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Network neighborhood for query Sequence : SMAD5_MOUSE

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SMAD5_MOUSE
SwissProt Accessions	P97454, P70341, Q810K0	Gene names	Smad5, Madh5, Msmad5
Domain Architecture
Description	Mothers against decapentaplegic homolog 5 (SMAD 5) (Mothers against DPP homolog 5) (Smad5) (mSmad5) (Dwarfin-C) (Dwf-C).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SMAD1_HUMAN
θ value	0 (rank : 1)	NC score	0.993660 (rank : 4)
Query Neighborhood Hits	74	Target Neighborhood Hits	59	Shared Neighborhood Hits	33
SwissProt Accessions	Q15797, Q16636	Gene names	SMAD1, BSP1, MADH1, MADR1
Domain Architecture
Description	Mothers against decapentaplegic homolog 1 (SMAD 1) (Mothers against DPP homolog 1) (Mad-related protein 1) (Transforming growth factor- beta signaling protein 1) (BSP-1) (hSMAD1) (JV4-1).

SMAD1_MOUSE
θ value	0 (rank : 2)	NC score	0.993891 (rank : 3)
Query Neighborhood Hits	74	Target Neighborhood Hits	56	Shared Neighborhood Hits	33
SwissProt Accessions	P70340, P70442, Q9CYK6	Gene names	Smad1, Madh1, Madr1
Domain Architecture
Description	Mothers against decapentaplegic homolog 1 (SMAD 1) (Mothers against DPP homolog 1) (Mad-related protein 1) (Mothers-against-DPP-related 1) (mMad1) (Dwarfin-A) (Dwf-A).

SMAD5_HUMAN
θ value	0 (rank : 3)	NC score	0.998440 (rank : 2)
Query Neighborhood Hits	74	Target Neighborhood Hits	57	Shared Neighborhood Hits	52
SwissProt Accessions	Q99717, O14688, Q15798, Q9UQA1	Gene names	SMAD5, MADH5
Domain Architecture
Description	Mothers against decapentaplegic homolog 5 (SMAD 5) (Mothers against DPP homolog 5) (Smad5) (hSmad5) (JV5-1).

SMAD5_MOUSE
θ value	0 (rank : 4)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	74
SwissProt Accessions	P97454, P70341, Q810K0	Gene names	Smad5, Madh5, Msmad5
Domain Architecture
Description	Mothers against decapentaplegic homolog 5 (SMAD 5) (Mothers against DPP homolog 5) (Smad5) (mSmad5) (Dwarfin-C) (Dwf-C).

SMAD9_HUMAN
θ value	0 (rank : 5)	NC score	0.992519 (rank : 5)
Query Neighborhood Hits	74	Target Neighborhood Hits	48	Shared Neighborhood Hits	19
SwissProt Accessions	O15198, O14989	Gene names	SMAD9, MADH6, MADH9
Domain Architecture
Description	Mothers against decapentaplegic homolog 9 (SMAD 9) (Mothers against DPP homolog 9) (Smad9) (Madh6).

SMAD9_MOUSE
θ value	0 (rank : 6)	NC score	0.988495 (rank : 6)
Query Neighborhood Hits	74	Target Neighborhood Hits	75	Shared Neighborhood Hits	20
SwissProt Accessions	Q9JIW5, Q8CFF9	Gene names	Smad9, Madh8, Madh9, Smad8
Domain Architecture
Description	Mothers against decapentaplegic homolog 9 (SMAD 9) (Mothers against DPP homolog 9) (Smad9) (Smad8).

SMAD3_HUMAN
θ value	9.85132e-148 (rank : 7)	NC score	0.985177 (rank : 7)
Query Neighborhood Hits	74	Target Neighborhood Hits	25	Shared Neighborhood Hits	18
SwissProt Accessions	P84022, O09064, O09144, O14510, O35273, Q92940, Q93002, Q9GKR4	Gene names	SMAD3, MADH3
Domain Architecture
Description	Mothers against decapentaplegic homolog 3 (SMAD 3) (Mothers against DPP homolog 3) (Mad3) (hMAD-3) (JV15-2) (hSMAD3).

SMAD3_MOUSE
θ value	9.85132e-148 (rank : 8)	NC score	0.985177 (rank : 8)
Query Neighborhood Hits	74	Target Neighborhood Hits	25	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BUN5, O09064, O09144, O14510, O35273, Q8BX84, Q92940, Q93002, Q9GKR4	Gene names	Smad3, Madh3
Domain Architecture
Description	Mothers against decapentaplegic homolog 3 (SMAD 3) (Mothers against DPP homolog 3) (Mad3) (mMad3).

SMAD2_HUMAN
θ value	1.4755e-135 (rank : 9)	NC score	0.981667 (rank : 10)
Query Neighborhood Hits	74	Target Neighborhood Hits	25	Shared Neighborhood Hits	16
SwissProt Accessions	Q15796	Gene names	SMAD2, MADH2, MADR2
Domain Architecture
Description	Mothers against decapentaplegic homolog 2 (SMAD 2) (Mothers against DPP homolog 2) (Mad-related protein 2) (hMAD-2) (JV18-1) (hSMAD2).

SMAD2_MOUSE
θ value	1.4755e-135 (rank : 10)	NC score	0.981670 (rank : 9)
Query Neighborhood Hits	74	Target Neighborhood Hits	25	Shared Neighborhood Hits	16
SwissProt Accessions	Q62432, Q9D8P6	Gene names	Smad2, Madh2, Madr2
Domain Architecture
Description	Mothers against decapentaplegic homolog 2 (SMAD 2) (Mothers against DPP homolog 2) (Mad-related protein 2) (mMad2).

SMAD4_MOUSE
θ value	1.71981e-67 (rank : 11)	NC score	0.923047 (rank : 12)
Query Neighborhood Hits	74	Target Neighborhood Hits	101	Shared Neighborhood Hits	18
SwissProt Accessions	P97471, Q9CW56	Gene names	Smad4, Dpc4, Madh4
Domain Architecture
Description	Mothers against decapentaplegic homolog 4 (SMAD 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4 homolog) (Smad4).

SMAD4_HUMAN
θ value	7.2256e-66 (rank : 12)	NC score	0.924655 (rank : 11)
Query Neighborhood Hits	74	Target Neighborhood Hits	72	Shared Neighborhood Hits	16
SwissProt Accessions	Q13485	Gene names	SMAD4, DPC4, MADH4
Domain Architecture
Description	Mothers against decapentaplegic homolog 4 (SMAD 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (hSMAD4).

SMAD6_MOUSE
θ value	5.07402e-19 (rank : 13)	NC score	0.766732 (rank : 13)
Query Neighborhood Hits	74	Target Neighborhood Hits	22	Shared Neighborhood Hits	16
SwissProt Accessions	O35182, Q9CW62	Gene names	Smad6, Madh6, Madh7, Msmad6
Domain Architecture
Description	Mothers against decapentaplegic homolog 6 (SMAD 6) (Mothers against DPP homolog 6) (Smad6) (Mad homolog 7).

SMAD6_HUMAN
θ value	1.47631e-18 (rank : 14)	NC score	0.763852 (rank : 14)
Query Neighborhood Hits	74	Target Neighborhood Hits	31	Shared Neighborhood Hits	16
SwissProt Accessions	O43541, O43654, Q15799, Q9UKZ3	Gene names	SMAD6, MADH6
Domain Architecture
Description	Mothers against decapentaplegic homolog 6 (SMAD 6) (Mothers against DPP homolog 6) (Smad6) (hSMAD6).

