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Network neighborhood for query Sequence : SHLB2_MOUSE

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SHLB2_MOUSE
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SHLB2_HUMAN
θ value	8.28183e-171 (rank : 1)	NC score	0.999275 (rank : 2)
Query Neighborhood Hits	88	Target Neighborhood Hits	86	Shared Neighborhood Hits	86
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_MOUSE
θ value	3.37019e-164 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	88	Target Neighborhood Hits	88	Shared Neighborhood Hits	88
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB1_HUMAN
θ value	2.44341e-122 (rank : 3)	NC score	0.972281 (rank : 3)
Query Neighborhood Hits	88	Target Neighborhood Hits	96	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHLB1_MOUSE
θ value	1.63895e-118 (rank : 4)	NC score	0.968506 (rank : 4)
Query Neighborhood Hits	88	Target Neighborhood Hits	101	Shared Neighborhood Hits	65
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SH3G1_HUMAN
θ value	8.36355e-22 (rank : 5)	NC score	0.648945 (rank : 5)
Query Neighborhood Hits	88	Target Neighborhood Hits	307	Shared Neighborhood Hits	72
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	5.42112e-21 (rank : 6)	NC score	0.643682 (rank : 6)
Query Neighborhood Hits	88	Target Neighborhood Hits	291	Shared Neighborhood Hits	73
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_HUMAN
θ value	1.02238e-19 (rank : 7)	NC score	0.623094 (rank : 8)
Query Neighborhood Hits	88	Target Neighborhood Hits	324	Shared Neighborhood Hits	71
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G2_MOUSE
θ value	2.5182e-18 (rank : 8)	NC score	0.624066 (rank : 7)
Query Neighborhood Hits	88	Target Neighborhood Hits	319	Shared Neighborhood Hits	71
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G3_MOUSE
θ value	5.8054e-15 (rank : 9)	NC score	0.617962 (rank : 10)
Query Neighborhood Hits	88	Target Neighborhood Hits	236	Shared Neighborhood Hits	71
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SH3G3_HUMAN
θ value	2.20605e-14 (rank : 10)	NC score	0.622612 (rank : 9)
Query Neighborhood Hits	88	Target Neighborhood Hits	222	Shared Neighborhood Hits	70
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

VAV2_MOUSE
θ value	0.000121331 (rank : 11)	NC score	0.210805 (rank : 46)
Query Neighborhood Hits	88	Target Neighborhood Hits	456	Shared Neighborhood Hits	69
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

PPIP1_HUMAN
θ value	0.000158464 (rank : 12)	NC score	0.283898 (rank : 17)
Query Neighborhood Hits	88	Target Neighborhood Hits	389	Shared Neighborhood Hits	73
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

STAM1_HUMAN
θ value	0.000461057 (rank : 13)	NC score	0.298208 (rank : 12)
Query Neighborhood Hits	88	Target Neighborhood Hits	271	Shared Neighborhood Hits	73
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	0.000461057 (rank : 14)	NC score	0.297400 (rank : 13)
Query Neighborhood Hits	88	Target Neighborhood Hits	273	Shared Neighborhood Hits	73
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

RUSC1_HUMAN
θ value	0.000786445 (rank : 15)	NC score	0.253809 (rank : 28)
Query Neighborhood Hits	88	Target Neighborhood Hits	226	Shared Neighborhood Hits	58
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

ITSN1_HUMAN
θ value	0.00134147 (rank : 16)	NC score	0.166988 (rank : 68)
Query Neighborhood Hits	88	Target Neighborhood Hits	1757	Shared Neighborhood Hits	82
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

VAV2_HUMAN
θ value	0.00134147 (rank : 17)	NC score	0.206344 (rank : 48)
Query Neighborhood Hits	88	Target Neighborhood Hits	453	Shared Neighborhood Hits	69
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

3BP1_HUMAN
θ value	0.00175202 (rank : 18)	NC score	0.105175 (rank : 121)
Query Neighborhood Hits	88	Target Neighborhood Hits	376	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

GRAP2_MOUSE
θ value	0.00228821 (rank : 19)	NC score	0.237609 (rank : 32)
Query Neighborhood Hits	88	Target Neighborhood Hits	297	Shared Neighborhood Hits	73
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

PPIP1_MOUSE
θ value	0.00228821 (rank : 20)	NC score	0.283176 (rank : 18)
Query Neighborhood Hits	88	Target Neighborhood Hits	377	Shared Neighborhood Hits	75
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

GRAP2_HUMAN
θ value	0.00298849 (rank : 21)	NC score	0.234415 (rank : 34)
Query Neighborhood Hits	88	Target Neighborhood Hits	304	Shared Neighborhood Hits	72
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

LASP1_HUMAN
θ value	0.00298849 (rank : 22)	NC score	0.275012 (rank : 22)
Query Neighborhood Hits	88	Target Neighborhood Hits	293	Shared Neighborhood Hits	65
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
θ value	0.00298849 (rank : 23)	NC score	0.270692 (rank : 23)
Query Neighborhood Hits	88	Target Neighborhood Hits	297	Shared Neighborhood Hits	65
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LAMC1_HUMAN
θ value	0.00509761 (rank : 24)	NC score	0.031698 (rank : 181)
Query Neighborhood Hits	88	Target Neighborhood Hits	922	Shared Neighborhood Hits	12
SwissProt Accessions	P11047	Gene names	LAMC1, LAMB2
Domain Architecture
Description	Laminin gamma-1 chain precursor (Laminin B2 chain).

SPTA1_MOUSE
θ value	0.00509761 (rank : 25)	NC score	0.152157 (rank : 89)
Query Neighborhood Hits	88	Target Neighborhood Hits	675	Shared Neighborhood Hits	74
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SRBS1_HUMAN
θ value	0.00509761 (rank : 26)	NC score	0.312094 (rank : 11)
Query Neighborhood Hits	88	Target Neighborhood Hits	396	Shared Neighborhood Hits	70
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SPTA2_HUMAN
θ value	0.00665767 (rank : 27)	NC score	0.126464 (rank : 103)
Query Neighborhood Hits	88	Target Neighborhood Hits	888	Shared Neighborhood Hits	73
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

ITSN1_MOUSE
θ value	0.00869519 (rank : 28)	NC score	0.165527 (rank : 70)
Query Neighborhood Hits	88	Target Neighborhood Hits	1669	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

RUSC1_MOUSE
θ value	0.00869519 (rank : 29)	NC score	0.244464 (rank : 30)
Query Neighborhood Hits	88	Target Neighborhood Hits	206	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

STAM2_MOUSE
θ value	0.0113563 (rank : 30)	NC score	0.275317 (rank : 21)
Query Neighborhood Hits	88	Target Neighborhood Hits	285	Shared Neighborhood Hits	73
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

SRBS1_MOUSE
θ value	0.0148317 (rank : 31)	NC score	0.296849 (rank : 14)
Query Neighborhood Hits	88	Target Neighborhood Hits	409	Shared Neighborhood Hits	72
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

RHG26_HUMAN
θ value	0.0193708 (rank : 32)	NC score	0.148334 (rank : 93)
Query Neighborhood Hits	88	Target Neighborhood Hits	281	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

ES8L2_MOUSE
θ value	0.0252991 (rank : 33)	NC score	0.160010 (rank : 75)
Query Neighborhood Hits	88	Target Neighborhood Hits	169	Shared Neighborhood Hits	52
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

SNX9_MOUSE
θ value	0.0252991 (rank : 34)	NC score	0.212289 (rank : 45)
Query Neighborhood Hits	88	Target Neighborhood Hits	141	Shared Neighborhood Hits	46
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

AMPH_HUMAN
θ value	0.0431538 (rank : 35)	NC score	0.125333 (rank : 105)
Query Neighborhood Hits	88	Target Neighborhood Hits	455	Shared Neighborhood Hits	41
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

ES8L2_HUMAN
θ value	0.0431538 (rank : 36)	NC score	0.144668 (rank : 95)
Query Neighborhood Hits	88	Target Neighborhood Hits	193	Shared Neighborhood Hits	55
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

CRKL_MOUSE
θ value	0.125558 (rank : 37)	NC score	0.174301 (rank : 59)
Query Neighborhood Hits	88	Target Neighborhood Hits	307	Shared Neighborhood Hits	66
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

SNX9_HUMAN
θ value	0.125558 (rank : 38)	NC score	0.209506 (rank : 47)
Query Neighborhood Hits	88	Target Neighborhood Hits	148	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

STAM2_HUMAN
θ value	0.125558 (rank : 39)	NC score	0.257779 (rank : 27)
Query Neighborhood Hits	88	Target Neighborhood Hits	288	Shared Neighborhood Hits	72
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

DBNL_HUMAN
θ value	0.163984 (rank : 40)	NC score	0.279144 (rank : 19)
Query Neighborhood Hits	88	Target Neighborhood Hits	244	Shared Neighborhood Hits	68
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	0.163984 (rank : 41)	NC score	0.276308 (rank : 20)
Query Neighborhood Hits	88	Target Neighborhood Hits	306	Shared Neighborhood Hits	68
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

GRAP_MOUSE
θ value	0.21417 (rank : 42)	NC score	0.187078 (rank : 54)
Query Neighborhood Hits	88	Target Neighborhood Hits	309	Shared Neighborhood Hits	68
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

ITSN2_MOUSE
θ value	0.21417 (rank : 43)	NC score	0.150118 (rank : 91)
Query Neighborhood Hits	88	Target Neighborhood Hits	1371	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

SRC8_HUMAN
θ value	0.21417 (rank : 44)	NC score	0.269031 (rank : 24)
Query Neighborhood Hits	88	Target Neighborhood Hits	269	Shared Neighborhood Hits	70
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	0.21417 (rank : 45)	NC score	0.264747 (rank : 25)
Query Neighborhood Hits	88	Target Neighborhood Hits	292	Shared Neighborhood Hits	72
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

VAV_HUMAN
θ value	0.279714 (rank : 46)	NC score	0.184821 (rank : 56)
Query Neighborhood Hits	88	Target Neighborhood Hits	452	Shared Neighborhood Hits	67
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

VAV_MOUSE
θ value	0.279714 (rank : 47)	NC score	0.188193 (rank : 51)
Query Neighborhood Hits	88	Target Neighborhood Hits	430	Shared Neighborhood Hits	67
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ORC3_HUMAN
θ value	0.365318 (rank : 48)	NC score	0.053908 (rank : 170)
Query Neighborhood Hits	88	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UBD5, Q13565, Q6IUY7, Q9UG44, Q9UNT6	Gene names	ORC3L, LATHEO
Domain Architecture
Description	Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo).

VAV3_MOUSE
θ value	0.365318 (rank : 49)	NC score	0.165063 (rank : 73)
Query Neighborhood Hits	88	Target Neighborhood Hits	404	Shared Neighborhood Hits	67
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

NEBL_HUMAN
θ value	0.47712 (rank : 50)	NC score	0.216327 (rank : 43)
Query Neighborhood Hits	88	Target Neighborhood Hits	457	Shared Neighborhood Hits	64
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

SEGN_MOUSE
θ value	0.47712 (rank : 51)	NC score	0.053715 (rank : 171)
Query Neighborhood Hits	88	Target Neighborhood Hits	101	Shared Neighborhood Hits	8
SwissProt Accessions	Q91WD9	Gene names	Scgn
Domain Architecture
Description	Secretagogin.

