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Network neighborhood for query Sequence : CAC1D_HUMAN

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CAC1D_HUMAN
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

CAC1A_HUMAN
θ value	0 (rank : 1)	NC score	0.946986 (rank : 13)
Query Neighborhood Hits	118	Target Neighborhood Hits	387	Shared Neighborhood Hits	63
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1A_MOUSE
θ value	0 (rank : 2)	NC score	0.955621 (rank : 11)
Query Neighborhood Hits	118	Target Neighborhood Hits	267	Shared Neighborhood Hits	64
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1B_HUMAN
θ value	0 (rank : 3)	NC score	0.955878 (rank : 10)
Query Neighborhood Hits	118	Target Neighborhood Hits	257	Shared Neighborhood Hits	59
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1B_MOUSE
θ value	0 (rank : 4)	NC score	0.951249 (rank : 12)
Query Neighborhood Hits	118	Target Neighborhood Hits	351	Shared Neighborhood Hits	63
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1C_HUMAN
θ value	0 (rank : 5)	NC score	0.993159 (rank : 7)
Query Neighborhood Hits	118	Target Neighborhood Hits	158	Shared Neighborhood Hits	59
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

CAC1C_MOUSE
θ value	0 (rank : 6)	NC score	0.994293 (rank : 4)
Query Neighborhood Hits	118	Target Neighborhood Hits	130	Shared Neighborhood Hits	60
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

CAC1D_HUMAN
θ value	0 (rank : 7)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	118	Target Neighborhood Hits	118	Shared Neighborhood Hits	118
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

CAC1E_HUMAN
θ value	0 (rank : 8)	NC score	0.959340 (rank : 9)
Query Neighborhood Hits	118	Target Neighborhood Hits	148	Shared Neighborhood Hits	58
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1E_MOUSE
θ value	0 (rank : 9)	NC score	0.959422 (rank : 8)
Query Neighborhood Hits	118	Target Neighborhood Hits	167	Shared Neighborhood Hits	58
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1F_HUMAN
θ value	0 (rank : 10)	NC score	0.993397 (rank : 6)
Query Neighborhood Hits	118	Target Neighborhood Hits	141	Shared Neighborhood Hits	63
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1F_MOUSE
θ value	0 (rank : 11)	NC score	0.993541 (rank : 5)
Query Neighborhood Hits	118	Target Neighborhood Hits	142	Shared Neighborhood Hits	64
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1S_HUMAN
θ value	0 (rank : 12)	NC score	0.995599 (rank : 2)
Query Neighborhood Hits	118	Target Neighborhood Hits	92	Shared Neighborhood Hits	60
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1S_MOUSE
θ value	0 (rank : 13)	NC score	0.994651 (rank : 3)
Query Neighborhood Hits	118	Target Neighborhood Hits	98	Shared Neighborhood Hits	62
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

SC11A_MOUSE
θ value	7.93343e-89 (rank : 14)	NC score	0.866604 (rank : 17)
Query Neighborhood Hits	118	Target Neighborhood Hits	116	Shared Neighborhood Hits	65
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

SCN3A_HUMAN
θ value	3.23591e-74 (rank : 15)	NC score	0.849178 (rank : 23)
Query Neighborhood Hits	118	Target Neighborhood Hits	115	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

SCN2A_HUMAN
θ value	1.22964e-73 (rank : 16)	NC score	0.846277 (rank : 25)
Query Neighborhood Hits	118	Target Neighborhood Hits	157	Shared Neighborhood Hits	58
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

CAC1H_HUMAN
θ value	1.35953e-72 (rank : 17)	NC score	0.872910 (rank : 16)
Query Neighborhood Hits	118	Target Neighborhood Hits	307	Shared Neighborhood Hits	66
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

SC10A_MOUSE
θ value	1.35953e-72 (rank : 18)	NC score	0.847988 (rank : 24)
Query Neighborhood Hits	118	Target Neighborhood Hits	107	Shared Neighborhood Hits	62
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

SCN9A_HUMAN
θ value	1.35953e-72 (rank : 19)	NC score	0.845888 (rank : 26)
Query Neighborhood Hits	118	Target Neighborhood Hits	157	Shared Neighborhood Hits	61
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

SCN4A_HUMAN
θ value	5.1662e-72 (rank : 20)	NC score	0.856105 (rank : 21)
Query Neighborhood Hits	118	Target Neighborhood Hits	133	Shared Neighborhood Hits	66
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

SCN1A_HUMAN
θ value	1.96316e-71 (rank : 21)	NC score	0.843867 (rank : 28)
Query Neighborhood Hits	118	Target Neighborhood Hits	148	Shared Neighborhood Hits	60
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SCN8A_HUMAN
θ value	1.96316e-71 (rank : 22)	NC score	0.845320 (rank : 27)
Query Neighborhood Hits	118	Target Neighborhood Hits	135	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN8A_MOUSE
θ value	4.37348e-71 (rank : 23)	NC score	0.842738 (rank : 30)
Query Neighborhood Hits	118	Target Neighborhood Hits	136	Shared Neighborhood Hits	60
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

CAC1H_MOUSE
θ value	7.45998e-71 (rank : 24)	NC score	0.876504 (rank : 15)
Query Neighborhood Hits	118	Target Neighborhood Hits	230	Shared Neighborhood Hits	64
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

CAC1I_HUMAN
θ value	1.27248e-70 (rank : 25)	NC score	0.900685 (rank : 14)
Query Neighborhood Hits	118	Target Neighborhood Hits	138	Shared Neighborhood Hits	62
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

CAC1G_HUMAN
θ value	4.83544e-70 (rank : 26)	NC score	0.856943 (rank : 20)
Query Neighborhood Hits	118	Target Neighborhood Hits	587	Shared Neighborhood Hits	65
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

SC11A_HUMAN
θ value	1.07722e-69 (rank : 27)	NC score	0.864535 (rank : 18)
Query Neighborhood Hits	118	Target Neighborhood Hits	111	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

SCN5A_HUMAN
θ value	1.83746e-69 (rank : 28)	NC score	0.857788 (rank : 19)
Query Neighborhood Hits	118	Target Neighborhood Hits	145	Shared Neighborhood Hits	60
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

SC10A_HUMAN
θ value	3.13423e-69 (rank : 29)	NC score	0.843201 (rank : 29)
Query Neighborhood Hits	118	Target Neighborhood Hits	116	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

SCN7A_HUMAN
θ value	1.36585e-56 (rank : 30)	NC score	0.855685 (rank : 22)
Query Neighborhood Hits	118	Target Neighborhood Hits	135	Shared Neighborhood Hits	56
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

PK2L2_HUMAN
θ value	1.38499e-08 (rank : 31)	NC score	0.384016 (rank : 31)
Query Neighborhood Hits	118	Target Neighborhood Hits	90	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PK2L2_MOUSE
θ value	1.53129e-07 (rank : 32)	NC score	0.347207 (rank : 33)
Query Neighborhood Hits	118	Target Neighborhood Hits	84	Shared Neighborhood Hits	37
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

KCNB1_HUMAN
θ value	7.59969e-07 (rank : 33)	NC score	0.213791 (rank : 41)
Query Neighborhood Hits	118	Target Neighborhood Hits	169	Shared Neighborhood Hits	58
SwissProt Accessions	Q14721, Q14193	Gene names	KCNB1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (h-DRK1).

KCNB1_MOUSE
θ value	7.59969e-07 (rank : 34)	NC score	0.213903 (rank : 40)
Query Neighborhood Hits	118	Target Neighborhood Hits	154	Shared Neighborhood Hits	59
SwissProt Accessions	Q03717	Gene names	Kcnb1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (mShab).

KCNB2_HUMAN
θ value	4.92598e-06 (rank : 35)	NC score	0.225777 (rank : 38)
Query Neighborhood Hits	118	Target Neighborhood Hits	212	Shared Neighborhood Hits	61
SwissProt Accessions	Q92953, Q9BXD3	Gene names	KCNB2
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2).

KCNF1_HUMAN
θ value	8.40245e-06 (rank : 36)	NC score	0.254690 (rank : 36)
Query Neighborhood Hits	118	Target Neighborhood Hits	109	Shared Neighborhood Hits	58
SwissProt Accessions	Q9H3M0, O43527	Gene names	KCNF1
Domain Architecture
Description	Potassium voltage-gated channel subfamily F member 1 (Voltage-gated potassium channel subunit Kv5.1) (kH1).

PKD2_HUMAN
θ value	3.19293e-05 (rank : 37)	NC score	0.327781 (rank : 35)
Query Neighborhood Hits	118	Target Neighborhood Hits	105	Shared Neighborhood Hits	37
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

PK2L1_HUMAN
θ value	9.29e-05 (rank : 38)	NC score	0.347683 (rank : 32)
Query Neighborhood Hits	118	Target Neighborhood Hits	132	Shared Neighborhood Hits	38
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

PKD2_MOUSE
θ value	9.29e-05 (rank : 39)	NC score	0.333459 (rank : 34)
Query Neighborhood Hits	118	Target Neighborhood Hits	99	Shared Neighborhood Hits	39
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

KCNV2_HUMAN
θ value	0.000270298 (rank : 40)	NC score	0.242233 (rank : 37)
Query Neighborhood Hits	118	Target Neighborhood Hits	137	Shared Neighborhood Hits	57
SwissProt Accessions	Q8TDN2	Gene names	KCNV2
Domain Architecture
Description	Potassium voltage-gated channel subfamily V member 2 (Voltage-gated potassium channel subunit Kv8.2).

KCNS1_HUMAN
θ value	0.00134147 (rank : 41)	NC score	0.165063 (rank : 50)
Query Neighborhood Hits	118	Target Neighborhood Hits	116	Shared Neighborhood Hits	57
SwissProt Accessions	Q96KK3, O43652, Q6DJU6	Gene names	KCNS1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

KCNS1_MOUSE
θ value	0.00134147 (rank : 42)	NC score	0.154226 (rank : 51)
Query Neighborhood Hits	118	Target Neighborhood Hits	114	Shared Neighborhood Hits	51
SwissProt Accessions	O35173	Gene names	Kcns1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

KCNA2_HUMAN
θ value	0.00298849 (rank : 43)	NC score	0.092886 (rank : 65)
Query Neighborhood Hits	118	Target Neighborhood Hits	101	Shared Neighborhood Hits	38
SwissProt Accessions	P16389	Gene names	KCNA2
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (HBK5) (NGK1) (HUKIV).

KCNA2_MOUSE
θ value	0.00298849 (rank : 44)	NC score	0.093876 (rank : 63)
Query Neighborhood Hits	118	Target Neighborhood Hits	102	Shared Neighborhood Hits	39
SwissProt Accessions	P63141, P15386, Q02010, Q8C8W4	Gene names	Kcna2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (MK2).

KCNS2_HUMAN
θ value	0.00390308 (rank : 45)	NC score	0.213601 (rank : 42)
Query Neighborhood Hits	118	Target Neighborhood Hits	129	Shared Neighborhood Hits	58
SwissProt Accessions	Q9ULS6	Gene names	KCNS2, KIAA1144
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNS2_MOUSE
θ value	0.00390308 (rank : 46)	NC score	0.217154 (rank : 39)
Query Neighborhood Hits	118	Target Neighborhood Hits	130	Shared Neighborhood Hits	59
SwissProt Accessions	O35174, Q543P3	Gene names	Kcns2
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNS3_HUMAN
θ value	0.00509761 (rank : 47)	NC score	0.190012 (rank : 43)
Query Neighborhood Hits	118	Target Neighborhood Hits	125	Shared Neighborhood Hits	57
SwissProt Accessions	Q9BQ31, O43651, Q96B56	Gene names	KCNS3
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 3 (Voltage-gated potassium channel subunit Kv9.3) (Delayed-rectifier K(+) channel alpha subunit 3).

