000270298 (rank : 36)
Query Neighborhood Hits	244	Target Neighborhood Hits	1173	Shared Neighborhood Hits	213
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

ITSN1_HUMAN
NC score	0.351665 (rank : 78)	θ value	3.19293e-05 (rank : 27)
Query Neighborhood Hits	244	Target Neighborhood Hits	1757	Shared Neighborhood Hits	224
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

ITSN1_MOUSE
NC score	0.351339 (rank : 79)	θ value	8.40245e-06 (rank : 20)
Query Neighborhood Hits	244	Target Neighborhood Hits	1669	Shared Neighborhood Hits	219
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

NPHP1_MOUSE
NC score	0.350000 (rank : 80)	θ value	0.813845 (rank : 142)
Query Neighborhood Hits	244	Target Neighborhood Hits	267	Shared Neighborhood Hits	147
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

PLCG1_HUMAN
NC score	0.349925 (rank : 81)	θ value	0.000270298 (rank : 38)
Query Neighborhood Hits	244	Target Neighborhood Hits	293	Shared Neighborhood Hits	133
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

NCF1_MOUSE
NC score	0.344898 (rank : 82)	θ value	4.03905 (rank : 202)
Query Neighborhood Hits	244	Target Neighborhood Hits	198	Shared Neighborhood Hits	133
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

ITSN2_MOUSE
NC score	0.341948 (rank : 83)	θ value	0.000270298 (rank : 37)
Query Neighborhood Hits	244	Target Neighborhood Hits	1371	Shared Neighborhood Hits	211
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

PLCG2_HUMAN
NC score	0.341697 (rank : 84)	θ value	0.00665767 (rank : 65)
Query Neighborhood Hits	244	Target Neighborhood Hits	280	Shared Neighborhood Hits	137
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

NCF1_HUMAN
NC score	0.337353 (rank : 85)	θ value	θ > 10 (rank : 375)
Query Neighborhood Hits	244	Target Neighborhood Hits	198	Shared Neighborhood Hits	129
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

VAV2_MOUSE
NC score	0.329970 (rank : 86)	θ value	0.0961366 (rank : 97)
Query Neighborhood Hits	244	Target Neighborhood Hits	456	Shared Neighborhood Hits	149
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

VAV2_HUMAN
NC score	0.329326 (rank : 87)	θ value	0.0961366 (rank : 96)
Query Neighborhood Hits	244	Target Neighborhood Hits	453	Shared Neighborhood Hits	149
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

AHI1_MOUSE
NC score	0.327820 (rank : 88)	θ value	0.0252991 (rank : 81)
Query Neighborhood Hits	244	Target Neighborhood Hits	496	Shared Neighborhood Hits	151
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ARHG4_HUMAN
NC score	0.324638 (rank : 89)	θ value	7.1131e-05 (rank : 32)
Query Neighborhood Hits	244	Target Neighborhood Hits	242	Shared Neighborhood Hits	136
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

AHI1_HUMAN
NC score	0.323776 (rank : 90)	θ value	0.0736092 (rank : 93)
Query Neighborhood Hits	244	Target Neighborhood Hits	537	Shared Neighborhood Hits	151
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

CT032_HUMAN
NC score	0.322089 (rank : 91)	θ value	1.38821 (rank : 156)
Query Neighborhood Hits	244	Target Neighborhood Hits	235	Shared Neighborhood Hits	119
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

VAV3_HUMAN
NC score	0.309225 (rank : 92)	θ value	0.47712 (rank : 122)
Query Neighborhood Hits	244	Target Neighborhood Hits	398	Shared Neighborhood Hits	149
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

SHLB1_MOUSE
NC score	0.307071 (rank : 93)	θ value	0.0563607 (rank : 91)
Query Neighborhood Hits	244	Target Neighborhood Hits	101	Shared Neighborhood Hits	82
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

VAV3_MOUSE
NC score	0.306411 (rank : 94)	θ value	0.47712 (rank : 123)
Query Neighborhood Hits	244	Target Neighborhood Hits	404	Shared Neighborhood Hits	148
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

SHLB1_HUMAN
NC score	0.302139 (rank : 95)	θ value	0.0563607 (rank : 90)
Query Neighborhood Hits	244	Target Neighborhood Hits	96	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

RUSC1_HUMAN
NC score	0.300071 (rank : 96)	θ value	0.0148317 (rank : 74)
Query Neighborhood Hits	244	Target Neighborhood Hits	226	Shared Neighborhood Hits	112
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

NPHP1_HUMAN
NC score	0.298444 (rank : 97)	θ value	2.36792 (rank : 179)
Query Neighborhood Hits	244	Target Neighborhood Hits	288	Shared Neighborhood Hits	136
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

RUSC1_MOUSE
NC score	0.294138 (rank : 98)	θ value	0.0148317 (rank : 75)
Query Neighborhood Hits	244	Target Neighborhood Hits	206	Shared Neighborhood Hits	108
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

PEX13_MOUSE
NC score	0.293127 (rank : 99)	θ value	1.81305 (rank : 171)
Query Neighborhood Hits	244	Target Neighborhood Hits	126	Shared Neighborhood Hits	104
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_HUMAN
NC score	0.291048 (rank : 100)	θ value	4.03905 (rank : 203)
Query Neighborhood Hits	244	Target Neighborhood Hits	128	Shared Neighborhood Hits	102
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

SHLB2_MOUSE
NC score	0.279144 (rank : 101)	θ value	0.163984 (rank : 107)
Query Neighborhood Hits	244	Target Neighborhood Hits	88	Shared Neighborhood Hits	68
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

ARHG9_MOUSE
NC score	0.278293 (rank : 102)	θ value	0.813845 (rank : 133)
Query Neighborhood Hits	244	Target Neighborhood Hits	234	Shared Neighborhood Hits	127
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHG9_HUMAN
NC score	0.277338 (rank : 103)	θ value	0.813845 (rank : 132)
Query Neighborhood Hits	244	Target Neighborhood Hits	235	Shared Neighborhood Hits	125
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

SHLB2_HUMAN
NC score	0.277112 (rank : 104)	θ value	0.163984 (rank : 106)
Query Neighborhood Hits	244	Target Neighborhood Hits	86	Shared Neighborhood Hits	67
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

BCAR1_HUMAN
NC score	0.263689 (rank : 105)	θ value	8.99809 (rank : 232)
Query Neighborhood Hits	244	Target Neighborhood Hits	554	Shared Neighborhood Hits	139
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
NC score	0.258826 (rank : 106)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	244	Target Neighborhood Hits	438	Shared Neighborhood Hits	135
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CASL_MOUSE
NC score	0.258339 (rank : 107)	θ value	1.81305 (rank : 165)
Query Neighborhood Hits	244	Target Neighborhood Hits	225	Shared Neighborhood Hits	129
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CASL_HUMAN
NC score	0.256422 (rank : 108)	θ value	1.81305 (rank : 164)
Query Neighborhood Hits	244	Target Neighborhood Hits	259	Shared Neighborhood Hits	127
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

EFS_MOUSE
NC score	0.255450 (rank : 109)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	244	Target Neighborhood Hits	389	Shared Neighborhood Hits	129
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

COTL1_HUMAN
NC score	0.248016 (rank : 110)	θ value	5.44631e-05 (rank : 29)
Query Neighborhood Hits	244	Target Neighborhood Hits	6	Shared Neighborhood Hits	6
SwissProt Accessions	Q14019, Q86XM5	Gene names	COTL1, CLP
Domain Architecture
Description	Coactosin-like protein.

EFS_HUMAN
NC score	0.245344 (rank : 111)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	244	Target Neighborhood Hits	348	Shared Neighborhood Hits	126
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

ARHG4_MOUSE
NC score	0.243420 (rank : 112)	θ value	0.47712 (rank : 116)
Query Neighborhood Hits	244	Target Neighborhood Hits	185	Shared Neighborhood Hits	99
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

COTL1_MOUSE
NC score	0.242211 (rank : 113)	θ value	9.29e-05 (rank : 33)
Query Neighborhood Hits	244	Target Neighborhood Hits	6	Shared Neighborhood Hits	6
SwissProt Accessions	Q9CQI6	Gene names	Cotl1, Clp
Domain Architecture
Description	Coactosin-like protein.

MYO1F_HUMAN
NC score	0.238392 (rank : 114)	θ value	0.000461057 (rank : 40)
Query Neighborhood Hits	244	Target Neighborhood Hits	275	Shared Neighborhood Hits	153
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
NC score	0.236955 (rank : 115)	θ value	0.000602161 (rank : 45)
Query Neighborhood Hits	244	Target Neighborhood Hits	262	Shared Neighborhood Hits	152
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

DDEF1_MOUSE
NC score	0.230174 (rank : 116)	θ value	0.125558 (rank : 98)
Query Neighborhood Hits	244	Target Neighborhood Hits	592	Shared Neighborhood Hits	128
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

MYO1E_HUMAN
NC score	0.229407 (rank : 117)	θ value	0.00102713 (rank : 53)
Query Neighborhood Hits	244	Target Neighborhood Hits	293	Shared Neighborhood Hits	153
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

RHG26_HUMAN
NC score	0.226834 (rank : 118)	θ value	0.125558 (rank : 99)
Query Neighborhood Hits	244	Target Neighborhood Hits	281	Shared Neighborhood Hits	124
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

NOXO1_MOUSE
NC score	0.216431 (rank : 119)	θ value	θ > 10 (rank : 379)
Query Neighborhood Hits	244	Target Neighborhood Hits	114	Shared Neighborhood Hits	88
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

IASPP_HUMAN
NC score	0.216332 (rank : 120)	θ value	0.62314 (rank : 128)
Query Neighborhood Hits	244	Target Neighborhood Hits	688	Shared Neighborhood Hits	133
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ANM2_HUMAN
NC score	0.215757 (rank : 121)	θ value	3.0926 (rank : 184)
Query Neighborhood Hits	244	Target Neighborhood Hits	175	Shared Neighborhood Hits	126
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ASPP1_MOUSE
NC score	0.214458 (rank : 122)	θ value	0.813845 (rank : 134)
Query Neighborhood Hits	244	Target Neighborhood Hits	1244	Shared Neighborhood Hits	165
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_HUMAN
NC score	0.211906 (rank : 123)	θ value	0.47712 (rank : 117)
Query Neighborhood Hits	244	Target Neighborhood Hits	956	Shared Neighborhood Hits	156
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

SNX9_HUMAN
NC score	0.211011 (rank : 124)	θ value	5.27518 (rank : 218)
Query Neighborhood Hits	244	Target Neighborhood Hits	148	Shared Neighborhood Hits	88
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

SPTA1_MOUSE
NC score	0.209988 (rank : 125)	θ value	0.0193708 (rank : 78)
Query Neighborhood Hits	244	Target Neighborhood Hits	675	Shared Neighborhood Hits	165
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

RIMB2_HUMAN
NC score	0.208114 (rank : 126)	θ value	θ > 10 (rank : 404)
Query Neighborhood Hits	244	Target Neighborhood Hits	263	Shared Neighborhood Hits	106
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

DDEF2_HUMAN
NC score	0.201977 (rank : 127)	θ value	0.21417 (rank : 108)
Query Neighborhood Hits	244	Target Neighborhood Hits	599	Shared Neighborhood Hits	129
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

SPTA1_HUMAN
NC score	0.199859 (rank : 128)	θ value	0.0193708 (rank : 77)
Query Neighborhood Hits	244	Target Neighborhood Hits	748	Shared Neighborhood Hits	172
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

RIMB2_MOUSE
NC score	0.199817 (rank : 129)	θ value	θ > 10 (rank : 405)
Query Neighborhood Hits	244	Target Neighborhood Hits	246	Shared Neighborhood Hits	98
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

SPTA2_HUMAN
NC score	0.199468 (rank : 130)	θ value	0.365318 (rank : 113)
Query Neighborhood Hits	244	Target Neighborhood Hits	888	Shared Neighborhood Hits	174
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

ANM2_MOUSE
NC score	0.198457 (rank : 131)	θ value	6.88961 (rank : 220)
Query Neighborhood Hits	244	Target Neighborhood Hits	175	Shared Neighborhood Hits	125
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

IASPP_MOUSE
NC score	0.197802 (rank : 132)	θ value	0.813845 (rank : 138)
Query Neighborhood Hits	244	Target Neighborhood Hits	1024	Shared Neighborhood Hits	138
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

DDEF2_MOUSE
NC score	0.196314 (rank : 133)	θ value	3.0926 (rank : 188)
Query Neighborhood Hits	244	Target Neighborhood Hits	625	Shared Neighborhood Hits	124
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

SNX9_MOUSE
NC score	0.193876 (rank : 134)	θ value	5.27518 (rank : 219)
Query Neighborhood Hits	244	Target Neighborhood Hits	141	Shared Neighborhood Hits	83
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

RHG04_HUMAN
NC score	0.193609 (rank : 135)	θ value	θ > 10 (rank : 401)
Query Neighborhood Hits	244	Target Neighborhood Hits	307	Shared Neighborhood Hits	137
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

ES8L3_MOUSE
NC score	0.191144 (rank : 136)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	244	Target Neighborhood Hits	168	Shared Neighborhood Hits	118
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

ES8L3_HUMAN
NC score	0.184662 (rank : 137)	θ value	0.62314 (rank : 125)
Query Neighborhood Hits	244	Target Neighborhood Hits	206	Shared Neighborhood Hits	110
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

SRGP2_MOUSE
NC score	0.168795 (rank : 138)	θ value	θ > 10 (rank : 448)
Query Neighborhood Hits	244	Target Neighborhood Hits	324	Shared Neighborhood Hits	136
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SRGP2_HUMAN
NC score	0.166929 (rank : 139)	θ value	θ > 10 (rank : 447)
Query Neighborhood Hits	244	Target Neighborhood Hits	331	Shared Neighborhood Hits	133
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

NOXO1_HUMAN
NC score	0.164388 (rank : 140)	θ value	θ > 10 (rank : 378)
Query Neighborhood Hits	244	Target Neighborhood Hits	100	Shared Neighborhood Hits	77
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

SPN90_HUMAN
NC score	0.164249 (rank : 141)	θ value	θ > 10 (rank : 444)
Query Neighborhood Hits	244	Target Neighborhood Hits	157	Shared Neighborhood Hits	81
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

ES8L2_HUMAN
NC score	0.160993 (rank : 142)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	244	Target Neighborhood Hits	193	Shared Neighborhood Hits	107
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

FNBP2_HUMAN
NC score	0.159600 (rank : 143)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	244	Target Neighborhood Hits	432	Shared Neighborhood Hits	144
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

SRGP1_HUMAN
NC score	0.157993 (rank : 144)	θ value	θ > 10 (rank : 446)
Query Neighborhood Hits	244	Target Neighborhood Hits	390	Shared Neighborhood Hits	135
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

P85A_MOUSE
NC score	0.155792 (rank : 145)	θ value	1.06291 (rank : 149)
Query Neighborhood Hits	244	Target Neighborhood Hits	435	Shared Neighborhood Hits	105
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

ASPP2_HUMAN
NC score	0.154991 (rank : 146)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	244	Target Neighborhood Hits	1156	Shared Neighborhood Hits	147
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

ARHG5_HUMAN
NC score	0.152440 (rank : 147)	θ value	θ > 10 (rank : 258)
Query Neighborhood Hits	244	Target Neighborhood Hits	172	Shared Neighborhood Hits	80
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

EPS8_MOUSE
NC score	0.151886 (rank : 148)	θ value	5.27518 (rank : 209)
Query Neighborhood Hits	244	Target Neighborhood Hits	157	Shared Neighborhood Hits	108
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_HUMAN
NC score	0.151880 (rank : 149)	θ value	2.36792 (rank : 176)
Query Neighborhood Hits	244	Target Neighborhood Hits	151	Shared Neighborhood Hits	92
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

P85A_HUMAN
NC score	0.150699 (rank : 150)	θ value	1.06291 (rank : 148)
Query Neighborhood Hits	244	Target Neighborhood Hits	479	Shared Neighborhood Hits	106
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

SHAN2_MOUSE
NC score	0.150299 (rank : 151)	θ value	3.0926 (rank : 196)
Query Neighborhood Hits	244	Target Neighborhood Hits	446	Shared Neighborhood Hits	91
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

ES8L2_MOUSE
NC score	0.148229 (rank : 152)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	244	Target Neighborhood Hits	169	Shared Neighborhood Hits	107
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

DOCK1_HUMAN
NC score	0.147175 (rank : 153)	θ value	0.365318 (rank : 112)
Query Neighborhood Hits	244	Target Neighborhood Hits	191	Shared Neighborhood Hits	99
SwissProt Accessions	Q14185	Gene names	DOCK1
Domain Architecture
Description	Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180).

