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Network neighborhood for query Sequence : MCE1_HUMAN

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MCE1_HUMAN
SwissProt Accessions	O60942, O43483, O60257, O60351	Gene names	RNGTT, CAP1A
Domain Architecture
Description	mRNA capping enzyme (HCE) (HCAP1) [Includes: Polynucleotide 5'- triphosphatase (EC 3.1.3.33) (mRNA 5'-triphosphatase) (TPase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)].
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

MCE1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	34	Target Neighborhood Hits	34	Shared Neighborhood Hits	34
SwissProt Accessions	O60942, O43483, O60257, O60351	Gene names	RNGTT, CAP1A
Domain Architecture
Description	mRNA capping enzyme (HCE) (HCAP1) [Includes: Polynucleotide 5'- triphosphatase (EC 3.1.3.33) (mRNA 5'-triphosphatase) (TPase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)].

MCE1_MOUSE
θ value	0 (rank : 2)	NC score	0.998760 (rank : 2)
Query Neighborhood Hits	34	Target Neighborhood Hits	36	Shared Neighborhood Hits	32
SwissProt Accessions	O55236	Gene names	Rngtt, Cap1a
Domain Architecture
Description	mRNA capping enzyme (HCE) (MCE1) [Includes: Polynucleotide 5'- triphosphatase (EC 3.1.3.33) (mRNA 5'-triphosphatase) (TPase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)].

DUS11_MOUSE
θ value	1.42661e-21 (rank : 3)	NC score	0.668941 (rank : 3)
Query Neighborhood Hits	34	Target Neighborhood Hits	41	Shared Neighborhood Hits	19
SwissProt Accessions	Q6NXK5, Q8BTR4, Q8BYE4	Gene names	Dusp11, Pir1
Domain Architecture	No domain graphic available
Description	RNA/RNP complex-1-interacting phosphatase (EC 3.1.3.-) (Phosphatase that interacts with RNA/RNP complex 1) (Dual specificity protein phosphatase 11).

DUS11_HUMAN
θ value	1.5773e-20 (rank : 4)	NC score	0.656453 (rank : 4)
Query Neighborhood Hits	34	Target Neighborhood Hits	37	Shared Neighborhood Hits	18
SwissProt Accessions	O75319, Q6AI47, Q9BWE3	Gene names	DUSP11, PIR1
Domain Architecture
Description	RNA/RNP complex-1-interacting phosphatase (EC 3.1.3.-) (Phosphatase that interacts with RNA/RNP complex 1) (Dual specificity protein phosphatase 11).

DUS23_MOUSE
θ value	8.40245e-06 (rank : 5)	NC score	0.367090 (rank : 5)
Query Neighborhood Hits	34	Target Neighborhood Hits	94	Shared Neighborhood Hits	27
SwissProt Accessions	Q6NT99, Q9CW48	Gene names	Dusp23, Ldp3
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 23 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular mass dual specificity phosphatase 3) (LDP-3).

DUS23_HUMAN
θ value	2.44474e-05 (rank : 6)	NC score	0.362433 (rank : 6)
Query Neighborhood Hits	34	Target Neighborhood Hits	98	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BVJ7, Q9NX48	Gene names	DUSP23, LDP3, VHZ
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 23 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular mass dual specificity phosphatase 3) (LDP-3) (VH1-like phosphatase Z).

PTPM1_MOUSE
θ value	0.00869519 (rank : 7)	NC score	0.249645 (rank : 7)
Query Neighborhood Hits	34	Target Neighborhood Hits	64	Shared Neighborhood Hits	27
SwissProt Accessions	Q66GT5, Q9CSJ8, Q9D622	Gene names	Ptpmt1, Plip
Domain Architecture	No domain graphic available
Description	Protein-tyrosine phosphatase mitochondrial 1, mitochondrial precursor (EC 3.1.3.48) (EC 3.1.3.16) (PTEN-like phosphatase) (Phosphoinositide lipid phosphatase).

PTPM1_HUMAN
θ value	0.0148317 (rank : 8)	NC score	0.229668 (rank : 8)
Query Neighborhood Hits	34	Target Neighborhood Hits	60	Shared Neighborhood Hits	23
SwissProt Accessions	Q8WUK0, Q7Z557, Q96CR2, Q9BXV8	Gene names	PTPMT1, MOSP, PLIP
Domain Architecture	No domain graphic available
Description	Protein-tyrosine phosphatase mitochondrial 1, mitochondrial precursor (EC 3.1.3.48) (EC 3.1.3.16) (PTEN-like phosphatase) (Phosphoinositide lipid phosphatase).

