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Network neighborhood for query Sequence : SMOC1_MOUSE

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SMOC1_MOUSE
SwissProt Accessions	Q8BLY1, Q9WVN9	Gene names	Smoc1, Srg
Domain Architecture
Description	SPARC-related modular calcium-binding protein 1 precursor (Secreted modular calcium-binding protein 1) (SMOC-1) (SPARC-related gene protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SMOC1_HUMAN
θ value	0 (rank : 1)	NC score	0.994143 (rank : 2)
Query Neighborhood Hits	74	Target Neighborhood Hits	81	Shared Neighborhood Hits	64
SwissProt Accessions	Q9H4F8, Q96F78	Gene names	SMOC1
Domain Architecture
Description	SPARC-related modular calcium-binding protein 1 precursor (Secreted modular calcium-binding protein 1) (SMOC-1).

SMOC1_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BLY1, Q9WVN9	Gene names	Smoc1, Srg
Domain Architecture
Description	SPARC-related modular calcium-binding protein 1 precursor (Secreted modular calcium-binding protein 1) (SMOC-1) (SPARC-related gene protein).

SMOC2_MOUSE
θ value	1.80787e-125 (rank : 3)	NC score	0.972557 (rank : 3)
Query Neighborhood Hits	74	Target Neighborhood Hits	81	Shared Neighborhood Hits	54
SwissProt Accessions	Q8CD91, Q8VCM1, Q9D9K2, Q9ER95	Gene names	Smoc2
Domain Architecture
Description	SPARC-related modular calcium-binding protein 2 precursor (Secreted modular calcium-binding protein 2) (SMOC-2).

SMOC2_HUMAN
θ value	1.17183e-124 (rank : 4)	NC score	0.970263 (rank : 4)
Query Neighborhood Hits	74	Target Neighborhood Hits	88	Shared Neighborhood Hits	53
SwissProt Accessions	Q9H3U7, Q5TAT7, Q5TAT8, Q86VV9, Q96SF3, Q9H1L3, Q9H1L4, Q9H3U0, Q9H4F7, Q9HCV2	Gene names	SMOC2, SMAP2
Domain Architecture
Description	SPARC-related modular calcium-binding protein 2 precursor (Secreted modular calcium-binding protein 2) (SMOC-2) (Smooth muscle-associated protein 2) (SMAP-2).

THYG_HUMAN
θ value	2.0648e-12 (rank : 5)	NC score	0.347707 (rank : 25)
Query Neighborhood Hits	74	Target Neighborhood Hits	154	Shared Neighborhood Hits	35
SwissProt Accessions	P01266, O15274, O43899, Q15593, Q15948, Q9NYR1, Q9NYR2, Q9UMZ0, Q9UNY3	Gene names	TG
Domain Architecture
Description	Thyroglobulin precursor.

THYG_MOUSE
θ value	2.98157e-11 (rank : 6)	NC score	0.330585 (rank : 29)
Query Neighborhood Hits	74	Target Neighborhood Hits	161	Shared Neighborhood Hits	33
SwissProt Accessions	O08710, O88590, Q9QWY7	Gene names	Tg, Tgn
Domain Architecture
Description	Thyroglobulin precursor.

NID1_MOUSE
θ value	3.89403e-11 (rank : 7)	NC score	0.241311 (rank : 44)
Query Neighborhood Hits	74	Target Neighborhood Hits	335	Shared Neighborhood Hits	39
SwissProt Accessions	P10493, Q8BQI3, Q8C3U8, Q8C9P6	Gene names	Nid1, Ent
Domain Architecture
Description	Nidogen-1 precursor (Entactin).

NID1_HUMAN
θ value	5.62301e-10 (rank : 8)	NC score	0.244444 (rank : 43)
Query Neighborhood Hits	74	Target Neighborhood Hits	329	Shared Neighborhood Hits	39
SwissProt Accessions	P14543, Q14942, Q59FL2, Q5TAF2, Q5TAF3, Q86XD7	Gene names	NID1, NID
Domain Architecture
Description	Nidogen-1 precursor (Entactin).