SPTA1_HUMAN
θ value	0.47712 (rank : 52)	NC score	0.128257 (rank : 102)
Query Neighborhood Hits	88	Target Neighborhood Hits	748	Shared Neighborhood Hits	74
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

VAV3_HUMAN
θ value	0.47712 (rank : 53)	NC score	0.168013 (rank : 65)
Query Neighborhood Hits	88	Target Neighborhood Hits	398	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

VINEX_MOUSE
θ value	0.47712 (rank : 54)	NC score	0.292927 (rank : 15)
Query Neighborhood Hits	88	Target Neighborhood Hits	286	Shared Neighborhood Hits	73
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

DNMBP_MOUSE
θ value	0.62314 (rank : 55)	NC score	0.219188 (rank : 40)
Query Neighborhood Hits	88	Target Neighborhood Hits	435	Shared Neighborhood Hits	76
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ES8L3_HUMAN
θ value	0.62314 (rank : 56)	NC score	0.144171 (rank : 97)
Query Neighborhood Hits	88	Target Neighborhood Hits	206	Shared Neighborhood Hits	56
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

VINEX_HUMAN
θ value	0.62314 (rank : 57)	NC score	0.286575 (rank : 16)
Query Neighborhood Hits	88	Target Neighborhood Hits	270	Shared Neighborhood Hits	71
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

HCLS1_MOUSE
θ value	0.813845 (rank : 58)	NC score	0.262272 (rank : 26)
Query Neighborhood Hits	88	Target Neighborhood Hits	329	Shared Neighborhood Hits	71
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

RIMB2_MOUSE
θ value	0.813845 (rank : 59)	NC score	0.169284 (rank : 64)
Query Neighborhood Hits	88	Target Neighborhood Hits	246	Shared Neighborhood Hits	49
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

3BP1_MOUSE
θ value	1.38821 (rank : 60)	NC score	0.047455 (rank : 179)
Query Neighborhood Hits	88	Target Neighborhood Hits	238	Shared Neighborhood Hits	8
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

DNMBP_HUMAN
θ value	1.38821 (rank : 61)	NC score	0.216890 (rank : 42)
Query Neighborhood Hits	88	Target Neighborhood Hits	413	Shared Neighborhood Hits	76
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

ES8L3_MOUSE
θ value	1.38821 (rank : 62)	NC score	0.154154 (rank : 85)
Query Neighborhood Hits	88	Target Neighborhood Hits	168	Shared Neighborhood Hits	61
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

NFL_HUMAN
θ value	1.38821 (rank : 63)	NC score	0.012512 (rank : 189)
Query Neighborhood Hits	88	Target Neighborhood Hits	666	Shared Neighborhood Hits	13
SwissProt Accessions	P07196, Q16154, Q8IU72	Gene names	NEFL, NF68, NFL
Domain Architecture
Description	Neurofilament triplet L protein (68 kDa neurofilament protein) (Neurofilament light polypeptide) (NF-L).

CE005_HUMAN
θ value	1.81305 (rank : 64)	NC score	0.028546 (rank : 182)
Query Neighborhood Hits	88	Target Neighborhood Hits	213	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

GOGB1_HUMAN
θ value	1.81305 (rank : 65)	NC score	0.023038 (rank : 185)
Query Neighborhood Hits	88	Target Neighborhood Hits	2297	Shared Neighborhood Hits	30
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

ITSN2_HUMAN
θ value	1.81305 (rank : 66)	NC score	0.158708 (rank : 77)
Query Neighborhood Hits	88	Target Neighborhood Hits	1173	Shared Neighborhood Hits	75
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

LAMC1_MOUSE
θ value	1.81305 (rank : 67)	NC score	0.023806 (rank : 184)
Query Neighborhood Hits	88	Target Neighborhood Hits	856	Shared Neighborhood Hits	13
SwissProt Accessions	P02468	Gene names	Lamc1, Lamb-2, Lamc-1
Domain Architecture
Description	Laminin gamma-1 chain precursor (Laminin B2 chain).

AMPH_MOUSE
θ value	2.36792 (rank : 68)	NC score	0.097435 (rank : 125)
Query Neighborhood Hits	88	Target Neighborhood Hits	291	Shared Neighborhood Hits	37
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

M3KL4_HUMAN
θ value	2.36792 (rank : 69)	NC score	0.055615 (rank : 166)
Query Neighborhood Hits	88	Target Neighborhood Hits	1087	Shared Neighborhood Hits	74
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

NFL_MOUSE
θ value	2.36792 (rank : 70)	NC score	0.011509 (rank : 190)
Query Neighborhood Hits	88	Target Neighborhood Hits	695	Shared Neighborhood Hits	13
SwissProt Accessions	P08551, Q8K0Z0	Gene names	Nefl, Nf68, Nfl
Domain Architecture
Description	Neurofilament triplet L protein (68 kDa neurofilament protein) (Neurofilament light polypeptide) (NF-L).

AHI1_MOUSE
θ value	3.0926 (rank : 71)	NC score	0.136315 (rank : 100)
Query Neighborhood Hits	88	Target Neighborhood Hits	496	Shared Neighborhood Hits	69
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

ITK_MOUSE
θ value	3.0926 (rank : 72)	NC score	0.016359 (rank : 188)
Query Neighborhood Hits	88	Target Neighborhood Hits	985	Shared Neighborhood Hits	44
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

SNX18_MOUSE
θ value	3.0926 (rank : 73)	NC score	0.225824 (rank : 37)
Query Neighborhood Hits	88	Target Neighborhood Hits	198	Shared Neighborhood Hits	63
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

ITK_HUMAN
θ value	4.03905 (rank : 74)	NC score	0.018663 (rank : 186)
Query Neighborhood Hits	88	Target Neighborhood Hits	1016	Shared Neighborhood Hits	48
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

NCF1_HUMAN
θ value	4.03905 (rank : 75)	NC score	0.165534 (rank : 69)
Query Neighborhood Hits	88	Target Neighborhood Hits	198	Shared Neighborhood Hits	64
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NTBP1_MOUSE
θ value	4.03905 (rank : 76)	NC score	0.028013 (rank : 183)
Query Neighborhood Hits	88	Target Neighborhood Hits	528	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BRM2, Q8CAA8	Gene names	Scyl1bp1, Ntklbp1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like-binding protein 1 (NTKL-binding protein 1) (NTKL-BP1) (mNTKL-BP1) (SCY1-like 1-binding protein 1) (SCYL1-binding protein 1) (SCYL1-BP1).

ANM2_MOUSE
θ value	5.27518 (rank : 77)	NC score	0.091398 (rank : 133)
Query Neighborhood Hits	88	Target Neighborhood Hits	175	Shared Neighborhood Hits	61
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

CD2AP_MOUSE
θ value	5.27518 (rank : 78)	NC score	0.247342 (rank : 29)
Query Neighborhood Hits	88	Target Neighborhood Hits	336	Shared Neighborhood Hits	72
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

MAP4_MOUSE
θ value	5.27518 (rank : 79)	NC score	0.009650 (rank : 191)
Query Neighborhood Hits	88	Target Neighborhood Hits	409	Shared Neighborhood Hits	5
SwissProt Accessions	P27546	Gene names	Map4, Mtap4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

NCF1_MOUSE
θ value	5.27518 (rank : 80)	NC score	0.175391 (rank : 58)
Query Neighborhood Hits	88	Target Neighborhood Hits	198	Shared Neighborhood Hits	68
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

SNX18_HUMAN
θ value	5.27518 (rank : 81)	NC score	0.218933 (rank : 41)
Query Neighborhood Hits	88	Target Neighborhood Hits	207	Shared Neighborhood Hits	63
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

ASPP1_HUMAN
θ value	6.88961 (rank : 82)	NC score	0.096728 (rank : 128)
Query Neighborhood Hits	88	Target Neighborhood Hits	956	Shared Neighborhood Hits	69
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

S3TC2_MOUSE
θ value	6.88961 (rank : 83)	NC score	0.032926 (rank : 180)
Query Neighborhood Hits	88	Target Neighborhood Hits	83	Shared Neighborhood Hits	22
SwissProt Accessions	Q80VA5, Q8BWH2, Q8BXB8, Q8C0G6	Gene names	Sh3tc2, Kiaa1985
Domain Architecture
Description	SH3 domain and tetratricopeptide repeats-containing protein 2.

ASPP1_MOUSE
θ value	8.99809 (rank : 84)	NC score	0.097706 (rank : 124)
Query Neighborhood Hits	88	Target Neighborhood Hits	1244	Shared Neighborhood Hits	70
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BBS2_HUMAN
θ value	8.99809 (rank : 85)	NC score	0.018612 (rank : 187)
Query Neighborhood Hits	88	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BXC9, Q96CM0, Q96SN9	Gene names	BBS2
Domain Architecture	No domain graphic available
Description	Bardet-Biedl syndrome 2 protein.

GRB2_HUMAN
θ value	8.99809 (rank : 86)	NC score	0.195799 (rank : 49)
Query Neighborhood Hits	88	Target Neighborhood Hits	310	Shared Neighborhood Hits	69
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	8.99809 (rank : 87)	NC score	0.195283 (rank : 50)
Query Neighborhood Hits	88	Target Neighborhood Hits	312	Shared Neighborhood Hits	69
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

MYO1E_HUMAN
θ value	8.99809 (rank : 88)	NC score	0.080136 (rank : 144)
Query Neighborhood Hits	88	Target Neighborhood Hits	293	Shared Neighborhood Hits	67
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

ABI1_HUMAN
θ value	θ > 10 (rank : 89)	NC score	0.173962 (rank : 60)
Query Neighborhood Hits	88	Target Neighborhood Hits	257	Shared Neighborhood Hits	62
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 90)	NC score	0.180204 (rank : 57)
Query Neighborhood Hits	88	Target Neighborhood Hits	246	Shared Neighborhood Hits	62
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI2_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.186251 (rank : 55)
Query Neighborhood Hits	88	Target Neighborhood Hits	350	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ABI2_MOUSE
θ value	θ > 10 (rank : 92)	NC score	0.187494 (rank : 53)
Query Neighborhood Hits	88	Target Neighborhood Hits	266	Shared Neighborhood Hits	63
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

ABI3_HUMAN
θ value	θ > 10 (rank : 93)	NC score	0.173935 (rank : 61)
Query Neighborhood Hits	88	Target Neighborhood Hits	227	Shared Neighborhood Hits	57
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 94)	NC score	0.167054 (rank : 67)
Query Neighborhood Hits	88	Target Neighborhood Hits	227	Shared Neighborhood Hits	58
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

AHI1_HUMAN
θ value	θ > 10 (rank : 95)	NC score	0.122033 (rank : 106)
Query Neighborhood Hits	88	Target Neighborhood Hits	537	Shared Neighborhood Hits	68
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

ANM2_HUMAN
θ value	θ > 10 (rank : 96)	NC score	0.082775 (rank : 141)
Query Neighborhood Hits	88	Target Neighborhood Hits	175	Shared Neighborhood Hits	60
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ARHG3_HUMAN
θ value	θ > 10 (rank : 97)	NC score	0.051315 (rank : 175)
Query Neighborhood Hits	88	Target Neighborhood Hits	82	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
θ value	θ > 10 (rank : 98)	NC score	0.050880 (rank : 176)
Query Neighborhood Hits	88	Target Neighborhood Hits	85	Shared Neighborhood Hits	12
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

ARHG4_HUMAN
θ value	θ > 10 (rank : 99)	NC score	0.125706 (rank : 104)
Query Neighborhood Hits	88	Target Neighborhood Hits	242	Shared Neighborhood Hits	57
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	θ > 10 (rank : 100)	NC score	0.105015 (rank : 122)
Query Neighborhood Hits	88	Target Neighborhood Hits	185	Shared Neighborhood Hits	48
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG5_HUMAN
θ value	θ > 10 (rank : 101)	NC score	0.097200 (rank : 127)
Query Neighborhood Hits	88	Target Neighborhood Hits	172	Shared Neighborhood Hits	41
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ARHG6_HUMAN
θ value	θ > 10 (rank : 102)	NC score	0.150060 (rank : 92)
Query Neighborhood Hits	88	Target Neighborhood Hits	376	Shared Neighborhood Hits	67
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG6_MOUSE
θ value	θ > 10 (rank : 103)	NC score	0.152902 (rank : 88)
Query Neighborhood Hits	88	Target Neighborhood Hits	394	Shared Neighborhood Hits	69
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

ARHG7_HUMAN
θ value	θ > 10 (rank : 104)	NC score	0.153128 (rank : 87)
Query Neighborhood Hits	88	Target Neighborhood Hits	347	Shared Neighborhood Hits	67
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG7_MOUSE
θ value	θ > 10 (rank : 105)	NC score	0.157145 (rank : 79)
Query Neighborhood Hits	88	Target Neighborhood Hits	396	Shared Neighborhood Hits	68
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG9_HUMAN
θ value	θ > 10 (rank : 106)	NC score	0.119389 (rank : 110)
Query Neighborhood Hits	88	Target Neighborhood Hits	235	Shared Neighborhood Hits	55
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 107)	NC score	0.119244 (rank : 112)
Query Neighborhood Hits	88	Target Neighborhood Hits	234	Shared Neighborhood Hits	55
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ARHGG_HUMAN
θ value	θ > 10 (rank : 108)	NC score	0.053314 (rank : 172)
Query Neighborhood Hits	88	Target Neighborhood Hits	129	Shared Neighborhood Hits	23
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ARHGG_MOUSE
θ value	θ > 10 (rank : 109)	NC score	0.056294 (rank : 165)
Query Neighborhood Hits	88	Target Neighborhood Hits	152	Shared Neighborhood Hits	28
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