CC14B_HUMAN
θ value	0.0252991 (rank : 9)	NC score	0.206004 (rank : 9)
Query Neighborhood Hits	34	Target Neighborhood Hits	114	Shared Neighborhood Hits	28
SwissProt Accessions	O60729, O43183, O60730	Gene names	CDC14B
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14B (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog B).

CC14A_MOUSE
θ value	0.0736092 (rank : 10)	NC score	0.193577 (rank : 10)
Query Neighborhood Hits	34	Target Neighborhood Hits	117	Shared Neighborhood Hits	28
SwissProt Accessions	Q6GQT0, Q8BZ66	Gene names	Cdc14a
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14A (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog A).

CC14A_HUMAN
θ value	0.0961366 (rank : 11)	NC score	0.192809 (rank : 11)
Query Neighborhood Hits	34	Target Neighborhood Hits	133	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UNH5, O43171, O60727, O60728, Q8IXX0	Gene names	CDC14A
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14A (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog A).

CC14B_MOUSE
θ value	0.0961366 (rank : 12)	NC score	0.191815 (rank : 12)
Query Neighborhood Hits	34	Target Neighborhood Hits	103	Shared Neighborhood Hits	27
SwissProt Accessions	Q6PFY9, Q80WC4, Q8BLV5	Gene names	Cdc14b
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14B (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog B).

TP4A3_MOUSE
θ value	0.0961366 (rank : 13)	NC score	0.172845 (rank : 13)
Query Neighborhood Hits	34	Target Neighborhood Hits	60	Shared Neighborhood Hits	22
SwissProt Accessions	Q9D658, O70275, Q3T9Z5, Q9CTC8	Gene names	Ptp4a3, Prl3
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3).

TPTE_HUMAN
θ value	0.21417 (rank : 14)	NC score	0.127778 (rank : 19)
Query Neighborhood Hits	34	Target Neighborhood Hits	53	Shared Neighborhood Hits	19
SwissProt Accessions	P56180, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8	Gene names	TPTE
Domain Architecture
Description	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Transmembrane phosphatase with tensin homology) (Protein BJ-HCC-5).

TP4A1_HUMAN
θ value	0.279714 (rank : 15)	NC score	0.157822 (rank : 17)
Query Neighborhood Hits	34	Target Neighborhood Hits	68	Shared Neighborhood Hits	20
SwissProt Accessions	Q93096, O00648, Q49A54	Gene names	PTP4A1, PRL1, PTPCAAX1
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1) (PTP(CAAXI)).

TP4A1_MOUSE
θ value	0.279714 (rank : 16)	NC score	0.157822 (rank : 18)
Query Neighborhood Hits	34	Target Neighborhood Hits	68	Shared Neighborhood Hits	20
SwissProt Accessions	Q63739, O09097, O09154, Q3UFU9	Gene names	Ptp4a1, Prl1
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1).

TP4A2_HUMAN
θ value	0.279714 (rank : 17)	NC score	0.158465 (rank : 15)
Query Neighborhood Hits	34	Target Neighborhood Hits	56	Shared Neighborhood Hits	20
SwissProt Accessions	Q12974, O00649, Q15197, Q15259, Q15260, Q15261	Gene names	PTP4A2, PRL2, PTPCAAX2
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2) (PTP(CAAXII)) (HU-PP-1) (OV-1).

TP4A2_MOUSE
θ value	0.279714 (rank : 18)	NC score	0.158465 (rank : 16)
Query Neighborhood Hits	34	Target Neighborhood Hits	56	Shared Neighborhood Hits	20
SwissProt Accessions	O70274, Q3U1K7	Gene names	Ptp4a2, Prl2
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2).

TP4A3_HUMAN
θ value	0.365318 (rank : 19)	NC score	0.167342 (rank : 14)
Query Neighborhood Hits	34	Target Neighborhood Hits	62	Shared Neighborhood Hits	22
SwissProt Accessions	O75365, Q8IVN5, Q99849, Q9BTW5	Gene names	PTP4A3, PRL3
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3) (PRL-R).