NID2_HUMAN
θ value	1.63604e-09 (rank : 9)	NC score	0.264676 (rank : 41)
Query Neighborhood Hits	74	Target Neighborhood Hits	456	Shared Neighborhood Hits	40
SwissProt Accessions	Q14112, O43710	Gene names	NID2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Osteonidogen).

NID2_MOUSE
θ value	4.76016e-09 (rank : 10)	NC score	0.264845 (rank : 40)
Query Neighborhood Hits	74	Target Neighborhood Hits	338	Shared Neighborhood Hits	38
SwissProt Accessions	O88322	Gene names	Nid2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Entactin-2).

TICN2_HUMAN
θ value	1.80886e-08 (rank : 11)	NC score	0.514369 (rank : 7)
Query Neighborhood Hits	74	Target Neighborhood Hits	68	Shared Neighborhood Hits	58
SwissProt Accessions	Q92563, Q6UW87	Gene names	SPOCK2, KIAA0275, TICN2
Domain Architecture
Description	Testican-2 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2).

TICN1_HUMAN
θ value	1.99992e-07 (rank : 12)	NC score	0.481266 (rank : 8)
Query Neighborhood Hits	74	Target Neighborhood Hits	70	Shared Neighborhood Hits	52
SwissProt Accessions	Q08629	Gene names	SPOCK1, SPOCK, TIC1, TICN1
Domain Architecture
Description	Testican-1 precursor (Protein SPOCK).

HG2A_MOUSE
θ value	4.45536e-07 (rank : 13)	NC score	0.515619 (rank : 6)
Query Neighborhood Hits	74	Target Neighborhood Hits	36	Shared Neighborhood Hits	32
SwissProt Accessions	P04441, O19452	Gene names	Cd74, Ii
Domain Architecture
Description	H-2 class II histocompatibility antigen gamma chain (MHC class II- associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (CD74 antigen).

TICN2_MOUSE
θ value	5.81887e-07 (rank : 14)	NC score	0.515774 (rank : 5)
Query Neighborhood Hits	74	Target Neighborhood Hits	69	Shared Neighborhood Hits	57
SwissProt Accessions	Q9ER58	Gene names	Spock2, Ticn2
Domain Architecture
Description	Testican-2 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2).

TEFF2_HUMAN
θ value	3.77169e-06 (rank : 15)	NC score	0.323056 (rank : 32)
Query Neighborhood Hits	74	Target Neighborhood Hits	211	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UIK5, Q4ZFW4, Q53H90, Q53RE1, Q8N2R5, Q9NR15, Q9NSS5, Q9P2Y9, Q9UK65	Gene names	TMEFF2, HPP1, TENB2, TPEF
Domain Architecture	No domain graphic available
Description	Transmembrane protein with EGF-like and two follistatin-like domains 2 precursor (Transmembrane protein containing epidermal growth factor and follistatin domains) (Tomoregulin) (TR) (Hyperplastic polyposis protein 1).

TEFF2_MOUSE
θ value	3.77169e-06 (rank : 16)	NC score	0.322708 (rank : 33)
Query Neighborhood Hits	74	Target Neighborhood Hits	214	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QYM9, Q3UY20, Q8CDH1, Q9JJE3	Gene names	Tmeff2
Domain Architecture	No domain graphic available
Description	Transmembrane protein with EGF-like and two follistatin-like domains 2 precursor (Tomoregulin) (TR).

AGRIN_HUMAN
θ value	6.43352e-06 (rank : 17)	NC score	0.183108 (rank : 46)
Query Neighborhood Hits	74	Target Neighborhood Hits	582	Shared Neighborhood Hits	51
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

TICN1_MOUSE
θ value	6.43352e-06 (rank : 18)	NC score	0.478786 (rank : 9)
Query Neighborhood Hits	74	Target Neighborhood Hits	79	Shared Neighborhood Hits	54
SwissProt Accessions	Q62288	Gene names	Spock1, Spock, Ticn1
Domain Architecture
Description	Testican-1 precursor (Protein SPOCK).

