Please be patient as the page loads

Stop Image Loading/Displaying

Network neighborhood for query Sequence : TRPM2_MOUSE

For an explanation of this page, click here

TRPM2_MOUSE
SwissProt Accessions	Q91YD4	Gene names	Trpm2, Ltrpc2, Trpc7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC2) (LTrpC-2) (Transient receptor potential channel 7) (TrpC7).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

TRPM2_HUMAN
θ value	0 (rank : 1)	NC score	0.996452 (rank : 2)
Query Neighborhood Hits	61	Target Neighborhood Hits	64	Shared Neighborhood Hits	41
SwissProt Accessions	O94759, Q5KTC2, Q6J3P5, Q96KN6, Q96Q93	Gene names	TRPM2, EREG1, KNP3, LTRPC2, TRPC7
Domain Architecture
Description	Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC2) (LTrpC-2) (Transient receptor potential channel 7) (TrpC7) (Estrogen- responsive element-associated gene 1 protein).

TRPM2_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	61	Target Neighborhood Hits	61	Shared Neighborhood Hits	61
SwissProt Accessions	Q91YD4	Gene names	Trpm2, Ltrpc2, Trpc7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC2) (LTrpC-2) (Transient receptor potential channel 7) (TrpC7).

TRPM8_HUMAN
θ value	0 (rank : 3)	NC score	0.935989 (rank : 3)
Query Neighborhood Hits	61	Target Neighborhood Hits	65	Shared Neighborhood Hits	35
SwissProt Accessions	Q7Z2W7, Q6QNH9, Q8TAC3, Q8TDX8, Q9BVK1	Gene names	TRPM8, LTRPC6, TRPP8
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 8 (Transient receptor potential-p8) (Trp-p8) (Long transient receptor potential channel 6) (LTrpC6).

TRPM8_MOUSE
θ value	0 (rank : 4)	NC score	0.934318 (rank : 4)
Query Neighborhood Hits	61	Target Neighborhood Hits	58	Shared Neighborhood Hits	33
SwissProt Accessions	Q8R4D5	Gene names	Trpm8, Trpp8
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 8.

TRPM7_HUMAN
θ value	1.52337e-140 (rank : 5)	NC score	0.861586 (rank : 6)
Query Neighborhood Hits	61	Target Neighborhood Hits	104	Shared Neighborhood Hits	33
SwissProt Accessions	Q96QT4, Q6ZMF5, Q86VJ4, Q8NBW2, Q9BXB2, Q9NXQ2	Gene names	TRPM7, CHAK1, LTRPC7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Long transient receptor potential channel 7) (LTrpC7) (Channel-kinase 1).

TRPM3_HUMAN
θ value	1.42914e-130 (rank : 6)	NC score	0.872066 (rank : 5)
Query Neighborhood Hits	61	Target Neighborhood Hits	121	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HCF6, Q5VW02, Q5VW03, Q5VW04, Q5W5T7, Q86SH0, Q86SH6, Q86UL0, Q86WK1, Q86WK2, Q86WK3, Q86WK4, Q86YZ9, Q86Z00, Q86Z01	Gene names	TRPM3, KIAA1616, LTRPC3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC3) (Melastatin-2) (MLSN2).

TRPM7_MOUSE
θ value	3.9282e-96 (rank : 7)	NC score	0.848246 (rank : 8)
Query Neighborhood Hits	61	Target Neighborhood Hits	113	Shared Neighborhood Hits	33
SwissProt Accessions	Q923J1, Q8C7S7, Q8CE54, Q921Y5, Q925B2, Q9CUT2, Q9JLQ1	Gene names	Trpm7, Chak, Ltrpc7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Long transient receptor potential channel 7) (LTrpC7) (Channel-kinase 1) (Transient receptor potential-phospholipase C- interacting kinase) (TRP-PLIK).

TRPM6_MOUSE
θ value	9.056e-93 (rank : 8)	NC score	0.851060 (rank : 7)
Query Neighborhood Hits	61	Target Neighborhood Hits	78	Shared Neighborhood Hits	30
SwissProt Accessions	Q8CIR4	Gene names	Trpm6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6).

TRPM6_HUMAN
θ value	6.71607e-88 (rank : 9)	NC score	0.845627 (rank : 9)
Query Neighborhood Hits	61	Target Neighborhood Hits	91	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BX84, Q6VPR8, Q6VPR9, Q6VPS0, Q6VPS1, Q6VPS2	Gene names	TRPM6, CHAK2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6).

NUDT9_MOUSE
θ value	3.86705e-35 (rank : 10)	NC score	0.471711 (rank : 12)
Query Neighborhood Hits	61	Target Neighborhood Hits	24	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BVU5, Q3TZ68, Q8K1J4	Gene names	Nudt9
Domain Architecture	No domain graphic available
Description	ADP-ribose pyrophosphatase, mitochondrial precursor (EC 3.6.1.13) (ADP-ribose diphosphatase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (ADP-ribose phosphohydrolase) (Nucleoside diphosphate- linked moiety X motif 9) (Nudix motif 9).

NUDT9_HUMAN
θ value	5.0505e-35 (rank : 11)	NC score	0.471320 (rank : 13)
Query Neighborhood Hits	61	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BW91, Q8NBN1, Q8NCB9, Q8NG25	Gene names	NUDT9, NUDT10
Domain Architecture
Description	ADP-ribose pyrophosphatase, mitochondrial precursor (EC 3.6.1.13) (ADP-ribose diphosphatase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (ADP-ribose phosphohydrolase) (Nucleoside diphosphate- linked moiety X motif 9) (Nudix motif 9).

TRPC4_HUMAN
θ value	4.91457e-14 (rank : 12)	NC score	0.479442 (rank : 10)
Query Neighborhood Hits	61	Target Neighborhood Hits	140	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UBN4, Q15721, Q9UIB0, Q9UIB1, Q9UIB2	Gene names	TRPC4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (trp-related protein 4) (hTrp-4) (hTrp4).

TRPC4_MOUSE
θ value	1.86753e-13 (rank : 13)	NC score	0.478059 (rank : 11)
Query Neighborhood Hits	61	Target Neighborhood Hits	141	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QUQ5, Q62350, Q9QUQ9, Q9QZC0	Gene names	Trpc4, Trrp4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (Receptor- activated cation channel TRP4) (Capacitative calcium entry channel Trp4).

TRPC5_HUMAN
θ value	9.26847e-13 (rank : 14)	NC score	0.466929 (rank : 15)
Query Neighborhood Hits	61	Target Neighborhood Hits	122	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UL62, O75233, Q5JXY8, Q9Y514	Gene names	TRPC5, TRP5
Domain Architecture
Description	Short transient receptor potential channel 5 (TrpC5) (Htrp-5) (Htrp5).

TRPC5_MOUSE
θ value	9.26847e-13 (rank : 15)	NC score	0.467031 (rank : 14)
Query Neighborhood Hits	61	Target Neighborhood Hits	124	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QX29, Q61059, Q9QWT1, Q9R0D4	Gene names	Trpc5, Trp5, Trrp5
Domain Architecture
Description	Short transient receptor potential channel 5 (TrpC5) (Transient receptor protein 5) (Mtrp5) (trp-related protein 5) (Capacitative calcium entry channel 2) (CCE2).