ZSWM3_MOUSE
θ value	0.47712 (rank : 20)	NC score	0.058952 (rank : 25)
Query Neighborhood Hits	34	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CFL8	Gene names	Zswim3
Domain Architecture
Description	Zinc finger SWIM domain-containing protein 3.

EPM2A_HUMAN
θ value	1.06291 (rank : 21)	NC score	0.074827 (rank : 23)
Query Neighborhood Hits	34	Target Neighborhood Hits	47	Shared Neighborhood Hits	9
SwissProt Accessions	O95278, O95483, Q8IU96, Q8IX24, Q8IX25, Q9BS66, Q9UEN2	Gene names	EPM2A
Domain Architecture	No domain graphic available
Description	Laforin (EC 3.1.3.48) (EC 3.1.3.16) (Lafora PTPase) (LAFPTPase).

DUS3_MOUSE
θ value	1.38821 (rank : 22)	NC score	0.055720 (rank : 26)
Query Neighborhood Hits	34	Target Neighborhood Hits	54	Shared Neighborhood Hits	16
SwissProt Accessions	Q9D7X3	Gene names	Dusp3
Domain Architecture
Description	Dual specificity protein phosphatase 3 (EC 3.1.3.48) (EC 3.1.3.16) (T- DSP11).

SPN1_MOUSE
θ value	1.81305 (rank : 23)	NC score	0.046918 (rank : 27)
Query Neighborhood Hits	34	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	Q80W37	Gene names	Snupn, Rnut1
Domain Architecture	No domain graphic available
Description	Snurportin-1 (RNA U transporter 1).

TPTE2_HUMAN
θ value	1.81305 (rank : 24)	NC score	0.105268 (rank : 22)
Query Neighborhood Hits	34	Target Neighborhood Hits	68	Shared Neighborhood Hits	20
SwissProt Accessions	Q6XPS3, Q5VUH2, Q8WWL4, Q8WWL5	Gene names	TPTE2, TPIP
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (TPTE and PTEN homologous inositol lipid phosphatase) (Lipid phosphatase TPIP).

DUS16_HUMAN
θ value	2.36792 (rank : 25)	NC score	0.063455 (rank : 24)
Query Neighborhood Hits	34	Target Neighborhood Hits	112	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BY84, Q9C0G3	Gene names	DUSP16, KIAA1700, MKP7
Domain Architecture
Description	Dual specificity protein phosphatase 16 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7).

PTPRJ_HUMAN
θ value	2.36792 (rank : 26)	NC score	0.029098 (rank : 31)
Query Neighborhood Hits	34	Target Neighborhood Hits	207	Shared Neighborhood Hits	19
SwissProt Accessions	Q12913, Q15255, Q8NHM2	Gene names	PTPRJ, DEP1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta) (Protein- tyrosine phosphatase receptor type J) (Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen).

PTEN_HUMAN
θ value	3.0926 (rank : 27)	NC score	0.109690 (rank : 21)
Query Neighborhood Hits	34	Target Neighborhood Hits	72	Shared Neighborhood Hits	25
SwissProt Accessions	P60484, O00633, O02679, Q6ICT7	Gene names	PTEN, MMAC1, TEP1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual- specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16) (EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multiple advanced cancers 1).

PTEN_MOUSE
θ value	3.0926 (rank : 28)	NC score	0.109690 (rank : 20)
Query Neighborhood Hits	34	Target Neighborhood Hits	73	Shared Neighborhood Hits	25
SwissProt Accessions	O08586, Q542G1	Gene names	Pten, Mmac1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN (EC 3.1.3.67) (Mutated in multiple advanced cancers 1).

SPN1_HUMAN
θ value	4.03905 (rank : 29)	NC score	0.041743 (rank : 28)
Query Neighborhood Hits	34	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	O95149	Gene names	SNUPN, RNUT1, SPN1
Domain Architecture	No domain graphic available
Description	Snurportin-1 (RNA U transporter 1).

DUS3_HUMAN
θ value	6.88961 (rank : 30)	NC score	0.041255 (rank : 29)
Query Neighborhood Hits	34	Target Neighborhood Hits	58	Shared Neighborhood Hits	15
SwissProt Accessions	P51452	Gene names	DUSP3, VHR
Domain Architecture
Description	Dual specificity protein phosphatase 3 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase VHR).