DJBP_MOUSE
θ value	0.0148317 (rank : 48)	NC score	0.062902 (rank : 83)
Query Neighborhood Hits	118	Target Neighborhood Hits	152	Shared Neighborhood Hits	13
SwissProt Accessions	Q6P1E8, Q5DTV8, Q6PGK8, Q9D2D8	Gene names	Djbp, Kiaa1672
Domain Architecture	No domain graphic available
Description	DJ-1-binding protein.

GPTC8_HUMAN
θ value	0.0736092 (rank : 49)	NC score	0.034247 (rank : 92)
Query Neighborhood Hits	118	Target Neighborhood Hits	366	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UKJ3, O60300	Gene names	GPATC8, KIAA0553
Domain Architecture	No domain graphic available
Description	G patch domain-containing protein 8.

KCND1_MOUSE
θ value	0.125558 (rank : 50)	NC score	0.170721 (rank : 48)
Query Neighborhood Hits	118	Target Neighborhood Hits	165	Shared Neighborhood Hits	58
SwissProt Accessions	Q03719, Q8CC68	Gene names	Kcnd1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1) (mShal).

KCNG3_MOUSE
θ value	0.125558 (rank : 51)	NC score	0.118368 (rank : 60)
Query Neighborhood Hits	118	Target Neighborhood Hits	91	Shared Neighborhood Hits	45
SwissProt Accessions	P59053	Gene names	Kcng3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

KCND3_HUMAN
θ value	0.21417 (rank : 52)	NC score	0.186314 (rank : 45)
Query Neighborhood Hits	118	Target Neighborhood Hits	162	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UK17, O60576, O60577, Q5T0M0, Q9UH85, Q9UH86, Q9UK16	Gene names	KCND3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCND3_MOUSE
θ value	0.21417 (rank : 53)	NC score	0.186481 (rank : 44)
Query Neighborhood Hits	118	Target Neighborhood Hits	162	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Z0V1, Q8CC44, Q9Z0V0	Gene names	Kcnd3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

DPOLZ_HUMAN
θ value	0.279714 (rank : 54)	NC score	0.014932 (rank : 98)
Query Neighborhood Hits	118	Target Neighborhood Hits	200	Shared Neighborhood Hits	4
SwissProt Accessions	O60673, O43214	Gene names	REV3L, POLZ, REV3
Domain Architecture
Description	DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (hREV3).

KCNG3_HUMAN
θ value	0.279714 (rank : 55)	NC score	0.119591 (rank : 59)
Query Neighborhood Hits	118	Target Neighborhood Hits	91	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TAE7	Gene names	KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

KCND1_HUMAN
θ value	0.365318 (rank : 56)	NC score	0.166703 (rank : 49)
Query Neighborhood Hits	118	Target Neighborhood Hits	160	Shared Neighborhood Hits	57
SwissProt Accessions	Q9NSA2, O75671	Gene names	KCND1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1).

KCND2_HUMAN
θ value	0.365318 (rank : 57)	NC score	0.180238 (rank : 47)
Query Neighborhood Hits	118	Target Neighborhood Hits	154	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NZV8, O95012, O95021, Q9UBY7, Q9UN98, Q9UNH9	Gene names	KCND2, KIAA1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND2_MOUSE
θ value	0.365318 (rank : 58)	NC score	0.180396 (rank : 46)
Query Neighborhood Hits	118	Target Neighborhood Hits	156	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Z0V2, Q8BSK3, Q8CHB7, Q9JJ60	Gene names	Kcnd2, Kiaa1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

MLL2_HUMAN
θ value	0.365318 (rank : 59)	NC score	0.014845 (rank : 99)
Query Neighborhood Hits	118	Target Neighborhood Hits	1788	Shared Neighborhood Hits	27
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

TARA_HUMAN
θ value	0.813845 (rank : 60)	NC score	0.022785 (rank : 95)
Query Neighborhood Hits	118	Target Neighborhood Hits	1626	Shared Neighborhood Hits	29
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

ARHGC_MOUSE
θ value	1.38821 (rank : 61)	NC score	0.004172 (rank : 125)
Query Neighborhood Hits	118	Target Neighborhood Hits	344	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

EPC2_HUMAN
θ value	1.38821 (rank : 62)	NC score	0.009594 (rank : 105)
Query Neighborhood Hits	118	Target Neighborhood Hits	58	Shared Neighborhood Hits	2
SwissProt Accessions	Q52LR7, Q7L9J1, Q96RR7, Q9NUT8, Q9NVR1, Q9UFM9	Gene names	EPC2
Domain Architecture	No domain graphic available
Description	Enhancer of polycomb homolog 2.

KCNC4_HUMAN
θ value	1.38821 (rank : 63)	NC score	0.135797 (rank : 54)
Query Neighborhood Hits	118	Target Neighborhood Hits	141	Shared Neighborhood Hits	54
SwissProt Accessions	Q03721, Q3MIM4, Q5TBI6	Gene names	KCNC4
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4) (KSHIIIC).

LEO1_MOUSE
θ value	1.38821 (rank : 64)	NC score	0.009201 (rank : 107)
Query Neighborhood Hits	118	Target Neighborhood Hits	946	Shared Neighborhood Hits	15
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

PLMN_MOUSE
θ value	1.38821 (rank : 65)	NC score	0.000123 (rank : 137)
Query Neighborhood Hits	118	Target Neighborhood Hits	208	Shared Neighborhood Hits	2
SwissProt Accessions	P20918, Q8CIS2, Q91WJ5	Gene names	Plg
Domain Architecture
Description	Plasminogen precursor (EC 3.4.21.7) [Contains: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B].

DOCK4_HUMAN
θ value	1.81305 (rank : 66)	NC score	0.009492 (rank : 106)
Query Neighborhood Hits	118	Target Neighborhood Hits	237	Shared Neighborhood Hits	9
SwissProt Accessions	Q8N1I0, O14584, O94824, Q8NB45	Gene names	DOCK4, KIAA0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

DOCK4_MOUSE
θ value	1.81305 (rank : 67)	NC score	0.010487 (rank : 103)
Query Neighborhood Hits	118	Target Neighborhood Hits	210	Shared Neighborhood Hits	9
SwissProt Accessions	P59764	Gene names	Dock4, Kiaa0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

KCNC4_MOUSE
θ value	1.81305 (rank : 68)	NC score	0.127480 (rank : 55)
Query Neighborhood Hits	118	Target Neighborhood Hits	130	Shared Neighborhood Hits	53
SwissProt Accessions	Q8R1C0	Gene names	Kcnc4
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4).

KCNG1_HUMAN
θ value	1.81305 (rank : 69)	NC score	0.087686 (rank : 67)
Query Neighborhood Hits	118	Target Neighborhood Hits	103	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UIX4, O43528, Q9BRC1	Gene names	KCNG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 1 (Voltage-gated potassium channel subunit Kv6.1) (kH2).

TP53B_HUMAN
θ value	1.81305 (rank : 70)	NC score	0.016637 (rank : 96)
Query Neighborhood Hits	118	Target Neighborhood Hits	413	Shared Neighborhood Hits	13
SwissProt Accessions	Q12888, Q2M1Z7, Q4LE46, Q5FWZ3, Q7Z3U4	Gene names	TP53BP1
Domain Architecture
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

TRPV3_HUMAN
θ value	1.81305 (rank : 71)	NC score	0.056284 (rank : 86)
Query Neighborhood Hits	118	Target Neighborhood Hits	198	Shared Neighborhood Hits	26
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

CABL2_HUMAN
θ value	2.36792 (rank : 72)	NC score	0.008432 (rank : 109)
Query Neighborhood Hits	118	Target Neighborhood Hits	84	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BTV7, Q5JWL0, Q9BYK0	Gene names	CABLES2, C20orf150
Domain Architecture
Description	CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2).

E41LB_HUMAN
θ value	2.36792 (rank : 73)	NC score	0.003646 (rank : 127)
Query Neighborhood Hits	118	Target Neighborhood Hits	79	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

GEMI5_HUMAN
θ value	2.36792 (rank : 74)	NC score	0.003725 (rank : 126)
Query Neighborhood Hits	118	Target Neighborhood Hits	362	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TEQ6, Q8WWV4, Q969W4, Q9H9K3, Q9UFI5	Gene names	GEMIN5
Domain Architecture
Description	Gem-associated protein 5 (Gemin5).

CCDC6_HUMAN
θ value	3.0926 (rank : 75)	NC score	0.002027 (rank : 132)
Query Neighborhood Hits	118	Target Neighborhood Hits	723	Shared Neighborhood Hits	8
SwissProt Accessions	Q16204, Q15250	Gene names	CCDC6, D10S170
Domain Architecture
Description	Coiled-coil domain-containing protein 6 (H4 protein) (Papillary thyroid carcinoma-encoded protein).

CD53_MOUSE
θ value	3.0926 (rank : 76)	NC score	0.003600 (rank : 128)
Query Neighborhood Hits	118	Target Neighborhood Hits	52	Shared Neighborhood Hits	2
SwissProt Accessions	Q61451, Q61721	Gene names	Cd53
Domain Architecture
Description	Leukocyte surface antigen CD53 (Cell surface glycoprotein CD53).

KCNC1_HUMAN
θ value	3.0926 (rank : 77)	NC score	0.140939 (rank : 52)
Query Neighborhood Hits	118	Target Neighborhood Hits	133	Shared Neighborhood Hits	54
SwissProt Accessions	P48547	Gene names	KCNC1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

KCNC3_HUMAN
θ value	3.0926 (rank : 78)	NC score	0.123041 (rank : 57)
Query Neighborhood Hits	118	Target Neighborhood Hits	256	Shared Neighborhood Hits	55
SwissProt Accessions	Q14003	Gene names	KCNC3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

KCNC3_MOUSE
θ value	3.0926 (rank : 79)	NC score	0.121572 (rank : 58)
Query Neighborhood Hits	118	Target Neighborhood Hits	173	Shared Neighborhood Hits	53
SwissProt Accessions	Q63959, Q62088	Gene names	Kcnc3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

LIF_MOUSE
θ value	3.0926 (rank : 80)	NC score	0.012841 (rank : 100)
Query Neighborhood Hits	118	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	P09056	Gene names	Lif
Domain Architecture
Description	Leukemia inhibitory factor precursor (LIF) (Differentiation- stimulating factor) (D factor).

NSBP1_MOUSE
θ value	3.0926 (rank : 81)	NC score	0.010883 (rank : 101)
Query Neighborhood Hits	118	Target Neighborhood Hits	681	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JL35, O88832, Q8VC71, Q9CUW1	Gene names	Nsbp1, Garp45
Domain Architecture	No domain graphic available
Description	Nucleosome-binding protein 1 (Nucleosome-binding protein 45) (NBP-45) (GARP45 protein).

RPGR_MOUSE
θ value	3.0926 (rank : 82)	NC score	0.004901 (rank : 122)
Query Neighborhood Hits	118	Target Neighborhood Hits	281	Shared Neighborhood Hits	6
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

TACC2_MOUSE
θ value	3.0926 (rank : 83)	NC score	0.002851 (rank : 129)
Query Neighborhood Hits	118	Target Neighborhood Hits	774	Shared Neighborhood Hits	15
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

AGGF1_HUMAN
θ value	4.03905 (rank : 84)	NC score	0.005966 (rank : 117)
Query Neighborhood Hits	118	Target Neighborhood Hits	271	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N302, O00581, Q53YS3, Q9BU84, Q9NW66	Gene names	AGGF1, VG5Q
Domain Architecture
Description	Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (Vasculogenesis gene on 5q protein) (hVG5Q).

CENPU_HUMAN
θ value	4.03905 (rank : 85)	NC score	0.006478 (rank : 115)
Query Neighborhood Hits	118	Target Neighborhood Hits	289	Shared Neighborhood Hits	4
SwissProt Accessions	Q71F23, Q32Q71, Q9H5G1	Gene names	MLF1IP, CENPU, ICEN24, KLIP1
Domain Architecture	No domain graphic available
Description	Centromere protein U (CENP-U) (CENP-U(50)) (CENP-50) (Interphase centromere complex protein 24) (MLF1-interacting protein) (KSHV latent nuclear antigen-interacting protein 1).