M3KL4_HUMAN
NC score	0.146116 (rank : 154)	θ value	0.000602161 (rank : 44)
Query Neighborhood Hits	244	Target Neighborhood Hits	1087	Shared Neighborhood Hits	156
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

SPN90_MOUSE
NC score	0.144503 (rank : 155)	θ value	θ > 10 (rank : 445)
Query Neighborhood Hits	244	Target Neighborhood Hits	157	Shared Neighborhood Hits	73
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

TCGAP_MOUSE
NC score	0.142151 (rank : 156)	θ value	θ > 10 (rank : 455)
Query Neighborhood Hits	244	Target Neighborhood Hits	409	Shared Neighborhood Hits	104
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

STS2_HUMAN
NC score	0.140084 (rank : 157)	θ value	θ > 10 (rank : 453)
Query Neighborhood Hits	244	Target Neighborhood Hits	108	Shared Neighborhood Hits	71
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

P85B_HUMAN
NC score	0.139862 (rank : 158)	θ value	6.88961 (rank : 228)
Query Neighborhood Hits	244	Target Neighborhood Hits	543	Shared Neighborhood Hits	91
SwissProt Accessions	O00459, Q9UPH9	Gene names	PIK3R2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

RIMB1_MOUSE
NC score	0.139361 (rank : 159)	θ value	θ > 10 (rank : 403)
Query Neighborhood Hits	244	Target Neighborhood Hits	1376	Shared Neighborhood Hits	173
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

CIP4_HUMAN
NC score	0.138518 (rank : 160)	θ value	4.03905 (rank : 198)
Query Neighborhood Hits	244	Target Neighborhood Hits	374	Shared Neighborhood Hits	82
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

ES8L1_HUMAN
NC score	0.138220 (rank : 161)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	244	Target Neighborhood Hits	162	Shared Neighborhood Hits	91
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

RIMB1_HUMAN
NC score	0.134182 (rank : 162)	θ value	θ > 10 (rank : 402)
Query Neighborhood Hits	244	Target Neighborhood Hits	1479	Shared Neighborhood Hits	158
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

NGEF_HUMAN
NC score	0.132470 (rank : 163)	θ value	θ > 10 (rank : 376)
Query Neighborhood Hits	244	Target Neighborhood Hits	166	Shared Neighborhood Hits	68
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
NC score	0.132214 (rank : 164)	θ value	θ > 10 (rank : 377)
Query Neighborhood Hits	244	Target Neighborhood Hits	228	Shared Neighborhood Hits	75
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

AMPH_HUMAN
NC score	0.131690 (rank : 165)	θ value	θ > 10 (rank : 248)
Query Neighborhood Hits	244	Target Neighborhood Hits	455	Shared Neighborhood Hits	87
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

ES8L1_MOUSE
NC score	0.131474 (rank : 166)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	244	Target Neighborhood Hits	143	Shared Neighborhood Hits	79
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

FYN_MOUSE
NC score	0.131062 (rank : 167)	θ value	0.813845 (rank : 136)
Query Neighborhood Hits	244	Target Neighborhood Hits	1073	Shared Neighborhood Hits	149
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

P85B_MOUSE
NC score	0.129729 (rank : 168)	θ value	θ > 10 (rank : 384)
Query Neighborhood Hits	244	Target Neighborhood Hits	519	Shared Neighborhood Hits	87
SwissProt Accessions	O08908	Gene names	Pik3r2
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase p85- subunit beta) (PtdIns-3-kinase p85-beta).

FGR_HUMAN
NC score	0.129171 (rank : 169)	θ value	0.62314 (rank : 126)
Query Neighborhood Hits	244	Target Neighborhood Hits	1067	Shared Neighborhood Hits	147
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FYN_HUMAN
NC score	0.128671 (rank : 170)	θ value	0.813845 (rank : 135)
Query Neighborhood Hits	244	Target Neighborhood Hits	1078	Shared Neighborhood Hits	149
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

SRC_HUMAN
NC score	0.127313 (rank : 171)	θ value	0.125558 (rank : 100)
Query Neighborhood Hits	244	Target Neighborhood Hits	1058	Shared Neighborhood Hits	149
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

AMPH_MOUSE
NC score	0.127074 (rank : 172)	θ value	θ > 10 (rank : 249)
Query Neighborhood Hits	244	Target Neighborhood Hits	291	Shared Neighborhood Hits	76
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

TCGAP_HUMAN
NC score	0.126606 (rank : 173)	θ value	θ > 10 (rank : 454)
Query Neighborhood Hits	244	Target Neighborhood Hits	872	Shared Neighborhood Hits	108
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

FGR_MOUSE
NC score	0.126413 (rank : 174)	θ value	0.163984 (rank : 101)
Query Neighborhood Hits	244	Target Neighborhood Hits	1069	Shared Neighborhood Hits	147
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

YES_MOUSE
NC score	0.125333 (rank : 175)	θ value	0.47712 (rank : 124)
Query Neighborhood Hits	244	Target Neighborhood Hits	1052	Shared Neighborhood Hits	145
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

SLAP2_MOUSE
NC score	0.124858 (rank : 176)	θ value	θ > 10 (rank : 438)
Query Neighborhood Hits	244	Target Neighborhood Hits	136	Shared Neighborhood Hits	52
SwissProt Accessions	Q8R4L0, Q3UU74, Q8C0K2, Q8VI42, Q9D1Z9	Gene names	Sla2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2).

M3K11_HUMAN
NC score	0.124299 (rank : 177)	θ value	0.163984 (rank : 104)
Query Neighborhood Hits	244	Target Neighborhood Hits	1136	Shared Neighborhood Hits	141
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

YES_HUMAN
NC score	0.123727 (rank : 178)	θ value	0.62314 (rank : 131)
Query Neighborhood Hits	244	Target Neighborhood Hits	1059	Shared Neighborhood Hits	145
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

SLAP2_HUMAN
NC score	0.122883 (rank : 179)	θ value	θ > 10 (rank : 437)
Query Neighborhood Hits	244	Target Neighborhood Hits	139	Shared Neighborhood Hits	56
SwissProt Accessions	Q9H6Q3, Q5TH27, Q5TH28, Q8WY18, Q96QI4, Q9H135	Gene names	SLA2, C20orf156, SLAP2
Domain Architecture
Description	Src-like-adapter 2 (Src-like adapter protein 2) (SLAP-2) (Modulator of antigen receptor signaling) (MARS).

M3K10_HUMAN
NC score	0.122420 (rank : 180)	θ value	0.000158464 (rank : 34)
Query Neighborhood Hits	244	Target Neighborhood Hits	1071	Shared Neighborhood Hits	143
SwissProt Accessions	Q02779, Q12761, Q14871	Gene names	MAP3K10, MLK2, MST
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST).

M3K9_HUMAN
NC score	0.120477 (rank : 181)	θ value	0.47712 (rank : 118)
Query Neighborhood Hits	244	Target Neighborhood Hits	1123	Shared Neighborhood Hits	149
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

STS1_MOUSE
NC score	0.117707 (rank : 182)	θ value	θ > 10 (rank : 452)
Query Neighborhood Hits	244	Target Neighborhood Hits	104	Shared Neighborhood Hits	65
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

RASA1_HUMAN
NC score	0.116280 (rank : 183)	θ value	θ > 10 (rank : 399)
Query Neighborhood Hits	244	Target Neighborhood Hits	258	Shared Neighborhood Hits	58
SwissProt Accessions	P20936	Gene names	RASA1, RASA
Domain Architecture
Description	Ras GTPase-activating protein 1 (GTPase-activating protein) (GAP) (Ras p21 protein activator) (p120GAP) (RasGAP).

ARHGG_MOUSE
NC score	0.115870 (rank : 184)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	244	Target Neighborhood Hits	152	Shared Neighborhood Hits	49
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

STS1_HUMAN
NC score	0.115098 (rank : 185)	θ value	θ > 10 (rank : 451)
Query Neighborhood Hits	244	Target Neighborhood Hits	106	Shared Neighborhood Hits	64
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

BTK_HUMAN
NC score	0.112775 (rank : 186)	θ value	1.38821 (rank : 152)
Query Neighborhood Hits	244	Target Neighborhood Hits	1026	Shared Neighborhood Hits	147
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

SLAP1_HUMAN
NC score	0.112487 (rank : 187)	θ value	θ > 10 (rank : 435)
Query Neighborhood Hits	244	Target Neighborhood Hits	113	Shared Neighborhood Hits	43
SwissProt Accessions	Q13239, Q9UMQ8	Gene names	SLA, SLAP, SLAP1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (hSLAP).

SHAN1_HUMAN
NC score	0.111633 (rank : 188)	θ value	θ > 10 (rank : 422)
Query Neighborhood Hits	244	Target Neighborhood Hits	1041	Shared Neighborhood Hits	113
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SLAP1_MOUSE
NC score	0.111601 (rank : 189)	θ value	θ > 10 (rank : 436)
Query Neighborhood Hits	244	Target Neighborhood Hits	117	Shared Neighborhood Hits	42
SwissProt Accessions	Q60898, Q8C9Q8, Q8CAT0, Q8CBE9, Q8QZX8	Gene names	Sla, Slap, Slap1
Domain Architecture
Description	SRC-like-adapter (Src-like-adapter protein 1) (mSLAP).

BIN1_MOUSE
NC score	0.111461 (rank : 190)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	244	Target Neighborhood Hits	283	Shared Neighborhood Hits	76
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

BIN1_HUMAN
NC score	0.111379 (rank : 191)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	244	Target Neighborhood Hits	335	Shared Neighborhood Hits	75
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

SRC_MOUSE
NC score	0.110180 (rank : 192)	θ value	0.62314 (rank : 130)
Query Neighborhood Hits	244	Target Neighborhood Hits	1033	Shared Neighborhood Hits	135
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

HCK_MOUSE
NC score	0.108483 (rank : 193)	θ value	8.99809 (rank : 234)
Query Neighborhood Hits	244	Target Neighborhood Hits	1029	Shared Neighborhood Hits	144
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

PKHG1_HUMAN
NC score	0.108095 (rank : 194)	θ value	θ > 10 (rank : 385)
Query Neighborhood Hits	244	Target Neighborhood Hits	174	Shared Neighborhood Hits	24
SwissProt Accessions	Q9ULL1, Q5T1F2	Gene names	PLEKHG1, KIAA1209
Domain Architecture	No domain graphic available
Description	Pleckstrin homology domain-containing family G member 1.

HCK_HUMAN
NC score	0.107855 (rank : 195)	θ value	5.27518 (rank : 210)
Query Neighborhood Hits	244	Target Neighborhood Hits	1035	Shared Neighborhood Hits	145
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

BTK_MOUSE
NC score	0.107424 (rank : 196)	θ value	1.81305 (rank : 163)
Query Neighborhood Hits	244	Target Neighborhood Hits	1017	Shared Neighborhood Hits	140
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

P55G_HUMAN
NC score	0.105439 (rank : 197)	θ value	θ > 10 (rank : 382)
Query Neighborhood Hits	244	Target Neighborhood Hits	451	Shared Neighborhood Hits	71
SwissProt Accessions	Q92569, O60482	Gene names	PIK3R3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

PREX1_HUMAN
NC score	0.104475 (rank : 198)	θ value	θ > 10 (rank : 393)
Query Neighborhood Hits	244	Target Neighborhood Hits	177	Shared Neighborhood Hits	22
SwissProt Accessions	Q8TCU6, Q5JS95, Q5JS96, Q69YL2, Q7Z2L9, Q9BQH0, Q9BX55, Q9H4Q6, Q9P2D2, Q9UGQ4	Gene names	PREX1, KIAA1415
Domain Architecture
Description	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1 protein).

FRK_HUMAN
NC score	0.102976 (rank : 199)	θ value	0.62314 (rank : 127)
Query Neighborhood Hits	244	Target Neighborhood Hits	1058	Shared Neighborhood Hits	145
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

P55G_MOUSE
NC score	0.102224 (rank : 200)	θ value	θ > 10 (rank : 383)
Query Neighborhood Hits	244	Target Neighborhood Hits	401	Shared Neighborhood Hits	67
SwissProt Accessions	Q64143	Gene names	Pik3r3
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit gamma (PI3-kinase p85-subunit gamma) (PtdIns-3-kinase p85-gamma) (p55PIK).

PPIP2_HUMAN
NC score	0.102039 (rank : 201)	θ value	θ > 10 (rank : 392)
Query Neighborhood Hits	244	Target Neighborhood Hits	254	Shared Neighborhood Hits	31
SwissProt Accessions	Q9H939	Gene names	PSTPIP2
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2.

DAPP1_MOUSE
NC score	0.101873 (rank : 202)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	244	Target Neighborhood Hits	225	Shared Neighborhood Hits	47
SwissProt Accessions	Q9QXT1, Q9R178	Gene names	Dapp1, Bam32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (mDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

ARHG3_HUMAN
NC score	0.101724 (rank : 203)	θ value	θ > 10 (rank : 256)
Query Neighborhood Hits	244	Target Neighborhood Hits	82	Shared Neighborhood Hits	22
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.101666 (rank : 204)	θ value	θ > 10 (rank : 257)
Query Neighborhood Hits	244	Target Neighborhood Hits	85	Shared Neighborhood Hits	21
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHGG_HUMAN
NC score	0.101614 (rank : 205)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	244	Target Neighborhood Hits	129	Shared Neighborhood Hits	40
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

SLY_MOUSE
NC score	0.100670 (rank : 206)	θ value	θ > 10 (rank : 440)
Query Neighborhood Hits	244	Target Neighborhood Hits	108	Shared Neighborhood Hits	54
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

TIAM1_MOUSE
NC score	0.100130 (rank : 207)	θ value	θ > 10 (rank : 459)
Query Neighborhood Hits	244	Target Neighborhood Hits	205	Shared Neighborhood Hits	25
SwissProt Accessions	Q60610	Gene names	Tiam1, Tiam-1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

DAPP1_HUMAN
NC score	0.099042 (rank : 208)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	244	Target Neighborhood Hits	227	Shared Neighborhood Hits	47
SwissProt Accessions	Q9UN19, Q8TCK5, Q9UHF2	Gene names	DAPP1, BAM32
Domain Architecture
Description	Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3- phosphoinositide (hDAPP1) (B cell adapter molecule of 32 kDa) (B lymphocyte adapter protein Bam32).