SMAD7_HUMAN
θ value	3.40345e-15 (rank : 15)	NC score	0.748847 (rank : 16)
Query Neighborhood Hits	74	Target Neighborhood Hits	20	Shared Neighborhood Hits	16
SwissProt Accessions	O15105, O14740, Q6DK23	Gene names	SMAD7, MADH7, MADH8
Domain Architecture
Description	Mothers against decapentaplegic homolog 7 (SMAD 7) (Mothers against DPP homolog 7) (Smad7) (hSMAD7).

SMAD7_MOUSE
θ value	3.40345e-15 (rank : 16)	NC score	0.749642 (rank : 15)
Query Neighborhood Hits	74	Target Neighborhood Hits	18	Shared Neighborhood Hits	16
SwissProt Accessions	O35253, O88709	Gene names	Smad7, Madh7
Domain Architecture
Description	Mothers against decapentaplegic homolog 7 (SMAD 7) (Mothers against DPP homolog 7) (Smad7) (Madh8).

CRSP2_HUMAN
θ value	0.00390308 (rank : 17)	NC score	0.103228 (rank : 17)
Query Neighborhood Hits	74	Target Neighborhood Hits	380	Shared Neighborhood Hits	14
SwissProt Accessions	O60244, Q9UNB3	Gene names	CRSP2, ARC150, DRIP150, EXLM1, TRAP170
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 2 (Cofactor required for Sp1 transcriptional activation subunit 2) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Activator-recruited cofactor 150 kDa component) (ARC150).

LCP2_HUMAN
θ value	0.0148317 (rank : 18)	NC score	0.054148 (rank : 18)
Query Neighborhood Hits	74	Target Neighborhood Hits	531	Shared Neighborhood Hits	19
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

MLL3_MOUSE
θ value	0.125558 (rank : 19)	NC score	0.027994 (rank : 27)
Query Neighborhood Hits	74	Target Neighborhood Hits	1399	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

CSKI1_MOUSE
θ value	0.163984 (rank : 20)	NC score	0.023015 (rank : 32)
Query Neighborhood Hits	74	Target Neighborhood Hits	1031	Shared Neighborhood Hits	24
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

FOXJ1_MOUSE
θ value	0.163984 (rank : 21)	NC score	0.019223 (rank : 37)
Query Neighborhood Hits	74	Target Neighborhood Hits	209	Shared Neighborhood Hits	5
SwissProt Accessions	Q61660	Gene names	Foxj1, Fkhl13, Hfh4
Domain Architecture
Description	Forkhead box protein J1 (Forkhead-related protein FKHL13) (Hepatocyte nuclear factor 3 forkhead homolog 4) (HFH-4).

EVX1_HUMAN
θ value	0.365318 (rank : 22)	NC score	0.016247 (rank : 45)
Query Neighborhood Hits	74	Target Neighborhood Hits	349	Shared Neighborhood Hits	6
SwissProt Accessions	P49640	Gene names	EVX1
Domain Architecture
Description	Homeobox even-skipped homolog protein 1 (EVX-1).

EVX1_MOUSE
θ value	0.365318 (rank : 23)	NC score	0.016341 (rank : 44)
Query Neighborhood Hits	74	Target Neighborhood Hits	350	Shared Neighborhood Hits	8
SwissProt Accessions	P23683	Gene names	Evx1
Domain Architecture
Description	Homeobox even-skipped homolog protein 1 (EVX-1).

FAT2_HUMAN
θ value	0.47712 (rank : 24)	NC score	0.010338 (rank : 59)
Query Neighborhood Hits	74	Target Neighborhood Hits	507	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NYQ8, O75091, Q9NSR7	Gene names	FAT2, CDHF8, KIAA0811, MEGF1
Domain Architecture
Description	Protocadherin Fat 2 precursor (hFat2) (Multiple epidermal growth factor-like domains 1).

KBTB4_HUMAN
θ value	0.47712 (rank : 25)	NC score	0.022332 (rank : 34)
Query Neighborhood Hits	74	Target Neighborhood Hits	187	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NVX7, Q6IA85, Q9BUC3, Q9NV76	Gene names	KBTBD4, BKLHD4
Domain Architecture
Description	Kelch repeat and BTB domain-containing protein 4 (BTB and kelch domain-containing protein 4).

LPP_HUMAN
θ value	0.47712 (rank : 26)	NC score	0.022400 (rank : 33)
Query Neighborhood Hits	74	Target Neighborhood Hits	775	Shared Neighborhood Hits	23
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

NIPBL_HUMAN
θ value	0.47712 (rank : 27)	NC score	0.017927 (rank : 40)
Query Neighborhood Hits	74	Target Neighborhood Hits	1311	Shared Neighborhood Hits	16
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

NPBL_MOUSE
θ value	0.47712 (rank : 28)	NC score	0.020829 (rank : 35)
Query Neighborhood Hits	74	Target Neighborhood Hits	1041	Shared Neighborhood Hits	14
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

NCOA6_MOUSE
θ value	0.62314 (rank : 29)	NC score	0.045827 (rank : 20)
Query Neighborhood Hits	74	Target Neighborhood Hits	1076	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

ARI1B_HUMAN
θ value	0.813845 (rank : 30)	NC score	0.028250 (rank : 26)
Query Neighborhood Hits	74	Target Neighborhood Hits	567	Shared Neighborhood Hits	23
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

IRAK3_MOUSE
θ value	0.813845 (rank : 31)	NC score	0.006564 (rank : 65)
Query Neighborhood Hits	74	Target Neighborhood Hits	628	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

TCGAP_HUMAN
θ value	0.813845 (rank : 32)	NC score	0.009330 (rank : 61)
Query Neighborhood Hits	74	Target Neighborhood Hits	872	Shared Neighborhood Hits	19
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

MLL3_HUMAN
θ value	1.06291 (rank : 33)	NC score	0.023381 (rank : 30)
Query Neighborhood Hits	74	Target Neighborhood Hits	1644	Shared Neighborhood Hits	28
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

BCAR1_HUMAN
θ value	1.38821 (rank : 34)	NC score	0.014016 (rank : 47)
Query Neighborhood Hits	74	Target Neighborhood Hits	554	Shared Neighborhood Hits	22
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

IRF4_HUMAN
θ value	1.38821 (rank : 35)	NC score	0.048131 (rank : 19)
Query Neighborhood Hits	74	Target Neighborhood Hits	31	Shared Neighborhood Hits	6
SwissProt Accessions	Q15306, Q99660	Gene names	IRF4, MUM1
Domain Architecture
Description	Interferon regulatory factor 4 (IRF-4) (Lymphocyte-specific interferon regulatory factor) (LSIRF) (NF-EM5) (Multiple myeloma oncogene 1).

SUSD4_MOUSE
θ value	1.38821 (rank : 36)	NC score	0.013869 (rank : 48)
Query Neighborhood Hits	74	Target Neighborhood Hits	122	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BH32, Q8VC43	Gene names	Susd4
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 4 precursor.

BOP1_MOUSE
θ value	1.81305 (rank : 37)	NC score	0.013287 (rank : 49)
Query Neighborhood Hits	74	Target Neighborhood Hits	267	Shared Neighborhood Hits	4
SwissProt Accessions	P97452, Q3TK87, Q91X31	Gene names	Bop1
Domain Architecture
Description	Ribosome biogenesis protein BOP1 (Block of proliferation 1 protein).