FBX34_MOUSE
θ value	6.88961 (rank : 31)	NC score	0.023946 (rank : 32)
Query Neighborhood Hits	34	Target Neighborhood Hits	100	Shared Neighborhood Hits	3
SwissProt Accessions	Q80XI1, Q9D290	Gene names	Fbxo34
Domain Architecture	No domain graphic available
Description	F-box only protein 34.

PTPRJ_MOUSE
θ value	6.88961 (rank : 32)	NC score	0.022447 (rank : 33)
Query Neighborhood Hits	34	Target Neighborhood Hits	188	Shared Neighborhood Hits	18
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

SSH3_MOUSE
θ value	6.88961 (rank : 33)	NC score	0.037413 (rank : 30)
Query Neighborhood Hits	34	Target Neighborhood Hits	69	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K330, Q3UDX0	Gene names	Ssh3, Ssh3l
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 3 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-3L) (mSSH-3L).

GAK_MOUSE
θ value	8.99809 (rank : 34)	NC score	0.008559 (rank : 34)
Query Neighborhood Hits	34	Target Neighborhood Hits	964	Shared Neighborhood Hits	7
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).

Hits sorted by NC score

MCE1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	34	Target Neighborhood Hits	34	Shared Neighborhood Hits	34
SwissProt Accessions	O60942, O43483, O60257, O60351	Gene names	RNGTT, CAP1A
Domain Architecture
Description	mRNA capping enzyme (HCE) (HCAP1) [Includes: Polynucleotide 5'- triphosphatase (EC 3.1.3.33) (mRNA 5'-triphosphatase) (TPase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)].

MCE1_MOUSE
NC score	0.998760 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	34	Target Neighborhood Hits	36	Shared Neighborhood Hits	32
SwissProt Accessions	O55236	Gene names	Rngtt, Cap1a
Domain Architecture
Description	mRNA capping enzyme (HCE) (MCE1) [Includes: Polynucleotide 5'- triphosphatase (EC 3.1.3.33) (mRNA 5'-triphosphatase) (TPase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)].

DUS11_MOUSE
NC score	0.668941 (rank : 3)	θ value	1.42661e-21 (rank : 3)
Query Neighborhood Hits	34	Target Neighborhood Hits	41	Shared Neighborhood Hits	19
SwissProt Accessions	Q6NXK5, Q8BTR4, Q8BYE4	Gene names	Dusp11, Pir1
Domain Architecture	No domain graphic available
Description	RNA/RNP complex-1-interacting phosphatase (EC 3.1.3.-) (Phosphatase that interacts with RNA/RNP complex 1) (Dual specificity protein phosphatase 11).

DUS11_HUMAN
NC score	0.656453 (rank : 4)	θ value	1.5773e-20 (rank : 4)
Query Neighborhood Hits	34	Target Neighborhood Hits	37	Shared Neighborhood Hits	18
SwissProt Accessions	O75319, Q6AI47, Q9BWE3	Gene names	DUSP11, PIR1
Domain Architecture
Description	RNA/RNP complex-1-interacting phosphatase (EC 3.1.3.-) (Phosphatase that interacts with RNA/RNP complex 1) (Dual specificity protein phosphatase 11).

DUS23_MOUSE
NC score	0.367090 (rank : 5)	θ value	8.40245e-06 (rank : 5)
Query Neighborhood Hits	34	Target Neighborhood Hits	94	Shared Neighborhood Hits	27
SwissProt Accessions	Q6NT99, Q9CW48	Gene names	Dusp23, Ldp3
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 23 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular mass dual specificity phosphatase 3) (LDP-3).

DUS23_HUMAN
NC score	0.362433 (rank : 6)	θ value	2.44474e-05 (rank : 6)
Query Neighborhood Hits	34	Target Neighborhood Hits	98	Shared Neighborhood Hits	28
SwissProt Accessions	Q9BVJ7, Q9NX48	Gene names	DUSP23, LDP3, VHZ
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase 23 (EC 3.1.3.48) (EC 3.1.3.16) (Low molecular mass dual specificity phosphatase 3) (LDP-3) (VH1-like phosphatase Z).