FRS3_MOUSE
θ value	4.03905 (rank : 86)	NC score	0.006550 (rank : 114)
Query Neighborhood Hits	118	Target Neighborhood Hits	168	Shared Neighborhood Hits	5
SwissProt Accessions	Q91WJ0	Gene names	Frs3, Frs2b
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (FRS2-beta).

KCNC1_MOUSE
θ value	4.03905 (rank : 87)	NC score	0.139161 (rank : 53)
Query Neighborhood Hits	118	Target Neighborhood Hits	133	Shared Neighborhood Hits	54
SwissProt Accessions	P15388	Gene names	Kcnc1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

MINT_HUMAN
θ value	4.03905 (rank : 88)	NC score	0.004622 (rank : 124)
Query Neighborhood Hits	118	Target Neighborhood Hits	1291	Shared Neighborhood Hits	23
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

PGFRA_MOUSE
θ value	4.03905 (rank : 89)	NC score	-0.003543 (rank : 140)
Query Neighborhood Hits	118	Target Neighborhood Hits	975	Shared Neighborhood Hits	3
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

PHAR3_HUMAN
θ value	4.03905 (rank : 90)	NC score	0.010847 (rank : 102)
Query Neighborhood Hits	118	Target Neighborhood Hits	169	Shared Neighborhood Hits	8
SwissProt Accessions	Q96KR7, Q707P6, Q9H4T4	Gene names	PHACTR3, C20orf101, SCAPIN1
Domain Architecture	No domain graphic available
Description	Phosphatase and actin regulator 3 (Scapinin) (Scaffold-associated PP1- inhibiting protein).

RPB1_HUMAN
θ value	4.03905 (rank : 91)	NC score	0.006980 (rank : 111)
Query Neighborhood Hits	118	Target Neighborhood Hits	362	Shared Neighborhood Hits	9
SwissProt Accessions	P24928	Gene names	POLR2A
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

RPB1_MOUSE
θ value	4.03905 (rank : 92)	NC score	0.006973 (rank : 112)
Query Neighborhood Hits	118	Target Neighborhood Hits	363	Shared Neighborhood Hits	9
SwissProt Accessions	P08775	Gene names	Polr2a, Rpii215, Rpo2-1
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

SEM5A_MOUSE
θ value	4.03905 (rank : 93)	NC score	0.000462 (rank : 136)
Query Neighborhood Hits	118	Target Neighborhood Hits	162	Shared Neighborhood Hits	2
SwissProt Accessions	Q62217	Gene names	Sema5a, Semaf, SemF
Domain Architecture
Description	Semaphorin-5A precursor (Semaphorin F) (Sema F).

DNL3_HUMAN
θ value	5.27518 (rank : 94)	NC score	0.028453 (rank : 93)
Query Neighborhood Hits	118	Target Neighborhood Hits	49	Shared Neighborhood Hits	8
SwissProt Accessions	P49916, Q16714	Gene names	LIG3
Domain Architecture
Description	DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3).

MCLN3_MOUSE
θ value	5.27518 (rank : 95)	NC score	0.034806 (rank : 91)
Query Neighborhood Hits	118	Target Neighborhood Hits	29	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R4F0, Q8BS73, Q8BSG1, Q8CDB2	Gene names	Mcoln3
Domain Architecture	No domain graphic available
Description	Mucolipin-3.

NOTC1_MOUSE
θ value	5.27518 (rank : 96)	NC score	-0.002943 (rank : 139)
Query Neighborhood Hits	118	Target Neighborhood Hits	916	Shared Neighborhood Hits	8
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

PAD5_MOUSE
θ value	5.27518 (rank : 97)	NC score	0.005687 (rank : 118)
Query Neighborhood Hits	118	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	Q68ED3, Q8C0K6	Gene names	Papd5
Domain Architecture	No domain graphic available
Description	PAP-associated domain-containing protein 5 (EC 2.7.7.-) (Topoisomerase-related function protein 4-2) (TRF4-2).

PHAR3_MOUSE
θ value	5.27518 (rank : 98)	NC score	0.007789 (rank : 110)
Query Neighborhood Hits	118	Target Neighborhood Hits	206	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BYK5, Q8BYS8, Q8C058, Q9DB87	Gene names	Phactr3, Scapin1
Domain Architecture	No domain graphic available
Description	Phosphatase and actin regulator 3 (Scapinin) (Scaffold-associated PP1- inhibiting protein).

PPA5_HUMAN
θ value	5.27518 (rank : 99)	NC score	0.008547 (rank : 108)
Query Neighborhood Hits	118	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	P13686, Q6IAS6	Gene names	ACP5
Domain Architecture
Description	Tartrate-resistant acid phosphatase type 5 precursor (EC 3.1.3.2) (TR- AP) (Tartrate-resistant acid ATPase) (TrATPase) (Acid phosphatase 5, tartrate resistant).

RPTN_MOUSE
θ value	5.27518 (rank : 100)	NC score	0.010340 (rank : 104)
Query Neighborhood Hits	118	Target Neighborhood Hits	650	Shared Neighborhood Hits	17
SwissProt Accessions	P97347	Gene names	Rptn
Domain Architecture
Description	Repetin.

ANR38_HUMAN
θ value	6.88961 (rank : 101)	NC score	0.000845 (rank : 135)
Query Neighborhood Hits	118	Target Neighborhood Hits	443	Shared Neighborhood Hits	9
SwissProt Accessions	Q5T7N3, Q6P9A0, Q86T71, Q86VE6, Q8NAX3	Gene names	ANKRD38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

BAT2_HUMAN
θ value	6.88961 (rank : 102)	NC score	0.016123 (rank : 97)
Query Neighborhood Hits	118	Target Neighborhood Hits	931	Shared Neighborhood Hits	18
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

DNL3_MOUSE
θ value	6.88961 (rank : 103)	NC score	0.025251 (rank : 94)
Query Neighborhood Hits	118	Target Neighborhood Hits	37	Shared Neighborhood Hits	7
SwissProt Accessions	P97386, P97385	Gene names	Lig3
Domain Architecture
Description	DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3).

FGD6_MOUSE
θ value	6.88961 (rank : 104)	NC score	0.000898 (rank : 134)
Query Neighborhood Hits	118	Target Neighborhood Hits	282	Shared Neighborhood Hits	5
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

PGFRA_HUMAN
θ value	6.88961 (rank : 105)	NC score	-0.003833 (rank : 142)
Query Neighborhood Hits	118	Target Neighborhood Hits	980	Shared Neighborhood Hits	3
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

WBS14_MOUSE
θ value	6.88961 (rank : 106)	NC score	0.004997 (rank : 121)
Query Neighborhood Hits	118	Target Neighborhood Hits	171	Shared Neighborhood Hits	8
SwissProt Accessions	Q99MZ3, Q99MY9, Q99MZ0, Q99MZ1, Q99MZ2, Q9JLM5	Gene names	Mlxipl, Mio, Wbscr14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein homolog (Mlx interactor) (MLX-interacting protein-like).

ARI5B_HUMAN
θ value	8.99809 (rank : 107)	NC score	0.002719 (rank : 130)
Query Neighborhood Hits	118	Target Neighborhood Hits	328	Shared Neighborhood Hits	5
SwissProt Accessions	Q14865, Q7Z3M4, Q8N421, Q9H786	Gene names	ARID5B, DESRT, MRF2
Domain Architecture
Description	AT-rich interactive domain-containing protein 5B (ARID domain- containing protein 5B) (Mrf1-like) (Modulator recognition factor 2) (MRF-2).

CABP4_HUMAN
θ value	8.99809 (rank : 108)	NC score	0.006185 (rank : 116)
Query Neighborhood Hits	118	Target Neighborhood Hits	250	Shared Neighborhood Hits	5
SwissProt Accessions	P57796, Q8N4Z2, Q8WWY5	Gene names	CABP4
Domain Architecture
Description	Calcium-binding protein 4 (CaBP4).

CP135_MOUSE
θ value	8.99809 (rank : 109)	NC score	-0.003750 (rank : 141)
Query Neighborhood Hits	118	Target Neighborhood Hits	1278	Shared Neighborhood Hits	10
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

EP400_MOUSE
θ value	8.99809 (rank : 110)	NC score	0.002033 (rank : 131)
Query Neighborhood Hits	118	Target Neighborhood Hits	592	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

KCNA1_MOUSE
θ value	8.99809 (rank : 111)	NC score	0.095321 (rank : 62)
Query Neighborhood Hits	118	Target Neighborhood Hits	103	Shared Neighborhood Hits	42
SwissProt Accessions	P16388	Gene names	Kcna1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (MKI) (MBK1).

KI21A_MOUSE
θ value	8.99809 (rank : 112)	NC score	-0.001204 (rank : 138)
Query Neighborhood Hits	118	Target Neighborhood Hits	1317	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QXL2, Q6P5H1, Q6ZPJ8, Q8BWZ9, Q8BXF1	Gene names	Kif21a, Kiaa1708
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A.

S61A2_HUMAN
θ value	8.99809 (rank : 113)	NC score	0.005162 (rank : 119)
Query Neighborhood Hits	118	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H9S3	Gene names	SEC61A2
Domain Architecture
Description	Protein transport protein Sec61 subunit alpha isoform 2 (Sec61 alpha- 2).

S61A2_MOUSE
θ value	8.99809 (rank : 114)	NC score	0.005162 (rank : 120)
Query Neighborhood Hits	118	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JLR1	Gene names	Sec61a2
Domain Architecture
Description	Protein transport protein Sec61 subunit alpha isoform 2 (Sec61 alpha- 2).

SRCH_HUMAN
θ value	8.99809 (rank : 115)	NC score	0.006879 (rank : 113)
Query Neighborhood Hits	118	Target Neighborhood Hits	225	Shared Neighborhood Hits	7
SwissProt Accessions	P23327, Q504Y6	Gene names	HRC, HCP
Domain Architecture	No domain graphic available
Description	Sarcoplasmic reticulum histidine-rich calcium-binding protein precursor.

SV2C_HUMAN
θ value	8.99809 (rank : 116)	NC score	0.001875 (rank : 133)
Query Neighborhood Hits	118	Target Neighborhood Hits	124	Shared Neighborhood Hits	5
SwissProt Accessions	Q496J9, Q496K1, Q9UPU8	Gene names	SV2C, KIAA1054
Domain Architecture	No domain graphic available
Description	Synaptic vesicle glycoprotein 2C.

TMC2_HUMAN
θ value	8.99809 (rank : 117)	NC score	0.004701 (rank : 123)
Query Neighborhood Hits	118	Target Neighborhood Hits	149	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TDI7, Q5JXT0, Q5JXT1, Q6UWW4, Q6ZS41, Q8N9F3, Q9BYN2, Q9BYN3, Q9BYN4, Q9BYN5	Gene names	TMC2
Domain Architecture	No domain graphic available
Description	Transmembrane cochlear-expressed protein 2.

TRPV3_MOUSE
θ value	8.99809 (rank : 118)	NC score	0.036707 (rank : 90)
Query Neighborhood Hits	118	Target Neighborhood Hits	188	Shared Neighborhood Hits	22
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

KCNA1_HUMAN
θ value	θ > 10 (rank : 119)	NC score	0.093159 (rank : 64)
Query Neighborhood Hits	118	Target Neighborhood Hits	104	Shared Neighborhood Hits	41
SwissProt Accessions	Q09470	Gene names	KCNA1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (HUKI) (HBK1).

