Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : SASH1_MOUSE

For an explanation of this page, click here

SASH1_MOUSE
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SASH1_HUMAN
θ value	0 (rank : 1)	NC score	0.951963 (rank : 2)
Query Neighborhood Hits	263	Target Neighborhood Hits	292	Shared Neighborhood Hits	138
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SASH1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	263	Target Neighborhood Hits	263	Shared Neighborhood Hits	263
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

SLY_MOUSE
θ value	1.55911e-60 (rank : 3)	NC score	0.833082 (rank : 4)
Query Neighborhood Hits	263	Target Neighborhood Hits	108	Shared Neighborhood Hits	62
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SLY_HUMAN
θ value	8.55514e-59 (rank : 4)	NC score	0.836015 (rank : 3)
Query Neighborhood Hits	263	Target Neighborhood Hits	81	Shared Neighborhood Hits	57
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SAMN1_HUMAN
θ value	3.48949e-44 (rank : 5)	NC score	0.816015 (rank : 5)
Query Neighborhood Hits	263	Target Neighborhood Hits	74	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

SAMN1_MOUSE
θ value	6.58091e-43 (rank : 6)	NC score	0.812510 (rank : 6)
Query Neighborhood Hits	263	Target Neighborhood Hits	69	Shared Neighborhood Hits	50
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

ANKS1_HUMAN
θ value	1.43324e-05 (rank : 7)	NC score	0.147775 (rank : 16)
Query Neighborhood Hits	263	Target Neighborhood Hits	438	Shared Neighborhood Hits	50
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

ANKS1_MOUSE
θ value	0.00020696 (rank : 8)	NC score	0.150638 (rank : 15)
Query Neighborhood Hits	263	Target Neighborhood Hits	453	Shared Neighborhood Hits	51
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

PRG4_HUMAN
θ value	0.00035302 (rank : 9)	NC score	0.104977 (rank : 34)
Query Neighborhood Hits	263	Target Neighborhood Hits	764	Shared Neighborhood Hits	57
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

CD2AP_HUMAN
θ value	0.000461057 (rank : 10)	NC score	0.207151 (rank : 7)
Query Neighborhood Hits	263	Target Neighborhood Hits	315	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

EPHB6_MOUSE
θ value	0.00102713 (rank : 11)	NC score	0.101717 (rank : 38)
Query Neighborhood Hits	263	Target Neighborhood Hits	906	Shared Neighborhood Hits	55
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

CSKI1_HUMAN
θ value	0.00134147 (rank : 12)	NC score	0.136008 (rank : 21)
Query Neighborhood Hits	263	Target Neighborhood Hits	997	Shared Neighborhood Hits	120
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI1_MOUSE
θ value	0.00134147 (rank : 13)	NC score	0.136758 (rank : 20)
Query Neighborhood Hits	263	Target Neighborhood Hits	1031	Shared Neighborhood Hits	122
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

MYO1E_HUMAN
θ value	0.00134147 (rank : 14)	NC score	0.084064 (rank : 70)
Query Neighborhood Hits	263	Target Neighborhood Hits	293	Shared Neighborhood Hits	60
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

GRAP_HUMAN
θ value	0.00298849 (rank : 15)	NC score	0.141434 (rank : 17)
Query Neighborhood Hits	263	Target Neighborhood Hits	307	Shared Neighborhood Hits	60
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

MAST3_HUMAN
θ value	0.00298849 (rank : 16)	NC score	0.025963 (rank : 304)
Query Neighborhood Hits	263	Target Neighborhood Hits	1128	Shared Neighborhood Hits	64
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

SET1A_HUMAN
θ value	0.00298849 (rank : 17)	NC score	0.082577 (rank : 74)
Query Neighborhood Hits	263	Target Neighborhood Hits	690	Shared Neighborhood Hits	54
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

EPHA4_MOUSE
θ value	0.00390308 (rank : 18)	NC score	0.087486 (rank : 60)
Query Neighborhood Hits	263	Target Neighborhood Hits	982	Shared Neighborhood Hits	52
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

PRG4_MOUSE
θ value	0.00390308 (rank : 19)	NC score	0.095824 (rank : 47)
Query Neighborhood Hits	263	Target Neighborhood Hits	624	Shared Neighborhood Hits	57
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

EPHA5_HUMAN
θ value	0.00509761 (rank : 20)	NC score	0.085366 (rank : 63)
Query Neighborhood Hits	263	Target Neighborhood Hits	1009	Shared Neighborhood Hits	54
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

CSKI2_HUMAN
θ value	0.00869519 (rank : 21)	NC score	0.124195 (rank : 26)
Query Neighborhood Hits	263	Target Neighborhood Hits	747	Shared Neighborhood Hits	96
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

CSKI2_MOUSE
θ value	0.00869519 (rank : 22)	NC score	0.128168 (rank : 24)
Query Neighborhood Hits	263	Target Neighborhood Hits	812	Shared Neighborhood Hits	103
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

EPHA4_HUMAN
θ value	0.0113563 (rank : 23)	NC score	0.086547 (rank : 61)
Query Neighborhood Hits	263	Target Neighborhood Hits	975	Shared Neighborhood Hits	52
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

FMN2_HUMAN
θ value	0.0113563 (rank : 24)	NC score	0.064818 (rank : 133)
Query Neighborhood Hits	263	Target Neighborhood Hits	484	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

EPHA7_HUMAN
θ value	0.0148317 (rank : 25)	NC score	0.085168 (rank : 65)
Query Neighborhood Hits	263	Target Neighborhood Hits	1053	Shared Neighborhood Hits	53
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHB6_HUMAN
θ value	0.0148317 (rank : 26)	NC score	0.099385 (rank : 40)
Query Neighborhood Hits	263	Target Neighborhood Hits	912	Shared Neighborhood Hits	53
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

CRK_MOUSE
θ value	0.0193708 (rank : 27)	NC score	0.178001 (rank : 9)
Query Neighborhood Hits	263	Target Neighborhood Hits	314	Shared Neighborhood Hits	60
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SRRM2_HUMAN
θ value	0.0193708 (rank : 28)	NC score	0.093333 (rank : 49)
Query Neighborhood Hits	263	Target Neighborhood Hits	1296	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

CRK_HUMAN
θ value	0.0252991 (rank : 29)	NC score	0.172999 (rank : 11)
Query Neighborhood Hits	263	Target Neighborhood Hits	308	Shared Neighborhood Hits	61
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

EPHA7_MOUSE
θ value	0.0252991 (rank : 30)	NC score	0.084740 (rank : 66)
Query Neighborhood Hits	263	Target Neighborhood Hits	1025	Shared Neighborhood Hits	53
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

MUC1_HUMAN
θ value	0.0252991 (rank : 31)	NC score	0.075234 (rank : 104)
Query Neighborhood Hits	263	Target Neighborhood Hits	975	Shared Neighborhood Hits	69
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

EPHA6_MOUSE
θ value	0.0330416 (rank : 32)	NC score	0.089739 (rank : 56)
Query Neighborhood Hits	263	Target Neighborhood Hits	946	Shared Neighborhood Hits	54
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

MAP1B_HUMAN
θ value	0.0330416 (rank : 33)	NC score	0.070630 (rank : 114)
Query Neighborhood Hits	263	Target Neighborhood Hits	903	Shared Neighborhood Hits	57
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

GFAP_HUMAN
θ value	0.0431538 (rank : 34)	NC score	0.024219 (rank : 312)
Query Neighborhood Hits	263	Target Neighborhood Hits	723	Shared Neighborhood Hits	20
SwissProt Accessions	P14136, Q53H98, Q5D055, Q6ZQS3, Q7Z5J6, Q7Z5J7, Q96KS4, Q96P18, Q9UFD0	Gene names	GFAP
Domain Architecture
Description	Glial fibrillary acidic protein, astrocyte (GFAP).

MYST3_MOUSE
θ value	0.0431538 (rank : 35)	NC score	0.037986 (rank : 261)
Query Neighborhood Hits	263	Target Neighborhood Hits	688	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

SFR15_HUMAN
θ value	0.0431538 (rank : 36)	NC score	0.074717 (rank : 105)
Query Neighborhood Hits	263	Target Neighborhood Hits	368	Shared Neighborhood Hits	31
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

SRRM2_MOUSE
θ value	0.0431538 (rank : 37)	NC score	0.099063 (rank : 42)
Query Neighborhood Hits	263	Target Neighborhood Hits	1470	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

ARHG7_MOUSE
θ value	0.0563607 (rank : 38)	NC score	0.134986 (rank : 22)
Query Neighborhood Hits	263	Target Neighborhood Hits	396	Shared Neighborhood Hits	60
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ITSN1_HUMAN
θ value	0.0563607 (rank : 39)	NC score	0.097065 (rank : 45)
Query Neighborhood Hits	263	Target Neighborhood Hits	1757	Shared Neighborhood Hits	113
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

LRC56_HUMAN
θ value	0.0563607 (rank : 40)	NC score	0.057775 (rank : 177)
Query Neighborhood Hits	263	Target Neighborhood Hits	165	Shared Neighborhood Hits	12
SwissProt Accessions	Q8IYG6, Q8N3Q4	Gene names	LRRC56
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 56.

NACAM_MOUSE
θ value	0.0563607 (rank : 41)	NC score	0.100076 (rank : 39)
Query Neighborhood Hits	263	Target Neighborhood Hits	1866	Shared Neighborhood Hits	110
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

RIN3_HUMAN
θ value	0.0563607 (rank : 42)	NC score	0.070542 (rank : 115)
Query Neighborhood Hits	263	Target Neighborhood Hits	227	Shared Neighborhood Hits	31
SwissProt Accessions	Q8TB24, Q8NF30, Q8TEE8, Q8WYP4, Q9H6A5, Q9HAG1	Gene names	RIN3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

ARHG7_HUMAN
θ value	0.0736092 (rank : 43)	NC score	0.138125 (rank : 19)
Query Neighborhood Hits	263	Target Neighborhood Hits	347	Shared Neighborhood Hits	58
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

CEND1_HUMAN
θ value	0.0736092 (rank : 44)	NC score	0.077073 (rank : 101)
Query Neighborhood Hits	263	Target Neighborhood Hits	284	Shared Neighborhood Hits	43
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

CRKL_HUMAN
θ value	0.0736092 (rank : 45)	NC score	0.164856 (rank : 13)
Query Neighborhood Hits	263	Target Neighborhood Hits	313	Shared Neighborhood Hits	59
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CRKL_MOUSE
θ value	0.0736092 (rank : 46)	NC score	0.164945 (rank : 12)
Query Neighborhood Hits	263	Target Neighborhood Hits	307	Shared Neighborhood Hits	60
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

SH3K1_HUMAN
θ value	0.0736092 (rank : 47)	NC score	0.179441 (rank : 8)
Query Neighborhood Hits	263	Target Neighborhood Hits	341	Shared Neighborhood Hits	69
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

EPHB1_HUMAN
θ value	0.0961366 (rank : 48)	NC score	0.081935 (rank : 78)
Query Neighborhood Hits	263	Target Neighborhood Hits	988	Shared Neighborhood Hits	53
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

NAF1_HUMAN
θ value	0.0961366 (rank : 49)	NC score	0.031958 (rank : 278)
Query Neighborhood Hits	263	Target Neighborhood Hits	937	Shared Neighborhood Hits	39
SwissProt Accessions	Q15025, O76008, Q96EL9, Q99833, Q9H1J3	Gene names	TNIP1, KIAA0113, NAF1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (HIV-1 Nef-interacting protein) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) (Nip40-1).

VAV_HUMAN
θ value	0.0961366 (rank : 50)	NC score	0.117235 (rank : 29)
Query Neighborhood Hits	263	Target Neighborhood Hits	452	Shared Neighborhood Hits	58
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

ARHG6_HUMAN
θ value	0.125558 (rank : 51)	NC score	0.140785 (rank : 18)
Query Neighborhood Hits	263	Target Neighborhood Hits	376	Shared Neighborhood Hits	58
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

EPHA6_HUMAN
θ value	0.125558 (rank : 52)	NC score	0.089109 (rank : 58)
Query Neighborhood Hits	263	Target Neighborhood Hits	959	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

TRDN_HUMAN
θ value	0.125558 (rank : 53)	NC score	0.079711 (rank : 91)
Query Neighborhood Hits	263	Target Neighborhood Hits	542	Shared Neighborhood Hits	37
SwissProt Accessions	Q13061	Gene names	TRDN
Domain Architecture
Description	Triadin.

VAV_MOUSE
θ value	0.125558 (rank : 54)	NC score	0.117626 (rank : 28)
Query Neighborhood Hits	263	Target Neighborhood Hits	430	Shared Neighborhood Hits	60
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

ANK2_HUMAN
θ value	0.163984 (rank : 55)	NC score	0.056827 (rank : 183)
Query Neighborhood Hits	263	Target Neighborhood Hits	1615	Shared Neighborhood Hits	102
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

EPHB4_MOUSE
θ value	0.163984 (rank : 56)	NC score	0.081046 (rank : 83)
Query Neighborhood Hits	263	Target Neighborhood Hits	1013	Shared Neighborhood Hits	53
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

PINX1_HUMAN
θ value	0.163984 (rank : 57)	NC score	0.052026 (rank : 210)
Query Neighborhood Hits	263	Target Neighborhood Hits	65	Shared Neighborhood Hits	5
SwissProt Accessions	Q96BK5, Q7Z7J8, Q96QD7, Q9HBU7, Q9NWW2	Gene names	PINX1, LPTS
Domain Architecture
Description	Pin2-interacting protein X1 (TRF1-interacting protein 1) (Liver- related putative tumor suppressor) (67-11-3 protein).

SH3K1_MOUSE
θ value	0.163984 (rank : 58)	NC score	0.174349 (rank : 10)
Query Neighborhood Hits	263	Target Neighborhood Hits	332	Shared Neighborhood Hits	67
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

SON_HUMAN
θ value	0.163984 (rank : 59)	NC score	0.078462 (rank : 96)
Query Neighborhood Hits	263	Target Neighborhood Hits	1568	Shared Neighborhood Hits	93
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

GRAP_MOUSE
θ value	0.21417 (rank : 60)	NC score	0.125990 (rank : 25)
Query Neighborhood Hits	263	Target Neighborhood Hits	309	Shared Neighborhood Hits	60
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

GSCR1_HUMAN
θ value	0.21417 (rank : 61)	NC score	0.085248 (rank : 64)
Query Neighborhood Hits	263	Target Neighborhood Hits	674	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

M3K9_HUMAN
θ value	0.21417 (rank : 62)	NC score	0.064173 (rank : 136)
Query Neighborhood Hits	263	Target Neighborhood Hits	1123	Shared Neighborhood Hits	101
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

BRD4_HUMAN
θ value	0.279714 (rank : 63)	NC score	0.046738 (rank : 247)
Query Neighborhood Hits	263	Target Neighborhood Hits	851	Shared Neighborhood Hits	57
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

CEND1_MOUSE
θ value	0.279714 (rank : 64)	NC score	0.062572 (rank : 146)
Query Neighborhood Hits	263	Target Neighborhood Hits	260	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

EPHA1_MOUSE
θ value	0.279714 (rank : 65)	NC score	0.081852 (rank : 79)
Query Neighborhood Hits	263	Target Neighborhood Hits	958	Shared Neighborhood Hits	53
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

EPHA5_MOUSE
θ value	0.279714 (rank : 66)	NC score	0.071945 (rank : 112)
Query Neighborhood Hits	263	Target Neighborhood Hits	950	Shared Neighborhood Hits	52
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

EPHB4_HUMAN
θ value	0.279714 (rank : 67)	NC score	0.080106 (rank : 87)
Query Neighborhood Hits	263	Target Neighborhood Hits	1056	Shared Neighborhood Hits	53
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

NCK2_HUMAN
θ value	0.365318 (rank : 68)	NC score	0.118674 (rank : 27)
Query Neighborhood Hits	263	Target Neighborhood Hits	310	Shared Neighborhood Hits	57
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

NFH_MOUSE
θ value	0.365318 (rank : 69)	NC score	0.066393 (rank : 126)
Query Neighborhood Hits	263	Target Neighborhood Hits	2247	Shared Neighborhood Hits	127
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

WNK4_HUMAN
θ value	0.365318 (rank : 70)	NC score	0.032259 (rank : 277)
Query Neighborhood Hits	263	Target Neighborhood Hits	1043	Shared Neighborhood Hits	70
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

BRE1A_HUMAN
θ value	0.47712 (rank : 71)	NC score	0.017461 (rank : 340)
Query Neighborhood Hits	263	Target Neighborhood Hits	1071	Shared Neighborhood Hits	33
SwissProt Accessions	Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83	Gene names	RNF20, BRE1A
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (hBRE1) (RING finger protein 20).

FA47B_HUMAN
θ value	0.47712 (rank : 72)	NC score	0.072753 (rank : 108)
Query Neighborhood Hits	263	Target Neighborhood Hits	431	Shared Neighborhood Hits	53
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

MINT_MOUSE
θ value	0.47712 (rank : 73)	NC score	0.058993 (rank : 172)
Query Neighborhood Hits	263	Target Neighborhood Hits	1514	Shared Neighborhood Hits	91
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

NMT2_HUMAN
θ value	0.47712 (rank : 74)	NC score	0.027799 (rank : 299)
Query Neighborhood Hits	263	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	O60551, Q53Y38, Q5VUC8, Q9BRB4	Gene names	NMT2
Domain Architecture
Description	Glycylpeptide N-tetradecanoyltransferase 2 (EC 2.3.1.97) (Peptide N- myristoyltransferase 2) (Myristoyl-CoA:protein N-myristoyltransferase 2) (NMT 2) (Type II N-myristoyltransferase).

PCLO_HUMAN
θ value	0.47712 (rank : 75)	NC score	0.072418 (rank : 110)
Query Neighborhood Hits	263	Target Neighborhood Hits	2046	Shared Neighborhood Hits	122
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

RIN3_MOUSE
θ value	0.47712 (rank : 76)	NC score	0.061866 (rank : 153)
Query Neighborhood Hits	263	Target Neighborhood Hits	239	Shared Neighborhood Hits	32
SwissProt Accessions	P59729	Gene names	Rin3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

ZCPW1_HUMAN
θ value	0.47712 (rank : 77)	NC score	0.042385 (rank : 252)
Query Neighborhood Hits	263	Target Neighborhood Hits	116	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H0M4, Q8NA98, Q9BUD0, Q9NWF7	Gene names	ZCWPW1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1.

ARHG6_MOUSE
θ value	0.62314 (rank : 78)	NC score	0.134366 (rank : 23)
Query Neighborhood Hits	263	Target Neighborhood Hits	394	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

BSN_MOUSE
θ value	0.62314 (rank : 79)	NC score	0.072520 (rank : 109)
Query Neighborhood Hits	263	Target Neighborhood Hits	2057	Shared Neighborhood Hits	109
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

EPHA1_HUMAN
θ value	0.62314 (rank : 80)	NC score	0.079846 (rank : 90)
Query Neighborhood Hits	263	Target Neighborhood Hits	997	Shared Neighborhood Hits	52
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

GFAP_MOUSE
θ value	0.62314 (rank : 81)	NC score	0.020889 (rank : 326)
Query Neighborhood Hits	263	Target Neighborhood Hits	725	Shared Neighborhood Hits	22
SwissProt Accessions	P03995, Q7TQ30, Q925K3	Gene names	Gfap
Domain Architecture
Description	Glial fibrillary acidic protein, astrocyte (GFAP).

MDC1_HUMAN
θ value	0.62314 (rank : 82)	NC score	0.089983 (rank : 55)
Query Neighborhood Hits	263	Target Neighborhood Hits	1446	Shared Neighborhood Hits	106
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

MYO1F_HUMAN
θ value	0.62314 (rank : 83)	NC score	0.065948 (rank : 127)
Query Neighborhood Hits	263	Target Neighborhood Hits	275	Shared Neighborhood Hits	64
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

MYPN_HUMAN
θ value	0.62314 (rank : 84)	NC score	0.021158 (rank : 325)
Query Neighborhood Hits	263	Target Neighborhood Hits	418	Shared Neighborhood Hits	24
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

PRR12_HUMAN
θ value	0.62314 (rank : 85)	NC score	0.081641 (rank : 80)
Query Neighborhood Hits	263	Target Neighborhood Hits	460	Shared Neighborhood Hits	50
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

RGS3_MOUSE
θ value	0.62314 (rank : 86)	NC score	0.061119 (rank : 159)
Query Neighborhood Hits	263	Target Neighborhood Hits	1621	Shared Neighborhood Hits	97
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

ITSN1_MOUSE
θ value	0.813845 (rank : 87)	NC score	0.088097 (rank : 59)
Query Neighborhood Hits	263	Target Neighborhood Hits	1669	Shared Neighborhood Hits	112
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

IWS1_MOUSE
θ value	0.813845 (rank : 88)	NC score	0.061602 (rank : 156)
Query Neighborhood Hits	263	Target Neighborhood Hits	1258	Shared Neighborhood Hits	85
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

JHD2A_HUMAN
θ value	0.813845 (rank : 89)	NC score	0.034985 (rank : 270)
Query Neighborhood Hits	263	Target Neighborhood Hits	118	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y4C1, Q53S72, Q68D47, Q68UT9, Q6N050, Q8IY08	Gene names	JMJD1A, JHDM2A, JMJD1, KIAA0742
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2A (EC 1.14.11.-) (Jumonji domain-containing protein 1A).

K1543_HUMAN
θ value	0.813845 (rank : 90)	NC score	0.059729 (rank : 167)
Query Neighborhood Hits	263	Target Neighborhood Hits	435	Shared Neighborhood Hits	50
SwissProt Accessions	Q9P1Y5, Q8NDF1	Gene names	KIAA1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

M3K11_HUMAN
θ value	0.813845 (rank : 91)	NC score	0.058944 (rank : 173)
Query Neighborhood Hits	263	Target Neighborhood Hits	1136	Shared Neighborhood Hits	106
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

NOL1_HUMAN
θ value	0.813845 (rank : 92)	NC score	0.047749 (rank : 244)
Query Neighborhood Hits	263	Target Neighborhood Hits	74	Shared Neighborhood Hits	11
SwissProt Accessions	P46087	Gene names	NOL1
Domain Architecture
Description	Proliferating-cell nucleolar antigen p120 (Proliferation-associated nucleolar protein p120).

STAC_HUMAN
θ value	0.813845 (rank : 93)	NC score	0.115043 (rank : 30)
Query Neighborhood Hits	263	Target Neighborhood Hits	276	Shared Neighborhood Hits	62
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

ZBTB5_MOUSE
θ value	0.813845 (rank : 94)	NC score	0.004886 (rank : 364)
Query Neighborhood Hits	263	Target Neighborhood Hits	801	Shared Neighborhood Hits	9
SwissProt Accessions	Q7TQG0, Q3TVR7, Q6GV09, Q8BIB5	Gene names	Zbtb5, Kiaa0354
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 5 (Transcription factor ZNF-POZ).

BRPF1_HUMAN
θ value	1.06291 (rank : 95)	NC score	0.026123 (rank : 303)
Query Neighborhood Hits	263	Target Neighborhood Hits	259	Shared Neighborhood Hits	22
SwissProt Accessions	P55201, Q9UHI0	Gene names	BRPF1, BR140
Domain Architecture
Description	Peregrin (Bromodomain and PHD finger-containing protein 1) (BR140 protein).

CAC2D_MOUSE
θ value	1.06291 (rank : 96)	NC score	0.040463 (rank : 256)
Query Neighborhood Hits	263	Target Neighborhood Hits	42	Shared Neighborhood Hits	5
SwissProt Accessions	O08532, O08533, O08534, O08535, O08536	Gene names	Cacna2d1, Cacna2
Domain Architecture
Description	Dihydropyridine-sensitive L-type calcium channel subunits alpha- 2/delta precursor [Contains: L-type calcium channel subunit alpha-2; L-type calcium channel subunit delta].

CD2AP_MOUSE
θ value	1.06291 (rank : 97)	NC score	0.163571 (rank : 14)
Query Neighborhood Hits	263	Target Neighborhood Hits	336	Shared Neighborhood Hits	70
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

DDX50_MOUSE
θ value	1.06291 (rank : 98)	NC score	0.012285 (rank : 352)
Query Neighborhood Hits	263	Target Neighborhood Hits	137	Shared Neighborhood Hits	6
SwissProt Accessions	Q99MJ9	Gene names	Ddx50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

DGKK_HUMAN
θ value	1.06291 (rank : 99)	NC score	0.042936 (rank : 251)
Query Neighborhood Hits	263	Target Neighborhood Hits	378	Shared Neighborhood Hits	42
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

EF2K_MOUSE
θ value	1.06291 (rank : 100)	NC score	0.028212 (rank : 296)
Query Neighborhood Hits	263	Target Neighborhood Hits	33	Shared Neighborhood Hits	5
SwissProt Accessions	O08796	Gene names	Eef2k
Domain Architecture
Description	Elongation factor 2 kinase (EC 2.7.11.20) (eEF-2 kinase) (eEF-2K) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase).

EPHB3_HUMAN
θ value	1.06291 (rank : 101)	NC score	0.082383 (rank : 76)
Query Neighborhood Hits	263	Target Neighborhood Hits	996	Shared Neighborhood Hits	53
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

GRAP2_MOUSE
θ value	1.06291 (rank : 102)	NC score	0.103853 (rank : 35)
Query Neighborhood Hits	263	Target Neighborhood Hits	297	Shared Neighborhood Hits	57
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

ITSN2_MOUSE
θ value	1.06291 (rank : 103)	NC score	0.080605 (rank : 84)
Query Neighborhood Hits	263	Target Neighborhood Hits	1371	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

JADE2_MOUSE
θ value	1.06291 (rank : 104)	NC score	0.046349 (rank : 248)
Query Neighborhood Hits	263	Target Neighborhood Hits	560	Shared Neighborhood Hits	52
SwissProt Accessions	Q6ZQF7, Q3UHD5, Q6IE83	Gene names	Phf15, Jade2, Kiaa0239
Domain Architecture	No domain graphic available
Description	Protein Jade-2 (PHD finger protein 15).

LCP2_MOUSE
θ value	1.06291 (rank : 105)	NC score	0.052797 (rank : 204)
Query Neighborhood Hits	263	Target Neighborhood Hits	177	Shared Neighborhood Hits	30
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

OGFR_HUMAN
θ value	1.06291 (rank : 106)	NC score	0.075608 (rank : 103)
Query Neighborhood Hits	263	Target Neighborhood Hits	1582	Shared Neighborhood Hits	95
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

RN168_MOUSE
θ value	1.06291 (rank : 107)	NC score	0.023995 (rank : 313)
Query Neighborhood Hits	263	Target Neighborhood Hits	440	Shared Neighborhood Hits	13
SwissProt Accessions	Q80XJ2	Gene names	Rnf168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

ROBO3_MOUSE
θ value	1.06291 (rank : 108)	NC score	0.022783 (rank : 321)
Query Neighborhood Hits	263	Target Neighborhood Hits	524	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

VAV3_HUMAN
θ value	1.06291 (rank : 109)	NC score	0.102408 (rank : 37)
Query Neighborhood Hits	263	Target Neighborhood Hits	398	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

CDSN_MOUSE
θ value	1.38821 (rank : 110)	NC score	0.033171 (rank : 274)
Query Neighborhood Hits	263	Target Neighborhood Hits	131	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TPC1	Gene names	Cdsn
Domain Architecture	No domain graphic available
Description	Corneodesmosin precursor.

DDFL1_HUMAN
θ value	1.38821 (rank : 111)	NC score	0.034734 (rank : 271)
Query Neighborhood Hits	263	Target Neighborhood Hits	353	Shared Neighborhood Hits	22
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

DHX37_HUMAN
θ value	1.38821 (rank : 112)	NC score	0.018250 (rank : 334)
Query Neighborhood Hits	263	Target Neighborhood Hits	133	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IY37, Q9BUI7, Q9P211	Gene names	DHX37, DDX37, KIAA1517
Domain Architecture
Description	Probable ATP-dependent RNA helicase DHX37 (EC 3.6.1.-) (DEAH box protein 37).

ETV3_HUMAN
θ value	1.38821 (rank : 113)	NC score	0.028485 (rank : 294)
Query Neighborhood Hits	263	Target Neighborhood Hits	312	Shared Neighborhood Hits	36
SwissProt Accessions	P41162, Q8TAC8, Q9BX30	Gene names	ETV3, METS, PE1
Domain Architecture	No domain graphic available
Description	ETS translocation variant 3 (ETS-domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor).

GON4L_MOUSE
θ value	1.38821 (rank : 114)	NC score	0.038342 (rank : 260)
Query Neighborhood Hits	263	Target Neighborhood Hits	455	Shared Neighborhood Hits	43
SwissProt Accessions	Q9DB00, Q80TB4, Q91YI9	Gene names	Gon4l, Gon4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

IF2P_HUMAN
θ value	1.38821 (rank : 115)	NC score	0.047800 (rank : 243)
Query Neighborhood Hits	263	Target Neighborhood Hits	889	Shared Neighborhood Hits	39
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

JPH1_MOUSE
θ value	1.38821 (rank : 116)	NC score	0.027928 (rank : 298)
Query Neighborhood Hits	263	Target Neighborhood Hits	120	Shared Neighborhood Hits	18
SwissProt Accessions	Q9ET80, Q9EQZ3	Gene names	Jph1, Jp1
Domain Architecture
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

MKL1_MOUSE
θ value	1.38821 (rank : 117)	NC score	0.042040 (rank : 253)
Query Neighborhood Hits	263	Target Neighborhood Hits	667	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

STAC_MOUSE
θ value	1.38821 (rank : 118)	NC score	0.111838 (rank : 31)
Query Neighborhood Hits	263	Target Neighborhood Hits	268	Shared Neighborhood Hits	59
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

THAP7_MOUSE
θ value	1.38821 (rank : 119)	NC score	0.033505 (rank : 273)
Query Neighborhood Hits	263	Target Neighborhood Hits	64	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VCZ3	Gene names	Thap7
Domain Architecture
Description	THAP domain-containing protein 7.

BAIP2_HUMAN
θ value	1.81305 (rank : 120)	NC score	0.036545 (rank : 267)
Query Neighborhood Hits	263	Target Neighborhood Hits	192	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

CTGE5_HUMAN
θ value	1.81305 (rank : 121)	NC score	0.013961 (rank : 348)
Query Neighborhood Hits	263	Target Neighborhood Hits	800	Shared Neighborhood Hits	31
SwissProt Accessions	O15320, O00169, Q6P2R8, Q8IX92, Q8IX93	Gene names	CTAGE5, MEA11, MEA6, MGEA11, MGEA6
Domain Architecture
Description	Cutaneous T-cell lymphoma-associated antigen 5 (cTAGE-5 protein) (cTAGE family member 5) (Meningioma-expressed antigen 6/11).

EPHA2_MOUSE
θ value	1.81305 (rank : 122)	NC score	0.080351 (rank : 85)
Query Neighborhood Hits	263	Target Neighborhood Hits	1020	Shared Neighborhood Hits	56
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

EPHB2_HUMAN
θ value	1.81305 (rank : 123)	NC score	0.079994 (rank : 89)
Query Neighborhood Hits	263	Target Neighborhood Hits	983	Shared Neighborhood Hits	53
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHB2_MOUSE
θ value	1.81305 (rank : 124)	NC score	0.079548 (rank : 92)
Query Neighborhood Hits	263	Target Neighborhood Hits	982	Shared Neighborhood Hits	53
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

FYB_HUMAN
θ value	1.81305 (rank : 125)	NC score	0.061067 (rank : 160)
Query Neighborhood Hits	263	Target Neighborhood Hits	379	Shared Neighborhood Hits	55
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

GT2D1_MOUSE
θ value	1.81305 (rank : 126)	NC score	0.020808 (rank : 327)
Query Neighborhood Hits	263	Target Neighborhood Hits	36	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JI57, Q8VHD5, Q8VI58, Q9EQE7, Q9ESZ6, Q9ESZ7	Gene names	Gtf2ird1, Ben
Domain Architecture
Description	General transcription factor II-I repeat domain-containing protein 1 (GTF2I repeat domain-containing protein 1) (Binding factor for early enhancer).

MAST4_HUMAN
θ value	1.81305 (rank : 127)	NC score	0.036676 (rank : 265)
Query Neighborhood Hits	263	Target Neighborhood Hits	1804	Shared Neighborhood Hits	112
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

MBD6_HUMAN
θ value	1.81305 (rank : 128)	NC score	0.065006 (rank : 131)
Query Neighborhood Hits	263	Target Neighborhood Hits	349	Shared Neighborhood Hits	40
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

NCOA7_HUMAN
θ value	1.81305 (rank : 129)	NC score	0.022614 (rank : 322)
Query Neighborhood Hits	263	Target Neighborhood Hits	160	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NI08, Q3LID6, Q4G0V1, Q5TF95, Q6IPQ4, Q6NE83, Q86T89, Q8N1W4	Gene names	NCOA7, ERAP140, ESNA1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1).