ARHG8_MOUSE
NC score	0.098763 (rank : 209)	θ value	θ > 10 (rank : 260)
Query Neighborhood Hits	244	Target Neighborhood Hits	79	Shared Neighborhood Hits	22
SwissProt Accessions	Q9Z206, Q8C4I0, Q9Z1L7	Gene names	Net1, Arhgef8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (Rho guanine nucleotide exchange factor 8).

TIAM1_HUMAN
NC score	0.098376 (rank : 210)	θ value	θ > 10 (rank : 458)
Query Neighborhood Hits	244	Target Neighborhood Hits	225	Shared Neighborhood Hits	26
SwissProt Accessions	Q13009	Gene names	TIAM1
Domain Architecture
Description	T-lymphoma invasion and metastasis-inducing protein 1 (TIAM-1 protein).

MCF2L_MOUSE
NC score	0.097255 (rank : 211)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	244	Target Neighborhood Hits	255	Shared Neighborhood Hits	45
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

TEC_HUMAN
NC score	0.096092 (rank : 212)	θ value	0.0563607 (rank : 92)
Query Neighborhood Hits	244	Target Neighborhood Hits	1006	Shared Neighborhood Hits	121
SwissProt Accessions	P42680	Gene names	TEC, PSCTK4
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

BI2L1_HUMAN
NC score	0.095926 (rank : 213)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	244	Target Neighborhood Hits	156	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UHR4, Q75L21, Q75L22, Q96CV4, Q9Y2M8	Gene names	BAIAP2L1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

LYN_HUMAN
NC score	0.094795 (rank : 214)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	244	Target Neighborhood Hits	1022	Shared Neighborhood Hits	131
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_MOUSE
NC score	0.094459 (rank : 215)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	244	Target Neighborhood Hits	1023	Shared Neighborhood Hits	130
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

PPIP2_MOUSE
NC score	0.094406 (rank : 216)	θ value	8.99809 (rank : 239)
Query Neighborhood Hits	244	Target Neighborhood Hits	308	Shared Neighborhood Hits	37
SwissProt Accessions	Q99M15, Q9Z189	Gene names	Pstpip2, Mayp
Domain Architecture
Description	Proline-serine-threonine phosphatase-interacting protein 2 (Macrophage actin-associated tyrosine-phosphorylated protein) (pp37).

CSK_MOUSE
NC score	0.093862 (rank : 217)	θ value	5.27518 (rank : 208)
Query Neighborhood Hits	244	Target Neighborhood Hits	1009	Shared Neighborhood Hits	123
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CSK_HUMAN
NC score	0.093829 (rank : 218)	θ value	5.27518 (rank : 207)
Query Neighborhood Hits	244	Target Neighborhood Hits	1009	Shared Neighborhood Hits	123
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

ARHG8_HUMAN
NC score	0.093736 (rank : 219)	θ value	θ > 10 (rank : 259)
Query Neighborhood Hits	244	Target Neighborhood Hits	85	Shared Neighborhood Hits	19
SwissProt Accessions	Q7Z628, Q12773, Q96D82, Q99903, Q9UEN6	Gene names	NET1, ARHGEF8
Domain Architecture	No domain graphic available
Description	Neuroepithelial cell-transforming gene 1 protein (p65 Net1 proto- oncogene) (Rho guanine nucleotide exchange factor 8).

TXK_MOUSE
NC score	0.093365 (rank : 220)	θ value	2.36792 (rank : 182)
Query Neighborhood Hits	244	Target Neighborhood Hits	980	Shared Neighborhood Hits	115
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

RGNEF_MOUSE
NC score	0.093068 (rank : 221)	θ value	0.62314 (rank : 129)
Query Neighborhood Hits	244	Target Neighborhood Hits	641	Shared Neighborhood Hits	59
SwissProt Accessions	P97433	Gene names	Rgnef, Rhoip2
Domain Architecture
Description	Rho-guanine nucleotide exchange factor (Rho-interacting protein 2) (RhoGEF) (RIP2).

NRAP_MOUSE
NC score	0.091850 (rank : 222)	θ value	θ > 10 (rank : 381)
Query Neighborhood Hits	244	Target Neighborhood Hits	167	Shared Neighborhood Hits	9
SwissProt Accessions	Q80XB4, O35884, Q3UTY7, Q3UU10, Q80V40	Gene names	Nrap
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

TEC_MOUSE
NC score	0.091075 (rank : 223)	θ value	0.47712 (rank : 121)
Query Neighborhood Hits	244	Target Neighborhood Hits	1006	Shared Neighborhood Hits	121
SwissProt Accessions	P24604, Q9R1M9, Q9WVN0, Q9WVN1, Q9WVN2, Q9WVN3	Gene names	Tec
Domain Architecture
Description	Tyrosine-protein kinase Tec (EC 2.7.10.2).

NRAP_HUMAN
NC score	0.090421 (rank : 224)	θ value	θ > 10 (rank : 380)
Query Neighborhood Hits	244	Target Neighborhood Hits	159	Shared Neighborhood Hits	7
SwissProt Accessions	Q86VF7, O15500, Q5VWI3, Q5VWI4, Q6MZK3, Q6N026, Q6N059, Q6NSH8, Q6PDB0, Q719H6, Q86TC5, Q86TD6, Q86TE6, Q86VF6, Q8N3R6, Q8N8F9, Q8TCH0, Q96MG4	Gene names	NRAP
Domain Architecture	No domain graphic available
Description	Nebulin-related anchoring protein (N-RAP).

BAIP2_MOUSE
NC score	0.090344 (rank : 225)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	244	Target Neighborhood Hits	185	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BAIP2_HUMAN
NC score	0.088766 (rank : 226)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	244	Target Neighborhood Hits	192	Shared Neighborhood Hits	55
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

SHE_MOUSE
NC score	0.088521 (rank : 227)	θ value	θ > 10 (rank : 434)
Query Neighborhood Hits	244	Target Neighborhood Hits	169	Shared Neighborhood Hits	49
SwissProt Accessions	Q8BSD5, Q3TZT0	Gene names	She
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

MCF2_HUMAN
NC score	0.087986 (rank : 228)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	244	Target Neighborhood Hits	166	Shared Neighborhood Hits	29
SwissProt Accessions	P10911, P14919, Q5JYJ4, Q8IUF3, Q8IUF4, Q9UJB3	Gene names	MCF2, DBL
Domain Architecture
Description	Proto-oncogene DBL (Proto-oncogene MCF-2) [Contains: MCF2-transforming protein; DBL-transforming protein].

ARHGA_MOUSE
NC score	0.087050 (rank : 229)	θ value	θ > 10 (rank : 262)
Query Neighborhood Hits	244	Target Neighborhood Hits	125	Shared Neighborhood Hits	24
SwissProt Accessions	Q8C033, Q5DU38, Q80VH8, Q8BW76, Q922S7	Gene names	Arhgef10, Kiaa0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

SH24A_HUMAN
NC score	0.086776 (rank : 230)	θ value	θ > 10 (rank : 418)
Query Neighborhood Hits	244	Target Neighborhood Hits	455	Shared Neighborhood Hits	63
SwissProt Accessions	Q9H788, Q5XKC1, Q6NXE9, Q86YM2, Q96C88, Q9H7F7	Gene names	SH2D4A, SH2A
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A (Protein SH(2)A).

BLK_HUMAN
NC score	0.085505 (rank : 231)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	244	Target Neighborhood Hits	994	Shared Neighborhood Hits	120
SwissProt Accessions	P51451, Q16291	Gene names	BLK
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

SLY_HUMAN
NC score	0.085314 (rank : 232)	θ value	θ > 10 (rank : 439)
Query Neighborhood Hits	244	Target Neighborhood Hits	81	Shared Neighborhood Hits	49
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

ITK_HUMAN
NC score	0.085141 (rank : 233)	θ value	0.163984 (rank : 102)
Query Neighborhood Hits	244	Target Neighborhood Hits	1016	Shared Neighborhood Hits	115
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

SHE_HUMAN
NC score	0.085041 (rank : 234)	θ value	θ > 10 (rank : 433)
Query Neighborhood Hits	244	Target Neighborhood Hits	164	Shared Neighborhood Hits	45
SwissProt Accessions	Q5VZ18, Q8TEQ5	Gene names	SHE
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein E.

ARHGA_HUMAN
NC score	0.084377 (rank : 235)	θ value	θ > 10 (rank : 261)
Query Neighborhood Hits	244	Target Neighborhood Hits	187	Shared Neighborhood Hits	27
SwissProt Accessions	O15013, O14665, Q68D55, Q8IWD9, Q8IY77	Gene names	ARHGEF10, KIAA0294
Domain Architecture
Description	Rho guanine nucleotide exchange factor 10.

SHB_MOUSE
NC score	0.083920 (rank : 236)	θ value	θ > 10 (rank : 424)
Query Neighborhood Hits	244	Target Neighborhood Hits	137	Shared Neighborhood Hits	44
SwissProt Accessions	Q6PD21, Q3ULM3	Gene names	Shb
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

PTK6_MOUSE
NC score	0.082705 (rank : 237)	θ value	θ > 10 (rank : 395)
Query Neighborhood Hits	244	Target Neighborhood Hits	1026	Shared Neighborhood Hits	131
SwissProt Accessions	Q64434	Gene names	Ptk6, Sik
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (SRC-related intestinal kinase).

TXK_HUMAN
NC score	0.082610 (rank : 238)	θ value	8.99809 (rank : 243)
Query Neighborhood Hits	244	Target Neighborhood Hits	971	Shared Neighborhood Hits	105
SwissProt Accessions	P42681, Q14220	Gene names	TXK
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2).

SHC3_MOUSE
NC score	0.082107 (rank : 239)	θ value	θ > 10 (rank : 430)
Query Neighborhood Hits	244	Target Neighborhood Hits	151	Shared Neighborhood Hits	45
SwissProt Accessions	Q61120	Gene names	Shc3, Nshc, ShcC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc).

BLK_MOUSE
NC score	0.081863 (rank : 240)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	244	Target Neighborhood Hits	992	Shared Neighborhood Hits	110
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

ABL1_MOUSE
NC score	0.081787 (rank : 241)	θ value	θ > 10 (rank : 246)
Query Neighborhood Hits	244	Target Neighborhood Hits	1178	Shared Neighborhood Hits	119
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

CCD91_HUMAN
NC score	0.081398 (rank : 242)	θ value	1.81305 (rank : 166)
Query Neighborhood Hits	244	Target Neighborhood Hits	868	Shared Neighborhood Hits	61
SwissProt Accessions	Q7Z6B0, Q68D43, Q6IA78, Q8NEN7, Q9NUW9	Gene names	CCDC91, GGABP
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 91 (GGA-binding partner) (p56 accessory protein).

ITK_MOUSE
NC score	0.081298 (rank : 243)	θ value	0.163984 (rank : 103)
Query Neighborhood Hits	244	Target Neighborhood Hits	985	Shared Neighborhood Hits	103
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

SHB_HUMAN
NC score	0.081285 (rank : 244)	θ value	θ > 10 (rank : 423)
Query Neighborhood Hits	244	Target Neighborhood Hits	141	Shared Neighborhood Hits	44
SwissProt Accessions	Q15464, Q504U5, Q5VUM8	Gene names	SHB
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein B.

RUSC2_HUMAN
NC score	0.081017 (rank : 245)	θ value	θ > 10 (rank : 406)
Query Neighborhood Hits	244	Target Neighborhood Hits	205	Shared Neighborhood Hits	50
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

LCK_HUMAN
NC score	0.080523 (rank : 246)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	244	Target Neighborhood Hits	987	Shared Neighborhood Hits	102
SwissProt Accessions	P06239, P07100, Q12850, Q13152, Q5TDH8, Q5TDH9, Q96DW4, Q9NYT8	Gene names	LCK
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK) (T cell- specific protein-tyrosine kinase).

ABL1_HUMAN
NC score	0.080358 (rank : 247)	θ value	θ > 10 (rank : 245)
Query Neighborhood Hits	244	Target Neighborhood Hits	1220	Shared Neighborhood Hits	119
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

PTK6_HUMAN
NC score	0.080355 (rank : 248)	θ value	θ > 10 (rank : 394)
Query Neighborhood Hits	244	Target Neighborhood Hits	1020	Shared Neighborhood Hits	134
SwissProt Accessions	Q13882	Gene names	PTK6, BRK
Domain Architecture
Description	Tyrosine-protein kinase 6 (EC 2.7.10.2) (Breast tumor kinase) (Tyrosine-protein kinase BRK).

LCK_MOUSE
NC score	0.079796 (rank : 249)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	244	Target Neighborhood Hits	981	Shared Neighborhood Hits	102
SwissProt Accessions	P06240, Q61794, Q61795, Q62320, Q91X65	Gene names	Lck, Lsk-t
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (p56-LCK) (Lymphocyte cell-specific protein-tyrosine kinase) (LSK).

BI2L1_MOUSE
NC score	0.079109 (rank : 250)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	244	Target Neighborhood Hits	197	Shared Neighborhood Hits	54
SwissProt Accessions	Q9DBJ3	Gene names	Baiap2l1
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1).

GRB14_MOUSE
NC score	0.078668 (rank : 251)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	244	Target Neighborhood Hits	149	Shared Neighborhood Hits	39
SwissProt Accessions	Q9JLM9, Q3UI77, Q8VDI2, Q9CR03	Gene names	Grb14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

APS_HUMAN
NC score	0.078495 (rank : 252)	θ value	θ > 10 (rank : 250)
Query Neighborhood Hits	244	Target Neighborhood Hits	162	Shared Neighborhood Hits	38
SwissProt Accessions	O14492	Gene names	APS
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

HAPIP_HUMAN
NC score	0.078083 (rank : 253)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	244	Target Neighborhood Hits	350	Shared Neighborhood Hits	40
SwissProt Accessions	O60229	Gene names	HAPIP, DUO
Domain Architecture
Description	Huntingtin-associated protein-interacting protein (Protein Duo).

ECT2_MOUSE
NC score	0.077928 (rank : 254)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	244	Target Neighborhood Hits	98	Shared Neighborhood Hits	21
SwissProt Accessions	Q07139	Gene names	Ect2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

SH21B_MOUSE
NC score	0.077882 (rank : 255)	θ value	θ > 10 (rank : 415)
Query Neighborhood Hits	244	Target Neighborhood Hits	101	Shared Neighborhood Hits	32
SwissProt Accessions	O35324, Q8C268	Gene names	Sh2d1b, Eat2, Sh2d1b1
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

RUSC2_MOUSE
NC score	0.077831 (rank : 256)	θ value	θ > 10 (rank : 407)
Query Neighborhood Hits	244	Target Neighborhood Hits	305	Shared Neighborhood Hits	58
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SHC1_MOUSE
NC score	0.077466 (rank : 257)	θ value	θ > 10 (rank : 426)
Query Neighborhood Hits	244	Target Neighborhood Hits	180	Shared Neighborhood Hits	46
SwissProt Accessions	P98083, Q3U2Q7, Q8BFY3, Q8K4C6, Q8K4C7	Gene names	Shc1, Shc, ShcA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

GRB14_HUMAN
NC score	0.077027 (rank : 258)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	244	Target Neighborhood Hits	137	Shared Neighborhood Hits	40
SwissProt Accessions	Q14449, Q7Z6I1	Gene names	GRB14
Domain Architecture
Description	Growth factor receptor-bound protein 14 (GRB14 adapter protein).

