Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : PK2L2_MOUSE

For an explanation of this page, click here

PK2L2_MOUSE
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PK2L2_HUMAN
θ value	0 (rank : 1)	NC score	0.989577 (rank : 2)
Query Neighborhood Hits	84	Target Neighborhood Hits	90	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PK2L2_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	84	Target Neighborhood Hits	84	Shared Neighborhood Hits	84
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PKD2_HUMAN
θ value	2.78268e-134 (rank : 3)	NC score	0.961251 (rank : 4)
Query Neighborhood Hits	84	Target Neighborhood Hits	105	Shared Neighborhood Hits	64
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

PK2L1_HUMAN
θ value	3.4016e-132 (rank : 4)	NC score	0.963751 (rank : 3)
Query Neighborhood Hits	84	Target Neighborhood Hits	132	Shared Neighborhood Hits	67
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

PKD2_MOUSE
θ value	7.09276e-130 (rank : 5)	NC score	0.960207 (rank : 5)
Query Neighborhood Hits	84	Target Neighborhood Hits	99	Shared Neighborhood Hits	62
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

PKDRE_HUMAN
θ value	9.24701e-21 (rank : 6)	NC score	0.604381 (rank : 6)
Query Neighborhood Hits	84	Target Neighborhood Hits	64	Shared Neighborhood Hits	34
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

PKDRE_MOUSE
θ value	9.24701e-21 (rank : 7)	NC score	0.577463 (rank : 7)
Query Neighborhood Hits	84	Target Neighborhood Hits	76	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

PK1L1_HUMAN
θ value	3.40345e-15 (rank : 8)	NC score	0.493587 (rank : 8)
Query Neighborhood Hits	84	Target Neighborhood Hits	140	Shared Neighborhood Hits	13
SwissProt Accessions	Q8TDX9, Q6UWK1	Gene names	PKD1L1
Domain Architecture
Description	Polycystic kidney disease 1-like 1 protein (Polycystin-1L1).

PKD1_HUMAN
θ value	7.84624e-12 (rank : 9)	NC score	0.301707 (rank : 29)
Query Neighborhood Hits	84	Target Neighborhood Hits	387	Shared Neighborhood Hits	9
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

MCLN2_MOUSE
θ value	1.9326e-10 (rank : 10)	NC score	0.427578 (rank : 9)
Query Neighborhood Hits	84	Target Neighborhood Hits	31	Shared Neighborhood Hits	25
SwissProt Accessions	Q8K595, Q3UCG4, Q8K2T6, Q9CQD3	Gene names	Mcoln2
Domain Architecture	No domain graphic available
Description	Mucolipin-2.

MCLN3_HUMAN
θ value	2.52405e-10 (rank : 11)	NC score	0.414704 (rank : 11)
Query Neighborhood Hits	84	Target Neighborhood Hits	26	Shared Neighborhood Hits	23
SwissProt Accessions	Q8TDD5, Q5T4H5, Q5T4H6, Q9NV09	Gene names	MCOLN3
Domain Architecture	No domain graphic available
Description	Mucolipin-3.

MCLN3_MOUSE
θ value	3.29651e-10 (rank : 12)	NC score	0.412204 (rank : 12)
Query Neighborhood Hits	84	Target Neighborhood Hits	29	Shared Neighborhood Hits	24
SwissProt Accessions	Q8R4F0, Q8BS73, Q8BSG1, Q8CDB2	Gene names	Mcoln3
Domain Architecture	No domain graphic available
Description	Mucolipin-3.

MCLN2_HUMAN
θ value	3.64472e-09 (rank : 13)	NC score	0.418132 (rank : 10)
Query Neighborhood Hits	84	Target Neighborhood Hits	23	Shared Neighborhood Hits	22
SwissProt Accessions	Q8IZK6, Q8N9R3	Gene names	MCOLN2
Domain Architecture	No domain graphic available
Description	Mucolipin-2.

CAC1F_MOUSE
θ value	1.17247e-07 (rank : 14)	NC score	0.359244 (rank : 15)
Query Neighborhood Hits	84	Target Neighborhood Hits	142	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1C_HUMAN
θ value	1.53129e-07 (rank : 15)	NC score	0.353315 (rank : 18)
Query Neighborhood Hits	84	Target Neighborhood Hits	158	Shared Neighborhood Hits	36
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

CAC1D_HUMAN
θ value	1.53129e-07 (rank : 16)	NC score	0.347207 (rank : 21)
Query Neighborhood Hits	84	Target Neighborhood Hits	118	Shared Neighborhood Hits	37
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

CAC1C_MOUSE
θ value	1.99992e-07 (rank : 17)	NC score	0.354284 (rank : 17)
Query Neighborhood Hits	84	Target Neighborhood Hits	130	Shared Neighborhood Hits	35
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

CAC1F_HUMAN
θ value	5.81887e-07 (rank : 18)	NC score	0.355427 (rank : 16)
Query Neighborhood Hits	84	Target Neighborhood Hits	141	Shared Neighborhood Hits	34
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

MCLN1_HUMAN
θ value	9.92553e-07 (rank : 19)	NC score	0.379211 (rank : 13)
Query Neighborhood Hits	84	Target Neighborhood Hits	26	Shared Neighborhood Hits	16
SwissProt Accessions	Q9GZU1, Q7Z4F7, Q9H292, Q9H4B3, Q9H4B5	Gene names	MCOLN1, ML4
Domain Architecture	No domain graphic available
Description	Mucolipin-1 (Mucolipidin) (MG-2).

CAC1E_HUMAN
θ value	1.29631e-06 (rank : 20)	NC score	0.348640 (rank : 20)
Query Neighborhood Hits	84	Target Neighborhood Hits	148	Shared Neighborhood Hits	39
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

MCLN1_MOUSE
θ value	1.29631e-06 (rank : 21)	NC score	0.374417 (rank : 14)
Query Neighborhood Hits	84	Target Neighborhood Hits	24	Shared Neighborhood Hits	17
SwissProt Accessions	Q99J21	Gene names	Mcoln1
Domain Architecture	No domain graphic available
Description	Mucolipin-1 (Mucolipidin).

CAC1E_MOUSE
θ value	4.92598e-06 (rank : 22)	NC score	0.349167 (rank : 19)
Query Neighborhood Hits	84	Target Neighborhood Hits	167	Shared Neighborhood Hits	39
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

TRPA1_HUMAN
θ value	8.40245e-06 (rank : 23)	NC score	0.119832 (rank : 62)
Query Neighborhood Hits	84	Target Neighborhood Hits	339	Shared Neighborhood Hits	26
SwissProt Accessions	O75762	Gene names	TRPA1, ANKTM1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation sensitive-protein p120).

CAC1B_HUMAN
θ value	7.1131e-05 (rank : 24)	NC score	0.344137 (rank : 22)
Query Neighborhood Hits	84	Target Neighborhood Hits	257	Shared Neighborhood Hits	45
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

TRPC3_MOUSE
θ value	9.29e-05 (rank : 25)	NC score	0.227108 (rank : 46)
Query Neighborhood Hits	84	Target Neighborhood Hits	131	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QZC1, Q61058	Gene names	Trpc3, Trp3, Trrp3
Domain Architecture
Description	Short transient receptor potential channel 3 (TrpC3) (Transient receptor protein 3) (Mtrp3) (Receptor-activated cation channel TRP3) (trp-related protein 3).

TRPC6_HUMAN
θ value	9.29e-05 (rank : 26)	NC score	0.208433 (rank : 49)
Query Neighborhood Hits	84	Target Neighborhood Hits	171	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y210, Q9HCW3, Q9NQA8, Q9NQA9	Gene names	TRPC6, TRP6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6).

TRPC6_MOUSE
θ value	9.29e-05 (rank : 27)	NC score	0.209137 (rank : 48)
Query Neighborhood Hits	84	Target Neighborhood Hits	171	Shared Neighborhood Hits	26
SwissProt Accessions	Q61143, Q9Z2J1	Gene names	Trpc6, Trp6, Trrp6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6) (Calcium entry channel).

TRPC3_HUMAN
θ value	0.000121331 (rank : 28)	NC score	0.225848 (rank : 47)
Query Neighborhood Hits	84	Target Neighborhood Hits	137	Shared Neighborhood Hits	26
SwissProt Accessions	Q13507, O00593, Q15660	Gene names	TRPC3, TRP3
Domain Architecture
Description	Short transient receptor potential channel 3 (TrpC3) (Htrp-3) (Htrp3).

TRPA1_MOUSE
θ value	0.000158464 (rank : 29)	NC score	0.112636 (rank : 67)
Query Neighborhood Hits	84	Target Neighborhood Hits	343	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BLA8	Gene names	Trpa1, Anktm1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1).