DAZ1_HUMAN
θ value	2.36792 (rank : 38)	NC score	0.040880 (rank : 24)
Query Neighborhood Hits	74	Target Neighborhood Hits	192	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NQZ3, Q9NQZ4	Gene names	DAZ1, DAZ
Domain Architecture
Description	Deleted in azoospermia protein 1.

DAZ2_HUMAN
θ value	2.36792 (rank : 39)	NC score	0.041461 (rank : 22)
Query Neighborhood Hits	74	Target Neighborhood Hits	193	Shared Neighborhood Hits	10
SwissProt Accessions	Q13117, Q96P41, Q9NR91	Gene names	DAZ2
Domain Architecture
Description	Deleted in azoospermia protein 2.

DAZ3_HUMAN
θ value	2.36792 (rank : 40)	NC score	0.041561 (rank : 21)
Query Neighborhood Hits	74	Target Neighborhood Hits	188	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NR90	Gene names	DAZ3
Domain Architecture
Description	Deleted in azoospermia protein 3.

DAZ4_HUMAN
θ value	2.36792 (rank : 41)	NC score	0.041041 (rank : 23)
Query Neighborhood Hits	74	Target Neighborhood Hits	192	Shared Neighborhood Hits	10
SwissProt Accessions	Q86SG3, Q9NR88, Q9NR89	Gene names	DAZ4
Domain Architecture
Description	Deleted in azoospermia protein 4.

KBTB4_MOUSE
θ value	2.36792 (rank : 42)	NC score	0.012721 (rank : 55)
Query Neighborhood Hits	74	Target Neighborhood Hits	182	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R179, Q9CQX1	Gene names	Kbtbd4, Bklhd4
Domain Architecture
Description	Kelch repeat and BTB domain-containing protein 4 (BTB and kelch domain-containing protein 4).

RGS3_HUMAN
θ value	2.36792 (rank : 43)	NC score	0.010130 (rank : 60)
Query Neighborhood Hits	74	Target Neighborhood Hits	1375	Shared Neighborhood Hits	24
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

K0256_HUMAN
θ value	3.0926 (rank : 44)	NC score	0.023888 (rank : 28)
Query Neighborhood Hits	74	Target Neighborhood Hits	73	Shared Neighborhood Hits	5
SwissProt Accessions	Q93073, Q8N767	Gene names	KIAA0256
Domain Architecture	No domain graphic available
Description	Protein KIAA0256.

K0256_MOUSE
θ value	3.0926 (rank : 45)	NC score	0.023318 (rank : 31)
Query Neighborhood Hits	74	Target Neighborhood Hits	121	Shared Neighborhood Hits	5
SwissProt Accessions	Q6A098	Gene names	Kiaa0256
Domain Architecture	No domain graphic available
Description	Protein KIAA0256.

K1543_MOUSE
θ value	3.0926 (rank : 46)	NC score	0.017987 (rank : 39)
Query Neighborhood Hits	74	Target Neighborhood Hits	497	Shared Neighborhood Hits	21
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

TSKS_MOUSE
θ value	3.0926 (rank : 47)	NC score	0.018348 (rank : 38)
Query Neighborhood Hits	74	Target Neighborhood Hits	188	Shared Neighborhood Hits	6
SwissProt Accessions	O54887	Gene names	Stk22s1, Tsks
Domain Architecture	No domain graphic available
Description	Testis-specific serine kinase substrate (Testis-specific kinase substrate) (STK22 substrate 1).

NACAM_MOUSE
θ value	4.03905 (rank : 48)	NC score	0.012911 (rank : 52)
Query Neighborhood Hits	74	Target Neighborhood Hits	1866	Shared Neighborhood Hits	32
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

NALP1_HUMAN
θ value	4.03905 (rank : 49)	NC score	0.005239 (rank : 68)
Query Neighborhood Hits	74	Target Neighborhood Hits	138	Shared Neighborhood Hits	6
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

NUFP1_HUMAN
θ value	4.03905 (rank : 50)	NC score	0.012787 (rank : 54)
Query Neighborhood Hits	74	Target Neighborhood Hits	193	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UHK0, Q8WVM5, Q96SG1	Gene names	NUFIP1
Domain Architecture	No domain graphic available
Description	Nuclear fragile X mental retardation-interacting protein 1 (Nuclear FMRP-interacting protein 1).

PSL1_HUMAN
θ value	4.03905 (rank : 51)	NC score	0.012520 (rank : 56)
Query Neighborhood Hits	74	Target Neighborhood Hits	650	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

RGS3_MOUSE
θ value	4.03905 (rank : 52)	NC score	0.008682 (rank : 62)
Query Neighborhood Hits	74	Target Neighborhood Hits	1621	Shared Neighborhood Hits	28
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

TENS4_HUMAN
θ value	4.03905 (rank : 53)	NC score	0.016453 (rank : 43)
Query Neighborhood Hits	74	Target Neighborhood Hits	214	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

TSKS_HUMAN
θ value	4.03905 (rank : 54)	NC score	0.016632 (rank : 42)
Query Neighborhood Hits	74	Target Neighborhood Hits	220	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UJT2, Q8WXJ0	Gene names	STK22S1, TSKS, TSKS1
Domain Architecture	No domain graphic available
Description	Testis-specific serine kinase substrate (Testis-specific kinase substrate) (STK22 substrate 1).

ZIMP7_MOUSE
θ value	4.03905 (rank : 55)	NC score	0.012891 (rank : 53)
Query Neighborhood Hits	74	Target Neighborhood Hits	566	Shared Neighborhood Hits	21
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

GP124_MOUSE
θ value	5.27518 (rank : 56)	NC score	0.002098 (rank : 72)
Query Neighborhood Hits	74	Target Neighborhood Hits	423	Shared Neighborhood Hits	7
SwissProt Accessions	Q91ZV8	Gene names	Gpr124, Tem5
Domain Architecture
Description	Probable G-protein coupled receptor 124 precursor (Tumor endothelial marker 5).

HRX_HUMAN
θ value	5.27518 (rank : 57)	NC score	0.017011 (rank : 41)
Query Neighborhood Hits	74	Target Neighborhood Hits	825	Shared Neighborhood Hits	20
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

IL16_MOUSE
θ value	5.27518 (rank : 58)	NC score	0.005745 (rank : 66)
Query Neighborhood Hits	74	Target Neighborhood Hits	189	Shared Neighborhood Hits	3
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

IRF7_HUMAN
θ value	5.27518 (rank : 59)	NC score	0.019669 (rank : 36)
Query Neighborhood Hits	74	Target Neighborhood Hits	73	Shared Neighborhood Hits	8
SwissProt Accessions	Q92985, O00331, O00332, O00333, O75924	Gene names	IRF7
Domain Architecture
Description	Interferon regulatory factor 7 (IRF-7).

ZIM10_HUMAN
θ value	5.27518 (rank : 60)	NC score	0.023858 (rank : 29)
Query Neighborhood Hits	74	Target Neighborhood Hits	577	Shared Neighborhood Hits	25
SwissProt Accessions	Q9ULJ6, Q7Z7E6	Gene names	RAI17, KIAA1224, ZIMP10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

ZO1_HUMAN
θ value	5.27518 (rank : 61)	NC score	0.004708 (rank : 69)
Query Neighborhood Hits	74	Target Neighborhood Hits	474	Shared Neighborhood Hits	13
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

CDON_MOUSE
θ value	6.88961 (rank : 62)	NC score	0.001828 (rank : 73)
Query Neighborhood Hits	74	Target Neighborhood Hits	410	Shared Neighborhood Hits	3
SwissProt Accessions	Q32MD9, O88971	Gene names	Cdon, Cdo
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

GNAS1_MOUSE
θ value	6.88961 (rank : 63)	NC score	0.008232 (rank : 63)
Query Neighborhood Hits	74	Target Neighborhood Hits	651	Shared Neighborhood Hits	20
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

HELZ_HUMAN
θ value	6.88961 (rank : 64)	NC score	0.013250 (rank : 50)
Query Neighborhood Hits	74	Target Neighborhood Hits	198	Shared Neighborhood Hits	13
SwissProt Accessions	P42694	Gene names	HELZ, KIAA0054
Domain Architecture	No domain graphic available
Description	Probable helicase with zinc-finger domain (EC 3.6.1.-).