ABL2_HUMAN
NC score	0.076925 (rank : 259)	θ value	θ > 10 (rank : 247)
Query Neighborhood Hits	244	Target Neighborhood Hits	1045	Shared Neighborhood Hits	107
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

HSH2D_HUMAN
NC score	0.076539 (rank : 260)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	244	Target Neighborhood Hits	159	Shared Neighborhood Hits	36
SwissProt Accessions	Q96JZ2, Q6ZNG7	Gene names	HSH2D, ALX
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

SH21B_HUMAN
NC score	0.076436 (rank : 261)	θ value	θ > 10 (rank : 414)
Query Neighborhood Hits	244	Target Neighborhood Hits	101	Shared Neighborhood Hits	33
SwissProt Accessions	O14796, Q5T0L1, Q8NI18, Q969K9	Gene names	SH2D1B, EAT2
Domain Architecture
Description	SH2 domain protein 1B (EWS/FLI1-activated transcript 2) (EAT-2).

SHC3_HUMAN
NC score	0.076347 (rank : 262)	θ value	θ > 10 (rank : 429)
Query Neighborhood Hits	244	Target Neighborhood Hits	155	Shared Neighborhood Hits	41
SwissProt Accessions	Q92529, Q8TAP2, Q9UCX5	Gene names	SHC3, NSHC, SHCC
Domain Architecture
Description	SHC-transforming protein 3 (SH2 domain protein C3) (Src homology 2 domain-containing-transforming protein C3) (Neuronal Shc) (N-Shc) (Protein Rai).

ZC313_HUMAN
NC score	0.076139 (rank : 263)	θ value	0.813845 (rank : 143)
Query Neighborhood Hits	244	Target Neighborhood Hits	772	Shared Neighborhood Hits	55
SwissProt Accessions	Q5T200, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6	Gene names	ZC3H13, KIAA0853
Domain Architecture	No domain graphic available
Description	Zinc finger CCCH domain-containing protein 13.

SHC2_MOUSE
NC score	0.075989 (rank : 264)	θ value	θ > 10 (rank : 428)
Query Neighborhood Hits	244	Target Neighborhood Hits	144	Shared Neighborhood Hits	44
SwissProt Accessions	Q8BMC3	Gene names	Shc2, Sck, ShcB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck) (Protein Sli).

ECT2_HUMAN
NC score	0.075343 (rank : 265)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	244	Target Neighborhood Hits	98	Shared Neighborhood Hits	21
SwissProt Accessions	Q9H8V3, Q9NSV8, Q9NVW9	Gene names	ECT2
Domain Architecture
Description	ECT2 protein (Epithelial cell-transforming sequence 2 oncogene).

SHC1_HUMAN
NC score	0.074917 (rank : 266)	θ value	θ > 10 (rank : 425)
Query Neighborhood Hits	244	Target Neighborhood Hits	170	Shared Neighborhood Hits	44
SwissProt Accessions	P29353, O15290, Q8N4K5, Q96CL1	Gene names	SHC1, SHC, SHCA
Domain Architecture
Description	SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1).

SHC2_HUMAN
NC score	0.074276 (rank : 267)	θ value	θ > 10 (rank : 427)
Query Neighborhood Hits	244	Target Neighborhood Hits	170	Shared Neighborhood Hits	44
SwissProt Accessions	P98077, O60230, Q9NPL5, Q9UCX4	Gene names	SHC2, SCK, SHCB
Domain Architecture
Description	SHC-transforming protein 2 (SH2 domain protein C2) (Src homology 2 domain-containing-transforming protein C2) (Protein Sck).

ARHG1_HUMAN
NC score	0.074215 (rank : 268)	θ value	θ > 10 (rank : 252)
Query Neighborhood Hits	244	Target Neighborhood Hits	176	Shared Neighborhood Hits	20
SwissProt Accessions	Q92888, O00513, Q8N4J4, Q96BF4, Q96F17, Q9BSB1	Gene names	ARHGEF1
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (p115RhoGEF) (115 kDa guanine nucleotide exchange factor) (Sub1.5).

SHD_MOUSE
NC score	0.074140 (rank : 269)	θ value	θ > 10 (rank : 432)
Query Neighborhood Hits	244	Target Neighborhood Hits	137	Shared Neighborhood Hits	45
SwissProt Accessions	O88834, Q3SYI7	Gene names	Shd
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

NTBP1_MOUSE
NC score	0.073776 (rank : 270)	θ value	1.38821 (rank : 161)
Query Neighborhood Hits	244	Target Neighborhood Hits	528	Shared Neighborhood Hits	41
SwissProt Accessions	Q8BRM2, Q8CAA8	Gene names	Scyl1bp1, Ntklbp1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like-binding protein 1 (NTKL-binding protein 1) (NTKL-BP1) (mNTKL-BP1) (SCY1-like 1-binding protein 1) (SCYL1-binding protein 1) (SCYL1-BP1).

SHD_HUMAN
NC score	0.072141 (rank : 271)	θ value	θ > 10 (rank : 431)
Query Neighborhood Hits	244	Target Neighborhood Hits	204	Shared Neighborhood Hits	39
SwissProt Accessions	Q96IW2, Q96NC2	Gene names	SHD
Domain Architecture	No domain graphic available
Description	SH2 domain-containing adapter protein D.

ARHGC_HUMAN
NC score	0.071812 (rank : 272)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	244	Target Neighborhood Hits	351	Shared Neighborhood Hits	29
SwissProt Accessions	Q9NZN5, O15086	Gene names	ARHGEF12, KIAA0382, LARG
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

CDC37_HUMAN
NC score	0.071706 (rank : 273)	θ value	3.0926 (rank : 185)
Query Neighborhood Hits	244	Target Neighborhood Hits	506	Shared Neighborhood Hits	37
SwissProt Accessions	Q16543	Gene names	CDC37
Domain Architecture
Description	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37).

LBC_HUMAN
NC score	0.071626 (rank : 274)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	244	Target Neighborhood Hits	90	Shared Neighborhood Hits	22
SwissProt Accessions	Q12802	Gene names	LBC
Domain Architecture
Description	LBC oncogene (P47) (Lymphoid blast crisis oncogene).

ARHGC_MOUSE
NC score	0.071398 (rank : 275)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	244	Target Neighborhood Hits	344	Shared Neighborhood Hits	28
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

EM55_HUMAN
NC score	0.071167 (rank : 276)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	244	Target Neighborhood Hits	228	Shared Neighborhood Hits	75
SwissProt Accessions	Q00013	Gene names	MPP1, DXS552E, EMP55
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1).

GLE1_HUMAN
NC score	0.071122 (rank : 277)	θ value	8.99809 (rank : 233)
Query Neighborhood Hits	244	Target Neighborhood Hits	445	Shared Neighborhood Hits	45
SwissProt Accessions	Q53GS7, O75458, Q53GT9, Q5VVU1, Q8NCP6, Q9UFL6	Gene names	GLE1L, GLE1
Domain Architecture	No domain graphic available
Description	Nucleoporin GLE1 (GLE1-like protein) (hGLE1).

ARHGB_HUMAN
NC score	0.070276 (rank : 278)	θ value	θ > 10 (rank : 263)
Query Neighborhood Hits	244	Target Neighborhood Hits	375	Shared Neighborhood Hits	23
SwissProt Accessions	O15085	Gene names	ARHGEF11, KIAA0380
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF).

LNK_MOUSE
NC score	0.069987 (rank : 279)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	244	Target Neighborhood Hits	132	Shared Neighborhood Hits	34
SwissProt Accessions	O09039	Gene names	Lnk
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

GRB7_MOUSE
NC score	0.069534 (rank : 280)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	244	Target Neighborhood Hits	157	Shared Neighborhood Hits	43
SwissProt Accessions	Q03160	Gene names	Grb7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7).

LNK_HUMAN
NC score	0.069500 (rank : 281)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	244	Target Neighborhood Hits	151	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UQQ2, O95184	Gene names	LNK
Domain Architecture
Description	Lymphocyte-specific adapter protein Lnk (Signal transduction protein Lnk) (Lymphocyte adapter protein).

EM55_MOUSE
NC score	0.069141 (rank : 282)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	244	Target Neighborhood Hits	221	Shared Neighborhood Hits	72
SwissProt Accessions	P70290	Gene names	Mpp1
Domain Architecture
Description	55 kDa erythrocyte membrane protein (p55) (Membrane protein, palmitoylated 1) (Palmitoylated protein p55).

ARHG2_HUMAN
NC score	0.068800 (rank : 283)	θ value	θ > 10 (rank : 254)
Query Neighborhood Hits	244	Target Neighborhood Hits	142	Shared Neighborhood Hits	24
SwissProt Accessions	Q92974, O75142, Q15079	Gene names	ARHGEF2, KIAA0651, LFP40
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (GEF-H1 protein) (Proliferating cell nucleolar antigen p40).

JIP2_HUMAN
NC score	0.068278 (rank : 284)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	244	Target Neighborhood Hits	288	Shared Neighborhood Hits	50
SwissProt Accessions	Q13387, Q96G62, Q99771, Q9NZ59, Q9UKQ4	Gene names	MAPK8IP2, IB2, JIP2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

ARHG2_MOUSE
NC score	0.068098 (rank : 285)	θ value	θ > 10 (rank : 255)
Query Neighborhood Hits	244	Target Neighborhood Hits	120	Shared Neighborhood Hits	26
SwissProt Accessions	Q60875, O09115	Gene names	Arhgef2, Lbcl1, Lfc
Domain Architecture
Description	Rho/Rac guanine nucleotide exchange factor 2 (Lymphoid blast crisis- like 1) (LBC'S first cousin) (Oncogene LFC) (RHOBIN).

PLCB2_HUMAN
NC score	0.067654 (rank : 286)	θ value	θ > 10 (rank : 389)
Query Neighborhood Hits	244	Target Neighborhood Hits	608	Shared Neighborhood Hits	53
SwissProt Accessions	Q00722	Gene names	PLCB2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-2) (PLC-beta-2).

PLCB3_HUMAN
NC score	0.067504 (rank : 287)	θ value	2.36792 (rank : 180)
Query Neighborhood Hits	244	Target Neighborhood Hits	445	Shared Neighborhood Hits	45
SwissProt Accessions	Q01970	Gene names	PLCB3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

JIP2_MOUSE
NC score	0.067478 (rank : 288)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	244	Target Neighborhood Hits	144	Shared Neighborhood Hits	48
SwissProt Accessions	Q9ERE9, Q9CXI4	Gene names	Mapk8ip2, Ib2, Jip2
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 2 (JNK-interacting protein 2) (JIP-2) (JNK MAP kinase scaffold protein 2) (Islet-brain-2) (IB-2) (Mitogen-activated protein kinase 8-interacting protein 2).

LCP2_MOUSE
NC score	0.066532 (rank : 289)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	244	Target Neighborhood Hits	177	Shared Neighborhood Hits	38
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

CNTRB_MOUSE
NC score	0.066202 (rank : 290)	θ value	1.81305 (rank : 167)
Query Neighborhood Hits	244	Target Neighborhood Hits	1029	Shared Neighborhood Hits	75
SwissProt Accessions	Q8CB62, Q5NCF3	Gene names	Cntrob, Lip8
Domain Architecture	No domain graphic available
Description	Centrobin (LYST-interacting protein 8).

SH22A_MOUSE
NC score	0.065507 (rank : 291)	θ value	θ > 10 (rank : 417)
Query Neighborhood Hits	244	Target Neighborhood Hits	179	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QXK9, Q9JHP6	Gene names	Sh2d2a, Lad, Ribp
Domain Architecture
Description	SH2 domain protein 2A (Lck-associated adapter protein) (Lad) (Rlk/Itk- binding protein) (Ribp).

ARHG1_MOUSE
NC score	0.065303 (rank : 292)	θ value	θ > 10 (rank : 253)
Query Neighborhood Hits	244	Target Neighborhood Hits	266	Shared Neighborhood Hits	16
SwissProt Accessions	Q61210, O89074, Q80YE8, Q80YE9, Q91VL3	Gene names	Arhgef1, Lbcl2, Lsc
Domain Architecture
Description	Rho guanine nucleotide exchange factor 1 (Lymphoid blast crisis-like 2) (Lbc's second cousin).

FGD3_MOUSE
NC score	0.065120 (rank : 293)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	244	Target Neighborhood Hits	257	Shared Neighborhood Hits	21
SwissProt Accessions	O88842, Q8BQ72	Gene names	Fgd3
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3.

SRMS_MOUSE
NC score	0.064951 (rank : 294)	θ value	θ > 10 (rank : 450)
Query Neighborhood Hits	244	Target Neighborhood Hits	964	Shared Neighborhood Hits	92
SwissProt Accessions	Q62270, Q62360, Q923M5	Gene names	Srms, Srm
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2) (PTK70).

GNRP_MOUSE
NC score	0.064928 (rank : 295)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	244	Target Neighborhood Hits	191	Shared Neighborhood Hits	23
SwissProt Accessions	P27671	Gene names	Rasgrf1, Cdc25, Grf1
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (CDC25Mm).

AZI1_HUMAN
NC score	0.064754 (rank : 296)	θ value	2.36792 (rank : 174)
Query Neighborhood Hits	244	Target Neighborhood Hits	1000	Shared Neighborhood Hits	73
SwissProt Accessions	Q9UPN4, Q96F50	Gene names	AZI1, CEP131, KIAA1118
Domain Architecture	No domain graphic available
Description	5-azacytidine-induced protein 1 (Pre-acrosome localization protein 1) (Centrosomal protein of 131 kDa) (Cep131 protein).

FGD4_HUMAN
NC score	0.064607 (rank : 297)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	244	Target Neighborhood Hits	219	Shared Neighborhood Hits	30
SwissProt Accessions	Q96M96, Q6ULS2, Q8TCP6	Gene names	FGD4, FRABP, ZFYVE6
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein) (Zinc finger FYVE domain-containing protein 6).

SMC1A_MOUSE
NC score	0.064574 (rank : 298)	θ value	1.81305 (rank : 172)
Query Neighborhood Hits	244	Target Neighborhood Hits	1384	Shared Neighborhood Hits	86
SwissProt Accessions	Q9CU62, Q3V480, Q9CUX9, Q9D959, Q9WTU1	Gene names	Smc1l1, Sb1.8, Smc1, Smcb
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Chromosome segregation protein SmcB) (Sb1.8).

SH21A_HUMAN
NC score	0.064407 (rank : 299)	θ value	θ > 10 (rank : 412)
Query Neighborhood Hits	244	Target Neighborhood Hits	89	Shared Neighborhood Hits	31
SwissProt Accessions	O60880, O95383, O95384, O95385, O95386, Q9UNR0	Gene names	SH2D1A, DSHP, SAP
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP) (Duncan disease SH2-protein).

PLCB4_HUMAN
NC score	0.064209 (rank : 300)	θ value	θ > 10 (rank : 390)
Query Neighborhood Hits	244	Target Neighborhood Hits	658	Shared Neighborhood Hits	48
SwissProt Accessions	Q15147, Q5JYS8, Q5JYT0, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2	Gene names	PLCB4
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-4) (PLC-beta-4).

SH21A_MOUSE
NC score	0.064064 (rank : 301)	θ value	θ > 10 (rank : 413)
Query Neighborhood Hits	244	Target Neighborhood Hits	89	Shared Neighborhood Hits	30
SwissProt Accessions	O88890, Q9QWV6	Gene names	Sh2d1a, Xlp
Domain Architecture
Description	SH2 domain protein 1A (Signaling lymphocyte activation molecule- associated protein) (SLAM-associated protein) (T cell signal transduction molecule SAP).

FGD4_MOUSE
NC score	0.063560 (rank : 302)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	244	Target Neighborhood Hits	227	Shared Neighborhood Hits	27
SwissProt Accessions	Q91ZT5, Q3UEB6, Q8BW60, Q8BZI7, Q91ZT3, Q91ZT4	Gene names	Fgd4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 4 (Actin filament- binding protein frabin) (FGD1-related F-actin-binding protein).