CAC1S_HUMAN
θ value	0.000270298 (rank : 30)	NC score	0.337598 (rank : 23)
Query Neighborhood Hits	84	Target Neighborhood Hits	92	Shared Neighborhood Hits	35
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1B_MOUSE
θ value	0.000461057 (rank : 31)	NC score	0.334611 (rank : 25)
Query Neighborhood Hits	84	Target Neighborhood Hits	351	Shared Neighborhood Hits	43
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1S_MOUSE
θ value	0.000602161 (rank : 32)	NC score	0.335092 (rank : 24)
Query Neighborhood Hits	84	Target Neighborhood Hits	98	Shared Neighborhood Hits	34
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

SCN9A_HUMAN
θ value	0.000602161 (rank : 33)	NC score	0.274068 (rank : 33)
Query Neighborhood Hits	84	Target Neighborhood Hits	157	Shared Neighborhood Hits	40
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

SC11A_HUMAN
θ value	0.000786445 (rank : 34)	NC score	0.302213 (rank : 28)
Query Neighborhood Hits	84	Target Neighborhood Hits	111	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

TRPC7_HUMAN
θ value	0.000786445 (rank : 35)	NC score	0.193164 (rank : 53)
Query Neighborhood Hits	84	Target Neighborhood Hits	123	Shared Neighborhood Hits	26
SwissProt Accessions	Q9HCX4	Gene names	TRPC7, TRP7
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (TRP7 protein).

TRPC7_MOUSE
θ value	0.000786445 (rank : 36)	NC score	0.193294 (rank : 52)
Query Neighborhood Hits	84	Target Neighborhood Hits	114	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WVC5	Gene names	Trpc7, Trp7, Trrp8
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (mTRP7).

CAC1A_HUMAN
θ value	0.00134147 (rank : 37)	NC score	0.318708 (rank : 27)
Query Neighborhood Hits	84	Target Neighborhood Hits	387	Shared Neighborhood Hits	40
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1A_MOUSE
θ value	0.00134147 (rank : 38)	NC score	0.320941 (rank : 26)
Query Neighborhood Hits	84	Target Neighborhood Hits	267	Shared Neighborhood Hits	40
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

TRPM7_HUMAN
θ value	0.00228821 (rank : 39)	NC score	0.116111 (rank : 64)
Query Neighborhood Hits	84	Target Neighborhood Hits	104	Shared Neighborhood Hits	25
SwissProt Accessions	Q96QT4, Q6ZMF5, Q86VJ4, Q8NBW2, Q9BXB2, Q9NXQ2	Gene names	TRPM7, CHAK1, LTRPC7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Long transient receptor potential channel 7) (LTrpC7) (Channel-kinase 1).

SC10A_HUMAN
θ value	0.00665767 (rank : 40)	NC score	0.273964 (rank : 34)
Query Neighborhood Hits	84	Target Neighborhood Hits	116	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

TRPM7_MOUSE
θ value	0.00665767 (rank : 41)	NC score	0.118364 (rank : 63)
Query Neighborhood Hits	84	Target Neighborhood Hits	113	Shared Neighborhood Hits	27
SwissProt Accessions	Q923J1, Q8C7S7, Q8CE54, Q921Y5, Q925B2, Q9CUT2, Q9JLQ1	Gene names	Trpm7, Chak, Ltrpc7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Long transient receptor potential channel 7) (LTrpC7) (Channel-kinase 1) (Transient receptor potential-phospholipase C- interacting kinase) (TRP-PLIK).

CAC1I_HUMAN
θ value	0.00869519 (rank : 42)	NC score	0.294266 (rank : 30)
Query Neighborhood Hits	84	Target Neighborhood Hits	138	Shared Neighborhood Hits	35
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

SCN1A_HUMAN
θ value	0.0113563 (rank : 43)	NC score	0.269667 (rank : 36)
Query Neighborhood Hits	84	Target Neighborhood Hits	148	Shared Neighborhood Hits	42
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SCN2A_HUMAN
θ value	0.0113563 (rank : 44)	NC score	0.269346 (rank : 37)
Query Neighborhood Hits	84	Target Neighborhood Hits	157	Shared Neighborhood Hits	41
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

TRPC4_HUMAN
θ value	0.0113563 (rank : 45)	NC score	0.207212 (rank : 50)
Query Neighborhood Hits	84	Target Neighborhood Hits	140	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UBN4, Q15721, Q9UIB0, Q9UIB1, Q9UIB2	Gene names	TRPC4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (trp-related protein 4) (hTrp-4) (hTrp4).

TRPC4_MOUSE
θ value	0.0113563 (rank : 46)	NC score	0.206811 (rank : 51)
Query Neighborhood Hits	84	Target Neighborhood Hits	141	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QUQ5, Q62350, Q9QUQ9, Q9QZC0	Gene names	Trpc4, Trrp4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (Receptor- activated cation channel TRP4) (Capacitative calcium entry channel Trp4).

SCN4A_HUMAN
θ value	0.0148317 (rank : 47)	NC score	0.268555 (rank : 39)
Query Neighborhood Hits	84	Target Neighborhood Hits	133	Shared Neighborhood Hits	43
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

SC11A_MOUSE
θ value	0.0193708 (rank : 48)	NC score	0.279146 (rank : 32)
Query Neighborhood Hits	84	Target Neighborhood Hits	116	Shared Neighborhood Hits	46
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

SCN3A_HUMAN
θ value	0.0193708 (rank : 49)	NC score	0.268337 (rank : 40)
Query Neighborhood Hits	84	Target Neighborhood Hits	115	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

CAC1G_HUMAN
θ value	0.0431538 (rank : 50)	NC score	0.268766 (rank : 38)
Query Neighborhood Hits	84	Target Neighborhood Hits	587	Shared Neighborhood Hits	43
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

SC10A_MOUSE
θ value	0.0431538 (rank : 51)	NC score	0.273142 (rank : 35)
Query Neighborhood Hits	84	Target Neighborhood Hits	107	Shared Neighborhood Hits	44
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

TRPV3_HUMAN
θ value	0.0563607 (rank : 52)	NC score	0.146659 (rank : 56)
Query Neighborhood Hits	84	Target Neighborhood Hits	198	Shared Neighborhood Hits	44
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

SCN5A_HUMAN
θ value	0.125558 (rank : 53)	NC score	0.293199 (rank : 31)
Query Neighborhood Hits	84	Target Neighborhood Hits	145	Shared Neighborhood Hits	43
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

ENPL_HUMAN
θ value	0.163984 (rank : 54)	NC score	0.043679 (rank : 80)
Query Neighborhood Hits	84	Target Neighborhood Hits	68	Shared Neighborhood Hits	5
SwissProt Accessions	P14625, Q96A97	Gene names	HSP90B1, TRA1
Domain Architecture
Description	Endoplasmin precursor (Heat shock protein 90 kDa beta member 1) (94 kDa glucose-regulated protein) (GRP94) (gp96 homolog) (Tumor rejection antigen 1).

TRPV3_MOUSE
θ value	0.21417 (rank : 55)	NC score	0.130947 (rank : 60)
Query Neighborhood Hits	84	Target Neighborhood Hits	188	Shared Neighborhood Hits	40
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

TRPV5_MOUSE
θ value	0.279714 (rank : 56)	NC score	0.123882 (rank : 61)
Query Neighborhood Hits	84	Target Neighborhood Hits	278	Shared Neighborhood Hits	31
SwissProt Accessions	P69744	Gene names	Trpv5
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC1) (Calcium transport protein 2) (CaT2).

ENPL_MOUSE
θ value	0.365318 (rank : 57)	NC score	0.041813 (rank : 81)
Query Neighborhood Hits	84	Target Neighborhood Hits	78	Shared Neighborhood Hits	4
SwissProt Accessions	P08113, P11427	Gene names	Hsp90b1, Tra-1, Tra1
Domain Architecture
Description	Endoplasmin precursor (Heat shock protein 90 kDa beta member 1) (94 kDa glucose-regulated protein) (GRP94) (ERP99) (Polymorphic tumor rejection antigen 1) (Tumor rejection antigen gp96).

FBX15_HUMAN
θ value	0.47712 (rank : 58)	NC score	0.035131 (rank : 82)
Query Neighborhood Hits	84	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NCQ5	Gene names	FBXO15, FBX15
Domain Architecture	No domain graphic available
Description	F-box only protein 15.

TRPC5_HUMAN
θ value	0.47712 (rank : 59)	NC score	0.173846 (rank : 54)
Query Neighborhood Hits	84	Target Neighborhood Hits	122	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UL62, O75233, Q5JXY8, Q9Y514	Gene names	TRPC5, TRP5
Domain Architecture
Description	Short transient receptor potential channel 5 (TrpC5) (Htrp-5) (Htrp5).