TRPC3_HUMAN
θ value	1.33837e-11 (rank : 16)	NC score	0.393677 (rank : 19)
Query Neighborhood Hits	61	Target Neighborhood Hits	137	Shared Neighborhood Hits	33
SwissProt Accessions	Q13507, O00593, Q15660	Gene names	TRPC3, TRP3
Domain Architecture
Description	Short transient receptor potential channel 3 (TrpC3) (Htrp-3) (Htrp3).

TRPC3_MOUSE
θ value	1.133e-10 (rank : 17)	NC score	0.398753 (rank : 18)
Query Neighborhood Hits	61	Target Neighborhood Hits	131	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QZC1, Q61058	Gene names	Trpc3, Trp3, Trrp3
Domain Architecture
Description	Short transient receptor potential channel 3 (TrpC3) (Transient receptor protein 3) (Mtrp3) (Receptor-activated cation channel TRP3) (trp-related protein 3).

NUD9P_HUMAN
θ value	4.30538e-10 (rank : 18)	NC score	0.405686 (rank : 17)
Query Neighborhood Hits	61	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N2Z3	Gene names	NUDT9P1, C10orf98
Domain Architecture	No domain graphic available
Description	Putative nucleoside diphosphate-linked moiety X motif 9P1.

TRPC1_HUMAN
θ value	1.69304e-06 (rank : 19)	NC score	0.364177 (rank : 21)
Query Neighborhood Hits	61	Target Neighborhood Hits	91	Shared Neighborhood Hits	33
SwissProt Accessions	P48995	Gene names	TRPC1, TRP1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (TRP-1 protein).

TRPC1_MOUSE
θ value	1.69304e-06 (rank : 20)	NC score	0.364505 (rank : 20)
Query Neighborhood Hits	61	Target Neighborhood Hits	87	Shared Neighborhood Hits	33
SwissProt Accessions	Q61056, O35722	Gene names	Trpc1, Trp1, Trrp1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (Mtrp1) (Trp-related protein 1).

TRPV4_HUMAN
θ value	3.19293e-05 (rank : 21)	NC score	0.199856 (rank : 28)
Query Neighborhood Hits	61	Target Neighborhood Hits	150	Shared Neighborhood Hits	34
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TRPC2_MOUSE
θ value	7.1131e-05 (rank : 22)	NC score	0.414491 (rank : 16)
Query Neighborhood Hits	61	Target Neighborhood Hits	84	Shared Neighborhood Hits	32
SwissProt Accessions	Q9R244, Q9ES59, Q9ES60, Q9R243	Gene names	Trpc2, Trp2, Trrp2
Domain Architecture
Description	Short transient receptor potential channel 2 (TrpC2) (mTrp2).

TRPV3_HUMAN
θ value	0.00020696 (rank : 23)	NC score	0.256853 (rank : 26)
Query Neighborhood Hits	61	Target Neighborhood Hits	198	Shared Neighborhood Hits	38
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

TRPV3_MOUSE
θ value	0.000270298 (rank : 24)	NC score	0.253315 (rank : 27)
Query Neighborhood Hits	61	Target Neighborhood Hits	188	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

TRPC6_HUMAN
θ value	0.00175202 (rank : 25)	NC score	0.351729 (rank : 23)
Query Neighborhood Hits	61	Target Neighborhood Hits	171	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Y210, Q9HCW3, Q9NQA8, Q9NQA9	Gene names	TRPC6, TRP6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6).

TRPC6_MOUSE
θ value	0.00175202 (rank : 26)	NC score	0.354070 (rank : 22)
Query Neighborhood Hits	61	Target Neighborhood Hits	171	Shared Neighborhood Hits	33
SwissProt Accessions	Q61143, Q9Z2J1	Gene names	Trpc6, Trp6, Trrp6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6) (Calcium entry channel).

TRPV6_HUMAN
θ value	0.00390308 (rank : 27)	NC score	0.175179 (rank : 32)
Query Neighborhood Hits	61	Target Neighborhood Hits	262	Shared Neighborhood Hits	33
SwissProt Accessions	Q9H1D0, Q8TDL3, Q8WXR8, Q96LC5, Q9H1D1, Q9H296	Gene names	TRPV6, ECAC2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1) (CaT-like) (CaT-L).

TRPV1_HUMAN
θ value	0.00869519 (rank : 28)	NC score	0.197795 (rank : 29)
Query Neighborhood Hits	61	Target Neighborhood Hits	184	Shared Neighborhood Hits	34
SwissProt Accessions	Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22	Gene names	TRPV1, VR1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Capsaicin receptor).

TRPV1_MOUSE
θ value	0.00869519 (rank : 29)	NC score	0.192866 (rank : 30)
Query Neighborhood Hits	61	Target Neighborhood Hits	189	Shared Neighborhood Hits	34
SwissProt Accessions	Q704Y3, Q5SSE1, Q5SSE2, Q5SSE4, Q5WPV5, Q68SW0	Gene names	Trpv1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1).

TRPC7_HUMAN
θ value	0.0148317 (rank : 30)	NC score	0.343545 (rank : 25)
Query Neighborhood Hits	61	Target Neighborhood Hits	123	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HCX4	Gene names	TRPC7, TRP7
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (TRP7 protein).

TRPV4_MOUSE
θ value	0.0252991 (rank : 31)	NC score	0.180234 (rank : 31)
Query Neighborhood Hits	61	Target Neighborhood Hits	117	Shared Neighborhood Hits	34
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TRPC7_MOUSE
θ value	0.0330416 (rank : 32)	NC score	0.344647 (rank : 24)
Query Neighborhood Hits	61	Target Neighborhood Hits	114	Shared Neighborhood Hits	34
SwissProt Accessions	Q9WVC5	Gene names	Trpc7, Trp7, Trrp8
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (mTRP7).

TRPV6_MOUSE
θ value	0.0330416 (rank : 33)	NC score	0.159218 (rank : 33)
Query Neighborhood Hits	61	Target Neighborhood Hits	284	Shared Neighborhood Hits	33
SwissProt Accessions	Q91WD2	Gene names	Trpv6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1).

TRPV5_MOUSE
θ value	0.365318 (rank : 34)	NC score	0.144980 (rank : 36)
Query Neighborhood Hits	61	Target Neighborhood Hits	278	Shared Neighborhood Hits	32
SwissProt Accessions	P69744	Gene names	Trpv5
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC1) (Calcium transport protein 2) (CaT2).

ROCK2_HUMAN
θ value	0.62314 (rank : 35)	NC score	-0.000323 (rank : 68)
Query Neighborhood Hits	61	Target Neighborhood Hits	2073	Shared Neighborhood Hits	12
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).