SH2D3_MOUSE
NC score	0.063503 (rank : 303)	θ value	θ > 10 (rank : 421)
Query Neighborhood Hits	244	Target Neighborhood Hits	174	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QZS8, Q9JME1	Gene names	Sh2d3c, Chat, Shep1
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (SH2 domain-containing Eph receptor- binding protein 1) (Cas/HEF1-associated signal transducer).

GRB7_HUMAN
NC score	0.063455 (rank : 304)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	244	Target Neighborhood Hits	156	Shared Neighborhood Hits	40
SwissProt Accessions	Q14451, Q92568, Q96DF9	Gene names	GRB7
Domain Architecture
Description	Growth factor receptor-bound protein 7 (GRB7 adapter protein) (Epidermal growth factor receptor GRB-7) (B47).

PLCB3_MOUSE
NC score	0.063186 (rank : 305)	θ value	3.0926 (rank : 195)
Query Neighborhood Hits	244	Target Neighborhood Hits	344	Shared Neighborhood Hits	35
SwissProt Accessions	P51432	Gene names	Plcb3
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 3 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-3) (PLC-beta-3).

ARHGF_HUMAN
NC score	0.062737 (rank : 306)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	244	Target Neighborhood Hits	214	Shared Neighborhood Hits	24
SwissProt Accessions	O94989, Q8N449, Q9H8B4	Gene names	ARHGEF15, KIAA0915
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 15 (Vsm-RhoGEF).

SH2D3_HUMAN
NC score	0.062441 (rank : 307)	θ value	θ > 10 (rank : 420)
Query Neighborhood Hits	244	Target Neighborhood Hits	188	Shared Neighborhood Hits	38
SwissProt Accessions	Q8N5H7, Q5HYE5, Q6UY42, Q8N6X3, Q9Y2X5	Gene names	SH2D3C, NSP3
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 3C (Novel SH2-containing protein 3).

MYH11_HUMAN
NC score	0.062140 (rank : 308)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	244	Target Neighborhood Hits	1806	Shared Neighborhood Hits	99
SwissProt Accessions	P35749, O00396, O94944, P78422	Gene names	MYH11, KIAA0866
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

FGD2_HUMAN
NC score	0.061971 (rank : 309)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	244	Target Neighborhood Hits	151	Shared Neighborhood Hits	21
SwissProt Accessions	Q7Z6J4, Q5T8I1, Q6P6A8, Q6ZNL5, Q8IZ32, Q8N868, Q9H7M2	Gene names	FGD2, ZFYVE4
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2 (Zinc finger FYVE domain-containing protein 4).

SYCP1_MOUSE
NC score	0.061960 (rank : 310)	θ value	0.0431538 (rank : 89)
Query Neighborhood Hits	244	Target Neighborhood Hits	1456	Shared Neighborhood Hits	75
SwissProt Accessions	Q62209, O09205, P70192, Q62329	Gene names	Sycp1, Scp1
Domain Architecture
Description	Synaptonemal complex protein 1 (SCP-1).

SH22A_HUMAN
NC score	0.061587 (rank : 311)	θ value	θ > 10 (rank : 416)
Query Neighborhood Hits	244	Target Neighborhood Hits	144	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NP31, O43817, Q9UPA7	Gene names	SH2D2A, SCAP, TSAD, VRAP
Domain Architecture
Description	SH2 domain protein 2A (T cell-specific adapter protein) (TSAd) (VEGF receptor-associated protein) (SH2 domain-containing adapter protein).

SMC1A_HUMAN
NC score	0.061304 (rank : 312)	θ value	θ > 10 (rank : 442)
Query Neighborhood Hits	244	Target Neighborhood Hits	1346	Shared Neighborhood Hits	81
SwissProt Accessions	Q14683, O14995, Q16351	Gene names	SMC1L1, DXS423E, KIAA0178, SB1.8, SMC1
Domain Architecture
Description	Structural maintenance of chromosome 1-like 1 protein (SMC1alpha protein) (Sb1.8).

MY18A_HUMAN
NC score	0.061229 (rank : 313)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	244	Target Neighborhood Hits	1929	Shared Neighborhood Hits	100
SwissProt Accessions	Q92614, Q8IXP8	Gene names	MYO18A, KIAA0216, MYSPDZ
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

APS_MOUSE
NC score	0.061035 (rank : 314)	θ value	θ > 10 (rank : 251)
Query Neighborhood Hits	244	Target Neighborhood Hits	134	Shared Neighborhood Hits	30
SwissProt Accessions	Q9JID9, O88936	Gene names	Aps
Domain Architecture
Description	SH2 and PH domain-containing adapter protein APS (Adapter protein with pleckstrin homology and Src homology 2 domains).

MYH9_HUMAN
NC score	0.060944 (rank : 315)	θ value	1.38821 (rank : 159)
Query Neighborhood Hits	244	Target Neighborhood Hits	1762	Shared Neighborhood Hits	97
SwissProt Accessions	P35579, O60805	Gene names	MYH9
Domain Architecture
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

PTN11_MOUSE
NC score	0.060911 (rank : 316)	θ value	θ > 10 (rank : 397)
Query Neighborhood Hits	244	Target Neighborhood Hits	227	Shared Neighborhood Hits	48
SwissProt Accessions	P35235, Q3TQ84, Q64509, Q6PCL5	Gene names	Ptpn11
Domain Architecture	No domain graphic available
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2).

PTN11_HUMAN
NC score	0.060902 (rank : 317)	θ value	θ > 10 (rank : 396)
Query Neighborhood Hits	244	Target Neighborhood Hits	227	Shared Neighborhood Hits	48
SwissProt Accessions	Q06124, Q96HD7	Gene names	PTPN11, PTP2C, SHPTP2
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 2C) (PTP-2C) (PTP-1D) (SH-PTP3) (SH- PTP2) (SHP-2) (Shp2).

GRB10_MOUSE
NC score	0.060680 (rank : 318)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	244	Target Neighborhood Hits	156	Shared Neighborhood Hits	39
SwissProt Accessions	Q60760, O35352, Q7TSA4, Q8BSH4, Q8BSS5, Q91WC5	Gene names	Grb10
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein).

GOGA4_HUMAN
NC score	0.060416 (rank : 319)	θ value	1.06291 (rank : 144)
Query Neighborhood Hits	244	Target Neighborhood Hits	2034	Shared Neighborhood Hits	103
SwissProt Accessions	Q13439, Q13270, Q13654, Q14436	Gene names	GOLGA4
Domain Architecture
Description	Golgin subfamily A member 4 (Trans-Golgi p230) (256 kDa golgin) (Golgin-245) (Protein 72.1).

FGD3_HUMAN
NC score	0.060187 (rank : 320)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	244	Target Neighborhood Hits	249	Shared Neighborhood Hits	18
SwissProt Accessions	Q5JSP0, Q7Z7D9, Q8N5G1	Gene names	FGD3, ZFYVE5
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 3 (Zinc finger FYVE domain-containing protein 5).

SMC2_HUMAN
NC score	0.060038 (rank : 321)	θ value	0.47712 (rank : 120)
Query Neighborhood Hits	244	Target Neighborhood Hits	1405	Shared Neighborhood Hits	81
SwissProt Accessions	O95347, Q9P1P2	Gene names	SMC2L1, CAPE, SMC2
Domain Architecture
Description	Structural maintenance of chromosome 2-like 1 protein (Chromosome- associated protein E) (hCAP-E) (XCAP-E homolog).

MYH11_MOUSE
NC score	0.060023 (rank : 322)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	244	Target Neighborhood Hits	1777	Shared Neighborhood Hits	96
SwissProt Accessions	O08638, O08639, Q62462, Q64195	Gene names	Myh11
Domain Architecture
Description	Myosin-11 (Myosin heavy chain, smooth muscle isoform) (SMMHC).

GRB10_HUMAN
NC score	0.060010 (rank : 323)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	244	Target Neighborhood Hits	147	Shared Neighborhood Hits	37
SwissProt Accessions	Q13322, O00427, O00701, O75222, Q92606, Q92907, Q92948	Gene names	GRB10, GRBIR, KIAA0207
Domain Architecture
Description	Growth factor receptor-bound protein 10 (GRB10 adaptor protein) (Insulin receptor-binding protein GRB-IR).

MYH10_MOUSE
NC score	0.059993 (rank : 324)	θ value	1.06291 (rank : 146)
Query Neighborhood Hits	244	Target Neighborhood Hits	1612	Shared Neighborhood Hits	90
SwissProt Accessions	Q61879, Q5SV63	Gene names	Myh10
Domain Architecture	No domain graphic available
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

MYH9_MOUSE
NC score	0.059984 (rank : 325)	θ value	1.38821 (rank : 160)
Query Neighborhood Hits	244	Target Neighborhood Hits	1829	Shared Neighborhood Hits	96
SwissProt Accessions	Q8VDD5	Gene names	Myh9
Domain Architecture	No domain graphic available
Description	Myosin-9 (Myosin heavy chain, nonmuscle IIa) (Nonmuscle myosin heavy chain IIa) (NMMHC II-a) (NMMHC-IIA) (Cellular myosin heavy chain, type A) (Nonmuscle myosin heavy chain-A) (NMMHC-A).

GNRP_HUMAN
NC score	0.059548 (rank : 326)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	244	Target Neighborhood Hits	239	Shared Neighborhood Hits	24
SwissProt Accessions	Q13972, Q16027	Gene names	RASGRF1, CDC25
Domain Architecture
Description	Guanine nucleotide-releasing protein (GNRP) (Ras-specific nucleotide exchange factor CDC25) (Ras-specific guanine nucleotide-releasing factor).

TOM1_HUMAN
NC score	0.059348 (rank : 327)	θ value	θ > 10 (rank : 460)
Query Neighborhood Hits	244	Target Neighborhood Hits	55	Shared Neighborhood Hits	8
SwissProt Accessions	O60784, Q5TIJ6	Gene names	TOM1
Domain Architecture
Description	Target of Myb protein 1.

MYH10_HUMAN
NC score	0.059345 (rank : 328)	θ value	1.06291 (rank : 145)
Query Neighborhood Hits	244	Target Neighborhood Hits	1620	Shared Neighborhood Hits	90
SwissProt Accessions	P35580, Q16087	Gene names	MYH10
Domain Architecture
Description	Myosin-10 (Myosin heavy chain, nonmuscle IIb) (Nonmuscle myosin heavy chain IIb) (NMMHC II-b) (NMMHC-IIB) (Cellular myosin heavy chain, type B) (Nonmuscle myosin heavy chain-B) (NMMHC-B).

SASH1_HUMAN
NC score	0.059258 (rank : 329)	θ value	θ > 10 (rank : 410)
Query Neighborhood Hits	244	Target Neighborhood Hits	292	Shared Neighborhood Hits	53
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

CLCB_HUMAN
NC score	0.059172 (rank : 330)	θ value	1.38821 (rank : 154)
Query Neighborhood Hits	244	Target Neighborhood Hits	137	Shared Neighborhood Hits	17
SwissProt Accessions	P09497, Q6FHW1	Gene names	CLTB
Domain Architecture
Description	Clathrin light chain B (Lcb).

MY18A_MOUSE
NC score	0.059104 (rank : 331)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	244	Target Neighborhood Hits	1989	Shared Neighborhood Hits	101
SwissProt Accessions	Q9JMH9, Q811D7	Gene names	Myo18a, Myspdz
Domain Architecture
Description	Myosin-18A (Myosin XVIIIa) (Myosin containing PDZ domain) (Molecule associated with JAK3 N-terminus) (MAJN).

HSH2D_MOUSE
NC score	0.058935 (rank : 332)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	244	Target Neighborhood Hits	124	Shared Neighborhood Hits	28
SwissProt Accessions	Q6VYH9, Q52KL3	Gene names	Hsh2d, Alx
Domain Architecture	No domain graphic available
Description	Hematopoietic SH2 domain-containing protein (Hematopoietic SH2 protein) (Adaptor in lymphocytes of unknown function X).

FGD2_MOUSE
NC score	0.058923 (rank : 333)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	244	Target Neighborhood Hits	163	Shared Neighborhood Hits	21
SwissProt Accessions	Q8BY35, O88841, Q7TSE3, Q8VDH4	Gene names	Fgd2
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 2.

PININ_HUMAN
NC score	0.058874 (rank : 334)	θ value	5.27518 (rank : 215)
Query Neighborhood Hits	244	Target Neighborhood Hits	753	Shared Neighborhood Hits	52
SwissProt Accessions	Q9H307, O60899, Q53EM7, Q6P5X4, Q7KYL1, Q99738, Q9UHZ9, Q9UQR9	Gene names	PNN, DRS, MEMA
Domain Architecture	No domain graphic available
Description	Pinin (140 kDa nuclear and cell adhesion-related phosphoprotein) (Domain-rich serine protein) (DRS-protein) (DRSP) (Melanoma metastasis clone A protein) (Desmosome-associated protein) (SR-like protein) (Nuclear protein SDK3).

CDC37_MOUSE
NC score	0.058863 (rank : 335)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	244	Target Neighborhood Hits	359	Shared Neighborhood Hits	26
SwissProt Accessions	Q61081, Q3TGP0	Gene names	Cdc37
Domain Architecture
Description	Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37).

BCAR3_HUMAN
NC score	0.058806 (rank : 336)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	244	Target Neighborhood Hits	129	Shared Neighborhood Hits	34
SwissProt Accessions	O75815, Q6UW40, Q9BR50	Gene names	BCAR3, NSP2, SH2D3B
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (SH2 domain- containing protein 3B) (Novel SH2-containing protein 2).

BCAR3_MOUSE
NC score	0.058806 (rank : 337)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	244	Target Neighborhood Hits	127	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QZK2, Q3TNC9, Q3UP10	Gene names	Bcar3, And34
Domain Architecture	No domain graphic available
Description	Breast cancer anti-estrogen resistance protein 3 (p130Cas-binding protein AND-34).

TOM1_MOUSE
NC score	0.058651 (rank : 338)	θ value	θ > 10 (rank : 461)
Query Neighborhood Hits	244	Target Neighborhood Hits	53	Shared Neighborhood Hits	7
SwissProt Accessions	O88746, Q3V4C6, Q9D120	Gene names	Tom1
Domain Architecture
Description	Target of Myb protein 1.

PLCB1_HUMAN
NC score	0.058527 (rank : 339)	θ value	θ > 10 (rank : 387)
Query Neighborhood Hits	244	Target Neighborhood Hits	614	Shared Neighborhood Hits	52
SwissProt Accessions	Q9NQ66, O60325, Q5TFF7, Q5TGC9, Q8IV93, Q9BQW2, Q9H4H2, Q9H8H5, Q9NQ65, Q9NQH9, Q9NTH4, Q9UJP6, Q9UM26	Gene names	PLCB1, KIAA0581
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

JIP1_HUMAN
NC score	0.058476 (rank : 340)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	244	Target Neighborhood Hits	271	Shared Neighborhood Hits	46
SwissProt Accessions	Q9UQF2, O43407	Gene names	MAPK8IP1, IB1, JIP1
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain 1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

LCP2_HUMAN
NC score	0.058332 (rank : 341)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	244	Target Neighborhood Hits	531	Shared Neighborhood Hits	51
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

CLCB_MOUSE
NC score	0.058004 (rank : 342)	θ value	1.38821 (rank : 155)
Query Neighborhood Hits	244	Target Neighborhood Hits	119	Shared Neighborhood Hits	16
SwissProt Accessions	Q6IRU5, Q8BR04, Q8CDX9, Q9CV35	Gene names	Cltb
Domain Architecture	No domain graphic available
Description	Clathrin light chain B (Lcb).