SYK_HUMAN
θ value	1.81305 (rank : 130)	NC score	0.027978 (rank : 297)
Query Neighborhood Hits	263	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q15046, O14946, Q96J25	Gene names	KARS, KIAA0070
Domain Architecture
Description	Lysyl-tRNA synthetase (EC 6.1.1.6) (Lysine--tRNA ligase) (LysRS).

VAV3_MOUSE
θ value	1.81305 (rank : 131)	NC score	0.099211 (rank : 41)
Query Neighborhood Hits	263	Target Neighborhood Hits	404	Shared Neighborhood Hits	55
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

ZN473_MOUSE
θ value	1.81305 (rank : 132)	NC score	-0.001396 (rank : 370)
Query Neighborhood Hits	263	Target Neighborhood Hits	824	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BI67, Q8BI98, Q8BIB7	Gene names	Znf473, Zfp100, Zfp473
Domain Architecture	No domain graphic available
Description	Zinc finger protein 473 homolog (Zinc finger protein 100) (Zfp-100).

AATK_HUMAN
θ value	2.36792 (rank : 133)	NC score	0.047060 (rank : 245)
Query Neighborhood Hits	263	Target Neighborhood Hits	1243	Shared Neighborhood Hits	83
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

AL2S4_MOUSE
θ value	2.36792 (rank : 134)	NC score	0.067413 (rank : 121)
Query Neighborhood Hits	263	Target Neighborhood Hits	193	Shared Neighborhood Hits	31
SwissProt Accessions	Q3V0J1, Q3TIS2	Gene names	Als2cr4
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog.

BORG5_HUMAN
θ value	2.36792 (rank : 135)	NC score	0.039892 (rank : 257)
Query Neighborhood Hits	263	Target Neighborhood Hits	135	Shared Neighborhood Hits	18
SwissProt Accessions	Q00587, Q96GN1	Gene names	CDC42EP1, BORG5, CEP1, MSE55
Domain Architecture
Description	Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55).

BRD4_MOUSE
θ value	2.36792 (rank : 136)	NC score	0.043542 (rank : 250)
Query Neighborhood Hits	263	Target Neighborhood Hits	845	Shared Neighborhood Hits	60
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

CD68_MOUSE
θ value	2.36792 (rank : 137)	NC score	0.027590 (rank : 300)
Query Neighborhood Hits	263	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	P31996	Gene names	Cd68
Domain Architecture
Description	Macrosialin precursor (CD68 antigen).

CLCN2_MOUSE
θ value	2.36792 (rank : 138)	NC score	0.019868 (rank : 329)
Query Neighborhood Hits	263	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	Q9R0A1, Q9WUJ9	Gene names	Clcn2, Clc2
Domain Architecture
Description	Chloride channel protein 2 (ClC-2).

EPHB3_MOUSE
θ value	2.36792 (rank : 139)	NC score	0.080032 (rank : 88)
Query Neighborhood Hits	263	Target Neighborhood Hits	996	Shared Neighborhood Hits	53
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

GRAP2_HUMAN
θ value	2.36792 (rank : 140)	NC score	0.096310 (rank : 46)
Query Neighborhood Hits	263	Target Neighborhood Hits	304	Shared Neighborhood Hits	58
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

IQGA2_HUMAN
θ value	2.36792 (rank : 141)	NC score	0.018659 (rank : 333)
Query Neighborhood Hits	263	Target Neighborhood Hits	200	Shared Neighborhood Hits	6
SwissProt Accessions	Q13576	Gene names	IQGAP2
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP2.

IRX5_HUMAN
θ value	2.36792 (rank : 142)	NC score	0.017928 (rank : 336)
Query Neighborhood Hits	263	Target Neighborhood Hits	362	Shared Neighborhood Hits	19
SwissProt Accessions	P78411, P78416, Q7Z2E1	Gene names	IRX5, IRX2A, IRXB2
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-5 (Iroquois homeobox protein 5) (Homeodomain protein IRXB2) (IRX-2A).

ITSN2_HUMAN
θ value	2.36792 (rank : 143)	NC score	0.081415 (rank : 82)
Query Neighborhood Hits	263	Target Neighborhood Hits	1173	Shared Neighborhood Hits	80
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

JHD2A_MOUSE
θ value	2.36792 (rank : 144)	NC score	0.038655 (rank : 258)
Query Neighborhood Hits	263	Target Neighborhood Hits	123	Shared Neighborhood Hits	21
SwissProt Accessions	Q6PCM1, Q2MJQ6, Q3TKW8, Q3UML3, Q6ZQ57, Q8K2J6, Q8K2K4, Q8R350	Gene names	Jmjd1a, Jhdm2a, Kiaa0742
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2A (EC 1.14.11.-) (Jumonji domain-containing protein 1A).

NEO1_MOUSE
θ value	2.36792 (rank : 145)	NC score	0.031221 (rank : 281)
Query Neighborhood Hits	263	Target Neighborhood Hits	523	Shared Neighborhood Hits	36
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

NPHP1_MOUSE
θ value	2.36792 (rank : 146)	NC score	0.084264 (rank : 69)
Query Neighborhood Hits	263	Target Neighborhood Hits	267	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

PCX1_HUMAN
θ value	2.36792 (rank : 147)	NC score	0.023147 (rank : 317)
Query Neighborhood Hits	263	Target Neighborhood Hits	102	Shared Neighborhood Hits	8
SwissProt Accessions	Q96RV3, O94897, Q96AI7, Q9Y2J9	Gene names	PCNX, KIAA0805, KIAA0995, PCNXL1
Domain Architecture
Description	Pecanex-like protein 1 (Pecanex homolog).

PDZD2_HUMAN
θ value	2.36792 (rank : 148)	NC score	0.047886 (rank : 242)
Query Neighborhood Hits	263	Target Neighborhood Hits	772	Shared Neighborhood Hits	66
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

PHLB1_MOUSE
θ value	2.36792 (rank : 149)	NC score	0.025343 (rank : 306)
Query Neighborhood Hits	263	Target Neighborhood Hits	678	Shared Neighborhood Hits	41
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

RAI1_HUMAN
θ value	2.36792 (rank : 150)	NC score	0.041052 (rank : 254)
Query Neighborhood Hits	263	Target Neighborhood Hits	360	Shared Neighborhood Hits	40
SwissProt Accessions	Q7Z5J4, Q8N3B4, Q8ND08, Q8WU64, Q96JK5, Q9H1C1, Q9H1C2, Q9UF69	Gene names	RAI1, KIAA1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

SH3G3_MOUSE
θ value	2.36792 (rank : 151)	NC score	0.102926 (rank : 36)
Query Neighborhood Hits	263	Target Neighborhood Hits	236	Shared Neighborhood Hits	56
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

SPTA3_MOUSE
θ value	2.36792 (rank : 152)	NC score	0.057271 (rank : 180)
Query Neighborhood Hits	263	Target Neighborhood Hits	74	Shared Neighborhood Hits	15
SwissProt Accessions	Q9D9T6, Q80ZS4, Q9D5L5, Q9DAF5	Gene names	Spata3, Tsarg1
Domain Architecture	No domain graphic available
Description	Spermatogenesis-associated protein 3 (Testis spermatocyte apoptosis- related protein 1) (Testis and spermatogenesis cell-related protein 1) (mTSARG1).

SSRP1_HUMAN
θ value	2.36792 (rank : 153)	NC score	0.022949 (rank : 319)
Query Neighborhood Hits	263	Target Neighborhood Hits	187	Shared Neighborhood Hits	8
SwissProt Accessions	Q08945, Q5BJG8	Gene names	SSRP1, FACT80
Domain Architecture
Description	FACT complex subunit SSRP1 (Facilitates chromatin transcription complex subunit SSRP1) (FACT 80 kDa subunit) (FACTp80) (Chromatin- specific transcription elongation factor 80 kDa subunit) (Structure- specific recognition protein 1) (hSSRP1) (Recombination signal sequence recognition protein 1) (T160).

TITIN_HUMAN
θ value	2.36792 (rank : 154)	NC score	0.029928 (rank : 288)
Query Neighborhood Hits	263	Target Neighborhood Hits	2923	Shared Neighborhood Hits	114
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

VAV2_MOUSE
θ value	2.36792 (rank : 155)	NC score	0.091338 (rank : 51)
Query Neighborhood Hits	263	Target Neighborhood Hits	456	Shared Neighborhood Hits	56
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

APC_HUMAN
θ value	3.0926 (rank : 156)	NC score	0.040975 (rank : 255)
Query Neighborhood Hits	263	Target Neighborhood Hits	603	Shared Neighborhood Hits	49
SwissProt Accessions	P25054, Q15162, Q15163, Q93042	Gene names	APC, DP2.5
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC).

CAC2D_HUMAN
θ value	3.0926 (rank : 157)	NC score	0.031725 (rank : 279)
Query Neighborhood Hits	263	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	P54289	Gene names	CACNA2D1, CACNL2A, CCHL2A
Domain Architecture
Description	Dihydropyridine-sensitive L-type calcium channel subunits alpha- 2/delta precursor [Contains: L-type calcium channel subunit alpha-2; L-type calcium channel subunit delta].

CLSPN_MOUSE
θ value	3.0926 (rank : 158)	NC score	0.025233 (rank : 307)
Query Neighborhood Hits	263	Target Neighborhood Hits	292	Shared Neighborhood Hits	21
SwissProt Accessions	Q80YR7, Q69GM2	Gene names	Clspn
Domain Architecture	No domain graphic available
Description	Claspin.

DAF1_MOUSE
θ value	3.0926 (rank : 159)	NC score	0.017508 (rank : 338)
Query Neighborhood Hits	263	Target Neighborhood Hits	204	Shared Neighborhood Hits	19
SwissProt Accessions	Q61475, P97732, Q61397	Gene names	Cd55a, Daf1
Domain Architecture
Description	Complement decay-accelerating factor, GPI-anchored precursor (DAF-GPI) (CD55 antigen).

EPHA2_HUMAN
θ value	3.0926 (rank : 160)	NC score	0.079032 (rank : 94)
Query Neighborhood Hits	263	Target Neighborhood Hits	1021	Shared Neighborhood Hits	58
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

IWS1_HUMAN
θ value	3.0926 (rank : 161)	NC score	0.060969 (rank : 161)
Query Neighborhood Hits	263	Target Neighborhood Hits	1241	Shared Neighborhood Hits	81
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

JHD1B_MOUSE
θ value	3.0926 (rank : 162)	NC score	0.014009 (rank : 347)
Query Neighborhood Hits	263	Target Neighborhood Hits	214	Shared Neighborhood Hits	13
SwissProt Accessions	Q6P1G2, Q3V396, Q6PFD0, Q6ZPE8, Q9CSF7, Q9QZN6	Gene names	Fbxl10, Fbl10, Jhdm1b, Kiaa3014
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 1B (EC 1.14.11.-) (F-box/LRR-repeat protein 10) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10).

MARK3_HUMAN
θ value	3.0926 (rank : 163)	NC score	0.023866 (rank : 314)
Query Neighborhood Hits	263	Target Neighborhood Hits	893	Shared Neighborhood Hits	52
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

MAVS_HUMAN
θ value	3.0926 (rank : 164)	NC score	0.058116 (rank : 175)
Query Neighborhood Hits	263	Target Neighborhood Hits	271	Shared Neighborhood Hits	29
SwissProt Accessions	Q7Z434, Q3I0Y2, Q5T7I6, Q86VY7, Q9H1H3, Q9H4Y1, Q9H8D3, Q9ULE9	Gene names	MAVS, IPS1, KIAA1271, VISA
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif) (Putative NF-kappa-B- activating protein 031N).

NCF1_MOUSE
θ value	3.0926 (rank : 165)	NC score	0.089722 (rank : 57)
Query Neighborhood Hits	263	Target Neighborhood Hits	198	Shared Neighborhood Hits	49
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

NOP5_HUMAN
θ value	3.0926 (rank : 166)	NC score	0.022534 (rank : 324)
Query Neighborhood Hits	263	Target Neighborhood Hits	84	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y2X3, Q6PK08, Q9P036, Q9UFN3	Gene names	NOP5
Domain Architecture
Description	Nucleolar protein NOP5 (Nucleolar protein 5) (NOP58).

OTOF_MOUSE
θ value	3.0926 (rank : 167)	NC score	0.017705 (rank : 337)
Query Neighborhood Hits	263	Target Neighborhood Hits	196	Shared Neighborhood Hits	10
SwissProt Accessions	Q9ESF1, Q9ESF2	Gene names	Otof, Fer1l2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

PCLO_MOUSE
θ value	3.0926 (rank : 168)	NC score	0.064891 (rank : 132)
Query Neighborhood Hits	263	Target Neighborhood Hits	2275	Shared Neighborhood Hits	127
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

PHC2_HUMAN
θ value	3.0926 (rank : 169)	NC score	0.051807 (rank : 214)
Query Neighborhood Hits	263	Target Neighborhood Hits	388	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IXK0, Q5T0C1, Q6NUJ6, Q6ZQR1, Q8N306, Q8TAG8, Q96BL4, Q9Y4Y7	Gene names	PHC2, EDR2, PH2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2).

PRC1_MOUSE
θ value	3.0926 (rank : 170)	NC score	0.029090 (rank : 291)
Query Neighborhood Hits	263	Target Neighborhood Hits	382	Shared Neighborhood Hits	19
SwissProt Accessions	Q99K43, Q8CE25	Gene names	Prc1
Domain Architecture	No domain graphic available
Description	Protein regulator of cytokinesis 1.

RAI14_HUMAN
θ value	3.0926 (rank : 171)	NC score	0.028419 (rank : 295)
Query Neighborhood Hits	263	Target Neighborhood Hits	1367	Shared Neighborhood Hits	47
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

REXO1_HUMAN
θ value	3.0926 (rank : 172)	NC score	0.034046 (rank : 272)
Query Neighborhood Hits	263	Target Neighborhood Hits	242	Shared Neighborhood Hits	31
SwissProt Accessions	Q8N1G1, Q9ULT2	Gene names	REXO1, ELOABP1, KIAA1138, TCEB3BP1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1).

RTP3_MOUSE
θ value	3.0926 (rank : 173)	NC score	0.062222 (rank : 148)
Query Neighborhood Hits	263	Target Neighborhood Hits	374	Shared Neighborhood Hits	53
SwissProt Accessions	Q5QGU6, Q8VDC2	Gene names	Rtp3, Tmem7
Domain Architecture	No domain graphic available
Description	Receptor-transporting protein 3 (Transmembrane protein 7).

SC24C_HUMAN
θ value	3.0926 (rank : 174)	NC score	0.035912 (rank : 269)
Query Neighborhood Hits	263	Target Neighborhood Hits	662	Shared Neighborhood Hits	48
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

SMBP2_HUMAN
θ value	3.0926 (rank : 175)	NC score	0.016611 (rank : 342)
Query Neighborhood Hits	263	Target Neighborhood Hits	107	Shared Neighborhood Hits	10
SwissProt Accessions	P38935, Q00443, Q14177	Gene names	IGHMBP2, SMBP2, SMUBP2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Glial factor 1) (GF-1).

SUHW3_MOUSE
θ value	3.0926 (rank : 176)	NC score	0.003087 (rank : 366)
Query Neighborhood Hits	263	Target Neighborhood Hits	697	Shared Neighborhood Hits	10
SwissProt Accessions	Q6P3Y5, Q6ZPM2, Q8K145	Gene names	Suhw3, Kiaa1584
Domain Architecture	No domain graphic available
Description	Suppressor of hairy wing homolog 3.

VAV2_HUMAN
θ value	3.0926 (rank : 177)	NC score	0.091363 (rank : 50)
Query Neighborhood Hits	263	Target Neighborhood Hits	453	Shared Neighborhood Hits	55
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

ANTR1_MOUSE
θ value	4.03905 (rank : 178)	NC score	0.030102 (rank : 287)
Query Neighborhood Hits	263	Target Neighborhood Hits	143	Shared Neighborhood Hits	26
SwissProt Accessions	Q9CZ52	Gene names	Antxr1, Atr, Tem8
Domain Architecture
Description	Anthrax toxin receptor 1 precursor (Tumor endothelial marker 8).

APBA1_HUMAN
θ value	4.03905 (rank : 179)	NC score	0.022551 (rank : 323)
Query Neighborhood Hits	263	Target Neighborhood Hits	325	Shared Neighborhood Hits	20
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

CECR2_HUMAN
θ value	4.03905 (rank : 180)	NC score	0.046752 (rank : 246)
Query Neighborhood Hits	263	Target Neighborhood Hits	543	Shared Neighborhood Hits	47
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

CEND3_HUMAN
θ value	4.03905 (rank : 181)	NC score	0.061965 (rank : 151)
Query Neighborhood Hits	263	Target Neighborhood Hits	275	Shared Neighborhood Hits	55
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

CSKP_HUMAN
θ value	4.03905 (rank : 182)	NC score	0.029110 (rank : 290)
Query Neighborhood Hits	263	Target Neighborhood Hits	1022	Shared Neighborhood Hits	79
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

CSKP_MOUSE
θ value	4.03905 (rank : 183)	NC score	0.028832 (rank : 292)
Query Neighborhood Hits	263	Target Neighborhood Hits	1027	Shared Neighborhood Hits	81
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

EPHA8_HUMAN
θ value	4.03905 (rank : 184)	NC score	0.078503 (rank : 95)
Query Neighborhood Hits	263	Target Neighborhood Hits	956	Shared Neighborhood Hits	52
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

EPHA8_MOUSE
θ value	4.03905 (rank : 185)	NC score	0.079528 (rank : 93)
Query Neighborhood Hits	263	Target Neighborhood Hits	969	Shared Neighborhood Hits	53
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHAA_HUMAN
θ value	4.03905 (rank : 186)	NC score	0.084723 (rank : 67)
Query Neighborhood Hits	263	Target Neighborhood Hits	960	Shared Neighborhood Hits	51
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

MA2A1_MOUSE
θ value	4.03905 (rank : 187)	NC score	0.011930 (rank : 353)
Query Neighborhood Hits	263	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	P27046	Gene names	Man2a1, Mana2
Domain Architecture
Description	Alpha-mannosidase 2 (EC 3.2.1.114) (Alpha-mannosidase II) (Mannosyl- oligosaccharide 1,3-1,6-alpha-mannosidase) (MAN II) (Golgi alpha- mannosidase II) (Mannosidase alpha class 2A member 1) (AMAN II).

RN169_HUMAN
θ value	4.03905 (rank : 188)	NC score	0.024238 (rank : 311)
Query Neighborhood Hits	263	Target Neighborhood Hits	203	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NCN4, Q6N015	Gene names	RNF169, KIAA1991
Domain Architecture	No domain graphic available
Description	RING finger protein 169.

SSA27_MOUSE
θ value	4.03905 (rank : 189)	NC score	0.026836 (rank : 301)
Query Neighborhood Hits	263	Target Neighborhood Hits	14	Shared Neighborhood Hits	7
SwissProt Accessions	P56873	Gene names	Sssca1, C184l
Domain Architecture
Description	Sjoegren syndrome/scleroderma autoantigen 1 homolog (Autoantigen p27 homolog) (Protein C184L).

SYNJ1_HUMAN
θ value	4.03905 (rank : 190)	NC score	0.036382 (rank : 268)
Query Neighborhood Hits	263	Target Neighborhood Hits	498	Shared Neighborhood Hits	54
SwissProt Accessions	O43426, O43425, O94984	Gene names	SYNJ1, KIAA0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

TCF8_MOUSE
θ value	4.03905 (rank : 191)	NC score	0.002080 (rank : 368)
Query Neighborhood Hits	263	Target Neighborhood Hits	1067	Shared Neighborhood Hits	32
SwissProt Accessions	Q64318, Q62519	Gene names	Tcf8, Zfhx1a, Zfx1a, Zfx1ha
Domain Architecture
Description	Transcription factor 8 (Zinc finger homeobox protein 1a) (MEB1) (Delta EF1).

ZFP38_HUMAN
θ value	4.03905 (rank : 192)	NC score	-0.002232 (rank : 372)
Query Neighborhood Hits	263	Target Neighborhood Hits	766	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y5A6, Q9H0B5	Gene names	ZNF38, ZFP38, ZSCAN21
Domain Architecture
Description	Zinc finger protein 38 homolog (Zfp-38) (Zinc finger and SCAN domain- containing protein 21) (NY-REN-21 antigen).

ZWINT_HUMAN
θ value	4.03905 (rank : 193)	NC score	0.025582 (rank : 305)
Query Neighborhood Hits	263	Target Neighborhood Hits	333	Shared Neighborhood Hits	22
SwissProt Accessions	O95229, Q9BWD0	Gene names	ZWINT
Domain Architecture	No domain graphic available
Description	ZW10 interactor (ZW10-interacting protein 1) (Zwint-1).

ABI2_MOUSE
θ value	5.27518 (rank : 194)	NC score	0.090783 (rank : 52)
Query Neighborhood Hits	263	Target Neighborhood Hits	266	Shared Neighborhood Hits	58
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

BAZ2B_HUMAN
θ value	5.27518 (rank : 195)	NC score	0.023269 (rank : 316)
Query Neighborhood Hits	263	Target Neighborhood Hits	803	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

EHMT1_HUMAN
θ value	5.27518 (rank : 196)	NC score	0.033147 (rank : 275)
Query Neighborhood Hits	263	Target Neighborhood Hits	417	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H9B1, Q8TCN7, Q96F53, Q96JF1, Q96KH4	Gene names	EHMT1, EUHMTASE1, KIAA1876
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a- like protein 1) (GLP1).

EVC_HUMAN
θ value	5.27518 (rank : 197)	NC score	0.028495 (rank : 293)
Query Neighborhood Hits	263	Target Neighborhood Hits	129	Shared Neighborhood Hits	9
SwissProt Accessions	P57679	Gene names	EVC
Domain Architecture	No domain graphic available
Description	Ellis-van Creveld syndrome protein (DWF-1).

IF4G1_MOUSE
θ value	5.27518 (rank : 198)	NC score	0.032846 (rank : 276)
Query Neighborhood Hits	263	Target Neighborhood Hits	534	Shared Neighborhood Hits	46
SwissProt Accessions	Q6NZJ6, Q6NZN8, Q8BW99	Gene names	Eif4g1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G1) (eIF-4G 1).

K0179_HUMAN
θ value	5.27518 (rank : 199)	NC score	0.030480 (rank : 285)
Query Neighborhood Hits	263	Target Neighborhood Hits	81	Shared Neighborhood Hits	9
SwissProt Accessions	Q14684, Q8TBZ4	Gene names	KIAA0179
Domain Architecture
Description	Protein KIAA0179.

KLDC1_MOUSE
θ value	5.27518 (rank : 200)	NC score	0.010111 (rank : 359)
Query Neighborhood Hits	263	Target Neighborhood Hits	68	Shared Neighborhood Hits	2
SwissProt Accessions	Q80YG3	Gene names	Klhdc1
Domain Architecture	No domain graphic available
Description	Kelch domain-containing protein 1.

MARK3_MOUSE
θ value	5.27518 (rank : 201)	NC score	0.024397 (rank : 310)
Query Neighborhood Hits	263	Target Neighborhood Hits	919	Shared Neighborhood Hits	50
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

MILK1_HUMAN
θ value	5.27518 (rank : 202)	NC score	0.030976 (rank : 283)
Query Neighborhood Hits	263	Target Neighborhood Hits	427	Shared Neighborhood Hits	42
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

NHS_HUMAN
θ value	5.27518 (rank : 203)	NC score	0.038425 (rank : 259)
Query Neighborhood Hits	263	Target Neighborhood Hits	198	Shared Neighborhood Hits	29
SwissProt Accessions	Q6T4R5, Q5J7Q0, Q5J7Q1, Q68DR5	Gene names	NHS
Domain Architecture	No domain graphic available
Description	Nance-Horan syndrome protein (Congenital cataracts and dental anomalies protein).

PRGC2_MOUSE
θ value	5.27518 (rank : 204)	NC score	0.022805 (rank : 320)
Query Neighborhood Hits	263	Target Neighborhood Hits	225	Shared Neighborhood Hits	20
SwissProt Accessions	Q8VHJ7, Q8C1C0	Gene names	Ppargc1b, Errl1, Pgc1, Pgc1b, Ppargc1
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPAR gamma coactivator-1beta protein) (PGC-1beta) (ERR ligand 1) (PPARGC-1-beta) (PGC-1-beta).

PWWP2_HUMAN
θ value	5.27518 (rank : 205)	NC score	0.030352 (rank : 286)
Query Neighborhood Hits	263	Target Neighborhood Hits	80	Shared Neighborhood Hits	14
SwissProt Accessions	Q6NUJ5, Q5SZI0, Q6ZQX5, Q96F43	Gene names	PWWP2
Domain Architecture	No domain graphic available
Description	PWWP domain-containing protein 2.

RAPH1_HUMAN
θ value	5.27518 (rank : 206)	NC score	0.051793 (rank : 216)
Query Neighborhood Hits	263	Target Neighborhood Hits	593	Shared Neighborhood Hits	68
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

SHAN2_MOUSE
θ value	5.27518 (rank : 207)	NC score	0.083634 (rank : 71)
Query Neighborhood Hits	263	Target Neighborhood Hits	446	Shared Neighborhood Hits	95
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

SRBS1_HUMAN
θ value	5.27518 (rank : 208)	NC score	0.109710 (rank : 32)
Query Neighborhood Hits	263	Target Neighborhood Hits	396	Shared Neighborhood Hits	69
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
θ value	5.27518 (rank : 209)	NC score	0.108195 (rank : 33)
Query Neighborhood Hits	263	Target Neighborhood Hits	409	Shared Neighborhood Hits	76
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SVIL_MOUSE
θ value	5.27518 (rank : 210)	NC score	0.026314 (rank : 302)
Query Neighborhood Hits	263	Target Neighborhood Hits	439	Shared Neighborhood Hits	36
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

TULP1_MOUSE
θ value	5.27518 (rank : 211)	NC score	0.015742 (rank : 343)
Query Neighborhood Hits	263	Target Neighborhood Hits	146	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Z273	Gene names	Tulp1
Domain Architecture
Description	Tubby-related protein 1 (Tubby-like protein 1).

ZN358_HUMAN
θ value	5.27518 (rank : 212)	NC score	-0.000231 (rank : 369)
Query Neighborhood Hits	263	Target Neighborhood Hits	840	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NW07, Q9BTM7	Gene names	ZNF358
Domain Architecture
Description	Zinc finger protein 358.

ABI2_HUMAN
θ value	6.88961 (rank : 213)	NC score	0.097893 (rank : 43)
Query Neighborhood Hits	263	Target Neighborhood Hits	350	Shared Neighborhood Hits	75
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

ACM4_MOUSE
θ value	6.88961 (rank : 214)	NC score	-0.002867 (rank : 373)
Query Neighborhood Hits	263	Target Neighborhood Hits	894	Shared Neighborhood Hits	7
SwissProt Accessions	P32211, Q64056	Gene names	Chrm4, Chrm-4
Domain Architecture
Description	Muscarinic acetylcholine receptor M4 (Mm4 mAChR).

BORG1_HUMAN
θ value	6.88961 (rank : 215)	NC score	0.019240 (rank : 331)
Query Neighborhood Hits	263	Target Neighborhood Hits	67	Shared Neighborhood Hits	11
SwissProt Accessions	O14613, Q9UNS0	Gene names	CDC42EP2, BORG1, CEP2
Domain Architecture	No domain graphic available
Description	Cdc42 effector protein 2 (Binder of Rho GTPases 1).

CASG_MOUSE
θ value	6.88961 (rank : 216)	NC score	0.066992 (rank : 123)
Query Neighborhood Hits	263	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	Q02862	Gene names	Csng
Domain Architecture	No domain graphic available
Description	Gamma-casein precursor (PP22).

CDN1B_HUMAN
θ value	6.88961 (rank : 217)	NC score	0.018078 (rank : 335)
Query Neighborhood Hits	263	Target Neighborhood Hits	27	Shared Neighborhood Hits	7
SwissProt Accessions	P46527, Q16307, Q9BUS6	Gene names	CDKN1B, KIP1
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1).

CIR_MOUSE
θ value	6.88961 (rank : 218)	NC score	0.017503 (rank : 339)
Query Neighborhood Hits	263	Target Neighborhood Hits	255	Shared Neighborhood Hits	13
SwissProt Accessions	Q9DA19, Q3V2N9, Q4KL44, Q52KL9, Q5FW66	Gene names	Cir
Domain Architecture	No domain graphic available
Description	CBF1-interacting corepressor.

DACH2_HUMAN
θ value	6.88961 (rank : 219)	NC score	0.010243 (rank : 357)
Query Neighborhood Hits	263	Target Neighborhood Hits	122	Shared Neighborhood Hits	5
SwissProt Accessions	Q96NX9, Q8NAY3, Q8ND17, Q96N55	Gene names	DACH2
Domain Architecture
Description	Dachshund homolog 2 (Dach2).

DDEF2_MOUSE
θ value	6.88961 (rank : 220)	NC score	0.062975 (rank : 143)
Query Neighborhood Hits	263	Target Neighborhood Hits	625	Shared Neighborhood Hits	81
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

HRX_HUMAN
θ value	6.88961 (rank : 221)	NC score	0.043988 (rank : 249)
Query Neighborhood Hits	263	Target Neighborhood Hits	825	Shared Neighborhood Hits	63
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

I17RD_MOUSE
θ value	6.88961 (rank : 222)	NC score	0.012368 (rank : 351)
Query Neighborhood Hits	263	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q8JZL1, Q8K447, Q8R5J8	Gene names	Il17rd, Il17rlm, Sef
Domain Architecture	No domain graphic available
Description	Interleukin-17 receptor D precursor (IL-17 receptor D) (IL-17RD) (Interleukin-17D receptor) (IL-17D receptor) (Interleukin-17 receptor- like protein) (Sef homolog) (mSef).

INSM1_MOUSE
θ value	6.88961 (rank : 223)	NC score	0.003382 (rank : 365)
Query Neighborhood Hits	263	Target Neighborhood Hits	678	Shared Neighborhood Hits	14
SwissProt Accessions	Q63ZV0, Q9Z113	Gene names	Insm1, Ia1
Domain Architecture	No domain graphic available
Description	Insulinoma-associated protein 1 (Zinc finger protein IA-1).

MLL4_HUMAN
θ value	6.88961 (rank : 224)	NC score	0.048518 (rank : 241)
Query Neighborhood Hits	263	Target Neighborhood Hits	722	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

MYO1F_MOUSE
θ value	6.88961 (rank : 225)	NC score	0.051219 (rank : 224)
Query Neighborhood Hits	263	Target Neighborhood Hits	262	Shared Neighborhood Hits	55
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

NCK1_HUMAN
θ value	6.88961 (rank : 226)	NC score	0.090180 (rank : 54)
Query Neighborhood Hits	263	Target Neighborhood Hits	312	Shared Neighborhood Hits	51
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

NEMO_MOUSE
θ value	6.88961 (rank : 227)	NC score	0.011792 (rank : 354)
Query Neighborhood Hits	263	Target Neighborhood Hits	658	Shared Neighborhood Hits	27
SwissProt Accessions	O88522	Gene names	Ikbkg, Nemo
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3).

NOL10_MOUSE
θ value	6.88961 (rank : 228)	NC score	0.011355 (rank : 355)
Query Neighborhood Hits	263	Target Neighborhood Hits	206	Shared Neighborhood Hits	7
SwissProt Accessions	Q5RJG1	Gene names	Nol10, Gm67
Domain Architecture	No domain graphic available
Description	Nucleolar protein 10.