ASPP2_HUMAN
θ value	θ > 10 (rank : 110)	NC score	0.068759 (rank : 150)
Query Neighborhood Hits	88	Target Neighborhood Hits	1156	Shared Neighborhood Hits	51
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

BAIP2_HUMAN
θ value	θ > 10 (rank : 111)	NC score	0.059288 (rank : 158)
Query Neighborhood Hits	88	Target Neighborhood Hits	192	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
θ value	θ > 10 (rank : 112)	NC score	0.059207 (rank : 159)
Query Neighborhood Hits	88	Target Neighborhood Hits	185	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

BCAR1_HUMAN
θ value	θ > 10 (rank : 113)	NC score	0.121189 (rank : 108)
Query Neighborhood Hits	88	Target Neighborhood Hits	554	Shared Neighborhood Hits	66
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	θ > 10 (rank : 114)	NC score	0.119136 (rank : 114)
Query Neighborhood Hits	88	Target Neighborhood Hits	438	Shared Neighborhood Hits	64
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BIN1_HUMAN
θ value	θ > 10 (rank : 115)	NC score	0.053969 (rank : 169)
Query Neighborhood Hits	88	Target Neighborhood Hits	335	Shared Neighborhood Hits	31
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

BIN1_MOUSE
θ value	θ > 10 (rank : 116)	NC score	0.058086 (rank : 162)
Query Neighborhood Hits	88	Target Neighborhood Hits	283	Shared Neighborhood Hits	34
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

CASL_HUMAN
θ value	θ > 10 (rank : 117)	NC score	0.118301 (rank : 115)
Query Neighborhood Hits	88	Target Neighborhood Hits	259	Shared Neighborhood Hits	62
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
θ value	θ > 10 (rank : 118)	NC score	0.117143 (rank : 116)
Query Neighborhood Hits	88	Target Neighborhood Hits	225	Shared Neighborhood Hits	62
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CD2AP_HUMAN
θ value	θ > 10 (rank : 119)	NC score	0.216113 (rank : 44)
Query Neighborhood Hits	88	Target Neighborhood Hits	315	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

CIP4_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.056616 (rank : 164)
Query Neighborhood Hits	88	Target Neighborhood Hits	374	Shared Neighborhood Hits	37
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

CRKL_HUMAN
θ value	θ > 10 (rank : 121)	NC score	0.159690 (rank : 76)
Query Neighborhood Hits	88	Target Neighborhood Hits	313	Shared Neighborhood Hits	66
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRK_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.154727 (rank : 83)
Query Neighborhood Hits	88	Target Neighborhood Hits	308	Shared Neighborhood Hits	67
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
θ value	θ > 10 (rank : 123)	NC score	0.154640 (rank : 84)
Query Neighborhood Hits	88	Target Neighborhood Hits	314	Shared Neighborhood Hits	66
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CT032_HUMAN
θ value	θ > 10 (rank : 124)	NC score	0.145083 (rank : 94)
Query Neighborhood Hits	88	Target Neighborhood Hits	235	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DDEF1_MOUSE
θ value	θ > 10 (rank : 125)	NC score	0.119151 (rank : 113)
Query Neighborhood Hits	88	Target Neighborhood Hits	592	Shared Neighborhood Hits	64
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_HUMAN
θ value	θ > 10 (rank : 126)	NC score	0.086710 (rank : 137)
Query Neighborhood Hits	88	Target Neighborhood Hits	599	Shared Neighborhood Hits	60
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DDEF2_MOUSE
θ value	θ > 10 (rank : 127)	NC score	0.094191 (rank : 131)
Query Neighborhood Hits	88	Target Neighborhood Hits	625	Shared Neighborhood Hits	60
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

EFS_HUMAN
θ value	θ > 10 (rank : 128)	NC score	0.119856 (rank : 109)
Query Neighborhood Hits	88	Target Neighborhood Hits	348	Shared Neighborhood Hits	63
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	θ > 10 (rank : 129)	NC score	0.119273 (rank : 111)
Query Neighborhood Hits	88	Target Neighborhood Hits	389	Shared Neighborhood Hits	63
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

EPS8_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.108438 (rank : 120)
Query Neighborhood Hits	88	Target Neighborhood Hits	151	Shared Neighborhood Hits	52
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_MOUSE
θ value	θ > 10 (rank : 131)	NC score	0.108831 (rank : 119)
Query Neighborhood Hits	88	Target Neighborhood Hits	157	Shared Neighborhood Hits	56
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

ES8L1_HUMAN
θ value	θ > 10 (rank : 132)	NC score	0.095128 (rank : 130)
Query Neighborhood Hits	88	Target Neighborhood Hits	162	Shared Neighborhood Hits	51
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

ES8L1_MOUSE
θ value	θ > 10 (rank : 133)	NC score	0.090879 (rank : 134)
Query Neighborhood Hits	88	Target Neighborhood Hits	143	Shared Neighborhood Hits	43
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

FNBP2_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.074975 (rank : 149)
Query Neighborhood Hits	88	Target Neighborhood Hits	432	Shared Neighborhood Hits	61
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

GRAP_HUMAN
θ value	θ > 10 (rank : 135)	NC score	0.171563 (rank : 63)
Query Neighborhood Hits	88	Target Neighborhood Hits	307	Shared Neighborhood Hits	66
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

HCLS1_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.243873 (rank : 31)
Query Neighborhood Hits	88	Target Neighborhood Hits	358	Shared Neighborhood Hits	67
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

IASPP_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.096139 (rank : 129)
Query Neighborhood Hits	88	Target Neighborhood Hits	688	Shared Neighborhood Hits	60
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IASPP_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.085813 (rank : 138)
Query Neighborhood Hits	88	Target Neighborhood Hits	1024	Shared Neighborhood Hits	65
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

MCF2L_MOUSE
θ value	θ > 10 (rank : 139)	NC score	0.054369 (rank : 168)
Query Neighborhood Hits	88	Target Neighborhood Hits	255	Shared Neighborhood Hits	22
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

MYO1F_HUMAN
θ value	θ > 10 (rank : 140)	NC score	0.082397 (rank : 143)
Query Neighborhood Hits	88	Target Neighborhood Hits	275	Shared Neighborhood Hits	69
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1F_MOUSE
θ value	θ > 10 (rank : 141)	NC score	0.082466 (rank : 142)
Query Neighborhood Hits	88	Target Neighborhood Hits	262	Shared Neighborhood Hits	69
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

NCF2_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.221188 (rank : 39)
Query Neighborhood Hits	88	Target Neighborhood Hits	229	Shared Neighborhood Hits	64
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 143)	NC score	0.223529 (rank : 38)
Query Neighborhood Hits	88	Target Neighborhood Hits	161	Shared Neighborhood Hits	57
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 144)	NC score	0.233005 (rank : 36)
Query Neighborhood Hits	88	Target Neighborhood Hits	177	Shared Neighborhood Hits	60
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCK1_HUMAN
θ value	θ > 10 (rank : 145)	NC score	0.144627 (rank : 96)
Query Neighborhood Hits	88	Target Neighborhood Hits	312	Shared Neighborhood Hits	68
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NCK2_HUMAN
θ value	θ > 10 (rank : 146)	NC score	0.157584 (rank : 78)
Query Neighborhood Hits	88	Target Neighborhood Hits	310	Shared Neighborhood Hits	71
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NEBU_HUMAN
θ value	θ > 10 (rank : 147)	NC score	0.142238 (rank : 98)
Query Neighborhood Hits	88	Target Neighborhood Hits	420	Shared Neighborhood Hits	61
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

NGEF_HUMAN
θ value	θ > 10 (rank : 148)	NC score	0.067350 (rank : 153)
Query Neighborhood Hits	88	Target Neighborhood Hits	166	Shared Neighborhood Hits	33
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NGEF_MOUSE
θ value	θ > 10 (rank : 149)	NC score	0.062772 (rank : 157)
Query Neighborhood Hits	88	Target Neighborhood Hits	228	Shared Neighborhood Hits	32
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NOXO1_HUMAN
θ value	θ > 10 (rank : 150)	NC score	0.057541 (rank : 163)
Query Neighborhood Hits	88	Target Neighborhood Hits	100	Shared Neighborhood Hits	34
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 151)	NC score	0.066511 (rank : 154)
Query Neighborhood Hits	88	Target Neighborhood Hits	114	Shared Neighborhood Hits	36
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_HUMAN
θ value	θ > 10 (rank : 152)	NC score	0.091664 (rank : 132)
Query Neighborhood Hits	88	Target Neighborhood Hits	288	Shared Neighborhood Hits	58
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

NPHP1_MOUSE
θ value	θ > 10 (rank : 153)	NC score	0.121262 (rank : 107)
Query Neighborhood Hits	88	Target Neighborhood Hits	267	Shared Neighborhood Hits	66
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

OSTF1_HUMAN
θ value	θ > 10 (rank : 154)	NC score	0.161754 (rank : 74)
Query Neighborhood Hits	88	Target Neighborhood Hits	466	Shared Neighborhood Hits	66
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 155)	NC score	0.155299 (rank : 81)
Query Neighborhood Hits	88	Target Neighborhood Hits	467	Shared Neighborhood Hits	66
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

P85A_HUMAN
θ value	θ > 10 (rank : 156)	NC score	0.053140 (rank : 173)
Query Neighborhood Hits	88	Target Neighborhood Hits	479	Shared Neighborhood Hits	43
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

P85A_MOUSE
θ value	θ > 10 (rank : 157)	NC score	0.058309 (rank : 161)
Query Neighborhood Hits	88	Target Neighborhood Hits	435	Shared Neighborhood Hits	47
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

PACN1_HUMAN
θ value	θ > 10 (rank : 158)	NC score	0.167812 (rank : 66)
Query Neighborhood Hits	88	Target Neighborhood Hits	320	Shared Neighborhood Hits	68
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN1_MOUSE
θ value	θ > 10 (rank : 159)	NC score	0.165502 (rank : 71)
Query Neighborhood Hits	88	Target Neighborhood Hits	283	Shared Neighborhood Hits	68
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
θ value	θ > 10 (rank : 160)	NC score	0.165103 (rank : 72)
Query Neighborhood Hits	88	Target Neighborhood Hits	339	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 161)	NC score	0.157079 (rank : 80)
Query Neighborhood Hits	88	Target Neighborhood Hits	382	Shared Neighborhood Hits	69
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN3_HUMAN
θ value	θ > 10 (rank : 162)	NC score	0.150973 (rank : 90)
Query Neighborhood Hits	88	Target Neighborhood Hits	385	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

PACN3_MOUSE
θ value	θ > 10 (rank : 163)	NC score	0.153188 (rank : 86)
Query Neighborhood Hits	88	Target Neighborhood Hits	380	Shared Neighborhood Hits	69
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

PEX13_HUMAN
θ value	θ > 10 (rank : 164)	NC score	0.111740 (rank : 117)
Query Neighborhood Hits	88	Target Neighborhood Hits	128	Shared Neighborhood Hits	48
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
θ value	θ > 10 (rank : 165)	NC score	0.109072 (rank : 118)
Query Neighborhood Hits	88	Target Neighborhood Hits	126	Shared Neighborhood Hits	47
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PLCG1_HUMAN
θ value	θ > 10 (rank : 166)	NC score	0.089539 (rank : 135)
Query Neighborhood Hits	88	Target Neighborhood Hits	293	Shared Neighborhood Hits	58
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 167)	NC score	0.098226 (rank : 123)
Query Neighborhood Hits	88	Target Neighborhood Hits	314	Shared Neighborhood Hits	61
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 168)	NC score	0.097293 (rank : 126)
Query Neighborhood Hits	88	Target Neighborhood Hits	280	Shared Neighborhood Hits	61
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

RHG04_HUMAN
θ value	θ > 10 (rank : 169)	NC score	0.088805 (rank : 136)
Query Neighborhood Hits	88	Target Neighborhood Hits	307	Shared Neighborhood Hits	61
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