KCNA3_HUMAN
θ value	θ > 10 (rank : 120)	NC score	0.079699 (rank : 73)
Query Neighborhood Hits	118	Target Neighborhood Hits	101	Shared Neighborhood Hits	37
SwissProt Accessions	P22001	Gene names	KCNA3, HGK5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3).

KCNA3_MOUSE
θ value	θ > 10 (rank : 121)	NC score	0.078796 (rank : 75)
Query Neighborhood Hits	118	Target Neighborhood Hits	103	Shared Neighborhood Hits	35
SwissProt Accessions	P16390	Gene names	Kcna3
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (MK3).

KCNA4_HUMAN
θ value	θ > 10 (rank : 122)	NC score	0.069408 (rank : 79)
Query Neighborhood Hits	118	Target Neighborhood Hits	108	Shared Neighborhood Hits	32
SwissProt Accessions	P22459	Gene names	KCNA4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4) (HK1) (HPCN2) (HBK4) (HUKII).

KCNA4_MOUSE
θ value	θ > 10 (rank : 123)	NC score	0.069629 (rank : 78)
Query Neighborhood Hits	118	Target Neighborhood Hits	98	Shared Neighborhood Hits	32
SwissProt Accessions	Q61423	Gene names	Kcna4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4).

KCNA5_HUMAN
θ value	θ > 10 (rank : 124)	NC score	0.076481 (rank : 77)
Query Neighborhood Hits	118	Target Neighborhood Hits	124	Shared Neighborhood Hits	34
SwissProt Accessions	P22460	Gene names	KCNA5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (HK2) (HPCN1).

KCNA5_MOUSE
θ value	θ > 10 (rank : 125)	NC score	0.081410 (rank : 72)
Query Neighborhood Hits	118	Target Neighborhood Hits	119	Shared Neighborhood Hits	38
SwissProt Accessions	Q61762	Gene names	Kcna5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (KV1-5).

KCNA6_HUMAN
θ value	θ > 10 (rank : 126)	NC score	0.083856 (rank : 71)
Query Neighborhood Hits	118	Target Neighborhood Hits	100	Shared Neighborhood Hits	38
SwissProt Accessions	P17658	Gene names	KCNA6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (HBK2).

KCNA6_MOUSE
θ value	θ > 10 (rank : 127)	NC score	0.090171 (rank : 66)
Query Neighborhood Hits	118	Target Neighborhood Hits	106	Shared Neighborhood Hits	41
SwissProt Accessions	Q61923	Gene names	Kcna6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (MK1.6).

KCNG2_HUMAN
θ value	θ > 10 (rank : 128)	NC score	0.084035 (rank : 70)
Query Neighborhood Hits	118	Target Neighborhood Hits	83	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UJ96	Gene names	KCNG2, KCNF2
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 2 (Voltage-gated potassium channel subunit Kv6.2) (Cardiac potassium channel subunit).

KCNG4_HUMAN
θ value	θ > 10 (rank : 129)	NC score	0.078898 (rank : 74)
Query Neighborhood Hits	118	Target Neighborhood Hits	99	Shared Neighborhood Hits	30
SwissProt Accessions	Q8TDN1, Q96H24	Gene names	KCNG4, KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 4 (Voltage-gated potassium channel subunit Kv6.4).

KCNQ1_HUMAN
θ value	θ > 10 (rank : 130)	NC score	0.063882 (rank : 81)
Query Neighborhood Hits	118	Target Neighborhood Hits	99	Shared Neighborhood Hits	35
SwissProt Accessions	P51787, O00347, O60607, O94787, Q7Z6G9, Q92960, Q9UMN8, Q9UMN9	Gene names	KCNQ1, KCNA8, KCNA9, KVLQT1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

KCNQ1_MOUSE
θ value	θ > 10 (rank : 131)	NC score	0.076542 (rank : 76)
Query Neighborhood Hits	118	Target Neighborhood Hits	175	Shared Neighborhood Hits	41
SwissProt Accessions	P97414, O88702, Q7TNZ1, Q7TPL7, Q80VR7	Gene names	Kcnq1, Kcna9, Kvlqt1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

KCNQ2_HUMAN
θ value	θ > 10 (rank : 132)	NC score	0.059596 (rank : 85)
Query Neighborhood Hits	118	Target Neighborhood Hits	114	Shared Neighborhood Hits	33
SwissProt Accessions	O43526, O43796, O75580, O95845, Q5VYT8, Q96J59, Q99454	Gene names	KCNQ2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (KQT-like 2).

KCNQ2_MOUSE
θ value	θ > 10 (rank : 133)	NC score	0.055860 (rank : 87)
Query Neighborhood Hits	118	Target Neighborhood Hits	163	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Z351, Q8R498, Q9QWN9, Q9Z342, Q9Z343, Q9Z344, Q9Z345, Q9Z346, Q9Z347, Q9Z348, Q9Z349, Q9Z350	Gene names	Kcnq2, Kqt2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Potassium channel subunit alpha KvLQT2) (KQT-like 2).

KCNQ3_HUMAN
θ value	θ > 10 (rank : 134)	NC score	0.054097 (rank : 88)
Query Neighborhood Hits	118	Target Neighborhood Hits	114	Shared Neighborhood Hits	36
SwissProt Accessions	O43525	Gene names	KCNQ3
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

KCNQ3_MOUSE
θ value	θ > 10 (rank : 135)	NC score	0.053083 (rank : 89)
Query Neighborhood Hits	118	Target Neighborhood Hits	105	Shared Neighborhood Hits	36
SwissProt Accessions	Q8K3F6	Gene names	Kcnq3
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

KCNQ4_HUMAN
θ value	θ > 10 (rank : 136)	NC score	0.087512 (rank : 68)
Query Neighborhood Hits	118	Target Neighborhood Hits	136	Shared Neighborhood Hits	42
SwissProt Accessions	P56696, O96025	Gene names	KCNQ4
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4).

KCNQ5_HUMAN
θ value	θ > 10 (rank : 137)	NC score	0.063403 (rank : 82)
Query Neighborhood Hits	118	Target Neighborhood Hits	163	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NR82, Q9NRN0, Q9NYA6	Gene names	KCNQ5
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 5 (Voltage-gated potassium channel subunit Kv7.5) (Potassium channel subunit alpha KvLQT5) (KQT-like 5).

MCLN2_MOUSE
θ value	θ > 10 (rank : 138)	NC score	0.060758 (rank : 84)
Query Neighborhood Hits	118	Target Neighborhood Hits	31	Shared Neighborhood Hits	17
SwissProt Accessions	Q8K595, Q3UCG4, Q8K2T6, Q9CQD3	Gene names	Mcoln2
Domain Architecture	No domain graphic available
Description	Mucolipin-2.

PKDRE_HUMAN
θ value	θ > 10 (rank : 139)	NC score	0.097186 (rank : 61)
Query Neighborhood Hits	118	Target Neighborhood Hits	64	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

PKDRE_MOUSE
θ value	θ > 10 (rank : 140)	NC score	0.068896 (rank : 80)
Query Neighborhood Hits	118	Target Neighborhood Hits	76	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

TPTE2_HUMAN
θ value	θ > 10 (rank : 141)	NC score	0.123751 (rank : 56)
Query Neighborhood Hits	118	Target Neighborhood Hits	68	Shared Neighborhood Hits	24
SwissProt Accessions	Q6XPS3, Q5VUH2, Q8WWL4, Q8WWL5	Gene names	TPTE2, TPIP
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (TPTE and PTEN homologous inositol lipid phosphatase) (Lipid phosphatase TPIP).

TPTE_HUMAN
θ value	θ > 10 (rank : 142)	NC score	0.084116 (rank : 69)
Query Neighborhood Hits	118	Target Neighborhood Hits	53	Shared Neighborhood Hits	22
SwissProt Accessions	P56180, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8	Gene names	TPTE
Domain Architecture
Description	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Transmembrane phosphatase with tensin homology) (Protein BJ-HCC-5).

Hits sorted by NC score

CAC1D_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 7)
Query Neighborhood Hits	118	Target Neighborhood Hits	118	Shared Neighborhood Hits	118
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

CAC1S_HUMAN
NC score	0.995599 (rank : 2)	θ value	0 (rank : 12)
Query Neighborhood Hits	118	Target Neighborhood Hits	92	Shared Neighborhood Hits	60
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1S_MOUSE
NC score	0.994651 (rank : 3)	θ value	0 (rank : 13)
Query Neighborhood Hits	118	Target Neighborhood Hits	98	Shared Neighborhood Hits	62
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1C_MOUSE
NC score	0.994293 (rank : 4)	θ value	0 (rank : 6)
Query Neighborhood Hits	118	Target Neighborhood Hits	130	Shared Neighborhood Hits	60
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

CAC1F_MOUSE
NC score	0.993541 (rank : 5)	θ value	0 (rank : 11)
Query Neighborhood Hits	118	Target Neighborhood Hits	142	Shared Neighborhood Hits	64
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1F_HUMAN
NC score	0.993397 (rank : 6)	θ value	0 (rank : 10)
Query Neighborhood Hits	118	Target Neighborhood Hits	141	Shared Neighborhood Hits	63
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1C_HUMAN
NC score	0.993159 (rank : 7)	θ value	0 (rank : 5)
Query Neighborhood Hits	118	Target Neighborhood Hits	158	Shared Neighborhood Hits	59
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

CAC1E_MOUSE
NC score	0.959422 (rank : 8)	θ value	0 (rank : 9)
Query Neighborhood Hits	118	Target Neighborhood Hits	167	Shared Neighborhood Hits	58
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1E_HUMAN
NC score	0.959340 (rank : 9)	θ value	0 (rank : 8)
Query Neighborhood Hits	118	Target Neighborhood Hits	148	Shared Neighborhood Hits	58
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1B_HUMAN
NC score	0.955878 (rank : 10)	θ value	0 (rank : 3)
Query Neighborhood Hits	118	Target Neighborhood Hits	257	Shared Neighborhood Hits	59
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1A_MOUSE
NC score	0.955621 (rank : 11)	θ value	0 (rank : 2)
Query Neighborhood Hits	118	Target Neighborhood Hits	267	Shared Neighborhood Hits	64
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1B_MOUSE
NC score	0.951249 (rank : 12)	θ value	0 (rank : 4)
Query Neighborhood Hits	118	Target Neighborhood Hits	351	Shared Neighborhood Hits	63
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1A_HUMAN
NC score	0.946986 (rank : 13)	θ value	0 (rank : 1)
Query Neighborhood Hits	118	Target Neighborhood Hits	387	Shared Neighborhood Hits	63
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1I_HUMAN
NC score	0.900685 (rank : 14)	θ value	1.27248e-70 (rank : 25)
Query Neighborhood Hits	118	Target Neighborhood Hits	138	Shared Neighborhood Hits	62
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

CAC1H_MOUSE
NC score	0.876504 (rank : 15)	θ value	7.45998e-71 (rank : 24)
Query Neighborhood Hits	118	Target Neighborhood Hits	230	Shared Neighborhood Hits	64
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

CAC1H_HUMAN
NC score	0.872910 (rank : 16)	θ value	1.35953e-72 (rank : 17)
Query Neighborhood Hits	118	Target Neighborhood Hits	307	Shared Neighborhood Hits	66
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

SC11A_MOUSE
NC score	0.866604 (rank : 17)	θ value	7.93343e-89 (rank : 14)
Query Neighborhood Hits	118	Target Neighborhood Hits	116	Shared Neighborhood Hits	65
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

SC11A_HUMAN
NC score	0.864535 (rank : 18)	θ value	1.07722e-69 (rank : 27)
Query Neighborhood Hits	118	Target Neighborhood Hits	111	Shared Neighborhood Hits	63
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

SCN5A_HUMAN
NC score	0.857788 (rank : 19)	θ value	1.83746e-69 (rank : 28)
Query Neighborhood Hits	118	Target Neighborhood Hits	145	Shared Neighborhood Hits	60
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