SAMN1_HUMAN
NC score	0.057648 (rank : 343)	θ value	θ > 10 (rank : 408)
Query Neighborhood Hits	244	Target Neighborhood Hits	74	Shared Neighborhood Hits	35
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

CA065_HUMAN
NC score	0.057559 (rank : 344)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	244	Target Neighborhood Hits	469	Shared Neighborhood Hits	47
SwissProt Accessions	Q8N715, Q8N746, Q8NA93	Gene names	C1orf65
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C1orf65.

IFT81_MOUSE
NC score	0.057474 (rank : 345)	θ value	0.813845 (rank : 139)
Query Neighborhood Hits	244	Target Neighborhood Hits	959	Shared Neighborhood Hits	60
SwissProt Accessions	O35594, Q8R4W2, Q9CSA1, Q9EQM1	Gene names	Ift81, Cdv-1, Cdv1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

MPP6_HUMAN
NC score	0.057350 (rank : 346)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	244	Target Neighborhood Hits	180	Shared Neighborhood Hits	56
SwissProt Accessions	Q9NZW5, Q9H0E1	Gene names	MPP6, VAM1
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Veli-associated MAGUK 1) (VAM-1).

FUT8_HUMAN
NC score	0.057060 (rank : 347)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	244	Target Neighborhood Hits	67	Shared Neighborhood Hits	30
SwissProt Accessions	Q9BYC5, O00235, Q9BYC6, Q9P2U5, Q9P2U6	Gene names	FUT8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

BLNK_HUMAN
NC score	0.056816 (rank : 348)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	244	Target Neighborhood Hits	228	Shared Neighborhood Hits	34
SwissProt Accessions	Q8WV28, O75498, O75499	Gene names	BLNK, BASH, SLP65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65).

CCD11_HUMAN
NC score	0.056706 (rank : 349)	θ value	2.36792 (rank : 175)
Query Neighborhood Hits	244	Target Neighborhood Hits	822	Shared Neighborhood Hits	61
SwissProt Accessions	Q96M91	Gene names	CCDC11
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 11.

CJ049_HUMAN
NC score	0.056315 (rank : 350)	θ value	1.38821 (rank : 153)
Query Neighborhood Hits	244	Target Neighborhood Hits	90	Shared Neighborhood Hits	8
SwissProt Accessions	Q8WVF2	Gene names	C10orf49
Domain Architecture	No domain graphic available
Description	Protein C10orf49 precursor.

GOGA4_MOUSE
NC score	0.056302 (rank : 351)	θ value	4.03905 (rank : 200)
Query Neighborhood Hits	244	Target Neighborhood Hits	1939	Shared Neighborhood Hits	100
SwissProt Accessions	Q91VW5, O70365, Q8CGH6	Gene names	Golga4
Domain Architecture
Description	Golgin subfamily A member 4 (tGolgin-1).

JIP1_MOUSE
NC score	0.056168 (rank : 352)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	244	Target Neighborhood Hits	259	Shared Neighborhood Hits	47
SwissProt Accessions	Q9WVI9, O35145, Q925J8, Q9R1H9, Q9R1Z1, Q9WVI7, Q9WVI8	Gene names	Mapk8ip1, Ib1, Jip1, Mapk8ip, Prkm8ip
Domain Architecture
Description	C-jun-amino-terminal kinase-interacting protein 1 (JNK-interacting protein 1) (JIP-1) (JNK MAP kinase scaffold protein 1) (Islet-brain-1) (IB-1) (Mitogen-activated protein kinase 8-interacting protein 1).

HGS_HUMAN
NC score	0.056167 (rank : 353)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	244	Target Neighborhood Hits	517	Shared Neighborhood Hits	29
SwissProt Accessions	O14964, Q9NR36	Gene names	HGS, HRS
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate (Protein pp110) (Hrs).

SRMS_HUMAN
NC score	0.055849 (rank : 354)	θ value	θ > 10 (rank : 449)
Query Neighborhood Hits	244	Target Neighborhood Hits	946	Shared Neighborhood Hits	70
SwissProt Accessions	Q9H3Y6	Gene names	SRMS, C20orf148
Domain Architecture
Description	Tyrosine-protein kinase Srms (EC 2.7.10.2).

MATK_MOUSE
NC score	0.055383 (rank : 355)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	244	Target Neighborhood Hits	952	Shared Neighborhood Hits	71
SwissProt Accessions	P41242, Q6LE90	Gene names	Matk, Ctk, Ntk
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase NTK).

MYH2_HUMAN
NC score	0.055201 (rank : 356)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	244	Target Neighborhood Hits	1491	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UKX2, Q14322, Q16229	Gene names	MYH2, MYHSA2
Domain Architecture
Description	Myosin heavy chain, skeletal muscle, adult 2 (Myosin heavy chain IIa) (MyHC-IIa).

PLCB1_MOUSE
NC score	0.055175 (rank : 357)	θ value	θ > 10 (rank : 388)
Query Neighborhood Hits	244	Target Neighborhood Hits	531	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Z1B3, Q62075, Q8K5A5, Q8K5A6, Q9Z0E5, Q9Z2T5	Gene names	Plcb1, Plcb
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

PININ_MOUSE
NC score	0.055153 (rank : 358)	θ value	5.27518 (rank : 216)
Query Neighborhood Hits	244	Target Neighborhood Hits	777	Shared Neighborhood Hits	49
SwissProt Accessions	O35691, Q8CD89, Q8CGU3	Gene names	Pnn
Domain Architecture	No domain graphic available
Description	Pinin.

BLNK_MOUSE
NC score	0.055151 (rank : 359)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	244	Target Neighborhood Hits	296	Shared Neighborhood Hits	45
SwissProt Accessions	Q9QUN3, O88504	Gene names	Blnk, Bash, Ly57, Slp65
Domain Architecture	No domain graphic available
Description	B-cell linker protein (Cytoplasmic adapter protein) (B-cell adapter containing SH2 domain protein) (B-cell adapter containing Src homology 2 domain protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (Slp-65) (Lymphocyte antigen 57).

HGS_MOUSE
NC score	0.055147 (rank : 360)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	244	Target Neighborhood Hits	589	Shared Neighborhood Hits	30
SwissProt Accessions	Q99LI8, Q61691, Q8BQW3	Gene names	Hgs, Hrs
Domain Architecture	No domain graphic available
Description	Hepatocyte growth factor-regulated tyrosine kinase substrate.

GAS7_HUMAN
NC score	0.055042 (rank : 361)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	244	Target Neighborhood Hits	258	Shared Neighborhood Hits	29
SwissProt Accessions	O60861, O43144	Gene names	GAS7, KIAA0394
Domain Architecture
Description	Growth-arrest-specific protein 7 (GAS-7).

IF3A_MOUSE
NC score	0.054854 (rank : 362)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	244	Target Neighborhood Hits	871	Shared Neighborhood Hits	73
SwissProt Accessions	P23116, Q60697, Q62162	Gene names	Eif3s10, Csma, Eif3
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a) (p162 protein) (Centrosomin).

SM1L2_HUMAN
NC score	0.054827 (rank : 363)	θ value	θ > 10 (rank : 441)
Query Neighborhood Hits	244	Target Neighborhood Hits	1019	Shared Neighborhood Hits	67
SwissProt Accessions	Q8NDV3, Q5TIC3, Q9Y3G5	Gene names	SMC1L2
Domain Architecture
Description	Structural maintenance of chromosome 1-like 2 protein (SMC1beta protein).

MED12_HUMAN
NC score	0.054768 (rank : 364)	θ value	0.47712 (rank : 119)
Query Neighborhood Hits	244	Target Neighborhood Hits	262	Shared Neighborhood Hits	26
SwissProt Accessions	Q93074, O15410, O75557, Q9UHV6, Q9UND7	Gene names	MED12, ARC240, CAGH45, HOPA, KIAA0192, TNRC11, TRAP230
Domain Architecture	No domain graphic available
Description	Mediator of RNA polymerase II transcription subunit 12 (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (OPA-containing protein) (Trinucleotide repeat-containing gene 11 protein).

FUT8_MOUSE
NC score	0.054745 (rank : 365)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	244	Target Neighborhood Hits	115	Shared Neighborhood Hits	35
SwissProt Accessions	Q9WTS2, Q921U1	Gene names	Fut8
Domain Architecture
Description	Alpha-(1,6)-fucosyltransferase (EC 2.4.1.68) (Glycoprotein 6-alpha-L- fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (alpha1-6FucT) (Fucosyltransferase 8).

MYH1_MOUSE
NC score	0.054704 (rank : 366)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	244	Target Neighborhood Hits	1461	Shared Neighborhood Hits	86
SwissProt Accessions	Q5SX40	Gene names	Myh1
Domain Architecture	No domain graphic available
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1).

MATK_HUMAN
NC score	0.054699 (rank : 367)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	244	Target Neighborhood Hits	954	Shared Neighborhood Hits	66
SwissProt Accessions	P42679	Gene names	MATK, CTK, HYL
Domain Architecture
Description	Megakaryocyte-associated tyrosine-protein kinase (EC 2.7.10.2) (Tyrosine-protein kinase CTK) (Protein kinase HYL) (Hematopoietic consensus tyrosine-lacking kinase).

MYH3_HUMAN
NC score	0.054579 (rank : 368)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	244	Target Neighborhood Hits	1660	Shared Neighborhood Hits	92
SwissProt Accessions	P11055, Q15492	Gene names	MYH3
Domain Architecture
Description	Myosin heavy chain, fast skeletal muscle, embryonic (Muscle embryonic myosin heavy chain) (SMHCE).

SASH1_MOUSE
NC score	0.054556 (rank : 369)	θ value	θ > 10 (rank : 411)
Query Neighborhood Hits	244	Target Neighborhood Hits	263	Shared Neighborhood Hits	50
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

MPP6_MOUSE
NC score	0.053827 (rank : 370)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	244	Target Neighborhood Hits	187	Shared Neighborhood Hits	58
SwissProt Accessions	Q9JLB0, Q9JLB1, Q9WV37	Gene names	Mpp6, Dlgh4, Pals2
Domain Architecture
Description	MAGUK p55 subfamily member 6 (Protein associated with Lin-7 2) (Dlgh4 protein) (P55T protein).

MYH8_MOUSE
NC score	0.053823 (rank : 371)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	244	Target Neighborhood Hits	1600	Shared Neighborhood Hits	91
SwissProt Accessions	P13542, Q5SX36	Gene names	Myh8, Myhsp
Domain Architecture	No domain graphic available
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

SAMN1_MOUSE
NC score	0.053687 (rank : 372)	θ value	θ > 10 (rank : 409)
Query Neighborhood Hits	244	Target Neighborhood Hits	69	Shared Neighborhood Hits	36
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

IF3A_HUMAN
NC score	0.053614 (rank : 373)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	244	Target Neighborhood Hits	875	Shared Neighborhood Hits	72
SwissProt Accessions	Q14152, O00653	Gene names	EIF3S10, KIAA0139
Domain Architecture
Description	Eukaryotic translation initiation factor 3 subunit 10 (eIF-3 theta) (eIF3 p167) (eIF3 p180) (eIF3 p185) (eIF3a).

TRHY_HUMAN
NC score	0.053533 (rank : 374)	θ value	θ > 10 (rank : 462)
Query Neighborhood Hits	244	Target Neighborhood Hits	1385	Shared Neighborhood Hits	98
SwissProt Accessions	Q07283	Gene names	THH, THL, TRHY
Domain Architecture
Description	Trichohyalin.

FGD1_HUMAN
NC score	0.053219 (rank : 375)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	244	Target Neighborhood Hits	367	Shared Neighborhood Hits	26
SwissProt Accessions	P98174, Q8N4D9	Gene names	FGD1, ZFYVE3
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

MYO5C_HUMAN
NC score	0.052905 (rank : 376)	θ value	θ > 10 (rank : 374)
Query Neighborhood Hits	244	Target Neighborhood Hits	1206	Shared Neighborhood Hits	68
SwissProt Accessions	Q9NQX4	Gene names	MYO5C
Domain Architecture
Description	Myosin-5C (Myosin Vc).

FARP2_MOUSE
NC score	0.052823 (rank : 377)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	244	Target Neighborhood Hits	209	Shared Neighborhood Hits	24
SwissProt Accessions	Q91VS8, Q3TAP2, Q69ZZ0	Gene names	Farp2, Kiaa0793
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 2 (FERM domain including RhoGEF) (FIR).

MYH1_HUMAN
NC score	0.052786 (rank : 378)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	244	Target Neighborhood Hits	1478	Shared Neighborhood Hits	85
SwissProt Accessions	P12882, Q9Y622	Gene names	MYH1
Domain Architecture
Description	Myosin-1 (Myosin heavy chain, skeletal muscle, adult 1) (Myosin heavy chain IIx/d) (MyHC-IIx/d).

SOCS7_MOUSE
NC score	0.052635 (rank : 379)	θ value	θ > 10 (rank : 443)
Query Neighborhood Hits	244	Target Neighborhood Hits	154	Shared Neighborhood Hits	37
SwissProt Accessions	Q8VHQ2	Gene names	Socs7, Cish7, Nap4
Domain Architecture
Description	Suppressor of cytokine signaling 7 (SOCS-7).

MDC1_HUMAN
NC score	0.052617 (rank : 380)	θ value	1.81305 (rank : 169)
Query Neighborhood Hits	244	Target Neighborhood Hits	1446	Shared Neighborhood Hits	54
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

CCD46_HUMAN
NC score	0.052440 (rank : 381)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	244	Target Neighborhood Hits	1430	Shared Neighborhood Hits	88
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

MYH8_HUMAN
NC score	0.052384 (rank : 382)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	244	Target Neighborhood Hits	1610	Shared Neighborhood Hits	91
SwissProt Accessions	P13535, Q14910	Gene names	MYH8
Domain Architecture
Description	Myosin-8 (Myosin heavy chain, skeletal muscle, perinatal) (MyHC- perinatal).

IDLC_HUMAN
NC score	0.052215 (rank : 383)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	244	Target Neighborhood Hits	348	Shared Neighborhood Hits	29
SwissProt Accessions	O14645, Q5TGH0, Q7L0I5	Gene names	DNALI1
Domain Architecture	No domain graphic available
Description	Axonemal dynein light intermediate polypeptide 1 (Inner dynein arm light chain, axonemal) (hp28).

INCE_MOUSE
NC score	0.052161 (rank : 384)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	244	Target Neighborhood Hits	903	Shared Neighborhood Hits	83
SwissProt Accessions	Q9WU62, Q7TN28, Q8BGN4, Q8CGI4	Gene names	Incenp
Domain Architecture
Description	Inner centromere protein.

EP15_HUMAN
NC score	0.052106 (rank : 385)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	244	Target Neighborhood Hits	1021	Shared Neighborhood Hits	63
SwissProt Accessions	P42566	Gene names	EPS15, AF1P
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

TCRG1_HUMAN
NC score	0.052092 (rank : 386)	θ value	θ > 10 (rank : 456)
Query Neighborhood Hits	244	Target Neighborhood Hits	929	Shared Neighborhood Hits	54
SwissProt Accessions	O14776	Gene names	TCERG1, CA150, TAF2S
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150).