CAC1G_HUMAN
θ value	0.813845 (rank : 36)	NC score	0.021783 (rank : 47)
Query Neighborhood Hits	61	Target Neighborhood Hits	587	Shared Neighborhood Hits	11
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

CCD46_HUMAN
θ value	0.813845 (rank : 37)	NC score	0.004995 (rank : 59)
Query Neighborhood Hits	61	Target Neighborhood Hits	1430	Shared Neighborhood Hits	13
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

TRPV5_HUMAN
θ value	0.813845 (rank : 38)	NC score	0.150402 (rank : 34)
Query Neighborhood Hits	61	Target Neighborhood Hits	261	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NQA5, Q8NDW5, Q8NDX7, Q8NDX8, Q96PM6	Gene names	TRPV5, ECAC1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Calcium transport protein 2) (CaT2).

CAC1I_HUMAN
θ value	1.06291 (rank : 39)	NC score	0.021989 (rank : 46)
Query Neighborhood Hits	61	Target Neighborhood Hits	138	Shared Neighborhood Hits	9
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

BAK_MOUSE
θ value	1.81305 (rank : 40)	NC score	0.016813 (rank : 52)
Query Neighborhood Hits	61	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	O08734	Gene names	Bak1, Bak
Domain Architecture
Description	Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK).

MCM8_MOUSE
θ value	1.81305 (rank : 41)	NC score	0.015112 (rank : 53)
Query Neighborhood Hits	61	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CWV1, Q80US2, Q80VI0	Gene names	Mcm8
Domain Architecture	No domain graphic available
Description	DNA replication licensing factor MCM8 (Minichromosome maintenance 8).

CCD42_MOUSE
θ value	2.36792 (rank : 42)	NC score	0.025202 (rank : 44)
Query Neighborhood Hits	61	Target Neighborhood Hits	284	Shared Neighborhood Hits	8
SwissProt Accessions	Q5SV66, Q8BNY1	Gene names	Ccdc42
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 42.

FA62A_MOUSE
θ value	2.36792 (rank : 43)	NC score	0.009714 (rank : 57)
Query Neighborhood Hits	61	Target Neighborhood Hits	155	Shared Neighborhood Hits	2
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

MCM8_HUMAN
θ value	2.36792 (rank : 44)	NC score	0.014578 (rank : 54)
Query Neighborhood Hits	61	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UJA3, Q495R4, Q495R7, Q86US4, Q969I5	Gene names	MCM8, C20orf154
Domain Architecture
Description	DNA replication licensing factor MCM8 (Minichromosome maintenance 8).

SYNE1_HUMAN
θ value	3.0926 (rank : 45)	NC score	0.008896 (rank : 58)
Query Neighborhood Hits	61	Target Neighborhood Hits	1484	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

CAC1H_HUMAN
θ value	4.03905 (rank : 46)	NC score	0.017143 (rank : 50)
Query Neighborhood Hits	61	Target Neighborhood Hits	307	Shared Neighborhood Hits	12
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

MCES_MOUSE
θ value	4.03905 (rank : 47)	NC score	0.014209 (rank : 55)
Query Neighborhood Hits	61	Target Neighborhood Hits	88	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D0L8, Q3V3U9, Q6ZQC6, Q9D5F1	Gene names	Rnmt, Kiaa0398
Domain Architecture	No domain graphic available
Description	mRNA cap guanine-N7 methyltransferase (EC 2.1.1.56) (mRNA (guanine- N(7)-)-methyltransferase) (RG7MT1) (mRNA cap methyltransferase).

DISC1_HUMAN
θ value	5.27518 (rank : 48)	NC score	0.011658 (rank : 56)
Query Neighborhood Hits	61	Target Neighborhood Hits	199	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NRI5, O75045, Q5VT44, Q5VT45, Q8IXJ0, Q8IXJ1, Q9BX19, Q9NRI3, Q9NRI4	Gene names	DISC1, KIAA0457
Domain Architecture	No domain graphic available
Description	Disrupted in schizophrenia 1 protein.

PKD2_HUMAN
θ value	5.27518 (rank : 49)	NC score	0.049772 (rank : 43)
Query Neighborhood Hits	61	Target Neighborhood Hits	105	Shared Neighborhood Hits	27
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

SC10A_MOUSE
θ value	5.27518 (rank : 50)	NC score	0.022715 (rank : 45)
Query Neighborhood Hits	61	Target Neighborhood Hits	107	Shared Neighborhood Hits	20
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

SCN4A_HUMAN
θ value	5.27518 (rank : 51)	NC score	0.016905 (rank : 51)
Query Neighborhood Hits	61	Target Neighborhood Hits	133	Shared Neighborhood Hits	18
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

SDCG8_HUMAN
θ value	5.27518 (rank : 52)	NC score	0.003984 (rank : 61)
Query Neighborhood Hits	61	Target Neighborhood Hits	1002	Shared Neighborhood Hits	10
SwissProt Accessions	Q86SQ7, O60527, Q3ZCR6, Q8N5F2, Q9P0F1	Gene names	SDCCAG8, CCCAP
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (hCCCAP) (Antigen NY-CO-8).

HMMR_MOUSE
θ value	6.88961 (rank : 53)	NC score	0.002105 (rank : 65)
Query Neighborhood Hits	61	Target Neighborhood Hits	1178	Shared Neighborhood Hits	11
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

MAP1A_HUMAN
θ value	6.88961 (rank : 54)	NC score	0.002330 (rank : 64)
Query Neighborhood Hits	61	Target Neighborhood Hits	1626	Shared Neighborhood Hits	10
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

MYOM1_HUMAN
θ value	6.88961 (rank : 55)	NC score	0.002356 (rank : 63)
Query Neighborhood Hits	61	Target Neighborhood Hits	405	Shared Neighborhood Hits	3
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

NUDT6_MOUSE
θ value	6.88961 (rank : 56)	NC score	0.018535 (rank : 49)
Query Neighborhood Hits	61	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CH40, Q8R2T3	Gene names	Nudt6, Asfgf2b
Domain Architecture	No domain graphic available
Description	Nucleoside diphosphate-linked moiety X motif 6 (Nudix motif 6) (Antisense basic fibroblast growth factor B).

SCN7A_HUMAN
θ value	6.88961 (rank : 57)	NC score	0.019774 (rank : 48)
Query Neighborhood Hits	61	Target Neighborhood Hits	135	Shared Neighborhood Hits	13
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

CASP_MOUSE
θ value	8.99809 (rank : 58)	NC score	0.004660 (rank : 60)
Query Neighborhood Hits	61	Target Neighborhood Hits	1152	Shared Neighborhood Hits	14
SwissProt Accessions	P70403, Q7TQJ4, Q91WN6	Gene names	Cutl1
Domain Architecture	No domain graphic available
Description	Protein CASP.

CUTL1_MOUSE
θ value	8.99809 (rank : 59)	NC score	0.003966 (rank : 62)
Query Neighborhood Hits	61	Target Neighborhood Hits	1620	Shared Neighborhood Hits	15
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

IGS4B_HUMAN
θ value	8.99809 (rank : 60)	NC score	0.001896 (rank : 66)
Query Neighborhood Hits	61	Target Neighborhood Hits	305	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N126, Q9NVJ5, Q9UJP1	Gene names	IGSF4B, NECL1, SYNCAM3, TSLL1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3) (Brain immunoglobulin receptor).