CAC1G_HUMAN
NC score	0.856943 (rank : 20)	θ value	4.83544e-70 (rank : 26)
Query Neighborhood Hits	118	Target Neighborhood Hits	587	Shared Neighborhood Hits	65
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

SCN4A_HUMAN
NC score	0.856105 (rank : 21)	θ value	5.1662e-72 (rank : 20)
Query Neighborhood Hits	118	Target Neighborhood Hits	133	Shared Neighborhood Hits	66
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

SCN7A_HUMAN
NC score	0.855685 (rank : 22)	θ value	1.36585e-56 (rank : 30)
Query Neighborhood Hits	118	Target Neighborhood Hits	135	Shared Neighborhood Hits	56
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

SCN3A_HUMAN
NC score	0.849178 (rank : 23)	θ value	3.23591e-74 (rank : 15)
Query Neighborhood Hits	118	Target Neighborhood Hits	115	Shared Neighborhood Hits	59
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

SC10A_MOUSE
NC score	0.847988 (rank : 24)	θ value	1.35953e-72 (rank : 18)
Query Neighborhood Hits	118	Target Neighborhood Hits	107	Shared Neighborhood Hits	62
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

SCN2A_HUMAN
NC score	0.846277 (rank : 25)	θ value	1.22964e-73 (rank : 16)
Query Neighborhood Hits	118	Target Neighborhood Hits	157	Shared Neighborhood Hits	58
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

SCN9A_HUMAN
NC score	0.845888 (rank : 26)	θ value	1.35953e-72 (rank : 19)
Query Neighborhood Hits	118	Target Neighborhood Hits	157	Shared Neighborhood Hits	61
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

SCN8A_HUMAN
NC score	0.845320 (rank : 27)	θ value	1.96316e-71 (rank : 22)
Query Neighborhood Hits	118	Target Neighborhood Hits	135	Shared Neighborhood Hits	59
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN1A_HUMAN
NC score	0.843867 (rank : 28)	θ value	1.96316e-71 (rank : 21)
Query Neighborhood Hits	118	Target Neighborhood Hits	148	Shared Neighborhood Hits	60
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SC10A_HUMAN
NC score	0.843201 (rank : 29)	θ value	3.13423e-69 (rank : 29)
Query Neighborhood Hits	118	Target Neighborhood Hits	116	Shared Neighborhood Hits	57
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

SCN8A_MOUSE
NC score	0.842738 (rank : 30)	θ value	4.37348e-71 (rank : 23)
Query Neighborhood Hits	118	Target Neighborhood Hits	136	Shared Neighborhood Hits	60
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

PK2L2_HUMAN
NC score	0.384016 (rank : 31)	θ value	1.38499e-08 (rank : 31)
Query Neighborhood Hits	118	Target Neighborhood Hits	90	Shared Neighborhood Hits	39
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PK2L1_HUMAN
NC score	0.347683 (rank : 32)	θ value	9.29e-05 (rank : 38)
Query Neighborhood Hits	118	Target Neighborhood Hits	132	Shared Neighborhood Hits	38
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

PK2L2_MOUSE
NC score	0.347207 (rank : 33)	θ value	1.53129e-07 (rank : 32)
Query Neighborhood Hits	118	Target Neighborhood Hits	84	Shared Neighborhood Hits	37
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PKD2_MOUSE
NC score	0.333459 (rank : 34)	θ value	9.29e-05 (rank : 39)
Query Neighborhood Hits	118	Target Neighborhood Hits	99	Shared Neighborhood Hits	39
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

PKD2_HUMAN
NC score	0.327781 (rank : 35)	θ value	3.19293e-05 (rank : 37)
Query Neighborhood Hits	118	Target Neighborhood Hits	105	Shared Neighborhood Hits	37
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

KCNF1_HUMAN
NC score	0.254690 (rank : 36)	θ value	8.40245e-06 (rank : 36)
Query Neighborhood Hits	118	Target Neighborhood Hits	109	Shared Neighborhood Hits	58
SwissProt Accessions	Q9H3M0, O43527	Gene names	KCNF1
Domain Architecture
Description	Potassium voltage-gated channel subfamily F member 1 (Voltage-gated potassium channel subunit Kv5.1) (kH1).

KCNV2_HUMAN
NC score	0.242233 (rank : 37)	θ value	0.000270298 (rank : 40)
Query Neighborhood Hits	118	Target Neighborhood Hits	137	Shared Neighborhood Hits	57
SwissProt Accessions	Q8TDN2	Gene names	KCNV2
Domain Architecture
Description	Potassium voltage-gated channel subfamily V member 2 (Voltage-gated potassium channel subunit Kv8.2).

KCNB2_HUMAN
NC score	0.225777 (rank : 38)	θ value	4.92598e-06 (rank : 35)
Query Neighborhood Hits	118	Target Neighborhood Hits	212	Shared Neighborhood Hits	61
SwissProt Accessions	Q92953, Q9BXD3	Gene names	KCNB2
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 2 (Voltage-gated potassium channel subunit Kv2.2).

KCNS2_MOUSE
NC score	0.217154 (rank : 39)	θ value	0.00390308 (rank : 46)
Query Neighborhood Hits	118	Target Neighborhood Hits	130	Shared Neighborhood Hits	59
SwissProt Accessions	O35174, Q543P3	Gene names	Kcns2
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNB1_MOUSE
NC score	0.213903 (rank : 40)	θ value	7.59969e-07 (rank : 34)
Query Neighborhood Hits	118	Target Neighborhood Hits	154	Shared Neighborhood Hits	59
SwissProt Accessions	Q03717	Gene names	Kcnb1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (mShab).

KCNB1_HUMAN
NC score	0.213791 (rank : 41)	θ value	7.59969e-07 (rank : 33)
Query Neighborhood Hits	118	Target Neighborhood Hits	169	Shared Neighborhood Hits	58
SwissProt Accessions	Q14721, Q14193	Gene names	KCNB1
Domain Architecture
Description	Potassium voltage-gated channel subfamily B member 1 (Voltage-gated potassium channel subunit Kv2.1) (h-DRK1).

KCNS2_HUMAN
NC score	0.213601 (rank : 42)	θ value	0.00390308 (rank : 45)
Query Neighborhood Hits	118	Target Neighborhood Hits	129	Shared Neighborhood Hits	58
SwissProt Accessions	Q9ULS6	Gene names	KCNS2, KIAA1144
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 2 (Voltage-gated potassium channel subunit Kv9.2) (Delayed-rectifier K(+) channel alpha subunit 2).

KCNS3_HUMAN
NC score	0.190012 (rank : 43)	θ value	0.00509761 (rank : 47)
Query Neighborhood Hits	118	Target Neighborhood Hits	125	Shared Neighborhood Hits	57
SwissProt Accessions	Q9BQ31, O43651, Q96B56	Gene names	KCNS3
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 3 (Voltage-gated potassium channel subunit Kv9.3) (Delayed-rectifier K(+) channel alpha subunit 3).

KCND3_MOUSE
NC score	0.186481 (rank : 44)	θ value	0.21417 (rank : 53)
Query Neighborhood Hits	118	Target Neighborhood Hits	162	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Z0V1, Q8CC44, Q9Z0V0	Gene names	Kcnd3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCND3_HUMAN
NC score	0.186314 (rank : 45)	θ value	0.21417 (rank : 52)
Query Neighborhood Hits	118	Target Neighborhood Hits	162	Shared Neighborhood Hits	58
SwissProt Accessions	Q9UK17, O60576, O60577, Q5T0M0, Q9UH85, Q9UH86, Q9UK16	Gene names	KCND3
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3).

KCND2_MOUSE
NC score	0.180396 (rank : 46)	θ value	0.365318 (rank : 58)
Query Neighborhood Hits	118	Target Neighborhood Hits	156	Shared Neighborhood Hits	58
SwissProt Accessions	Q9Z0V2, Q8BSK3, Q8CHB7, Q9JJ60	Gene names	Kcnd2, Kiaa1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND2_HUMAN
NC score	0.180238 (rank : 47)	θ value	0.365318 (rank : 57)
Query Neighborhood Hits	118	Target Neighborhood Hits	154	Shared Neighborhood Hits	58
SwissProt Accessions	Q9NZV8, O95012, O95021, Q9UBY7, Q9UN98, Q9UNH9	Gene names	KCND2, KIAA1044
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2).

KCND1_MOUSE
NC score	0.170721 (rank : 48)	θ value	0.125558 (rank : 50)
Query Neighborhood Hits	118	Target Neighborhood Hits	165	Shared Neighborhood Hits	58
SwissProt Accessions	Q03719, Q8CC68	Gene names	Kcnd1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1) (mShal).

KCND1_HUMAN
NC score	0.166703 (rank : 49)	θ value	0.365318 (rank : 56)
Query Neighborhood Hits	118	Target Neighborhood Hits	160	Shared Neighborhood Hits	57
SwissProt Accessions	Q9NSA2, O75671	Gene names	KCND1
Domain Architecture
Description	Potassium voltage-gated channel subfamily D member 1 (Voltage-gated potassium channel subunit Kv4.1).

KCNS1_HUMAN
NC score	0.165063 (rank : 50)	θ value	0.00134147 (rank : 41)
Query Neighborhood Hits	118	Target Neighborhood Hits	116	Shared Neighborhood Hits	57
SwissProt Accessions	Q96KK3, O43652, Q6DJU6	Gene names	KCNS1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

KCNS1_MOUSE
NC score	0.154226 (rank : 51)	θ value	0.00134147 (rank : 42)
Query Neighborhood Hits	118	Target Neighborhood Hits	114	Shared Neighborhood Hits	51
SwissProt Accessions	O35173	Gene names	Kcns1
Domain Architecture
Description	Potassium voltage-gated channel subfamily S member 1 (Voltage-gated potassium channel subunit Kv9.1) (Delayed-rectifier K(+) channel alpha subunit 1).

KCNC1_HUMAN
NC score	0.140939 (rank : 52)	θ value	3.0926 (rank : 77)
Query Neighborhood Hits	118	Target Neighborhood Hits	133	Shared Neighborhood Hits	54
SwissProt Accessions	P48547	Gene names	KCNC1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

KCNC1_MOUSE
NC score	0.139161 (rank : 53)	θ value	4.03905 (rank : 87)
Query Neighborhood Hits	118	Target Neighborhood Hits	133	Shared Neighborhood Hits	54
SwissProt Accessions	P15388	Gene names	Kcnc1
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 1 (Voltage-gated potassium channel subunit Kv3.1) (Kv4) (NGK2).

KCNC4_HUMAN
NC score	0.135797 (rank : 54)	θ value	1.38821 (rank : 63)
Query Neighborhood Hits	118	Target Neighborhood Hits	141	Shared Neighborhood Hits	54
SwissProt Accessions	Q03721, Q3MIM4, Q5TBI6	Gene names	KCNC4
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4) (KSHIIIC).

KCNC4_MOUSE
NC score	0.127480 (rank : 55)	θ value	1.81305 (rank : 68)
Query Neighborhood Hits	118	Target Neighborhood Hits	130	Shared Neighborhood Hits	53
SwissProt Accessions	Q8R1C0	Gene names	Kcnc4
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily C member 4 (Voltage-gated potassium channel subunit Kv3.4).

TPTE2_HUMAN
NC score	0.123751 (rank : 56)	θ value	θ > 10 (rank : 141)
Query Neighborhood Hits	118	Target Neighborhood Hits	68	Shared Neighborhood Hits	24
SwissProt Accessions	Q6XPS3, Q5VUH2, Q8WWL4, Q8WWL5	Gene names	TPTE2, TPIP
Domain Architecture	No domain graphic available
Description	Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase TPTE2 (EC 3.1.3.67) (TPTE and PTEN homologous inositol lipid phosphatase) (Lipid phosphatase TPIP).