TRPC5_MOUSE
θ value	0.47712 (rank : 60)	NC score	0.173605 (rank : 55)
Query Neighborhood Hits	84	Target Neighborhood Hits	124	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QX29, Q61059, Q9QWT1, Q9R0D4	Gene names	Trpc5, Trp5, Trrp5
Domain Architecture
Description	Short transient receptor potential channel 5 (TrpC5) (Transient receptor protein 5) (Mtrp5) (trp-related protein 5) (Capacitative calcium entry channel 2) (CCE2).

TRPV4_HUMAN
θ value	0.62314 (rank : 61)	NC score	0.114537 (rank : 65)
Query Neighborhood Hits	84	Target Neighborhood Hits	150	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TRPV4_MOUSE
θ value	0.62314 (rank : 62)	NC score	0.113934 (rank : 66)
Query Neighborhood Hits	84	Target Neighborhood Hits	117	Shared Neighborhood Hits	39
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

SCN8A_HUMAN
θ value	1.06291 (rank : 63)	NC score	0.258838 (rank : 41)
Query Neighborhood Hits	84	Target Neighborhood Hits	135	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN8A_MOUSE
θ value	1.06291 (rank : 64)	NC score	0.258605 (rank : 42)
Query Neighborhood Hits	84	Target Neighborhood Hits	136	Shared Neighborhood Hits	43
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

AKAP9_HUMAN
θ value	1.38821 (rank : 65)	NC score	0.007505 (rank : 91)
Query Neighborhood Hits	84	Target Neighborhood Hits	1710	Shared Neighborhood Hits	16
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

GOG8A_HUMAN
θ value	1.38821 (rank : 66)	NC score	0.012149 (rank : 87)
Query Neighborhood Hits	84	Target Neighborhood Hits	635	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NZW0, O94937, Q9NZG8, Q9NZW3	Gene names	GOLGA8A, KIAA0855
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 8A/B (Golgi autoantigen golgin-67) (88 kDa Golgi protein) (Gm88 autoantigen).

CENPJ_HUMAN
θ value	1.81305 (rank : 67)	NC score	0.014019 (rank : 86)
Query Neighborhood Hits	84	Target Neighborhood Hits	721	Shared Neighborhood Hits	7
SwissProt Accessions	Q9HC77, Q5T6R5, Q96KS5, Q9C067	Gene names	CENPJ, CPAP, LAP, LIP1
Domain Architecture	No domain graphic available
Description	Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1).

CAC1H_HUMAN
θ value	2.36792 (rank : 68)	NC score	0.256400 (rank : 43)
Query Neighborhood Hits	84	Target Neighborhood Hits	307	Shared Neighborhood Hits	39
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

CAC1H_MOUSE
θ value	2.36792 (rank : 69)	NC score	0.251887 (rank : 44)
Query Neighborhood Hits	84	Target Neighborhood Hits	230	Shared Neighborhood Hits	36
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

ITPR1_HUMAN
θ value	4.03905 (rank : 70)	NC score	0.019037 (rank : 84)
Query Neighborhood Hits	84	Target Neighborhood Hits	90	Shared Neighborhood Hits	8
SwissProt Accessions	Q14643, Q14660, Q99897	Gene names	ITPR1, INSP3R1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (IP3R).

ITPR1_MOUSE
θ value	4.03905 (rank : 71)	NC score	0.019034 (rank : 85)
Query Neighborhood Hits	84	Target Neighborhood Hits	99	Shared Neighborhood Hits	8
SwissProt Accessions	P11881, P20943, Q99LG5	Gene names	Itpr1, Insp3r, Pcd6, Pcp1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (Inositol 1,4,5-trisphosphate-binding protein P400) (Purkinje cell protein 1) (Protein PCD-6).

MRP9_HUMAN
θ value	4.03905 (rank : 72)	NC score	0.011325 (rank : 88)
Query Neighborhood Hits	84	Target Neighborhood Hits	114	Shared Neighborhood Hits	4
SwissProt Accessions	Q96J65, Q49AL2, Q8TAF0, Q8TEY2	Gene names	ABCC12, MRP9
Domain Architecture	No domain graphic available
Description	Multidrug resistance-associated protein 9 (ATP-binding cassette transporter sub-family C member 12).

SPTN5_HUMAN
θ value	4.03905 (rank : 73)	NC score	0.005140 (rank : 93)
Query Neighborhood Hits	84	Target Neighborhood Hits	674	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

ANR26_MOUSE
θ value	5.27518 (rank : 74)	NC score	0.008489 (rank : 89)
Query Neighborhood Hits	84	Target Neighborhood Hits	1554	Shared Neighborhood Hits	23
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

KU70_HUMAN
θ value	5.27518 (rank : 75)	NC score	0.029835 (rank : 83)
Query Neighborhood Hits	84	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	P12956, Q9UCQ2, Q9UCQ3	Gene names	XRCC6, G22P1
Domain Architecture
Description	ATP-dependent DNA helicase 2 subunit 1 (EC 3.6.1.-) (ATP-dependent DNA helicase II 70 kDa subunit) (Lupus Ku autoantigen protein p70) (Ku70) (70 kDa subunit of Ku antigen) (Thyroid-lupus autoantigen) (TLAA) (CTC box-binding factor 75 kDa subunit) (CTCBF) (CTC75) (DNA-repair protein XRCC6).

TRPV6_HUMAN
θ value	5.27518 (rank : 76)	NC score	0.085077 (rank : 71)
Query Neighborhood Hits	84	Target Neighborhood Hits	262	Shared Neighborhood Hits	29
SwissProt Accessions	Q9H1D0, Q8TDL3, Q8WXR8, Q96LC5, Q9H1D1, Q9H296	Gene names	TRPV6, ECAC2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1) (CaT-like) (CaT-L).

DYHC_HUMAN
θ value	6.88961 (rank : 77)	NC score	0.005130 (rank : 94)
Query Neighborhood Hits	84	Target Neighborhood Hits	733	Shared Neighborhood Hits	10
SwissProt Accessions	Q14204, Q6DKQ7, Q8WU28, Q92814, Q9Y4G5	Gene names	DYNC1H1, DNCH1, DNECL, KIAA0325
Domain Architecture	No domain graphic available
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

TRPV5_HUMAN
θ value	6.88961 (rank : 78)	NC score	0.093712 (rank : 68)
Query Neighborhood Hits	84	Target Neighborhood Hits	261	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NQA5, Q8NDW5, Q8NDX7, Q8NDX8, Q96PM6	Gene names	TRPV5, ECAC1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Calcium transport protein 2) (CaT2).

AKAP2_MOUSE
θ value	8.99809 (rank : 79)	NC score	0.007749 (rank : 90)
Query Neighborhood Hits	84	Target Neighborhood Hits	385	Shared Neighborhood Hits	6
SwissProt Accessions	O54931, O54932, O54933	Gene names	Akap2
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2) (AKAP expressed in kidney and lung) (AKAP-KL).

CT2NL_HUMAN
θ value	8.99809 (rank : 80)	NC score	0.003709 (rank : 95)
Query Neighborhood Hits	84	Target Neighborhood Hits	1059	Shared Neighborhood Hits	14
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

NEK1_MOUSE
θ value	8.99809 (rank : 81)	NC score	-0.004496 (rank : 98)
Query Neighborhood Hits	84	Target Neighborhood Hits	1311	Shared Neighborhood Hits	7
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).

RPA2_MOUSE
θ value	8.99809 (rank : 82)	NC score	0.006308 (rank : 92)
Query Neighborhood Hits	84	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	P70700	Gene names	Polr1b, Rpa2, Rpo1-2
Domain Architecture
Description	DNA-directed RNA polymerase I 135 kDa polypeptide (EC 2.7.7.6) (RNA polymerase I subunit 2) (RPA135).

SYNE1_HUMAN
θ value	8.99809 (rank : 83)	NC score	0.002841 (rank : 96)
Query Neighborhood Hits	84	Target Neighborhood Hits	1484	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

ZN306_HUMAN
θ value	8.99809 (rank : 84)	NC score	-0.004312 (rank : 97)
Query Neighborhood Hits	84	Target Neighborhood Hits	757	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BRR0, Q5VXH3, Q92972, Q9H4T3	Gene names	ZNF306, ZFP47, ZSCAN13
Domain Architecture
Description	Zinc finger protein 306 (Zinc finger protein 47 homolog) (Zfp-47) (Zf47) (Zinc finger and SCAN domain-containing protein 13).

SCN7A_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.250235 (rank : 45)
Query Neighborhood Hits	84	Target Neighborhood Hits	135	Shared Neighborhood Hits	38
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

TRPC1_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.135228 (rank : 59)
Query Neighborhood Hits	84	Target Neighborhood Hits	91	Shared Neighborhood Hits	30
SwissProt Accessions	P48995	Gene names	TRPC1, TRP1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (TRP-1 protein).