PLCB1_HUMAN
θ value	6.88961 (rank : 229)	NC score	0.019464 (rank : 330)
Query Neighborhood Hits	263	Target Neighborhood Hits	614	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NQ66, O60325, Q5TFF7, Q5TGC9, Q8IV93, Q9BQW2, Q9H4H2, Q9H8H5, Q9NQ65, Q9NQH9, Q9NTH4, Q9UJP6, Q9UM26	Gene names	PLCB1, KIAA0581
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

PLCB1_MOUSE
θ value	6.88961 (rank : 230)	NC score	0.013336 (rank : 349)
Query Neighborhood Hits	263	Target Neighborhood Hits	531	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z1B3, Q62075, Q8K5A5, Q8K5A6, Q9Z0E5, Q9Z2T5	Gene names	Plcb1, Plcb
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

PSL1_HUMAN
θ value	6.88961 (rank : 231)	NC score	0.049133 (rank : 240)
Query Neighborhood Hits	263	Target Neighborhood Hits	650	Shared Neighborhood Hits	61
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

RERE_HUMAN
θ value	6.88961 (rank : 232)	NC score	0.037152 (rank : 262)
Query Neighborhood Hits	263	Target Neighborhood Hits	779	Shared Neighborhood Hits	48
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

REST_MOUSE
θ value	6.88961 (rank : 233)	NC score	0.009637 (rank : 361)
Query Neighborhood Hits	263	Target Neighborhood Hits	1506	Shared Neighborhood Hits	52
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

SDCG1_MOUSE
θ value	6.88961 (rank : 234)	NC score	0.016683 (rank : 341)
Query Neighborhood Hits	263	Target Neighborhood Hits	168	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CCP0, Q66JX6, Q8C9R6, Q8CA65, Q8JZT9, Q8R072, Q9CW30, Q9CYB8, Q9D4A9	Gene names	Sdccag1
Domain Architecture
Description	Serologically defined colon cancer antigen 1.

T22D4_HUMAN
θ value	6.88961 (rank : 235)	NC score	0.031496 (rank : 280)
Query Neighborhood Hits	263	Target Neighborhood Hits	403	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y3Q8	Gene names	TSC22D4, TILZ2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1).

THAP7_HUMAN
θ value	6.88961 (rank : 236)	NC score	0.024968 (rank : 309)
Query Neighborhood Hits	263	Target Neighborhood Hits	59	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BT49	Gene names	THAP7
Domain Architecture
Description	THAP domain-containing protein 7.

TLE4_HUMAN
θ value	6.88961 (rank : 237)	NC score	0.014119 (rank : 346)
Query Neighborhood Hits	263	Target Neighborhood Hits	477	Shared Neighborhood Hits	30
SwissProt Accessions	Q04727, Q5T1Y2, Q9BZ07, Q9BZ08, Q9BZ09, Q9NSL3, Q9ULF9	Gene names	TLE4, KIAA1261
Domain Architecture
Description	Transducin-like enhancer protein 4.

ZBT17_MOUSE
θ value	6.88961 (rank : 238)	NC score	-0.002211 (rank : 371)
Query Neighborhood Hits	263	Target Neighborhood Hits	940	Shared Neighborhood Hits	17
SwissProt Accessions	Q60821, Q60699	Gene names	Zbtb17, Zfp100, Znf151
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 17 (Zinc finger protein 151) (Zinc finger protein 100) (Zfp-100) (Polyomavirus late initiator promoter-binding protein) (LP-1) (Zinc finger protein Z13).

ATX7_HUMAN
θ value	8.99809 (rank : 239)	NC score	0.036606 (rank : 266)
Query Neighborhood Hits	263	Target Neighborhood Hits	351	Shared Neighborhood Hits	41
SwissProt Accessions	O15265, O75328, O75329, Q9Y6P8	Gene names	ATXN7, SCA7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein).

BAZ2A_HUMAN
θ value	8.99809 (rank : 240)	NC score	0.029127 (rank : 289)
Query Neighborhood Hits	263	Target Neighborhood Hits	780	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UIF9, O00536, O15030, Q96H26	Gene names	BAZ2A, KIAA0314, TIP5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3).

CDT1_MOUSE
θ value	8.99809 (rank : 241)	NC score	0.022972 (rank : 318)
Query Neighborhood Hits	263	Target Neighborhood Hits	72	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R4E9, Q8BUQ1, Q8BX29, Q8R3V0, Q8R4E8	Gene names	Cdt1, Ris2
Domain Architecture	No domain graphic available
Description	DNA replication factor Cdt1 (Double parked homolog) (DUP) (Retroviral insertion site 2 protein).

CEND3_MOUSE
θ value	8.99809 (rank : 242)	NC score	0.059264 (rank : 169)
Query Neighborhood Hits	263	Target Neighborhood Hits	228	Shared Neighborhood Hits	51
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

CSF2R_HUMAN
θ value	8.99809 (rank : 243)	NC score	0.009836 (rank : 360)
Query Neighborhood Hits	263	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	P15509, O00207, Q14429, Q14430, Q14431, Q16564	Gene names	CSF2RA, CSF2R
Domain Architecture	No domain graphic available
Description	Granulocyte-macrophage colony-stimulating factor receptor alpha chain precursor (GM-CSF-R-alpha) (GMR) (CD116 antigen) (CDw116).

DSPP_MOUSE
θ value	8.99809 (rank : 244)	NC score	0.018738 (rank : 332)
Query Neighborhood Hits	263	Target Neighborhood Hits	491	Shared Neighborhood Hits	25
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

FGFR1_HUMAN
θ value	8.99809 (rank : 245)	NC score	0.037060 (rank : 264)
Query Neighborhood Hits	263	Target Neighborhood Hits	1069	Shared Neighborhood Hits	42
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

FGFR1_MOUSE
θ value	8.99809 (rank : 246)	NC score	0.037081 (rank : 263)
Query Neighborhood Hits	263	Target Neighborhood Hits	1068	Shared Neighborhood Hits	42
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FHOD1_HUMAN
θ value	8.99809 (rank : 247)	NC score	0.023690 (rank : 315)
Query Neighborhood Hits	263	Target Neighborhood Hits	184	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y613, Q59F76, Q6Y1F2, Q76MS8, Q8N521	Gene names	FHOD1, FHOS
Domain Architecture
Description	FH1/FH2 domain-containing protein (Formin homolog overexpressed in spleen) (FHOS) (Formin homology 2 domain-containing protein 1).

FYCO1_MOUSE
θ value	8.99809 (rank : 248)	NC score	0.005543 (rank : 363)
Query Neighborhood Hits	263	Target Neighborhood Hits	1059	Shared Neighborhood Hits	26
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

KI21A_HUMAN
θ value	8.99809 (rank : 249)	NC score	0.007571 (rank : 362)
Query Neighborhood Hits	263	Target Neighborhood Hits	1543	Shared Neighborhood Hits	51
SwissProt Accessions	Q7Z4S6, Q6UKL9, Q7Z668, Q86WZ5, Q8IVZ8, Q9C0F5, Q9NXU4, Q9Y590	Gene names	KIF21A, KIAA1708, KIF2
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A (Kinesin-like protein KIF2) (NY-REN-62 antigen).

NFL_HUMAN
θ value	8.99809 (rank : 250)	NC score	0.010889 (rank : 356)
Query Neighborhood Hits	263	Target Neighborhood Hits	666	Shared Neighborhood Hits	21
SwissProt Accessions	P07196, Q16154, Q8IU72	Gene names	NEFL, NF68, NFL
Domain Architecture
Description	Neurofilament triplet L protein (68 kDa neurofilament protein) (Neurofilament light polypeptide) (NF-L).

OBSCN_HUMAN
θ value	8.99809 (rank : 251)	NC score	0.025097 (rank : 308)
Query Neighborhood Hits	263	Target Neighborhood Hits	1931	Shared Neighborhood Hits	91
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

PRGR_MOUSE
θ value	8.99809 (rank : 252)	NC score	0.010179 (rank : 358)
Query Neighborhood Hits	263	Target Neighborhood Hits	286	Shared Neighborhood Hits	27
SwissProt Accessions	Q00175	Gene names	Pgr, Nr3c3, Pr
Domain Architecture
Description	Progesterone receptor (PR).

SGIP1_HUMAN
θ value	8.99809 (rank : 253)	NC score	0.031060 (rank : 282)
Query Neighborhood Hits	263	Target Neighborhood Hits	198	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BQI5, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2	Gene names	SGIP1
Domain Architecture	No domain graphic available
Description	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin- 3-interacting protein).

SH3G1_HUMAN
θ value	8.99809 (rank : 254)	NC score	0.076003 (rank : 102)
Query Neighborhood Hits	263	Target Neighborhood Hits	307	Shared Neighborhood Hits	59
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

SH3G1_MOUSE
θ value	8.99809 (rank : 255)	NC score	0.077901 (rank : 99)
Query Neighborhood Hits	263	Target Neighborhood Hits	291	Shared Neighborhood Hits	58
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

SH3G2_MOUSE
θ value	8.99809 (rank : 256)	NC score	0.090293 (rank : 53)
Query Neighborhood Hits	263	Target Neighborhood Hits	319	Shared Neighborhood Hits	57
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

SYK_MOUSE
θ value	8.99809 (rank : 257)	NC score	0.020446 (rank : 328)
Query Neighborhood Hits	263	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q99MN1	Gene names	Kars
Domain Architecture
Description	Lysyl-tRNA synthetase (EC 6.1.1.6) (Lysine--tRNA ligase) (LysRS).

TLE1_HUMAN
θ value	8.99809 (rank : 258)	NC score	0.014797 (rank : 344)
Query Neighborhood Hits	263	Target Neighborhood Hits	485	Shared Neighborhood Hits	26
SwissProt Accessions	Q04724, Q5T3G4, Q969V9	Gene names	TLE1
Domain Architecture
Description	Transducin-like enhancer protein 1 (ESG1) (E(Sp1) homolog).

TLE4_MOUSE
θ value	8.99809 (rank : 259)	NC score	0.013257 (rank : 350)
Query Neighborhood Hits	263	Target Neighborhood Hits	482	Shared Neighborhood Hits	31
SwissProt Accessions	Q62441, Q9JKQ9	Gene names	Tle4, Grg4
Domain Architecture
Description	Transducin-like enhancer protein 4 (Groucho-related protein 4) (Grg- 4).

WASF4_HUMAN
θ value	8.99809 (rank : 260)	NC score	0.030777 (rank : 284)
Query Neighborhood Hits	263	Target Neighborhood Hits	282	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IV90	Gene names	WASF4, SCAR2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 4 (WASP-family protein member 4).

WASIP_HUMAN
θ value	8.99809 (rank : 261)	NC score	0.074068 (rank : 106)
Query Neighborhood Hits	263	Target Neighborhood Hits	458	Shared Neighborhood Hits	53
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

WDR67_HUMAN
θ value	8.99809 (rank : 262)	NC score	0.014420 (rank : 345)
Query Neighborhood Hits	263	Target Neighborhood Hits	782	Shared Neighborhood Hits	32
SwissProt Accessions	Q96DN5, Q3MIR6, Q8TBP9	Gene names	WDR67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67.

ZBTB5_HUMAN
θ value	8.99809 (rank : 263)	NC score	0.002288 (rank : 367)
Query Neighborhood Hits	263	Target Neighborhood Hits	811	Shared Neighborhood Hits	12
SwissProt Accessions	O15062	Gene names	ZBTB5, KIAA0354
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 5.

ABI1_HUMAN
θ value	θ > 10 (rank : 264)	NC score	0.065030 (rank : 130)
Query Neighborhood Hits	263	Target Neighborhood Hits	257	Shared Neighborhood Hits	58
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

ABI1_MOUSE
θ value	θ > 10 (rank : 265)	NC score	0.062876 (rank : 144)
Query Neighborhood Hits	263	Target Neighborhood Hits	246	Shared Neighborhood Hits	52
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

ABI3_HUMAN
θ value	θ > 10 (rank : 266)	NC score	0.067259 (rank : 122)
Query Neighborhood Hits	263	Target Neighborhood Hits	227	Shared Neighborhood Hits	60
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABI3_MOUSE
θ value	θ > 10 (rank : 267)	NC score	0.058016 (rank : 176)
Query Neighborhood Hits	263	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

ABL1_HUMAN
θ value	θ > 10 (rank : 268)	NC score	0.053330 (rank : 201)
Query Neighborhood Hits	263	Target Neighborhood Hits	1220	Shared Neighborhood Hits	99
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL1_MOUSE
θ value	θ > 10 (rank : 269)	NC score	0.060385 (rank : 166)
Query Neighborhood Hits	263	Target Neighborhood Hits	1178	Shared Neighborhood Hits	100
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

ABL2_HUMAN
θ value	θ > 10 (rank : 270)	NC score	0.050782 (rank : 229)
Query Neighborhood Hits	263	Target Neighborhood Hits	1045	Shared Neighborhood Hits	78
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

ARHG4_HUMAN
θ value	θ > 10 (rank : 271)	NC score	0.060835 (rank : 162)
Query Neighborhood Hits	263	Target Neighborhood Hits	242	Shared Neighborhood Hits	49
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG4_MOUSE
θ value	θ > 10 (rank : 272)	NC score	0.059138 (rank : 171)
Query Neighborhood Hits	263	Target Neighborhood Hits	185	Shared Neighborhood Hits	45
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

ARHG9_HUMAN
θ value	θ > 10 (rank : 273)	NC score	0.057602 (rank : 179)
Query Neighborhood Hits	263	Target Neighborhood Hits	235	Shared Neighborhood Hits	51
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

ARHG9_MOUSE
θ value	θ > 10 (rank : 274)	NC score	0.057118 (rank : 181)
Query Neighborhood Hits	263	Target Neighborhood Hits	234	Shared Neighborhood Hits	51
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

ASPP1_HUMAN
θ value	θ > 10 (rank : 275)	NC score	0.053895 (rank : 198)
Query Neighborhood Hits	263	Target Neighborhood Hits	956	Shared Neighborhood Hits	87
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

ASPP1_MOUSE
θ value	θ > 10 (rank : 276)	NC score	0.064090 (rank : 138)
Query Neighborhood Hits	263	Target Neighborhood Hits	1244	Shared Neighborhood Hits	111
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

BCAR1_HUMAN
θ value	θ > 10 (rank : 277)	NC score	0.064325 (rank : 134)
Query Neighborhood Hits	263	Target Neighborhood Hits	554	Shared Neighborhood Hits	84
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BCAR1_MOUSE
θ value	θ > 10 (rank : 278)	NC score	0.059709 (rank : 168)
Query Neighborhood Hits	263	Target Neighborhood Hits	438	Shared Neighborhood Hits	77
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

BLK_MOUSE
θ value	θ > 10 (rank : 279)	NC score	0.050025 (rank : 239)
Query Neighborhood Hits	263	Target Neighborhood Hits	992	Shared Neighborhood Hits	75
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

BSN_HUMAN
θ value	θ > 10 (rank : 280)	NC score	0.057708 (rank : 178)
Query Neighborhood Hits	263	Target Neighborhood Hits	1537	Shared Neighborhood Hits	90
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

BTK_HUMAN
θ value	θ > 10 (rank : 281)	NC score	0.053096 (rank : 203)
Query Neighborhood Hits	263	Target Neighborhood Hits	1026	Shared Neighborhood Hits	83
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

BTK_MOUSE
θ value	θ > 10 (rank : 282)	NC score	0.052657 (rank : 205)
Query Neighborhood Hits	263	Target Neighborhood Hits	1017	Shared Neighborhood Hits	83
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

CASL_MOUSE
θ value	θ > 10 (rank : 283)	NC score	0.050255 (rank : 236)
Query Neighborhood Hits	263	Target Neighborhood Hits	225	Shared Neighborhood Hits	57
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

CK024_HUMAN
θ value	θ > 10 (rank : 284)	NC score	0.051187 (rank : 225)
Query Neighborhood Hits	263	Target Neighborhood Hits	408	Shared Neighborhood Hits	46
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

CN155_HUMAN
θ value	θ > 10 (rank : 285)	NC score	0.050350 (rank : 233)
Query Neighborhood Hits	263	Target Neighborhood Hits	385	Shared Neighborhood Hits	38
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

CSK_HUMAN
θ value	θ > 10 (rank : 286)	NC score	0.051715 (rank : 217)
Query Neighborhood Hits	263	Target Neighborhood Hits	1009	Shared Neighborhood Hits	75
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

CSK_MOUSE
θ value	θ > 10 (rank : 287)	NC score	0.051304 (rank : 221)
Query Neighborhood Hits	263	Target Neighborhood Hits	1009	Shared Neighborhood Hits	75
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

CT032_HUMAN
θ value	θ > 10 (rank : 288)	NC score	0.064129 (rank : 137)
Query Neighborhood Hits	263	Target Neighborhood Hits	235	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

DBNL_HUMAN
θ value	θ > 10 (rank : 289)	NC score	0.054556 (rank : 194)
Query Neighborhood Hits	263	Target Neighborhood Hits	244	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

DBNL_MOUSE
θ value	θ > 10 (rank : 290)	NC score	0.055961 (rank : 186)
Query Neighborhood Hits	263	Target Neighborhood Hits	306	Shared Neighborhood Hits	58
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

DDEF1_MOUSE
θ value	θ > 10 (rank : 291)	NC score	0.063971 (rank : 139)
Query Neighborhood Hits	263	Target Neighborhood Hits	592	Shared Neighborhood Hits	78
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

DDEF2_HUMAN
θ value	θ > 10 (rank : 292)	NC score	0.060595 (rank : 165)
Query Neighborhood Hits	263	Target Neighborhood Hits	599	Shared Neighborhood Hits	77
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

DNMBP_HUMAN
θ value	θ > 10 (rank : 293)	NC score	0.068273 (rank : 120)
Query Neighborhood Hits	263	Target Neighborhood Hits	413	Shared Neighborhood Hits	56
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

DNMBP_MOUSE
θ value	θ > 10 (rank : 294)	NC score	0.073547 (rank : 107)
Query Neighborhood Hits	263	Target Neighborhood Hits	435	Shared Neighborhood Hits	67
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

EFS_HUMAN
θ value	θ > 10 (rank : 295)	NC score	0.051375 (rank : 220)
Query Neighborhood Hits	263	Target Neighborhood Hits	348	Shared Neighborhood Hits	68
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

EFS_MOUSE
θ value	θ > 10 (rank : 296)	NC score	0.055574 (rank : 190)
Query Neighborhood Hits	263	Target Neighborhood Hits	389	Shared Neighborhood Hits	72
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

EPHA3_HUMAN
θ value	θ > 10 (rank : 297)	NC score	0.069393 (rank : 119)
Query Neighborhood Hits	263	Target Neighborhood Hits	1005	Shared Neighborhood Hits	44
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

EPHA3_MOUSE
θ value	θ > 10 (rank : 298)	NC score	0.069737 (rank : 117)
Query Neighborhood Hits	263	Target Neighborhood Hits	1009	Shared Neighborhood Hits	44
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

FA47A_HUMAN
θ value	θ > 10 (rank : 299)	NC score	0.078211 (rank : 97)
Query Neighborhood Hits	263	Target Neighborhood Hits	451	Shared Neighborhood Hits	62
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

FGR_HUMAN
θ value	θ > 10 (rank : 300)	NC score	0.055149 (rank : 193)
Query Neighborhood Hits	263	Target Neighborhood Hits	1067	Shared Neighborhood Hits	82
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FGR_MOUSE
θ value	θ > 10 (rank : 301)	NC score	0.054244 (rank : 196)
Query Neighborhood Hits	263	Target Neighborhood Hits	1069	Shared Neighborhood Hits	82
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

FRK_HUMAN
θ value	θ > 10 (rank : 302)	NC score	0.050828 (rank : 228)
Query Neighborhood Hits	263	Target Neighborhood Hits	1058	Shared Neighborhood Hits	82
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

FYN_HUMAN
θ value	θ > 10 (rank : 303)	NC score	0.054500 (rank : 195)
Query Neighborhood Hits	263	Target Neighborhood Hits	1078	Shared Neighborhood Hits	82
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FYN_MOUSE
θ value	θ > 10 (rank : 304)	NC score	0.055717 (rank : 188)
Query Neighborhood Hits	263	Target Neighborhood Hits	1073	Shared Neighborhood Hits	83
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

GRB2_HUMAN
θ value	θ > 10 (rank : 305)	NC score	0.082492 (rank : 75)
Query Neighborhood Hits	263	Target Neighborhood Hits	310	Shared Neighborhood Hits	52
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

GRB2_MOUSE
θ value	θ > 10 (rank : 306)	NC score	0.082308 (rank : 77)
Query Neighborhood Hits	263	Target Neighborhood Hits	312	Shared Neighborhood Hits	52
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

HCK_HUMAN
θ value	θ > 10 (rank : 307)	NC score	0.052288 (rank : 208)
Query Neighborhood Hits	263	Target Neighborhood Hits	1035	Shared Neighborhood Hits	80
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

HCK_MOUSE
θ value	θ > 10 (rank : 308)	NC score	0.052371 (rank : 207)
Query Neighborhood Hits	263	Target Neighborhood Hits	1029	Shared Neighborhood Hits	81
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

HCLS1_HUMAN
θ value	θ > 10 (rank : 309)	NC score	0.082634 (rank : 73)
Query Neighborhood Hits	263	Target Neighborhood Hits	358	Shared Neighborhood Hits	78
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

HCLS1_MOUSE
θ value	θ > 10 (rank : 310)	NC score	0.070224 (rank : 116)
Query Neighborhood Hits	263	Target Neighborhood Hits	329	Shared Neighborhood Hits	65
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

IASPP_HUMAN
θ value	θ > 10 (rank : 311)	NC score	0.051894 (rank : 212)
Query Neighborhood Hits	263	Target Neighborhood Hits	688	Shared Neighborhood Hits	81
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

IASPP_MOUSE
θ value	θ > 10 (rank : 312)	NC score	0.066405 (rank : 125)
Query Neighborhood Hits	263	Target Neighborhood Hits	1024	Shared Neighborhood Hits	100
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

ILK1_HUMAN
θ value	θ > 10 (rank : 313)	NC score	0.050120 (rank : 238)
Query Neighborhood Hits	263	Target Neighborhood Hits	857	Shared Neighborhood Hits	47
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

ILK2_HUMAN
θ value	θ > 10 (rank : 314)	NC score	0.050268 (rank : 235)
Query Neighborhood Hits	263	Target Neighborhood Hits	848	Shared Neighborhood Hits	47
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

ILK_MOUSE
θ value	θ > 10 (rank : 315)	NC score	0.050440 (rank : 231)
Query Neighborhood Hits	263	Target Neighborhood Hits	858	Shared Neighborhood Hits	48
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

K1802_MOUSE
θ value	θ > 10 (rank : 316)	NC score	0.056647 (rank : 185)
Query Neighborhood Hits	263	Target Neighborhood Hits	1596	Shared Neighborhood Hits	82
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

LAD1_MOUSE
θ value	θ > 10 (rank : 317)	NC score	0.052082 (rank : 209)
Query Neighborhood Hits	263	Target Neighborhood Hits	391	Shared Neighborhood Hits	42
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

LCP2_HUMAN
θ value	θ > 10 (rank : 318)	NC score	0.066639 (rank : 124)
Query Neighborhood Hits	263	Target Neighborhood Hits	531	Shared Neighborhood Hits	57
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

LYN_HUMAN
θ value	θ > 10 (rank : 319)	NC score	0.051835 (rank : 213)
Query Neighborhood Hits	263	Target Neighborhood Hits	1022	Shared Neighborhood Hits	80
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

LYN_MOUSE
θ value	θ > 10 (rank : 320)	NC score	0.051544 (rank : 219)
Query Neighborhood Hits	263	Target Neighborhood Hits	1023	Shared Neighborhood Hits	79
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

M3KL4_HUMAN
θ value	θ > 10 (rank : 321)	NC score	0.051969 (rank : 211)
Query Neighborhood Hits	263	Target Neighborhood Hits	1087	Shared Neighborhood Hits	86
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

MAP4_HUMAN
θ value	θ > 10 (rank : 322)	NC score	0.051237 (rank : 223)
Query Neighborhood Hits	263	Target Neighborhood Hits	428	Shared Neighborhood Hits	47
SwissProt Accessions	P27816, Q13082, Q96A76	Gene names	MAP4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

MDC1_MOUSE
θ value	θ > 10 (rank : 323)	NC score	0.077245 (rank : 100)
Query Neighborhood Hits	263	Target Neighborhood Hits	998	Shared Neighborhood Hits	79
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

MLL2_HUMAN
θ value	θ > 10 (rank : 324)	NC score	0.050162 (rank : 237)
Query Neighborhood Hits	263	Target Neighborhood Hits	1788	Shared Neighborhood Hits	100
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

MUC7_HUMAN
θ value	θ > 10 (rank : 325)	NC score	0.051598 (rank : 218)
Query Neighborhood Hits	263	Target Neighborhood Hits	538	Shared Neighborhood Hits	51
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

NCF1_HUMAN
θ value	θ > 10 (rank : 326)	NC score	0.080135 (rank : 86)
Query Neighborhood Hits	263	Target Neighborhood Hits	198	Shared Neighborhood Hits	48
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

NCF2_HUMAN
θ value	θ > 10 (rank : 327)	NC score	0.081561 (rank : 81)
Query Neighborhood Hits	263	Target Neighborhood Hits	229	Shared Neighborhood Hits	50
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

NCF4_HUMAN
θ value	θ > 10 (rank : 328)	NC score	0.063970 (rank : 140)
Query Neighborhood Hits	263	Target Neighborhood Hits	161	Shared Neighborhood Hits	45
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCF4_MOUSE
θ value	θ > 10 (rank : 329)	NC score	0.065883 (rank : 129)
Query Neighborhood Hits	263	Target Neighborhood Hits	177	Shared Neighborhood Hits	48
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

NCOA6_HUMAN
θ value	θ > 10 (rank : 330)	NC score	0.055637 (rank : 189)
Query Neighborhood Hits	263	Target Neighborhood Hits	1202	Shared Neighborhood Hits	82
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

NEBL_HUMAN
θ value	θ > 10 (rank : 331)	NC score	0.050485 (rank : 230)
Query Neighborhood Hits	263	Target Neighborhood Hits	457	Shared Neighborhood Hits	59
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

NOXO1_MOUSE
θ value	θ > 10 (rank : 332)	NC score	0.056754 (rank : 184)
Query Neighborhood Hits	263	Target Neighborhood Hits	114	Shared Neighborhood Hits	36
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

NPHP1_HUMAN
θ value	θ > 10 (rank : 333)	NC score	0.061262 (rank : 158)
Query Neighborhood Hits	263	Target Neighborhood Hits	288	Shared Neighborhood Hits	43
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

OSTF1_HUMAN
θ value	θ > 10 (rank : 334)	NC score	0.084335 (rank : 68)
Query Neighborhood Hits	263	Target Neighborhood Hits	466	Shared Neighborhood Hits	61
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

OSTF1_MOUSE
θ value	θ > 10 (rank : 335)	NC score	0.085936 (rank : 62)
Query Neighborhood Hits	263	Target Neighborhood Hits	467	Shared Neighborhood Hits	62
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

PACN2_HUMAN
θ value	θ > 10 (rank : 336)	NC score	0.053429 (rank : 200)
Query Neighborhood Hits	263	Target Neighborhood Hits	339	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_MOUSE
θ value	θ > 10 (rank : 337)	NC score	0.053793 (rank : 199)
Query Neighborhood Hits	263	Target Neighborhood Hits	382	Shared Neighborhood Hits	57
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PLCG1_HUMAN
θ value	θ > 10 (rank : 338)	NC score	0.061688 (rank : 154)
Query Neighborhood Hits	263	Target Neighborhood Hits	293	Shared Neighborhood Hits	52
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG1_MOUSE
θ value	θ > 10 (rank : 339)	NC score	0.062391 (rank : 147)
Query Neighborhood Hits	263	Target Neighborhood Hits	314	Shared Neighborhood Hits	54
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PLCG2_HUMAN
θ value	θ > 10 (rank : 340)	NC score	0.055271 (rank : 192)
Query Neighborhood Hits	263	Target Neighborhood Hits	280	Shared Neighborhood Hits	50
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

PPIP1_HUMAN
θ value	θ > 10 (rank : 341)	NC score	0.062811 (rank : 145)
Query Neighborhood Hits	263	Target Neighborhood Hits	389	Shared Neighborhood Hits	52
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

PPIP1_MOUSE
θ value	θ > 10 (rank : 342)	NC score	0.061603 (rank : 155)
Query Neighborhood Hits	263	Target Neighborhood Hits	377	Shared Neighborhood Hits	53
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

PRR13_HUMAN
θ value	θ > 10 (rank : 343)	NC score	0.061940 (rank : 152)
Query Neighborhood Hits	263	Target Neighborhood Hits	105	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NZ81, Q6FIG7, Q6MZP8, Q6NXQ6, Q6PKF9	Gene names	PRR13
Domain Architecture	No domain graphic available
Description	Proline-rich protein 13.

PRRT3_HUMAN
θ value	θ > 10 (rank : 344)	NC score	0.057035 (rank : 182)
Query Neighborhood Hits	263	Target Neighborhood Hits	998	Shared Neighborhood Hits	71
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

SH3G2_HUMAN
θ value	θ > 10 (rank : 345)	NC score	0.077978 (rank : 98)
Query Neighborhood Hits	263	Target Neighborhood Hits	324	Shared Neighborhood Hits	53
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G3_HUMAN
θ value	θ > 10 (rank : 346)	NC score	0.070873 (rank : 113)
Query Neighborhood Hits	263	Target Neighborhood Hits	222	Shared Neighborhood Hits	54
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

SHAN1_HUMAN
θ value	θ > 10 (rank : 347)	NC score	0.069557 (rank : 118)
Query Neighborhood Hits	263	Target Neighborhood Hits	1041	Shared Neighborhood Hits	103
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

SON_MOUSE
θ value	θ > 10 (rank : 348)	NC score	0.052426 (rank : 206)
Query Neighborhood Hits	263	Target Neighborhood Hits	957	Shared Neighborhood Hits	70
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

SPR1B_MOUSE
θ value	θ > 10 (rank : 349)	NC score	0.050423 (rank : 232)
Query Neighborhood Hits	263	Target Neighborhood Hits	395	Shared Neighborhood Hits	46
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

SRC8_HUMAN
θ value	θ > 10 (rank : 350)	NC score	0.062221 (rank : 149)
Query Neighborhood Hits	263	Target Neighborhood Hits	269	Shared Neighborhood Hits	50
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

SRC8_MOUSE
θ value	θ > 10 (rank : 351)	NC score	0.063151 (rank : 142)
Query Neighborhood Hits	263	Target Neighborhood Hits	292	Shared Neighborhood Hits	54
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

SRC_HUMAN
θ value	θ > 10 (rank : 352)	NC score	0.054184 (rank : 197)
Query Neighborhood Hits	263	Target Neighborhood Hits	1058	Shared Neighborhood Hits	81
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

SRC_MOUSE
θ value	θ > 10 (rank : 353)	NC score	0.051801 (rank : 215)
Query Neighborhood Hits	263	Target Neighborhood Hits	1033	Shared Neighborhood Hits	77
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

SRRM1_HUMAN
θ value	θ > 10 (rank : 354)	NC score	0.053199 (rank : 202)
Query Neighborhood Hits	263	Target Neighborhood Hits	690	Shared Neighborhood Hits	60
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

SRRM1_MOUSE
θ value	θ > 10 (rank : 355)	NC score	0.060636 (rank : 164)
Query Neighborhood Hits	263	Target Neighborhood Hits	966	Shared Neighborhood Hits	72
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

STAC3_HUMAN
θ value	θ > 10 (rank : 356)	NC score	0.063934 (rank : 141)
Query Neighborhood Hits	263	Target Neighborhood Hits	228	Shared Neighborhood Hits	47
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAC3_MOUSE
θ value	θ > 10 (rank : 357)	NC score	0.064321 (rank : 135)
Query Neighborhood Hits	263	Target Neighborhood Hits	232	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

STAM1_HUMAN
θ value	θ > 10 (rank : 358)	NC score	0.072273 (rank : 111)
Query Neighborhood Hits	263	Target Neighborhood Hits	271	Shared Neighborhood Hits	56
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM1_MOUSE
θ value	θ > 10 (rank : 359)	NC score	0.065943 (rank : 128)
Query Neighborhood Hits	263	Target Neighborhood Hits	273	Shared Neighborhood Hits	58
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

STAM2_HUMAN
θ value	θ > 10 (rank : 360)	NC score	0.060790 (rank : 163)
Query Neighborhood Hits	263	Target Neighborhood Hits	288	Shared Neighborhood Hits	56
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

STAM2_MOUSE
θ value	θ > 10 (rank : 361)	NC score	0.061984 (rank : 150)
Query Neighborhood Hits	263	Target Neighborhood Hits	285	Shared Neighborhood Hits	57
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

TARA_HUMAN
θ value	θ > 10 (rank : 362)	NC score	0.050282 (rank : 234)
Query Neighborhood Hits	263	Target Neighborhood Hits	1626	Shared Neighborhood Hits	89
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TARSH_HUMAN
θ value	θ > 10 (rank : 363)	NC score	0.083352 (rank : 72)
Query Neighborhood Hits	263	Target Neighborhood Hits	768	Shared Neighborhood Hits	90
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

TCGAP_HUMAN
θ value	θ > 10 (rank : 364)	NC score	0.058487 (rank : 174)
Query Neighborhood Hits	263	Target Neighborhood Hits	872	Shared Neighborhood Hits	102
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

TEX14_HUMAN
θ value	θ > 10 (rank : 365)	NC score	0.051280 (rank : 222)
Query Neighborhood Hits	263	Target Neighborhood Hits	1103	Shared Neighborhood Hits	70
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

TM108_MOUSE
θ value	θ > 10 (rank : 366)	NC score	0.050943 (rank : 226)
Query Neighborhood Hits	263	Target Neighborhood Hits	336	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BHE4, Q80WR9	Gene names	Tmem108
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

TPO_MOUSE
θ value	θ > 10 (rank : 367)	NC score	0.059231 (rank : 170)
Query Neighborhood Hits	263	Target Neighborhood Hits	258	Shared Neighborhood Hits	30
SwissProt Accessions	P40226	Gene names	Thpo
Domain Architecture
Description	Thrombopoietin precursor (Megakaryocyte colony-stimulating factor) (Myeloproliferative leukemia virus oncogene ligand) (C-mpl ligand) (ML) (Megakaryocyte growth and development factor) (MGDF).