KCNN3_HUMAN
θ value	6.88961 (rank : 65)	NC score	0.007230 (rank : 64)
Query Neighborhood Hits	74	Target Neighborhood Hits	216	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UGI6, O43517	Gene names	KCNN3, K3
Domain Architecture
Description	Small conductance calcium-activated potassium channel protein 3 (SK3) (SKCa3).

MISS_MOUSE
θ value	6.88961 (rank : 66)	NC score	0.035228 (rank : 25)
Query Neighborhood Hits	74	Target Neighborhood Hits	444	Shared Neighborhood Hits	22
SwissProt Accessions	Q9D7G9, Q7M749	Gene names	Mapk1ip1, Miss
Domain Architecture	No domain graphic available
Description	MAPK-interacting and spindle-stabilizing protein (Mitogen-activated protein kinase 1-interacting protein 1).

SUSD4_HUMAN
θ value	6.88961 (rank : 67)	NC score	0.011029 (rank : 58)
Query Neighborhood Hits	74	Target Neighborhood Hits	88	Shared Neighborhood Hits	3
SwissProt Accessions	Q5VX71, Q6UX62, Q9BSR0, Q9NWG0	Gene names	SUSD4
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 4 precursor.

CD248_MOUSE
θ value	8.99809 (rank : 68)	NC score	0.014753 (rank : 46)
Query Neighborhood Hits	74	Target Neighborhood Hits	578	Shared Neighborhood Hits	15
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

CSKI1_HUMAN
θ value	8.99809 (rank : 69)	NC score	0.013198 (rank : 51)
Query Neighborhood Hits	74	Target Neighborhood Hits	997	Shared Neighborhood Hits	24
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

DLX4_MOUSE
θ value	8.99809 (rank : 70)	NC score	0.002385 (rank : 71)
Query Neighborhood Hits	74	Target Neighborhood Hits	352	Shared Neighborhood Hits	6
SwissProt Accessions	P70436, Q3UM51, Q8R4I3	Gene names	Dlx4, Dlx7
Domain Architecture
Description	Homeobox protein DLX-4 (DLX-7).

GOGA1_HUMAN
θ value	8.99809 (rank : 71)	NC score	-0.000878 (rank : 74)
Query Neighborhood Hits	74	Target Neighborhood Hits	1222	Shared Neighborhood Hits	6
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).

HXD3_HUMAN
θ value	8.99809 (rank : 72)	NC score	0.003784 (rank : 70)
Query Neighborhood Hits	74	Target Neighborhood Hits	433	Shared Neighborhood Hits	12
SwissProt Accessions	P31249, Q99955, Q9BSC5	Gene names	HOXD3, HOX4A
Domain Architecture
Description	Homeobox protein Hox-D3 (Hox-4A).

IL3RB_MOUSE
θ value	8.99809 (rank : 73)	NC score	0.011077 (rank : 57)
Query Neighborhood Hits	74	Target Neighborhood Hits	355	Shared Neighborhood Hits	10
SwissProt Accessions	P26955	Gene names	Csf2rb, Aic2b, Csf2rb1, Il3rb1
Domain Architecture
Description	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen).

RB_MOUSE
θ value	8.99809 (rank : 74)	NC score	0.005407 (rank : 67)
Query Neighborhood Hits	74	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	P13405	Gene names	Rb1, Rb-1
Domain Architecture
Description	Retinoblastoma-associated protein (PP105) (RB).

Hits sorted by NC score

SMAD5_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 4)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	74
SwissProt Accessions	P97454, P70341, Q810K0	Gene names	Smad5, Madh5, Msmad5
Domain Architecture
Description	Mothers against decapentaplegic homolog 5 (SMAD 5) (Mothers against DPP homolog 5) (Smad5) (mSmad5) (Dwarfin-C) (Dwf-C).

SMAD5_HUMAN
NC score	0.998440 (rank : 2)	θ value	0 (rank : 3)
Query Neighborhood Hits	74	Target Neighborhood Hits	57	Shared Neighborhood Hits	52
SwissProt Accessions	Q99717, O14688, Q15798, Q9UQA1	Gene names	SMAD5, MADH5
Domain Architecture
Description	Mothers against decapentaplegic homolog 5 (SMAD 5) (Mothers against DPP homolog 5) (Smad5) (hSmad5) (JV5-1).

SMAD1_MOUSE
NC score	0.993891 (rank : 3)	θ value	0 (rank : 2)
Query Neighborhood Hits	74	Target Neighborhood Hits	56	Shared Neighborhood Hits	33
SwissProt Accessions	P70340, P70442, Q9CYK6	Gene names	Smad1, Madh1, Madr1
Domain Architecture
Description	Mothers against decapentaplegic homolog 1 (SMAD 1) (Mothers against DPP homolog 1) (Mad-related protein 1) (Mothers-against-DPP-related 1) (mMad1) (Dwarfin-A) (Dwf-A).

SMAD1_HUMAN
NC score	0.993660 (rank : 4)	θ value	0 (rank : 1)
Query Neighborhood Hits	74	Target Neighborhood Hits	59	Shared Neighborhood Hits	33
SwissProt Accessions	Q15797, Q16636	Gene names	SMAD1, BSP1, MADH1, MADR1
Domain Architecture
Description	Mothers against decapentaplegic homolog 1 (SMAD 1) (Mothers against DPP homolog 1) (Mad-related protein 1) (Transforming growth factor- beta signaling protein 1) (BSP-1) (hSMAD1) (JV4-1).

SMAD9_HUMAN
NC score	0.992519 (rank : 5)	θ value	0 (rank : 5)
Query Neighborhood Hits	74	Target Neighborhood Hits	48	Shared Neighborhood Hits	19
SwissProt Accessions	O15198, O14989	Gene names	SMAD9, MADH6, MADH9
Domain Architecture
Description	Mothers against decapentaplegic homolog 9 (SMAD 9) (Mothers against DPP homolog 9) (Smad9) (Madh6).

SMAD9_MOUSE
NC score	0.988495 (rank : 6)	θ value	0 (rank : 6)
Query Neighborhood Hits	74	Target Neighborhood Hits	75	Shared Neighborhood Hits	20
SwissProt Accessions	Q9JIW5, Q8CFF9	Gene names	Smad9, Madh8, Madh9, Smad8
Domain Architecture
Description	Mothers against decapentaplegic homolog 9 (SMAD 9) (Mothers against DPP homolog 9) (Smad9) (Smad8).

SMAD3_HUMAN
NC score	0.985177 (rank : 7)	θ value	9.85132e-148 (rank : 7)
Query Neighborhood Hits	74	Target Neighborhood Hits	25	Shared Neighborhood Hits	18
SwissProt Accessions	P84022, O09064, O09144, O14510, O35273, Q92940, Q93002, Q9GKR4	Gene names	SMAD3, MADH3
Domain Architecture
Description	Mothers against decapentaplegic homolog 3 (SMAD 3) (Mothers against DPP homolog 3) (Mad3) (hMAD-3) (JV15-2) (hSMAD3).