RIMB1_HUMAN
θ value	θ > 10 (rank : 170)	NC score	0.075817 (rank : 146)
Query Neighborhood Hits	88	Target Neighborhood Hits	1479	Shared Neighborhood Hits	56
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB1_MOUSE
θ value	θ > 10 (rank : 171)	NC score	0.068319 (rank : 151)
Query Neighborhood Hits	88	Target Neighborhood Hits	1376	Shared Neighborhood Hits	70
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RIMB2_HUMAN
θ value	θ > 10 (rank : 172)	NC score	0.155204 (rank : 82)
Query Neighborhood Hits	88	Target Neighborhood Hits	263	Shared Neighborhood Hits	52
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

RUSC2_HUMAN
θ value	θ > 10 (rank : 173)	NC score	0.075560 (rank : 147)
Query Neighborhood Hits	88	Target Neighborhood Hits	205	Shared Neighborhood Hits	30
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

RUSC2_MOUSE
θ value	θ > 10 (rank : 174)	NC score	0.065045 (rank : 156)
Query Neighborhood Hits	88	Target Neighborhood Hits	305	Shared Neighborhood Hits	29
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SH3K1_HUMAN
θ value	θ > 10 (rank : 175)	NC score	0.236043 (rank : 33)
Query Neighborhood Hits	88	Target Neighborhood Hits	341	Shared Neighborhood Hits	69
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

SH3K1_MOUSE
θ value	θ > 10 (rank : 176)	NC score	0.233487 (rank : 35)
Query Neighborhood Hits	88	Target Neighborhood Hits	332	Shared Neighborhood Hits	70
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SHAN2_MOUSE
θ value	θ > 10 (rank : 177)	NC score	0.065632 (rank : 155)
Query Neighborhood Hits	88	Target Neighborhood Hits	446	Shared Neighborhood Hits	45
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SPN90_HUMAN
θ value	θ > 10 (rank : 178)	NC score	0.055405 (rank : 167)
Query Neighborhood Hits	88	Target Neighborhood Hits	157	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

SPN90_MOUSE
θ value	θ > 10 (rank : 179)	NC score	0.050223 (rank : 178)
Query Neighborhood Hits	88	Target Neighborhood Hits	157	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

SRGP1_HUMAN
θ value	θ > 10 (rank : 180)	NC score	0.075449 (rank : 148)
Query Neighborhood Hits	88	Target Neighborhood Hits	390	Shared Neighborhood Hits	56
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

SRGP2_HUMAN
θ value	θ > 10 (rank : 181)	NC score	0.083794 (rank : 140)
Query Neighborhood Hits	88	Target Neighborhood Hits	331	Shared Neighborhood Hits	57
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

SRGP2_MOUSE
θ value	θ > 10 (rank : 182)	NC score	0.084448 (rank : 139)
Query Neighborhood Hits	88	Target Neighborhood Hits	324	Shared Neighborhood Hits	57
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

STAC3_HUMAN
θ value	θ > 10 (rank : 183)	NC score	0.135510 (rank : 101)
Query Neighborhood Hits	88	Target Neighborhood Hits	228	Shared Neighborhood Hits	59
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 184)	NC score	0.138194 (rank : 99)
Query Neighborhood Hits	88	Target Neighborhood Hits	232	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC_HUMAN
θ value	θ > 10 (rank : 185)	NC score	0.187894 (rank : 52)
Query Neighborhood Hits	88	Target Neighborhood Hits	276	Shared Neighborhood Hits	63
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
θ value	θ > 10 (rank : 186)	NC score	0.172309 (rank : 62)
Query Neighborhood Hits	88	Target Neighborhood Hits	268	Shared Neighborhood Hits	57
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STS1_HUMAN
θ value	θ > 10 (rank : 187)	NC score	0.050412 (rank : 177)
Query Neighborhood Hits	88	Target Neighborhood Hits	106	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS1_MOUSE
θ value	θ > 10 (rank : 188)	NC score	0.052364 (rank : 174)
Query Neighborhood Hits	88	Target Neighborhood Hits	104	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

STS2_HUMAN
θ value	θ > 10 (rank : 189)	NC score	0.076436 (rank : 145)
Query Neighborhood Hits	88	Target Neighborhood Hits	108	Shared Neighborhood Hits	35
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

TCGAP_HUMAN
θ value	θ > 10 (rank : 190)	NC score	0.058830 (rank : 160)
Query Neighborhood Hits	88	Target Neighborhood Hits	872	Shared Neighborhood Hits	52
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TCGAP_MOUSE
θ value	θ > 10 (rank : 191)	NC score	0.067835 (rank : 152)
Query Neighborhood Hits	88	Target Neighborhood Hits	409	Shared Neighborhood Hits	50
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

Hits sorted by NC score

SHLB2_MOUSE
NC score	0.999962 (rank : 1)	θ value	3.37019e-164 (rank : 2)
Query Neighborhood Hits	88	Target Neighborhood Hits	88	Shared Neighborhood Hits	88
SwissProt Accessions	Q8R3V5, Q8K140, Q91ZI7	Gene names	Sh3glb2, Kiaa1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB2_HUMAN
NC score	0.999275 (rank : 2)	θ value	8.28183e-171 (rank : 1)
Query Neighborhood Hits	88	Target Neighborhood Hits	86	Shared Neighborhood Hits	86
SwissProt Accessions	Q9NR46, Q8WY61, Q96JH9	Gene names	SH3GLB2, KIAA1848
Domain Architecture
Description	SH3 domain GRB2-like protein B2 (Endophilin-B2).

SHLB1_HUMAN
NC score	0.972281 (rank : 3)	θ value	2.44341e-122 (rank : 3)
Query Neighborhood Hits	88	Target Neighborhood Hits	96	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y371, Q9H3Z0, Q9NR47, Q9NYA9	Gene names	SH3GLB1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1) (Bax- interacting factor 1) (Bif-1).

SHLB1_MOUSE
NC score	0.968506 (rank : 4)	θ value	1.63895e-118 (rank : 4)
Query Neighborhood Hits	88	Target Neighborhood Hits	101	Shared Neighborhood Hits	65
SwissProt Accessions	Q9JK48, Q8CDS9, Q8VI52, Q9CT31	Gene names	Sh3glb1
Domain Architecture
Description	SH3 domain GRB2-like protein B1 (EC 2.3.1.-) (Endophilin-B1).

SH3G1_HUMAN
NC score	0.648945 (rank : 5)	θ value	8.36355e-22 (rank : 5)
Query Neighborhood Hits	88	Target Neighborhood Hits	307	Shared Neighborhood Hits	72
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
NC score	0.643682 (rank : 6)	θ value	5.42112e-21 (rank : 6)
Query Neighborhood Hits	88	Target Neighborhood Hits	291	Shared Neighborhood Hits	73
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_MOUSE
NC score	0.624066 (rank : 7)	θ value	2.5182e-18 (rank : 8)
Query Neighborhood Hits	88	Target Neighborhood Hits	319	Shared Neighborhood Hits	71
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SH3G2_HUMAN
NC score	0.623094 (rank : 8)	θ value	1.02238e-19 (rank : 7)
Query Neighborhood Hits	88	Target Neighborhood Hits	324	Shared Neighborhood Hits	71
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G3_HUMAN
NC score	0.622612 (rank : 9)	θ value	2.20605e-14 (rank : 10)
Query Neighborhood Hits	88	Target Neighborhood Hits	222	Shared Neighborhood Hits	70
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SH3G3_MOUSE
NC score	0.617962 (rank : 10)	θ value	5.8054e-15 (rank : 9)
Query Neighborhood Hits	88	Target Neighborhood Hits	236	Shared Neighborhood Hits	71
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SRBS1_HUMAN
NC score	0.312094 (rank : 11)	θ value	0.00509761 (rank : 26)
Query Neighborhood Hits	88	Target Neighborhood Hits	396	Shared Neighborhood Hits	70
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

STAM1_HUMAN
NC score	0.298208 (rank : 12)	θ value	0.000461057 (rank : 13)
Query Neighborhood Hits	88	Target Neighborhood Hits	271	Shared Neighborhood Hits	73
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
NC score	0.297400 (rank : 13)	θ value	0.000461057 (rank : 14)
Query Neighborhood Hits	88	Target Neighborhood Hits	273	Shared Neighborhood Hits	73
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

SRBS1_MOUSE
NC score	0.296849 (rank : 14)	θ value	0.0148317 (rank : 31)
Query Neighborhood Hits	88	Target Neighborhood Hits	409	Shared Neighborhood Hits	72
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

VINEX_MOUSE
NC score	0.292927 (rank : 15)	θ value	0.47712 (rank : 54)
Query Neighborhood Hits	88	Target Neighborhood Hits	286	Shared Neighborhood Hits	73
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

VINEX_HUMAN
NC score	0.286575 (rank : 16)	θ value	0.62314 (rank : 57)
Query Neighborhood Hits	88	Target Neighborhood Hits	270	Shared Neighborhood Hits	71
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

PPIP1_HUMAN
NC score	0.283898 (rank : 17)	θ value	0.000158464 (rank : 12)
Query Neighborhood Hits	88	Target Neighborhood Hits	389	Shared Neighborhood Hits	73
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
NC score	0.283176 (rank : 18)	θ value	0.00228821 (rank : 20)
Query Neighborhood Hits	88	Target Neighborhood Hits	377	Shared Neighborhood Hits	75
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

DBNL_HUMAN
NC score	0.279144 (rank : 19)	θ value	0.163984 (rank : 40)
Query Neighborhood Hits	88	Target Neighborhood Hits	244	Shared Neighborhood Hits	68
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
NC score	0.276308 (rank : 20)	θ value	0.163984 (rank : 41)
Query Neighborhood Hits	88	Target Neighborhood Hits	306	Shared Neighborhood Hits	68
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

STAM2_MOUSE
NC score	0.275317 (rank : 21)	θ value	0.0113563 (rank : 30)
Query Neighborhood Hits	88	Target Neighborhood Hits	285	Shared Neighborhood Hits	73
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

LASP1_HUMAN
NC score	0.275012 (rank : 22)	θ value	0.00298849 (rank : 22)
Query Neighborhood Hits	88	Target Neighborhood Hits	293	Shared Neighborhood Hits	65
SwissProt Accessions	Q14847, Q96ED2, Q96IG0	Gene names	LASP1, MLN50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

LASP1_MOUSE
NC score	0.270692 (rank : 23)	θ value	0.00298849 (rank : 23)
Query Neighborhood Hits	88	Target Neighborhood Hits	297	Shared Neighborhood Hits	65
SwissProt Accessions	Q61792, Q62416	Gene names	Lasp1, Mln50
Domain Architecture
Description	LIM and SH3 domain protein 1 (LASP-1) (MLN 50).

SRC8_HUMAN
NC score	0.269031 (rank : 24)	θ value	0.21417 (rank : 44)
Query Neighborhood Hits	88	Target Neighborhood Hits	269	Shared Neighborhood Hits	70
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
NC score	0.264747 (rank : 25)	θ value	0.21417 (rank : 45)
Query Neighborhood Hits	88	Target Neighborhood Hits	292	Shared Neighborhood Hits	72
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

HCLS1_MOUSE
NC score	0.262272 (rank : 26)	θ value	0.813845 (rank : 58)
Query Neighborhood Hits	88	Target Neighborhood Hits	329	Shared Neighborhood Hits	71
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

STAM2_HUMAN
NC score	0.257779 (rank : 27)	θ value	0.125558 (rank : 39)
Query Neighborhood Hits	88	Target Neighborhood Hits	288	Shared Neighborhood Hits	72
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

RUSC1_HUMAN
NC score	0.253809 (rank : 28)	θ value	0.000786445 (rank : 15)
Query Neighborhood Hits	88	Target Neighborhood Hits	226	Shared Neighborhood Hits	58
SwissProt Accessions	Q9BVN2, Q9UPY4, Q9Y4T5	Gene names	RUSC1, NESCA
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1 (New molecule containing SH3 at the carboxy-terminus) (Nesca).