TCRG1_MOUSE
NC score	0.051982 (rank : 387)	θ value	θ > 10 (rank : 457)
Query Neighborhood Hits	244	Target Neighborhood Hits	947	Shared Neighborhood Hits	54
SwissProt Accessions	Q8CGF7, Q61051, Q8C490, Q8CHT8, Q9R0R5	Gene names	Tcerg1, Taf2s
Domain Architecture	No domain graphic available
Description	Transcription elongation regulator 1 (TATA box-binding protein- associated factor 2S) (Transcription factor CA150) (p144) (Formin- binding protein 28) (FBP 28).

PLCD1_MOUSE
NC score	0.051979 (rank : 388)	θ value	θ > 10 (rank : 391)
Query Neighborhood Hits	244	Target Neighborhood Hits	106	Shared Neighborhood Hits	12
SwissProt Accessions	Q8R3B1	Gene names	Plcd1, Plcd
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-delta-1) (Phospholipase C-delta-1) (PLC-III).

CCD41_MOUSE
NC score	0.051900 (rank : 389)	θ value	4.03905 (rank : 197)
Query Neighborhood Hits	244	Target Neighborhood Hits	1399	Shared Neighborhood Hits	81
SwissProt Accessions	Q9D5R3, Q3U7X7, Q3UX57, Q80VF0	Gene names	Ccdc41
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 41.

FGD1_MOUSE
NC score	0.051855 (rank : 390)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	244	Target Neighborhood Hits	387	Shared Neighborhood Hits	23
SwissProt Accessions	P52734	Gene names	Fgd1
Domain Architecture
Description	FYVE, RhoGEF and PH domain-containing protein 1 (Faciogenital dysplasia 1 protein homolog) (Zinc finger FYVE domain-containing protein 3) (Rho/Rac guanine nucleotide exchange factor FGD1) (Rho/Rac GEF).

MYO10_HUMAN
NC score	0.051815 (rank : 391)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	244	Target Neighborhood Hits	920	Shared Neighborhood Hits	71
SwissProt Accessions	Q9HD67, Q9NYM7, Q9P110, Q9P111, Q9UHF6	Gene names	MYO10
Domain Architecture
Description	Myosin-10 (Myosin X).

FGD6_MOUSE
NC score	0.051706 (rank : 392)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	244	Target Neighborhood Hits	282	Shared Neighborhood Hits	31
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

PTN6_MOUSE
NC score	0.051675 (rank : 393)	θ value	θ > 10 (rank : 398)
Query Neighborhood Hits	244	Target Neighborhood Hits	225	Shared Neighborhood Hits	48
SwissProt Accessions	P29351, O35128, Q63872, Q63873, Q63874, Q921G3, Q9QVA6, Q9QVA7, Q9QVA8, Q9R0V6	Gene names	Ptpn6, Hcp, Hcph, Ptp1C
Domain Architecture
Description	Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (70Z-SHP) (SH-PTP1) (SHP-1) (PTPTY-42).

IDLC_MOUSE
NC score	0.051568 (rank : 394)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	244	Target Neighborhood Hits	321	Shared Neighborhood Hits	27
SwissProt Accessions	Q8BVN8	Gene names	Dnali1
Domain Architecture	No domain graphic available
Description	Axonemal dynein light intermediate polypeptide 1 (Inner dynein arm light chain, axonemal).

FER_HUMAN
NC score	0.051483 (rank : 395)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	244	Target Neighborhood Hits	1278	Shared Neighborhood Hits	85
SwissProt Accessions	P16591	Gene names	FER, TYK3
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FER (EC 2.7.10.2) (p94-FER) (c- FER).

CCD21_HUMAN
NC score	0.051349 (rank : 396)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	244	Target Neighborhood Hits	1228	Shared Neighborhood Hits	78
SwissProt Accessions	Q6P2H3, Q5VY68, Q5VY70, Q9H6Q1, Q9H828, Q9UF52	Gene names	CCDC21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

SH24A_MOUSE
NC score	0.051222 (rank : 397)	θ value	θ > 10 (rank : 419)
Query Neighborhood Hits	244	Target Neighborhood Hits	326	Shared Neighborhood Hits	43
SwissProt Accessions	Q9D7V1	Gene names	Sh2d4a
Domain Architecture	No domain graphic available
Description	SH2 domain-containing protein 4A.

CI093_HUMAN
NC score	0.051221 (rank : 398)	θ value	3.0926 (rank : 186)
Query Neighborhood Hits	244	Target Neighborhood Hits	1088	Shared Neighborhood Hits	75
SwissProt Accessions	Q6TFL3, Q5SU58, Q6P1W1, Q6ZR13, Q8N1Z4, Q8N8L3, Q8TBR2	Gene names	C9orf93
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C9orf93.

MYH7_HUMAN
NC score	0.051211 (rank : 399)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	244	Target Neighborhood Hits	1559	Shared Neighborhood Hits	83
SwissProt Accessions	P12883, Q14836, Q14837, Q14904, Q16579, Q92679, Q9H1D5, Q9UMM8	Gene names	MYH7, MYHCB
Domain Architecture
Description	Myosin heavy chain, cardiac muscle beta isoform (MyHC-beta).

CCD21_MOUSE
NC score	0.051081 (rank : 400)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	244	Target Neighborhood Hits	1135	Shared Neighborhood Hits	70
SwissProt Accessions	Q8BMK0, Q8BUF1, Q8K0E6	Gene names	Ccdc21
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 21.

LRC27_HUMAN
NC score	0.051077 (rank : 401)	θ value	0.21417 (rank : 109)
Query Neighborhood Hits	244	Target Neighborhood Hits	710	Shared Neighborhood Hits	39
SwissProt Accessions	Q9C0I9, Q5SZH6, Q5SZH8, Q5SZH9, Q86XT5, Q8N7C8, Q8NA21	Gene names	LRRC27, KIAA1674
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 27.

MYH13_HUMAN
NC score	0.050984 (rank : 402)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	244	Target Neighborhood Hits	1504	Shared Neighborhood Hits	84
SwissProt Accessions	Q9UKX3, O95252	Gene names	MYH13
Domain Architecture
Description	Myosin-13 (Myosin heavy chain, skeletal muscle, extraocular) (MyHC- eo).

MYH4_MOUSE
NC score	0.050982 (rank : 403)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	244	Target Neighborhood Hits	1476	Shared Neighborhood Hits	86
SwissProt Accessions	Q5SX39	Gene names	Myh4
Domain Architecture	No domain graphic available
Description	Myosin-4 (Myosin heavy chain, skeletal muscle, fetal).

WDR67_HUMAN
NC score	0.050918 (rank : 404)	θ value	θ > 10 (rank : 463)
Query Neighborhood Hits	244	Target Neighborhood Hits	782	Shared Neighborhood Hits	50
SwissProt Accessions	Q96DN5, Q3MIR6, Q8TBP9	Gene names	WDR67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67.

RB6I2_HUMAN
NC score	0.050836 (rank : 405)	θ value	θ > 10 (rank : 400)
Query Neighborhood Hits	244	Target Neighborhood Hits	1584	Shared Neighborhood Hits	83
SwissProt Accessions	Q8IUD2, Q6NVK2, Q8IUD3, Q8IUD4, Q8IUD5, Q8NAS1, Q9NXN5, Q9UIK7, Q9UPS1	Gene names	ERC1, ELKS, KIAA1081, RAB6IP2
Domain Architecture	No domain graphic available
Description	ELKS/RAB6-interacting/CAST family member 1 (RAB6-interacting protein 2) (ERC protein 1).

EP15_MOUSE
NC score	0.050618 (rank : 406)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	244	Target Neighborhood Hits	820	Shared Neighborhood Hits	50
SwissProt Accessions	P42567	Gene names	Eps15
Domain Architecture
Description	Epidermal growth factor receptor substrate 15 (Protein Eps15) (AF-1p protein).

GOGA1_HUMAN
NC score	0.050542 (rank : 407)	θ value	0.813845 (rank : 137)
Query Neighborhood Hits	244	Target Neighborhood Hits	1222	Shared Neighborhood Hits	70
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

SDCG8_MOUSE
NC score	0.050342 (rank : 408)	θ value	5.27518 (rank : 217)
Query Neighborhood Hits	244	Target Neighborhood Hits	886	Shared Neighborhood Hits	55
SwissProt Accessions	Q80UF4	Gene names	Sdccag8, Cccap
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (mCCCAP).

INCE_HUMAN
NC score	0.050305 (rank : 409)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	244	Target Neighborhood Hits	978	Shared Neighborhood Hits	82
SwissProt Accessions	Q9NQS7, Q5Y192	Gene names	INCENP
Domain Architecture
Description	Inner centromere protein.

MYH6_MOUSE
NC score	0.050257 (rank : 410)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	244	Target Neighborhood Hits	1501	Shared Neighborhood Hits	83
SwissProt Accessions	Q02566, Q64258, Q64738	Gene names	Myh6, Myhca
Domain Architecture
Description	Myosin heavy chain, cardiac muscle alpha isoform (MyHC-alpha).

FLIP1_HUMAN
NC score	0.050256 (rank : 411)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	244	Target Neighborhood Hits	1405	Shared Neighborhood Hits	83
SwissProt Accessions	Q7Z7B0, Q5VUL6, Q86TC3, Q8N8B9, Q96SK6, Q9NVI8, Q9ULE5	Gene names	FILIP1, KIAA1275
Domain Architecture	No domain graphic available
Description	Filamin-A-interacting protein 1 (FILIP).

PKHG4_HUMAN
NC score	0.050145 (rank : 412)	θ value	θ > 10 (rank : 386)
Query Neighborhood Hits	244	Target Neighborhood Hits	200	Shared Neighborhood Hits	17
SwissProt Accessions	Q58EX7, Q4G0J8, Q4H485, Q56A69, Q9H7K4, Q9UFW0	Gene names	PLEKHG4, PRTPHN1
Domain Architecture	No domain graphic available
Description	Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1).

BCR_HUMAN
NC score	0.050079 (rank : 413)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	244	Target Neighborhood Hits	204	Shared Neighborhood Hits	25
SwissProt Accessions	P11274, P78501, Q12842	Gene names	BCR, BCR1
Domain Architecture
Description	Breakpoint cluster region protein (EC 2.7.11.1) (NY-REN-26 antigen).

XE7_HUMAN
NC score	0.050075 (rank : 414)	θ value	θ > 10 (rank : 464)
Query Neighborhood Hits	244	Target Neighborhood Hits	738	Shared Neighborhood Hits	68
SwissProt Accessions	Q02040, Q02832	Gene names	CXYorf3, DXYS155E, XE7
Domain Architecture	No domain graphic available
Description	B-lymphocyte antigen precursor (B-lymphocyte surface antigen) (721P) (Protein XE7).

DESP_HUMAN
NC score	0.050053 (rank : 415)	θ value	1.38821 (rank : 157)
Query Neighborhood Hits	244	Target Neighborhood Hits	1470	Shared Neighborhood Hits	91
SwissProt Accessions	P15924, O75993, Q14189, Q9UHN4	Gene names	DSP
Domain Architecture
Description	Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen).

MYH14_MOUSE
NC score	0.050027 (rank : 416)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	244	Target Neighborhood Hits	1225	Shared Neighborhood Hits	71
SwissProt Accessions	Q6URW6, Q80V64, Q80ZE6	Gene names	Myh14
Domain Architecture	No domain graphic available
Description	Myosin-14 (Myosin heavy chain, nonmuscle IIc) (Nonmuscle myosin heavy chain IIc) (NMHC II-C).

IFT81_HUMAN
NC score	0.046359 (rank : 417)	θ value	3.0926 (rank : 191)
Query Neighborhood Hits	244	Target Neighborhood Hits	893	Shared Neighborhood Hits	51
SwissProt Accessions	Q8WYA0, Q8NB51, Q9BSV2, Q9UNY8	Gene names	IFT81, CDV1
Domain Architecture	No domain graphic available
Description	Intraflagellar transport 81 (Carnitine deficiency-associated protein expressed in ventricle 1) (CDV-1 protein).

NEST_HUMAN
NC score	0.045512 (rank : 418)	θ value	1.81305 (rank : 170)
Query Neighborhood Hits	244	Target Neighborhood Hits	1305	Shared Neighborhood Hits	57
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

TAOK1_MOUSE
NC score	0.043121 (rank : 419)	θ value	0.365318 (rank : 115)
Query Neighborhood Hits	244	Target Neighborhood Hits	1720	Shared Neighborhood Hits	90
SwissProt Accessions	Q5F2E8, Q69ZL2, Q8JZX2, Q91VG7	Gene names	Taok1, Kiaa1361
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1).

TAOK1_HUMAN
NC score	0.043060 (rank : 420)	θ value	0.365318 (rank : 114)
Query Neighborhood Hits	244	Target Neighborhood Hits	1734	Shared Neighborhood Hits	91
SwissProt Accessions	Q7L7X3, Q96L75, Q9H2K7, Q9H7S5, Q9P2I6	Gene names	TAOK1, KIAA1361, MAP3K16
Domain Architecture	No domain graphic available
Description	Serine/threonine-protein kinase TAO1 (EC 2.7.11.1) (Thousand and one amino acid protein 1) (STE20-like kinase PSK2) (Kinase from chicken homolog B) (hKFC-B).

MD1L1_HUMAN
NC score	0.042991 (rank : 421)	θ value	8.99809 (rank : 236)
Query Neighborhood Hits	244	Target Neighborhood Hits	893	Shared Neighborhood Hits	54
SwissProt Accessions	Q9Y6D9, Q13312, Q75MI0, Q86UM4, Q9UNH0	Gene names	MAD1L1, MAD1, TXBP181
Domain Architecture	No domain graphic available
Description	Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient-like protein 1) (MAD1-like 1) (Mitotic checkpoint MAD1 protein-homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181).

NUCB1_MOUSE
NC score	0.041709 (rank : 422)	θ value	6.88961 (rank : 227)
Query Neighborhood Hits	244	Target Neighborhood Hits	414	Shared Neighborhood Hits	39
SwissProt Accessions	Q02819, Q3TU42, Q9CWA1, Q9D8J4, Q9DBL3	Gene names	Nucb1, Nuc, Nucb
Domain Architecture	No domain graphic available
Description	Nucleobindin-1 precursor (CALNUC).

MYO9B_HUMAN
NC score	0.040192 (rank : 423)	θ value	4.03905 (rank : 201)
Query Neighborhood Hits	244	Target Neighborhood Hits	641	Shared Neighborhood Hits	36
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

CLCA_MOUSE
NC score	0.040111 (rank : 424)	θ value	5.27518 (rank : 206)
Query Neighborhood Hits	244	Target Neighborhood Hits	106	Shared Neighborhood Hits	12
SwissProt Accessions	O08585	Gene names	Clta
Domain Architecture
Description	Clathrin light chain A (Lca).

HM20A_HUMAN
NC score	0.040055 (rank : 425)	θ value	3.0926 (rank : 189)
Query Neighborhood Hits	244	Target Neighborhood Hits	343	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NP66, Q53G31, Q9NSF6	Gene names	HMG20A, HMGX1
Domain Architecture	No domain graphic available
Description	High mobility group protein 20A (HMG box-containing protein 20A) (HMG domain-containing protein HMGX1).

T23O_MOUSE
NC score	0.039989 (rank : 426)	θ value	2.36792 (rank : 181)
Query Neighborhood Hits	244	Target Neighborhood Hits	21	Shared Neighborhood Hits	3
SwissProt Accessions	P48776	Gene names	Tdo2, Tdo
Domain Architecture
Description	Tryptophan 2,3-dioxygenase (EC 1.13.11.11) (TO) (Tryptophan pyrrolase) (Tryptophanase) (Tryptophan oxygenase) (Tryptamin 2,3-dioxygenase) (TRPO).