LAMC3_MOUSE
θ value	8.99809 (rank : 61)	NC score	0.000595 (rank : 67)
Query Neighborhood Hits	61	Target Neighborhood Hits	624	Shared Neighborhood Hits	7
SwissProt Accessions	Q9R0B6, Q9WTW6	Gene names	Lamc3
Domain Architecture
Description	Laminin gamma-3 chain precursor (Laminin 12 gamma 3 subunit).

EF2K_HUMAN
θ value	θ > 10 (rank : 62)	NC score	0.140781 (rank : 37)
Query Neighborhood Hits	61	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	O00418	Gene names	EEF2K
Domain Architecture
Description	Elongation factor 2 kinase (EC 2.7.11.20) (eEF-2 kinase) (eEF-2K) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase).

EF2K_MOUSE
θ value	θ > 10 (rank : 63)	NC score	0.146298 (rank : 35)
Query Neighborhood Hits	61	Target Neighborhood Hits	33	Shared Neighborhood Hits	4
SwissProt Accessions	O08796	Gene names	Eef2k
Domain Architecture
Description	Elongation factor 2 kinase (EC 2.7.11.20) (eEF-2 kinase) (eEF-2K) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase).

PK2L1_HUMAN
θ value	θ > 10 (rank : 64)	NC score	0.091852 (rank : 40)
Query Neighborhood Hits	61	Target Neighborhood Hits	132	Shared Neighborhood Hits	32
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

PK2L2_HUMAN
θ value	θ > 10 (rank : 65)	NC score	0.057117 (rank : 42)
Query Neighborhood Hits	61	Target Neighborhood Hits	90	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PK2L2_MOUSE
θ value	θ > 10 (rank : 66)	NC score	0.062254 (rank : 41)
Query Neighborhood Hits	61	Target Neighborhood Hits	84	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

TRPV2_HUMAN
θ value	θ > 10 (rank : 67)	NC score	0.122259 (rank : 39)
Query Neighborhood Hits	61	Target Neighborhood Hits	130	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y5S1, Q9Y670	Gene names	TRPV2, VRL
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1).

TRPV2_MOUSE
θ value	θ > 10 (rank : 68)	NC score	0.138853 (rank : 38)
Query Neighborhood Hits	61	Target Neighborhood Hits	111	Shared Neighborhood Hits	21
SwissProt Accessions	Q9WTR1, Q99K71	Gene names	Trpv2, Grc
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Growth factor-regulated calcium channel) (GRC).

Hits sorted by NC score

TRPM2_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	61	Target Neighborhood Hits	61	Shared Neighborhood Hits	61
SwissProt Accessions	Q91YD4	Gene names	Trpm2, Ltrpc2, Trpc7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC2) (LTrpC-2) (Transient receptor potential channel 7) (TrpC7).

TRPM2_HUMAN
NC score	0.996452 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	61	Target Neighborhood Hits	64	Shared Neighborhood Hits	41
SwissProt Accessions	O94759, Q5KTC2, Q6J3P5, Q96KN6, Q96Q93	Gene names	TRPM2, EREG1, KNP3, LTRPC2, TRPC7
Domain Architecture
Description	Transient receptor potential cation channel subfamily M member 2 (EC 3.6.1.13) (Long transient receptor potential channel 2) (LTrpC2) (LTrpC-2) (Transient receptor potential channel 7) (TrpC7) (Estrogen- responsive element-associated gene 1 protein).

TRPM8_HUMAN
NC score	0.935989 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	61	Target Neighborhood Hits	65	Shared Neighborhood Hits	35
SwissProt Accessions	Q7Z2W7, Q6QNH9, Q8TAC3, Q8TDX8, Q9BVK1	Gene names	TRPM8, LTRPC6, TRPP8
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 8 (Transient receptor potential-p8) (Trp-p8) (Long transient receptor potential channel 6) (LTrpC6).

TRPM8_MOUSE
NC score	0.934318 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	61	Target Neighborhood Hits	58	Shared Neighborhood Hits	33
SwissProt Accessions	Q8R4D5	Gene names	Trpm8, Trpp8
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 8.

TRPM3_HUMAN
NC score	0.872066 (rank : 5)	θ value	1.42914e-130 (rank : 6)
Query Neighborhood Hits	61	Target Neighborhood Hits	121	Shared Neighborhood Hits	32
SwissProt Accessions	Q9HCF6, Q5VW02, Q5VW03, Q5VW04, Q5W5T7, Q86SH0, Q86SH6, Q86UL0, Q86WK1, Q86WK2, Q86WK3, Q86WK4, Q86YZ9, Q86Z00, Q86Z01	Gene names	TRPM3, KIAA1616, LTRPC3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 3 (Long transient receptor potential channel 3) (LTrpC3) (Melastatin-2) (MLSN2).

TRPM7_HUMAN
NC score	0.861586 (rank : 6)	θ value	1.52337e-140 (rank : 5)
Query Neighborhood Hits	61	Target Neighborhood Hits	104	Shared Neighborhood Hits	33
SwissProt Accessions	Q96QT4, Q6ZMF5, Q86VJ4, Q8NBW2, Q9BXB2, Q9NXQ2	Gene names	TRPM7, CHAK1, LTRPC7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Long transient receptor potential channel 7) (LTrpC7) (Channel-kinase 1).

TRPM6_MOUSE
NC score	0.851060 (rank : 7)	θ value	9.056e-93 (rank : 8)
Query Neighborhood Hits	61	Target Neighborhood Hits	78	Shared Neighborhood Hits	30
SwissProt Accessions	Q8CIR4	Gene names	Trpm6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6).

TRPM7_MOUSE
NC score	0.848246 (rank : 8)	θ value	3.9282e-96 (rank : 7)
Query Neighborhood Hits	61	Target Neighborhood Hits	113	Shared Neighborhood Hits	33
SwissProt Accessions	Q923J1, Q8C7S7, Q8CE54, Q921Y5, Q925B2, Q9CUT2, Q9JLQ1	Gene names	Trpm7, Chak, Ltrpc7
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 7 (EC 2.7.11.1) (Long transient receptor potential channel 7) (LTrpC7) (Channel-kinase 1) (Transient receptor potential-phospholipase C- interacting kinase) (TRP-PLIK).

TRPM6_HUMAN
NC score	0.845627 (rank : 9)	θ value	6.71607e-88 (rank : 9)
Query Neighborhood Hits	61	Target Neighborhood Hits	91	Shared Neighborhood Hits	32
SwissProt Accessions	Q9BX84, Q6VPR8, Q6VPR9, Q6VPS0, Q6VPS1, Q6VPS2	Gene names	TRPM6, CHAK2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily M member 6 (EC 2.7.11.1) (Channel kinase 2) (Melastatin-related TRP cation channel 6).

TRPC4_HUMAN
NC score	0.479442 (rank : 10)	θ value	4.91457e-14 (rank : 12)
Query Neighborhood Hits	61	Target Neighborhood Hits	140	Shared Neighborhood Hits	37
SwissProt Accessions	Q9UBN4, Q15721, Q9UIB0, Q9UIB1, Q9UIB2	Gene names	TRPC4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (trp-related protein 4) (hTrp-4) (hTrp4).