KCNC3_HUMAN
NC score	0.123041 (rank : 57)	θ value	3.0926 (rank : 78)
Query Neighborhood Hits	118	Target Neighborhood Hits	256	Shared Neighborhood Hits	55
SwissProt Accessions	Q14003	Gene names	KCNC3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

KCNC3_MOUSE
NC score	0.121572 (rank : 58)	θ value	3.0926 (rank : 79)
Query Neighborhood Hits	118	Target Neighborhood Hits	173	Shared Neighborhood Hits	53
SwissProt Accessions	Q63959, Q62088	Gene names	Kcnc3
Domain Architecture
Description	Potassium voltage-gated channel subfamily C member 3 (Voltage-gated potassium channel subunit Kv3.3) (KSHIIID).

KCNG3_HUMAN
NC score	0.119591 (rank : 59)	θ value	0.279714 (rank : 55)
Query Neighborhood Hits	118	Target Neighborhood Hits	91	Shared Neighborhood Hits	44
SwissProt Accessions	Q8TAE7	Gene names	KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

KCNG3_MOUSE
NC score	0.118368 (rank : 60)	θ value	0.125558 (rank : 51)
Query Neighborhood Hits	118	Target Neighborhood Hits	91	Shared Neighborhood Hits	45
SwissProt Accessions	P59053	Gene names	Kcng3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 3 (Voltage-gated potassium channel subunit Kv6.3) (Kv10.1).

PKDRE_HUMAN
NC score	0.097186 (rank : 61)	θ value	θ > 10 (rank : 139)
Query Neighborhood Hits	118	Target Neighborhood Hits	64	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

KCNA1_MOUSE
NC score	0.095321 (rank : 62)	θ value	8.99809 (rank : 111)
Query Neighborhood Hits	118	Target Neighborhood Hits	103	Shared Neighborhood Hits	42
SwissProt Accessions	P16388	Gene names	Kcna1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (MKI) (MBK1).

KCNA2_MOUSE
NC score	0.093876 (rank : 63)	θ value	0.00298849 (rank : 44)
Query Neighborhood Hits	118	Target Neighborhood Hits	102	Shared Neighborhood Hits	39
SwissProt Accessions	P63141, P15386, Q02010, Q8C8W4	Gene names	Kcna2
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (MK2).

KCNA1_HUMAN
NC score	0.093159 (rank : 64)	θ value	θ > 10 (rank : 119)
Query Neighborhood Hits	118	Target Neighborhood Hits	104	Shared Neighborhood Hits	41
SwissProt Accessions	Q09470	Gene names	KCNA1
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 1 (Voltage-gated potassium channel subunit Kv1.1) (HUKI) (HBK1).

KCNA2_HUMAN
NC score	0.092886 (rank : 65)	θ value	0.00298849 (rank : 43)
Query Neighborhood Hits	118	Target Neighborhood Hits	101	Shared Neighborhood Hits	38
SwissProt Accessions	P16389	Gene names	KCNA2
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 2 (Voltage-gated potassium channel subunit Kv1.2) (HBK5) (NGK1) (HUKIV).

KCNA6_MOUSE
NC score	0.090171 (rank : 66)	θ value	θ > 10 (rank : 127)
Query Neighborhood Hits	118	Target Neighborhood Hits	106	Shared Neighborhood Hits	41
SwissProt Accessions	Q61923	Gene names	Kcna6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (MK1.6).

KCNG1_HUMAN
NC score	0.087686 (rank : 67)	θ value	1.81305 (rank : 69)
Query Neighborhood Hits	118	Target Neighborhood Hits	103	Shared Neighborhood Hits	36
SwissProt Accessions	Q9UIX4, O43528, Q9BRC1	Gene names	KCNG1
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 1 (Voltage-gated potassium channel subunit Kv6.1) (kH2).

KCNQ4_HUMAN
NC score	0.087512 (rank : 68)	θ value	θ > 10 (rank : 136)
Query Neighborhood Hits	118	Target Neighborhood Hits	136	Shared Neighborhood Hits	42
SwissProt Accessions	P56696, O96025	Gene names	KCNQ4
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 4 (Voltage-gated potassium channel subunit Kv7.4) (Potassium channel subunit alpha KvLQT4) (KQT-like 4).

TPTE_HUMAN
NC score	0.084116 (rank : 69)	θ value	θ > 10 (rank : 142)
Query Neighborhood Hits	118	Target Neighborhood Hits	53	Shared Neighborhood Hits	22
SwissProt Accessions	P56180, Q6XPS4, Q6XPS5, Q71JA8, Q8NCS8	Gene names	TPTE
Domain Architecture
Description	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Transmembrane phosphatase with tensin homology) (Protein BJ-HCC-5).

KCNG2_HUMAN
NC score	0.084035 (rank : 70)	θ value	θ > 10 (rank : 128)
Query Neighborhood Hits	118	Target Neighborhood Hits	83	Shared Neighborhood Hits	30
SwissProt Accessions	Q9UJ96	Gene names	KCNG2, KCNF2
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 2 (Voltage-gated potassium channel subunit Kv6.2) (Cardiac potassium channel subunit).

KCNA6_HUMAN
NC score	0.083856 (rank : 71)	θ value	θ > 10 (rank : 126)
Query Neighborhood Hits	118	Target Neighborhood Hits	100	Shared Neighborhood Hits	38
SwissProt Accessions	P17658	Gene names	KCNA6
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 6 (Voltage-gated potassium channel subunit Kv1.6) (HBK2).

KCNA5_MOUSE
NC score	0.081410 (rank : 72)	θ value	θ > 10 (rank : 125)
Query Neighborhood Hits	118	Target Neighborhood Hits	119	Shared Neighborhood Hits	38
SwissProt Accessions	Q61762	Gene names	Kcna5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (KV1-5).

KCNA3_HUMAN
NC score	0.079699 (rank : 73)	θ value	θ > 10 (rank : 120)
Query Neighborhood Hits	118	Target Neighborhood Hits	101	Shared Neighborhood Hits	37
SwissProt Accessions	P22001	Gene names	KCNA3, HGK5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (HPCN3) (HGK5) (HuKIII) (HLK3).

KCNG4_HUMAN
NC score	0.078898 (rank : 74)	θ value	θ > 10 (rank : 129)
Query Neighborhood Hits	118	Target Neighborhood Hits	99	Shared Neighborhood Hits	30
SwissProt Accessions	Q8TDN1, Q96H24	Gene names	KCNG4, KCNG3
Domain Architecture
Description	Potassium voltage-gated channel subfamily G member 4 (Voltage-gated potassium channel subunit Kv6.4).

KCNA3_MOUSE
NC score	0.078796 (rank : 75)	θ value	θ > 10 (rank : 121)
Query Neighborhood Hits	118	Target Neighborhood Hits	103	Shared Neighborhood Hits	35
SwissProt Accessions	P16390	Gene names	Kcna3
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 3 (Voltage-gated potassium channel subunit Kv1.3) (MK3).

KCNQ1_MOUSE
NC score	0.076542 (rank : 76)	θ value	θ > 10 (rank : 131)
Query Neighborhood Hits	118	Target Neighborhood Hits	175	Shared Neighborhood Hits	41
SwissProt Accessions	P97414, O88702, Q7TNZ1, Q7TPL7, Q80VR7	Gene names	Kcnq1, Kcna9, Kvlqt1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

KCNA5_HUMAN
NC score	0.076481 (rank : 77)	θ value	θ > 10 (rank : 124)
Query Neighborhood Hits	118	Target Neighborhood Hits	124	Shared Neighborhood Hits	34
SwissProt Accessions	P22460	Gene names	KCNA5
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 5 (Voltage-gated potassium channel subunit Kv1.5) (HK2) (HPCN1).

KCNA4_MOUSE
NC score	0.069629 (rank : 78)	θ value	θ > 10 (rank : 123)
Query Neighborhood Hits	118	Target Neighborhood Hits	98	Shared Neighborhood Hits	32
SwissProt Accessions	Q61423	Gene names	Kcna4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4).

KCNA4_HUMAN
NC score	0.069408 (rank : 79)	θ value	θ > 10 (rank : 122)
Query Neighborhood Hits	118	Target Neighborhood Hits	108	Shared Neighborhood Hits	32
SwissProt Accessions	P22459	Gene names	KCNA4
Domain Architecture
Description	Potassium voltage-gated channel subfamily A member 4 (Voltage-gated potassium channel subunit Kv1.4) (HK1) (HPCN2) (HBK4) (HUKII).

PKDRE_MOUSE
NC score	0.068896 (rank : 80)	θ value	θ > 10 (rank : 140)
Query Neighborhood Hits	118	Target Neighborhood Hits	76	Shared Neighborhood Hits	20
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

KCNQ1_HUMAN
NC score	0.063882 (rank : 81)	θ value	θ > 10 (rank : 130)
Query Neighborhood Hits	118	Target Neighborhood Hits	99	Shared Neighborhood Hits	35
SwissProt Accessions	P51787, O00347, O60607, O94787, Q7Z6G9, Q92960, Q9UMN8, Q9UMN9	Gene names	KCNQ1, KCNA8, KCNA9, KVLQT1
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 1 (Voltage-gated potassium channel subunit Kv7.1) (IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1) (KQT-like 1).

KCNQ5_HUMAN
NC score	0.063403 (rank : 82)	θ value	θ > 10 (rank : 137)
Query Neighborhood Hits	118	Target Neighborhood Hits	163	Shared Neighborhood Hits	37
SwissProt Accessions	Q9NR82, Q9NRN0, Q9NYA6	Gene names	KCNQ5
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 5 (Voltage-gated potassium channel subunit Kv7.5) (Potassium channel subunit alpha KvLQT5) (KQT-like 5).

DJBP_MOUSE
NC score	0.062902 (rank : 83)	θ value	0.0148317 (rank : 48)
Query Neighborhood Hits	118	Target Neighborhood Hits	152	Shared Neighborhood Hits	13
SwissProt Accessions	Q6P1E8, Q5DTV8, Q6PGK8, Q9D2D8	Gene names	Djbp, Kiaa1672
Domain Architecture	No domain graphic available
Description	DJ-1-binding protein.

MCLN2_MOUSE
NC score	0.060758 (rank : 84)	θ value	θ > 10 (rank : 138)
Query Neighborhood Hits	118	Target Neighborhood Hits	31	Shared Neighborhood Hits	17
SwissProt Accessions	Q8K595, Q3UCG4, Q8K2T6, Q9CQD3	Gene names	Mcoln2
Domain Architecture	No domain graphic available
Description	Mucolipin-2.

KCNQ2_HUMAN
NC score	0.059596 (rank : 85)	θ value	θ > 10 (rank : 132)
Query Neighborhood Hits	118	Target Neighborhood Hits	114	Shared Neighborhood Hits	33
SwissProt Accessions	O43526, O43796, O75580, O95845, Q5VYT8, Q96J59, Q99454	Gene names	KCNQ2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Neuroblastoma-specific potassium channel subunit alpha KvLQT2) (KQT-like 2).

TRPV3_HUMAN
NC score	0.056284 (rank : 86)	θ value	1.81305 (rank : 71)
Query Neighborhood Hits	118	Target Neighborhood Hits	198	Shared Neighborhood Hits	26
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

KCNQ2_MOUSE
NC score	0.055860 (rank : 87)	θ value	θ > 10 (rank : 133)
Query Neighborhood Hits	118	Target Neighborhood Hits	163	Shared Neighborhood Hits	33
SwissProt Accessions	Q9Z351, Q8R498, Q9QWN9, Q9Z342, Q9Z343, Q9Z344, Q9Z345, Q9Z346, Q9Z347, Q9Z348, Q9Z349, Q9Z350	Gene names	Kcnq2, Kqt2
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 2 (Voltage-gated potassium channel subunit Kv7.2) (Potassium channel subunit alpha KvLQT2) (KQT-like 2).