CD2AP_MOUSE
NC score	0.247342 (rank : 29)	θ value	5.27518 (rank : 78)
Query Neighborhood Hits	88	Target Neighborhood Hits	336	Shared Neighborhood Hits	72
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

RUSC1_MOUSE
NC score	0.244464 (rank : 30)	θ value	0.00869519 (rank : 29)
Query Neighborhood Hits	88	Target Neighborhood Hits	206	Shared Neighborhood Hits	53
SwissProt Accessions	Q8BG26, Q6PHT9	Gene names	Rusc1
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 1.

HCLS1_HUMAN
NC score	0.243873 (rank : 31)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	88	Target Neighborhood Hits	358	Shared Neighborhood Hits	67
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

GRAP2_MOUSE
NC score	0.237609 (rank : 32)	θ value	0.00228821 (rank : 19)
Query Neighborhood Hits	88	Target Neighborhood Hits	297	Shared Neighborhood Hits	73
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

SH3K1_HUMAN
NC score	0.236043 (rank : 33)	θ value	θ > 10 (rank : 175)
Query Neighborhood Hits	88	Target Neighborhood Hits	341	Shared Neighborhood Hits	69
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

GRAP2_HUMAN
NC score	0.234415 (rank : 34)	θ value	0.00298849 (rank : 21)
Query Neighborhood Hits	88	Target Neighborhood Hits	304	Shared Neighborhood Hits	72
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

SH3K1_MOUSE
NC score	0.233487 (rank : 35)	θ value	θ > 10 (rank : 176)
Query Neighborhood Hits	88	Target Neighborhood Hits	332	Shared Neighborhood Hits	70
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

NCF4_MOUSE
NC score	0.233005 (rank : 36)	θ value	θ > 10 (rank : 144)
Query Neighborhood Hits	88	Target Neighborhood Hits	177	Shared Neighborhood Hits	60
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

SNX18_MOUSE
NC score	0.225824 (rank : 37)	θ value	3.0926 (rank : 73)
Query Neighborhood Hits	88	Target Neighborhood Hits	198	Shared Neighborhood Hits	63
SwissProt Accessions	Q91ZR2	Gene names	Snag1, Snx18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

NCF4_HUMAN
NC score	0.223529 (rank : 38)	θ value	θ > 10 (rank : 143)
Query Neighborhood Hits	88	Target Neighborhood Hits	161	Shared Neighborhood Hits	57
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF2_HUMAN
NC score	0.221188 (rank : 39)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	88	Target Neighborhood Hits	229	Shared Neighborhood Hits	64
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

DNMBP_MOUSE
NC score	0.219188 (rank : 40)	θ value	0.62314 (rank : 55)
Query Neighborhood Hits	88	Target Neighborhood Hits	435	Shared Neighborhood Hits	76
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

SNX18_HUMAN
NC score	0.218933 (rank : 41)	θ value	5.27518 (rank : 81)
Query Neighborhood Hits	88	Target Neighborhood Hits	207	Shared Neighborhood Hits	63
SwissProt Accessions	Q96RF0	Gene names	SNAG1, SNX18
Domain Architecture
Description	Sorting nexin-18 (Sorting nexin-associated Golgi protein 1).

DNMBP_HUMAN
NC score	0.216890 (rank : 42)	θ value	1.38821 (rank : 61)
Query Neighborhood Hits	88	Target Neighborhood Hits	413	Shared Neighborhood Hits	76
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

NEBL_HUMAN
NC score	0.216327 (rank : 43)	θ value	0.47712 (rank : 50)
Query Neighborhood Hits	88	Target Neighborhood Hits	457	Shared Neighborhood Hits	64
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

CD2AP_HUMAN
NC score	0.216113 (rank : 44)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	88	Target Neighborhood Hits	315	Shared Neighborhood Hits	70
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SNX9_MOUSE
NC score	0.212289 (rank : 45)	θ value	0.0252991 (rank : 34)
Query Neighborhood Hits	88	Target Neighborhood Hits	141	Shared Neighborhood Hits	46
SwissProt Accessions	Q91VH2	Gene names	Snx9
Domain Architecture
Description	Sorting nexin-9.

VAV2_MOUSE
NC score	0.210805 (rank : 46)	θ value	0.000121331 (rank : 11)
Query Neighborhood Hits	88	Target Neighborhood Hits	456	Shared Neighborhood Hits	69
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

SNX9_HUMAN
NC score	0.209506 (rank : 47)	θ value	0.125558 (rank : 38)
Query Neighborhood Hits	88	Target Neighborhood Hits	148	Shared Neighborhood Hits	45
SwissProt Accessions	Q9Y5X1, Q9BSI7, Q9BVM1, Q9UJH6, Q9UP20	Gene names	SNX9, SH3PX1
Domain Architecture
Description	Sorting nexin-9 (SH3 and PX domain-containing protein 1) (SDP1 protein).

VAV2_HUMAN
NC score	0.206344 (rank : 48)	θ value	0.00134147 (rank : 17)
Query Neighborhood Hits	88	Target Neighborhood Hits	453	Shared Neighborhood Hits	69
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

GRB2_HUMAN
NC score	0.195799 (rank : 49)	θ value	8.99809 (rank : 86)
Query Neighborhood Hits	88	Target Neighborhood Hits	310	Shared Neighborhood Hits	69
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
NC score	0.195283 (rank : 50)	θ value	8.99809 (rank : 87)
Query Neighborhood Hits	88	Target Neighborhood Hits	312	Shared Neighborhood Hits	69
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

VAV_MOUSE
NC score	0.188193 (rank : 51)	θ value	0.279714 (rank : 47)
Query Neighborhood Hits	88	Target Neighborhood Hits	430	Shared Neighborhood Hits	67
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

STAC_HUMAN
NC score	0.187894 (rank : 52)	θ value	θ > 10 (rank : 185)
Query Neighborhood Hits	88	Target Neighborhood Hits	276	Shared Neighborhood Hits	63
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ABI2_MOUSE
NC score	0.187494 (rank : 53)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	88	Target Neighborhood Hits	266	Shared Neighborhood Hits	63
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

GRAP_MOUSE
NC score	0.187078 (rank : 54)	θ value	0.21417 (rank : 42)
Query Neighborhood Hits	88	Target Neighborhood Hits	309	Shared Neighborhood Hits	68
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

ABI2_HUMAN
NC score	0.186251 (rank : 55)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	88	Target Neighborhood Hits	350	Shared Neighborhood Hits	63
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

VAV_HUMAN
NC score	0.184821 (rank : 56)	θ value	0.279714 (rank : 46)
Query Neighborhood Hits	88	Target Neighborhood Hits	452	Shared Neighborhood Hits	67
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ABI1_MOUSE
NC score	0.180204 (rank : 57)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	88	Target Neighborhood Hits	246	Shared Neighborhood Hits	62
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

NCF1_MOUSE
NC score	0.175391 (rank : 58)	θ value	5.27518 (rank : 80)
Query Neighborhood Hits	88	Target Neighborhood Hits	198	Shared Neighborhood Hits	68
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

CRKL_MOUSE
NC score	0.174301 (rank : 59)	θ value	0.125558 (rank : 37)
Query Neighborhood Hits	88	Target Neighborhood Hits	307	Shared Neighborhood Hits	66
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

ABI1_HUMAN
NC score	0.173962 (rank : 60)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	88	Target Neighborhood Hits	257	Shared Neighborhood Hits	62
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI3_HUMAN
NC score	0.173935 (rank : 61)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	88	Target Neighborhood Hits	227	Shared Neighborhood Hits	57
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

STAC_MOUSE
NC score	0.172309 (rank : 62)	θ value	θ > 10 (rank : 186)
Query Neighborhood Hits	88	Target Neighborhood Hits	268	Shared Neighborhood Hits	57
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

GRAP_HUMAN
NC score	0.171563 (rank : 63)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	88	Target Neighborhood Hits	307	Shared Neighborhood Hits	66
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

RIMB2_MOUSE
NC score	0.169284 (rank : 64)	θ value	0.813845 (rank : 59)
Query Neighborhood Hits	88	Target Neighborhood Hits	246	Shared Neighborhood Hits	49
SwissProt Accessions	Q80U40	Gene names	Rimbp2, Kiaa0318, Rbp2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

VAV3_HUMAN
NC score	0.168013 (rank : 65)	θ value	0.47712 (rank : 53)
Query Neighborhood Hits	88	Target Neighborhood Hits	398	Shared Neighborhood Hits	69
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

PACN1_HUMAN
NC score	0.167812 (rank : 66)	θ value	θ > 10 (rank : 158)
Query Neighborhood Hits	88	Target Neighborhood Hits	320	Shared Neighborhood Hits	68
SwissProt Accessions	Q9BY11, Q9P2G8	Gene names	PACSIN1, KIAA1379
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

ABI3_MOUSE
NC score	0.167054 (rank : 67)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	88	Target Neighborhood Hits	227	Shared Neighborhood Hits	58
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ITSN1_HUMAN
NC score	0.166988 (rank : 68)	θ value	0.00134147 (rank : 16)
Query Neighborhood Hits	88	Target Neighborhood Hits	1757	Shared Neighborhood Hits	82
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

NCF1_HUMAN
NC score	0.165534 (rank : 69)	θ value	4.03905 (rank : 75)
Query Neighborhood Hits	88	Target Neighborhood Hits	198	Shared Neighborhood Hits	64
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

ITSN1_MOUSE
NC score	0.165527 (rank : 70)	θ value	0.00869519 (rank : 28)
Query Neighborhood Hits	88	Target Neighborhood Hits	1669	Shared Neighborhood Hits	82
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

PACN1_MOUSE
NC score	0.165502 (rank : 71)	θ value	θ > 10 (rank : 159)
Query Neighborhood Hits	88	Target Neighborhood Hits	283	Shared Neighborhood Hits	68
SwissProt Accessions	Q61644	Gene names	Pacsin1, Pacsin
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 1.

PACN2_HUMAN
NC score	0.165103 (rank : 72)	θ value	θ > 10 (rank : 160)
Query Neighborhood Hits	88	Target Neighborhood Hits	339	Shared Neighborhood Hits	71
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

VAV3_MOUSE
NC score	0.165063 (rank : 73)	θ value	0.365318 (rank : 49)
Query Neighborhood Hits	88	Target Neighborhood Hits	404	Shared Neighborhood Hits	67
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

OSTF1_HUMAN
NC score	0.161754 (rank : 74)	θ value	θ > 10 (rank : 154)
Query Neighborhood Hits	88	Target Neighborhood Hits	466	Shared Neighborhood Hits	66
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

ES8L2_MOUSE
NC score	0.160010 (rank : 75)	θ value	0.0252991 (rank : 33)
Query Neighborhood Hits	88	Target Neighborhood Hits	169	Shared Neighborhood Hits	52
SwissProt Accessions	Q99K30, Q91VT7	Gene names	Eps8l2, Eps8r2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

CRKL_HUMAN
NC score	0.159690 (rank : 76)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	88	Target Neighborhood Hits	313	Shared Neighborhood Hits	66
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

ITSN2_HUMAN
NC score	0.158708 (rank : 77)	θ value	1.81305 (rank : 66)
Query Neighborhood Hits	88	Target Neighborhood Hits	1173	Shared Neighborhood Hits	75
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

NCK2_HUMAN
NC score	0.157584 (rank : 78)	θ value	θ > 10 (rank : 146)
Query Neighborhood Hits	88	Target Neighborhood Hits	310	Shared Neighborhood Hits	71
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

ARHG7_MOUSE
NC score	0.157145 (rank : 79)	θ value	θ > 10 (rank : 105)
Query Neighborhood Hits	88	Target Neighborhood Hits	396	Shared Neighborhood Hits	68
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

PACN2_MOUSE
NC score	0.157079 (rank : 80)	θ value	θ > 10 (rank : 161)
Query Neighborhood Hits	88	Target Neighborhood Hits	382	Shared Neighborhood Hits	69
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

OSTF1_MOUSE
NC score	0.155299 (rank : 81)	θ value	θ > 10 (rank : 155)
Query Neighborhood Hits	88	Target Neighborhood Hits	467	Shared Neighborhood Hits	66
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

RIMB2_HUMAN
NC score	0.155204 (rank : 82)	θ value	θ > 10 (rank : 172)
Query Neighborhood Hits	88	Target Neighborhood Hits	263	Shared Neighborhood Hits	52
SwissProt Accessions	O15034, Q96ID2	Gene names	RIMBP2, KIAA0318, RBP2
Domain Architecture
Description	RIM-binding protein 2 (RIM-BP2).