FST_HUMAN
θ value	4.1701e-05 (rank : 19)	NC score	0.366168 (rank : 16)
Query Neighborhood Hits	74	Target Neighborhood Hits	129	Shared Neighborhood Hits	38
SwissProt Accessions	P19883, Q9BTH0	Gene names	FST
Domain Architecture
Description	Follistatin precursor (FS) (Activin-binding protein).

SPRC_MOUSE
θ value	7.1131e-05 (rank : 20)	NC score	0.366990 (rank : 15)
Query Neighborhood Hits	74	Target Neighborhood Hits	46	Shared Neighborhood Hits	25
SwissProt Accessions	P07214	Gene names	Sparc
Domain Architecture
Description	SPARC precursor (Secreted protein acidic and rich in cysteine) (Osteonectin) (ON) (Basement-membrane protein 40) (BM-40).

SPRC_HUMAN
θ value	9.29e-05 (rank : 21)	NC score	0.365749 (rank : 17)
Query Neighborhood Hits	74	Target Neighborhood Hits	45	Shared Neighborhood Hits	25
SwissProt Accessions	P09486	Gene names	SPARC, ON
Domain Architecture
Description	SPARC precursor (Secreted protein acidic and rich in cysteine) (Osteonectin) (ON) (Basement-membrane protein 40) (BM-40).

SPRL1_HUMAN
θ value	0.000158464 (rank : 22)	NC score	0.316922 (rank : 35)
Query Neighborhood Hits	74	Target Neighborhood Hits	231	Shared Neighborhood Hits	30
SwissProt Accessions	Q14515, Q14800	Gene names	SPARCL1
Domain Architecture
Description	SPARC-like protein 1 precursor (High endothelial venule protein) (Hevin) (MAST 9).

SPRL1_MOUSE
θ value	0.000158464 (rank : 23)	NC score	0.289911 (rank : 37)
Query Neighborhood Hits	74	Target Neighborhood Hits	403	Shared Neighborhood Hits	25
SwissProt Accessions	P70663, P97810, Q99L82	Gene names	Sparcl1, Ecm2, Sc1
Domain Architecture
Description	SPARC-like protein 1 precursor (Matrix glycoprotein Sc1) (Extracellular matrix protein 2).

TICN3_HUMAN
θ value	0.000158464 (rank : 24)	NC score	0.466678 (rank : 11)
Query Neighborhood Hits	74	Target Neighborhood Hits	82	Shared Neighborhood Hits	52
SwissProt Accessions	Q9BQ16, O75705, Q6UW53, Q96Q26	Gene names	SPOCK3, TICN3
Domain Architecture
Description	Testican-3 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3).

FSTL3_HUMAN
θ value	0.00020696 (rank : 25)	NC score	0.357140 (rank : 22)
Query Neighborhood Hits	74	Target Neighborhood Hits	162	Shared Neighborhood Hits	41
SwissProt Accessions	O95633	Gene names	FSTL3, FLRG
Domain Architecture
Description	Follistatin-related protein 3 precursor (Follistatin-like 3) (Follistatin-related gene protein).

FST_MOUSE
θ value	0.00020696 (rank : 26)	NC score	0.357419 (rank : 21)
Query Neighborhood Hits	74	Target Neighborhood Hits	146	Shared Neighborhood Hits	38
SwissProt Accessions	P47931	Gene names	Fst
Domain Architecture
Description	Follistatin precursor (FS) (Activin-binding protein).

HG2A_HUMAN
θ value	0.000270298 (rank : 27)	NC score	0.467313 (rank : 10)
Query Neighborhood Hits	74	Target Neighborhood Hits	36	Shared Neighborhood Hits	31
SwissProt Accessions	P04233, Q14597, Q29832, Q5U0J8, Q8WLP6	Gene names	CD74, DHLAG
Domain Architecture	No domain graphic available
Description	HLA class II histocompatibility antigen gamma chain (HLA-DR antigens- associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (p33) (CD74 antigen).