TRPC1_MOUSE
θ value	θ > 10 (rank : 87)	NC score	0.135314 (rank : 58)
Query Neighborhood Hits	84	Target Neighborhood Hits	87	Shared Neighborhood Hits	30
SwissProt Accessions	Q61056, O35722	Gene names	Trpc1, Trp1, Trrp1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (Mtrp1) (Trp-related protein 1).

TRPC2_MOUSE
θ value	θ > 10 (rank : 88)	NC score	0.137708 (rank : 57)
Query Neighborhood Hits	84	Target Neighborhood Hits	84	Shared Neighborhood Hits	22
SwissProt Accessions	Q9R244, Q9ES59, Q9ES60, Q9R243	Gene names	Trpc2, Trp2, Trrp2
Domain Architecture
Description	Short transient receptor potential channel 2 (TrpC2) (mTrp2).

TRPM2_HUMAN
θ value	θ > 10 (rank : 89)	NC score	0.064205 (rank : 75)
Query Neighborhood Hits	84	Target Neighborhood Hits	64	Shared Neighborhood Hits	22
SwissProt Accessions	O94759, Q5KTC2, Q6J3P5, Q96KN6, Q96Q93	Gene names	TRPM2, EREG1, KNP3, LTRPC2, TRPC7
Domain Architecture
Description	Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC2) (LTrpC-2) (Transient receptor potential channel 7) (TrpC7) (Estrogen- responsive element-associated gene 1 protein).

TRPM2_MOUSE
θ value	θ > 10 (rank : 90)	NC score	0.062254 (rank : 77)
Query Neighborhood Hits	84	Target Neighborhood Hits	61	Shared Neighborhood Hits	26
SwissProt Accessions	Q91YD4	Gene names	Trpm2, Ltrpc2, Trpc7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC2) (LTrpC-2) (Transient receptor potential channel 7) (TrpC7).

TRPM3_HUMAN
θ value	θ > 10 (rank : 91)	NC score	0.061651 (rank : 78)
Query Neighborhood Hits	84	Target Neighborhood Hits	121	Shared Neighborhood Hits	21
SwissProt Accessions	Q9HCF6, Q5VW02, Q5VW03, Q5VW04, Q5W5T7, Q86SH0, Q86SH6, Q86UL0, Q86WK1, Q86WK2, Q86WK3, Q86WK4, Q86YZ9, Q86Z00, Q86Z01	Gene names	TRPM3, KIAA1616, LTRPC3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC3) (Melastatin-2) (MLSN2).

TRPM6_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.068199 (rank : 74)
Query Neighborhood Hits	84	Target Neighborhood Hits	91	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BX84, Q6VPR8, Q6VPR9, Q6VPS0, Q6VPS1, Q6VPS2	Gene names	TRPM6, CHAK2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6).

TRPM6_MOUSE
θ value	θ > 10 (rank : 93)	NC score	0.069253 (rank : 73)
Query Neighborhood Hits	84	Target Neighborhood Hits	78	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CIR4	Gene names	Trpm6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6).

TRPM8_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.086985 (rank : 70)
Query Neighborhood Hits	84	Target Neighborhood Hits	65	Shared Neighborhood Hits	31
SwissProt Accessions	Q7Z2W7, Q6QNH9, Q8TAC3, Q8TDX8, Q9BVK1	Gene names	TRPM8, LTRPC6, TRPP8
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 8 (Transient receptor potential-p8) (Trp-p8) (Long transient receptor potential channel 6) (LTrpC6).

TRPM8_MOUSE
θ value	θ > 10 (rank : 95)	NC score	0.089101 (rank : 69)
Query Neighborhood Hits	84	Target Neighborhood Hits	58	Shared Neighborhood Hits	29
SwissProt Accessions	Q8R4D5	Gene names	Trpm8, Trpp8
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 8.

TRPV1_HUMAN
θ value	θ > 10 (rank : 96)	NC score	0.064148 (rank : 76)
Query Neighborhood Hits	84	Target Neighborhood Hits	184	Shared Neighborhood Hits	32
SwissProt Accessions	Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22	Gene names	TRPV1, VR1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Capsaicin receptor).

TRPV1_MOUSE
θ value	θ > 10 (rank : 97)	NC score	0.060255 (rank : 79)
Query Neighborhood Hits	84	Target Neighborhood Hits	189	Shared Neighborhood Hits	28
SwissProt Accessions	Q704Y3, Q5SSE1, Q5SSE2, Q5SSE4, Q5WPV5, Q68SW0	Gene names	Trpv1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1).

TRPV6_MOUSE
θ value	θ > 10 (rank : 98)	NC score	0.079154 (rank : 72)
Query Neighborhood Hits	84	Target Neighborhood Hits	284	Shared Neighborhood Hits	29
SwissProt Accessions	Q91WD2	Gene names	Trpv6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1).

Hits sorted by NC score

PK2L2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	84	Target Neighborhood Hits	84	Shared Neighborhood Hits	84
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PK2L2_HUMAN
NC score	0.989577 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	84	Target Neighborhood Hits	90	Shared Neighborhood Hits	70
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PK2L1_HUMAN
NC score	0.963751 (rank : 3)	θ value	3.4016e-132 (rank : 4)
Query Neighborhood Hits	84	Target Neighborhood Hits	132	Shared Neighborhood Hits	67
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

PKD2_HUMAN
NC score	0.961251 (rank : 4)	θ value	2.78268e-134 (rank : 3)
Query Neighborhood Hits	84	Target Neighborhood Hits	105	Shared Neighborhood Hits	64
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

PKD2_MOUSE
NC score	0.960207 (rank : 5)	θ value	7.09276e-130 (rank : 5)
Query Neighborhood Hits	84	Target Neighborhood Hits	99	Shared Neighborhood Hits	62
SwissProt Accessions	O35245, Q9QWP0, Q9Z193, Q9Z194	Gene names	Pkd2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog).

PKDRE_HUMAN
NC score	0.604381 (rank : 6)	θ value	9.24701e-21 (rank : 6)
Query Neighborhood Hits	84	Target Neighborhood Hits	64	Shared Neighborhood Hits	34
SwissProt Accessions	Q9NTG1, O95850	Gene names	PKDREJ
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

PKDRE_MOUSE
NC score	0.577463 (rank : 7)	θ value	9.24701e-21 (rank : 7)
Query Neighborhood Hits	84	Target Neighborhood Hits	76	Shared Neighborhood Hits	30
SwissProt Accessions	Q9Z0T6	Gene names	Pkdrej
Domain Architecture
Description	Polycystic kidney disease and receptor for egg jelly-related protein precursor (PKD and REJ homolog).

PK1L1_HUMAN
NC score	0.493587 (rank : 8)	θ value	3.40345e-15 (rank : 8)
Query Neighborhood Hits	84	Target Neighborhood Hits	140	Shared Neighborhood Hits	13
SwissProt Accessions	Q8TDX9, Q6UWK1	Gene names	PKD1L1
Domain Architecture
Description	Polycystic kidney disease 1-like 1 protein (Polycystin-1L1).

MCLN2_MOUSE
NC score	0.427578 (rank : 9)	θ value	1.9326e-10 (rank : 10)
Query Neighborhood Hits	84	Target Neighborhood Hits	31	Shared Neighborhood Hits	25
SwissProt Accessions	Q8K595, Q3UCG4, Q8K2T6, Q9CQD3	Gene names	Mcoln2
Domain Architecture	No domain graphic available
Description	Mucolipin-2.

MCLN2_HUMAN
NC score	0.418132 (rank : 10)	θ value	3.64472e-09 (rank : 13)
Query Neighborhood Hits	84	Target Neighborhood Hits	23	Shared Neighborhood Hits	22
SwissProt Accessions	Q8IZK6, Q8N9R3	Gene names	MCOLN2
Domain Architecture	No domain graphic available
Description	Mucolipin-2.

MCLN3_HUMAN
NC score	0.414704 (rank : 11)	θ value	2.52405e-10 (rank : 11)
Query Neighborhood Hits	84	Target Neighborhood Hits	26	Shared Neighborhood Hits	23
SwissProt Accessions	Q8TDD5, Q5T4H5, Q5T4H6, Q9NV09	Gene names	MCOLN3
Domain Architecture	No domain graphic available
Description	Mucolipin-3.

MCLN3_MOUSE
NC score	0.412204 (rank : 12)	θ value	3.29651e-10 (rank : 12)
Query Neighborhood Hits	84	Target Neighborhood Hits	29	Shared Neighborhood Hits	24
SwissProt Accessions	Q8R4F0, Q8BS73, Q8BSG1, Q8CDB2	Gene names	Mcoln3
Domain Architecture	No domain graphic available
Description	Mucolipin-3.