CRK_HUMAN
NC score	0.154727 (rank : 83)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	88	Target Neighborhood Hits	308	Shared Neighborhood Hits	67
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRK_MOUSE
NC score	0.154640 (rank : 84)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	88	Target Neighborhood Hits	314	Shared Neighborhood Hits	66
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

ES8L3_MOUSE
NC score	0.154154 (rank : 85)	θ value	1.38821 (rank : 62)
Query Neighborhood Hits	88	Target Neighborhood Hits	168	Shared Neighborhood Hits	61
SwissProt Accessions	Q91WL0, Q3TJ14	Gene names	Eps8l3, Eps8r3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor pathway substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

PACN3_MOUSE
NC score	0.153188 (rank : 86)	θ value	θ > 10 (rank : 163)
Query Neighborhood Hits	88	Target Neighborhood Hits	380	Shared Neighborhood Hits	69
SwissProt Accessions	Q99JB8, Q9EQP9	Gene names	Pacsin3
Domain Architecture
Description	Protein kinase C and casein kinase II substrate protein 3.

ARHG7_HUMAN
NC score	0.153128 (rank : 87)	θ value	θ > 10 (rank : 104)
Query Neighborhood Hits	88	Target Neighborhood Hits	347	Shared Neighborhood Hits	67
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

ARHG6_MOUSE
NC score	0.152902 (rank : 88)	θ value	θ > 10 (rank : 103)
Query Neighborhood Hits	88	Target Neighborhood Hits	394	Shared Neighborhood Hits	69
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

SPTA1_MOUSE
NC score	0.152157 (rank : 89)	θ value	0.00509761 (rank : 25)
Query Neighborhood Hits	88	Target Neighborhood Hits	675	Shared Neighborhood Hits	74
SwissProt Accessions	P08032, P97502	Gene names	Spta1, Spna1, Spta
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

PACN3_HUMAN
NC score	0.150973 (rank : 90)	θ value	θ > 10 (rank : 162)
Query Neighborhood Hits	88	Target Neighborhood Hits	385	Shared Neighborhood Hits	70
SwissProt Accessions	Q9UKS6, Q9H331, Q9NWV9	Gene names	PACSIN3
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) (Endophilin I).

ITSN2_MOUSE
NC score	0.150118 (rank : 91)	θ value	0.21417 (rank : 43)
Query Neighborhood Hits	88	Target Neighborhood Hits	1371	Shared Neighborhood Hits	78
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

ARHG6_HUMAN
NC score	0.150060 (rank : 92)	θ value	θ > 10 (rank : 102)
Query Neighborhood Hits	88	Target Neighborhood Hits	376	Shared Neighborhood Hits	67
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

RHG26_HUMAN
NC score	0.148334 (rank : 93)	θ value	0.0193708 (rank : 32)
Query Neighborhood Hits	88	Target Neighborhood Hits	281	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UNA1, O75117, Q9BYS6, Q9BYS7, Q9UJ00	Gene names	ARHGAP26, GRAF, KIAA0621, OPHN1L
Domain Architecture
Description	Rho-GTPase-activating protein 26 (Oligophrenin-1-like protein) (GTPase regulator associated with focal adhesion kinase).

CT032_HUMAN
NC score	0.145083 (rank : 94)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	88	Target Neighborhood Hits	235	Shared Neighborhood Hits	55
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

ES8L2_HUMAN
NC score	0.144668 (rank : 95)	θ value	0.0431538 (rank : 36)
Query Neighborhood Hits	88	Target Neighborhood Hits	193	Shared Neighborhood Hits	55
SwissProt Accessions	Q9H6S3, Q53GM8, Q8WYW7, Q96K06, Q9H6K9	Gene names	EPS8L2, EPS8R2
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 2 (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-like protein 2).

NCK1_HUMAN
NC score	0.144627 (rank : 96)	θ value	θ > 10 (rank : 145)
Query Neighborhood Hits	88	Target Neighborhood Hits	312	Shared Neighborhood Hits	68
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

ES8L3_HUMAN
NC score	0.144171 (rank : 97)	θ value	0.62314 (rank : 56)
Query Neighborhood Hits	88	Target Neighborhood Hits	206	Shared Neighborhood Hits	56
SwissProt Accessions	Q8TE67, Q5T8Q6, Q5T8Q7, Q5T8Q8, Q96E47, Q9H719	Gene names	EPS8L3, EPS8R3
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 3 (Epidermal growth factor receptor pathway substrate 8-related protein 3) (EPS8-like protein 3).

NEBU_HUMAN
NC score	0.142238 (rank : 98)	θ value	θ > 10 (rank : 147)
Query Neighborhood Hits	88	Target Neighborhood Hits	420	Shared Neighborhood Hits	61
SwissProt Accessions	P20929, Q15346	Gene names	NEB
Domain Architecture
Description	Nebulin.

STAC3_MOUSE
NC score	0.138194 (rank : 99)	θ value	θ > 10 (rank : 184)
Query Neighborhood Hits	88	Target Neighborhood Hits	232	Shared Neighborhood Hits	59
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

AHI1_MOUSE
NC score	0.136315 (rank : 100)	θ value	3.0926 (rank : 71)
Query Neighborhood Hits	88	Target Neighborhood Hits	496	Shared Neighborhood Hits	69
SwissProt Accessions	Q8K3E5, Q7TNV2, Q9CVY1	Gene names	Ahi1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein) (AHI-1).

STAC3_HUMAN
NC score	0.135510 (rank : 101)	θ value	θ > 10 (rank : 183)
Query Neighborhood Hits	88	Target Neighborhood Hits	228	Shared Neighborhood Hits	59
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

SPTA1_HUMAN
NC score	0.128257 (rank : 102)	θ value	0.47712 (rank : 52)
Query Neighborhood Hits	88	Target Neighborhood Hits	748	Shared Neighborhood Hits	74
SwissProt Accessions	P02549, Q15514, Q6LDY5	Gene names	SPTA1, SPTA
Domain Architecture
Description	Spectrin alpha chain, erythrocyte (Erythroid alpha-spectrin).

SPTA2_HUMAN
NC score	0.126464 (rank : 103)	θ value	0.00665767 (rank : 27)
Query Neighborhood Hits	88	Target Neighborhood Hits	888	Shared Neighborhood Hits	73
SwissProt Accessions	Q13813, Q13186, Q15324, Q16606, Q59EF1, Q5VXV5, Q5VXV6, Q7Z6M5, Q9P0V0	Gene names	SPTAN1, SPTA2
Domain Architecture
Description	Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain) (Alpha-II spectrin) (Fodrin alpha chain).

ARHG4_HUMAN
NC score	0.125706 (rank : 104)	θ value	θ > 10 (rank : 99)
Query Neighborhood Hits	88	Target Neighborhood Hits	242	Shared Neighborhood Hits	57
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

AMPH_HUMAN
NC score	0.125333 (rank : 105)	θ value	0.0431538 (rank : 35)
Query Neighborhood Hits	88	Target Neighborhood Hits	455	Shared Neighborhood Hits	41
SwissProt Accessions	P49418, O43538, Q75MJ8, Q75MK5, Q75MM3, Q8N4G0	Gene names	AMPH, AMPH1
Domain Architecture
Description	Amphiphysin.

AHI1_HUMAN
NC score	0.122033 (rank : 106)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	88	Target Neighborhood Hits	537	Shared Neighborhood Hits	68
SwissProt Accessions	Q8N157, Q504T3, Q5TCP9, Q6P098, Q6PIT6, Q8NDX0, Q9H0H2	Gene names	AHI1
Domain Architecture	No domain graphic available
Description	Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1).

NPHP1_MOUSE
NC score	0.121262 (rank : 107)	θ value	θ > 10 (rank : 153)
Query Neighborhood Hits	88	Target Neighborhood Hits	267	Shared Neighborhood Hits	66
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

BCAR1_HUMAN
NC score	0.121189 (rank : 108)	θ value	θ > 10 (rank : 113)
Query Neighborhood Hits	88	Target Neighborhood Hits	554	Shared Neighborhood Hits	66
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

EFS_HUMAN
NC score	0.119856 (rank : 109)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	88	Target Neighborhood Hits	348	Shared Neighborhood Hits	63
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

ARHG9_HUMAN
NC score	0.119389 (rank : 110)	θ value	θ > 10 (rank : 106)
Query Neighborhood Hits	88	Target Neighborhood Hits	235	Shared Neighborhood Hits	55
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

EFS_MOUSE
NC score	0.119273 (rank : 111)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	88	Target Neighborhood Hits	389	Shared Neighborhood Hits	63
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

ARHG9_MOUSE
NC score	0.119244 (rank : 112)	θ value	θ > 10 (rank : 107)
Query Neighborhood Hits	88	Target Neighborhood Hits	234	Shared Neighborhood Hits	55
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

DDEF1_MOUSE
NC score	0.119151 (rank : 113)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	88	Target Neighborhood Hits	592	Shared Neighborhood Hits	64
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

BCAR1_MOUSE
NC score	0.119136 (rank : 114)	θ value	θ > 10 (rank : 114)
Query Neighborhood Hits	88	Target Neighborhood Hits	438	Shared Neighborhood Hits	64
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CASL_HUMAN
NC score	0.118301 (rank : 115)	θ value	θ > 10 (rank : 117)
Query Neighborhood Hits	88	Target Neighborhood Hits	259	Shared Neighborhood Hits	62
SwissProt Accessions	Q14511	Gene names	NEDD9, CASL
Domain Architecture
Description	Enhancer of filamentation 1 (HEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (p105) (Protein NEDD9) (NY-REN-12 antigen).

CASL_MOUSE
NC score	0.117143 (rank : 116)	θ value	θ > 10 (rank : 118)
Query Neighborhood Hits	88	Target Neighborhood Hits	225	Shared Neighborhood Hits	62
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

PEX13_HUMAN
NC score	0.111740 (rank : 117)	θ value	θ > 10 (rank : 164)
Query Neighborhood Hits	88	Target Neighborhood Hits	128	Shared Neighborhood Hits	48
SwissProt Accessions	Q92968	Gene names	PEX13
Domain Architecture
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

PEX13_MOUSE
NC score	0.109072 (rank : 118)	θ value	θ > 10 (rank : 165)
Query Neighborhood Hits	88	Target Neighborhood Hits	126	Shared Neighborhood Hits	47
SwissProt Accessions	Q9D0K1, Q3U5T1, Q8CCJ5, Q8CCW5, Q99MM2, Q9EPK1	Gene names	Pex13
Domain Architecture	No domain graphic available
Description	Peroxisomal membrane protein PEX13 (Peroxin-13).

EPS8_MOUSE
NC score	0.108831 (rank : 119)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	88	Target Neighborhood Hits	157	Shared Neighborhood Hits	56
SwissProt Accessions	Q08509	Gene names	Eps8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

EPS8_HUMAN
NC score	0.108438 (rank : 120)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	88	Target Neighborhood Hits	151	Shared Neighborhood Hits	52
SwissProt Accessions	Q12929, Q8N6J0	Gene names	EPS8
Domain Architecture
Description	Epidermal growth factor receptor kinase substrate 8.

3BP1_HUMAN
NC score	0.105175 (rank : 121)	θ value	0.00175202 (rank : 18)
Query Neighborhood Hits	88	Target Neighborhood Hits	376	Shared Neighborhood Hits	21
SwissProt Accessions	Q9Y3L3, Q6IBZ2, Q6ZVL9, Q96HQ5, Q9NSQ9	Gene names	SH3BP1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

ARHG4_MOUSE
NC score	0.105015 (rank : 122)	θ value	θ > 10 (rank : 100)
Query Neighborhood Hits	88	Target Neighborhood Hits	185	Shared Neighborhood Hits	48
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

PLCG1_MOUSE
NC score	0.098226 (rank : 123)	θ value	θ > 10 (rank : 167)
Query Neighborhood Hits	88	Target Neighborhood Hits	314	Shared Neighborhood Hits	61
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

ASPP1_MOUSE
NC score	0.097706 (rank : 124)	θ value	8.99809 (rank : 84)
Query Neighborhood Hits	88	Target Neighborhood Hits	1244	Shared Neighborhood Hits	70
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

AMPH_MOUSE
NC score	0.097435 (rank : 125)	θ value	2.36792 (rank : 68)
Query Neighborhood Hits	88	Target Neighborhood Hits	291	Shared Neighborhood Hits	37
SwissProt Accessions	Q7TQF7, Q8R1C4	Gene names	Amph, Amph1
Domain Architecture
Description	Amphiphysin.