TXK_MOUSE
θ value	θ > 10 (rank : 368)	NC score	0.050852 (rank : 227)
Query Neighborhood Hits	263	Target Neighborhood Hits	980	Shared Neighborhood Hits	76
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

TXND2_HUMAN
θ value	θ > 10 (rank : 369)	NC score	0.061567 (rank : 157)
Query Neighborhood Hits	263	Target Neighborhood Hits	793	Shared Neighborhood Hits	68
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

VINEX_HUMAN
θ value	θ > 10 (rank : 370)	NC score	0.097542 (rank : 44)
Query Neighborhood Hits	263	Target Neighborhood Hits	270	Shared Neighborhood Hits	57
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

VINEX_MOUSE
θ value	θ > 10 (rank : 371)	NC score	0.094237 (rank : 48)
Query Neighborhood Hits	263	Target Neighborhood Hits	286	Shared Neighborhood Hits	54
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

YES_HUMAN
θ value	θ > 10 (rank : 372)	NC score	0.055561 (rank : 191)
Query Neighborhood Hits	263	Target Neighborhood Hits	1059	Shared Neighborhood Hits	84
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

YES_MOUSE
θ value	θ > 10 (rank : 373)	NC score	0.055852 (rank : 187)
Query Neighborhood Hits	263	Target Neighborhood Hits	1052	Shared Neighborhood Hits	84
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

Hits sorted by NC score

SASH1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	263	Target Neighborhood Hits	263	Shared Neighborhood Hits	263
SwissProt Accessions	P59808	Gene names	Sash1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1.

SASH1_HUMAN
NC score	0.951963 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	263	Target Neighborhood Hits	292	Shared Neighborhood Hits	138
SwissProt Accessions	O94885, Q8TAI0, Q9H7R7	Gene names	SASH1, KIAA0790, PEPE1
Domain Architecture
Description	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat- containing protein).

SLY_HUMAN
NC score	0.836015 (rank : 3)	θ value	8.55514e-59 (rank : 4)
Query Neighborhood Hits	263	Target Neighborhood Hits	81	Shared Neighborhood Hits	57
SwissProt Accessions	O75995	Gene names	SLY, CXorf9
Domain Architecture
Description	SH3 protein expressed in lymphocytes homolog.

SLY_MOUSE
NC score	0.833082 (rank : 4)	θ value	1.55911e-60 (rank : 3)
Query Neighborhood Hits	263	Target Neighborhood Hits	108	Shared Neighborhood Hits	62
SwissProt Accessions	Q8K352, Q3TBX0, Q9DBV2	Gene names	Sly
Domain Architecture
Description	SH3 protein expressed in lymphocytes.

SAMN1_HUMAN
NC score	0.816015 (rank : 5)	θ value	3.48949e-44 (rank : 5)
Query Neighborhood Hits	263	Target Neighborhood Hits	74	Shared Neighborhood Hits	53
SwissProt Accessions	Q9NSI8, Q8NFF7, Q9C041	Gene names	SAMSN1, HACS1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1) (SH3-SAM adaptor protein) (Hematopoietic adaptor containing SH3 and SAM domains 1).

SAMN1_MOUSE
NC score	0.812510 (rank : 6)	θ value	6.58091e-43 (rank : 6)
Query Neighborhood Hits	263	Target Neighborhood Hits	69	Shared Neighborhood Hits	50
SwissProt Accessions	P57725, Q8C6S2	Gene names	Samsn1
Domain Architecture
Description	SAM domain-containing protein SAMSN-1 (SAM domain, SH3 domain and nuclear localization signals protein 1).

CD2AP_HUMAN
NC score	0.207151 (rank : 7)	θ value	0.000461057 (rank : 10)
Query Neighborhood Hits	263	Target Neighborhood Hits	315	Shared Neighborhood Hits	65
SwissProt Accessions	Q9Y5K6, Q9UG97	Gene names	CD2AP
Domain Architecture
Description	CD2-associated protein (Cas ligand with multiple SH3 domains) (Adapter protein CMS).

SH3K1_HUMAN
NC score	0.179441 (rank : 8)	θ value	0.0736092 (rank : 47)
Query Neighborhood Hits	263	Target Neighborhood Hits	341	Shared Neighborhood Hits	69
SwissProt Accessions	Q96B97, Q8IWX6, Q8IX98, Q96RN4, Q9NYR0	Gene names	SH3KBP1, CIN85
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (Cbl-interacting protein of 85 kDa) (Human Src-family kinase-binding protein 1) (HSB-1) (CD2-binding protein 3) (CD2BP3).

CRK_MOUSE
NC score	0.178001 (rank : 9)	θ value	0.0193708 (rank : 27)
Query Neighborhood Hits	263	Target Neighborhood Hits	314	Shared Neighborhood Hits	60
SwissProt Accessions	Q64010	Gene names	Crk, Crko
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

SH3K1_MOUSE
NC score	0.174349 (rank : 10)	θ value	0.163984 (rank : 58)
Query Neighborhood Hits	263	Target Neighborhood Hits	332	Shared Neighborhood Hits	67
SwissProt Accessions	Q8R550, Q8CAL8, Q8CEF6, Q8R545, Q8R546, Q8R547, Q8R548, Q8R549, Q8R551, Q9CTQ9, Q9DC14, Q9JKC3	Gene names	Sh3kbp1, Ruk, Seta
Domain Architecture
Description	SH3-domain kinase-binding protein 1 (SH3-containing, expressed in tumorigenic astrocytes) (Regulator of ubiquitous kinase) (Ruk).

CRK_HUMAN
NC score	0.172999 (rank : 11)	θ value	0.0252991 (rank : 29)
Query Neighborhood Hits	263	Target Neighborhood Hits	308	Shared Neighborhood Hits	61
SwissProt Accessions	P46108	Gene names	CRK
Domain Architecture
Description	Proto-oncogene C-crk (P38) (Adapter molecule crk).

CRKL_MOUSE
NC score	0.164945 (rank : 12)	θ value	0.0736092 (rank : 46)
Query Neighborhood Hits	263	Target Neighborhood Hits	307	Shared Neighborhood Hits	60
SwissProt Accessions	P47941, Q3TQ18, Q8BGC5	Gene names	Crkl, Crkol
Domain Architecture
Description	Crk-like protein.

CRKL_HUMAN
NC score	0.164856 (rank : 13)	θ value	0.0736092 (rank : 45)
Query Neighborhood Hits	263	Target Neighborhood Hits	313	Shared Neighborhood Hits	59
SwissProt Accessions	P46109	Gene names	CRKL
Domain Architecture
Description	Crk-like protein.

CD2AP_MOUSE
NC score	0.163571 (rank : 14)	θ value	1.06291 (rank : 97)
Query Neighborhood Hits	263	Target Neighborhood Hits	336	Shared Neighborhood Hits	70
SwissProt Accessions	Q9JLQ0, O88903, Q8K4Z1, Q8VCI9	Gene names	Cd2ap, Mets1
Domain Architecture
Description	CD2-associated protein (Mesenchyme-to-epithelium transition protein with SH3 domains 1) (METS-1).

ANKS1_MOUSE
NC score	0.150638 (rank : 15)	θ value	0.00020696 (rank : 8)
Query Neighborhood Hits	263	Target Neighborhood Hits	453	Shared Neighborhood Hits	51
SwissProt Accessions	P59672, Q6ZQG0	Gene names	Anks1a, Anks1, Kiaa0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A.

ANKS1_HUMAN
NC score	0.147775 (rank : 16)	θ value	1.43324e-05 (rank : 7)
Query Neighborhood Hits	263	Target Neighborhood Hits	438	Shared Neighborhood Hits	50
SwissProt Accessions	Q92625, Q5JYI9, Q5SYR2, Q86WQ7	Gene names	ANKS1A, ANKS1, KIAA0229
Domain Architecture
Description	Ankyrin repeat and SAM domain-containing protein 1A (Odin).

GRAP_HUMAN
NC score	0.141434 (rank : 17)	θ value	0.00298849 (rank : 15)
Query Neighborhood Hits	263	Target Neighborhood Hits	307	Shared Neighborhood Hits	60
SwissProt Accessions	Q13588	Gene names	GRAP
Domain Architecture
Description	GRB2-related adapter protein.

ARHG6_HUMAN
NC score	0.140785 (rank : 18)	θ value	0.125558 (rank : 51)
Query Neighborhood Hits	263	Target Neighborhood Hits	376	Shared Neighborhood Hits	58
SwissProt Accessions	Q15052, Q15396, Q5JQ66, Q86XH0	Gene names	ARHGEF6, COOL2, KIAA0006, PIXA
Domain Architecture
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6) (PAK-interacting exchange factor alpha) (Alpha-Pix) (COOL-2).

ARHG7_HUMAN
NC score	0.138125 (rank : 19)	θ value	0.0736092 (rank : 43)
Query Neighborhood Hits	263	Target Neighborhood Hits	347	Shared Neighborhood Hits	58
SwissProt Accessions	Q14155, Q6P9G3, Q6PII2, Q86W63, Q8N3M1	Gene names	ARHGEF7, COOL1, KIAA0142, P85SPR, PAK3BP, PIXB
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (COOL-1) (p85).

CSKI1_MOUSE
NC score	0.136758 (rank : 20)	θ value	0.00134147 (rank : 13)
Query Neighborhood Hits	263	Target Neighborhood Hits	1031	Shared Neighborhood Hits	122
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

CSKI1_HUMAN
NC score	0.136008 (rank : 21)	θ value	0.00134147 (rank : 12)
Query Neighborhood Hits	263	Target Neighborhood Hits	997	Shared Neighborhood Hits	120
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

ARHG7_MOUSE
NC score	0.134986 (rank : 22)	θ value	0.0563607 (rank : 38)
Query Neighborhood Hits	263	Target Neighborhood Hits	396	Shared Neighborhood Hits	60
SwissProt Accessions	Q9ES28, O08757, Q9ES27	Gene names	Arhgef7, Pak3bp
Domain Architecture
Description	Rho guanine nucleotide exchange factor 7 (PAK-interacting exchange factor beta) (Beta-Pix) (p85SPR).

ARHG6_MOUSE
NC score	0.134366 (rank : 23)	θ value	0.62314 (rank : 78)
Query Neighborhood Hits	263	Target Neighborhood Hits	394	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K4I3, Q8C9V4	Gene names	Arhgef6
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 6 (Rac/Cdc42 guanine nucleotide exchange factor 6).

CSKI2_MOUSE
NC score	0.128168 (rank : 24)	θ value	0.00869519 (rank : 22)
Query Neighborhood Hits	263	Target Neighborhood Hits	812	Shared Neighborhood Hits	103
SwissProt Accessions	Q8VHK1, Q6ZPX1, Q7TS77	Gene names	Caskin2, Kiaa1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

GRAP_MOUSE
NC score	0.125990 (rank : 25)	θ value	0.21417 (rank : 60)
Query Neighborhood Hits	263	Target Neighborhood Hits	309	Shared Neighborhood Hits	60
SwissProt Accessions	Q9CX99, Q3U545	Gene names	Grap
Domain Architecture	No domain graphic available
Description	GRB2-related adapter protein.

CSKI2_HUMAN
NC score	0.124195 (rank : 26)	θ value	0.00869519 (rank : 21)
Query Neighborhood Hits	263	Target Neighborhood Hits	747	Shared Neighborhood Hits	96
SwissProt Accessions	Q8WXE0, Q7LG69, Q9ULT1	Gene names	CASKIN2, KIAA1139
Domain Architecture	No domain graphic available
Description	Caskin-2.

NCK2_HUMAN
NC score	0.118674 (rank : 27)	θ value	0.365318 (rank : 68)
Query Neighborhood Hits	263	Target Neighborhood Hits	310	Shared Neighborhood Hits	57
SwissProt Accessions	O43639, Q9BWN9, Q9UIC3	Gene names	NCK2
Domain Architecture
Description	Cytoplasmic protein NCK2 (NCK adaptor protein 2) (SH2/SH3 adaptor protein NCK-beta) (Nck-2).

VAV_MOUSE
NC score	0.117626 (rank : 28)	θ value	0.125558 (rank : 54)
Query Neighborhood Hits	263	Target Neighborhood Hits	430	Shared Neighborhood Hits	60
SwissProt Accessions	P27870, Q8BTV7	Gene names	Vav1, Vav
Domain Architecture
Description	Proto-oncogene vav (p95vav).

VAV_HUMAN
NC score	0.117235 (rank : 29)	θ value	0.0961366 (rank : 50)
Query Neighborhood Hits	263	Target Neighborhood Hits	452	Shared Neighborhood Hits	58
SwissProt Accessions	P15498, Q15860	Gene names	VAV1, VAV
Domain Architecture
Description	Proto-oncogene vav.

STAC_HUMAN
NC score	0.115043 (rank : 30)	θ value	0.813845 (rank : 93)
Query Neighborhood Hits	263	Target Neighborhood Hits	276	Shared Neighborhood Hits	62
SwissProt Accessions	Q99469	Gene names	STAC
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

STAC_MOUSE
NC score	0.111838 (rank : 31)	θ value	1.38821 (rank : 118)
Query Neighborhood Hits	263	Target Neighborhood Hits	268	Shared Neighborhood Hits	59
SwissProt Accessions	P97306	Gene names	Stac
Domain Architecture
Description	SH3 and cysteine-rich domain-containing protein (SRC homology 3 and cysteine-rich domain protein).

SRBS1_HUMAN
NC score	0.109710 (rank : 32)	θ value	5.27518 (rank : 208)
Query Neighborhood Hits	263	Target Neighborhood Hits	396	Shared Neighborhood Hits	69
SwissProt Accessions	Q9BX66, Q7LBE5, Q8IVK0, Q8IVQ4, Q96KF3, Q96KF4, Q9BX64, Q9BX65, Q9P2Q0, Q9UFT2, Q9UHN7, Q9Y338	Gene names	SORBS1, KIAA1296, SH3D5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

SRBS1_MOUSE
NC score	0.108195 (rank : 33)	θ value	5.27518 (rank : 209)
Query Neighborhood Hits	263	Target Neighborhood Hits	409	Shared Neighborhood Hits	76
SwissProt Accessions	Q62417, Q80TF8, Q8BZI3, Q8K3Y2, Q921F8, Q9Z0Z8, Q9Z0Z9	Gene names	Sorbs1, Kiaa1296, Sh3d5
Domain Architecture	No domain graphic available
Description	Sorbin and SH3 domain-containing protein 1 (Ponsin) (c-Cbl-associated protein) (CAP) (SH3 domain protein 5) (SH3P12).

PRG4_HUMAN
NC score	0.104977 (rank : 34)	θ value	0.00035302 (rank : 9)
Query Neighborhood Hits	263	Target Neighborhood Hits	764	Shared Neighborhood Hits	57
SwissProt Accessions	Q92954, Q6DNC4, Q6DNC5, Q6ZMZ5, Q9BX49	Gene names	PRG4, MSF, SZP
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

GRAP2_MOUSE
NC score	0.103853 (rank : 35)	θ value	1.06291 (rank : 102)
Query Neighborhood Hits	263	Target Neighborhood Hits	297	Shared Neighborhood Hits	57
SwissProt Accessions	O89100	Gene names	Grap2, Gads, Grb2l, Grid, Mona
Domain Architecture
Description	GRB2-related adaptor protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (GRB-2-like protein) (GRB2L) (Hematopoietic cell-associated adaptor protein GrpL) (GRB-2-related monocytic adapter protein) (Monocytic adapter) (MONA) (Adapter protein GRID).

SH3G3_MOUSE
NC score	0.102926 (rank : 36)	θ value	2.36792 (rank : 151)
Query Neighborhood Hits	263	Target Neighborhood Hits	236	Shared Neighborhood Hits	56
SwissProt Accessions	Q62421	Gene names	Sh3gl3, Sh3d2c, Sh3d2c2
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (SH3p13).

VAV3_HUMAN
NC score	0.102408 (rank : 37)	θ value	1.06291 (rank : 109)
Query Neighborhood Hits	263	Target Neighborhood Hits	398	Shared Neighborhood Hits	57
SwissProt Accessions	Q9UKW4, O95230, Q9Y5X8	Gene names	VAV3
Domain Architecture
Description	Protein vav-3.

EPHB6_MOUSE
NC score	0.101717 (rank : 38)	θ value	0.00102713 (rank : 11)
Query Neighborhood Hits	263	Target Neighborhood Hits	906	Shared Neighborhood Hits	55
SwissProt Accessions	O08644, Q8BN76, Q8K0A9	Gene names	Ephb6, Cekl
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (MEP).

NACAM_MOUSE
NC score	0.100076 (rank : 39)	θ value	0.0563607 (rank : 41)
Query Neighborhood Hits	263	Target Neighborhood Hits	1866	Shared Neighborhood Hits	110
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

EPHB6_HUMAN
NC score	0.099385 (rank : 40)	θ value	0.0148317 (rank : 26)
Query Neighborhood Hits	263	Target Neighborhood Hits	912	Shared Neighborhood Hits	53
SwissProt Accessions	O15197	Gene names	EPHB6
Domain Architecture
Description	Ephrin type-B receptor 6 precursor (Tyrosine-protein kinase-defective receptor EPH-6) (HEP).

VAV3_MOUSE
NC score	0.099211 (rank : 41)	θ value	1.81305 (rank : 131)
Query Neighborhood Hits	263	Target Neighborhood Hits	404	Shared Neighborhood Hits	55
SwissProt Accessions	Q9R0C8, Q7TS85	Gene names	Vav3
Domain Architecture
Description	Protein vav-3.

SRRM2_MOUSE
NC score	0.099063 (rank : 42)	θ value	0.0431538 (rank : 37)
Query Neighborhood Hits	263	Target Neighborhood Hits	1470	Shared Neighborhood Hits	97
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

ABI2_HUMAN
NC score	0.097893 (rank : 43)	θ value	6.88961 (rank : 213)
Query Neighborhood Hits	263	Target Neighborhood Hits	350	Shared Neighborhood Hits	75
SwissProt Accessions	Q9NYB9, Q13147, Q13249, Q13801, Q9BV70	Gene names	ABI2, ARGBPIA
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2) (Abl-binding protein 3) (AblBP3) (Arg-binding protein 1) (ArgBP1).

VINEX_HUMAN
NC score	0.097542 (rank : 44)	θ value	θ > 10 (rank : 370)
Query Neighborhood Hits	263	Target Neighborhood Hits	270	Shared Neighborhood Hits	57
SwissProt Accessions	O60504, Q9UQE4	Gene names	SORBS3, SCAM1
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1).

ITSN1_HUMAN
NC score	0.097065 (rank : 45)	θ value	0.0563607 (rank : 39)
Query Neighborhood Hits	263	Target Neighborhood Hits	1757	Shared Neighborhood Hits	113
SwissProt Accessions	Q15811, O95216, Q9UET5, Q9UK60, Q9UNK1, Q9UNK2, Q9UQ92	Gene names	ITSN1, ITSN, SH3D1A
Domain Architecture
Description	Intersectin-1 (SH3 domain-containing protein 1A) (SH3P17).

GRAP2_HUMAN
NC score	0.096310 (rank : 46)	θ value	2.36792 (rank : 140)
Query Neighborhood Hits	263	Target Neighborhood Hits	304	Shared Neighborhood Hits	58
SwissProt Accessions	O75791, O43726	Gene names	GRAP2, GADS, GRB2L, GRID
Domain Architecture
Description	GRB2-related adapter protein 2 (GADS protein) (Growth factor receptor- binding protein) (GRBLG) (Grf40 adapter protein) (Grf-40) (GRB-2-like protein) (GRB2L) (GRBX) (P38) (Hematopoietic cell-associated adapter protein GrpL) (Adapter protein GRID) (SH3-SH2-SH3 adapter Mona).

PRG4_MOUSE
NC score	0.095824 (rank : 47)	θ value	0.00390308 (rank : 19)
Query Neighborhood Hits	263	Target Neighborhood Hits	624	Shared Neighborhood Hits	57
SwissProt Accessions	Q9JM99, Q3UEL1, Q3V198	Gene names	Prg4, Msf, Szp
Domain Architecture	No domain graphic available
Description	Proteoglycan-4 precursor (Lubricin) (Megakaryocyte-stimulating factor) (Superficial zone proteoglycan) [Contains: Proteoglycan-4 C-terminal part].

VINEX_MOUSE
NC score	0.094237 (rank : 48)	θ value	θ > 10 (rank : 371)
Query Neighborhood Hits	263	Target Neighborhood Hits	286	Shared Neighborhood Hits	54
SwissProt Accessions	Q9R1Z8, Q62423	Gene names	Sorbs3, Scam1, Sh3d4
Domain Architecture
Description	Vinexin (Sorbin and SH3 domain-containing protein 3) (SH3-containing adapter molecule 1) (SCAM-1) (SH3 domain-containing protein SH3P3).

SRRM2_HUMAN
NC score	0.093333 (rank : 49)	θ value	0.0193708 (rank : 28)
Query Neighborhood Hits	263	Target Neighborhood Hits	1296	Shared Neighborhood Hits	85
SwissProt Accessions	Q9UQ35, O15038, O94803, Q6NSL3, Q6PIM3, Q6PK40, Q8IW17, Q96GY7, Q9P0G1, Q9UHA8, Q9UQ36, Q9UQ37, Q9UQ38, Q9UQ40	Gene names	SRRM2, KIAA0324, SRL300, SRM300
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2 (Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa) (Ser/Arg- related nuclear matrix protein) (SR-related nuclear matrix protein of 300 kDa) (Splicing coactivator subunit SRm300) (300 kDa nuclear matrix antigen).

VAV2_HUMAN
NC score	0.091363 (rank : 50)	θ value	3.0926 (rank : 177)
Query Neighborhood Hits	263	Target Neighborhood Hits	453	Shared Neighborhood Hits	55
SwissProt Accessions	P52735	Gene names	VAV2
Domain Architecture
Description	Protein vav-2.

VAV2_MOUSE
NC score	0.091338 (rank : 51)	θ value	2.36792 (rank : 155)
Query Neighborhood Hits	263	Target Neighborhood Hits	456	Shared Neighborhood Hits	56
SwissProt Accessions	Q60992	Gene names	Vav2
Domain Architecture
Description	Protein vav-2.

ABI2_MOUSE
NC score	0.090783 (rank : 52)	θ value	5.27518 (rank : 194)
Query Neighborhood Hits	263	Target Neighborhood Hits	266	Shared Neighborhood Hits	58
SwissProt Accessions	P62484, Q6PHU3	Gene names	Abi2
Domain Architecture	No domain graphic available
Description	Abl interactor 2 (Abelson interactor 2) (Abi-2).

SH3G2_MOUSE
NC score	0.090293 (rank : 53)	θ value	8.99809 (rank : 256)
Query Neighborhood Hits	263	Target Neighborhood Hits	319	Shared Neighborhood Hits	57
SwissProt Accessions	Q62420	Gene names	Sh3gl2, Sh3d2a
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (SH3p4).

NCK1_HUMAN
NC score	0.090180 (rank : 54)	θ value	6.88961 (rank : 226)
Query Neighborhood Hits	263	Target Neighborhood Hits	312	Shared Neighborhood Hits	51
SwissProt Accessions	P16333	Gene names	NCK1, NCK
Domain Architecture
Description	Cytoplasmic protein NCK1 (NCK adaptor protein 1) (SH2/SH3 adaptor protein NCK-alpha).

MDC1_HUMAN
NC score	0.089983 (rank : 55)	θ value	0.62314 (rank : 82)
Query Neighborhood Hits	263	Target Neighborhood Hits	1446	Shared Neighborhood Hits	106
SwissProt Accessions	Q14676, Q5JP55, Q5JP56, Q5ST83, Q68CQ3, Q86Z06, Q96QC2	Gene names	MDC1, KIAA0170, NFBD1
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1).

EPHA6_MOUSE
NC score	0.089739 (rank : 56)	θ value	0.0330416 (rank : 32)
Query Neighborhood Hits	263	Target Neighborhood Hits	946	Shared Neighborhood Hits	54
SwissProt Accessions	Q62413, Q8CCN2	Gene names	Epha6, Ehk-2, Ehk2
Domain Architecture
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

NCF1_MOUSE
NC score	0.089722 (rank : 57)	θ value	3.0926 (rank : 165)
Query Neighborhood Hits	263	Target Neighborhood Hits	198	Shared Neighborhood Hits	49
SwissProt Accessions	Q09014, O70144, Q9JI34	Gene names	Ncf1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K).

EPHA6_HUMAN
NC score	0.089109 (rank : 58)	θ value	0.125558 (rank : 52)
Query Neighborhood Hits	263	Target Neighborhood Hits	959	Shared Neighborhood Hits	54
SwissProt Accessions	Q9UF33	Gene names	EPHA6, EHK2
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 6 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-2) (EPH homology kinase 2).

ITSN1_MOUSE
NC score	0.088097 (rank : 59)	θ value	0.813845 (rank : 87)
Query Neighborhood Hits	263	Target Neighborhood Hits	1669	Shared Neighborhood Hits	112
SwissProt Accessions	Q9Z0R4, Q9R143	Gene names	Itsn1, Ese1, Itsn
Domain Architecture
Description	Intersectin-1 (EH and SH3 domains protein 1).

EPHA4_MOUSE
NC score	0.087486 (rank : 60)	θ value	0.00390308 (rank : 18)
Query Neighborhood Hits	263	Target Neighborhood Hits	982	Shared Neighborhood Hits	52
SwissProt Accessions	Q03137	Gene names	Epha4, Sek, Sek1
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (MPK-3).

EPHA4_HUMAN
NC score	0.086547 (rank : 61)	θ value	0.0113563 (rank : 23)
Query Neighborhood Hits	263	Target Neighborhood Hits	975	Shared Neighborhood Hits	52
SwissProt Accessions	P54764	Gene names	EPHA4, HEK8, SEK
Domain Architecture
Description	Ephrin type-A receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor SEK) (Receptor protein-tyrosine kinase HEK8).

OSTF1_MOUSE
NC score	0.085936 (rank : 62)	θ value	θ > 10 (rank : 335)
Query Neighborhood Hits	263	Target Neighborhood Hits	467	Shared Neighborhood Hits	62
SwissProt Accessions	Q62422, Q3UF05	Gene names	Ostf1, Sh3d3, Sh3p2
Domain Architecture
Description	Osteoclast-stimulating factor 1 (SH3 domain protein 3).

EPHA5_HUMAN
NC score	0.085366 (rank : 63)	θ value	0.00509761 (rank : 20)
Query Neighborhood Hits	263	Target Neighborhood Hits	1009	Shared Neighborhood Hits	54
SwissProt Accessions	P54756	Gene names	EPHA5, EHK1, HEK7
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Receptor protein- tyrosine kinase HEK7).

GSCR1_HUMAN
NC score	0.085248 (rank : 64)	θ value	0.21417 (rank : 61)
Query Neighborhood Hits	263	Target Neighborhood Hits	674	Shared Neighborhood Hits	62
SwissProt Accessions	Q9NZM4	Gene names	GLTSCR1
Domain Architecture	No domain graphic available
Description	Glioma tumor suppressor candidate region gene 1 protein.

EPHA7_HUMAN
NC score	0.085168 (rank : 65)	θ value	0.0148317 (rank : 25)
Query Neighborhood Hits	263	Target Neighborhood Hits	1053	Shared Neighborhood Hits	53
SwissProt Accessions	Q15375, Q59G40, Q5VTU0, Q8N368, Q9H124	Gene names	EPHA7, EHK3, HEK11
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Receptor protein- tyrosine kinase HEK11).

EPHA7_MOUSE
NC score	0.084740 (rank : 66)	θ value	0.0252991 (rank : 30)
Query Neighborhood Hits	263	Target Neighborhood Hits	1025	Shared Neighborhood Hits	53
SwissProt Accessions	Q61772, Q61505, Q61773, Q61774	Gene names	Epha7, Ebk, Ehk3, Mdk1
Domain Architecture
Description	Ephrin type-A receptor 7 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-3) (EPH homology kinase 3) (Embryonic brain kinase) (EBK) (Developmental kinase 1) (MDK-1).

EPHAA_HUMAN
NC score	0.084723 (rank : 67)	θ value	4.03905 (rank : 186)
Query Neighborhood Hits	263	Target Neighborhood Hits	960	Shared Neighborhood Hits	51
SwissProt Accessions	Q5JZY3, Q6NW42	Gene names	EPHA10
Domain Architecture	No domain graphic available
Description	Ephrin type-A receptor 10 precursor (EC 2.7.10.1).

OSTF1_HUMAN
NC score	0.084335 (rank : 68)	θ value	θ > 10 (rank : 334)
Query Neighborhood Hits	263	Target Neighborhood Hits	466	Shared Neighborhood Hits	61
SwissProt Accessions	Q92882, Q5W126, Q96IJ4	Gene names	OSTF1
Domain Architecture
Description	Osteoclast-stimulating factor 1.

NPHP1_MOUSE
NC score	0.084264 (rank : 69)	θ value	2.36792 (rank : 146)
Query Neighborhood Hits	263	Target Neighborhood Hits	267	Shared Neighborhood Hits	51
SwissProt Accessions	Q9QY53, Q9D7G8, Q9QZP0, Q9WUZ2	Gene names	Nphp1, Nph1
Domain Architecture
Description	Nephrocystin-1.

MYO1E_HUMAN
NC score	0.084064 (rank : 70)	θ value	0.00134147 (rank : 14)
Query Neighborhood Hits	263	Target Neighborhood Hits	293	Shared Neighborhood Hits	60
SwissProt Accessions	Q12965, Q14778	Gene names	MYO1E, MYO1C
Domain Architecture
Description	Myosin Ie (Myosin Ic).

SHAN2_MOUSE
NC score	0.083634 (rank : 71)	θ value	5.27518 (rank : 207)
Query Neighborhood Hits	263	Target Neighborhood Hits	446	Shared Neighborhood Hits	95
SwissProt Accessions	Q80Z38, Q3UTK4, Q5DU07	Gene names	Shank2, Kiaa1022
Domain Architecture	No domain graphic available
Description	SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin- binding protein 1) (CortBP1).

TARSH_HUMAN
NC score	0.083352 (rank : 72)	θ value	θ > 10 (rank : 363)
Query Neighborhood Hits	263	Target Neighborhood Hits	768	Shared Neighborhood Hits	90
SwissProt Accessions	Q7Z7G0, Q6ZW20, Q6ZW22, Q9C082, Q9UFI6	Gene names	ABI3BP, NESHBP, TARSH
Domain Architecture	No domain graphic available
Description	Target of Nesh-SH3 precursor (Tarsh) (Nesh-binding protein) (NeshBP) (ABI gene family member 3-binding protein).

HCLS1_HUMAN
NC score	0.082634 (rank : 73)	θ value	θ > 10 (rank : 309)
Query Neighborhood Hits	263	Target Neighborhood Hits	358	Shared Neighborhood Hits	78
SwissProt Accessions	P14317	Gene names	HCLS1, HS1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1) (p75).

SET1A_HUMAN
NC score	0.082577 (rank : 74)	θ value	0.00298849 (rank : 17)
Query Neighborhood Hits	263	Target Neighborhood Hits	690	Shared Neighborhood Hits	54
SwissProt Accessions	O15047, Q6PIF3, Q8TAJ6	Gene names	SETD1A, KIAA0339, SET1
Domain Architecture	No domain graphic available
Description	Histone-lysine N-methyltransferase, H3 lysine-4 specific SET1 (EC 2.1.1.43) (Set1/Ash2 histone methyltransferase complex subunit SET1) (SET-domain-containing protein 1A).