MCLN1_HUMAN
NC score	0.379211 (rank : 13)	θ value	9.92553e-07 (rank : 19)
Query Neighborhood Hits	84	Target Neighborhood Hits	26	Shared Neighborhood Hits	16
SwissProt Accessions	Q9GZU1, Q7Z4F7, Q9H292, Q9H4B3, Q9H4B5	Gene names	MCOLN1, ML4
Domain Architecture	No domain graphic available
Description	Mucolipin-1 (Mucolipidin) (MG-2).

MCLN1_MOUSE
NC score	0.374417 (rank : 14)	θ value	1.29631e-06 (rank : 21)
Query Neighborhood Hits	84	Target Neighborhood Hits	24	Shared Neighborhood Hits	17
SwissProt Accessions	Q99J21	Gene names	Mcoln1
Domain Architecture	No domain graphic available
Description	Mucolipin-1 (Mucolipidin).

CAC1F_MOUSE
NC score	0.359244 (rank : 15)	θ value	1.17247e-07 (rank : 14)
Query Neighborhood Hits	84	Target Neighborhood Hits	142	Shared Neighborhood Hits	36
SwissProt Accessions	Q9JIS7	Gene names	Cacna1f
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1F_HUMAN
NC score	0.355427 (rank : 16)	θ value	5.81887e-07 (rank : 18)
Query Neighborhood Hits	84	Target Neighborhood Hits	141	Shared Neighborhood Hits	34
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

CAC1C_MOUSE
NC score	0.354284 (rank : 17)	θ value	1.99992e-07 (rank : 17)
Query Neighborhood Hits	84	Target Neighborhood Hits	130	Shared Neighborhood Hits	35
SwissProt Accessions	Q01815, Q04476, Q61242, Q99242	Gene names	Cacna1c, Cach2, Cacn2, Cacnl1a1, Cchl1a1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Mouse brain class C) (MBC) (MELC-CC).

CAC1C_HUMAN
NC score	0.353315 (rank : 18)	θ value	1.53129e-07 (rank : 15)
Query Neighborhood Hits	84	Target Neighborhood Hits	158	Shared Neighborhood Hits	36
SwissProt Accessions	Q13936, Q13917, Q13918, Q13919, Q13920, Q13921, Q13922, Q13923, Q13924, Q13925, Q13926, Q13927, Q13928, Q13929, Q13930, Q13932, Q13933, Q14743, Q14744, Q15877, Q99025, Q99241, Q99875	Gene names	CACNA1C, CACH2, CACN2, CACNL1A1, CCHL1A1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1C (Voltage- gated calcium channel subunit alpha Cav1.2) (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle).

CAC1E_MOUSE
NC score	0.349167 (rank : 19)	θ value	4.92598e-06 (rank : 22)
Query Neighborhood Hits	84	Target Neighborhood Hits	167	Shared Neighborhood Hits	39
SwissProt Accessions	Q61290	Gene names	Cacna1e, Cach6, Cacnl1a6, Cchra1
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1E_HUMAN
NC score	0.348640 (rank : 20)	θ value	1.29631e-06 (rank : 20)
Query Neighborhood Hits	84	Target Neighborhood Hits	148	Shared Neighborhood Hits	39
SwissProt Accessions	Q15878, Q14580, Q14581	Gene names	CACNA1E, CACH6, CACNL1A6
Domain Architecture
Description	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) (BII).

CAC1D_HUMAN
NC score	0.347207 (rank : 21)	θ value	1.53129e-07 (rank : 16)
Query Neighborhood Hits	84	Target Neighborhood Hits	118	Shared Neighborhood Hits	37
SwissProt Accessions	Q01668, Q13916, Q13931	Gene names	CACNA1D, CACH3, CACN4, CACNL1A2, CCHL1A2
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1D (Voltage- gated calcium channel subunit alpha Cav1.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 2).

CAC1B_HUMAN
NC score	0.344137 (rank : 22)	θ value	7.1131e-05 (rank : 24)
Query Neighborhood Hits	84	Target Neighborhood Hits	257	Shared Neighborhood Hits	45
SwissProt Accessions	Q00975	Gene names	CACNA1B, CACH5, CACNL1A5
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1S_HUMAN
NC score	0.337598 (rank : 23)	θ value	0.000270298 (rank : 30)
Query Neighborhood Hits	84	Target Neighborhood Hits	92	Shared Neighborhood Hits	35
SwissProt Accessions	Q13698, Q12896, Q13934	Gene names	CACNA1S, CACH1, CACN1, CACNL1A3
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1S_MOUSE
NC score	0.335092 (rank : 24)	θ value	0.000602161 (rank : 32)
Query Neighborhood Hits	84	Target Neighborhood Hits	98	Shared Neighborhood Hits	34
SwissProt Accessions	Q02789, Q99240	Gene names	Cacna1s, Cach1, Cach1b, Cacn1, Cacnl1a3
Domain Architecture	No domain graphic available
Description	Voltage-dependent L-type calcium channel subunit alpha-1S (Voltage- gated calcium channel subunit alpha Cav1.1) (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle).

CAC1B_MOUSE
NC score	0.334611 (rank : 25)	θ value	0.000461057 (rank : 31)
Query Neighborhood Hits	84	Target Neighborhood Hits	351	Shared Neighborhood Hits	43
SwissProt Accessions	O55017, Q60609	Gene names	Cacna1b, Cach5, Cacnl1a5, Cchn1a
Domain Architecture
Description	Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII).

CAC1A_MOUSE
NC score	0.320941 (rank : 26)	θ value	0.00134147 (rank : 38)
Query Neighborhood Hits	84	Target Neighborhood Hits	267	Shared Neighborhood Hits	40
SwissProt Accessions	P97445	Gene names	Cacna1a, Cach4, Cacn3, Cacnl1a4, Ccha1a
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

CAC1A_HUMAN
NC score	0.318708 (rank : 27)	θ value	0.00134147 (rank : 37)
Query Neighborhood Hits	84	Target Neighborhood Hits	387	Shared Neighborhood Hits	40
SwissProt Accessions	O00555, P78510, P78511, Q16290, Q92690, Q99790, Q99791, Q99792, Q99793	Gene names	CACNA1A, CACH4, CACN3, CACNL1A4
Domain Architecture
Description	Voltage-dependent P/Q-type calcium channel subunit alpha-1A (Voltage- gated calcium channel subunit alpha Cav2.1) (Calcium channel, L type, alpha-1 polypeptide isoform 4) (Brain calcium channel I) (BI).

SC11A_HUMAN
NC score	0.302213 (rank : 28)	θ value	0.000786445 (rank : 34)
Query Neighborhood Hits	84	Target Neighborhood Hits	111	Shared Neighborhood Hits	43
SwissProt Accessions	Q9UI33, Q68K15, Q8NDX3, Q9UHE0, Q9UHM0	Gene names	SCN11A, PN5, SCN12A, SNS2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (Peripheral nerve sodium channel 5) (hNaN).

PKD1_HUMAN
NC score	0.301707 (rank : 29)	θ value	7.84624e-12 (rank : 9)
Query Neighborhood Hits	84	Target Neighborhood Hits	387	Shared Neighborhood Hits	9
SwissProt Accessions	P98161, Q15140, Q15141	Gene names	PKD1
Domain Architecture
Description	Polycystin-1 precursor (Autosomal dominant polycystic kidney disease protein 1).

CAC1I_HUMAN
NC score	0.294266 (rank : 30)	θ value	0.00869519 (rank : 42)
Query Neighborhood Hits	84	Target Neighborhood Hits	138	Shared Neighborhood Hits	35
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

SCN5A_HUMAN
NC score	0.293199 (rank : 31)	θ value	0.125558 (rank : 53)
Query Neighborhood Hits	84	Target Neighborhood Hits	145	Shared Neighborhood Hits	43
SwissProt Accessions	Q14524	Gene names	SCN5A
Domain Architecture
Description	Sodium channel protein type 5 subunit alpha (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (Sodium channel protein, cardiac muscle alpha-subunit) (HH1).

SC11A_MOUSE
NC score	0.279146 (rank : 32)	θ value	0.0193708 (rank : 48)
Query Neighborhood Hits	84	Target Neighborhood Hits	116	Shared Neighborhood Hits	46
SwissProt Accessions	Q9R053, Q9JMD4	Gene names	Scn11a, Nan, Nat, Sns2
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 11 subunit alpha (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9) (Sensory neuron sodium channel 2) (NaN).

SCN9A_HUMAN
NC score	0.274068 (rank : 33)	θ value	0.000602161 (rank : 33)
Query Neighborhood Hits	84	Target Neighborhood Hits	157	Shared Neighborhood Hits	40
SwissProt Accessions	Q15858, Q6B4R9, Q6B4S0, Q6B4S1, Q70HX1, Q70HX2, Q8WTU1, Q8WWN4	Gene names	SCN9A, NENA, PN1
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 9 subunit alpha (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1).