TRPC4_MOUSE
NC score	0.478059 (rank : 11)	θ value	1.86753e-13 (rank : 13)
Query Neighborhood Hits	61	Target Neighborhood Hits	141	Shared Neighborhood Hits	36
SwissProt Accessions	Q9QUQ5, Q62350, Q9QUQ9, Q9QZC0	Gene names	Trpc4, Trrp4
Domain Architecture
Description	Short transient receptor potential channel 4 (TrpC4) (Receptor- activated cation channel TRP4) (Capacitative calcium entry channel Trp4).

NUDT9_MOUSE
NC score	0.471711 (rank : 12)	θ value	3.86705e-35 (rank : 10)
Query Neighborhood Hits	61	Target Neighborhood Hits	24	Shared Neighborhood Hits	6
SwissProt Accessions	Q8BVU5, Q3TZ68, Q8K1J4	Gene names	Nudt9
Domain Architecture	No domain graphic available
Description	ADP-ribose pyrophosphatase, mitochondrial precursor (EC 3.6.1.13) (ADP-ribose diphosphatase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (ADP-ribose phosphohydrolase) (Nucleoside diphosphate- linked moiety X motif 9) (Nudix motif 9).

NUDT9_HUMAN
NC score	0.471320 (rank : 13)	θ value	5.0505e-35 (rank : 11)
Query Neighborhood Hits	61	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BW91, Q8NBN1, Q8NCB9, Q8NG25	Gene names	NUDT9, NUDT10
Domain Architecture
Description	ADP-ribose pyrophosphatase, mitochondrial precursor (EC 3.6.1.13) (ADP-ribose diphosphatase) (Adenosine diphosphoribose pyrophosphatase) (ADPR-PPase) (ADP-ribose phosphohydrolase) (Nucleoside diphosphate- linked moiety X motif 9) (Nudix motif 9).

TRPC5_MOUSE
NC score	0.467031 (rank : 14)	θ value	9.26847e-13 (rank : 15)
Query Neighborhood Hits	61	Target Neighborhood Hits	124	Shared Neighborhood Hits	35
SwissProt Accessions	Q9QX29, Q61059, Q9QWT1, Q9R0D4	Gene names	Trpc5, Trp5, Trrp5
Domain Architecture
Description	Short transient receptor potential channel 5 (TrpC5) (Transient receptor protein 5) (Mtrp5) (trp-related protein 5) (Capacitative calcium entry channel 2) (CCE2).

TRPC5_HUMAN
NC score	0.466929 (rank : 15)	θ value	9.26847e-13 (rank : 14)
Query Neighborhood Hits	61	Target Neighborhood Hits	122	Shared Neighborhood Hits	35
SwissProt Accessions	Q9UL62, O75233, Q5JXY8, Q9Y514	Gene names	TRPC5, TRP5
Domain Architecture
Description	Short transient receptor potential channel 5 (TrpC5) (Htrp-5) (Htrp5).

TRPC2_MOUSE
NC score	0.414491 (rank : 16)	θ value	7.1131e-05 (rank : 22)
Query Neighborhood Hits	61	Target Neighborhood Hits	84	Shared Neighborhood Hits	32
SwissProt Accessions	Q9R244, Q9ES59, Q9ES60, Q9R243	Gene names	Trpc2, Trp2, Trrp2
Domain Architecture
Description	Short transient receptor potential channel 2 (TrpC2) (mTrp2).

NUD9P_HUMAN
NC score	0.405686 (rank : 17)	θ value	4.30538e-10 (rank : 18)
Query Neighborhood Hits	61	Target Neighborhood Hits	12	Shared Neighborhood Hits	6
SwissProt Accessions	Q8N2Z3	Gene names	NUDT9P1, C10orf98
Domain Architecture	No domain graphic available
Description	Putative nucleoside diphosphate-linked moiety X motif 9P1.

TRPC3_MOUSE
NC score	0.398753 (rank : 18)	θ value	1.133e-10 (rank : 17)
Query Neighborhood Hits	61	Target Neighborhood Hits	131	Shared Neighborhood Hits	33
SwissProt Accessions	Q9QZC1, Q61058	Gene names	Trpc3, Trp3, Trrp3
Domain Architecture
Description	Short transient receptor potential channel 3 (TrpC3) (Transient receptor protein 3) (Mtrp3) (Receptor-activated cation channel TRP3) (trp-related protein 3).

TRPC3_HUMAN
NC score	0.393677 (rank : 19)	θ value	1.33837e-11 (rank : 16)
Query Neighborhood Hits	61	Target Neighborhood Hits	137	Shared Neighborhood Hits	33
SwissProt Accessions	Q13507, O00593, Q15660	Gene names	TRPC3, TRP3
Domain Architecture
Description	Short transient receptor potential channel 3 (TrpC3) (Htrp-3) (Htrp3).

TRPC1_MOUSE
NC score	0.364505 (rank : 20)	θ value	1.69304e-06 (rank : 20)
Query Neighborhood Hits	61	Target Neighborhood Hits	87	Shared Neighborhood Hits	33
SwissProt Accessions	Q61056, O35722	Gene names	Trpc1, Trp1, Trrp1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (Mtrp1) (Trp-related protein 1).

TRPC1_HUMAN
NC score	0.364177 (rank : 21)	θ value	1.69304e-06 (rank : 19)
Query Neighborhood Hits	61	Target Neighborhood Hits	91	Shared Neighborhood Hits	33
SwissProt Accessions	P48995	Gene names	TRPC1, TRP1
Domain Architecture
Description	Short transient receptor potential channel 1 (TrpC1) (TRP-1 protein).

TRPC6_MOUSE
NC score	0.354070 (rank : 22)	θ value	0.00175202 (rank : 26)
Query Neighborhood Hits	61	Target Neighborhood Hits	171	Shared Neighborhood Hits	33
SwissProt Accessions	Q61143, Q9Z2J1	Gene names	Trpc6, Trp6, Trrp6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6) (Calcium entry channel).

TRPC6_HUMAN
NC score	0.351729 (rank : 23)	θ value	0.00175202 (rank : 25)
Query Neighborhood Hits	61	Target Neighborhood Hits	171	Shared Neighborhood Hits	34
SwissProt Accessions	Q9Y210, Q9HCW3, Q9NQA8, Q9NQA9	Gene names	TRPC6, TRP6
Domain Architecture
Description	Short transient receptor potential channel 6 (TrpC6).

TRPC7_MOUSE
NC score	0.344647 (rank : 24)	θ value	0.0330416 (rank : 32)
Query Neighborhood Hits	61	Target Neighborhood Hits	114	Shared Neighborhood Hits	34
SwissProt Accessions	Q9WVC5	Gene names	Trpc7, Trp7, Trrp8
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (mTRP7).