SMAD3_MOUSE
NC score	0.985177 (rank : 8)	θ value	9.85132e-148 (rank : 8)
Query Neighborhood Hits	74	Target Neighborhood Hits	25	Shared Neighborhood Hits	18
SwissProt Accessions	Q8BUN5, O09064, O09144, O14510, O35273, Q8BX84, Q92940, Q93002, Q9GKR4	Gene names	Smad3, Madh3
Domain Architecture
Description	Mothers against decapentaplegic homolog 3 (SMAD 3) (Mothers against DPP homolog 3) (Mad3) (mMad3).

SMAD2_MOUSE
NC score	0.981670 (rank : 9)	θ value	1.4755e-135 (rank : 10)
Query Neighborhood Hits	74	Target Neighborhood Hits	25	Shared Neighborhood Hits	16
SwissProt Accessions	Q62432, Q9D8P6	Gene names	Smad2, Madh2, Madr2
Domain Architecture
Description	Mothers against decapentaplegic homolog 2 (SMAD 2) (Mothers against DPP homolog 2) (Mad-related protein 2) (mMad2).

SMAD2_HUMAN
NC score	0.981667 (rank : 10)	θ value	1.4755e-135 (rank : 9)
Query Neighborhood Hits	74	Target Neighborhood Hits	25	Shared Neighborhood Hits	16
SwissProt Accessions	Q15796	Gene names	SMAD2, MADH2, MADR2
Domain Architecture
Description	Mothers against decapentaplegic homolog 2 (SMAD 2) (Mothers against DPP homolog 2) (Mad-related protein 2) (hMAD-2) (JV18-1) (hSMAD2).

SMAD4_HUMAN
NC score	0.924655 (rank : 11)	θ value	7.2256e-66 (rank : 12)
Query Neighborhood Hits	74	Target Neighborhood Hits	72	Shared Neighborhood Hits	16
SwissProt Accessions	Q13485	Gene names	SMAD4, DPC4, MADH4
Domain Architecture
Description	Mothers against decapentaplegic homolog 4 (SMAD 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (hSMAD4).

SMAD4_MOUSE
NC score	0.923047 (rank : 12)	θ value	1.71981e-67 (rank : 11)
Query Neighborhood Hits	74	Target Neighborhood Hits	101	Shared Neighborhood Hits	18
SwissProt Accessions	P97471, Q9CW56	Gene names	Smad4, Dpc4, Madh4
Domain Architecture
Description	Mothers against decapentaplegic homolog 4 (SMAD 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4 homolog) (Smad4).

SMAD6_MOUSE
NC score	0.766732 (rank : 13)	θ value	5.07402e-19 (rank : 13)
Query Neighborhood Hits	74	Target Neighborhood Hits	22	Shared Neighborhood Hits	16
SwissProt Accessions	O35182, Q9CW62	Gene names	Smad6, Madh6, Madh7, Msmad6
Domain Architecture
Description	Mothers against decapentaplegic homolog 6 (SMAD 6) (Mothers against DPP homolog 6) (Smad6) (Mad homolog 7).

SMAD6_HUMAN
NC score	0.763852 (rank : 14)	θ value	1.47631e-18 (rank : 14)
Query Neighborhood Hits	74	Target Neighborhood Hits	31	Shared Neighborhood Hits	16
SwissProt Accessions	O43541, O43654, Q15799, Q9UKZ3	Gene names	SMAD6, MADH6
Domain Architecture
Description	Mothers against decapentaplegic homolog 6 (SMAD 6) (Mothers against DPP homolog 6) (Smad6) (hSMAD6).

SMAD7_MOUSE
NC score	0.749642 (rank : 15)	θ value	3.40345e-15 (rank : 16)
Query Neighborhood Hits	74	Target Neighborhood Hits	18	Shared Neighborhood Hits	16
SwissProt Accessions	O35253, O88709	Gene names	Smad7, Madh7
Domain Architecture
Description	Mothers against decapentaplegic homolog 7 (SMAD 7) (Mothers against DPP homolog 7) (Smad7) (Madh8).

SMAD7_HUMAN
NC score	0.748847 (rank : 16)	θ value	3.40345e-15 (rank : 15)
Query Neighborhood Hits	74	Target Neighborhood Hits	20	Shared Neighborhood Hits	16
SwissProt Accessions	O15105, O14740, Q6DK23	Gene names	SMAD7, MADH7, MADH8
Domain Architecture
Description	Mothers against decapentaplegic homolog 7 (SMAD 7) (Mothers against DPP homolog 7) (Smad7) (hSMAD7).

CRSP2_HUMAN
NC score	0.103228 (rank : 17)	θ value	0.00390308 (rank : 17)
Query Neighborhood Hits	74	Target Neighborhood Hits	380	Shared Neighborhood Hits	14
SwissProt Accessions	O60244, Q9UNB3	Gene names	CRSP2, ARC150, DRIP150, EXLM1, TRAP170
Domain Architecture	No domain graphic available
Description	CRSP complex subunit 2 (Cofactor required for Sp1 transcriptional activation subunit 2) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Activator-recruited cofactor 150 kDa component) (ARC150).

LCP2_HUMAN
NC score	0.054148 (rank : 18)	θ value	0.0148317 (rank : 18)
Query Neighborhood Hits	74	Target Neighborhood Hits	531	Shared Neighborhood Hits	19
SwissProt Accessions	Q13094	Gene names	LCP2
Domain Architecture
Description	Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76).

IRF4_HUMAN
NC score	0.048131 (rank : 19)	θ value	1.38821 (rank : 35)
Query Neighborhood Hits	74	Target Neighborhood Hits	31	Shared Neighborhood Hits	6
SwissProt Accessions	Q15306, Q99660	Gene names	IRF4, MUM1
Domain Architecture
Description	Interferon regulatory factor 4 (IRF-4) (Lymphocyte-specific interferon regulatory factor) (LSIRF) (NF-EM5) (Multiple myeloma oncogene 1).

NCOA6_MOUSE
NC score	0.045827 (rank : 20)	θ value	0.62314 (rank : 29)
Query Neighborhood Hits	74	Target Neighborhood Hits	1076	Shared Neighborhood Hits	35
SwissProt Accessions	Q9JL19, Q9JLT9	Gene names	Ncoa6, Aib3, Prip, Rap250, Trbp
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC) (Thyroid hormone receptor-binding protein).

DAZ3_HUMAN
NC score	0.041561 (rank : 21)	θ value	2.36792 (rank : 40)
Query Neighborhood Hits	74	Target Neighborhood Hits	188	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NR90	Gene names	DAZ3
Domain Architecture
Description	Deleted in azoospermia protein 3.

DAZ2_HUMAN
NC score	0.041461 (rank : 22)	θ value	2.36792 (rank : 39)
Query Neighborhood Hits	74	Target Neighborhood Hits	193	Shared Neighborhood Hits	10
SwissProt Accessions	Q13117, Q96P41, Q9NR91	Gene names	DAZ2
Domain Architecture
Description	Deleted in azoospermia protein 2.

DAZ4_HUMAN
NC score	0.041041 (rank : 23)	θ value	2.36792 (rank : 41)
Query Neighborhood Hits	74	Target Neighborhood Hits	192	Shared Neighborhood Hits	10
SwissProt Accessions	Q86SG3, Q9NR88, Q9NR89	Gene names	DAZ4
Domain Architecture
Description	Deleted in azoospermia protein 4.