PLCG2_HUMAN
NC score	0.097293 (rank : 126)	θ value	θ > 10 (rank : 168)
Query Neighborhood Hits	88	Target Neighborhood Hits	280	Shared Neighborhood Hits	61
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

ARHG5_HUMAN
NC score	0.097200 (rank : 127)	θ value	θ > 10 (rank : 101)
Query Neighborhood Hits	88	Target Neighborhood Hits	172	Shared Neighborhood Hits	41
SwissProt Accessions	Q12774	Gene names	ARHGEF5, TIM
Domain Architecture
Description	Rho guanine nucleotide exchange factor 5 (Guanine nucleotide regulatory protein TIM) (Oncogene TIM) (p60 TIM) (Transforming immortalized mammary oncogene).

ASPP1_HUMAN
NC score	0.096728 (rank : 128)	θ value	6.88961 (rank : 82)
Query Neighborhood Hits	88	Target Neighborhood Hits	956	Shared Neighborhood Hits	69
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

IASPP_HUMAN
NC score	0.096139 (rank : 129)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	88	Target Neighborhood Hits	688	Shared Neighborhood Hits	60
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ES8L1_HUMAN
NC score	0.095128 (rank : 130)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	88	Target Neighborhood Hits	162	Shared Neighborhood Hits	51
SwissProt Accessions	Q8TE68, Q71RE2, Q8NC10, Q96BB7, Q9BSQ2, Q9GZQ2, Q9NXH0	Gene names	EPS8L1, DRC3, EPS8R1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

DDEF2_MOUSE
NC score	0.094191 (rank : 131)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	88	Target Neighborhood Hits	625	Shared Neighborhood Hits	60
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

NPHP1_HUMAN
NC score	0.091664 (rank : 132)	θ value	θ > 10 (rank : 152)
Query Neighborhood Hits	88	Target Neighborhood Hits	288	Shared Neighborhood Hits	58
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

ANM2_MOUSE
NC score	0.091398 (rank : 133)	θ value	5.27518 (rank : 77)
Query Neighborhood Hits	88	Target Neighborhood Hits	175	Shared Neighborhood Hits	61
SwissProt Accessions	Q9R144	Gene names	Prmt2, Hrmt1l1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

ES8L1_MOUSE
NC score	0.090879 (rank : 134)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	88	Target Neighborhood Hits	143	Shared Neighborhood Hits	43
SwissProt Accessions	Q8R5F8, Q8R0D6, Q9D2M6	Gene names	Eps8l1, Eps8r1
Domain Architecture	No domain graphic available
Description	Epidermal growth factor receptor kinase substrate 8-like protein 1 (Epidermal growth factor receptor pathway substrate 8-related protein 1) (EPS8-like protein 1).

PLCG1_HUMAN
NC score	0.089539 (rank : 135)	θ value	θ > 10 (rank : 166)
Query Neighborhood Hits	88	Target Neighborhood Hits	293	Shared Neighborhood Hits	58
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

RHG04_HUMAN
NC score	0.088805 (rank : 136)	θ value	θ > 10 (rank : 169)
Query Neighborhood Hits	88	Target Neighborhood Hits	307	Shared Neighborhood Hits	61
SwissProt Accessions	P98171, Q14144	Gene names	ARHGAP4, KIAA0131, RGC1, RHOGAP4
Domain Architecture
Description	Rho-GTPase-activating protein 4 (Rho-GAP hematopoietic protein C1) (p115).

DDEF2_HUMAN
NC score	0.086710 (rank : 137)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	88	Target Neighborhood Hits	599	Shared Neighborhood Hits	60
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

IASPP_MOUSE
NC score	0.085813 (rank : 138)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	88	Target Neighborhood Hits	1024	Shared Neighborhood Hits	65
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

SRGP2_MOUSE
NC score	0.084448 (rank : 139)	θ value	θ > 10 (rank : 182)
Query Neighborhood Hits	88	Target Neighborhood Hits	324	Shared Neighborhood Hits	57
SwissProt Accessions	Q812A2, Q80U09, Q8BKP4, Q8BLD0, Q925I2	Gene names	Srgap3, Arhgap14, Kiaa0411, Srgap2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Rho-GTPase-activating protein 14).

SRGP2_HUMAN
NC score	0.083794 (rank : 140)	θ value	θ > 10 (rank : 181)
Query Neighborhood Hits	88	Target Neighborhood Hits	331	Shared Neighborhood Hits	57
SwissProt Accessions	O43295, Q8IX13, Q8IZV8	Gene names	SRGAP3, ARHGAP14, KIAA0411, MEGAP, SRGAP2
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 3 (srGAP3) (srGAP2) (WAVE- associated Rac GTPase-activating protein) (WRP) (Mental disorder- associated GAP) (Rho-GTPase-activating protein 14).

ANM2_HUMAN
NC score	0.082775 (rank : 141)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	88	Target Neighborhood Hits	175	Shared Neighborhood Hits	60
SwissProt Accessions	P55345, P78350, Q9BW15, Q9UMC2	Gene names	PRMT2, HMT1, HRMT1L1
Domain Architecture
Description	Protein arginine N-methyltransferase 2 (EC 2.1.1.-).

MYO1F_MOUSE
NC score	0.082466 (rank : 142)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	88	Target Neighborhood Hits	262	Shared Neighborhood Hits	69
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

MYO1F_HUMAN
NC score	0.082397 (rank : 143)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	88	Target Neighborhood Hits	275	Shared Neighborhood Hits	69
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYO1E_HUMAN
NC score	0.080136 (rank : 144)	θ value	8.99809 (rank : 88)
Query Neighborhood Hits	88	Target Neighborhood Hits	293	Shared Neighborhood Hits	67
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

STS2_HUMAN
NC score	0.076436 (rank : 145)	θ value	θ > 10 (rank : 189)
Query Neighborhood Hits	88	Target Neighborhood Hits	108	Shared Neighborhood Hits	35
SwissProt Accessions	P57075, Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9	Gene names	UBASH3A, STS2
Domain Architecture
Description	Suppressor of T-cell receptor signaling 2 (STS-2) (Cbl-interacting protein 4) (CLIP4) (T-cell ubiquitin ligand) (TULA).

RIMB1_HUMAN
NC score	0.075817 (rank : 146)	θ value	θ > 10 (rank : 170)
Query Neighborhood Hits	88	Target Neighborhood Hits	1479	Shared Neighborhood Hits	56
SwissProt Accessions	O95153, O75111, Q8N5W3	Gene names	BZRAP1, KIAA0612, RBP1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

RUSC2_HUMAN
NC score	0.075560 (rank : 147)	θ value	θ > 10 (rank : 173)
Query Neighborhood Hits	88	Target Neighborhood Hits	205	Shared Neighborhood Hits	30
SwissProt Accessions	Q8N2Y8, O15080, Q6P1W7	Gene names	RUSC2, KIAA0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

SRGP1_HUMAN
NC score	0.075449 (rank : 148)	θ value	θ > 10 (rank : 180)
Query Neighborhood Hits	88	Target Neighborhood Hits	390	Shared Neighborhood Hits	56
SwissProt Accessions	Q7Z6B7, Q9H8A3, Q9P2P2	Gene names	SRGAP1, ARHGAP13, KIAA1304
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho-GTPase- activating protein 13).

FNBP2_HUMAN
NC score	0.074975 (rank : 149)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	88	Target Neighborhood Hits	432	Shared Neighborhood Hits	61
SwissProt Accessions	O75044	Gene names	SRGAP2, FNBP2, KIAA0456
Domain Architecture
Description	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2).

ASPP2_HUMAN
NC score	0.068759 (rank : 150)	θ value	θ > 10 (rank : 110)
Query Neighborhood Hits	88	Target Neighborhood Hits	1156	Shared Neighborhood Hits	51
SwissProt Accessions	Q13625, Q12892, Q86X75, Q96KQ3	Gene names	TP53BP2, ASPP2, BBP
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 2 (Tumor suppressor p53-binding protein 2) (p53-binding protein 2) (p53BP2) (53BP2) (Bcl2-binding protein) (Bbp) (NY-REN-51 antigen).

RIMB1_MOUSE
NC score	0.068319 (rank : 151)	θ value	θ > 10 (rank : 171)
Query Neighborhood Hits	88	Target Neighborhood Hits	1376	Shared Neighborhood Hits	70
SwissProt Accessions	Q7TNF8, Q5NCP7, Q80TV9, Q8BIH5	Gene names	Bzrap1, Kiaa0612, Rbp1
Domain Architecture
Description	Peripheral-type benzodiazepine receptor-associated protein 1 (PRAX-1) (Peripheral benzodiazepine receptor-interacting protein) (PBR-IP) (RIM-binding protein 1) (RIM-BP1).

TCGAP_MOUSE
NC score	0.067835 (rank : 152)	θ value	θ > 10 (rank : 191)
Query Neighborhood Hits	88	Target Neighborhood Hits	409	Shared Neighborhood Hits	50
SwissProt Accessions	Q80YF9, Q6P7W6	Gene names	Snx26, Tcgap
Domain Architecture	No domain graphic available
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

NGEF_HUMAN
NC score	0.067350 (rank : 153)	θ value	θ > 10 (rank : 148)
Query Neighborhood Hits	88	Target Neighborhood Hits	166	Shared Neighborhood Hits	33
SwissProt Accessions	Q8N5V2, Q53QQ4, Q53ST7, Q6GMQ5, Q9NQD6	Gene names	NGEF
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

NOXO1_MOUSE
NC score	0.066511 (rank : 154)	θ value	θ > 10 (rank : 151)
Query Neighborhood Hits	88	Target Neighborhood Hits	114	Shared Neighborhood Hits	36
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

SHAN2_MOUSE
NC score	0.065632 (rank : 155)	θ value	θ > 10 (rank : 177)
Query Neighborhood Hits	88	Target Neighborhood Hits	446	Shared Neighborhood Hits	45
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

RUSC2_MOUSE
NC score	0.065045 (rank : 156)	θ value	θ > 10 (rank : 174)
Query Neighborhood Hits	88	Target Neighborhood Hits	305	Shared Neighborhood Hits	29
SwissProt Accessions	Q80U22, Q8R1D6	Gene names	Rusc2, Kiaa0375
Domain Architecture	No domain graphic available
Description	RUN and SH3 domain-containing protein 2.

NGEF_MOUSE
NC score	0.062772 (rank : 157)	θ value	θ > 10 (rank : 149)
Query Neighborhood Hits	88	Target Neighborhood Hits	228	Shared Neighborhood Hits	32
SwissProt Accessions	Q8CHT1, Q8R204, Q923H2, Q9JHT9	Gene names	Ngef
Domain Architecture	No domain graphic available
Description	Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor).

BAIP2_HUMAN
NC score	0.059288 (rank : 158)	θ value	θ > 10 (rank : 111)
Query Neighborhood Hits	88	Target Neighborhood Hits	192	Shared Neighborhood Hits	31
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

BAIP2_MOUSE
NC score	0.059207 (rank : 159)	θ value	θ > 10 (rank : 112)
Query Neighborhood Hits	88	Target Neighborhood Hits	185	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BKX1, Q91V97, Q923V9, Q923W0	Gene names	Baiap2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor tyrosine kinase 53 kDa substrate).

TCGAP_HUMAN
NC score	0.058830 (rank : 160)	θ value	θ > 10 (rank : 190)
Query Neighborhood Hits	88	Target Neighborhood Hits	872	Shared Neighborhood Hits	52
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

P85A_MOUSE
NC score	0.058309 (rank : 161)	θ value	θ > 10 (rank : 157)
Query Neighborhood Hits	88	Target Neighborhood Hits	435	Shared Neighborhood Hits	47
SwissProt Accessions	P26450	Gene names	Pik3r1
Domain Architecture
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

BIN1_MOUSE
NC score	0.058086 (rank : 162)	θ value	θ > 10 (rank : 116)
Query Neighborhood Hits	88	Target Neighborhood Hits	283	Shared Neighborhood Hits	34
SwissProt Accessions	O08539, Q62434	Gene names	Bin1, Amphl, Sh3p9
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (SH3-domain-containing protein 9).