GRB2_HUMAN
NC score	0.082492 (rank : 75)	θ value	θ > 10 (rank : 305)
Query Neighborhood Hits	263	Target Neighborhood Hits	310	Shared Neighborhood Hits	52
SwissProt Accessions	P62993, P29354, Q14450, Q63057, Q63059	Gene names	GRB2, ASH
Domain Architecture	No domain graphic available
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) (Protein Ash).

EPHB3_HUMAN
NC score	0.082383 (rank : 76)	θ value	1.06291 (rank : 101)
Query Neighborhood Hits	263	Target Neighborhood Hits	996	Shared Neighborhood Hits	53
SwissProt Accessions	P54753, Q7Z740	Gene names	EPHB3, ETK2, HEK2
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HEK-2).

GRB2_MOUSE
NC score	0.082308 (rank : 77)	θ value	θ > 10 (rank : 306)
Query Neighborhood Hits	263	Target Neighborhood Hits	312	Shared Neighborhood Hits	52
SwissProt Accessions	Q60631, Q61240	Gene names	Grb2
Domain Architecture
Description	Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2).

EPHB1_HUMAN
NC score	0.081935 (rank : 78)	θ value	0.0961366 (rank : 48)
Query Neighborhood Hits	263	Target Neighborhood Hits	988	Shared Neighborhood Hits	53
SwissProt Accessions	P54762, O43569, O95142, O95143	Gene names	EPHB1, EPHT2, NET
Domain Architecture
Description	Ephrin type-B receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-2) (NET) (HEK6) (ELK).

EPHA1_MOUSE
NC score	0.081852 (rank : 79)	θ value	0.279714 (rank : 65)
Query Neighborhood Hits	263	Target Neighborhood Hits	958	Shared Neighborhood Hits	53
SwissProt Accessions	Q60750, Q8CED9, Q9ESJ2	Gene names	Epha1, Esk
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ESK).

PRR12_HUMAN
NC score	0.081641 (rank : 80)	θ value	0.62314 (rank : 85)
Query Neighborhood Hits	263	Target Neighborhood Hits	460	Shared Neighborhood Hits	50
SwissProt Accessions	Q9ULL5, Q8N4J6	Gene names	PRR12, KIAA1205
Domain Architecture	No domain graphic available
Description	Proline-rich protein 12.

NCF2_HUMAN
NC score	0.081561 (rank : 81)	θ value	θ > 10 (rank : 327)
Query Neighborhood Hits	263	Target Neighborhood Hits	229	Shared Neighborhood Hits	50
SwissProt Accessions	P19878, Q2PP06, Q8NFC7, Q9BV51	Gene names	NCF2
Domain Architecture
Description	Neutrophil cytosol factor 2 (NCF-2) (Neutrophil NADPH oxidase factor 2) (67 kDa neutrophil oxidase factor) (p67-phox) (NOXA2).

ITSN2_HUMAN
NC score	0.081415 (rank : 82)	θ value	2.36792 (rank : 143)
Query Neighborhood Hits	263	Target Neighborhood Hits	1173	Shared Neighborhood Hits	80
SwissProt Accessions	Q9NZM3, O95062, Q15812, Q9HAK4, Q9NXE6, Q9NYG0, Q9NZM2, Q9ULG4	Gene names	ITSN2, KIAA1256, SH3D1B, SWAP
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein).

EPHB4_MOUSE
NC score	0.081046 (rank : 83)	θ value	0.163984 (rank : 56)
Query Neighborhood Hits	263	Target Neighborhood Hits	1013	Shared Neighborhood Hits	53
SwissProt Accessions	P54761, Q60627	Gene names	Ephb4, Htk, Mdk2, Myk1
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-2) (Developmental kinase 2) (Tyrosine kinase MYK- 1).

ITSN2_MOUSE
NC score	0.080605 (rank : 84)	θ value	1.06291 (rank : 103)
Query Neighborhood Hits	263	Target Neighborhood Hits	1371	Shared Neighborhood Hits	87
SwissProt Accessions	Q9Z0R6, Q9Z0R5	Gene names	Itsn2, Ese2, Sh3d1B
Domain Architecture
Description	Intersectin-2 (SH3 domain-containing protein 1B) (EH and SH3 domains protein 2) (EH domain and SH3 domain regulator of endocytosis 2).

EPHA2_MOUSE
NC score	0.080351 (rank : 85)	θ value	1.81305 (rank : 122)
Query Neighborhood Hits	263	Target Neighborhood Hits	1020	Shared Neighborhood Hits	56
SwissProt Accessions	Q03145, Q60633, Q62212	Gene names	Epha2, Eck, Sek2
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase) (MPK-5) (SEK-2).

NCF1_HUMAN
NC score	0.080135 (rank : 86)	θ value	θ > 10 (rank : 326)
Query Neighborhood Hits	263	Target Neighborhood Hits	198	Shared Neighborhood Hits	48
SwissProt Accessions	P14598, O43842, Q2PP07, Q9BU90, Q9BXI7, Q9BXI8, Q9UDV9, Q9UMU2	Gene names	NCF1
Domain Architecture
Description	Neutrophil cytosol factor 1 (NCF-1) (Neutrophil NADPH oxidase factor 1) (47 kDa neutrophil oxidase factor) (p47-phox) (NCF-47K) (47 kDa autosomal chronic granulomatous disease protein) (NOXO2).

EPHB4_HUMAN
NC score	0.080106 (rank : 87)	θ value	0.279714 (rank : 67)
Query Neighborhood Hits	263	Target Neighborhood Hits	1056	Shared Neighborhood Hits	53
SwissProt Accessions	P54760, Q9BTA5, Q9BXP0	Gene names	EPHB4, HTK
Domain Architecture
Description	Ephrin type-B receptor 4 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor HTK).

EPHB3_MOUSE
NC score	0.080032 (rank : 88)	θ value	2.36792 (rank : 139)
Query Neighborhood Hits	263	Target Neighborhood Hits	996	Shared Neighborhood Hits	53
SwissProt Accessions	P54754, Q62214	Gene names	Ephb3, Etk2, Mdk5, Sek4
Domain Architecture
Description	Ephrin type-B receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor MDK-5) (Developmental kinase 5) (SEK-4).

EPHB2_HUMAN
NC score	0.079994 (rank : 89)	θ value	1.81305 (rank : 123)
Query Neighborhood Hits	263	Target Neighborhood Hits	983	Shared Neighborhood Hits	53
SwissProt Accessions	P29323, O43477, Q5T0U6, Q5T0U7, Q5T0U8	Gene names	EPHB2, DRT, EPTH3, ERK, HEK5
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (DRT) (Receptor protein-tyrosine kinase HEK5) (ERK) (NY-REN-47 antigen).

EPHA1_HUMAN
NC score	0.079846 (rank : 90)	θ value	0.62314 (rank : 80)
Query Neighborhood Hits	263	Target Neighborhood Hits	997	Shared Neighborhood Hits	52
SwissProt Accessions	P21709, Q15405	Gene names	EPHA1, EPH, EPHT, EPHT1
Domain Architecture
Description	Ephrin type-A receptor 1 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH).

TRDN_HUMAN
NC score	0.079711 (rank : 91)	θ value	0.125558 (rank : 53)
Query Neighborhood Hits	263	Target Neighborhood Hits	542	Shared Neighborhood Hits	37
SwissProt Accessions	Q13061	Gene names	TRDN
Domain Architecture
Description	Triadin.

EPHB2_MOUSE
NC score	0.079548 (rank : 92)	θ value	1.81305 (rank : 124)
Query Neighborhood Hits	263	Target Neighborhood Hits	982	Shared Neighborhood Hits	53
SwissProt Accessions	P54763, Q62213, Q9QVY4	Gene names	Ephb2, Epth3, Nuk, Sek3
Domain Architecture
Description	Ephrin type-B receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EPH-3) (Neural kinase) (Nuk receptor tyrosine kinase) (SEK-3).

EPHA8_MOUSE
NC score	0.079528 (rank : 93)	θ value	4.03905 (rank : 185)
Query Neighborhood Hits	263	Target Neighborhood Hits	969	Shared Neighborhood Hits	53
SwissProt Accessions	O09127	Gene names	Epha8, Eek
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase).

EPHA2_HUMAN
NC score	0.079032 (rank : 94)	θ value	3.0926 (rank : 160)
Query Neighborhood Hits	263	Target Neighborhood Hits	1021	Shared Neighborhood Hits	58
SwissProt Accessions	P29317	Gene names	EPHA2, ECK
Domain Architecture
Description	Ephrin type-A receptor 2 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ECK) (Epithelial cell kinase).

EPHA8_HUMAN
NC score	0.078503 (rank : 95)	θ value	4.03905 (rank : 184)
Query Neighborhood Hits	263	Target Neighborhood Hits	956	Shared Neighborhood Hits	52
SwissProt Accessions	P29322, Q9NUA9, Q9P269	Gene names	EPHA8, EEK, KIAA1459
Domain Architecture
Description	Ephrin type-A receptor 8 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EEK) (EPH- and ELK-related kinase) (HEK3).

SON_HUMAN
NC score	0.078462 (rank : 96)	θ value	0.163984 (rank : 59)
Query Neighborhood Hits	263	Target Neighborhood Hits	1568	Shared Neighborhood Hits	93
SwissProt Accessions	P18583, O14487, O95981, Q14120, Q9H7B1, Q9P070, Q9P072, Q9UKP9, Q9UPY0	Gene names	SON, C21orf50, DBP5, KIAA1019, NREBP
Domain Architecture
Description	SON protein (SON3) (Negative regulatory element-binding protein) (NRE- binding protein) (DBP-5) (Bax antagonist selected in saccharomyces 1) (BASS1).

FA47A_HUMAN
NC score	0.078211 (rank : 97)	θ value	θ > 10 (rank : 299)
Query Neighborhood Hits	263	Target Neighborhood Hits	451	Shared Neighborhood Hits	62
SwissProt Accessions	Q5JRC9, Q8TAA0	Gene names	FAM47A
Domain Architecture	No domain graphic available
Description	Protein FAM47A.

SH3G2_HUMAN
NC score	0.077978 (rank : 98)	θ value	θ > 10 (rank : 345)
Query Neighborhood Hits	263	Target Neighborhood Hits	324	Shared Neighborhood Hits	53
SwissProt Accessions	Q99962, Q9NQK5	Gene names	SH3GL2, CNSA2, SH3D2A
Domain Architecture
Description	SH3-containing GRB2-like protein 2 (EC 2.3.1.-) (Endophilin-1) (Endophilin-A1) (SH3 domain protein 2A) (EEN-B1).

SH3G1_MOUSE
NC score	0.077901 (rank : 99)	θ value	8.99809 (rank : 255)
Query Neighborhood Hits	263	Target Neighborhood Hits	291	Shared Neighborhood Hits	58
SwissProt Accessions	Q62419	Gene names	Sh3gl1, Sh3d2b
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (SH3p8).

MDC1_MOUSE
NC score	0.077245 (rank : 100)	θ value	θ > 10 (rank : 323)
Query Neighborhood Hits	263	Target Neighborhood Hits	998	Shared Neighborhood Hits	79
SwissProt Accessions	Q5PSV9, Q5U4D3, Q6ZQH7	Gene names	Mdc1, Kiaa0170
Domain Architecture	No domain graphic available
Description	Mediator of DNA damage checkpoint protein 1.

CEND1_HUMAN
NC score	0.077073 (rank : 101)	θ value	0.0736092 (rank : 44)
Query Neighborhood Hits	263	Target Neighborhood Hits	284	Shared Neighborhood Hits	43
SwissProt Accessions	Q8WZ64, Q4W5D2, Q7Z2L5, Q96L70, Q96P49, Q9Y4E4	Gene names	CENTD1, ARAP2, KIAA0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 2) (PARX protein).

SH3G1_HUMAN
NC score	0.076003 (rank : 102)	θ value	8.99809 (rank : 254)
Query Neighborhood Hits	263	Target Neighborhood Hits	307	Shared Neighborhood Hits	59
SwissProt Accessions	Q99961, Q99668	Gene names	SH3GL1, CNSA1, SH3D2B
Domain Architecture
Description	SH3-containing GRB2-like protein 1 (Endophilin-2) (Endophilin-A2) (SH3 domain protein 2B) (Extra eleven-nineteen leukemia fusion gene) (EEN) (EEN fusion partner of MLL).

OGFR_HUMAN
NC score	0.075608 (rank : 103)	θ value	1.06291 (rank : 106)
Query Neighborhood Hits	263	Target Neighborhood Hits	1582	Shared Neighborhood Hits	95
SwissProt Accessions	Q9NZT2, O96029, Q4VXW5, Q96CM2, Q9BQW1, Q9H4H0, Q9H7J5, Q9NZT3, Q9NZT4	Gene names	OGFR
Domain Architecture
Description	Opioid growth factor receptor (OGFr) (Zeta-type opioid receptor) (7-60 protein).

MUC1_HUMAN
NC score	0.075234 (rank : 104)	θ value	0.0252991 (rank : 31)
Query Neighborhood Hits	263	Target Neighborhood Hits	975	Shared Neighborhood Hits	69
SwissProt Accessions	P15941, P13931, P15942, P17626, Q14128, Q14876, Q16437, Q16442, Q16615, Q9BXA4, Q9UE75, Q9UE76, Q9UQL1, Q9Y4J2	Gene names	MUC1
Domain Architecture
Description	Mucin-1 precursor (MUC-1) (Polymorphic epithelial mucin) (PEM) (PEMT) (Episialin) (Tumor-associated mucin) (Carcinoma-associated mucin) (Tumor-associated epithelial membrane antigen) (EMA) (H23AG) (Peanut- reactive urinary mucin) (PUM) (Breast carcinoma-associated antigen DF3) (CD227 antigen).

SFR15_HUMAN
NC score	0.074717 (rank : 105)	θ value	0.0431538 (rank : 36)
Query Neighborhood Hits	263	Target Neighborhood Hits	368	Shared Neighborhood Hits	31
SwissProt Accessions	O95104, Q6P1M5, Q8N3I8, Q9UFM1, Q9ULP8	Gene names	SFRS15, KIAA1172
Domain Architecture	No domain graphic available
Description	Splicing factor, arginine/serine-rich 15 (CTD-binding SR-like protein RA4).

WASIP_HUMAN
NC score	0.074068 (rank : 106)	θ value	8.99809 (rank : 261)
Query Neighborhood Hits	263	Target Neighborhood Hits	458	Shared Neighborhood Hits	53
SwissProt Accessions	O43516, Q15220, Q6MZU9, Q9BU37, Q9UNP1	Gene names	WASPIP, WIP
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein-interacting protein (WASP-interacting protein) (PRPL-2 protein).

DNMBP_MOUSE
NC score	0.073547 (rank : 107)	θ value	θ > 10 (rank : 294)
Query Neighborhood Hits	263	Target Neighborhood Hits	435	Shared Neighborhood Hits	67
SwissProt Accessions	Q6TXD4, Q6ZQ05, Q8CEW8, Q8R0Y2	Gene names	Dnmbp, Kiaa1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

FA47B_HUMAN
NC score	0.072753 (rank : 108)	θ value	0.47712 (rank : 72)
Query Neighborhood Hits	263	Target Neighborhood Hits	431	Shared Neighborhood Hits	53
SwissProt Accessions	Q8NA70, Q5JQN5, Q6PIG3	Gene names	FAM47B
Domain Architecture	No domain graphic available
Description	Protein FAM47B.

BSN_MOUSE
NC score	0.072520 (rank : 109)	θ value	0.62314 (rank : 79)
Query Neighborhood Hits	263	Target Neighborhood Hits	2057	Shared Neighborhood Hits	109
SwissProt Accessions	O88737, Q6ZQB5	Gene names	Bsn, Kiaa0434
Domain Architecture	No domain graphic available
Description	Protein bassoon.

PCLO_HUMAN
NC score	0.072418 (rank : 110)	θ value	0.47712 (rank : 75)
Query Neighborhood Hits	263	Target Neighborhood Hits	2046	Shared Neighborhood Hits	122
SwissProt Accessions	Q9Y6V0, O43373, O60305, Q9BVC8, Q9UIV2, Q9Y6U9	Gene names	PCLO, ACZ, KIAA0559
Domain Architecture
Description	Protein piccolo (Aczonin).

STAM1_HUMAN
NC score	0.072273 (rank : 111)	θ value	θ > 10 (rank : 358)
Query Neighborhood Hits	263	Target Neighborhood Hits	271	Shared Neighborhood Hits	56
SwissProt Accessions	Q92783, Q8N6D9	Gene names	STAM, STAM1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

EPHA5_MOUSE
NC score	0.071945 (rank : 112)	θ value	0.279714 (rank : 66)
Query Neighborhood Hits	263	Target Neighborhood Hits	950	Shared Neighborhood Hits	52
SwissProt Accessions	Q60629	Gene names	Epha5, Bsk, Cek7, Ehk1
Domain Architecture
Description	Ephrin type-A receptor 5 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor EHK-1) (EPH homology kinase 1) (Brain-specific kinase) (CEK-7).

SH3G3_HUMAN
NC score	0.070873 (rank : 113)	θ value	θ > 10 (rank : 346)
Query Neighborhood Hits	263	Target Neighborhood Hits	222	Shared Neighborhood Hits	54
SwissProt Accessions	Q99963, O43553, O43554	Gene names	SH3GL3, CNSA3, SH3D2C
Domain Architecture
Description	SH3-containing GRB2-like protein 3 (Endophilin-3) (Endophilin-A3) (SH3 domain protein 2C) (EEN-B2).

MAP1B_HUMAN
NC score	0.070630 (rank : 114)	θ value	0.0330416 (rank : 33)
Query Neighborhood Hits	263	Target Neighborhood Hits	903	Shared Neighborhood Hits	57
SwissProt Accessions	P46821	Gene names	MAP1B
Domain Architecture	No domain graphic available
Description	Microtubule-associated protein 1B (MAP 1B) [Contains: MAP1 light chain LC1].

RIN3_HUMAN
NC score	0.070542 (rank : 115)	θ value	0.0563607 (rank : 42)
Query Neighborhood Hits	263	Target Neighborhood Hits	227	Shared Neighborhood Hits	31
SwissProt Accessions	Q8TB24, Q8NF30, Q8TEE8, Q8WYP4, Q9H6A5, Q9HAG1	Gene names	RIN3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

HCLS1_MOUSE
NC score	0.070224 (rank : 116)	θ value	θ > 10 (rank : 310)
Query Neighborhood Hits	263	Target Neighborhood Hits	329	Shared Neighborhood Hits	65
SwissProt Accessions	P49710	Gene names	Hcls1, Hs1
Domain Architecture
Description	Hematopoietic lineage cell-specific protein (Hematopoietic cell- specific LYN substrate 1) (LckBP1).

EPHA3_MOUSE
NC score	0.069737 (rank : 117)	θ value	θ > 10 (rank : 298)
Query Neighborhood Hits	263	Target Neighborhood Hits	1009	Shared Neighborhood Hits	44
SwissProt Accessions	P29319	Gene names	Epha3, Etk1, Mek4, Tyro4
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (MEK4).

SHAN1_HUMAN
NC score	0.069557 (rank : 118)	θ value	θ > 10 (rank : 347)
Query Neighborhood Hits	263	Target Neighborhood Hits	1041	Shared Neighborhood Hits	103
SwissProt Accessions	Q9Y566, Q9NYW9	Gene names	SHANK1
Domain Architecture
Description	SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP).

EPHA3_HUMAN
NC score	0.069393 (rank : 119)	θ value	θ > 10 (rank : 297)
Query Neighborhood Hits	263	Target Neighborhood Hits	1005	Shared Neighborhood Hits	44
SwissProt Accessions	P29320, Q9H2V3, Q9H2V4	Gene names	EPHA3, ETK, ETK1, HEK
Domain Architecture
Description	Ephrin type-A receptor 3 precursor (EC 2.7.10.1) (Tyrosine-protein kinase receptor ETK1) (HEK) (HEK4).

DNMBP_HUMAN
NC score	0.068273 (rank : 120)	θ value	θ > 10 (rank : 293)
Query Neighborhood Hits	263	Target Neighborhood Hits	413	Shared Neighborhood Hits	56
SwissProt Accessions	Q6XZF7, Q8IVY3, Q9Y2L3	Gene names	DNMBP, KIAA1010
Domain Architecture	No domain graphic available
Description	Dynamin-binding protein (Scaffold protein Tuba).

AL2S4_MOUSE
NC score	0.067413 (rank : 121)	θ value	2.36792 (rank : 134)
Query Neighborhood Hits	263	Target Neighborhood Hits	193	Shared Neighborhood Hits	31
SwissProt Accessions	Q3V0J1, Q3TIS2	Gene names	Als2cr4
Domain Architecture	No domain graphic available
Description	Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein homolog.

ABI3_HUMAN
NC score	0.067259 (rank : 122)	θ value	θ > 10 (rank : 266)
Query Neighborhood Hits	263	Target Neighborhood Hits	227	Shared Neighborhood Hits	60
SwissProt Accessions	Q9P2A4, Q9H0P6	Gene names	ABI3, NESH
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

CASG_MOUSE
NC score	0.066992 (rank : 123)	θ value	6.88961 (rank : 216)
Query Neighborhood Hits	263	Target Neighborhood Hits	9	Shared Neighborhood Hits	3
SwissProt Accessions	Q02862	Gene names	Csng
Domain Architecture	No domain graphic available
Description	Gamma-casein precursor (PP22).

LCP2_HUMAN
NC score	0.066639 (rank : 124)	θ value	θ > 10 (rank : 318)
Query Neighborhood Hits	263	Target Neighborhood Hits	531	Shared Neighborhood Hits	57
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

IASPP_MOUSE
NC score	0.066405 (rank : 125)	θ value	θ > 10 (rank : 312)
Query Neighborhood Hits	263	Target Neighborhood Hits	1024	Shared Neighborhood Hits	100
SwissProt Accessions	Q5I1X5	Gene names	Ppp1r13l, Nkip1
Domain Architecture	No domain graphic available
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

NFH_MOUSE
NC score	0.066393 (rank : 126)	θ value	0.365318 (rank : 69)
Query Neighborhood Hits	263	Target Neighborhood Hits	2247	Shared Neighborhood Hits	127
SwissProt Accessions	P19246, Q5SVF6, Q61959	Gene names	Nefh, Nfh
Domain Architecture
Description	Neurofilament triplet H protein (200 kDa neurofilament protein) (Neurofilament heavy polypeptide) (NF-H).

MYO1F_HUMAN
NC score	0.065948 (rank : 127)	θ value	0.62314 (rank : 83)
Query Neighborhood Hits	263	Target Neighborhood Hits	275	Shared Neighborhood Hits	64
SwissProt Accessions	O00160, Q8WWN7	Gene names	MYO1F
Domain Architecture
Description	Myosin If (Myosin-IE).

STAM1_MOUSE
NC score	0.065943 (rank : 128)	θ value	θ > 10 (rank : 359)
Query Neighborhood Hits	263	Target Neighborhood Hits	273	Shared Neighborhood Hits	58
SwissProt Accessions	P70297	Gene names	Stam, Stam1
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 1 (STAM-1).

NCF4_MOUSE
NC score	0.065883 (rank : 129)	θ value	θ > 10 (rank : 329)
Query Neighborhood Hits	263	Target Neighborhood Hits	177	Shared Neighborhood Hits	48
SwissProt Accessions	P97369	Gene names	Ncf4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

ABI1_HUMAN
NC score	0.065030 (rank : 130)	θ value	θ > 10 (rank : 264)
Query Neighborhood Hits	263	Target Neighborhood Hits	257	Shared Neighborhood Hits	58
SwissProt Accessions	Q8IZP0, O15147, O76049, O95060, Q5W070, Q5W072, Q8TB63, Q96S81, Q9NXZ9, Q9NYB8	Gene names	ABI1, SSH3BP1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Nap1-binding protein) (Nap1BP) (Abl-binding protein 4) (AblBP4).

MBD6_HUMAN
NC score	0.065006 (rank : 131)	θ value	1.81305 (rank : 128)
Query Neighborhood Hits	263	Target Neighborhood Hits	349	Shared Neighborhood Hits	40
SwissProt Accessions	Q96DN6, Q8N3M0, Q8NA81, Q96Q00	Gene names	MBD6, KIAA1887
Domain Architecture	No domain graphic available
Description	Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6).

PCLO_MOUSE
NC score	0.064891 (rank : 132)	θ value	3.0926 (rank : 168)
Query Neighborhood Hits	263	Target Neighborhood Hits	2275	Shared Neighborhood Hits	127
SwissProt Accessions	Q9QYX7, Q8CF91, Q8CF92, Q9QYX6, Q9QZJ0	Gene names	Pclo, Acz
Domain Architecture
Description	Protein piccolo (Aczonin) (Multidomain presynaptic cytomatrix protein) (Brain-derived HLMN protein).

FMN2_HUMAN
NC score	0.064818 (rank : 133)	θ value	0.0113563 (rank : 24)
Query Neighborhood Hits	263	Target Neighborhood Hits	484	Shared Neighborhood Hits	47
SwissProt Accessions	Q9NZ56, Q59GF6, Q5VU37, Q9NZ55	Gene names	FMN2
Domain Architecture	No domain graphic available
Description	Formin-2.

BCAR1_HUMAN
NC score	0.064325 (rank : 134)	θ value	θ > 10 (rank : 277)
Query Neighborhood Hits	263	Target Neighborhood Hits	554	Shared Neighborhood Hits	84
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

STAC3_MOUSE
NC score	0.064321 (rank : 135)	θ value	θ > 10 (rank : 357)
Query Neighborhood Hits	263	Target Neighborhood Hits	232	Shared Neighborhood Hits	48
SwissProt Accessions	Q8BZ71	Gene names	Stac3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

M3K9_HUMAN
NC score	0.064173 (rank : 136)	θ value	0.21417 (rank : 62)
Query Neighborhood Hits	263	Target Neighborhood Hits	1123	Shared Neighborhood Hits	101
SwissProt Accessions	P80192, Q6EH31, Q9H2N5	Gene names	MAP3K9, MLK1, PRKE1
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 9 (EC 2.7.11.25) (Mixed lineage kinase 1).

CT032_HUMAN
NC score	0.064129 (rank : 137)	θ value	θ > 10 (rank : 288)
Query Neighborhood Hits	263	Target Neighborhood Hits	235	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NQ75, Q96K09, Q9BYL5	Gene names	HEFL, C20orf32
Domain Architecture
Description	HEF-like protein.

ASPP1_MOUSE
NC score	0.064090 (rank : 138)	θ value	θ > 10 (rank : 276)
Query Neighborhood Hits	263	Target Neighborhood Hits	1244	Shared Neighborhood Hits	111
SwissProt Accessions	Q62415	Gene names	Ppp1r13b, Aspp1
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

DDEF1_MOUSE
NC score	0.063971 (rank : 139)	θ value	θ > 10 (rank : 291)
Query Neighborhood Hits	263	Target Neighborhood Hits	592	Shared Neighborhood Hits	78
SwissProt Accessions	Q9QWY8, O08612, Q80TG8, Q80UV6, Q99LV8, Q9Z2B6	Gene names	Ddef1, Asap1, Kiaa1249, Shag1
Domain Architecture
Description	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase- activating protein (PIP2-dependent ARF1 GAP) (ADP-ribosylation factor- directed GTPase-activating protein 1) (ARF GTPase-activating protein 1) (Development and differentiation-enhancing factor 1) (Differentiation-enhancing factor 1) (DEF-1).

NCF4_HUMAN
NC score	0.063970 (rank : 140)	θ value	θ > 10 (rank : 328)
Query Neighborhood Hits	263	Target Neighborhood Hits	161	Shared Neighborhood Hits	45
SwissProt Accessions	Q15080, O60808, Q86U56, Q9BU98, Q9NP45	Gene names	NCF4
Domain Architecture
Description	Neutrophil cytosol factor 4 (NCF-4) (Neutrophil NADPH oxidase factor 4) (p40-phox) (p40phox).

STAC3_HUMAN
NC score	0.063934 (rank : 141)	θ value	θ > 10 (rank : 356)
Query Neighborhood Hits	263	Target Neighborhood Hits	228	Shared Neighborhood Hits	47
SwissProt Accessions	Q96MF2, Q96HU5	Gene names	STAC3
Domain Architecture	No domain graphic available
Description	SH3 and cysteine-rich domain-containing protein 3.

SRC8_MOUSE
NC score	0.063151 (rank : 142)	θ value	θ > 10 (rank : 351)
Query Neighborhood Hits	263	Target Neighborhood Hits	292	Shared Neighborhood Hits	54
SwissProt Accessions	Q60598	Gene names	Cttn, Ems1
Domain Architecture
Description	Src substrate cortactin.

DDEF2_MOUSE
NC score	0.062975 (rank : 143)	θ value	6.88961 (rank : 220)
Query Neighborhood Hits	263	Target Neighborhood Hits	625	Shared Neighborhood Hits	81
SwissProt Accessions	Q7SIG6, Q501K1, Q66JN2	Gene names	Ddef2
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

ABI1_MOUSE
NC score	0.062876 (rank : 144)	θ value	θ > 10 (rank : 265)
Query Neighborhood Hits	263	Target Neighborhood Hits	246	Shared Neighborhood Hits	52
SwissProt Accessions	Q8CBW3, Q60747, Q91ZM5, Q923I9, Q99KH4	Gene names	Abi1, Ssh3bp1
Domain Architecture	No domain graphic available
Description	Abl interactor 1 (Abelson interactor 1) (Abi-1) (Spectrin SH3 domain- binding protein 1) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (e3B1) (Ablphilin-1).

PPIP1_HUMAN
NC score	0.062811 (rank : 145)	θ value	θ > 10 (rank : 341)
Query Neighborhood Hits	263	Target Neighborhood Hits	389	Shared Neighborhood Hits	52
SwissProt Accessions	O43586, O43585, O95657	Gene names	PSTPIP1, CD2BP1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1) (CD2-binding protein 1) (H-PIP).

CEND1_MOUSE
NC score	0.062572 (rank : 146)	θ value	0.279714 (rank : 64)
Query Neighborhood Hits	263	Target Neighborhood Hits	260	Shared Neighborhood Hits	39
SwissProt Accessions	Q8BZ05, Q80TX2, Q8C3T2, Q8VEL6	Gene names	Centd1, Kiaa0580
Domain Architecture	No domain graphic available
Description	Centaurin-delta 1 (Cnt-d1).

PLCG1_MOUSE
NC score	0.062391 (rank : 147)	θ value	θ > 10 (rank : 339)
Query Neighborhood Hits	263	Target Neighborhood Hits	314	Shared Neighborhood Hits	54
SwissProt Accessions	Q62077, Q6P1G1	Gene names	Plcg1, Plcg-1
Domain Architecture	No domain graphic available
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

RTP3_MOUSE
NC score	0.062222 (rank : 148)	θ value	3.0926 (rank : 173)
Query Neighborhood Hits	263	Target Neighborhood Hits	374	Shared Neighborhood Hits	53
SwissProt Accessions	Q5QGU6, Q8VDC2	Gene names	Rtp3, Tmem7
Domain Architecture	No domain graphic available
Description	Receptor-transporting protein 3 (Transmembrane protein 7).

SRC8_HUMAN
NC score	0.062221 (rank : 149)	θ value	θ > 10 (rank : 350)
Query Neighborhood Hits	263	Target Neighborhood Hits	269	Shared Neighborhood Hits	50
SwissProt Accessions	Q14247	Gene names	CTTN, EMS1
Domain Architecture
Description	Src substrate cortactin (Amplaxin) (Oncogene EMS1).

STAM2_MOUSE
NC score	0.061984 (rank : 150)	θ value	θ > 10 (rank : 361)
Query Neighborhood Hits	263	Target Neighborhood Hits	285	Shared Neighborhood Hits	57
SwissProt Accessions	O88811, Q8C8Y4	Gene names	Stam2, Hbp
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2) (Hrs-binding protein).

CEND3_HUMAN
NC score	0.061965 (rank : 151)	θ value	4.03905 (rank : 181)
Query Neighborhood Hits	263	Target Neighborhood Hits	275	Shared Neighborhood Hits	55
SwissProt Accessions	Q8WWN8	Gene names	CENTD3, ARAP3
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3).