CS029_HUMAN
NC score	0.039550 (rank : 427)	θ value	4.03905 (rank : 199)
Query Neighborhood Hits	244	Target Neighborhood Hits	329	Shared Neighborhood Hits	33
SwissProt Accessions	Q8WUQ7, O75229, Q7LE08, Q9BTA6, Q9Y5A4	Gene names	C19orf29
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C19orf29 (NY-REN-24 antigen).

SNIP1_HUMAN
NC score	0.038750 (rank : 428)	θ value	1.38821 (rank : 162)
Query Neighborhood Hits	244	Target Neighborhood Hits	80	Shared Neighborhood Hits	5
SwissProt Accessions	Q8TAD8, Q96SP9, Q9H9T7	Gene names	SNIP1
Domain Architecture
Description	Smad nuclear-interacting protein 1.

HM20A_MOUSE
NC score	0.038641 (rank : 429)	θ value	3.0926 (rank : 190)
Query Neighborhood Hits	244	Target Neighborhood Hits	348	Shared Neighborhood Hits	25
SwissProt Accessions	Q9DC33, Q3LSF9, Q6NV87, Q8BSK1, Q8C3C1, Q8CAA0, Q9CYG2	Gene names	Hmg20a, Ibraf
Domain Architecture	No domain graphic available
Description	High mobility group protein 20A (HMG box-containing protein 20A) (iBRAF) (Inhibitor of BRAF35) (HMG domain protein HMGX1).

HIP1R_MOUSE
NC score	0.038609 (rank : 430)	θ value	6.88961 (rank : 223)
Query Neighborhood Hits	244	Target Neighborhood Hits	959	Shared Neighborhood Hits	57
SwissProt Accessions	Q9JKY5	Gene names	Hip1r
Domain Architecture
Description	Huntingtin-interacting protein 1-related protein (Hip1-related).

TACC3_HUMAN
NC score	0.038438 (rank : 431)	θ value	8.99809 (rank : 242)
Query Neighborhood Hits	244	Target Neighborhood Hits	779	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y6A5, Q9UMQ1	Gene names	TACC3, ERIC1
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 3 (ERIC-1).

CTGE5_MOUSE
NC score	0.038233 (rank : 432)	θ value	3.0926 (rank : 187)
Query Neighborhood Hits	244	Target Neighborhood Hits	928	Shared Neighborhood Hits	52
SwissProt Accessions	Q8R311, Q8CIE3	Gene names	Ctage5, Mea6, Mgea6
Domain Architecture	No domain graphic available
Description	Cutaneous T-cell lymphoma-associated antigen 5 homolog (cTAGE-5 protein) (Meningioma-expressed antigen 6).

NUCB1_HUMAN
NC score	0.036579 (rank : 433)	θ value	8.99809 (rank : 238)
Query Neighborhood Hits	244	Target Neighborhood Hits	359	Shared Neighborhood Hits	31
SwissProt Accessions	Q02818, Q15838, Q7Z4J7, Q9BUR1	Gene names	NUCB1, NUC
Domain Architecture	No domain graphic available
Description	Nucleobindin-1 precursor (CALNUC).

NCOR2_MOUSE
NC score	0.036134 (rank : 434)	θ value	3.0926 (rank : 193)
Query Neighborhood Hits	244	Target Neighborhood Hits	790	Shared Neighborhood Hits	51
SwissProt Accessions	Q9WU42, Q9WU43, Q9WUC1	Gene names	Ncor2, Smrt
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC).

NCOR2_HUMAN
NC score	0.035279 (rank : 435)	θ value	3.0926 (rank : 192)
Query Neighborhood Hits	244	Target Neighborhood Hits	870	Shared Neighborhood Hits	47
SwissProt Accessions	Q9Y618, O00613, O15416, Q13354, Q9Y5U0	Gene names	NCOR2, CTG26
Domain Architecture
Description	Nuclear receptor corepressor 2 (N-CoR2) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (SMRTe) (Thyroid-, retinoic-acid-receptor-associated corepressor) (T3 receptor- associating factor) (TRAC) (CTG repeat protein 26) (SMAP270).

LAD1_MOUSE
NC score	0.035038 (rank : 436)	θ value	1.38821 (rank : 158)
Query Neighborhood Hits	244	Target Neighborhood Hits	391	Shared Neighborhood Hits	26
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

TXD11_HUMAN
NC score	0.033725 (rank : 437)	θ value	1.06291 (rank : 150)
Query Neighborhood Hits	244	Target Neighborhood Hits	402	Shared Neighborhood Hits	27
SwissProt Accessions	Q6PKC3, O95887, Q6PJA6, Q8N2Q4, Q96K45, Q96K53	Gene names	TXNDC11, EFP1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 11 (EF-hand-binding protein 1).

ZN318_HUMAN
NC score	0.033500 (rank : 438)	θ value	1.81305 (rank : 173)
Query Neighborhood Hits	244	Target Neighborhood Hits	497	Shared Neighborhood Hits	30
SwissProt Accessions	Q5VUA4, O94796, Q4G0E4, Q8NEM6, Q9UNU8, Q9Y2W9	Gene names	ZNF318
Domain Architecture	No domain graphic available
Description	Zinc finger protein 318 (Endocrine regulatory protein).

UBP8_HUMAN
NC score	0.032164 (rank : 439)	θ value	0.21417 (rank : 110)
Query Neighborhood Hits	244	Target Neighborhood Hits	751	Shared Neighborhood Hits	55
SwissProt Accessions	P40818, Q7Z3U2, Q86VA0, Q8IWI7	Gene names	USP8, KIAA0055, UBPY
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.1.2.15) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8) (Deubiquitinating enzyme 8) (hUBPy).

THUM2_HUMAN
NC score	0.031121 (rank : 440)	θ value	6.88961 (rank : 231)
Query Neighborhood Hits	244	Target Neighborhood Hits	139	Shared Neighborhood Hits	17
SwissProt Accessions	Q9BTF0	Gene names	THUMPD2, C2orf8
Domain Architecture
Description	THUMP domain-containing protein 2.

SNIP1_MOUSE
NC score	0.031079 (rank : 441)	θ value	4.03905 (rank : 205)
Query Neighborhood Hits	244	Target Neighborhood Hits	113	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BIZ6, Q3V106, Q8BIZ4	Gene names	Snip1
Domain Architecture
Description	Smad nuclear-interacting protein 1.

LRC27_MOUSE
NC score	0.030309 (rank : 442)	θ value	6.88961 (rank : 226)
Query Neighborhood Hits	244	Target Neighborhood Hits	290	Shared Neighborhood Hits	9
SwissProt Accessions	Q80YS5, Q9D6Z2	Gene names	Lrrc27
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 27.

ROCK2_HUMAN
NC score	0.028934 (rank : 443)	θ value	6.88961 (rank : 229)
Query Neighborhood Hits	244	Target Neighborhood Hits	2073	Shared Neighborhood Hits	95
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

KLC4_MOUSE
NC score	0.026747 (rank : 444)	θ value	0.813845 (rank : 140)
Query Neighborhood Hits	244	Target Neighborhood Hits	336	Shared Neighborhood Hits	23
SwissProt Accessions	Q9DBS5, Q3TCC5	Gene names	Klc4, Knsl8
Domain Architecture
Description	Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8).

DHX16_HUMAN
NC score	0.026676 (rank : 445)	θ value	1.81305 (rank : 168)
Query Neighborhood Hits	244	Target Neighborhood Hits	356	Shared Neighborhood Hits	41
SwissProt Accessions	O60231, O60322, Q969X7, Q96QC1	Gene names	DHX16, DBP2, DDX16, KIAA0577
Domain Architecture
Description	Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (EC 3.6.1.-) (DEAH-box protein 16) (ATP-dependent RNA helicase #3).

LIPS_HUMAN
NC score	0.025699 (rank : 446)	θ value	6.88961 (rank : 225)
Query Neighborhood Hits	244	Target Neighborhood Hits	314	Shared Neighborhood Hits	19
SwissProt Accessions	Q05469, Q3LRT2, Q6NSL7	Gene names	LIPE
Domain Architecture
Description	Hormone-sensitive lipase (EC 3.1.1.79) (HSL).

BAG3_HUMAN
NC score	0.024811 (rank : 447)	θ value	1.38821 (rank : 151)
Query Neighborhood Hits	244	Target Neighborhood Hits	314	Shared Neighborhood Hits	15
SwissProt Accessions	O95817, Q9NT20, Q9P120	Gene names	BAG3, BIS
Domain Architecture
Description	BAG family molecular chaperone regulator 3 (BCL-2-binding athanogene- 3) (BAG-3) (Bcl-2-binding protein Bis) (Docking protein CAIR-1).

GCP6_HUMAN
NC score	0.024572 (rank : 448)	θ value	6.88961 (rank : 222)
Query Neighborhood Hits	244	Target Neighborhood Hits	295	Shared Neighborhood Hits	23
SwissProt Accessions	Q96RT7, Q5JZ80, Q6PJ40, Q86YE9, Q9BY91, Q9UGX3, Q9UGX4	Gene names	TUBGCP6, GCP6, KIAA1669
Domain Architecture
Description	Gamma-tubulin complex component 6 (GCP-6).

PRG4_HUMAN
NC score	0.023269 (rank : 449)	θ value	8.99809 (rank : 240)
Query Neighborhood Hits	244	Target Neighborhood Hits	764	Shared Neighborhood Hits	27
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

NFH_HUMAN
NC score	0.023218 (rank : 450)	θ value	5.27518 (rank : 213)
Query Neighborhood Hits	244	Target Neighborhood Hits	1242	Shared Neighborhood Hits	61
SwissProt Accessions	P12036, Q9UJS7, Q9UQ14	Gene names	NEFH, KIAA0845, NFH
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

NFH_MOUSE
NC score	0.021144 (rank : 451)	θ value	1.06291 (rank : 147)
Query Neighborhood Hits	244	Target Neighborhood Hits	2247	Shared Neighborhood Hits	74
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

CCNB3_HUMAN
NC score	0.020791 (rank : 452)	θ value	6.88961 (rank : 221)
Query Neighborhood Hits	244	Target Neighborhood Hits	368	Shared Neighborhood Hits	27
SwissProt Accessions	Q8WWL7, Q96SB5, Q96SB6, Q96SB7, Q9NT38	Gene names	CCNB3, CYCB3
Domain Architecture
Description	G2/mitotic-specific cyclin-B3.

KLC4_HUMAN
NC score	0.020772 (rank : 453)	θ value	5.27518 (rank : 212)
Query Neighborhood Hits	244	Target Neighborhood Hits	327	Shared Neighborhood Hits	19
SwissProt Accessions	Q9NSK0	Gene names	KLC4, KNSL8
Domain Architecture
Description	Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8).

SRRM1_HUMAN
NC score	0.020008 (rank : 454)	θ value	8.99809 (rank : 241)
Query Neighborhood Hits	244	Target Neighborhood Hits	690	Shared Neighborhood Hits	26
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

WDR22_HUMAN
NC score	0.016432 (rank : 455)	θ value	2.36792 (rank : 183)
Query Neighborhood Hits	244	Target Neighborhood Hits	328	Shared Neighborhood Hits	8
SwissProt Accessions	Q96JK2, O60559, Q8N3V3, Q8N3V5	Gene names	WDR22, BCRG2, KIAA1824
Domain Architecture
Description	WD repeat protein 22 (Breakpoint cluster region protein 2) (BCRP2).

KI13A_HUMAN
NC score	0.015772 (rank : 456)	θ value	2.36792 (rank : 177)
Query Neighborhood Hits	244	Target Neighborhood Hits	359	Shared Neighborhood Hits	25
SwissProt Accessions	Q9H1H9, Q9H1H8	Gene names	KIF13A, RBKIN
Domain Architecture
Description	Kinesin-like protein KIF13A (Kinesin-like protein RBKIN).

IMA5_HUMAN
NC score	0.012940 (rank : 457)	θ value	5.27518 (rank : 211)
Query Neighborhood Hits	244	Target Neighborhood Hits	68	Shared Neighborhood Hits	3
SwissProt Accessions	O15131	Gene names	KPNA5
Domain Architecture
Description	Importin alpha-6 subunit (Karyopherin alpha-5 subunit).

NOS3_MOUSE
NC score	0.007365 (rank : 458)	θ value	5.27518 (rank : 214)
Query Neighborhood Hits	244	Target Neighborhood Hits	63	Shared Neighborhood Hits	4
SwissProt Accessions	P70313, O55056	Gene names	Nos3, Ecnos
Domain Architecture
Description	Nitric-oxide synthase, endothelial (EC 1.14.13.39) (EC-NOS) (NOS type III) (NOSIII) (Endothelial NOS) (eNOS) (Constitutive NOS) (cNOS).

SMCA2_HUMAN
NC score	0.007281 (rank : 459)	θ value	4.03905 (rank : 204)
Query Neighborhood Hits	244	Target Neighborhood Hits	503	Shared Neighborhood Hits	22
SwissProt Accessions	P51531	Gene names	SMARCA2, BRM, SNF2A, SNF2L2
Domain Architecture
Description	Probable global transcription activator SNF2L2 (EC 3.6.1.-) (ATP- dependent helicase SMARCA2) (SNF2-alpha) (SWI/SNF-related matrix- associated actin-dependent regulator of chromatin subfamily A member 2) (hBRM).

K1802_HUMAN
NC score	0.005883 (rank : 460)	θ value	6.88961 (rank : 224)
Query Neighborhood Hits	244	Target Neighborhood Hits	1378	Shared Neighborhood Hits	27
SwissProt Accessions	Q96JM3, Q6P181, Q8NC88, Q9BST0	Gene names	KIAA1802, C13orf8
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

NR1D2_HUMAN
NC score	0.003930 (rank : 461)	θ value	3.0926 (rank : 194)
Query Neighborhood Hits	244	Target Neighborhood Hits	115	Shared Neighborhood Hits	3
SwissProt Accessions	Q14995, O00402, Q86XD4	Gene names	NR1D2
Domain Architecture
Description	Orphan nuclear receptor NR1D2 (Rev-erb-beta) (EAR-1R) (Orphan nuclear hormone receptor BD73).

KTNA1_HUMAN
NC score	0.001402 (rank : 462)	θ value	8.99809 (rank : 235)
Query Neighborhood Hits	244	Target Neighborhood Hits	117	Shared Neighborhood Hits	3
SwissProt Accessions	O75449, Q5TFA8, Q5TFA9, Q86VN2, Q9NU52	Gene names	KATNA1
Domain Architecture	No domain graphic available
Description	Katanin p60 ATPase-containing subunit A1 (EC 3.6.4.3) (Katanin p60 subunit A1) (p60 katanin).

SHOX_HUMAN
NC score	0.000567 (rank : 463)	θ value	6.88961 (rank : 230)
Query Neighborhood Hits	244	Target Neighborhood Hits	363	Shared Neighborhood Hits	7
SwissProt Accessions	O15266, O00412, O00413, O15267	Gene names	SHOX, PHOG
Domain Architecture
Description	Short stature homeobox protein (Short stature homeobox-containing protein) (Pseudoautosomal homeobox-containing osteogenic protein).

ZNF96_HUMAN
NC score	-0.008006 (rank : 464)	θ value	8.99809 (rank : 244)
Query Neighborhood Hits	244	Target Neighborhood Hits	869	Shared Neighborhood Hits	13
SwissProt Accessions	O43309, O43724	Gene names	ZNF96, KIAA0426, ZNF305, ZSCAN12
Domain Architecture
Description	Zinc finger protein 96 (Zinc finger protein 305) (Zinc finger and SCAN domain-containing protein 12).