SC10A_HUMAN
NC score	0.273964 (rank : 34)	θ value	0.00665767 (rank : 40)
Query Neighborhood Hits	84	Target Neighborhood Hits	116	Shared Neighborhood Hits	46
SwissProt Accessions	Q9Y5Y9	Gene names	SCN10A, PN3
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (hPN3).

SC10A_MOUSE
NC score	0.273142 (rank : 35)	θ value	0.0431538 (rank : 51)
Query Neighborhood Hits	84	Target Neighborhood Hits	107	Shared Neighborhood Hits	44
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

SCN1A_HUMAN
NC score	0.269667 (rank : 36)	θ value	0.0113563 (rank : 43)
Query Neighborhood Hits	84	Target Neighborhood Hits	148	Shared Neighborhood Hits	42
SwissProt Accessions	P35498, Q16172, Q96LA3, Q9C008	Gene names	SCN1A, NAC1, SCN1
Domain Architecture
Description	Sodium channel protein type 1 subunit alpha (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) (Sodium channel protein, brain I subunit alpha).

SCN2A_HUMAN
NC score	0.269346 (rank : 37)	θ value	0.0113563 (rank : 44)
Query Neighborhood Hits	84	Target Neighborhood Hits	157	Shared Neighborhood Hits	41
SwissProt Accessions	Q99250, Q14472, Q9BZC9, Q9BZD0	Gene names	SCN2A, NAC2, SCN2A2
Domain Architecture
Description	Sodium channel protein type 2 subunit alpha (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) (Sodium channel protein, brain II subunit alpha) (HBSC II).

CAC1G_HUMAN
NC score	0.268766 (rank : 38)	θ value	0.0431538 (rank : 50)
Query Neighborhood Hits	84	Target Neighborhood Hits	587	Shared Neighborhood Hits	43
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

SCN4A_HUMAN
NC score	0.268555 (rank : 39)	θ value	0.0148317 (rank : 47)
Query Neighborhood Hits	84	Target Neighborhood Hits	133	Shared Neighborhood Hits	43
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

SCN3A_HUMAN
NC score	0.268337 (rank : 40)	θ value	0.0193708 (rank : 49)
Query Neighborhood Hits	84	Target Neighborhood Hits	115	Shared Neighborhood Hits	42
SwissProt Accessions	Q9NY46, Q16142, Q9BZB3, Q9C006, Q9NYK2, Q9UPD1, Q9Y6P4	Gene names	SCN3A, NAC3
Domain Architecture
Description	Sodium channel protein type 3 subunit alpha (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.3) (Sodium channel protein, brain III subunit alpha) (Voltage- gated sodium channel subtype III).

SCN8A_HUMAN
NC score	0.258838 (rank : 41)	θ value	1.06291 (rank : 63)
Query Neighborhood Hits	84	Target Neighborhood Hits	135	Shared Neighborhood Hits	42
SwissProt Accessions	Q9UQD0, O95788, Q9NYX2, Q9UPB2	Gene names	SCN8A
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

SCN8A_MOUSE
NC score	0.258605 (rank : 42)	θ value	1.06291 (rank : 64)
Query Neighborhood Hits	84	Target Neighborhood Hits	136	Shared Neighborhood Hits	43
SwissProt Accessions	Q9WTU3, Q60828, Q60858, Q62449	Gene names	Scn8a, Nbna1
Domain Architecture
Description	Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6).

CAC1H_HUMAN
NC score	0.256400 (rank : 43)	θ value	2.36792 (rank : 68)
Query Neighborhood Hits	84	Target Neighborhood Hits	307	Shared Neighborhood Hits	39
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

CAC1H_MOUSE
NC score	0.251887 (rank : 44)	θ value	2.36792 (rank : 69)
Query Neighborhood Hits	84	Target Neighborhood Hits	230	Shared Neighborhood Hits	36
SwissProt Accessions	O88427, Q80TJ2, Q9JKU5	Gene names	Cacna1h, Kiaa1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2).

SCN7A_HUMAN
NC score	0.250235 (rank : 45)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	84	Target Neighborhood Hits	135	Shared Neighborhood Hits	38
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

TRPC3_MOUSE
NC score	0.227108 (rank : 46)	θ value	9.29e-05 (rank : 25)
Query Neighborhood Hits	84	Target Neighborhood Hits	131	Shared Neighborhood Hits	26
SwissProt Accessions	Q9QZC1, Q61058	Gene names	Trpc3, Trp3, Trrp3
Domain Architecture
Description	Short transient receptor potential channel 3 (TrpC3) (Transient receptor protein 3) (Mtrp3) (Receptor-activated cation channel TRP3) (trp-related protein 3).

TRPC3_HUMAN
NC score	0.225848 (rank : 47)	θ value	0.000121331 (rank : 28)
Query Neighborhood Hits	84	Target Neighborhood Hits	137	Shared Neighborhood Hits	26
SwissProt Accessions	Q13507, O00593, Q15660	Gene names	TRPC3, TRP3
Domain Architecture
Description	Short transient receptor potential channel 3 (TrpC3) (Htrp-3) (Htrp3).

TRPC6_MOUSE
NC score	0.209137 (rank : 48)	θ value	9.29e-05 (rank : 27)
Query Neighborhood Hits	84	Target Neighborhood Hits	171	Shared Neighborhood Hits	26
SwissProt Accessions	Q61143, Q9Z2J1	Gene names	Trpc6, Trp6, Trrp6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6) (Calcium entry channel).

TRPC6_HUMAN
NC score	0.208433 (rank : 49)	θ value	9.29e-05 (rank : 26)
Query Neighborhood Hits	84	Target Neighborhood Hits	171	Shared Neighborhood Hits	26
SwissProt Accessions	Q9Y210, Q9HCW3, Q9NQA8, Q9NQA9	Gene names	TRPC6, TRP6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6).

TRPC4_HUMAN
NC score	0.207212 (rank : 50)	θ value	0.0113563 (rank : 45)
Query Neighborhood Hits	84	Target Neighborhood Hits	140	Shared Neighborhood Hits	40
SwissProt Accessions	Q9UBN4, Q15721, Q9UIB0, Q9UIB1, Q9UIB2	Gene names	TRPC4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (trp-related protein 4) (hTrp-4) (hTrp4).

TRPC4_MOUSE
NC score	0.206811 (rank : 51)	θ value	0.0113563 (rank : 46)
Query Neighborhood Hits	84	Target Neighborhood Hits	141	Shared Neighborhood Hits	37
SwissProt Accessions	Q9QUQ5, Q62350, Q9QUQ9, Q9QZC0	Gene names	Trpc4, Trrp4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (Receptor- activated cation channel TRP4) (Capacitative calcium entry channel Trp4).

TRPC7_MOUSE
NC score	0.193294 (rank : 52)	θ value	0.000786445 (rank : 36)
Query Neighborhood Hits	84	Target Neighborhood Hits	114	Shared Neighborhood Hits	26
SwissProt Accessions	Q9WVC5	Gene names	Trpc7, Trp7, Trrp8
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (mTRP7).

TRPC7_HUMAN
NC score	0.193164 (rank : 53)	θ value	0.000786445 (rank : 35)
Query Neighborhood Hits	84	Target Neighborhood Hits	123	Shared Neighborhood Hits	26
SwissProt Accessions	Q9HCX4	Gene names	TRPC7, TRP7
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (TRP7 protein).

TRPC5_HUMAN
NC score	0.173846 (rank : 54)	θ value	0.47712 (rank : 59)
Query Neighborhood Hits	84	Target Neighborhood Hits	122	Shared Neighborhood Hits	29
SwissProt Accessions	Q9UL62, O75233, Q5JXY8, Q9Y514	Gene names	TRPC5, TRP5
Domain Architecture
Description	Short transient receptor potential channel 5 (TrpC5) (Htrp-5) (Htrp5).

TRPC5_MOUSE
NC score	0.173605 (rank : 55)	θ value	0.47712 (rank : 60)
Query Neighborhood Hits	84	Target Neighborhood Hits	124	Shared Neighborhood Hits	28
SwissProt Accessions	Q9QX29, Q61059, Q9QWT1, Q9R0D4	Gene names	Trpc5, Trp5, Trrp5
Domain Architecture
Description	Short transient receptor potential channel 5 (TrpC5) (Transient receptor protein 5) (Mtrp5) (trp-related protein 5) (Capacitative calcium entry channel 2) (CCE2).