NOXO1_HUMAN
NC score	0.057541 (rank : 163)	θ value	θ > 10 (rank : 150)
Query Neighborhood Hits	88	Target Neighborhood Hits	100	Shared Neighborhood Hits	34
SwissProt Accessions	Q8NFA2, Q86YM1, Q8NFA3, Q96B73	Gene names	NOXO1, P41NOX
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Nox-organizing protein 1) (NADPH oxidase regulatory protein).

CIP4_HUMAN
NC score	0.056616 (rank : 164)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	88	Target Neighborhood Hits	374	Shared Neighborhood Hits	37
SwissProt Accessions	Q15642, O15184, Q5TZN1	Gene names	TRIP10, CIP4
Domain Architecture
Description	Cdc42-interacting protein 4 (Thyroid receptor-interacting protein 10) (TRIP-10).

ARHGG_MOUSE
NC score	0.056294 (rank : 165)	θ value	θ > 10 (rank : 109)
Query Neighborhood Hits	88	Target Neighborhood Hits	152	Shared Neighborhood Hits	28
SwissProt Accessions	Q3U5C8, Q501M8, Q8VCE8	Gene names	Arhgef16
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

M3KL4_HUMAN
NC score	0.055615 (rank : 166)	θ value	2.36792 (rank : 69)
Query Neighborhood Hits	88	Target Neighborhood Hits	1087	Shared Neighborhood Hits	74
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

SPN90_HUMAN
NC score	0.055405 (rank : 167)	θ value	θ > 10 (rank : 178)
Query Neighborhood Hits	88	Target Neighborhood Hits	157	Shared Neighborhood Hits	36
SwissProt Accessions	Q9NZQ3, Q9UGM8	Gene names	NCKIPSD, AF3P21, SPIN90
Domain Architecture
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (AF3p21) (Diaphanous protein-interacting protein) (Dia-interacting protein 1) (DIP-1).

MCF2L_MOUSE
NC score	0.054369 (rank : 168)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	88	Target Neighborhood Hits	255	Shared Neighborhood Hits	22
SwissProt Accessions	Q64096	Gene names	Mcf2l, Dbs
Domain Architecture
Description	Guanine nucleotide exchange factor DBS (DBL's big sister) (MCF2- transforming sequence-like protein).

BIN1_HUMAN
NC score	0.053969 (rank : 169)	θ value	θ > 10 (rank : 115)
Query Neighborhood Hits	88	Target Neighborhood Hits	335	Shared Neighborhood Hits	31
SwissProt Accessions	O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555, O75514, O75515, O75516, O75517, O75518, Q92944, Q99688	Gene names	BIN1, AMPHL
Domain Architecture
Description	Myc box-dependent-interacting protein 1 (Bridging integrator 1) (Amphiphysin-like protein) (Amphiphysin II) (Box-dependent myc- interacting protein 1).

ORC3_HUMAN
NC score	0.053908 (rank : 170)	θ value	0.365318 (rank : 48)
Query Neighborhood Hits	88	Target Neighborhood Hits	39	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UBD5, Q13565, Q6IUY7, Q9UG44, Q9UNT6	Gene names	ORC3L, LATHEO
Domain Architecture
Description	Origin recognition complex subunit 3 (Origin recognition complex subunit Latheo).

SEGN_MOUSE
NC score	0.053715 (rank : 171)	θ value	0.47712 (rank : 51)
Query Neighborhood Hits	88	Target Neighborhood Hits	101	Shared Neighborhood Hits	8
SwissProt Accessions	Q91WD9	Gene names	Scgn
Domain Architecture
Description	Secretagogin.

ARHGG_HUMAN
NC score	0.053314 (rank : 172)	θ value	θ > 10 (rank : 108)
Query Neighborhood Hits	88	Target Neighborhood Hits	129	Shared Neighborhood Hits	23
SwissProt Accessions	Q5VV41, Q86TF0, Q99434	Gene names	ARHGEF16, NBR
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 16.

P85A_HUMAN
NC score	0.053140 (rank : 173)	θ value	θ > 10 (rank : 156)
Query Neighborhood Hits	88	Target Neighborhood Hits	479	Shared Neighborhood Hits	43
SwissProt Accessions	P27986	Gene names	PIK3R1, GRB1
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase p85-subunit alpha) (PtdIns-3-kinase p85-alpha) (PI3K).

STS1_MOUSE
NC score	0.052364 (rank : 174)	θ value	θ > 10 (rank : 188)
Query Neighborhood Hits	88	Target Neighborhood Hits	104	Shared Neighborhood Hits	29
SwissProt Accessions	Q8BGG7, Q3U8Z2, Q8BMW9	Gene names	Sts1
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

ARHG3_HUMAN
NC score	0.051315 (rank : 175)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	88	Target Neighborhood Hits	82	Shared Neighborhood Hits	12
SwissProt Accessions	Q9NR81, Q6NUN3, Q7Z4U2, Q7Z5T2, Q9H7T4	Gene names	ARHGEF3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3 (Exchange factor found in platelets and leukemic and neuronal tissues) (XPLN).

ARHG3_MOUSE
NC score	0.050880 (rank : 176)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	88	Target Neighborhood Hits	85	Shared Neighborhood Hits	12
SwissProt Accessions	Q91X46, Q8CDM0, Q91VY4, Q99K14, Q9DC31	Gene names	Arhgef3
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 3.

STS1_HUMAN
NC score	0.050412 (rank : 177)	θ value	θ > 10 (rank : 187)
Query Neighborhood Hits	88	Target Neighborhood Hits	106	Shared Neighborhood Hits	29
SwissProt Accessions	Q8TF42, Q53GT5, Q53GT8, Q8NBV7, Q96IG9, Q96NZ2	Gene names	STS1, KIAA1959
Domain Architecture	No domain graphic available
Description	Suppressor of T-cell receptor signaling 1 (Sts-1) (Cbl-interacting protein p70).

SPN90_MOUSE
NC score	0.050223 (rank : 178)	θ value	θ > 10 (rank : 179)
Query Neighborhood Hits	88	Target Neighborhood Hits	157	Shared Neighborhood Hits	35
SwissProt Accessions	Q9ESJ4, Q68G72	Gene names	Nckipsd, Spin90, Wasbp
Domain Architecture	No domain graphic available
Description	SH3 adapter protein SPIN90 (NCK-interacting protein with SH3 domain) (SH3 protein interacting with Nck, 90 kDa) (VacA-interacting protein, 54 kDa) (VIP54) (N-WASP-interacting protein, 90kDa) (Wiskott-Aldrich syndrome protein-binding protein WISH) (N-WASP-binding protein).

3BP1_MOUSE
NC score	0.047455 (rank : 179)	θ value	1.38821 (rank : 60)
Query Neighborhood Hits	88	Target Neighborhood Hits	238	Shared Neighborhood Hits	8
SwissProt Accessions	P55194, Q99KK8	Gene names	Sh3bp1, 3bp1
Domain Architecture
Description	SH3 domain-binding protein 1 (3BP-1).

S3TC2_MOUSE
NC score	0.032926 (rank : 180)	θ value	6.88961 (rank : 83)
Query Neighborhood Hits	88	Target Neighborhood Hits	83	Shared Neighborhood Hits	22
SwissProt Accessions	Q80VA5, Q8BWH2, Q8BXB8, Q8C0G6	Gene names	Sh3tc2, Kiaa1985
Domain Architecture
Description	SH3 domain and tetratricopeptide repeats-containing protein 2.

LAMC1_HUMAN
NC score	0.031698 (rank : 181)	θ value	0.00509761 (rank : 24)
Query Neighborhood Hits	88	Target Neighborhood Hits	922	Shared Neighborhood Hits	12
SwissProt Accessions	P11047	Gene names	LAMC1, LAMB2
Domain Architecture
Description	Laminin gamma-1 chain precursor (Laminin B2 chain).

CE005_HUMAN
NC score	0.028546 (rank : 182)	θ value	1.81305 (rank : 64)
Query Neighborhood Hits	88	Target Neighborhood Hits	213	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NYF5, Q6PGQ2, Q9P0I7	Gene names	C5orf5
Domain Architecture
Description	Protein C5orf5 (GAP-like protein N61).

NTBP1_MOUSE
NC score	0.028013 (rank : 183)	θ value	4.03905 (rank : 76)
Query Neighborhood Hits	88	Target Neighborhood Hits	528	Shared Neighborhood Hits	14
SwissProt Accessions	Q8BRM2, Q8CAA8	Gene names	Scyl1bp1, Ntklbp1
Domain Architecture	No domain graphic available
Description	N-terminal kinase-like-binding protein 1 (NTKL-binding protein 1) (NTKL-BP1) (mNTKL-BP1) (SCY1-like 1-binding protein 1) (SCYL1-binding protein 1) (SCYL1-BP1).

LAMC1_MOUSE
NC score	0.023806 (rank : 184)	θ value	1.81305 (rank : 67)
Query Neighborhood Hits	88	Target Neighborhood Hits	856	Shared Neighborhood Hits	13
SwissProt Accessions	P02468	Gene names	Lamc1, Lamb-2, Lamc-1
Domain Architecture
Description	Laminin gamma-1 chain precursor (Laminin B2 chain).

GOGB1_HUMAN
NC score	0.023038 (rank : 185)	θ value	1.81305 (rank : 65)
Query Neighborhood Hits	88	Target Neighborhood Hits	2297	Shared Neighborhood Hits	30
SwissProt Accessions	Q14789, Q14398	Gene names	GOLGB1
Domain Architecture
Description	Golgin subfamily B member 1 (Giantin) (Macrogolgin) (372 kDa Golgi complex-associated protein) (GCP372).

ITK_HUMAN
NC score	0.018663 (rank : 186)	θ value	4.03905 (rank : 74)
Query Neighborhood Hits	88	Target Neighborhood Hits	1016	Shared Neighborhood Hits	48
SwissProt Accessions	Q08881	Gene names	ITK, EMT, LYK
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (Tyrosine-protein kinase Lyk) (Kinase EMT).

BBS2_HUMAN
NC score	0.018612 (rank : 187)	θ value	8.99809 (rank : 85)
Query Neighborhood Hits	88	Target Neighborhood Hits	18	Shared Neighborhood Hits	3
SwissProt Accessions	Q9BXC9, Q96CM0, Q96SN9	Gene names	BBS2
Domain Architecture	No domain graphic available
Description	Bardet-Biedl syndrome 2 protein.

ITK_MOUSE
NC score	0.016359 (rank : 188)	θ value	3.0926 (rank : 72)
Query Neighborhood Hits	88	Target Neighborhood Hits	985	Shared Neighborhood Hits	44
SwissProt Accessions	Q03526	Gene names	Itk, Emt, Tlk, Tsk
Domain Architecture
Description	Tyrosine-protein kinase ITK/TSK (EC 2.7.10.2) (T-cell-specific kinase) (IL-2-inducible T-cell kinase) (Kinase EMT) (Kinase TLK).

NFL_HUMAN
NC score	0.012512 (rank : 189)	θ value	1.38821 (rank : 63)
Query Neighborhood Hits	88	Target Neighborhood Hits	666	Shared Neighborhood Hits	13
SwissProt Accessions	P07196, Q16154, Q8IU72	Gene names	NEFL, NF68, NFL
Domain Architecture
Description	Neurofilament triplet L protein (68 kDa neurofilament protein) (Neurofilament light polypeptide) (NF-L).

NFL_MOUSE
NC score	0.011509 (rank : 190)	θ value	2.36792 (rank : 70)
Query Neighborhood Hits	88	Target Neighborhood Hits	695	Shared Neighborhood Hits	13
SwissProt Accessions	P08551, Q8K0Z0	Gene names	Nefl, Nf68, Nfl
Domain Architecture
Description	Neurofilament triplet L protein (68 kDa neurofilament protein) (Neurofilament light polypeptide) (NF-L).

MAP4_MOUSE
NC score	0.009650 (rank : 191)	θ value	5.27518 (rank : 79)
Query Neighborhood Hits	88	Target Neighborhood Hits	409	Shared Neighborhood Hits	5
SwissProt Accessions	P27546	Gene names	Map4, Mtap4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).