DAZ1_HUMAN
NC score	0.040880 (rank : 24)	θ value	2.36792 (rank : 38)
Query Neighborhood Hits	74	Target Neighborhood Hits	192	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NQZ3, Q9NQZ4	Gene names	DAZ1, DAZ
Domain Architecture
Description	Deleted in azoospermia protein 1.

MISS_MOUSE
NC score	0.035228 (rank : 25)	θ value	6.88961 (rank : 66)
Query Neighborhood Hits	74	Target Neighborhood Hits	444	Shared Neighborhood Hits	22
SwissProt Accessions	Q9D7G9, Q7M749	Gene names	Mapk1ip1, Miss
Domain Architecture	No domain graphic available
Description	MAPK-interacting and spindle-stabilizing protein (Mitogen-activated protein kinase 1-interacting protein 1).

ARI1B_HUMAN
NC score	0.028250 (rank : 26)	θ value	0.813845 (rank : 30)
Query Neighborhood Hits	74	Target Neighborhood Hits	567	Shared Neighborhood Hits	23
SwissProt Accessions	Q8NFD5, Q5JRD1, Q5VYC4, Q8IZY8, Q8TEV0, Q8TF02, Q99491, Q9ULI5	Gene names	ARID1B, DAN15, KIAA1235, OSA2
Domain Architecture	No domain graphic available
Description	AT-rich interactive domain-containing protein 1B (ARID domain- containing protein 1B) (Osa homolog 2) (hOsa2) (p250R) (BRG1-binding protein hELD/OSA1) (BRG1-associated factor 250b) (BAF250B).

MLL3_MOUSE
NC score	0.027994 (rank : 27)	θ value	0.125558 (rank : 19)
Query Neighborhood Hits	74	Target Neighborhood Hits	1399	Shared Neighborhood Hits	31
SwissProt Accessions	Q8BRH4, Q5YLV9, Q8BK12, Q8C6M3, Q923H5, Q923H6	Gene names	Mll3
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3).

K0256_HUMAN
NC score	0.023888 (rank : 28)	θ value	3.0926 (rank : 44)
Query Neighborhood Hits	74	Target Neighborhood Hits	73	Shared Neighborhood Hits	5
SwissProt Accessions	Q93073, Q8N767	Gene names	KIAA0256
Domain Architecture	No domain graphic available
Description	Protein KIAA0256.

ZIM10_HUMAN
NC score	0.023858 (rank : 29)	θ value	5.27518 (rank : 60)
Query Neighborhood Hits	74	Target Neighborhood Hits	577	Shared Neighborhood Hits	25
SwissProt Accessions	Q9ULJ6, Q7Z7E6	Gene names	RAI17, KIAA1224, ZIMP10
Domain Architecture	No domain graphic available
Description	Retinoic acid-induced protein 17 (PIAS-like protein Zimp10).

MLL3_HUMAN
NC score	0.023381 (rank : 30)	θ value	1.06291 (rank : 33)
Query Neighborhood Hits	74	Target Neighborhood Hits	1644	Shared Neighborhood Hits	28
SwissProt Accessions	Q8NEZ4, Q8NC02, Q8NDF6, Q9H9P4, Q9NR13, Q9P222, Q9UDR7	Gene names	MLL3, HALR, KIAA1506
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog (EC 2.1.1.43) (Histone-lysine N-methyltransferase, H3 lysine-4 specific MLL3) (Homologous to ALR protein).

K0256_MOUSE
NC score	0.023318 (rank : 31)	θ value	3.0926 (rank : 45)
Query Neighborhood Hits	74	Target Neighborhood Hits	121	Shared Neighborhood Hits	5
SwissProt Accessions	Q6A098	Gene names	Kiaa0256
Domain Architecture	No domain graphic available
Description	Protein KIAA0256.

CSKI1_MOUSE
NC score	0.023015 (rank : 32)	θ value	0.163984 (rank : 20)
Query Neighborhood Hits	74	Target Neighborhood Hits	1031	Shared Neighborhood Hits	24
SwissProt Accessions	Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0	Gene names	Caskin1, Kiaa1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

LPP_HUMAN
NC score	0.022400 (rank : 33)	θ value	0.47712 (rank : 26)
Query Neighborhood Hits	74	Target Neighborhood Hits	775	Shared Neighborhood Hits	23
SwissProt Accessions	Q93052, Q8NFX5	Gene names	LPP
Domain Architecture	No domain graphic available
Description	Lipoma-preferred partner (LIM domain-containing preferred translocation partner in lipoma).

KBTB4_HUMAN
NC score	0.022332 (rank : 34)	θ value	0.47712 (rank : 25)
Query Neighborhood Hits	74	Target Neighborhood Hits	187	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NVX7, Q6IA85, Q9BUC3, Q9NV76	Gene names	KBTBD4, BKLHD4
Domain Architecture
Description	Kelch repeat and BTB domain-containing protein 4 (BTB and kelch domain-containing protein 4).

NPBL_MOUSE
NC score	0.020829 (rank : 35)	θ value	0.47712 (rank : 28)
Query Neighborhood Hits	74	Target Neighborhood Hits	1041	Shared Neighborhood Hits	14
SwissProt Accessions	Q6KCD5, Q6KC78, Q7TNS4, Q8BKV4, Q8CES9, Q9CUC6	Gene names	Nipbl
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin homolog) (SCC2 homolog).

IRF7_HUMAN
NC score	0.019669 (rank : 36)	θ value	5.27518 (rank : 59)
Query Neighborhood Hits	74	Target Neighborhood Hits	73	Shared Neighborhood Hits	8
SwissProt Accessions	Q92985, O00331, O00332, O00333, O75924	Gene names	IRF7
Domain Architecture
Description	Interferon regulatory factor 7 (IRF-7).

FOXJ1_MOUSE
NC score	0.019223 (rank : 37)	θ value	0.163984 (rank : 21)
Query Neighborhood Hits	74	Target Neighborhood Hits	209	Shared Neighborhood Hits	5
SwissProt Accessions	Q61660	Gene names	Foxj1, Fkhl13, Hfh4
Domain Architecture
Description	Forkhead box protein J1 (Forkhead-related protein FKHL13) (Hepatocyte nuclear factor 3 forkhead homolog 4) (HFH-4).

TSKS_MOUSE
NC score	0.018348 (rank : 38)	θ value	3.0926 (rank : 47)
Query Neighborhood Hits	74	Target Neighborhood Hits	188	Shared Neighborhood Hits	6
SwissProt Accessions	O54887	Gene names	Stk22s1, Tsks
Domain Architecture	No domain graphic available
Description	Testis-specific serine kinase substrate (Testis-specific kinase substrate) (STK22 substrate 1).

K1543_MOUSE
NC score	0.017987 (rank : 39)	θ value	3.0926 (rank : 46)
Query Neighborhood Hits	74	Target Neighborhood Hits	497	Shared Neighborhood Hits	21
SwissProt Accessions	Q80VC9, Q5DTW9, Q8BUZ0	Gene names	Kiaa1543
Domain Architecture	No domain graphic available
Description	Protein KIAA1543.

NIPBL_HUMAN
NC score	0.017927 (rank : 40)	θ value	0.47712 (rank : 27)
Query Neighborhood Hits	74	Target Neighborhood Hits	1311	Shared Neighborhood Hits	16
SwissProt Accessions	Q6KC79, Q6KCD6, Q6N080, Q6ZT92, Q7Z2E6, Q8N4M5, Q9Y6Y3, Q9Y6Y4	Gene names	NIPBL, IDN3
Domain Architecture	No domain graphic available
Description	Nipped-B-like protein (Delangin) (SCC2 homolog).