TRPV3_HUMAN
NC score	0.146659 (rank : 56)	θ value	0.0563607 (rank : 52)
Query Neighborhood Hits	84	Target Neighborhood Hits	198	Shared Neighborhood Hits	44
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

TRPC2_MOUSE
NC score	0.137708 (rank : 57)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	84	Target Neighborhood Hits	84	Shared Neighborhood Hits	22
SwissProt Accessions	Q9R244, Q9ES59, Q9ES60, Q9R243	Gene names	Trpc2, Trp2, Trrp2
Domain Architecture
Description	Short transient receptor potential channel 2 (TrpC2) (mTrp2).

TRPC1_MOUSE
NC score	0.135314 (rank : 58)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	84	Target Neighborhood Hits	87	Shared Neighborhood Hits	30
SwissProt Accessions	Q61056, O35722	Gene names	Trpc1, Trp1, Trrp1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (Mtrp1) (Trp-related protein 1).

TRPC1_HUMAN
NC score	0.135228 (rank : 59)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	84	Target Neighborhood Hits	91	Shared Neighborhood Hits	30
SwissProt Accessions	P48995	Gene names	TRPC1, TRP1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (TRP-1 protein).

TRPV3_MOUSE
NC score	0.130947 (rank : 60)	θ value	0.21417 (rank : 55)
Query Neighborhood Hits	84	Target Neighborhood Hits	188	Shared Neighborhood Hits	40
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

TRPV5_MOUSE
NC score	0.123882 (rank : 61)	θ value	0.279714 (rank : 56)
Query Neighborhood Hits	84	Target Neighborhood Hits	278	Shared Neighborhood Hits	31
SwissProt Accessions	P69744	Gene names	Trpv5
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC1) (Calcium transport protein 2) (CaT2).

TRPA1_HUMAN
NC score	0.119832 (rank : 62)	θ value	8.40245e-06 (rank : 23)
Query Neighborhood Hits	84	Target Neighborhood Hits	339	Shared Neighborhood Hits	26
SwissProt Accessions	O75762	Gene names	TRPA1, ANKTM1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Transformation sensitive-protein p120).

TRPM7_MOUSE
NC score	0.118364 (rank : 63)	θ value	0.00665767 (rank : 41)
Query Neighborhood Hits	84	Target Neighborhood Hits	113	Shared Neighborhood Hits	27
SwissProt Accessions	Q923J1, Q8C7S7, Q8CE54, Q921Y5, Q925B2, Q9CUT2, Q9JLQ1	Gene names	Trpm7, Chak, Ltrpc7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Long transient receptor potential channel 7) (LTrpC7) (Channel-kinase 1) (Transient receptor potential-phospholipase C- interacting kinase) (TRP-PLIK).

TRPM7_HUMAN
NC score	0.116111 (rank : 64)	θ value	0.00228821 (rank : 39)
Query Neighborhood Hits	84	Target Neighborhood Hits	104	Shared Neighborhood Hits	25
SwissProt Accessions	Q96QT4, Q6ZMF5, Q86VJ4, Q8NBW2, Q9BXB2, Q9NXQ2	Gene names	TRPM7, CHAK1, LTRPC7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Long transient receptor potential channel 7) (LTrpC7) (Channel-kinase 1).

TRPV4_HUMAN
NC score	0.114537 (rank : 65)	θ value	0.62314 (rank : 61)
Query Neighborhood Hits	84	Target Neighborhood Hits	150	Shared Neighborhood Hits	39
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TRPV4_MOUSE
NC score	0.113934 (rank : 66)	θ value	0.62314 (rank : 62)
Query Neighborhood Hits	84	Target Neighborhood Hits	117	Shared Neighborhood Hits	39
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TRPA1_MOUSE
NC score	0.112636 (rank : 67)	θ value	0.000158464 (rank : 29)
Query Neighborhood Hits	84	Target Neighborhood Hits	343	Shared Neighborhood Hits	24
SwissProt Accessions	Q8BLA8	Gene names	Trpa1, Anktm1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1).

TRPV5_HUMAN
NC score	0.093712 (rank : 68)	θ value	6.88961 (rank : 78)
Query Neighborhood Hits	84	Target Neighborhood Hits	261	Shared Neighborhood Hits	33
SwissProt Accessions	Q9NQA5, Q8NDW5, Q8NDX7, Q8NDX8, Q96PM6	Gene names	TRPV5, ECAC1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Calcium transport protein 2) (CaT2).

TRPM8_MOUSE
NC score	0.089101 (rank : 69)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	84	Target Neighborhood Hits	58	Shared Neighborhood Hits	29
SwissProt Accessions	Q8R4D5	Gene names	Trpm8, Trpp8
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 8.

TRPM8_HUMAN
NC score	0.086985 (rank : 70)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	84	Target Neighborhood Hits	65	Shared Neighborhood Hits	31
SwissProt Accessions	Q7Z2W7, Q6QNH9, Q8TAC3, Q8TDX8, Q9BVK1	Gene names	TRPM8, LTRPC6, TRPP8
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 8 (Transient receptor potential-p8) (Trp-p8) (Long transient receptor potential channel 6) (LTrpC6).

TRPV6_HUMAN
NC score	0.085077 (rank : 71)	θ value	5.27518 (rank : 76)
Query Neighborhood Hits	84	Target Neighborhood Hits	262	Shared Neighborhood Hits	29
SwissProt Accessions	Q9H1D0, Q8TDL3, Q8WXR8, Q96LC5, Q9H1D1, Q9H296	Gene names	TRPV6, ECAC2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1) (CaT-like) (CaT-L).

TRPV6_MOUSE
NC score	0.079154 (rank : 72)	θ value	θ > 10 (rank : 98)
Query Neighborhood Hits	84	Target Neighborhood Hits	284	Shared Neighborhood Hits	29
SwissProt Accessions	Q91WD2	Gene names	Trpv6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1).

TRPM6_MOUSE
NC score	0.069253 (rank : 73)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	84	Target Neighborhood Hits	78	Shared Neighborhood Hits	19
SwissProt Accessions	Q8CIR4	Gene names	Trpm6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6).

TRPM6_HUMAN
NC score	0.068199 (rank : 74)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	84	Target Neighborhood Hits	91	Shared Neighborhood Hits	20
SwissProt Accessions	Q9BX84, Q6VPR8, Q6VPR9, Q6VPS0, Q6VPS1, Q6VPS2	Gene names	TRPM6, CHAK2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6).

TRPM2_HUMAN
NC score	0.064205 (rank : 75)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	84	Target Neighborhood Hits	64	Shared Neighborhood Hits	22
SwissProt Accessions	O94759, Q5KTC2, Q6J3P5, Q96KN6, Q96Q93	Gene names	TRPM2, EREG1, KNP3, LTRPC2, TRPC7
Domain Architecture
Description	Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC2) (LTrpC-2) (Transient receptor potential channel 7) (TrpC7) (Estrogen- responsive element-associated gene 1 protein).

TRPV1_HUMAN
NC score	0.064148 (rank : 76)	θ value	θ > 10 (rank : 96)
Query Neighborhood Hits	84	Target Neighborhood Hits	184	Shared Neighborhood Hits	32
SwissProt Accessions	Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22	Gene names	TRPV1, VR1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Capsaicin receptor).

TRPM2_MOUSE
NC score	0.062254 (rank : 77)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	84	Target Neighborhood Hits	61	Shared Neighborhood Hits	26
SwissProt Accessions	Q91YD4	Gene names	Trpm2, Ltrpc2, Trpc7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC2) (LTrpC-2) (Transient receptor potential channel 7) (TrpC7).

TRPM3_HUMAN
NC score	0.061651 (rank : 78)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	84	Target Neighborhood Hits	121	Shared Neighborhood Hits	21
SwissProt Accessions	Q9HCF6, Q5VW02, Q5VW03, Q5VW04, Q5W5T7, Q86SH0, Q86SH6, Q86UL0, Q86WK1, Q86WK2, Q86WK3, Q86WK4, Q86YZ9, Q86Z00, Q86Z01	Gene names	TRPM3, KIAA1616, LTRPC3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC3) (Melastatin-2) (MLSN2).

TRPV1_MOUSE
NC score	0.060255 (rank : 79)	θ value	θ > 10 (rank : 97)
Query Neighborhood Hits	84	Target Neighborhood Hits	189	Shared Neighborhood Hits	28
SwissProt Accessions	Q704Y3, Q5SSE1, Q5SSE2, Q5SSE4, Q5WPV5, Q68SW0	Gene names	Trpv1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1).

ENPL_HUMAN
NC score	0.043679 (rank : 80)	θ value	0.163984 (rank : 54)
Query Neighborhood Hits	84	Target Neighborhood Hits	68	Shared Neighborhood Hits	5
SwissProt Accessions	P14625, Q96A97	Gene names	HSP90B1, TRA1
Domain Architecture
Description	Endoplasmin precursor (Heat shock protein 90 kDa beta member 1) (94 kDa glucose-regulated protein) (GRP94) (gp96 homolog) (Tumor rejection antigen 1).