TRPC7_HUMAN
NC score	0.343545 (rank : 25)	θ value	0.0148317 (rank : 30)
Query Neighborhood Hits	61	Target Neighborhood Hits	123	Shared Neighborhood Hits	35
SwissProt Accessions	Q9HCX4	Gene names	TRPC7, TRP7
Domain Architecture
Description	Short transient receptor potential channel 7 (TrpC7) (TRP7 protein).

TRPV3_HUMAN
NC score	0.256853 (rank : 26)	θ value	0.00020696 (rank : 23)
Query Neighborhood Hits	61	Target Neighborhood Hits	198	Shared Neighborhood Hits	38
SwissProt Accessions	Q8NET8, Q8NDW7, Q8NET9, Q8NFH2	Gene names	TRPV3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3) (Vanilloid receptor-like 3) (VRL-3).

TRPV3_MOUSE
NC score	0.253315 (rank : 27)	θ value	0.000270298 (rank : 24)
Query Neighborhood Hits	61	Target Neighborhood Hits	188	Shared Neighborhood Hits	35
SwissProt Accessions	Q8K424, Q5SV08	Gene names	Trpv3
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 3 (TrpV3).

TRPV4_HUMAN
NC score	0.199856 (rank : 28)	θ value	3.19293e-05 (rank : 21)
Query Neighborhood Hits	61	Target Neighborhood Hits	150	Shared Neighborhood Hits	34
SwissProt Accessions	Q9HBA0, Q86YZ6, Q8NDY7, Q8NG64, Q96Q92, Q96RS7, Q9HBC0	Gene names	TRPV4, VRL2, VROAC
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (VRL-2) (Vanilloid receptor-related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TRPV1_HUMAN
NC score	0.197795 (rank : 29)	θ value	0.00869519 (rank : 28)
Query Neighborhood Hits	61	Target Neighborhood Hits	184	Shared Neighborhood Hits	34
SwissProt Accessions	Q8NER1, Q9H0G9, Q9H303, Q9H304, Q9NQ74, Q9NY22	Gene names	TRPV1, VR1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1) (Capsaicin receptor).

TRPV1_MOUSE
NC score	0.192866 (rank : 30)	θ value	0.00869519 (rank : 29)
Query Neighborhood Hits	61	Target Neighborhood Hits	189	Shared Neighborhood Hits	34
SwissProt Accessions	Q704Y3, Q5SSE1, Q5SSE2, Q5SSE4, Q5WPV5, Q68SW0	Gene names	Trpv1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 1 (TrpV1) (osm-9-like TRP channel 1) (OTRPC1) (Vanilloid receptor 1).

TRPV4_MOUSE
NC score	0.180234 (rank : 31)	θ value	0.0252991 (rank : 31)
Query Neighborhood Hits	61	Target Neighborhood Hits	117	Shared Neighborhood Hits	34
SwissProt Accessions	Q9EPK8, Q91XR5, Q9EQZ4, Q9ERZ7, Q9ES76	Gene names	Trpv4, Trp12, Vrl2, Vroac
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 4 (TrpV4) (osm-9-like TRP channel 4) (OTRPC4) (Vanilloid receptor-like channel 2) (Vanilloid receptor-like protein 2) (Vanilloid receptor- related osmotically-activated channel) (VR-OAC) (Transient receptor potential protein 12) (TRP12).

TRPV6_HUMAN
NC score	0.175179 (rank : 32)	θ value	0.00390308 (rank : 27)
Query Neighborhood Hits	61	Target Neighborhood Hits	262	Shared Neighborhood Hits	33
SwissProt Accessions	Q9H1D0, Q8TDL3, Q8WXR8, Q96LC5, Q9H1D1, Q9H296	Gene names	TRPV6, ECAC2
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1) (CaT-like) (CaT-L).

TRPV6_MOUSE
NC score	0.159218 (rank : 33)	θ value	0.0330416 (rank : 33)
Query Neighborhood Hits	61	Target Neighborhood Hits	284	Shared Neighborhood Hits	33
SwissProt Accessions	Q91WD2	Gene names	Trpv6
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 6 (TrpV6) (Epithelial calcium channel 2) (ECaC2) (Calcium transport protein 1) (CaT1).

TRPV5_HUMAN
NC score	0.150402 (rank : 34)	θ value	0.813845 (rank : 38)
Query Neighborhood Hits	61	Target Neighborhood Hits	261	Shared Neighborhood Hits	32
SwissProt Accessions	Q9NQA5, Q8NDW5, Q8NDX7, Q8NDX8, Q96PM6	Gene names	TRPV5, ECAC1
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC) (ECaC1) (Calcium transport protein 2) (CaT2).

EF2K_MOUSE
NC score	0.146298 (rank : 35)	θ value	θ > 10 (rank : 63)
Query Neighborhood Hits	61	Target Neighborhood Hits	33	Shared Neighborhood Hits	4
SwissProt Accessions	O08796	Gene names	Eef2k
Domain Architecture
Description	Elongation factor 2 kinase (EC 2.7.11.20) (eEF-2 kinase) (eEF-2K) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase).

TRPV5_MOUSE
NC score	0.144980 (rank : 36)	θ value	0.365318 (rank : 34)
Query Neighborhood Hits	61	Target Neighborhood Hits	278	Shared Neighborhood Hits	32
SwissProt Accessions	P69744	Gene names	Trpv5
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 5 (TrpV5) (osm-9-like TRP channel 3) (OTRPC3) (Epithelial calcium channel 1) (ECaC1) (Calcium transport protein 2) (CaT2).

EF2K_HUMAN
NC score	0.140781 (rank : 37)	θ value	θ > 10 (rank : 62)
Query Neighborhood Hits	61	Target Neighborhood Hits	32	Shared Neighborhood Hits	4
SwissProt Accessions	O00418	Gene names	EEF2K
Domain Architecture
Description	Elongation factor 2 kinase (EC 2.7.11.20) (eEF-2 kinase) (eEF-2K) (Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase).

TRPV2_MOUSE
NC score	0.138853 (rank : 38)	θ value	θ > 10 (rank : 68)
Query Neighborhood Hits	61	Target Neighborhood Hits	111	Shared Neighborhood Hits	21
SwissProt Accessions	Q9WTR1, Q99K71	Gene names	Trpv2, Grc
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Growth factor-regulated calcium channel) (GRC).

TRPV2_HUMAN
NC score	0.122259 (rank : 39)	θ value	θ > 10 (rank : 67)
Query Neighborhood Hits	61	Target Neighborhood Hits	130	Shared Neighborhood Hits	18
SwissProt Accessions	Q9Y5S1, Q9Y670	Gene names	TRPV2, VRL
Domain Architecture	No domain graphic available
Description	Transient receptor potential cation channel subfamily V member 2 (TrpV2) (osm-9-like TRP channel 2) (OTRPC2) (Vanilloid receptor-like protein 1) (VRL-1).

PK2L1_HUMAN
NC score	0.091852 (rank : 40)	θ value	θ > 10 (rank : 64)
Query Neighborhood Hits	61	Target Neighborhood Hits	132	Shared Neighborhood Hits	32
SwissProt Accessions	Q9P0L9, O75972, Q9UP35, Q9UPA2	Gene names	PKD2L1, PKD2L, PKDL
Domain Architecture
Description	Polycystic kidney disease 2-like 1 protein (Polycystin-L) (Polycystin- 2 homolog).