PRR13_HUMAN
NC score	0.061940 (rank : 152)	θ value	θ > 10 (rank : 343)
Query Neighborhood Hits	263	Target Neighborhood Hits	105	Shared Neighborhood Hits	11
SwissProt Accessions	Q9NZ81, Q6FIG7, Q6MZP8, Q6NXQ6, Q6PKF9	Gene names	PRR13
Domain Architecture	No domain graphic available
Description	Proline-rich protein 13.

RIN3_MOUSE
NC score	0.061866 (rank : 153)	θ value	0.47712 (rank : 76)
Query Neighborhood Hits	263	Target Neighborhood Hits	239	Shared Neighborhood Hits	32
SwissProt Accessions	P59729	Gene names	Rin3
Domain Architecture
Description	Ras and Rab interactor 3 (Ras interaction/interference protein 3).

PLCG1_HUMAN
NC score	0.061688 (rank : 154)	θ value	θ > 10 (rank : 338)
Query Neighborhood Hits	263	Target Neighborhood Hits	293	Shared Neighborhood Hits	52
SwissProt Accessions	P19174, Q2V575	Gene names	PLCG1, PLC1
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-1) (Phospholipase C-gamma-1) (PLC-II) (PLC-148).

PPIP1_MOUSE
NC score	0.061603 (rank : 155)	θ value	θ > 10 (rank : 342)
Query Neighborhood Hits	263	Target Neighborhood Hits	377	Shared Neighborhood Hits	53
SwissProt Accessions	P97814, Q4V9R4	Gene names	Pstpip1
Domain Architecture	No domain graphic available
Description	Proline-serine-threonine phosphatase-interacting protein 1 (PEST phosphatase-interacting protein 1).

IWS1_MOUSE
NC score	0.061602 (rank : 156)	θ value	0.813845 (rank : 88)
Query Neighborhood Hits	263	Target Neighborhood Hits	1258	Shared Neighborhood Hits	85
SwissProt Accessions	Q8C1D8, Q3TQ25, Q3UWB0, Q6NVD1, Q8BY73, Q9D9H4	Gene names	Iws1, Iws1l
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

TXND2_HUMAN
NC score	0.061567 (rank : 157)	θ value	θ > 10 (rank : 369)
Query Neighborhood Hits	263	Target Neighborhood Hits	793	Shared Neighborhood Hits	68
SwissProt Accessions	Q86VQ3, Q8N7U4, Q96RX3, Q9H0L8	Gene names	TXNDC2, SPTRX, SPTRX1
Domain Architecture	No domain graphic available
Description	Thioredoxin domain-containing protein 2 (Spermatid-specific thioredoxin-1) (Sptrx-1).

NPHP1_HUMAN
NC score	0.061262 (rank : 158)	θ value	θ > 10 (rank : 333)
Query Neighborhood Hits	263	Target Neighborhood Hits	288	Shared Neighborhood Hits	43
SwissProt Accessions	O15259, O14837	Gene names	NPHP1, NPH1
Domain Architecture
Description	Nephrocystin-1 (Juvenile nephronophthisis 1 protein).

RGS3_MOUSE
NC score	0.061119 (rank : 159)	θ value	0.62314 (rank : 86)
Query Neighborhood Hits	263	Target Neighborhood Hits	1621	Shared Neighborhood Hits	97
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

FYB_HUMAN
NC score	0.061067 (rank : 160)	θ value	1.81305 (rank : 125)
Query Neighborhood Hits	263	Target Neighborhood Hits	379	Shared Neighborhood Hits	55
SwissProt Accessions	O15117, O00359	Gene names	FYB, SLAP130
Domain Architecture
Description	FYN-binding protein (FYN-T-binding protein) (FYB-120/130) (p120/p130) (SLP-76-associated phosphoprotein) (SLAP-130).

IWS1_HUMAN
NC score	0.060969 (rank : 161)	θ value	3.0926 (rank : 161)
Query Neighborhood Hits	263	Target Neighborhood Hits	1241	Shared Neighborhood Hits	81
SwissProt Accessions	Q96ST2, Q6P157, Q8N3E8, Q96MI7, Q9NV97, Q9NWH8	Gene names	IWS1, IWS1L
Domain Architecture	No domain graphic available
Description	IWS1 homolog (IWS1-like protein).

ARHG4_HUMAN
NC score	0.060835 (rank : 162)	θ value	θ > 10 (rank : 271)
Query Neighborhood Hits	263	Target Neighborhood Hits	242	Shared Neighborhood Hits	49
SwissProt Accessions	Q9NR80, Q9HDC6, Q9UPP0	Gene names	ARHGEF4, KIAA1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

STAM2_HUMAN
NC score	0.060790 (rank : 163)	θ value	θ > 10 (rank : 360)
Query Neighborhood Hits	263	Target Neighborhood Hits	288	Shared Neighborhood Hits	56
SwissProt Accessions	O75886, Q7LDQ0, Q9UF58	Gene names	STAM2
Domain Architecture	No domain graphic available
Description	Signal transducing adapter molecule 2 (STAM-2).

SRRM1_MOUSE
NC score	0.060636 (rank : 164)	θ value	θ > 10 (rank : 355)
Query Neighborhood Hits	263	Target Neighborhood Hits	966	Shared Neighborhood Hits	72
SwissProt Accessions	Q52KI8, O70495, Q9CVG5	Gene names	Srrm1, Pop101
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Plenty-of-prolines 101).

DDEF2_HUMAN
NC score	0.060595 (rank : 165)	θ value	θ > 10 (rank : 292)
Query Neighborhood Hits	263	Target Neighborhood Hits	599	Shared Neighborhood Hits	77
SwissProt Accessions	O43150	Gene names	DDEF2, KIAA0400
Domain Architecture
Description	Development and differentiation-enhancing factor 2 (Pyk2 C-terminus- associated protein) (PAP) (Paxillin-associated protein with ARFGAP activity 3) (PAG3).

ABL1_MOUSE
NC score	0.060385 (rank : 166)	θ value	θ > 10 (rank : 269)
Query Neighborhood Hits	263	Target Neighborhood Hits	1178	Shared Neighborhood Hits	100
SwissProt Accessions	P00520, P97896, Q61252, Q61253, Q61254, Q61255, Q61256, Q61257, Q61258, Q61259, Q61260, Q61261, Q6PCM5, Q8C1X4	Gene names	Abl1, Abl
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

K1543_HUMAN
NC score	0.059729 (rank : 167)	θ value	0.813845 (rank : 90)
Query Neighborhood Hits	263	Target Neighborhood Hits	435	Shared Neighborhood Hits	50
SwissProt Accessions	Q9P1Y5, Q8NDF1	Gene names	KIAA1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

BCAR1_MOUSE
NC score	0.059709 (rank : 168)	θ value	θ > 10 (rank : 278)
Query Neighborhood Hits	263	Target Neighborhood Hits	438	Shared Neighborhood Hits	77
SwissProt Accessions	Q61140, Q60869	Gene names	Bcar1, Cas, Crkas
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

CEND3_MOUSE
NC score	0.059264 (rank : 169)	θ value	8.99809 (rank : 242)
Query Neighborhood Hits	263	Target Neighborhood Hits	228	Shared Neighborhood Hits	51
SwissProt Accessions	Q8R5G7, Q5DTN4, Q6NVF1, Q8R5G6	Gene names	Centd3, Arap3, Drag1, Kiaa4097
Domain Architecture	No domain graphic available
Description	Centaurin-delta 3 (Cnt-d3) (Arf-GAP, Rho-GAP, ankyrin repeat and pleckstrin homology domain-containing protein 3) (Dual specificity Rho- and Arf-GTPase-activating protein 1).

TPO_MOUSE
NC score	0.059231 (rank : 170)	θ value	θ > 10 (rank : 367)
Query Neighborhood Hits	263	Target Neighborhood Hits	258	Shared Neighborhood Hits	30
SwissProt Accessions	P40226	Gene names	Thpo
Domain Architecture
Description	Thrombopoietin precursor (Megakaryocyte colony-stimulating factor) (Myeloproliferative leukemia virus oncogene ligand) (C-mpl ligand) (ML) (Megakaryocyte growth and development factor) (MGDF).

ARHG4_MOUSE
NC score	0.059138 (rank : 171)	θ value	θ > 10 (rank : 272)
Query Neighborhood Hits	263	Target Neighborhood Hits	185	Shared Neighborhood Hits	45
SwissProt Accessions	Q7TNR9, Q80TJ6	Gene names	Arhgef4, Kiaa1112
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 4 (APC-stimulated guanine nucleotide exchange factor) (Asef).

MINT_MOUSE
NC score	0.058993 (rank : 172)	θ value	0.47712 (rank : 73)
Query Neighborhood Hits	263	Target Neighborhood Hits	1514	Shared Neighborhood Hits	91
SwissProt Accessions	Q62504, Q80TN9, Q99PS4, Q9QZW2	Gene names	Spen, Kiaa0929, Mint, Sharp
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

M3K11_HUMAN
NC score	0.058944 (rank : 173)	θ value	0.813845 (rank : 91)
Query Neighborhood Hits	263	Target Neighborhood Hits	1136	Shared Neighborhood Hits	106
SwissProt Accessions	Q16584, Q6P2G4	Gene names	MAP3K11, MLK3, SPRK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25) (Mixed lineage kinase 3) (Src-homology 3 domain-containing proline- rich kinase).

TCGAP_HUMAN
NC score	0.058487 (rank : 174)	θ value	θ > 10 (rank : 364)
Query Neighborhood Hits	263	Target Neighborhood Hits	872	Shared Neighborhood Hits	102
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

MAVS_HUMAN
NC score	0.058116 (rank : 175)	θ value	3.0926 (rank : 164)
Query Neighborhood Hits	263	Target Neighborhood Hits	271	Shared Neighborhood Hits	29
SwissProt Accessions	Q7Z434, Q3I0Y2, Q5T7I6, Q86VY7, Q9H1H3, Q9H4Y1, Q9H8D3, Q9ULE9	Gene names	MAVS, IPS1, KIAA1271, VISA
Domain Architecture	No domain graphic available
Description	Mitochondrial antiviral signaling protein (Interferon-beta promoter stimulator protein 1) (IPS-1) (Virus-induced signaling adapter) (CARD adapter inducing interferon-beta) (Cardif) (Putative NF-kappa-B- activating protein 031N).

ABI3_MOUSE
NC score	0.058016 (rank : 176)	θ value	θ > 10 (rank : 267)
Query Neighborhood Hits	263	Target Neighborhood Hits	227	Shared Neighborhood Hits	50
SwissProt Accessions	Q8BYZ1, Q6PE63, Q9D7S4	Gene names	Abi3, Nesh
Domain Architecture	No domain graphic available
Description	ABI gene family member 3 (New molecule including SH3) (Nesh).

LRC56_HUMAN
NC score	0.057775 (rank : 177)	θ value	0.0563607 (rank : 40)
Query Neighborhood Hits	263	Target Neighborhood Hits	165	Shared Neighborhood Hits	12
SwissProt Accessions	Q8IYG6, Q8N3Q4	Gene names	LRRC56
Domain Architecture	No domain graphic available
Description	Leucine-rich repeat-containing protein 56.

BSN_HUMAN
NC score	0.057708 (rank : 178)	θ value	θ > 10 (rank : 280)
Query Neighborhood Hits	263	Target Neighborhood Hits	1537	Shared Neighborhood Hits	90
SwissProt Accessions	Q9UPA5, O43161, Q7LGH3	Gene names	BSN, KIAA0434, ZNF231
Domain Architecture	No domain graphic available
Description	Protein bassoon (Zinc finger protein 231).

ARHG9_HUMAN
NC score	0.057602 (rank : 179)	θ value	θ > 10 (rank : 273)
Query Neighborhood Hits	263	Target Neighborhood Hits	235	Shared Neighborhood Hits	51
SwissProt Accessions	O43307, Q5JSL6	Gene names	ARHGEF9, KIAA0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin) (PEM-2 homolog).

SPTA3_MOUSE
NC score	0.057271 (rank : 180)	θ value	2.36792 (rank : 152)
Query Neighborhood Hits	263	Target Neighborhood Hits	74	Shared Neighborhood Hits	15
SwissProt Accessions	Q9D9T6, Q80ZS4, Q9D5L5, Q9DAF5	Gene names	Spata3, Tsarg1
Domain Architecture	No domain graphic available
Description	Spermatogenesis-associated protein 3 (Testis spermatocyte apoptosis- related protein 1) (Testis and spermatogenesis cell-related protein 1) (mTSARG1).

ARHG9_MOUSE
NC score	0.057118 (rank : 181)	θ value	θ > 10 (rank : 274)
Query Neighborhood Hits	263	Target Neighborhood Hits	234	Shared Neighborhood Hits	51
SwissProt Accessions	Q3UTH8, Q3TQ60, Q80U06, Q8CAF9	Gene names	Arhgef9, Kiaa0424
Domain Architecture	No domain graphic available
Description	Rho guanine nucleotide exchange factor 9 (Rac/Cdc42 guanine nucleotide exchange factor 9) (Collybistin).

PRRT3_HUMAN
NC score	0.057035 (rank : 182)	θ value	θ > 10 (rank : 344)
Query Neighborhood Hits	263	Target Neighborhood Hits	998	Shared Neighborhood Hits	71
SwissProt Accessions	Q5FWE3, Q49AD0, Q6UXY6, Q8NBC9	Gene names	PRRT3, UNQ5823/PRO19642
Domain Architecture	No domain graphic available
Description	Proline-rich transmembrane protein 3.

ANK2_HUMAN
NC score	0.056827 (rank : 183)	θ value	0.163984 (rank : 55)
Query Neighborhood Hits	263	Target Neighborhood Hits	1615	Shared Neighborhood Hits	102
SwissProt Accessions	Q01484, Q01485	Gene names	ANK2
Domain Architecture
Description	Ankyrin-2 (Brain ankyrin) (Ankyrin-B) (Ankyrin, nonerythroid).

NOXO1_MOUSE
NC score	0.056754 (rank : 184)	θ value	θ > 10 (rank : 332)
Query Neighborhood Hits	263	Target Neighborhood Hits	114	Shared Neighborhood Hits	36
SwissProt Accessions	Q8VCM2, Q3TZA4, Q8BH41, Q9D747	Gene names	Noxo1, Snx28
Domain Architecture	No domain graphic available
Description	NADPH oxidase organizer 1 (Nox organizer 1) (Sorting nexin-28).

K1802_MOUSE
NC score	0.056647 (rank : 185)	θ value	θ > 10 (rank : 316)
Query Neighborhood Hits	263	Target Neighborhood Hits	1596	Shared Neighborhood Hits	82
SwissProt Accessions	Q8K327, Q3UZ85, Q6ZPI1	Gene names	Kiaa1802, D8Ertd457e
Domain Architecture	No domain graphic available
Description	Zinc finger protein KIAA1802.

DBNL_MOUSE
NC score	0.055961 (rank : 186)	θ value	θ > 10 (rank : 290)
Query Neighborhood Hits	263	Target Neighborhood Hits	306	Shared Neighborhood Hits	58
SwissProt Accessions	Q62418, Q80WP1, Q8BH56	Gene names	Dbnl, Abp1, Sh3p7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Actin-binding protein 1).

YES_MOUSE
NC score	0.055852 (rank : 187)	θ value	θ > 10 (rank : 373)
Query Neighborhood Hits	263	Target Neighborhood Hits	1052	Shared Neighborhood Hits	84
SwissProt Accessions	Q04736	Gene names	Yes1, Yes
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

FYN_MOUSE
NC score	0.055717 (rank : 188)	θ value	θ > 10 (rank : 304)
Query Neighborhood Hits	263	Target Neighborhood Hits	1073	Shared Neighborhood Hits	83
SwissProt Accessions	P39688	Gene names	Fyn
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn).

NCOA6_HUMAN
NC score	0.055637 (rank : 189)	θ value	θ > 10 (rank : 330)
Query Neighborhood Hits	263	Target Neighborhood Hits	1202	Shared Neighborhood Hits	82
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

EFS_MOUSE
NC score	0.055574 (rank : 190)	θ value	θ > 10 (rank : 296)
Query Neighborhood Hits	263	Target Neighborhood Hits	389	Shared Neighborhood Hits	72
SwissProt Accessions	Q64355	Gene names	Efs, Sin
Domain Architecture
Description	Embryonal Fyn-associated substrate (SRC-interacting protein) (Signal- integrating protein).

YES_HUMAN
NC score	0.055561 (rank : 191)	θ value	θ > 10 (rank : 372)
Query Neighborhood Hits	263	Target Neighborhood Hits	1059	Shared Neighborhood Hits	84
SwissProt Accessions	P07947	Gene names	YES1, YES
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Yes (EC 2.7.10.2) (p61-Yes) (c- Yes).

PLCG2_HUMAN
NC score	0.055271 (rank : 192)	θ value	θ > 10 (rank : 340)
Query Neighborhood Hits	263	Target Neighborhood Hits	280	Shared Neighborhood Hits	50
SwissProt Accessions	P16885, Q969T5	Gene names	PLCG2
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma 2 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (PLC-gamma-2) (Phospholipase C-gamma-2) (PLC-IV).

FGR_HUMAN
NC score	0.055149 (rank : 193)	θ value	θ > 10 (rank : 300)
Query Neighborhood Hits	263	Target Neighborhood Hits	1067	Shared Neighborhood Hits	82
SwissProt Accessions	P09769, Q9UIQ3	Gene names	FGR, SRC2
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

DBNL_HUMAN
NC score	0.054556 (rank : 194)	θ value	θ > 10 (rank : 289)
Query Neighborhood Hits	263	Target Neighborhood Hits	244	Shared Neighborhood Hits	50
SwissProt Accessions	Q9UJU6, P84070, Q6IAI8, Q96F30, Q96K74, Q9HBN8, Q9NR72	Gene names	DBNL, CMAP, SH3P7
Domain Architecture	No domain graphic available
Description	Drebrin-like protein (SH3 domain-containing protein 7) (Drebrin F) (Cervical SH3P7) (HPK1-interacting protein of 55 kDa) (HIP-55) (Cervical mucin-associated protein).

FYN_HUMAN
NC score	0.054500 (rank : 195)	θ value	θ > 10 (rank : 303)
Query Neighborhood Hits	263	Target Neighborhood Hits	1078	Shared Neighborhood Hits	82
SwissProt Accessions	P06241	Gene names	FYN
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2) (p59-Fyn) (Protooncogene Syn) (SLK).

FGR_MOUSE
NC score	0.054244 (rank : 196)	θ value	θ > 10 (rank : 301)
Query Neighborhood Hits	263	Target Neighborhood Hits	1069	Shared Neighborhood Hits	82
SwissProt Accessions	P14234, Q61404	Gene names	Fgr
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase FGR (EC 2.7.10.2) (P55-FGR) (C- FGR).

SRC_HUMAN
NC score	0.054184 (rank : 197)	θ value	θ > 10 (rank : 352)
Query Neighborhood Hits	263	Target Neighborhood Hits	1058	Shared Neighborhood Hits	81
SwissProt Accessions	P12931, Q86VB9, Q9H5A8	Gene names	SRC, SRC1
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c- Src) (pp60c-src).

ASPP1_HUMAN
NC score	0.053895 (rank : 198)	θ value	θ > 10 (rank : 275)
Query Neighborhood Hits	263	Target Neighborhood Hits	956	Shared Neighborhood Hits	87
SwissProt Accessions	Q96KQ4, O94870	Gene names	PPP1R13B, ASPP1, KIAA0771
Domain Architecture
Description	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B).

PACN2_MOUSE
NC score	0.053793 (rank : 199)	θ value	θ > 10 (rank : 337)
Query Neighborhood Hits	263	Target Neighborhood Hits	382	Shared Neighborhood Hits	57
SwissProt Accessions	Q9WVE8	Gene names	Pacsin2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

PACN2_HUMAN
NC score	0.053429 (rank : 200)	θ value	θ > 10 (rank : 336)
Query Neighborhood Hits	263	Target Neighborhood Hits	339	Shared Neighborhood Hits	53
SwissProt Accessions	Q9UNF0, O95921, Q96HV9, Q9H0D3, Q9NPN1, Q9Y4V2	Gene names	PACSIN2
Domain Architecture
Description	Protein kinase C and casein kinase substrate in neurons protein 2.

ABL1_HUMAN
NC score	0.053330 (rank : 201)	θ value	θ > 10 (rank : 268)
Query Neighborhood Hits	263	Target Neighborhood Hits	1220	Shared Neighborhood Hits	99
SwissProt Accessions	P00519, Q13869, Q13870, Q16133, Q45F09	Gene names	ABL1, ABL, JTK7
Domain Architecture
Description	Proto-oncogene tyrosine-protein kinase ABL1 (EC 2.7.10.2) (p150) (c- ABL) (Abelson murine leukemia viral oncogene homolog 1).

SRRM1_HUMAN
NC score	0.053199 (rank : 202)	θ value	θ > 10 (rank : 354)
Query Neighborhood Hits	263	Target Neighborhood Hits	690	Shared Neighborhood Hits	60
SwissProt Accessions	Q8IYB3, O60585, Q5VVN4	Gene names	SRRM1, SRM160
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 1 (Ser/Arg-related nuclear matrix protein) (SR-related nuclear matrix protein of 160 kDa) (SRm160).

BTK_HUMAN
NC score	0.053096 (rank : 203)	θ value	θ > 10 (rank : 281)
Query Neighborhood Hits	263	Target Neighborhood Hits	1026	Shared Neighborhood Hits	83
SwissProt Accessions	Q06187	Gene names	BTK, AGMX1, ATK, BPK
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK).

LCP2_MOUSE
NC score	0.052797 (rank : 204)	θ value	1.06291 (rank : 105)
Query Neighborhood Hits	263	Target Neighborhood Hits	177	Shared Neighborhood Hits	30
SwissProt Accessions	Q60787	Gene names	Lcp2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

BTK_MOUSE
NC score	0.052657 (rank : 205)	θ value	θ > 10 (rank : 282)
Query Neighborhood Hits	263	Target Neighborhood Hits	1017	Shared Neighborhood Hits	83
SwissProt Accessions	P35991, Q61365	Gene names	Btk, Bpk
Domain Architecture
Description	Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB).

SON_MOUSE
NC score	0.052426 (rank : 206)	θ value	θ > 10 (rank : 348)
Query Neighborhood Hits	263	Target Neighborhood Hits	957	Shared Neighborhood Hits	70
SwissProt Accessions	Q9QX47, Q9CQ12, Q9CQK6, Q9QXP5	Gene names	Son
Domain Architecture
Description	SON protein.

HCK_MOUSE
NC score	0.052371 (rank : 207)	θ value	θ > 10 (rank : 308)
Query Neighborhood Hits	263	Target Neighborhood Hits	1029	Shared Neighborhood Hits	81
SwissProt Accessions	P08103	Gene names	Hck
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p56-HCK/p59-HCK) (Hemopoietic cell kinase) (B-cell/myeloid kinase) (BMK).

HCK_HUMAN
NC score	0.052288 (rank : 208)	θ value	θ > 10 (rank : 307)
Query Neighborhood Hits	263	Target Neighborhood Hits	1035	Shared Neighborhood Hits	80
SwissProt Accessions	P08631, Q5T7K1, Q5T7K2, Q96CC0, Q9H5Y5, Q9NUA4, Q9UMJ5	Gene names	HCK
Domain Architecture
Description	Tyrosine-protein kinase HCK (EC 2.7.10.2) (p59-HCK/p60-HCK) (Hemopoietic cell kinase).

LAD1_MOUSE
NC score	0.052082 (rank : 209)	θ value	θ > 10 (rank : 317)
Query Neighborhood Hits	263	Target Neighborhood Hits	391	Shared Neighborhood Hits	42
SwissProt Accessions	P57016	Gene names	Lad1
Domain Architecture	No domain graphic available
Description	Ladinin 1 (Lad-1) (Linear IgA disease autoantigen).

PINX1_HUMAN
NC score	0.052026 (rank : 210)	θ value	0.163984 (rank : 57)
Query Neighborhood Hits	263	Target Neighborhood Hits	65	Shared Neighborhood Hits	5
SwissProt Accessions	Q96BK5, Q7Z7J8, Q96QD7, Q9HBU7, Q9NWW2	Gene names	PINX1, LPTS
Domain Architecture
Description	Pin2-interacting protein X1 (TRF1-interacting protein 1) (Liver- related putative tumor suppressor) (67-11-3 protein).

M3KL4_HUMAN
NC score	0.051969 (rank : 211)	θ value	θ > 10 (rank : 321)
Query Neighborhood Hits	263	Target Neighborhood Hits	1087	Shared Neighborhood Hits	86
SwissProt Accessions	Q5TCX8, Q5TCX7, Q5TCX9, Q8WWN1, Q8WWN2, Q96JM1	Gene names	MLK4, KIAA1804
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase (EC 2.7.11.25) (Mixed lineage kinase 4).

IASPP_HUMAN
NC score	0.051894 (rank : 212)	θ value	θ > 10 (rank : 311)
Query Neighborhood Hits	263	Target Neighborhood Hits	688	Shared Neighborhood Hits	81
SwissProt Accessions	Q8WUF5, Q2PNZ9, Q5DU71, Q5I1X4, Q6P1R7, Q6PKF8, Q9Y290	Gene names	PPP1R13L, IASPP, NKIP1, PPP1R13BL, RAI
Domain Architecture
Description	RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (PPP1R13B-like protein) (NFkB-interacting protein 1).

LYN_HUMAN
NC score	0.051835 (rank : 213)	θ value	θ > 10 (rank : 319)
Query Neighborhood Hits	263	Target Neighborhood Hits	1022	Shared Neighborhood Hits	80
SwissProt Accessions	P07948	Gene names	LYN
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

PHC2_HUMAN
NC score	0.051807 (rank : 214)	θ value	3.0926 (rank : 169)
Query Neighborhood Hits	263	Target Neighborhood Hits	388	Shared Neighborhood Hits	40
SwissProt Accessions	Q8IXK0, Q5T0C1, Q6NUJ6, Q6ZQR1, Q8N306, Q8TAG8, Q96BL4, Q9Y4Y7	Gene names	PHC2, EDR2, PH2
Domain Architecture	No domain graphic available
Description	Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2).

SRC_MOUSE
NC score	0.051801 (rank : 215)	θ value	θ > 10 (rank : 353)
Query Neighborhood Hits	263	Target Neighborhood Hits	1033	Shared Neighborhood Hits	77
SwissProt Accessions	P05480	Gene names	Src
Domain Architecture
Description	Neuronal proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (p60-Src) (c-Src) (pp60c-src).

RAPH1_HUMAN
NC score	0.051793 (rank : 216)	θ value	5.27518 (rank : 206)
Query Neighborhood Hits	263	Target Neighborhood Hits	593	Shared Neighborhood Hits	68
SwissProt Accessions	Q70E73, Q96Q37, Q9C0I2	Gene names	RAPH1, ALS2CR9, KIAA1681, LPD, PREL2, RMO1
Domain Architecture	No domain graphic available
Description	Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) (Lamellipodin) (Proline-rich EVH1 ligand 2) (PREL-2) (Protein RMO1) (Amyotrophic lateral sclerosis 2 chromosomal region candidate 9 gene protein).

CSK_HUMAN
NC score	0.051715 (rank : 217)	θ value	θ > 10 (rank : 286)
Query Neighborhood Hits	263	Target Neighborhood Hits	1009	Shared Neighborhood Hits	75
SwissProt Accessions	P41240, Q6FGZ6	Gene names	CSK
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase CYL).

MUC7_HUMAN
NC score	0.051598 (rank : 218)	θ value	θ > 10 (rank : 325)
Query Neighborhood Hits	263	Target Neighborhood Hits	538	Shared Neighborhood Hits	51
SwissProt Accessions	Q8TAX7	Gene names	MUC7, MG2
Domain Architecture	No domain graphic available
Description	Mucin-7 precursor (MUC-7) (Salivary mucin-7) (Apo-MG2).

LYN_MOUSE
NC score	0.051544 (rank : 219)	θ value	θ > 10 (rank : 320)
Query Neighborhood Hits	263	Target Neighborhood Hits	1023	Shared Neighborhood Hits	79
SwissProt Accessions	P25911, Q62127	Gene names	Lyn
Domain Architecture
Description	Tyrosine-protein kinase Lyn (EC 2.7.10.2).

EFS_HUMAN
NC score	0.051375 (rank : 220)	θ value	θ > 10 (rank : 295)
Query Neighborhood Hits	263	Target Neighborhood Hits	348	Shared Neighborhood Hits	68
SwissProt Accessions	O43281, O43282	Gene names	EFS
Domain Architecture
Description	Embryonal Fyn-associated substrate (HEFS).

CSK_MOUSE
NC score	0.051304 (rank : 221)	θ value	θ > 10 (rank : 287)
Query Neighborhood Hits	263	Target Neighborhood Hits	1009	Shared Neighborhood Hits	75
SwissProt Accessions	P41241, Q03143	Gene names	Csk
Domain Architecture
Description	Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-SRC kinase) (Protein- tyrosine kinase MPK-2) (p50CSK).

TEX14_HUMAN
NC score	0.051280 (rank : 222)	θ value	θ > 10 (rank : 365)
Query Neighborhood Hits	263	Target Neighborhood Hits	1103	Shared Neighborhood Hits	70
SwissProt Accessions	Q8IWB6, Q7RTP3, Q8ND97, Q9BXT9	Gene names	TEX14
Domain Architecture	No domain graphic available
Description	Testis-expressed protein 14 (Testis-expressed sequence 14).

MAP4_HUMAN
NC score	0.051237 (rank : 223)	θ value	θ > 10 (rank : 322)
Query Neighborhood Hits	263	Target Neighborhood Hits	428	Shared Neighborhood Hits	47
SwissProt Accessions	P27816, Q13082, Q96A76	Gene names	MAP4
Domain Architecture
Description	Microtubule-associated protein 4 (MAP 4).

MYO1F_MOUSE
NC score	0.051219 (rank : 224)	θ value	6.88961 (rank : 225)
Query Neighborhood Hits	263	Target Neighborhood Hits	262	Shared Neighborhood Hits	55
SwissProt Accessions	P70248	Gene names	Myo1f
Domain Architecture
Description	Myosin If.

CK024_HUMAN
NC score	0.051187 (rank : 225)	θ value	θ > 10 (rank : 284)
Query Neighborhood Hits	263	Target Neighborhood Hits	408	Shared Neighborhood Hits	46
SwissProt Accessions	Q96F05, Q9H2K4	Gene names	C11orf24
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C11orf24 precursor (Protein DM4E3).

TM108_MOUSE
NC score	0.050943 (rank : 226)	θ value	θ > 10 (rank : 366)
Query Neighborhood Hits	263	Target Neighborhood Hits	336	Shared Neighborhood Hits	36
SwissProt Accessions	Q8BHE4, Q80WR9	Gene names	Tmem108
Domain Architecture	No domain graphic available
Description	Transmembrane protein 108 precursor.

TXK_MOUSE
NC score	0.050852 (rank : 227)	θ value	θ > 10 (rank : 368)
Query Neighborhood Hits	263	Target Neighborhood Hits	980	Shared Neighborhood Hits	76
SwissProt Accessions	P42682	Gene names	Txk, Rlk
Domain Architecture
Description	Tyrosine-protein kinase TXK (EC 2.7.10.2) (PTK-RL-18) (Resting lymphocyte kinase).

FRK_HUMAN
NC score	0.050828 (rank : 228)	θ value	θ > 10 (rank : 302)
Query Neighborhood Hits	263	Target Neighborhood Hits	1058	Shared Neighborhood Hits	82
SwissProt Accessions	P42685, Q13128	Gene names	FRK
Domain Architecture
Description	Tyrosine-protein kinase FRK (EC 2.7.10.2) (Nuclear tyrosine protein kinase RAK).

ABL2_HUMAN
NC score	0.050782 (rank : 229)	θ value	θ > 10 (rank : 270)
Query Neighborhood Hits	263	Target Neighborhood Hits	1045	Shared Neighborhood Hits	78
SwissProt Accessions	P42684, Q5T0X6, Q6NZY6	Gene names	ABL2, ABLL, ARG
Domain Architecture
Description	Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Tyrosine kinase ARG).

NEBL_HUMAN
NC score	0.050485 (rank : 230)	θ value	θ > 10 (rank : 331)
Query Neighborhood Hits	263	Target Neighborhood Hits	457	Shared Neighborhood Hits	59
SwissProt Accessions	O76041, Q9UIC4	Gene names	NEBL
Domain Architecture
Description	Nebulette (Actin-binding Z-disk protein).