KCNQ3_HUMAN
NC score	0.054097 (rank : 88)	θ value	θ > 10 (rank : 134)
Query Neighborhood Hits	118	Target Neighborhood Hits	114	Shared Neighborhood Hits	36
SwissProt Accessions	O43525	Gene names	KCNQ3
Domain Architecture
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

KCNQ3_MOUSE
NC score	0.053083 (rank : 89)	θ value	θ > 10 (rank : 135)
Query Neighborhood Hits	118	Target Neighborhood Hits	105	Shared Neighborhood Hits	36
SwissProt Accessions	Q8K3F6	Gene names	Kcnq3
Domain Architecture	No domain graphic available
Description	Potassium voltage-gated channel subfamily KQT member 3 (Voltage-gated potassium channel subunit Kv7.3) (Potassium channel subunit alpha KvLQT3) (KQT-like 3).

TRPV3_MOUSE
NC score	0.036707 (rank : 90)	θ value	8.99809 (rank : 118)
Query Neighborhood Hits	118	Target Neighborhood Hits	188	Shared Neighborhood Hits	22
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

MCLN3_MOUSE
NC score	0.034806 (rank : 91)	θ value	5.27518 (rank : 95)
Query Neighborhood Hits	118	Target Neighborhood Hits	29	Shared Neighborhood Hits	14
SwissProt Accessions	Q8R4F0, Q8BS73, Q8BSG1, Q8CDB2	Gene names	Mcoln3
Domain Architecture	No domain graphic available
Description	Mucolipin-3.

GPTC8_HUMAN
NC score	0.034247 (rank : 92)	θ value	0.0736092 (rank : 49)
Query Neighborhood Hits	118	Target Neighborhood Hits	366	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UKJ3, O60300	Gene names	GPATC8, KIAA0553
Domain Architecture	No domain graphic available
Description	G patch domain-containing protein 8.

DNL3_HUMAN
NC score	0.028453 (rank : 93)	θ value	5.27518 (rank : 94)
Query Neighborhood Hits	118	Target Neighborhood Hits	49	Shared Neighborhood Hits	8
SwissProt Accessions	P49916, Q16714	Gene names	LIG3
Domain Architecture
Description	DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3).

DNL3_MOUSE
NC score	0.025251 (rank : 94)	θ value	6.88961 (rank : 103)
Query Neighborhood Hits	118	Target Neighborhood Hits	37	Shared Neighborhood Hits	7
SwissProt Accessions	P97386, P97385	Gene names	Lig3
Domain Architecture
Description	DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3).

TARA_HUMAN
NC score	0.022785 (rank : 95)	θ value	0.813845 (rank : 60)
Query Neighborhood Hits	118	Target Neighborhood Hits	1626	Shared Neighborhood Hits	29
SwissProt Accessions	Q9H2D6, O94797, Q2PZW8, Q2Q3Z9, Q2Q400, Q5R3M6, Q96DW1, Q9BT77, Q9BTL7, Q9BY98, Q9Y3L4	Gene names	TRIOBP, KIAA1662, TARA
Domain Architecture
Description	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin).

TP53B_HUMAN
NC score	0.016637 (rank : 96)	θ value	1.81305 (rank : 70)
Query Neighborhood Hits	118	Target Neighborhood Hits	413	Shared Neighborhood Hits	13
SwissProt Accessions	Q12888, Q2M1Z7, Q4LE46, Q5FWZ3, Q7Z3U4	Gene names	TP53BP1
Domain Architecture
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

BAT2_HUMAN
NC score	0.016123 (rank : 97)	θ value	6.88961 (rank : 102)
Query Neighborhood Hits	118	Target Neighborhood Hits	931	Shared Neighborhood Hits	18
SwissProt Accessions	P48634, O95875, Q5SQ29, Q5SQ30, Q5ST84, Q5STX6, Q5STX7, Q68DW9, Q6P9P7, Q6PIN1, Q96QC6	Gene names	BAT2, G2
Domain Architecture
Description	Large proline-rich protein BAT2 (HLA-B-associated transcript 2).

DPOLZ_HUMAN
NC score	0.014932 (rank : 98)	θ value	0.279714 (rank : 54)
Query Neighborhood Hits	118	Target Neighborhood Hits	200	Shared Neighborhood Hits	4
SwissProt Accessions	O60673, O43214	Gene names	REV3L, POLZ, REV3
Domain Architecture
Description	DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (hREV3).

MLL2_HUMAN
NC score	0.014845 (rank : 99)	θ value	0.365318 (rank : 59)
Query Neighborhood Hits	118	Target Neighborhood Hits	1788	Shared Neighborhood Hits	27
SwissProt Accessions	O14686, O14687	Gene names	MLL2, ALR
Domain Architecture
Description	Myeloid/lymphoid or mixed-lineage leukemia protein 2 (ALL1-related protein).

LIF_MOUSE
NC score	0.012841 (rank : 100)	θ value	3.0926 (rank : 80)
Query Neighborhood Hits	118	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	P09056	Gene names	Lif
Domain Architecture
Description	Leukemia inhibitory factor precursor (LIF) (Differentiation- stimulating factor) (D factor).

NSBP1_MOUSE
NC score	0.010883 (rank : 101)	θ value	3.0926 (rank : 81)
Query Neighborhood Hits	118	Target Neighborhood Hits	681	Shared Neighborhood Hits	13
SwissProt Accessions	Q9JL35, O88832, Q8VC71, Q9CUW1	Gene names	Nsbp1, Garp45
Domain Architecture	No domain graphic available
Description	Nucleosome-binding protein 1 (Nucleosome-binding protein 45) (NBP-45) (GARP45 protein).

PHAR3_HUMAN
NC score	0.010847 (rank : 102)	θ value	4.03905 (rank : 90)
Query Neighborhood Hits	118	Target Neighborhood Hits	169	Shared Neighborhood Hits	8
SwissProt Accessions	Q96KR7, Q707P6, Q9H4T4	Gene names	PHACTR3, C20orf101, SCAPIN1
Domain Architecture	No domain graphic available
Description	Phosphatase and actin regulator 3 (Scapinin) (Scaffold-associated PP1- inhibiting protein).

DOCK4_MOUSE
NC score	0.010487 (rank : 103)	θ value	1.81305 (rank : 67)
Query Neighborhood Hits	118	Target Neighborhood Hits	210	Shared Neighborhood Hits	9
SwissProt Accessions	P59764	Gene names	Dock4, Kiaa0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

RPTN_MOUSE
NC score	0.010340 (rank : 104)	θ value	5.27518 (rank : 100)
Query Neighborhood Hits	118	Target Neighborhood Hits	650	Shared Neighborhood Hits	17
SwissProt Accessions	P97347	Gene names	Rptn
Domain Architecture
Description	Repetin.

EPC2_HUMAN
NC score	0.009594 (rank : 105)	θ value	1.38821 (rank : 62)
Query Neighborhood Hits	118	Target Neighborhood Hits	58	Shared Neighborhood Hits	2
SwissProt Accessions	Q52LR7, Q7L9J1, Q96RR7, Q9NUT8, Q9NVR1, Q9UFM9	Gene names	EPC2
Domain Architecture	No domain graphic available
Description	Enhancer of polycomb homolog 2.

DOCK4_HUMAN
NC score	0.009492 (rank : 106)	θ value	1.81305 (rank : 66)
Query Neighborhood Hits	118	Target Neighborhood Hits	237	Shared Neighborhood Hits	9
SwissProt Accessions	Q8N1I0, O14584, O94824, Q8NB45	Gene names	DOCK4, KIAA0716
Domain Architecture
Description	Dedicator of cytokinesis protein 4.

LEO1_MOUSE
NC score	0.009201 (rank : 107)	θ value	1.38821 (rank : 64)
Query Neighborhood Hits	118	Target Neighborhood Hits	946	Shared Neighborhood Hits	15
SwissProt Accessions	Q5XJE5, Q640R1	Gene names	Leo1
Domain Architecture	No domain graphic available
Description	RNA polymerase-associated protein LEO1.

PPA5_HUMAN
NC score	0.008547 (rank : 108)	θ value	5.27518 (rank : 99)
Query Neighborhood Hits	118	Target Neighborhood Hits	5	Shared Neighborhood Hits	2
SwissProt Accessions	P13686, Q6IAS6	Gene names	ACP5
Domain Architecture
Description	Tartrate-resistant acid phosphatase type 5 precursor (EC 3.1.3.2) (TR- AP) (Tartrate-resistant acid ATPase) (TrATPase) (Acid phosphatase 5, tartrate resistant).

CABL2_HUMAN
NC score	0.008432 (rank : 109)	θ value	2.36792 (rank : 72)
Query Neighborhood Hits	118	Target Neighborhood Hits	84	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BTV7, Q5JWL0, Q9BYK0	Gene names	CABLES2, C20orf150
Domain Architecture
Description	CDK5 and ABL1 enzyme substrate 2 (Interactor with CDK3 2) (Ik3-2).

PHAR3_MOUSE
NC score	0.007789 (rank : 110)	θ value	5.27518 (rank : 98)
Query Neighborhood Hits	118	Target Neighborhood Hits	206	Shared Neighborhood Hits	7
SwissProt Accessions	Q8BYK5, Q8BYS8, Q8C058, Q9DB87	Gene names	Phactr3, Scapin1
Domain Architecture	No domain graphic available
Description	Phosphatase and actin regulator 3 (Scapinin) (Scaffold-associated PP1- inhibiting protein).

RPB1_HUMAN
NC score	0.006980 (rank : 111)	θ value	4.03905 (rank : 91)
Query Neighborhood Hits	118	Target Neighborhood Hits	362	Shared Neighborhood Hits	9
SwissProt Accessions	P24928	Gene names	POLR2A
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

RPB1_MOUSE
NC score	0.006973 (rank : 112)	θ value	4.03905 (rank : 92)
Query Neighborhood Hits	118	Target Neighborhood Hits	363	Shared Neighborhood Hits	9
SwissProt Accessions	P08775	Gene names	Polr2a, Rpii215, Rpo2-1
Domain Architecture
Description	DNA-directed RNA polymerase II largest subunit (EC 2.7.7.6) (RPB1).

SRCH_HUMAN
NC score	0.006879 (rank : 113)	θ value	8.99809 (rank : 115)
Query Neighborhood Hits	118	Target Neighborhood Hits	225	Shared Neighborhood Hits	7
SwissProt Accessions	P23327, Q504Y6	Gene names	HRC, HCP
Domain Architecture	No domain graphic available
Description	Sarcoplasmic reticulum histidine-rich calcium-binding protein precursor.

FRS3_MOUSE
NC score	0.006550 (rank : 114)	θ value	4.03905 (rank : 86)
Query Neighborhood Hits	118	Target Neighborhood Hits	168	Shared Neighborhood Hits	5
SwissProt Accessions	Q91WJ0	Gene names	Frs3, Frs2b
Domain Architecture	No domain graphic available
Description	Fibroblast growth factor receptor substrate 3 (FGFR substrate 3) (FRS2-beta).

CENPU_HUMAN
NC score	0.006478 (rank : 115)	θ value	4.03905 (rank : 85)
Query Neighborhood Hits	118	Target Neighborhood Hits	289	Shared Neighborhood Hits	4
SwissProt Accessions	Q71F23, Q32Q71, Q9H5G1	Gene names	MLF1IP, CENPU, ICEN24, KLIP1
Domain Architecture	No domain graphic available
Description	Centromere protein U (CENP-U) (CENP-U(50)) (CENP-50) (Interphase centromere complex protein 24) (MLF1-interacting protein) (KSHV latent nuclear antigen-interacting protein 1).

CABP4_HUMAN
NC score	0.006185 (rank : 116)	θ value	8.99809 (rank : 108)
Query Neighborhood Hits	118	Target Neighborhood Hits	250	Shared Neighborhood Hits	5
SwissProt Accessions	P57796, Q8N4Z2, Q8WWY5	Gene names	CABP4
Domain Architecture
Description	Calcium-binding protein 4 (CaBP4).