PK2L2_MOUSE
NC score	0.062254 (rank : 41)	θ value	θ > 10 (rank : 66)
Query Neighborhood Hits	61	Target Neighborhood Hits	84	Shared Neighborhood Hits	26
SwissProt Accessions	Q9JLG4	Gene names	Pkd2l2
Domain Architecture
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PK2L2_HUMAN
NC score	0.057117 (rank : 42)	θ value	θ > 10 (rank : 65)
Query Neighborhood Hits	61	Target Neighborhood Hits	90	Shared Neighborhood Hits	25
SwissProt Accessions	Q9NZM6, Q9UNJ0	Gene names	PKD2L2
Domain Architecture	No domain graphic available
Description	Polycystic kidney disease 2-like 2 protein (Polycystin-L2).

PKD2_HUMAN
NC score	0.049772 (rank : 43)	θ value	5.27518 (rank : 49)
Query Neighborhood Hits	61	Target Neighborhood Hits	105	Shared Neighborhood Hits	27
SwissProt Accessions	Q13563, O60441, Q15764	Gene names	PKD2
Domain Architecture
Description	Polycystin-2 (Polycystic kidney disease 2 protein homolog) (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321).

CCD42_MOUSE
NC score	0.025202 (rank : 44)	θ value	2.36792 (rank : 42)
Query Neighborhood Hits	61	Target Neighborhood Hits	284	Shared Neighborhood Hits	8
SwissProt Accessions	Q5SV66, Q8BNY1	Gene names	Ccdc42
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 42.

SC10A_MOUSE
NC score	0.022715 (rank : 45)	θ value	5.27518 (rank : 50)
Query Neighborhood Hits	61	Target Neighborhood Hits	107	Shared Neighborhood Hits	20
SwissProt Accessions	Q6QIY3, Q62243, Q6EWG7, Q6KCH7, Q703F9	Gene names	Scn10a, Pn3, Sns
Domain Architecture	No domain graphic available
Description	Sodium channel protein type 10 subunit alpha (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) (Peripheral nerve sodium channel 3) (Sensory neuron sodium channel).

CAC1I_HUMAN
NC score	0.021989 (rank : 46)	θ value	1.06291 (rank : 39)
Query Neighborhood Hits	61	Target Neighborhood Hits	138	Shared Neighborhood Hits	9
SwissProt Accessions	Q9P0X4, O95504, Q5JZ88, Q7Z6S9, Q8NFX6, Q9NZC8, Q9UH15, Q9UH30, Q9ULU9, Q9UNE6	Gene names	CACNA1I, KIAA1120
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1I (Voltage- gated calcium channel subunit alpha Cav3.3) (Ca(v)3.3).

CAC1G_HUMAN
NC score	0.021783 (rank : 47)	θ value	0.813845 (rank : 36)
Query Neighborhood Hits	61	Target Neighborhood Hits	587	Shared Neighborhood Hits	11
SwissProt Accessions	O43497, O43498, O94770, Q9NYU4, Q9NYU5, Q9NYU6, Q9NYU7, Q9NYU8, Q9NYU9, Q9NYV0, Q9NYV1, Q9UHN9, Q9UHP0, Q9ULU6, Q9UNG7, Q9Y5T2, Q9Y5T3	Gene names	CACNA1G, KIAA1123
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1G (Voltage- gated calcium channel subunit alpha Cav3.1) (Cav3.1c) (NBR13).

SCN7A_HUMAN
NC score	0.019774 (rank : 48)	θ value	6.88961 (rank : 57)
Query Neighborhood Hits	61	Target Neighborhood Hits	135	Shared Neighborhood Hits	13
SwissProt Accessions	Q01118	Gene names	SCN7A, SCN6A
Domain Architecture
Description	Sodium channel protein type 7 subunit alpha (Sodium channel protein type VII subunit alpha) (Putative voltage-gated sodium channel alpha subunit Nax) (Sodium channel protein, cardiac and skeletal muscle alpha-subunit).

NUDT6_MOUSE
NC score	0.018535 (rank : 49)	θ value	6.88961 (rank : 56)
Query Neighborhood Hits	61	Target Neighborhood Hits	24	Shared Neighborhood Hits	4
SwissProt Accessions	Q8CH40, Q8R2T3	Gene names	Nudt6, Asfgf2b
Domain Architecture	No domain graphic available
Description	Nucleoside diphosphate-linked moiety X motif 6 (Nudix motif 6) (Antisense basic fibroblast growth factor B).

CAC1H_HUMAN
NC score	0.017143 (rank : 50)	θ value	4.03905 (rank : 46)
Query Neighborhood Hits	61	Target Neighborhood Hits	307	Shared Neighborhood Hits	12
SwissProt Accessions	O95180, O95802, Q8WWI6, Q96QI6, Q96RZ9, Q9NYY4, Q9NYY5	Gene names	CACNA1H
Domain Architecture
Description	Voltage-dependent T-type calcium channel subunit alpha-1H (Voltage- gated calcium channel subunit alpha Cav3.2) (Low-voltage-activated calcium channel alpha1 3.2 subunit).

SCN4A_HUMAN
NC score	0.016905 (rank : 51)	θ value	5.27518 (rank : 51)
Query Neighborhood Hits	61	Target Neighborhood Hits	133	Shared Neighborhood Hits	18
SwissProt Accessions	P35499, Q15478, Q16447, Q7Z6B1	Gene names	SCN4A
Domain Architecture
Description	Sodium channel protein type 4 subunit alpha (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) (Sodium channel protein, skeletal muscle subunit alpha) (SkM1).

BAK_MOUSE
NC score	0.016813 (rank : 52)	θ value	1.81305 (rank : 40)
Query Neighborhood Hits	61	Target Neighborhood Hits	24	Shared Neighborhood Hits	2
SwissProt Accessions	O08734	Gene names	Bak1, Bak
Domain Architecture
Description	Bcl-2 homologous antagonist/killer (Apoptosis regulator BAK).

MCM8_MOUSE
NC score	0.015112 (rank : 53)	θ value	1.81305 (rank : 41)
Query Neighborhood Hits	61	Target Neighborhood Hits	38	Shared Neighborhood Hits	3
SwissProt Accessions	Q9CWV1, Q80US2, Q80VI0	Gene names	Mcm8
Domain Architecture	No domain graphic available
Description	DNA replication licensing factor MCM8 (Minichromosome maintenance 8).

MCM8_HUMAN
NC score	0.014578 (rank : 54)	θ value	2.36792 (rank : 44)
Query Neighborhood Hits	61	Target Neighborhood Hits	25	Shared Neighborhood Hits	3
SwissProt Accessions	Q9UJA3, Q495R4, Q495R7, Q86US4, Q969I5	Gene names	MCM8, C20orf154
Domain Architecture
Description	DNA replication licensing factor MCM8 (Minichromosome maintenance 8).