PTPM1_MOUSE
NC score	0.249645 (rank : 7)	θ value	0.00869519 (rank : 7)
Query Neighborhood Hits	34	Target Neighborhood Hits	64	Shared Neighborhood Hits	27
SwissProt Accessions	Q66GT5, Q9CSJ8, Q9D622	Gene names	Ptpmt1, Plip
Domain Architecture	No domain graphic available
Description	Protein-tyrosine phosphatase mitochondrial 1, mitochondrial precursor (EC 3.1.3.48) (EC 3.1.3.16) (PTEN-like phosphatase) (Phosphoinositide lipid phosphatase).

PTPM1_HUMAN
NC score	0.229668 (rank : 8)	θ value	0.0148317 (rank : 8)
Query Neighborhood Hits	34	Target Neighborhood Hits	60	Shared Neighborhood Hits	23
SwissProt Accessions	Q8WUK0, Q7Z557, Q96CR2, Q9BXV8	Gene names	PTPMT1, MOSP, PLIP
Domain Architecture	No domain graphic available
Description	Protein-tyrosine phosphatase mitochondrial 1, mitochondrial precursor (EC 3.1.3.48) (EC 3.1.3.16) (PTEN-like phosphatase) (Phosphoinositide lipid phosphatase).

CC14B_HUMAN
NC score	0.206004 (rank : 9)	θ value	0.0252991 (rank : 9)
Query Neighborhood Hits	34	Target Neighborhood Hits	114	Shared Neighborhood Hits	28
SwissProt Accessions	O60729, O43183, O60730	Gene names	CDC14B
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14B (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog B).

CC14A_MOUSE
NC score	0.193577 (rank : 10)	θ value	0.0736092 (rank : 10)
Query Neighborhood Hits	34	Target Neighborhood Hits	117	Shared Neighborhood Hits	28
SwissProt Accessions	Q6GQT0, Q8BZ66	Gene names	Cdc14a
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14A (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog A).

CC14A_HUMAN
NC score	0.192809 (rank : 11)	θ value	0.0961366 (rank : 11)
Query Neighborhood Hits	34	Target Neighborhood Hits	133	Shared Neighborhood Hits	28
SwissProt Accessions	Q9UNH5, O43171, O60727, O60728, Q8IXX0	Gene names	CDC14A
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14A (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog A).

CC14B_MOUSE
NC score	0.191815 (rank : 12)	θ value	0.0961366 (rank : 12)
Query Neighborhood Hits	34	Target Neighborhood Hits	103	Shared Neighborhood Hits	27
SwissProt Accessions	Q6PFY9, Q80WC4, Q8BLV5	Gene names	Cdc14b
Domain Architecture	No domain graphic available
Description	Dual specificity protein phosphatase CDC14B (EC 3.1.3.48) (EC 3.1.3.16) (CDC14 cell division cycle 14 homolog B).

TP4A3_MOUSE
NC score	0.172845 (rank : 13)	θ value	0.0961366 (rank : 13)
Query Neighborhood Hits	34	Target Neighborhood Hits	60	Shared Neighborhood Hits	22
SwissProt Accessions	Q9D658, O70275, Q3T9Z5, Q9CTC8	Gene names	Ptp4a3, Prl3
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3).

TP4A3_HUMAN
NC score	0.167342 (rank : 14)	θ value	0.365318 (rank : 19)
Query Neighborhood Hits	34	Target Neighborhood Hits	62	Shared Neighborhood Hits	22
SwissProt Accessions	O75365, Q8IVN5, Q99849, Q9BTW5	Gene names	PTP4A3, PRL3
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a3) (Protein-tyrosine phosphatase of regenerating liver 3) (PRL-3) (PRL-R).

TP4A2_HUMAN
NC score	0.158465 (rank : 15)	θ value	0.279714 (rank : 17)
Query Neighborhood Hits	34	Target Neighborhood Hits	56	Shared Neighborhood Hits	20
SwissProt Accessions	Q12974, O00649, Q15197, Q15259, Q15260, Q15261	Gene names	PTP4A2, PRL2, PTPCAAX2
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2) (PTP(CAAXII)) (HU-PP-1) (OV-1).