ILK_MOUSE
NC score	0.050440 (rank : 231)	θ value	θ > 10 (rank : 315)
Query Neighborhood Hits	263	Target Neighborhood Hits	858	Shared Neighborhood Hits	48
SwissProt Accessions	O55222	Gene names	Ilk
Domain Architecture
Description	Integrin-linked protein kinase (EC 2.7.11.1).

SPR1B_MOUSE
NC score	0.050423 (rank : 232)	θ value	θ > 10 (rank : 349)
Query Neighborhood Hits	263	Target Neighborhood Hits	395	Shared Neighborhood Hits	46
SwissProt Accessions	Q62267	Gene names	Sprr1b
Domain Architecture
Description	Cornifin B (Small proline-rich protein 1B) (SPR1B) (SPR1 B).

CN155_HUMAN
NC score	0.050350 (rank : 233)	θ value	θ > 10 (rank : 285)
Query Neighborhood Hits	263	Target Neighborhood Hits	385	Shared Neighborhood Hits	38
SwissProt Accessions	Q5H9T9, Q5H9U7, Q86YI2, Q9H0J3	Gene names	C14orf155
Domain Architecture	No domain graphic available
Description	Protein C14orf155.

TARA_HUMAN
NC score	0.050282 (rank : 234)	θ value	θ > 10 (rank : 362)
Query Neighborhood Hits	263	Target Neighborhood Hits	1626	Shared Neighborhood Hits	89
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

ILK2_HUMAN
NC score	0.050268 (rank : 235)	θ value	θ > 10 (rank : 314)
Query Neighborhood Hits	263	Target Neighborhood Hits	848	Shared Neighborhood Hits	47
SwissProt Accessions	P57043	Gene names	ILK2
Domain Architecture
Description	Integrin-linked protein kinase 2 (EC 2.7.11.1) (ILK-2).

CASL_MOUSE
NC score	0.050255 (rank : 236)	θ value	θ > 10 (rank : 283)
Query Neighborhood Hits	263	Target Neighborhood Hits	225	Shared Neighborhood Hits	57
SwissProt Accessions	O35177, Q8BJL8, Q8BK90, Q8BL52, Q8BM94, Q8BMI9, Q99KE7	Gene names	Nedd9, Casl
Domain Architecture
Description	Enhancer of filamentation 1 (MEF1) (CRK-associated substrate-related protein) (CAS-L) (p105) (Protein NEDD9) (Neural precursor cell expressed developmentally down-regulated protein 9).

MLL2_HUMAN
NC score	0.050162 (rank : 237)	θ value	θ > 10 (rank : 324)
Query Neighborhood Hits	263	Target Neighborhood Hits	1788	Shared Neighborhood Hits	100
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

ILK1_HUMAN
NC score	0.050120 (rank : 238)	θ value	θ > 10 (rank : 313)
Query Neighborhood Hits	263	Target Neighborhood Hits	857	Shared Neighborhood Hits	47
SwissProt Accessions	Q13418	Gene names	ILK, ILK1
Domain Architecture
Description	Integrin-linked protein kinase 1 (EC 2.7.11.1) (ILK-1) (59 kDa serine/threonine-protein kinase) (p59ILK).

BLK_MOUSE
NC score	0.050025 (rank : 239)	θ value	θ > 10 (rank : 279)
Query Neighborhood Hits	263	Target Neighborhood Hits	992	Shared Neighborhood Hits	75
SwissProt Accessions	P16277	Gene names	Blk
Domain Architecture
Description	Tyrosine-protein kinase BLK (EC 2.7.10.2) (B lymphocyte kinase) (p55- BLK).

PSL1_HUMAN
NC score	0.049133 (rank : 240)	θ value	6.88961 (rank : 231)
Query Neighborhood Hits	263	Target Neighborhood Hits	650	Shared Neighborhood Hits	61
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

MLL4_HUMAN
NC score	0.048518 (rank : 241)	θ value	6.88961 (rank : 224)
Query Neighborhood Hits	263	Target Neighborhood Hits	722	Shared Neighborhood Hits	60
SwissProt Accessions	Q9UMN6, O15022, O95836, Q96GP2, Q96IP3, Q9UK25, Q9Y668, Q9Y669	Gene names	MLL4, HRX2, KIAA0304, MLL2, TRX2
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 4 (Trithorax homolog 2).

PDZD2_HUMAN
NC score	0.047886 (rank : 242)	θ value	2.36792 (rank : 148)
Query Neighborhood Hits	263	Target Neighborhood Hits	772	Shared Neighborhood Hits	66
SwissProt Accessions	O15018, Q9BXD4	Gene names	PDZD2, AIPC, KIAA0300, PDZK3
Domain Architecture	No domain graphic available
Description	PDZ domain-containing protein 2 (PDZ domain-containing protein 3) (Activated in prostate cancer protein).

IF2P_HUMAN
NC score	0.047800 (rank : 243)	θ value	1.38821 (rank : 115)
Query Neighborhood Hits	263	Target Neighborhood Hits	889	Shared Neighborhood Hits	39
SwissProt Accessions	O60841, O95805, Q9UF81, Q9UMN7	Gene names	EIF5B, IF2, KIAA0741
Domain Architecture
Description	Eukaryotic translation initiation factor 5B (eIF-5B) (Translation initiation factor IF-2).

NOL1_HUMAN
NC score	0.047749 (rank : 244)	θ value	0.813845 (rank : 92)
Query Neighborhood Hits	263	Target Neighborhood Hits	74	Shared Neighborhood Hits	11
SwissProt Accessions	P46087	Gene names	NOL1
Domain Architecture
Description	Proliferating-cell nucleolar antigen p120 (Proliferation-associated nucleolar protein p120).

AATK_HUMAN
NC score	0.047060 (rank : 245)	θ value	2.36792 (rank : 133)
Query Neighborhood Hits	263	Target Neighborhood Hits	1243	Shared Neighborhood Hits	83
SwissProt Accessions	Q6ZMQ8, O75136, Q6ZN31, Q86X28	Gene names	AATK, KIAA0641
Domain Architecture	No domain graphic available
Description	Apoptosis-associated tyrosine-protein kinase (EC 2.7.10.2) (AATYK) (Brain apoptosis-associated tyrosine kinase) (CDK5-binding protein) (p35-binding protein) (p35BP).

CECR2_HUMAN
NC score	0.046752 (rank : 246)	θ value	4.03905 (rank : 180)
Query Neighborhood Hits	263	Target Neighborhood Hits	543	Shared Neighborhood Hits	47
SwissProt Accessions	Q9BXF3, Q658Z4, Q96P58, Q9C0C3	Gene names	CECR2, KIAA1740
Domain Architecture
Description	Cat eye syndrome critical region protein 2.

BRD4_HUMAN
NC score	0.046738 (rank : 247)	θ value	0.279714 (rank : 63)
Query Neighborhood Hits	263	Target Neighborhood Hits	851	Shared Neighborhood Hits	57
SwissProt Accessions	O60885, O60433, Q96PD3	Gene names	BRD4, HUNK1
Domain Architecture
Description	Bromodomain-containing protein 4 (HUNK1 protein).

JADE2_MOUSE
NC score	0.046349 (rank : 248)	θ value	1.06291 (rank : 104)
Query Neighborhood Hits	263	Target Neighborhood Hits	560	Shared Neighborhood Hits	52
SwissProt Accessions	Q6ZQF7, Q3UHD5, Q6IE83	Gene names	Phf15, Jade2, Kiaa0239
Domain Architecture	No domain graphic available
Description	Protein Jade-2 (PHD finger protein 15).

HRX_HUMAN
NC score	0.043988 (rank : 249)	θ value	6.88961 (rank : 221)
Query Neighborhood Hits	263	Target Neighborhood Hits	825	Shared Neighborhood Hits	63
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

BRD4_MOUSE
NC score	0.043542 (rank : 250)	θ value	2.36792 (rank : 136)
Query Neighborhood Hits	263	Target Neighborhood Hits	845	Shared Neighborhood Hits	60
SwissProt Accessions	Q9ESU6, Q8VHF7, Q8VHF8	Gene names	Brd4, Mcap
Domain Architecture	No domain graphic available
Description	Bromodomain-containing protein 4 (Mitotic chromosome-associated protein) (MCAP).

DGKK_HUMAN
NC score	0.042936 (rank : 251)	θ value	1.06291 (rank : 99)
Query Neighborhood Hits	263	Target Neighborhood Hits	378	Shared Neighborhood Hits	42
SwissProt Accessions	Q5KSL6	Gene names	DGKK
Domain Architecture	No domain graphic available
Description	Diacylglycerol kinase kappa (EC 2.7.1.107) (Diglyceride kinase kappa) (DGK-kappa) (DAG kinase kappa) (142 kDa diacylglycerol kinase).

ZCPW1_HUMAN
NC score	0.042385 (rank : 252)	θ value	0.47712 (rank : 77)
Query Neighborhood Hits	263	Target Neighborhood Hits	116	Shared Neighborhood Hits	11
SwissProt Accessions	Q9H0M4, Q8NA98, Q9BUD0, Q9NWF7	Gene names	ZCWPW1
Domain Architecture	No domain graphic available
Description	Zinc finger CW-type PWWP domain protein 1.

MKL1_MOUSE
NC score	0.042040 (rank : 253)	θ value	1.38821 (rank : 117)
Query Neighborhood Hits	263	Target Neighborhood Hits	667	Shared Neighborhood Hits	59
SwissProt Accessions	Q8K4J6	Gene names	Mkl1, Bsac
Domain Architecture
Description	MKL/myocardin-like protein 1 (Myocardin-related transcription factor A) (MRTF-A) (Megakaryoblastic leukemia 1 protein homolog) (Basic SAP coiled-coil transcription activator).

RAI1_HUMAN
NC score	0.041052 (rank : 254)	θ value	2.36792 (rank : 150)
Query Neighborhood Hits	263	Target Neighborhood Hits	360	Shared Neighborhood Hits	40
SwissProt Accessions	Q7Z5J4, Q8N3B4, Q8ND08, Q8WU64, Q96JK5, Q9H1C1, Q9H1C2, Q9UF69	Gene names	RAI1, KIAA1820
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 1.

APC_HUMAN
NC score	0.040975 (rank : 255)	θ value	3.0926 (rank : 156)
Query Neighborhood Hits	263	Target Neighborhood Hits	603	Shared Neighborhood Hits	49
SwissProt Accessions	P25054, Q15162, Q15163, Q93042	Gene names	APC, DP2.5
Domain Architecture
Description	Adenomatous polyposis coli protein (Protein APC).

CAC2D_MOUSE
NC score	0.040463 (rank : 256)	θ value	1.06291 (rank : 96)
Query Neighborhood Hits	263	Target Neighborhood Hits	42	Shared Neighborhood Hits	5
SwissProt Accessions	O08532, O08533, O08534, O08535, O08536	Gene names	Cacna2d1, Cacna2
Domain Architecture
Description	Dihydropyridine-sensitive L-type calcium channel subunits alpha- 2/delta precursor [Contains: L-type calcium channel subunit alpha-2; L-type calcium channel subunit delta].

BORG5_HUMAN
NC score	0.039892 (rank : 257)	θ value	2.36792 (rank : 135)
Query Neighborhood Hits	263	Target Neighborhood Hits	135	Shared Neighborhood Hits	18
SwissProt Accessions	Q00587, Q96GN1	Gene names	CDC42EP1, BORG5, CEP1, MSE55
Domain Architecture
Description	Cdc42 effector protein 1 (Binder of Rho GTPases 5) (Serum protein MSE55).

JHD2A_MOUSE
NC score	0.038655 (rank : 258)	θ value	2.36792 (rank : 144)
Query Neighborhood Hits	263	Target Neighborhood Hits	123	Shared Neighborhood Hits	21
SwissProt Accessions	Q6PCM1, Q2MJQ6, Q3TKW8, Q3UML3, Q6ZQ57, Q8K2J6, Q8K2K4, Q8R350	Gene names	Jmjd1a, Jhdm2a, Kiaa0742
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2A (EC 1.14.11.-) (Jumonji domain-containing protein 1A).

NHS_HUMAN
NC score	0.038425 (rank : 259)	θ value	5.27518 (rank : 203)
Query Neighborhood Hits	263	Target Neighborhood Hits	198	Shared Neighborhood Hits	29
SwissProt Accessions	Q6T4R5, Q5J7Q0, Q5J7Q1, Q68DR5	Gene names	NHS
Domain Architecture	No domain graphic available
Description	Nance-Horan syndrome protein (Congenital cataracts and dental anomalies protein).

GON4L_MOUSE
NC score	0.038342 (rank : 260)	θ value	1.38821 (rank : 114)
Query Neighborhood Hits	263	Target Neighborhood Hits	455	Shared Neighborhood Hits	43
SwissProt Accessions	Q9DB00, Q80TB4, Q91YI9	Gene names	Gon4l, Gon4, KIAA1606
Domain Architecture	No domain graphic available
Description	GON-4-like protein (GON-4 homolog).

MYST3_MOUSE
NC score	0.037986 (rank : 261)	θ value	0.0431538 (rank : 35)
Query Neighborhood Hits	263	Target Neighborhood Hits	688	Shared Neighborhood Hits	47
SwissProt Accessions	Q8BZ21, Q8BW52, Q8BYH1, Q8C1F3	Gene names	Myst3, Moz
Domain Architecture	No domain graphic available
Description	Histone acetyltransferase MYST3 (EC 2.3.1.48) (EC 2.3.1.-) (MYST protein 3) (MOZ, YBF2/SAS3, SAS2 and TIP60 protein 3) (Monocytic leukemia zinc finger protein) (Monocytic leukemia zinc finger homolog).

RERE_HUMAN
NC score	0.037152 (rank : 262)	θ value	6.88961 (rank : 232)
Query Neighborhood Hits	263	Target Neighborhood Hits	779	Shared Neighborhood Hits	48
SwissProt Accessions	Q9P2R6, O43393, O75046, O75359, Q5VXL9, Q6P6B9, Q9Y2W4	Gene names	RERE, ARG, ARP, ATN1L, KIAA0458
Domain Architecture	No domain graphic available
Description	Arginine-glutamic acid dipeptide repeats protein (Atrophin-1-like protein) (Atrophin-1-related protein).

FGFR1_MOUSE
NC score	0.037081 (rank : 263)	θ value	8.99809 (rank : 246)
Query Neighborhood Hits	263	Target Neighborhood Hits	1068	Shared Neighborhood Hits	42
SwissProt Accessions	P16092, Q01736, Q61562, Q80T10	Gene names	Fgfr1, Flg
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (MFR) (CD331 antigen).

FGFR1_HUMAN
NC score	0.037060 (rank : 264)	θ value	8.99809 (rank : 245)
Query Neighborhood Hits	263	Target Neighborhood Hits	1069	Shared Neighborhood Hits	42
SwissProt Accessions	P11362, P17049, Q02063, Q02065, Q14306, Q14307, Q8N685	Gene names	FGFR1, FGFBR, FLG, FLT2
Domain Architecture
Description	Basic fibroblast growth factor receptor 1 precursor (EC 2.7.10.1) (FGFR-1) (bFGF-R) (Fms-like tyrosine kinase 2) (c-fgr) (CD331 antigen).

MAST4_HUMAN
NC score	0.036676 (rank : 265)	θ value	1.81305 (rank : 127)
Query Neighborhood Hits	263	Target Neighborhood Hits	1804	Shared Neighborhood Hits	112
SwissProt Accessions	O15021, Q6ZN07, Q96LY3	Gene names	MAST4, KIAA0303
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 4 (EC 2.7.11.1).

ATX7_HUMAN
NC score	0.036606 (rank : 266)	θ value	8.99809 (rank : 239)
Query Neighborhood Hits	263	Target Neighborhood Hits	351	Shared Neighborhood Hits	41
SwissProt Accessions	O15265, O75328, O75329, Q9Y6P8	Gene names	ATXN7, SCA7
Domain Architecture	No domain graphic available
Description	Ataxin-7 (Spinocerebellar ataxia type 7 protein).

BAIP2_HUMAN
NC score	0.036545 (rank : 267)	θ value	1.81305 (rank : 120)
Query Neighborhood Hits	263	Target Neighborhood Hits	192	Shared Neighborhood Hits	26
SwissProt Accessions	Q9UQB8, O43858, Q53HB1, Q86WC1, Q8N5C0, Q96CR7, Q9UBR3, Q9UQ43	Gene names	BAIAP2
Domain Architecture	No domain graphic available
Description	Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI1- associated protein 2) (BAI-associated protein 2) (Protein BAP2) (Insulin receptor substrate p53) (IRSp53) (Insulin receptor substrate protein of 53 kDa) (Insulin receptor substrate p53/p58) (IRSp53/58) (IRS-58) (Fas ligand-associated factor 3) (FLAF3).

SYNJ1_HUMAN
NC score	0.036382 (rank : 268)	θ value	4.03905 (rank : 190)
Query Neighborhood Hits	263	Target Neighborhood Hits	498	Shared Neighborhood Hits	54
SwissProt Accessions	O43426, O43425, O94984	Gene names	SYNJ1, KIAA0910
Domain Architecture
Description	Synaptojanin-1 (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate 5- phosphatase 1).

SC24C_HUMAN
NC score	0.035912 (rank : 269)	θ value	3.0926 (rank : 174)
Query Neighborhood Hits	263	Target Neighborhood Hits	662	Shared Neighborhood Hits	48
SwissProt Accessions	P53992, Q8WV25	Gene names	SEC24C, KIAA0079
Domain Architecture
Description	Protein transport protein Sec24C (SEC24-related protein C).

JHD2A_HUMAN
NC score	0.034985 (rank : 270)	θ value	0.813845 (rank : 89)
Query Neighborhood Hits	263	Target Neighborhood Hits	118	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Y4C1, Q53S72, Q68D47, Q68UT9, Q6N050, Q8IY08	Gene names	JMJD1A, JHDM2A, JMJD1, KIAA0742
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 2A (EC 1.14.11.-) (Jumonji domain-containing protein 1A).

DDFL1_HUMAN
NC score	0.034734 (rank : 271)	θ value	1.38821 (rank : 111)
Query Neighborhood Hits	263	Target Neighborhood Hits	353	Shared Neighborhood Hits	22
SwissProt Accessions	Q8TDY4, Q6P9F4, Q86UY1, Q9NXK2	Gene names	DDEFL1, UPLC1
Domain Architecture	No domain graphic available
Description	Development and differentiation-enhancing factor-like 1 (Protein up- regulated in liver cancer 1).

REXO1_HUMAN
NC score	0.034046 (rank : 272)	θ value	3.0926 (rank : 172)
Query Neighborhood Hits	263	Target Neighborhood Hits	242	Shared Neighborhood Hits	31
SwissProt Accessions	Q8N1G1, Q9ULT2	Gene names	REXO1, ELOABP1, KIAA1138, TCEB3BP1
Domain Architecture	No domain graphic available
Description	RNA exonuclease 1 homolog (EC 3.1.-.-) (Elongin A-binding protein 1) (EloA-BP1) (Transcription elongation factor B polypeptide 3-binding protein 1).

THAP7_MOUSE
NC score	0.033505 (rank : 273)	θ value	1.38821 (rank : 119)
Query Neighborhood Hits	263	Target Neighborhood Hits	64	Shared Neighborhood Hits	6
SwissProt Accessions	Q8VCZ3	Gene names	Thap7
Domain Architecture
Description	THAP domain-containing protein 7.

CDSN_MOUSE
NC score	0.033171 (rank : 274)	θ value	1.38821 (rank : 110)
Query Neighborhood Hits	263	Target Neighborhood Hits	131	Shared Neighborhood Hits	8
SwissProt Accessions	Q7TPC1	Gene names	Cdsn
Domain Architecture	No domain graphic available
Description	Corneodesmosin precursor.

EHMT1_HUMAN
NC score	0.033147 (rank : 275)	θ value	5.27518 (rank : 196)
Query Neighborhood Hits	263	Target Neighborhood Hits	417	Shared Neighborhood Hits	22
SwissProt Accessions	Q9H9B1, Q8TCN7, Q96F53, Q96JF1, Q96KH4	Gene names	EHMT1, EUHMTASE1, KIAA1876
Domain Architecture
Description	Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 (EC 2.1.1.43) (Histone H3-K9 methyltransferase 5) (H3-K9-HMTase 5) (Euchromatic histone-lysine N-methyltransferase 1) (Eu-HMTase1) (G9a- like protein 1) (GLP1).

IF4G1_MOUSE
NC score	0.032846 (rank : 276)	θ value	5.27518 (rank : 198)
Query Neighborhood Hits	263	Target Neighborhood Hits	534	Shared Neighborhood Hits	46
SwissProt Accessions	Q6NZJ6, Q6NZN8, Q8BW99	Gene names	Eif4g1
Domain Architecture	No domain graphic available
Description	Eukaryotic translation initiation factor 4 gamma 1 (eIF-4-gamma 1) (eIF-4G1) (eIF-4G 1).

WNK4_HUMAN
NC score	0.032259 (rank : 277)	θ value	0.365318 (rank : 70)
Query Neighborhood Hits	263	Target Neighborhood Hits	1043	Shared Neighborhood Hits	70
SwissProt Accessions	Q96J92, Q8N8X3, Q8N8Z2, Q96DT8, Q9BYS5	Gene names	WNK4, PRKWNK4
Domain Architecture
Description	Serine/threonine-protein kinase WNK4 (EC 2.7.11.1) (Protein kinase with no lysine 4) (Protein kinase, lysine-deficient 4).

NAF1_HUMAN
NC score	0.031958 (rank : 278)	θ value	0.0961366 (rank : 49)
Query Neighborhood Hits	263	Target Neighborhood Hits	937	Shared Neighborhood Hits	39
SwissProt Accessions	Q15025, O76008, Q96EL9, Q99833, Q9H1J3	Gene names	TNIP1, KIAA0113, NAF1
Domain Architecture
Description	Nef-associated factor 1 (Naf1) (TNFAIP3-interacting protein 1) (HIV-1 Nef-interacting protein) (Virion-associated nuclear shuttling protein) (VAN) (hVAN) (Nip40-1).

CAC2D_HUMAN
NC score	0.031725 (rank : 279)	θ value	3.0926 (rank : 157)
Query Neighborhood Hits	263	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	P54289	Gene names	CACNA2D1, CACNL2A, CCHL2A
Domain Architecture
Description	Dihydropyridine-sensitive L-type calcium channel subunits alpha- 2/delta precursor [Contains: L-type calcium channel subunit alpha-2; L-type calcium channel subunit delta].

T22D4_HUMAN
NC score	0.031496 (rank : 280)	θ value	6.88961 (rank : 235)
Query Neighborhood Hits	263	Target Neighborhood Hits	403	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y3Q8	Gene names	TSC22D4, TILZ2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1).

NEO1_MOUSE
NC score	0.031221 (rank : 281)	θ value	2.36792 (rank : 145)
Query Neighborhood Hits	263	Target Neighborhood Hits	523	Shared Neighborhood Hits	36
SwissProt Accessions	P97798	Gene names	Neo1, Ngn
Domain Architecture
Description	Neogenin precursor.

SGIP1_HUMAN
NC score	0.031060 (rank : 282)	θ value	8.99809 (rank : 253)
Query Neighborhood Hits	263	Target Neighborhood Hits	198	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BQI5, Q4LE32, Q5VYE2, Q5VYE3, Q5VYE4, Q68D76, Q6MZY6, Q8IWC2	Gene names	SGIP1
Domain Architecture	No domain graphic available
Description	SH3-containing GRB2-like protein 3-interacting protein 1 (Endophilin- 3-interacting protein).

MILK1_HUMAN
NC score	0.030976 (rank : 283)	θ value	5.27518 (rank : 202)
Query Neighborhood Hits	263	Target Neighborhood Hits	427	Shared Neighborhood Hits	42
SwissProt Accessions	Q8N3F8, Q5TI16, Q7RTP5, Q8N3N8, Q9BVL9, Q9BY92, Q9UH43, Q9UH44, Q9UH45	Gene names	MIRAB13, KIAA1668
Domain Architecture
Description	Molecule interacting with Rab13 (MIRab13) (MICAL-like protein 1).

WASF4_HUMAN
NC score	0.030777 (rank : 284)	θ value	8.99809 (rank : 260)
Query Neighborhood Hits	263	Target Neighborhood Hits	282	Shared Neighborhood Hits	33
SwissProt Accessions	Q8IV90	Gene names	WASF4, SCAR2
Domain Architecture	No domain graphic available
Description	Wiskott-Aldrich syndrome protein family member 4 (WASP-family protein member 4).

K0179_HUMAN
NC score	0.030480 (rank : 285)	θ value	5.27518 (rank : 199)
Query Neighborhood Hits	263	Target Neighborhood Hits	81	Shared Neighborhood Hits	9
SwissProt Accessions	Q14684, Q8TBZ4	Gene names	KIAA0179
Domain Architecture
Description	Protein KIAA0179.

PWWP2_HUMAN
NC score	0.030352 (rank : 286)	θ value	5.27518 (rank : 205)
Query Neighborhood Hits	263	Target Neighborhood Hits	80	Shared Neighborhood Hits	14
SwissProt Accessions	Q6NUJ5, Q5SZI0, Q6ZQX5, Q96F43	Gene names	PWWP2
Domain Architecture	No domain graphic available
Description	PWWP domain-containing protein 2.

ANTR1_MOUSE
NC score	0.030102 (rank : 287)	θ value	4.03905 (rank : 178)
Query Neighborhood Hits	263	Target Neighborhood Hits	143	Shared Neighborhood Hits	26
SwissProt Accessions	Q9CZ52	Gene names	Antxr1, Atr, Tem8
Domain Architecture
Description	Anthrax toxin receptor 1 precursor (Tumor endothelial marker 8).

TITIN_HUMAN
NC score	0.029928 (rank : 288)	θ value	2.36792 (rank : 154)
Query Neighborhood Hits	263	Target Neighborhood Hits	2923	Shared Neighborhood Hits	114
SwissProt Accessions	Q8WZ42, Q10465, Q10466, Q15598, Q2XUS3, Q32Q60, Q4U1Z6, Q6NSG0, Q6PDB1, Q6PJP0, Q7KYM2, Q7KYN4, Q7KYN5, Q7LDM3, Q7Z2X3, Q8TCG8, Q8WZ51, Q8WZ52, Q8WZ53, Q8WZB3, Q92761, Q92762, Q9UD97, Q9UP84, Q9Y6L9	Gene names	TTN
Domain Architecture	No domain graphic available
Description	Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS- 40.14).

BAZ2A_HUMAN
NC score	0.029127 (rank : 289)	θ value	8.99809 (rank : 240)
Query Neighborhood Hits	263	Target Neighborhood Hits	780	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UIF9, O00536, O15030, Q96H26	Gene names	BAZ2A, KIAA0314, TIP5
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3).

CSKP_HUMAN
NC score	0.029110 (rank : 290)	θ value	4.03905 (rank : 182)
Query Neighborhood Hits	263	Target Neighborhood Hits	1022	Shared Neighborhood Hits	79
SwissProt Accessions	O14936, O43215, Q9NYB3	Gene names	CASK, LIN2
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (hCASK) (Calcium/calmodulin-dependent serine protein kinase) (Lin-2 homolog).

PRC1_MOUSE
NC score	0.029090 (rank : 291)	θ value	3.0926 (rank : 170)
Query Neighborhood Hits	263	Target Neighborhood Hits	382	Shared Neighborhood Hits	19
SwissProt Accessions	Q99K43, Q8CE25	Gene names	Prc1
Domain Architecture	No domain graphic available
Description	Protein regulator of cytokinesis 1.

CSKP_MOUSE
NC score	0.028832 (rank : 292)	θ value	4.03905 (rank : 183)
Query Neighborhood Hits	263	Target Neighborhood Hits	1027	Shared Neighborhood Hits	81
SwissProt Accessions	O70589, O70588	Gene names	Cask
Domain Architecture
Description	Peripheral plasma membrane protein CASK (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase).

EVC_HUMAN
NC score	0.028495 (rank : 293)	θ value	5.27518 (rank : 197)
Query Neighborhood Hits	263	Target Neighborhood Hits	129	Shared Neighborhood Hits	9
SwissProt Accessions	P57679	Gene names	EVC
Domain Architecture	No domain graphic available
Description	Ellis-van Creveld syndrome protein (DWF-1).

ETV3_HUMAN
NC score	0.028485 (rank : 294)	θ value	1.38821 (rank : 113)
Query Neighborhood Hits	263	Target Neighborhood Hits	312	Shared Neighborhood Hits	36
SwissProt Accessions	P41162, Q8TAC8, Q9BX30	Gene names	ETV3, METS, PE1
Domain Architecture	No domain graphic available
Description	ETS translocation variant 3 (ETS-domain transcriptional repressor PE1) (PE-1) (Mitogenic Ets transcriptional suppressor).

RAI14_HUMAN
NC score	0.028419 (rank : 295)	θ value	3.0926 (rank : 171)
Query Neighborhood Hits	263	Target Neighborhood Hits	1367	Shared Neighborhood Hits	47
SwissProt Accessions	Q9P0K7, Q6V1W9, Q7Z5I4, Q7Z733, Q9P2L2, Q9Y3T5	Gene names	RAI14, KIAA1334, NORPEG
Domain Architecture	No domain graphic available
Description	Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Retinoic acid-induced protein 14) (Novel retinal pigment epithelial cell protein).

EF2K_MOUSE
NC score	0.028212 (rank : 296)	θ value	1.06291 (rank : 100)
Query Neighborhood Hits	263	Target Neighborhood Hits	33	Shared Neighborhood Hits	5
SwissProt Accessions	O08796	Gene names	Eef2k
Domain Architecture
Description	Elongation factor 2 kinase (EC 2.7.11.20) (eEF-2 kinase) (eEF-2K) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase).

SYK_HUMAN
NC score	0.027978 (rank : 297)	θ value	1.81305 (rank : 130)
Query Neighborhood Hits	263	Target Neighborhood Hits	19	Shared Neighborhood Hits	3
SwissProt Accessions	Q15046, O14946, Q96J25	Gene names	KARS, KIAA0070
Domain Architecture
Description	Lysyl-tRNA synthetase (EC 6.1.1.6) (Lysine--tRNA ligase) (LysRS).

JPH1_MOUSE
NC score	0.027928 (rank : 298)	θ value	1.38821 (rank : 116)
Query Neighborhood Hits	263	Target Neighborhood Hits	120	Shared Neighborhood Hits	18
SwissProt Accessions	Q9ET80, Q9EQZ3	Gene names	Jph1, Jp1
Domain Architecture
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

NMT2_HUMAN
NC score	0.027799 (rank : 299)	θ value	0.47712 (rank : 74)
Query Neighborhood Hits	263	Target Neighborhood Hits	10	Shared Neighborhood Hits	2
SwissProt Accessions	O60551, Q53Y38, Q5VUC8, Q9BRB4	Gene names	NMT2
Domain Architecture
Description	Glycylpeptide N-tetradecanoyltransferase 2 (EC 2.3.1.97) (Peptide N- myristoyltransferase 2) (Myristoyl-CoA:protein N-myristoyltransferase 2) (NMT 2) (Type II N-myristoyltransferase).

CD68_MOUSE
NC score	0.027590 (rank : 300)	θ value	2.36792 (rank : 137)
Query Neighborhood Hits	263	Target Neighborhood Hits	41	Shared Neighborhood Hits	3
SwissProt Accessions	P31996	Gene names	Cd68
Domain Architecture
Description	Macrosialin precursor (CD68 antigen).

SSA27_MOUSE
NC score	0.026836 (rank : 301)	θ value	4.03905 (rank : 189)
Query Neighborhood Hits	263	Target Neighborhood Hits	14	Shared Neighborhood Hits	7
SwissProt Accessions	P56873	Gene names	Sssca1, C184l
Domain Architecture
Description	Sjoegren syndrome/scleroderma autoantigen 1 homolog (Autoantigen p27 homolog) (Protein C184L).

SVIL_MOUSE
NC score	0.026314 (rank : 302)	θ value	5.27518 (rank : 210)
Query Neighborhood Hits	263	Target Neighborhood Hits	439	Shared Neighborhood Hits	36
SwissProt Accessions	Q8K4L3	Gene names	Svil
Domain Architecture	No domain graphic available
Description	Supervillin (Archvillin) (p205/p250).

BRPF1_HUMAN
NC score	0.026123 (rank : 303)	θ value	1.06291 (rank : 95)
Query Neighborhood Hits	263	Target Neighborhood Hits	259	Shared Neighborhood Hits	22
SwissProt Accessions	P55201, Q9UHI0	Gene names	BRPF1, BR140
Domain Architecture
Description	Peregrin (Bromodomain and PHD finger-containing protein 1) (BR140 protein).