MCES_MOUSE
NC score	0.014209 (rank : 55)	θ value	4.03905 (rank : 47)
Query Neighborhood Hits	61	Target Neighborhood Hits	88	Shared Neighborhood Hits	2
SwissProt Accessions	Q9D0L8, Q3V3U9, Q6ZQC6, Q9D5F1	Gene names	Rnmt, Kiaa0398
Domain Architecture	No domain graphic available
Description	mRNA cap guanine-N7 methyltransferase (EC 2.1.1.56) (mRNA (guanine- N(7)-)-methyltransferase) (RG7MT1) (mRNA cap methyltransferase).

DISC1_HUMAN
NC score	0.011658 (rank : 56)	θ value	5.27518 (rank : 48)
Query Neighborhood Hits	61	Target Neighborhood Hits	199	Shared Neighborhood Hits	8
SwissProt Accessions	Q9NRI5, O75045, Q5VT44, Q5VT45, Q8IXJ0, Q8IXJ1, Q9BX19, Q9NRI3, Q9NRI4	Gene names	DISC1, KIAA0457
Domain Architecture	No domain graphic available
Description	Disrupted in schizophrenia 1 protein.

FA62A_MOUSE
NC score	0.009714 (rank : 57)	θ value	2.36792 (rank : 43)
Query Neighborhood Hits	61	Target Neighborhood Hits	155	Shared Neighborhood Hits	2
SwissProt Accessions	Q3U7R1, Q8C8R1, Q91X62, Q9CVH0, Q9Z1X5, Q9Z1X6	Gene names	Fam62a, Mbc2
Domain Architecture	No domain graphic available
Description	Protein FAM62A (Membrane-bound C2 domain-containing protein).

SYNE1_HUMAN
NC score	0.008896 (rank : 58)	θ value	3.0926 (rank : 45)
Query Neighborhood Hits	61	Target Neighborhood Hits	1484	Shared Neighborhood Hits	17
SwissProt Accessions	Q8NF91, O94890, Q5JV19, Q5JV22, Q8N9P7, Q8TCP1, Q8WWW6, Q8WWW7, Q8WXF6, Q96N17, Q9C0A7, Q9H525, Q9H526, Q9NS36, Q9NU50, Q9UJ06, Q9UJ07, Q9ULF8	Gene names	SYNE1, KIAA0796, KIAA1262, KIAA1756, MYNE1
Domain Architecture
Description	Nesprin-1 (Nuclear envelope spectrin repeat protein 1) (Synaptic nuclear envelope protein 1) (Syne-1) (Myocyte nuclear envelope protein 1) (Myne-1) (Enaptin).

CCD46_HUMAN
NC score	0.004995 (rank : 59)	θ value	0.813845 (rank : 37)
Query Neighborhood Hits	61	Target Neighborhood Hits	1430	Shared Neighborhood Hits	13
SwissProt Accessions	Q8N8E3, Q6PIB5, Q8NCR4, Q8NFR4	Gene names	CCDC46
Domain Architecture	No domain graphic available
Description	Coiled-coil domain-containing protein 46.

CASP_MOUSE
NC score	0.004660 (rank : 60)	θ value	8.99809 (rank : 58)
Query Neighborhood Hits	61	Target Neighborhood Hits	1152	Shared Neighborhood Hits	14
SwissProt Accessions	P70403, Q7TQJ4, Q91WN6	Gene names	Cutl1
Domain Architecture	No domain graphic available
Description	Protein CASP.

SDCG8_HUMAN
NC score	0.003984 (rank : 61)	θ value	5.27518 (rank : 52)
Query Neighborhood Hits	61	Target Neighborhood Hits	1002	Shared Neighborhood Hits	10
SwissProt Accessions	Q86SQ7, O60527, Q3ZCR6, Q8N5F2, Q9P0F1	Gene names	SDCCAG8, CCCAP
Domain Architecture	No domain graphic available
Description	Serologically defined colon cancer antigen 8 (Centrosomal colon cancer autoantigen protein) (hCCCAP) (Antigen NY-CO-8).

CUTL1_MOUSE
NC score	0.003966 (rank : 62)	θ value	8.99809 (rank : 59)
Query Neighborhood Hits	61	Target Neighborhood Hits	1620	Shared Neighborhood Hits	15
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

MYOM1_HUMAN
NC score	0.002356 (rank : 63)	θ value	6.88961 (rank : 55)
Query Neighborhood Hits	61	Target Neighborhood Hits	405	Shared Neighborhood Hits	3
SwissProt Accessions	P52179	Gene names	MYOM1
Domain Architecture
Description	Myomesin-1 (190 kDa titin-associated protein) (190 kDa connectin- associated protein).

MAP1A_HUMAN
NC score	0.002330 (rank : 64)	θ value	6.88961 (rank : 54)
Query Neighborhood Hits	61	Target Neighborhood Hits	1626	Shared Neighborhood Hits	10
SwissProt Accessions	P78559, O95643, Q12973, Q15882, Q9UJT4	Gene names	MAP1A
Domain Architecture
Description	Microtubule-associated protein 1A (MAP 1A) (Proliferation-related protein p80) [Contains: MAP1 light chain LC2].

HMMR_MOUSE
NC score	0.002105 (rank : 65)	θ value	6.88961 (rank : 53)
Query Neighborhood Hits	61	Target Neighborhood Hits	1178	Shared Neighborhood Hits	11
SwissProt Accessions	Q00547	Gene names	Hmmr, Ihabp, Rhamm
Domain Architecture
Description	Hyaluronan mediated motility receptor (Intracellular hyaluronic acid- binding protein) (Receptor for hyaluronan-mediated motility).

IGS4B_HUMAN
NC score	0.001896 (rank : 66)	θ value	8.99809 (rank : 60)
Query Neighborhood Hits	61	Target Neighborhood Hits	305	Shared Neighborhood Hits	3
SwissProt Accessions	Q8N126, Q9NVJ5, Q9UJP1	Gene names	IGSF4B, NECL1, SYNCAM3, TSLL1
Domain Architecture	No domain graphic available
Description	Immunoglobulin superfamily member 4B precursor (Nectin-like protein 1) (TSLC1-like protein 1) (Synaptic cell adhesion molecule 3) (Brain immunoglobulin receptor).

LAMC3_MOUSE
NC score	0.000595 (rank : 67)	θ value	8.99809 (rank : 61)
Query Neighborhood Hits	61	Target Neighborhood Hits	624	Shared Neighborhood Hits	7
SwissProt Accessions	Q9R0B6, Q9WTW6	Gene names	Lamc3
Domain Architecture
Description	Laminin gamma-3 chain precursor (Laminin 12 gamma 3 subunit).

ROCK2_HUMAN
NC score	-0.000323 (rank : 68)	θ value	0.62314 (rank : 35)
Query Neighborhood Hits	61	Target Neighborhood Hits	2073	Shared Neighborhood Hits	12
SwissProt Accessions	O75116, Q9UQN5	Gene names	ROCK2, KIAA0619
Domain Architecture
Description	Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho-associated, coiled- coil-containing protein kinase 2) (p164 ROCK-2) (Rho kinase 2).