HRX_HUMAN
NC score	0.017011 (rank : 41)	θ value	5.27518 (rank : 57)
Query Neighborhood Hits	74	Target Neighborhood Hits	825	Shared Neighborhood Hits	20
SwissProt Accessions	Q03164, Q13743, Q13744, Q14845, Q16364, Q6UBD1, Q9UMA3	Gene names	MLL, ALL1, HRX, HTRX, TRX1
Domain Architecture
Description	Zinc finger protein HRX (ALL-1) (Trithorax-like protein).

TSKS_HUMAN
NC score	0.016632 (rank : 42)	θ value	4.03905 (rank : 54)
Query Neighborhood Hits	74	Target Neighborhood Hits	220	Shared Neighborhood Hits	5
SwissProt Accessions	Q9UJT2, Q8WXJ0	Gene names	STK22S1, TSKS, TSKS1
Domain Architecture	No domain graphic available
Description	Testis-specific serine kinase substrate (Testis-specific kinase substrate) (STK22 substrate 1).

TENS4_HUMAN
NC score	0.016453 (rank : 43)	θ value	4.03905 (rank : 53)
Query Neighborhood Hits	74	Target Neighborhood Hits	214	Shared Neighborhood Hits	5
SwissProt Accessions	Q8IZW8, Q71RB7, Q8WV64, Q96JV4	Gene names	TNS4, CTEN
Domain Architecture	No domain graphic available
Description	Tensin-4 precursor (C-terminal tensin-like protein).

EVX1_MOUSE
NC score	0.016341 (rank : 44)	θ value	0.365318 (rank : 23)
Query Neighborhood Hits	74	Target Neighborhood Hits	350	Shared Neighborhood Hits	8
SwissProt Accessions	P23683	Gene names	Evx1
Domain Architecture
Description	Homeobox even-skipped homolog protein 1 (EVX-1).

EVX1_HUMAN
NC score	0.016247 (rank : 45)	θ value	0.365318 (rank : 22)
Query Neighborhood Hits	74	Target Neighborhood Hits	349	Shared Neighborhood Hits	6
SwissProt Accessions	P49640	Gene names	EVX1
Domain Architecture
Description	Homeobox even-skipped homolog protein 1 (EVX-1).

CD248_MOUSE
NC score	0.014753 (rank : 46)	θ value	8.99809 (rank : 68)
Query Neighborhood Hits	74	Target Neighborhood Hits	578	Shared Neighborhood Hits	15
SwissProt Accessions	Q91V98, Q3UMV6, Q91ZV1	Gene names	Cd248, Tem1
Domain Architecture	No domain graphic available
Description	Endosialin precursor (Tumor endothelial marker 1) (CD248 antigen).

BCAR1_HUMAN
NC score	0.014016 (rank : 47)	θ value	1.38821 (rank : 34)
Query Neighborhood Hits	74	Target Neighborhood Hits	554	Shared Neighborhood Hits	22
SwissProt Accessions	P56945	Gene names	BCAR1, CAS, CRKAS
Domain Architecture
Description	Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas).

SUSD4_MOUSE
NC score	0.013869 (rank : 48)	θ value	1.38821 (rank : 36)
Query Neighborhood Hits	74	Target Neighborhood Hits	122	Shared Neighborhood Hits	3
SwissProt Accessions	Q8BH32, Q8VC43	Gene names	Susd4
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 4 precursor.

BOP1_MOUSE
NC score	0.013287 (rank : 49)	θ value	1.81305 (rank : 37)
Query Neighborhood Hits	74	Target Neighborhood Hits	267	Shared Neighborhood Hits	4
SwissProt Accessions	P97452, Q3TK87, Q91X31	Gene names	Bop1
Domain Architecture
Description	Ribosome biogenesis protein BOP1 (Block of proliferation 1 protein).

HELZ_HUMAN
NC score	0.013250 (rank : 50)	θ value	6.88961 (rank : 64)
Query Neighborhood Hits	74	Target Neighborhood Hits	198	Shared Neighborhood Hits	13
SwissProt Accessions	P42694	Gene names	HELZ, KIAA0054
Domain Architecture	No domain graphic available
Description	Probable helicase with zinc-finger domain (EC 3.6.1.-).

CSKI1_HUMAN
NC score	0.013198 (rank : 51)	θ value	8.99809 (rank : 69)
Query Neighborhood Hits	74	Target Neighborhood Hits	997	Shared Neighborhood Hits	24
SwissProt Accessions	Q8WXD9, Q9P2P0	Gene names	CASKIN1, KIAA1306
Domain Architecture	No domain graphic available
Description	Caskin-1 (CASK-interacting protein 1).

NACAM_MOUSE
NC score	0.012911 (rank : 52)	θ value	4.03905 (rank : 48)
Query Neighborhood Hits	74	Target Neighborhood Hits	1866	Shared Neighborhood Hits	32
SwissProt Accessions	P70670	Gene names	Naca
Domain Architecture	No domain graphic available
Description	Nascent polypeptide-associated complex subunit alpha, muscle-specific form (Alpha-NAC, muscle-specific form).

ZIMP7_MOUSE
NC score	0.012891 (rank : 53)	θ value	4.03905 (rank : 55)
Query Neighborhood Hits	74	Target Neighborhood Hits	566	Shared Neighborhood Hits	21
SwissProt Accessions	Q8CIE2, Q6P558, Q6P9Q5, Q8BJ00	Gene names	Zimp7, D11Bwg0280e
Domain Architecture	No domain graphic available
Description	PIAS-like protein Zimp7.

NUFP1_HUMAN
NC score	0.012787 (rank : 54)	θ value	4.03905 (rank : 50)
Query Neighborhood Hits	74	Target Neighborhood Hits	193	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UHK0, Q8WVM5, Q96SG1	Gene names	NUFIP1
Domain Architecture	No domain graphic available
Description	Nuclear fragile X mental retardation-interacting protein 1 (Nuclear FMRP-interacting protein 1).

KBTB4_MOUSE
NC score	0.012721 (rank : 55)	θ value	2.36792 (rank : 42)
Query Neighborhood Hits	74	Target Neighborhood Hits	182	Shared Neighborhood Hits	4
SwissProt Accessions	Q8R179, Q9CQX1	Gene names	Kbtbd4, Bklhd4
Domain Architecture
Description	Kelch repeat and BTB domain-containing protein 4 (BTB and kelch domain-containing protein 4).

PSL1_HUMAN
NC score	0.012520 (rank : 56)	θ value	4.03905 (rank : 51)
Query Neighborhood Hits	74	Target Neighborhood Hits	650	Shared Neighborhood Hits	17
SwissProt Accessions	Q8TCT7, O60365, Q567S3, Q8IUH9, Q9BUY6, Q9H3M4, Q9NPN2, Q9P1Z6	Gene names	SPPL2B, KIAA1532, PSL1
Domain Architecture
Description	Signal peptide peptidase-like 2B (EC 3.4.23.-) (Protein SPP-like 2B) (Protein SPPL2b) (Intramembrane protease 4) (IMP4) (Presenilin-like protein 1).

IL3RB_MOUSE
NC score	0.011077 (rank : 57)	θ value	8.99809 (rank : 73)
Query Neighborhood Hits	74	Target Neighborhood Hits	355	Shared Neighborhood Hits	10
SwissProt Accessions	P26955	Gene names	Csf2rb, Aic2b, Csf2rb1, Il3rb1
Domain Architecture
Description	Cytokine receptor common beta chain precursor (GM-CSF/IL-3/IL-5 receptor common beta-chain) (CD131 antigen).