MAST3_HUMAN
NC score	0.025963 (rank : 304)	θ value	0.00298849 (rank : 16)
Query Neighborhood Hits	263	Target Neighborhood Hits	1128	Shared Neighborhood Hits	64
SwissProt Accessions	O60307, Q7LDZ8, Q9UPI0	Gene names	MAST3, KIAA0561
Domain Architecture	No domain graphic available
Description	Microtubule-associated serine/threonine-protein kinase 3 (EC 2.7.11.1).

ZWINT_HUMAN
NC score	0.025582 (rank : 305)	θ value	4.03905 (rank : 193)
Query Neighborhood Hits	263	Target Neighborhood Hits	333	Shared Neighborhood Hits	22
SwissProt Accessions	O95229, Q9BWD0	Gene names	ZWINT
Domain Architecture	No domain graphic available
Description	ZW10 interactor (ZW10-interacting protein 1) (Zwint-1).

PHLB1_MOUSE
NC score	0.025343 (rank : 306)	θ value	2.36792 (rank : 149)
Query Neighborhood Hits	263	Target Neighborhood Hits	678	Shared Neighborhood Hits	41
SwissProt Accessions	Q6PDH0, Q80TV2	Gene names	Phldb1, Kiaa0638, Ll5a
Domain Architecture	No domain graphic available
Description	Pleckstrin homology-like domain family B member 1 (Protein LL5-alpha).

CLSPN_MOUSE
NC score	0.025233 (rank : 307)	θ value	3.0926 (rank : 158)
Query Neighborhood Hits	263	Target Neighborhood Hits	292	Shared Neighborhood Hits	21
SwissProt Accessions	Q80YR7, Q69GM2	Gene names	Clspn
Domain Architecture	No domain graphic available
Description	Claspin.

OBSCN_HUMAN
NC score	0.025097 (rank : 308)	θ value	8.99809 (rank : 251)
Query Neighborhood Hits	263	Target Neighborhood Hits	1931	Shared Neighborhood Hits	91
SwissProt Accessions	Q5VST9, Q2A664, Q5T7G8, Q5T7G9, Q5VSU2, Q86YC7, Q8NHN0, Q8NHN1, Q8NHN2, Q8NHN4, Q8NHN5, Q8NHN6, Q8NHN7, Q8NHN8, Q8NHN9, Q96AA2, Q9HCD3, Q9HCL6	Gene names	OBSCN, KIAA1556, KIAA1639
Domain Architecture	No domain graphic available
Description	Obscurin (Obscurin-myosin light chain kinase) (Obscurin-MLCK) (Obscurin-RhoGEF).

THAP7_HUMAN
NC score	0.024968 (rank : 309)	θ value	6.88961 (rank : 236)
Query Neighborhood Hits	263	Target Neighborhood Hits	59	Shared Neighborhood Hits	9
SwissProt Accessions	Q9BT49	Gene names	THAP7
Domain Architecture
Description	THAP domain-containing protein 7.

MARK3_MOUSE
NC score	0.024397 (rank : 310)	θ value	5.27518 (rank : 201)
Query Neighborhood Hits	263	Target Neighborhood Hits	919	Shared Neighborhood Hits	50
SwissProt Accessions	Q03141, Q3TM40, Q3V1U3, Q8C6G9, Q8R375, Q9JKE4	Gene names	Mark3, Emk2, Mpk10
Domain Architecture	No domain graphic available
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (MPK-10) (ELKL motif kinase 2).

RN169_HUMAN
NC score	0.024238 (rank : 311)	θ value	4.03905 (rank : 188)
Query Neighborhood Hits	263	Target Neighborhood Hits	203	Shared Neighborhood Hits	11
SwissProt Accessions	Q8NCN4, Q6N015	Gene names	RNF169, KIAA1991
Domain Architecture	No domain graphic available
Description	RING finger protein 169.

GFAP_HUMAN
NC score	0.024219 (rank : 312)	θ value	0.0431538 (rank : 34)
Query Neighborhood Hits	263	Target Neighborhood Hits	723	Shared Neighborhood Hits	20
SwissProt Accessions	P14136, Q53H98, Q5D055, Q6ZQS3, Q7Z5J6, Q7Z5J7, Q96KS4, Q96P18, Q9UFD0	Gene names	GFAP
Domain Architecture
Description	Glial fibrillary acidic protein, astrocyte (GFAP).

RN168_MOUSE
NC score	0.023995 (rank : 313)	θ value	1.06291 (rank : 107)
Query Neighborhood Hits	263	Target Neighborhood Hits	440	Shared Neighborhood Hits	13
SwissProt Accessions	Q80XJ2	Gene names	Rnf168
Domain Architecture	No domain graphic available
Description	RING finger protein 168.

MARK3_HUMAN
NC score	0.023866 (rank : 314)	θ value	3.0926 (rank : 163)
Query Neighborhood Hits	263	Target Neighborhood Hits	893	Shared Neighborhood Hits	52
SwissProt Accessions	P27448, O60219, Q8TB41, Q8WX83, Q96RG1, Q9UMY9, Q9UN34	Gene names	MARK3, CTAK1
Domain Architecture
Description	MAP/microtubule affinity-regulating kinase 3 (EC 2.7.11.1) (Cdc25C- associated protein kinase 1) (cTAK1) (C-TAK1) (Serine/threonine protein kinase p78) (Ser/Thr protein kinase PAR-1) (Protein kinase STK10).

FHOD1_HUMAN
NC score	0.023690 (rank : 315)	θ value	8.99809 (rank : 247)
Query Neighborhood Hits	263	Target Neighborhood Hits	184	Shared Neighborhood Hits	19
SwissProt Accessions	Q9Y613, Q59F76, Q6Y1F2, Q76MS8, Q8N521	Gene names	FHOD1, FHOS
Domain Architecture
Description	FH1/FH2 domain-containing protein (Formin homolog overexpressed in spleen) (FHOS) (Formin homology 2 domain-containing protein 1).

BAZ2B_HUMAN
NC score	0.023269 (rank : 316)	θ value	5.27518 (rank : 195)
Query Neighborhood Hits	263	Target Neighborhood Hits	803	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UIF8, Q96EA1, Q96SQ8, Q9P252, Q9Y4N8	Gene names	BAZ2B, KIAA1476
Domain Architecture
Description	Bromodomain adjacent to zinc finger domain 2B (hWALp4).

PCX1_HUMAN
NC score	0.023147 (rank : 317)	θ value	2.36792 (rank : 147)
Query Neighborhood Hits	263	Target Neighborhood Hits	102	Shared Neighborhood Hits	8
SwissProt Accessions	Q96RV3, O94897, Q96AI7, Q9Y2J9	Gene names	PCNX, KIAA0805, KIAA0995, PCNXL1
Domain Architecture
Description	Pecanex-like protein 1 (Pecanex homolog).

CDT1_MOUSE
NC score	0.022972 (rank : 318)	θ value	8.99809 (rank : 241)
Query Neighborhood Hits	263	Target Neighborhood Hits	72	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R4E9, Q8BUQ1, Q8BX29, Q8R3V0, Q8R4E8	Gene names	Cdt1, Ris2
Domain Architecture	No domain graphic available
Description	DNA replication factor Cdt1 (Double parked homolog) (DUP) (Retroviral insertion site 2 protein).

SSRP1_HUMAN
NC score	0.022949 (rank : 319)	θ value	2.36792 (rank : 153)
Query Neighborhood Hits	263	Target Neighborhood Hits	187	Shared Neighborhood Hits	8
SwissProt Accessions	Q08945, Q5BJG8	Gene names	SSRP1, FACT80
Domain Architecture
Description	FACT complex subunit SSRP1 (Facilitates chromatin transcription complex subunit SSRP1) (FACT 80 kDa subunit) (FACTp80) (Chromatin- specific transcription elongation factor 80 kDa subunit) (Structure- specific recognition protein 1) (hSSRP1) (Recombination signal sequence recognition protein 1) (T160).

PRGC2_MOUSE
NC score	0.022805 (rank : 320)	θ value	5.27518 (rank : 204)
Query Neighborhood Hits	263	Target Neighborhood Hits	225	Shared Neighborhood Hits	20
SwissProt Accessions	Q8VHJ7, Q8C1C0	Gene names	Ppargc1b, Errl1, Pgc1, Pgc1b, Ppargc1
Domain Architecture	No domain graphic available
Description	Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPAR gamma coactivator-1beta protein) (PGC-1beta) (ERR ligand 1) (PPARGC-1-beta) (PGC-1-beta).

ROBO3_MOUSE
NC score	0.022783 (rank : 321)	θ value	1.06291 (rank : 108)
Query Neighborhood Hits	263	Target Neighborhood Hits	524	Shared Neighborhood Hits	43
SwissProt Accessions	Q9Z2I4	Gene names	Robo3, Rbig1
Domain Architecture
Description	Roundabout homolog 3 precursor (Retinoblastoma-inhibiting gene 1) (Rig-1).

NCOA7_HUMAN
NC score	0.022614 (rank : 322)	θ value	1.81305 (rank : 129)
Query Neighborhood Hits	263	Target Neighborhood Hits	160	Shared Neighborhood Hits	8
SwissProt Accessions	Q8NI08, Q3LID6, Q4G0V1, Q5TF95, Q6IPQ4, Q6NE83, Q86T89, Q8N1W4	Gene names	NCOA7, ERAP140, ESNA1
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 7 (140 kDa estrogen receptor-associated protein) (Estrogen nuclear receptor coactivator 1).

APBA1_HUMAN
NC score	0.022551 (rank : 323)	θ value	4.03905 (rank : 179)
Query Neighborhood Hits	263	Target Neighborhood Hits	325	Shared Neighborhood Hits	20
SwissProt Accessions	Q02410, O14914, O60570, Q5VYR8	Gene names	APBA1, MINT1, X11
Domain Architecture
Description	Amyloid beta A4 precursor protein-binding family A member 1 (Neuron- specific X11 protein) (Neuronal Munc18-1-interacting protein 1) (Mint- 1) (Adapter protein X11alpha).

NOP5_HUMAN
NC score	0.022534 (rank : 324)	θ value	3.0926 (rank : 166)
Query Neighborhood Hits	263	Target Neighborhood Hits	84	Shared Neighborhood Hits	7
SwissProt Accessions	Q9Y2X3, Q6PK08, Q9P036, Q9UFN3	Gene names	NOP5
Domain Architecture
Description	Nucleolar protein NOP5 (Nucleolar protein 5) (NOP58).

MYPN_HUMAN
NC score	0.021158 (rank : 325)	θ value	0.62314 (rank : 84)
Query Neighborhood Hits	263	Target Neighborhood Hits	418	Shared Neighborhood Hits	24
SwissProt Accessions	Q86TC9, Q5VV35, Q5VV36, Q86T37, Q8N3L4, Q96K90, Q96KF5	Gene names	MYPN, MYOP
Domain Architecture	No domain graphic available
Description	Myopalladin (145 kDa sarcomeric protein).

GFAP_MOUSE
NC score	0.020889 (rank : 326)	θ value	0.62314 (rank : 81)
Query Neighborhood Hits	263	Target Neighborhood Hits	725	Shared Neighborhood Hits	22
SwissProt Accessions	P03995, Q7TQ30, Q925K3	Gene names	Gfap
Domain Architecture
Description	Glial fibrillary acidic protein, astrocyte (GFAP).

GT2D1_MOUSE
NC score	0.020808 (rank : 327)	θ value	1.81305 (rank : 126)
Query Neighborhood Hits	263	Target Neighborhood Hits	36	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JI57, Q8VHD5, Q8VI58, Q9EQE7, Q9ESZ6, Q9ESZ7	Gene names	Gtf2ird1, Ben
Domain Architecture
Description	General transcription factor II-I repeat domain-containing protein 1 (GTF2I repeat domain-containing protein 1) (Binding factor for early enhancer).

SYK_MOUSE
NC score	0.020446 (rank : 328)	θ value	8.99809 (rank : 257)
Query Neighborhood Hits	263	Target Neighborhood Hits	20	Shared Neighborhood Hits	3
SwissProt Accessions	Q99MN1	Gene names	Kars
Domain Architecture
Description	Lysyl-tRNA synthetase (EC 6.1.1.6) (Lysine--tRNA ligase) (LysRS).

CLCN2_MOUSE
NC score	0.019868 (rank : 329)	θ value	2.36792 (rank : 138)
Query Neighborhood Hits	263	Target Neighborhood Hits	34	Shared Neighborhood Hits	4
SwissProt Accessions	Q9R0A1, Q9WUJ9	Gene names	Clcn2, Clc2
Domain Architecture
Description	Chloride channel protein 2 (ClC-2).

PLCB1_HUMAN
NC score	0.019464 (rank : 330)	θ value	6.88961 (rank : 229)
Query Neighborhood Hits	263	Target Neighborhood Hits	614	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NQ66, O60325, Q5TFF7, Q5TGC9, Q8IV93, Q9BQW2, Q9H4H2, Q9H8H5, Q9NQ65, Q9NQH9, Q9NTH4, Q9UJP6, Q9UM26	Gene names	PLCB1, KIAA0581
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

BORG1_HUMAN
NC score	0.019240 (rank : 331)	θ value	6.88961 (rank : 215)
Query Neighborhood Hits	263	Target Neighborhood Hits	67	Shared Neighborhood Hits	11
SwissProt Accessions	O14613, Q9UNS0	Gene names	CDC42EP2, BORG1, CEP2
Domain Architecture	No domain graphic available
Description	Cdc42 effector protein 2 (Binder of Rho GTPases 1).

DSPP_MOUSE
NC score	0.018738 (rank : 332)	θ value	8.99809 (rank : 244)
Query Neighborhood Hits	263	Target Neighborhood Hits	491	Shared Neighborhood Hits	25
SwissProt Accessions	P97399, O70567	Gene names	Dspp
Domain Architecture	No domain graphic available
Description	Dentin sialophosphoprotein precursor (Dentin matrix protein 3) (DMP-3) [Contains: Dentin phosphoprotein (Dentin phosphophoryn) (DPP); Dentin sialoprotein (DSP)].

IQGA2_HUMAN
NC score	0.018659 (rank : 333)	θ value	2.36792 (rank : 141)
Query Neighborhood Hits	263	Target Neighborhood Hits	200	Shared Neighborhood Hits	6
SwissProt Accessions	Q13576	Gene names	IQGAP2
Domain Architecture
Description	Ras GTPase-activating-like protein IQGAP2.

DHX37_HUMAN
NC score	0.018250 (rank : 334)	θ value	1.38821 (rank : 112)
Query Neighborhood Hits	263	Target Neighborhood Hits	133	Shared Neighborhood Hits	14
SwissProt Accessions	Q8IY37, Q9BUI7, Q9P211	Gene names	DHX37, DDX37, KIAA1517
Domain Architecture
Description	Probable ATP-dependent RNA helicase DHX37 (EC 3.6.1.-) (DEAH box protein 37).

CDN1B_HUMAN
NC score	0.018078 (rank : 335)	θ value	6.88961 (rank : 217)
Query Neighborhood Hits	263	Target Neighborhood Hits	27	Shared Neighborhood Hits	7
SwissProt Accessions	P46527, Q16307, Q9BUS6	Gene names	CDKN1B, KIP1
Domain Architecture
Description	Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1).

IRX5_HUMAN
NC score	0.017928 (rank : 336)	θ value	2.36792 (rank : 142)
Query Neighborhood Hits	263	Target Neighborhood Hits	362	Shared Neighborhood Hits	19
SwissProt Accessions	P78411, P78416, Q7Z2E1	Gene names	IRX5, IRX2A, IRXB2
Domain Architecture
Description	Iroquois-class homeodomain protein IRX-5 (Iroquois homeobox protein 5) (Homeodomain protein IRXB2) (IRX-2A).

OTOF_MOUSE
NC score	0.017705 (rank : 337)	θ value	3.0926 (rank : 167)
Query Neighborhood Hits	263	Target Neighborhood Hits	196	Shared Neighborhood Hits	10
SwissProt Accessions	Q9ESF1, Q9ESF2	Gene names	Otof, Fer1l2
Domain Architecture
Description	Otoferlin (Fer-1-like protein 2).

DAF1_MOUSE
NC score	0.017508 (rank : 338)	θ value	3.0926 (rank : 159)
Query Neighborhood Hits	263	Target Neighborhood Hits	204	Shared Neighborhood Hits	19
SwissProt Accessions	Q61475, P97732, Q61397	Gene names	Cd55a, Daf1
Domain Architecture
Description	Complement decay-accelerating factor, GPI-anchored precursor (DAF-GPI) (CD55 antigen).

CIR_MOUSE
NC score	0.017503 (rank : 339)	θ value	6.88961 (rank : 218)
Query Neighborhood Hits	263	Target Neighborhood Hits	255	Shared Neighborhood Hits	13
SwissProt Accessions	Q9DA19, Q3V2N9, Q4KL44, Q52KL9, Q5FW66	Gene names	Cir
Domain Architecture	No domain graphic available
Description	CBF1-interacting corepressor.

BRE1A_HUMAN
NC score	0.017461 (rank : 340)	θ value	0.47712 (rank : 71)
Query Neighborhood Hits	263	Target Neighborhood Hits	1071	Shared Neighborhood Hits	33
SwissProt Accessions	Q5VTR2, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83	Gene names	RNF20, BRE1A
Domain Architecture	No domain graphic available
Description	Ubiquitin-protein ligase BRE1A (EC 6.3.2.-) (BRE1-A) (hBRE1) (RING finger protein 20).

SDCG1_MOUSE
NC score	0.016683 (rank : 341)	θ value	6.88961 (rank : 234)
Query Neighborhood Hits	263	Target Neighborhood Hits	168	Shared Neighborhood Hits	13
SwissProt Accessions	Q8CCP0, Q66JX6, Q8C9R6, Q8CA65, Q8JZT9, Q8R072, Q9CW30, Q9CYB8, Q9D4A9	Gene names	Sdccag1
Domain Architecture
Description	Serologically defined colon cancer antigen 1.

SMBP2_HUMAN
NC score	0.016611 (rank : 342)	θ value	3.0926 (rank : 175)
Query Neighborhood Hits	263	Target Neighborhood Hits	107	Shared Neighborhood Hits	10
SwissProt Accessions	P38935, Q00443, Q14177	Gene names	IGHMBP2, SMBP2, SMUBP2
Domain Architecture
Description	DNA-binding protein SMUBP-2 (EC 3.6.1.-) (ATP-dependent helicase IGHMBP2) (Immunoglobulin mu-binding protein 2) (SMUBP-2) (Glial factor 1) (GF-1).

TULP1_MOUSE
NC score	0.015742 (rank : 343)	θ value	5.27518 (rank : 211)
Query Neighborhood Hits	263	Target Neighborhood Hits	146	Shared Neighborhood Hits	11
SwissProt Accessions	Q9Z273	Gene names	Tulp1
Domain Architecture
Description	Tubby-related protein 1 (Tubby-like protein 1).

TLE1_HUMAN
NC score	0.014797 (rank : 344)	θ value	8.99809 (rank : 258)
Query Neighborhood Hits	263	Target Neighborhood Hits	485	Shared Neighborhood Hits	26
SwissProt Accessions	Q04724, Q5T3G4, Q969V9	Gene names	TLE1
Domain Architecture
Description	Transducin-like enhancer protein 1 (ESG1) (E(Sp1) homolog).

WDR67_HUMAN
NC score	0.014420 (rank : 345)	θ value	8.99809 (rank : 262)
Query Neighborhood Hits	263	Target Neighborhood Hits	782	Shared Neighborhood Hits	32
SwissProt Accessions	Q96DN5, Q3MIR6, Q8TBP9	Gene names	WDR67
Domain Architecture	No domain graphic available
Description	WD repeat protein 67.

TLE4_HUMAN
NC score	0.014119 (rank : 346)	θ value	6.88961 (rank : 237)
Query Neighborhood Hits	263	Target Neighborhood Hits	477	Shared Neighborhood Hits	30
SwissProt Accessions	Q04727, Q5T1Y2, Q9BZ07, Q9BZ08, Q9BZ09, Q9NSL3, Q9ULF9	Gene names	TLE4, KIAA1261
Domain Architecture
Description	Transducin-like enhancer protein 4.

JHD1B_MOUSE
NC score	0.014009 (rank : 347)	θ value	3.0926 (rank : 162)
Query Neighborhood Hits	263	Target Neighborhood Hits	214	Shared Neighborhood Hits	13
SwissProt Accessions	Q6P1G2, Q3V396, Q6PFD0, Q6ZPE8, Q9CSF7, Q9QZN6	Gene names	Fbxl10, Fbl10, Jhdm1b, Kiaa3014
Domain Architecture	No domain graphic available
Description	JmjC domain-containing histone demethylation protein 1B (EC 1.14.11.-) (F-box/LRR-repeat protein 10) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10).

CTGE5_HUMAN
NC score	0.013961 (rank : 348)	θ value	1.81305 (rank : 121)
Query Neighborhood Hits	263	Target Neighborhood Hits	800	Shared Neighborhood Hits	31
SwissProt Accessions	O15320, O00169, Q6P2R8, Q8IX92, Q8IX93	Gene names	CTAGE5, MEA11, MEA6, MGEA11, MGEA6
Domain Architecture
Description	Cutaneous T-cell lymphoma-associated antigen 5 (cTAGE-5 protein) (cTAGE family member 5) (Meningioma-expressed antigen 6/11).

PLCB1_MOUSE
NC score	0.013336 (rank : 349)	θ value	6.88961 (rank : 230)
Query Neighborhood Hits	263	Target Neighborhood Hits	531	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Z1B3, Q62075, Q8K5A5, Q8K5A6, Q9Z0E5, Q9Z2T5	Gene names	Plcb1, Plcb
Domain Architecture
Description	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 1 (EC 3.1.4.11) (Phosphoinositide phospholipase C) (Phospholipase C- beta-1) (PLC-beta-1) (PLC-I) (PLC-154).

TLE4_MOUSE
NC score	0.013257 (rank : 350)	θ value	8.99809 (rank : 259)
Query Neighborhood Hits	263	Target Neighborhood Hits	482	Shared Neighborhood Hits	31
SwissProt Accessions	Q62441, Q9JKQ9	Gene names	Tle4, Grg4
Domain Architecture
Description	Transducin-like enhancer protein 4 (Groucho-related protein 4) (Grg- 4).

I17RD_MOUSE
NC score	0.012368 (rank : 351)	θ value	6.88961 (rank : 222)
Query Neighborhood Hits	263	Target Neighborhood Hits	11	Shared Neighborhood Hits	2
SwissProt Accessions	Q8JZL1, Q8K447, Q8R5J8	Gene names	Il17rd, Il17rlm, Sef
Domain Architecture	No domain graphic available
Description	Interleukin-17 receptor D precursor (IL-17 receptor D) (IL-17RD) (Interleukin-17D receptor) (IL-17D receptor) (Interleukin-17 receptor- like protein) (Sef homolog) (mSef).

DDX50_MOUSE
NC score	0.012285 (rank : 352)	θ value	1.06291 (rank : 98)
Query Neighborhood Hits	263	Target Neighborhood Hits	137	Shared Neighborhood Hits	6
SwissProt Accessions	Q99MJ9	Gene names	Ddx50
Domain Architecture	No domain graphic available
Description	ATP-dependent RNA helicase DDX50 (EC 3.6.1.-) (DEAD box protein 50) (Nucleolar protein Gu2) (Gu-beta).

MA2A1_MOUSE
NC score	0.011930 (rank : 353)	θ value	4.03905 (rank : 187)
Query Neighborhood Hits	263	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	P27046	Gene names	Man2a1, Mana2
Domain Architecture
Description	Alpha-mannosidase 2 (EC 3.2.1.114) (Alpha-mannosidase II) (Mannosyl- oligosaccharide 1,3-1,6-alpha-mannosidase) (MAN II) (Golgi alpha- mannosidase II) (Mannosidase alpha class 2A member 1) (AMAN II).

NEMO_MOUSE
NC score	0.011792 (rank : 354)	θ value	6.88961 (rank : 227)
Query Neighborhood Hits	263	Target Neighborhood Hits	658	Shared Neighborhood Hits	27
SwissProt Accessions	O88522	Gene names	Ikbkg, Nemo
Domain Architecture	No domain graphic available
Description	NF-kappa-B essential modulator (NEMO) (NF-kappa-B essential modifier) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (IkB kinase subunit gamma) (I-kappa-B kinase gamma) (IKK-gamma) (IKKG) (IkB kinase-associated protein 1) (IKKAP1) (mFIP-3).

NOL10_MOUSE
NC score	0.011355 (rank : 355)	θ value	6.88961 (rank : 228)
Query Neighborhood Hits	263	Target Neighborhood Hits	206	Shared Neighborhood Hits	7
SwissProt Accessions	Q5RJG1	Gene names	Nol10, Gm67
Domain Architecture	No domain graphic available
Description	Nucleolar protein 10.

NFL_HUMAN
NC score	0.010889 (rank : 356)	θ value	8.99809 (rank : 250)
Query Neighborhood Hits	263	Target Neighborhood Hits	666	Shared Neighborhood Hits	21
SwissProt Accessions	P07196, Q16154, Q8IU72	Gene names	NEFL, NF68, NFL
Domain Architecture
Description	Neurofilament triplet L protein (68 kDa neurofilament protein) (Neurofilament light polypeptide) (NF-L).

DACH2_HUMAN
NC score	0.010243 (rank : 357)	θ value	6.88961 (rank : 219)
Query Neighborhood Hits	263	Target Neighborhood Hits	122	Shared Neighborhood Hits	5
SwissProt Accessions	Q96NX9, Q8NAY3, Q8ND17, Q96N55	Gene names	DACH2
Domain Architecture
Description	Dachshund homolog 2 (Dach2).

PRGR_MOUSE
NC score	0.010179 (rank : 358)	θ value	8.99809 (rank : 252)
Query Neighborhood Hits	263	Target Neighborhood Hits	286	Shared Neighborhood Hits	27
SwissProt Accessions	Q00175	Gene names	Pgr, Nr3c3, Pr
Domain Architecture
Description	Progesterone receptor (PR).

KLDC1_MOUSE
NC score	0.010111 (rank : 359)	θ value	5.27518 (rank : 200)
Query Neighborhood Hits	263	Target Neighborhood Hits	68	Shared Neighborhood Hits	2
SwissProt Accessions	Q80YG3	Gene names	Klhdc1
Domain Architecture	No domain graphic available
Description	Kelch domain-containing protein 1.

CSF2R_HUMAN
NC score	0.009836 (rank : 360)	θ value	8.99809 (rank : 243)
Query Neighborhood Hits	263	Target Neighborhood Hits	22	Shared Neighborhood Hits	2
SwissProt Accessions	P15509, O00207, Q14429, Q14430, Q14431, Q16564	Gene names	CSF2RA, CSF2R
Domain Architecture	No domain graphic available
Description	Granulocyte-macrophage colony-stimulating factor receptor alpha chain precursor (GM-CSF-R-alpha) (GMR) (CD116 antigen) (CDw116).

REST_MOUSE
NC score	0.009637 (rank : 361)	θ value	6.88961 (rank : 233)
Query Neighborhood Hits	263	Target Neighborhood Hits	1506	Shared Neighborhood Hits	52
SwissProt Accessions	Q922J3, Q571L7	Gene names	Rsn, Kiaa4046
Domain Architecture	No domain graphic available
Description	Restin.

KI21A_HUMAN
NC score	0.007571 (rank : 362)	θ value	8.99809 (rank : 249)
Query Neighborhood Hits	263	Target Neighborhood Hits	1543	Shared Neighborhood Hits	51
SwissProt Accessions	Q7Z4S6, Q6UKL9, Q7Z668, Q86WZ5, Q8IVZ8, Q9C0F5, Q9NXU4, Q9Y590	Gene names	KIF21A, KIAA1708, KIF2
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A (Kinesin-like protein KIF2) (NY-REN-62 antigen).

FYCO1_MOUSE
NC score	0.005543 (rank : 363)	θ value	8.99809 (rank : 248)
Query Neighborhood Hits	263	Target Neighborhood Hits	1059	Shared Neighborhood Hits	26
SwissProt Accessions	Q8VDC1, Q3V385, Q7TMT0, Q8BJN2	Gene names	Fyco1
Domain Architecture	No domain graphic available
Description	FYVE and coiled-coil domain-containing protein 1.

ZBTB5_MOUSE
NC score	0.004886 (rank : 364)	θ value	0.813845 (rank : 94)
Query Neighborhood Hits	263	Target Neighborhood Hits	801	Shared Neighborhood Hits	9
SwissProt Accessions	Q7TQG0, Q3TVR7, Q6GV09, Q8BIB5	Gene names	Zbtb5, Kiaa0354
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 5 (Transcription factor ZNF-POZ).

INSM1_MOUSE
NC score	0.003382 (rank : 365)	θ value	6.88961 (rank : 223)
Query Neighborhood Hits	263	Target Neighborhood Hits	678	Shared Neighborhood Hits	14
SwissProt Accessions	Q63ZV0, Q9Z113	Gene names	Insm1, Ia1
Domain Architecture	No domain graphic available
Description	Insulinoma-associated protein 1 (Zinc finger protein IA-1).

SUHW3_MOUSE
NC score	0.003087 (rank : 366)	θ value	3.0926 (rank : 176)
Query Neighborhood Hits	263	Target Neighborhood Hits	697	Shared Neighborhood Hits	10
SwissProt Accessions	Q6P3Y5, Q6ZPM2, Q8K145	Gene names	Suhw3, Kiaa1584
Domain Architecture	No domain graphic available
Description	Suppressor of hairy wing homolog 3.

ZBTB5_HUMAN
NC score	0.002288 (rank : 367)	θ value	8.99809 (rank : 263)
Query Neighborhood Hits	263	Target Neighborhood Hits	811	Shared Neighborhood Hits	12
SwissProt Accessions	O15062	Gene names	ZBTB5, KIAA0354
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 5.

TCF8_MOUSE
NC score	0.002080 (rank : 368)	θ value	4.03905 (rank : 191)
Query Neighborhood Hits	263	Target Neighborhood Hits	1067	Shared Neighborhood Hits	32
SwissProt Accessions	Q64318, Q62519	Gene names	Tcf8, Zfhx1a, Zfx1a, Zfx1ha
Domain Architecture
Description	Transcription factor 8 (Zinc finger homeobox protein 1a) (MEB1) (Delta EF1).

ZN358_HUMAN
NC score	-0.000231 (rank : 369)	θ value	5.27518 (rank : 212)
Query Neighborhood Hits	263	Target Neighborhood Hits	840	Shared Neighborhood Hits	28
SwissProt Accessions	Q9NW07, Q9BTM7	Gene names	ZNF358
Domain Architecture
Description	Zinc finger protein 358.

ZN473_MOUSE
NC score	-0.001396 (rank : 370)	θ value	1.81305 (rank : 132)
Query Neighborhood Hits	263	Target Neighborhood Hits	824	Shared Neighborhood Hits	17
SwissProt Accessions	Q8BI67, Q8BI98, Q8BIB7	Gene names	Znf473, Zfp100, Zfp473
Domain Architecture	No domain graphic available
Description	Zinc finger protein 473 homolog (Zinc finger protein 100) (Zfp-100).

ZBT17_MOUSE
NC score	-0.002211 (rank : 371)	θ value	6.88961 (rank : 238)
Query Neighborhood Hits	263	Target Neighborhood Hits	940	Shared Neighborhood Hits	17
SwissProt Accessions	Q60821, Q60699	Gene names	Zbtb17, Zfp100, Znf151
Domain Architecture
Description	Zinc finger and BTB domain-containing protein 17 (Zinc finger protein 151) (Zinc finger protein 100) (Zfp-100) (Polyomavirus late initiator promoter-binding protein) (LP-1) (Zinc finger protein Z13).

ZFP38_HUMAN
NC score	-0.002232 (rank : 372)	θ value	4.03905 (rank : 192)
Query Neighborhood Hits	263	Target Neighborhood Hits	766	Shared Neighborhood Hits	10
SwissProt Accessions	Q9Y5A6, Q9H0B5	Gene names	ZNF38, ZFP38, ZSCAN21
Domain Architecture
Description	Zinc finger protein 38 homolog (Zfp-38) (Zinc finger and SCAN domain- containing protein 21) (NY-REN-21 antigen).

ACM4_MOUSE
NC score	-0.002867 (rank : 373)	θ value	6.88961 (rank : 214)
Query Neighborhood Hits	263	Target Neighborhood Hits	894	Shared Neighborhood Hits	7
SwissProt Accessions	P32211, Q64056	Gene names	Chrm4, Chrm-4
Domain Architecture
Description	Muscarinic acetylcholine receptor M4 (Mm4 mAChR).