ENPL_MOUSE
NC score	0.041813 (rank : 81)	θ value	0.365318 (rank : 57)
Query Neighborhood Hits	84	Target Neighborhood Hits	78	Shared Neighborhood Hits	4
SwissProt Accessions	P08113, P11427	Gene names	Hsp90b1, Tra-1, Tra1
Domain Architecture
Description	Endoplasmin precursor (Heat shock protein 90 kDa beta member 1) (94 kDa glucose-regulated protein) (GRP94) (ERP99) (Polymorphic tumor rejection antigen 1) (Tumor rejection antigen gp96).

FBX15_HUMAN
NC score	0.035131 (rank : 82)	θ value	0.47712 (rank : 58)
Query Neighborhood Hits	84	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	Q8NCQ5	Gene names	FBXO15, FBX15
Domain Architecture	No domain graphic available
Description	F-box only protein 15.

KU70_HUMAN
NC score	0.029835 (rank : 83)	θ value	5.27518 (rank : 75)
Query Neighborhood Hits	84	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	P12956, Q9UCQ2, Q9UCQ3	Gene names	XRCC6, G22P1
Domain Architecture
Description	ATP-dependent DNA helicase 2 subunit 1 (EC 3.6.1.-) (ATP-dependent DNA helicase II 70 kDa subunit) (Lupus Ku autoantigen protein p70) (Ku70) (70 kDa subunit of Ku antigen) (Thyroid-lupus autoantigen) (TLAA) (CTC box-binding factor 75 kDa subunit) (CTCBF) (CTC75) (DNA-repair protein XRCC6).

ITPR1_HUMAN
NC score	0.019037 (rank : 84)	θ value	4.03905 (rank : 70)
Query Neighborhood Hits	84	Target Neighborhood Hits	90	Shared Neighborhood Hits	8
SwissProt Accessions	Q14643, Q14660, Q99897	Gene names	ITPR1, INSP3R1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (IP3R).

ITPR1_MOUSE
NC score	0.019034 (rank : 85)	θ value	4.03905 (rank : 71)
Query Neighborhood Hits	84	Target Neighborhood Hits	99	Shared Neighborhood Hits	8
SwissProt Accessions	P11881, P20943, Q99LG5	Gene names	Itpr1, Insp3r, Pcd6, Pcp1
Domain Architecture
Description	Inositol 1,4,5-trisphosphate receptor type 1 (Type 1 inositol 1,4,5- trisphosphate receptor) (Type 1 InsP3 receptor) (IP3 receptor isoform 1) (InsP3R1) (Inositol 1,4,5-trisphosphate-binding protein P400) (Purkinje cell protein 1) (Protein PCD-6).

CENPJ_HUMAN
NC score	0.014019 (rank : 86)	θ value	1.81305 (rank : 67)
Query Neighborhood Hits	84	Target Neighborhood Hits	721	Shared Neighborhood Hits	7
SwissProt Accessions	Q9HC77, Q5T6R5, Q96KS5, Q9C067	Gene names	CENPJ, CPAP, LAP, LIP1
Domain Architecture	No domain graphic available
Description	Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1).

GOG8A_HUMAN
NC score	0.012149 (rank : 87)	θ value	1.38821 (rank : 66)
Query Neighborhood Hits	84	Target Neighborhood Hits	635	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NZW0, O94937, Q9NZG8, Q9NZW3	Gene names	GOLGA8A, KIAA0855
Domain Architecture	No domain graphic available
Description	Golgin subfamily A member 8A/B (Golgi autoantigen golgin-67) (88 kDa Golgi protein) (Gm88 autoantigen).

MRP9_HUMAN
NC score	0.011325 (rank : 88)	θ value	4.03905 (rank : 72)
Query Neighborhood Hits	84	Target Neighborhood Hits	114	Shared Neighborhood Hits	4
SwissProt Accessions	Q96J65, Q49AL2, Q8TAF0, Q8TEY2	Gene names	ABCC12, MRP9
Domain Architecture	No domain graphic available
Description	Multidrug resistance-associated protein 9 (ATP-binding cassette transporter sub-family C member 12).

ANR26_MOUSE
NC score	0.008489 (rank : 89)	θ value	5.27518 (rank : 74)
Query Neighborhood Hits	84	Target Neighborhood Hits	1554	Shared Neighborhood Hits	23
SwissProt Accessions	Q811D2, Q69ZS2, Q9CS61	Gene names	Ankrd26, Kiaa1074
Domain Architecture	No domain graphic available
Description	Ankyrin repeat domain-containing protein 26.

AKAP2_MOUSE
NC score	0.007749 (rank : 90)	θ value	8.99809 (rank : 79)
Query Neighborhood Hits	84	Target Neighborhood Hits	385	Shared Neighborhood Hits	6
SwissProt Accessions	O54931, O54932, O54933	Gene names	Akap2
Domain Architecture	No domain graphic available
Description	A-kinase anchor protein 2 (Protein kinase A-anchoring protein 2) (PRKA2) (AKAP-2) (AKAP expressed in kidney and lung) (AKAP-KL).

AKAP9_HUMAN
NC score	0.007505 (rank : 91)	θ value	1.38821 (rank : 65)
Query Neighborhood Hits	84	Target Neighborhood Hits	1710	Shared Neighborhood Hits	16
SwissProt Accessions	Q99996, O14869, O43355, O94895, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2	Gene names	AKAP9, AKAP350, AKAP450, KIAA0803
Domain Architecture
Description	A-kinase anchor protein 9 (Protein kinase A-anchoring protein 9) (PRKA9) (A-kinase anchor protein 450 kDa) (AKAP 450) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (AKAP 120-like protein) (Protein hyperion) (Protein yotiao) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP).

RPA2_MOUSE
NC score	0.006308 (rank : 92)	θ value	8.99809 (rank : 82)
Query Neighborhood Hits	84	Target Neighborhood Hits	17	Shared Neighborhood Hits	2
SwissProt Accessions	P70700	Gene names	Polr1b, Rpa2, Rpo1-2
Domain Architecture
Description	DNA-directed RNA polymerase I 135 kDa polypeptide (EC 2.7.7.6) (RNA polymerase I subunit 2) (RPA135).

SPTN5_HUMAN
NC score	0.005140 (rank : 93)	θ value	4.03905 (rank : 73)
Query Neighborhood Hits	84	Target Neighborhood Hits	674	Shared Neighborhood Hits	10
SwissProt Accessions	Q9NRC6	Gene names	SPTBN5, SPTBN4
Domain Architecture
Description	Spectrin beta chain, brain 4 (Spectrin, non-erythroid beta chain 4) (Beta-V spectrin) (BSPECV).

DYHC_HUMAN
NC score	0.005130 (rank : 94)	θ value	6.88961 (rank : 77)
Query Neighborhood Hits	84	Target Neighborhood Hits	733	Shared Neighborhood Hits	10
SwissProt Accessions	Q14204, Q6DKQ7, Q8WU28, Q92814, Q9Y4G5	Gene names	DYNC1H1, DNCH1, DNECL, KIAA0325
Domain Architecture	No domain graphic available
Description	Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain 1) (DHC1) (Dynein heavy chain 1, cytoplasmic 1).

CT2NL_HUMAN
NC score	0.003709 (rank : 95)	θ value	8.99809 (rank : 80)
Query Neighborhood Hits	84	Target Neighborhood Hits	1059	Shared Neighborhood Hits	14
SwissProt Accessions	Q9P2B4, Q96B40	Gene names	CTTNBP2NL, KIAA1433
Domain Architecture	No domain graphic available
Description	CTTNBP2 N-terminal-like protein.

SYNE1_HUMAN
NC score	0.002841 (rank : 96)	θ value	8.99809 (rank : 83)
Query Neighborhood Hits	84	Target Neighborhood Hits	1484	Shared Neighborhood Hits	13
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

ZN306_HUMAN
NC score	-0.004312 (rank : 97)	θ value	8.99809 (rank : 84)
Query Neighborhood Hits	84	Target Neighborhood Hits	757	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BRR0, Q5VXH3, Q92972, Q9H4T3	Gene names	ZNF306, ZFP47, ZSCAN13
Domain Architecture
Description	Zinc finger protein 306 (Zinc finger protein 47 homolog) (Zfp-47) (Zf47) (Zinc finger and SCAN domain-containing protein 13).

NEK1_MOUSE
NC score	-0.004496 (rank : 98)	θ value	8.99809 (rank : 81)
Query Neighborhood Hits	84	Target Neighborhood Hits	1311	Shared Neighborhood Hits	7
SwissProt Accessions	P51954	Gene names	Nek1
Domain Architecture
Description	Serine/threonine-protein kinase Nek1 (EC 2.7.11.1) (NimA-related protein kinase 1).