TP4A2_MOUSE
NC score	0.158465 (rank : 16)	θ value	0.279714 (rank : 18)
Query Neighborhood Hits	34	Target Neighborhood Hits	56	Shared Neighborhood Hits	20
SwissProt Accessions	O70274, Q3U1K7	Gene names	Ptp4a2, Prl2
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 2 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a2) (Protein-tyrosine phosphatase of regenerating liver 2) (PRL-2).

TP4A1_HUMAN
NC score	0.157822 (rank : 17)	θ value	0.279714 (rank : 15)
Query Neighborhood Hits	34	Target Neighborhood Hits	68	Shared Neighborhood Hits	20
SwissProt Accessions	Q93096, O00648, Q49A54	Gene names	PTP4A1, PRL1, PTPCAAX1
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1) (PTP(CAAXI)).

TP4A1_MOUSE
NC score	0.157822 (rank : 18)	θ value	0.279714 (rank : 16)
Query Neighborhood Hits	34	Target Neighborhood Hits	68	Shared Neighborhood Hits	20
SwissProt Accessions	Q63739, O09097, O09154, Q3UFU9	Gene names	Ptp4a1, Prl1
Domain Architecture	No domain graphic available
Description	Protein tyrosine phosphatase type IVA protein 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 4a1) (Protein-tyrosine phosphatase of regenerating liver 1) (PRL-1).

TPTE_HUMAN
NC score	0.127778 (rank : 19)	θ value	0.21417 (rank : 14)
Query Neighborhood Hits	34	Target Neighborhood Hits	53	Shared Neighborhood Hits	19
SwissProt Accessions	P56180, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8	Gene names	TPTE
Domain Architecture
Description	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Transmembrane phosphatase with tensin homology) (Protein BJ-HCC-5).

PTEN_MOUSE
NC score	0.109690 (rank : 20)	θ value	3.0926 (rank : 28)
Query Neighborhood Hits	34	Target Neighborhood Hits	73	Shared Neighborhood Hits	25
SwissProt Accessions	O08586, Q542G1	Gene names	Pten, Mmac1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase PTEN (EC 3.1.3.67) (Mutated in multiple advanced cancers 1).

PTEN_HUMAN
NC score	0.109690 (rank : 21)	θ value	3.0926 (rank : 27)
Query Neighborhood Hits	34	Target Neighborhood Hits	72	Shared Neighborhood Hits	25
SwissProt Accessions	P60484, O00633, O02679, Q6ICT7	Gene names	PTEN, MMAC1, TEP1
Domain Architecture
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual- specificity protein phosphatase PTEN (EC 3.1.3.67) (EC 3.1.3.16) (EC 3.1.3.48) (Phosphatase and tensin homolog) (Mutated in multiple advanced cancers 1).

TPTE2_HUMAN
NC score	0.105268 (rank : 22)	θ value	1.81305 (rank : 24)
Query Neighborhood Hits	34	Target Neighborhood Hits	68	Shared Neighborhood Hits	20
SwissProt Accessions	Q6XPS3, Q5VUH2, Q8WWL4, Q8WWL5	Gene names	TPTE2, TPIP
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (TPTE and PTEN homologous inositol lipid phosphatase) (Lipid phosphatase TPIP).

EPM2A_HUMAN
NC score	0.074827 (rank : 23)	θ value	1.06291 (rank : 21)
Query Neighborhood Hits	34	Target Neighborhood Hits	47	Shared Neighborhood Hits	9
SwissProt Accessions	O95278, O95483, Q8IU96, Q8IX24, Q8IX25, Q9BS66, Q9UEN2	Gene names	EPM2A
Domain Architecture	No domain graphic available
Description	Laforin (EC 3.1.3.48) (EC 3.1.3.16) (Lafora PTPase) (LAFPTPase).

DUS16_HUMAN
NC score	0.063455 (rank : 24)	θ value	2.36792 (rank : 25)
Query Neighborhood Hits	34	Target Neighborhood Hits	112	Shared Neighborhood Hits	25
SwissProt Accessions	Q9BY84, Q9C0G3	Gene names	DUSP16, KIAA1700, MKP7
Domain Architecture
Description	Dual specificity protein phosphatase 16 (EC 3.1.3.48) (EC 3.1.3.16) (Mitogen-activated protein kinase phosphatase 7) (MAP kinase phosphatase 7) (MKP-7).