AGGF1_HUMAN
NC score	0.005966 (rank : 117)	θ value	4.03905 (rank : 84)
Query Neighborhood Hits	118	Target Neighborhood Hits	271	Shared Neighborhood Hits	4
SwissProt Accessions	Q8N302, O00581, Q53YS3, Q9BU84, Q9NW66	Gene names	AGGF1, VG5Q
Domain Architecture
Description	Angiogenic factor with G patch and FHA domains 1 (Angiogenic factor VG5Q) (Vasculogenesis gene on 5q protein) (hVG5Q).

PAD5_MOUSE
NC score	0.005687 (rank : 118)	θ value	5.27518 (rank : 97)
Query Neighborhood Hits	118	Target Neighborhood Hits	32	Shared Neighborhood Hits	3
SwissProt Accessions	Q68ED3, Q8C0K6	Gene names	Papd5
Domain Architecture	No domain graphic available
Description	PAP-associated domain-containing protein 5 (EC 2.7.7.-) (Topoisomerase-related function protein 4-2) (TRF4-2).

S61A2_HUMAN
NC score	0.005162 (rank : 119)	θ value	8.99809 (rank : 113)
Query Neighborhood Hits	118	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q9H9S3	Gene names	SEC61A2
Domain Architecture
Description	Protein transport protein Sec61 subunit alpha isoform 2 (Sec61 alpha- 2).

S61A2_MOUSE
NC score	0.005162 (rank : 120)	θ value	8.99809 (rank : 114)
Query Neighborhood Hits	118	Target Neighborhood Hits	11	Shared Neighborhood Hits	3
SwissProt Accessions	Q9JLR1	Gene names	Sec61a2
Domain Architecture
Description	Protein transport protein Sec61 subunit alpha isoform 2 (Sec61 alpha- 2).

WBS14_MOUSE
NC score	0.004997 (rank : 121)	θ value	6.88961 (rank : 106)
Query Neighborhood Hits	118	Target Neighborhood Hits	171	Shared Neighborhood Hits	8
SwissProt Accessions	Q99MZ3, Q99MY9, Q99MZ0, Q99MZ1, Q99MZ2, Q9JLM5	Gene names	Mlxipl, Mio, Wbscr14
Domain Architecture
Description	Williams-Beuren syndrome chromosome region 14 protein homolog (Mlx interactor) (MLX-interacting protein-like).

RPGR_MOUSE
NC score	0.004901 (rank : 122)	θ value	3.0926 (rank : 82)
Query Neighborhood Hits	118	Target Neighborhood Hits	281	Shared Neighborhood Hits	6
SwissProt Accessions	Q9R0X5, O88408, Q9CU92	Gene names	Rpgr
Domain Architecture
Description	X-linked retinitis pigmentosa GTPase regulator (mRpgr).

TMC2_HUMAN
NC score	0.004701 (rank : 123)	θ value	8.99809 (rank : 117)
Query Neighborhood Hits	118	Target Neighborhood Hits	149	Shared Neighborhood Hits	6
SwissProt Accessions	Q8TDI7, Q5JXT0, Q5JXT1, Q6UWW4, Q6ZS41, Q8N9F3, Q9BYN2, Q9BYN3, Q9BYN4, Q9BYN5	Gene names	TMC2
Domain Architecture	No domain graphic available
Description	Transmembrane cochlear-expressed protein 2.

MINT_HUMAN
NC score	0.004622 (rank : 124)	θ value	4.03905 (rank : 88)
Query Neighborhood Hits	118	Target Neighborhood Hits	1291	Shared Neighborhood Hits	23
SwissProt Accessions	Q96T58, Q9H9A8, Q9NWH5, Q9UQ01, Q9Y556	Gene names	SPEN, KIAA0929, MINT, SHARP
Domain Architecture
Description	Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein).

ARHGC_MOUSE
NC score	0.004172 (rank : 125)	θ value	1.38821 (rank : 61)
Query Neighborhood Hits	118	Target Neighborhood Hits	344	Shared Neighborhood Hits	3
SwissProt Accessions	Q8R4H2, Q80U18	Gene names	Arhgef12, Kiaa0382, Larg
Domain Architecture
Description	Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF).

GEMI5_HUMAN
NC score	0.003725 (rank : 126)	θ value	2.36792 (rank : 74)
Query Neighborhood Hits	118	Target Neighborhood Hits	362	Shared Neighborhood Hits	3
SwissProt Accessions	Q8TEQ6, Q8WWV4, Q969W4, Q9H9K3, Q9UFI5	Gene names	GEMIN5
Domain Architecture
Description	Gem-associated protein 5 (Gemin5).

E41LB_HUMAN
NC score	0.003646 (rank : 127)	θ value	2.36792 (rank : 73)
Query Neighborhood Hits	118	Target Neighborhood Hits	79	Shared Neighborhood Hits	4
SwissProt Accessions	Q9H329, Q9H328, Q9P2V3	Gene names	EPB41L4B, EHM2
Domain Architecture
Description	Band 4.1-like protein 4B (Protein EHM2) (FERM-containing protein CG1).

CD53_MOUSE
NC score	0.003600 (rank : 128)	θ value	3.0926 (rank : 76)
Query Neighborhood Hits	118	Target Neighborhood Hits	52	Shared Neighborhood Hits	2
SwissProt Accessions	Q61451, Q61721	Gene names	Cd53
Domain Architecture
Description	Leukocyte surface antigen CD53 (Cell surface glycoprotein CD53).

TACC2_MOUSE
NC score	0.002851 (rank : 129)	θ value	3.0926 (rank : 83)
Query Neighborhood Hits	118	Target Neighborhood Hits	774	Shared Neighborhood Hits	15
SwissProt Accessions	Q9JJG0	Gene names	Tacc2
Domain Architecture
Description	Transforming acidic coiled-coil-containing protein 2.

ARI5B_HUMAN
NC score	0.002719 (rank : 130)	θ value	8.99809 (rank : 107)
Query Neighborhood Hits	118	Target Neighborhood Hits	328	Shared Neighborhood Hits	5
SwissProt Accessions	Q14865, Q7Z3M4, Q8N421, Q9H786	Gene names	ARID5B, DESRT, MRF2
Domain Architecture
Description	AT-rich interactive domain-containing protein 5B (ARID domain- containing protein 5B) (Mrf1-like) (Modulator recognition factor 2) (MRF-2).

EP400_MOUSE
NC score	0.002033 (rank : 131)	θ value	8.99809 (rank : 110)
Query Neighborhood Hits	118	Target Neighborhood Hits	592	Shared Neighborhood Hits	10
SwissProt Accessions	Q8CHI8, Q80TC8, Q8BXI5, Q8BYW3, Q8C0P6, Q8CHI7, Q8VDF4, Q9DA54	Gene names	Ep400, Kiaa1498
Domain Architecture	No domain graphic available
Description	E1A-binding protein p400 (EC 3.6.1.-) (p400 kDa SWI2/SNF2-related protein) (Domino homolog) (mDomino).

CCDC6_HUMAN
NC score	0.002027 (rank : 132)	θ value	3.0926 (rank : 75)
Query Neighborhood Hits	118	Target Neighborhood Hits	723	Shared Neighborhood Hits	8
SwissProt Accessions	Q16204, Q15250	Gene names	CCDC6, D10S170
Domain Architecture
Description	Coiled-coil domain-containing protein 6 (H4 protein) (Papillary thyroid carcinoma-encoded protein).

SV2C_HUMAN
NC score	0.001875 (rank : 133)	θ value	8.99809 (rank : 116)
Query Neighborhood Hits	118	Target Neighborhood Hits	124	Shared Neighborhood Hits	5
SwissProt Accessions	Q496J9, Q496K1, Q9UPU8	Gene names	SV2C, KIAA1054
Domain Architecture	No domain graphic available
Description	Synaptic vesicle glycoprotein 2C.

FGD6_MOUSE
NC score	0.000898 (rank : 134)	θ value	6.88961 (rank : 104)
Query Neighborhood Hits	118	Target Neighborhood Hits	282	Shared Neighborhood Hits	5
SwissProt Accessions	Q69ZL1, Q8C8W5, Q8K3B0, Q9D3Y7	Gene names	Fgd6, Kiaa1362
Domain Architecture	No domain graphic available
Description	FYVE, RhoGEF and PH domain-containing protein 6.

ANR38_HUMAN
NC score	0.000845 (rank : 135)	θ value	6.88961 (rank : 101)
Query Neighborhood Hits	118	Target Neighborhood Hits	443	Shared Neighborhood Hits	9
SwissProt Accessions	Q5T7N3, Q6P9A0, Q86T71, Q86VE6, Q8NAX3	Gene names	ANKRD38
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 38.

SEM5A_MOUSE
NC score	0.000462 (rank : 136)	θ value	4.03905 (rank : 93)
Query Neighborhood Hits	118	Target Neighborhood Hits	162	Shared Neighborhood Hits	2
SwissProt Accessions	Q62217	Gene names	Sema5a, Semaf, SemF
Domain Architecture
Description	Semaphorin-5A precursor (Semaphorin F) (Sema F).

PLMN_MOUSE
NC score	0.000123 (rank : 137)	θ value	1.38821 (rank : 65)
Query Neighborhood Hits	118	Target Neighborhood Hits	208	Shared Neighborhood Hits	2
SwissProt Accessions	P20918, Q8CIS2, Q91WJ5	Gene names	Plg
Domain Architecture
Description	Plasminogen precursor (EC 3.4.21.7) [Contains: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B].

KI21A_MOUSE
NC score	-0.001204 (rank : 138)	θ value	8.99809 (rank : 112)
Query Neighborhood Hits	118	Target Neighborhood Hits	1317	Shared Neighborhood Hits	17
SwissProt Accessions	Q9QXL2, Q6P5H1, Q6ZPJ8, Q8BWZ9, Q8BXF1	Gene names	Kif21a, Kiaa1708
Domain Architecture	No domain graphic available
Description	Kinesin family member 21A.

NOTC1_MOUSE
NC score	-0.002943 (rank : 139)	θ value	5.27518 (rank : 96)
Query Neighborhood Hits	118	Target Neighborhood Hits	916	Shared Neighborhood Hits	8
SwissProt Accessions	Q01705, Q06007, Q61905, Q99JC2, Q9QW58, Q9R0X7	Gene names	Notch1, Motch
Domain Architecture
Description	Neurogenic locus notch homolog protein 1 precursor (Notch 1) (Motch A) (mT14) (p300) [Contains: Notch 1 extracellular truncation; Notch 1 intracellular domain].

PGFRA_MOUSE
NC score	-0.003543 (rank : 140)	θ value	4.03905 (rank : 89)
Query Neighborhood Hits	118	Target Neighborhood Hits	975	Shared Neighborhood Hits	3
SwissProt Accessions	P26618, Q62046	Gene names	Pdgfra
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).

CP135_MOUSE
NC score	-0.003750 (rank : 141)	θ value	8.99809 (rank : 109)
Query Neighborhood Hits	118	Target Neighborhood Hits	1278	Shared Neighborhood Hits	10
SwissProt Accessions	Q6P5D4, Q6A030	Gene names	Cep135, Cep4, Kiaa0635
Domain Architecture	No domain graphic available
Description	Centrosomal protein of 135 kDa (Cep135 protein) (Centrosomal protein 4).

PGFRA_HUMAN
NC score	-0.003833 (rank : 142)	θ value	6.88961 (rank : 105)
Query Neighborhood Hits	118	Target Neighborhood Hits	980	Shared Neighborhood Hits	3
SwissProt Accessions	P16234, Q96KZ7	Gene names	PDGFRA
Domain Architecture
Description	Alpha platelet-derived growth factor receptor precursor (EC 2.7.10.1) (PDGF-R-alpha) (CD140a antigen).