SUSD4_HUMAN
NC score	0.011029 (rank : 58)	θ value	6.88961 (rank : 67)
Query Neighborhood Hits	74	Target Neighborhood Hits	88	Shared Neighborhood Hits	3
SwissProt Accessions	Q5VX71, Q6UX62, Q9BSR0, Q9NWG0	Gene names	SUSD4
Domain Architecture	No domain graphic available
Description	Sushi domain-containing protein 4 precursor.

FAT2_HUMAN
NC score	0.010338 (rank : 59)	θ value	0.47712 (rank : 24)
Query Neighborhood Hits	74	Target Neighborhood Hits	507	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NYQ8, O75091, Q9NSR7	Gene names	FAT2, CDHF8, KIAA0811, MEGF1
Domain Architecture
Description	Protocadherin Fat 2 precursor (hFat2) (Multiple epidermal growth factor-like domains 1).

RGS3_HUMAN
NC score	0.010130 (rank : 60)	θ value	2.36792 (rank : 43)
Query Neighborhood Hits	74	Target Neighborhood Hits	1375	Shared Neighborhood Hits	24
SwissProt Accessions	P49796, Q5VXC1, Q5VZ05, Q6ZRM5, Q8IUQ1, Q8NC47, Q8NFN4, Q8NFN5, Q8TD59, Q8TD68, Q8WXA0	Gene names	RGS3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (RGP3).

TCGAP_HUMAN
NC score	0.009330 (rank : 61)	θ value	0.813845 (rank : 32)
Query Neighborhood Hits	74	Target Neighborhood Hits	872	Shared Neighborhood Hits	19
SwissProt Accessions	O14559, O14552, O14560, Q6ZSP6, Q96CP3, Q9NT23	Gene names	SNX26, TCGAP
Domain Architecture
Description	TC10/CDC42 GTPase-activating protein (Sorting nexin-26).

RGS3_MOUSE
NC score	0.008682 (rank : 62)	θ value	4.03905 (rank : 52)
Query Neighborhood Hits	74	Target Neighborhood Hits	1621	Shared Neighborhood Hits	28
SwissProt Accessions	Q9DC04, Q5SRB1, Q5SRB4, Q5SRB8, Q8CEE3, Q8VI25, Q925G9, Q9JL22, Q9JL23, Q9QXA2	Gene names	Rgs3
Domain Architecture
Description	Regulator of G-protein signaling 3 (RGS3) (C2PA).

GNAS1_MOUSE
NC score	0.008232 (rank : 63)	θ value	6.88961 (rank : 63)
Query Neighborhood Hits	74	Target Neighborhood Hits	651	Shared Neighborhood Hits	20
SwissProt Accessions	Q6R0H7, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8	Gene names	Gnas, Gnas1
Domain Architecture	No domain graphic available
Description	Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas).

KCNN3_HUMAN
NC score	0.007230 (rank : 64)	θ value	6.88961 (rank : 65)
Query Neighborhood Hits	74	Target Neighborhood Hits	216	Shared Neighborhood Hits	9
SwissProt Accessions	Q9UGI6, O43517	Gene names	KCNN3, K3
Domain Architecture
Description	Small conductance calcium-activated potassium channel protein 3 (SK3) (SKCa3).

IRAK3_MOUSE
NC score	0.006564 (rank : 65)	θ value	0.813845 (rank : 31)
Query Neighborhood Hits	74	Target Neighborhood Hits	628	Shared Neighborhood Hits	3
SwissProt Accessions	Q8K4B2, Q8C7U8, Q8CE40, Q8K1S8	Gene names	Irak3
Domain Architecture	No domain graphic available
Description	Interleukin-1 receptor-associated kinase 3 (EC 2.7.11.1) (IRAK-3) (IL- 1 receptor-associated kinase M) (IRAK-M).

IL16_MOUSE
NC score	0.005745 (rank : 66)	θ value	5.27518 (rank : 58)
Query Neighborhood Hits	74	Target Neighborhood Hits	189	Shared Neighborhood Hits	3
SwissProt Accessions	O54824, O70236, Q3TEM4, Q8R0G5	Gene names	Il16
Domain Architecture	No domain graphic available
Description	Interleukin-16 precursor (IL-16) (Lymphocyte chemoattractant factor) (LCF).

RB_MOUSE
NC score	0.005407 (rank : 67)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	74	Target Neighborhood Hits	31	Shared Neighborhood Hits	3
SwissProt Accessions	P13405	Gene names	Rb1, Rb-1
Domain Architecture
Description	Retinoblastoma-associated protein (PP105) (RB).

NALP1_HUMAN
NC score	0.005239 (rank : 68)	θ value	4.03905 (rank : 49)
Query Neighborhood Hits	74	Target Neighborhood Hits	138	Shared Neighborhood Hits	6
SwissProt Accessions	Q9C000, Q9BZZ8, Q9BZZ9, Q9HAV8, Q9UFT4, Q9Y2E0	Gene names	NALP1, CARD7, DEFCAP, KIAA0926, NAC
Domain Architecture
Description	NACHT, LRR and PYD-containing protein 1 (Death effector filament- forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) (Caspase recruitment domain protein 7).

ZO1_HUMAN
NC score	0.004708 (rank : 69)	θ value	5.27518 (rank : 61)
Query Neighborhood Hits	74	Target Neighborhood Hits	474	Shared Neighborhood Hits	13
SwissProt Accessions	Q07157, Q4ZGJ6	Gene names	TJP1, ZO1
Domain Architecture
Description	Tight junction protein ZO-1 (Zonula occludens 1 protein) (Zona occludens 1 protein) (Tight junction protein 1).

HXD3_HUMAN
NC score	0.003784 (rank : 70)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	74	Target Neighborhood Hits	433	Shared Neighborhood Hits	12
SwissProt Accessions	P31249, Q99955, Q9BSC5	Gene names	HOXD3, HOX4A
Domain Architecture
Description	Homeobox protein Hox-D3 (Hox-4A).

DLX4_MOUSE
NC score	0.002385 (rank : 71)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	74	Target Neighborhood Hits	352	Shared Neighborhood Hits	6
SwissProt Accessions	P70436, Q3UM51, Q8R4I3	Gene names	Dlx4, Dlx7
Domain Architecture
Description	Homeobox protein DLX-4 (DLX-7).

GP124_MOUSE
NC score	0.002098 (rank : 72)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	74	Target Neighborhood Hits	423	Shared Neighborhood Hits	7
SwissProt Accessions	Q91ZV8	Gene names	Gpr124, Tem5
Domain Architecture
Description	Probable G-protein coupled receptor 124 precursor (Tumor endothelial marker 5).

CDON_MOUSE
NC score	0.001828 (rank : 73)	θ value	6.88961 (rank : 62)
Query Neighborhood Hits	74	Target Neighborhood Hits	410	Shared Neighborhood Hits	3
SwissProt Accessions	Q32MD9, O88971	Gene names	Cdon, Cdo
Domain Architecture	No domain graphic available
Description	Cell adhesion molecule-related/down-regulated by oncogenes precursor.

GOGA1_HUMAN
NC score	-0.000878 (rank : 74)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	74	Target Neighborhood Hits	1222	Shared Neighborhood Hits	6
SwissProt Accessions	Q92805, Q8IYZ9	Gene names	GOLGA1
Domain Architecture
Description	Golgin subfamily A member 1 (Golgin-97).