ZSWM3_MOUSE
NC score	0.058952 (rank : 25)	θ value	0.47712 (rank : 20)
Query Neighborhood Hits	34	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q8CFL8	Gene names	Zswim3
Domain Architecture
Description	Zinc finger SWIM domain-containing protein 3.

DUS3_MOUSE
NC score	0.055720 (rank : 26)	θ value	1.38821 (rank : 22)
Query Neighborhood Hits	34	Target Neighborhood Hits	54	Shared Neighborhood Hits	16
SwissProt Accessions	Q9D7X3	Gene names	Dusp3
Domain Architecture
Description	Dual specificity protein phosphatase 3 (EC 3.1.3.48) (EC 3.1.3.16) (T- DSP11).

SPN1_MOUSE
NC score	0.046918 (rank : 27)	θ value	1.81305 (rank : 23)
Query Neighborhood Hits	34	Target Neighborhood Hits	12	Shared Neighborhood Hits	3
SwissProt Accessions	Q80W37	Gene names	Snupn, Rnut1
Domain Architecture	No domain graphic available
Description	Snurportin-1 (RNA U transporter 1).

SPN1_HUMAN
NC score	0.041743 (rank : 28)	θ value	4.03905 (rank : 29)
Query Neighborhood Hits	34	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	O95149	Gene names	SNUPN, RNUT1, SPN1
Domain Architecture	No domain graphic available
Description	Snurportin-1 (RNA U transporter 1).

DUS3_HUMAN
NC score	0.041255 (rank : 29)	θ value	6.88961 (rank : 30)
Query Neighborhood Hits	34	Target Neighborhood Hits	58	Shared Neighborhood Hits	15
SwissProt Accessions	P51452	Gene names	DUSP3, VHR
Domain Architecture
Description	Dual specificity protein phosphatase 3 (EC 3.1.3.48) (EC 3.1.3.16) (Dual specificity protein phosphatase VHR).

SSH3_MOUSE
NC score	0.037413 (rank : 30)	θ value	6.88961 (rank : 33)
Query Neighborhood Hits	34	Target Neighborhood Hits	69	Shared Neighborhood Hits	15
SwissProt Accessions	Q8K330, Q3UDX0	Gene names	Ssh3, Ssh3l
Domain Architecture	No domain graphic available
Description	Protein phosphatase Slingshot homolog 3 (EC 3.1.3.48) (EC 3.1.3.16) (SSH-3L) (mSSH-3L).

PTPRJ_HUMAN
NC score	0.029098 (rank : 31)	θ value	2.36792 (rank : 26)
Query Neighborhood Hits	34	Target Neighborhood Hits	207	Shared Neighborhood Hits	19
SwissProt Accessions	Q12913, Q15255, Q8NHM2	Gene names	PTPRJ, DEP1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP eta) (Protein- tyrosine phosphatase receptor type J) (Density-enhanced phosphatase 1) (DEP-1) (CD148 antigen).

FBX34_MOUSE
NC score	0.023946 (rank : 32)	θ value	6.88961 (rank : 31)
Query Neighborhood Hits	34	Target Neighborhood Hits	100	Shared Neighborhood Hits	3
SwissProt Accessions	Q80XI1, Q9D290	Gene names	Fbxo34
Domain Architecture	No domain graphic available
Description	F-box only protein 34.

PTPRJ_MOUSE
NC score	0.022447 (rank : 33)	θ value	6.88961 (rank : 32)
Query Neighborhood Hits	34	Target Neighborhood Hits	188	Shared Neighborhood Hits	18
SwissProt Accessions	Q64455	Gene names	Ptprj, Byp, Scc1
Domain Architecture
Description	Receptor-type tyrosine-protein phosphatase eta precursor (EC 3.1.3.48) (Protein-tyrosine phosphatase eta) (R-PTP-eta) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (Susceptibility to colon cancer 1).

GAK_MOUSE
NC score	0.008559 (rank : 34)	θ value	8.99809 (rank : 34)
Query Neighborhood Hits	34	Target Neighborhood Hits	964	Shared Neighborhood Hits	7
SwissProt Accessions	Q99KY4, Q6P1I8, Q6P9S5, Q8BM74, Q8K0Q4	Gene names	Gak
Domain Architecture	No domain graphic available
Description	Cyclin G-associated kinase (EC 2.7.11.1).