FSTL3_MOUSE
θ value	0.00035302 (rank : 28)	NC score	0.331496 (rank : 28)
Query Neighborhood Hits	74	Target Neighborhood Hits	152	Shared Neighborhood Hits	41
SwissProt Accessions	Q9EQC7	Gene names	Fstl3, Flrg
Domain Architecture
Description	Follistatin-related protein 3 precursor (Follistatin-like 3) (Follistatin-related gene protein).

TICN3_MOUSE
θ value	0.000461057 (rank : 29)	NC score	0.465245 (rank : 12)
Query Neighborhood Hits	74	Target Neighborhood Hits	83	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BKV0, Q9ER59	Gene names	Spock3
Domain Architecture	No domain graphic available
Description	Testican-3 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3).

IBP1_HUMAN
θ value	0.000602161 (rank : 30)	NC score	0.375692 (rank : 14)
Query Neighborhood Hits	74	Target Neighborhood Hits	67	Shared Neighborhood Hits	37
SwissProt Accessions	P08833, Q8IYP5	Gene names	IGFBP1, IBP1
Domain Architecture
Description	Insulin-like growth factor-binding protein 1 precursor (IGFBP-1) (IBP- 1) (IGF-binding protein 1) (Placental protein 12) (PP12).

IBP3_HUMAN
θ value	0.000602161 (rank : 31)	NC score	0.378221 (rank : 13)
Query Neighborhood Hits	74	Target Neighborhood Hits	67	Shared Neighborhood Hits	38
SwissProt Accessions	P17936, Q2V509, Q6P1M6	Gene names	IGFBP3, IBP3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

IBP2_MOUSE
θ value	0.00175202 (rank : 32)	NC score	0.354444 (rank : 23)
Query Neighborhood Hits	74	Target Neighborhood Hits	65	Shared Neighborhood Hits	37
SwissProt Accessions	P47877, Q61722	Gene names	Igfbp2, Igfbp-2
Domain Architecture
Description	Insulin-like growth factor-binding protein 2 precursor (IGFBP-2) (IBP- 2) (IGF-binding protein 2).

IBP1_MOUSE
θ value	0.00390308 (rank : 33)	NC score	0.350417 (rank : 24)
Query Neighborhood Hits	74	Target Neighborhood Hits	97	Shared Neighborhood Hits	35
SwissProt Accessions	P47876, Q61732	Gene names	Igfbp1, Igfbp-1
Domain Architecture
Description	Insulin-like growth factor-binding protein 1 precursor (IGFBP-1) (IBP- 1) (IGF-binding protein 1).

FSTL5_HUMAN
θ value	0.00665767 (rank : 34)	NC score	0.129539 (rank : 49)
Query Neighborhood Hits	74	Target Neighborhood Hits	347	Shared Neighborhood Hits	30
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

IBP4_HUMAN
θ value	0.00665767 (rank : 35)	NC score	0.357429 (rank : 20)
Query Neighborhood Hits	74	Target Neighborhood Hits	52	Shared Neighborhood Hits	38
SwissProt Accessions	P22692	Gene names	IGFBP4, IBP4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

IBP4_MOUSE
θ value	0.00665767 (rank : 36)	NC score	0.359520 (rank : 19)
Query Neighborhood Hits	74	Target Neighborhood Hits	55	Shared Neighborhood Hits	38
SwissProt Accessions	P47879, O35666	Gene names	Igfbp4, Igfbp-4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

IBP5_HUMAN
θ value	0.00665767 (rank : 37)	NC score	0.324436 (rank : 31)
Query Neighborhood Hits	74	Target Neighborhood Hits	68	Shared Neighborhood Hits	37
SwissProt Accessions	P24593	Gene names	IGFBP5, IBP5
Domain Architecture
Description	Insulin-like growth factor-binding protein 5 precursor (IGFBP-5) (IBP- 5) (IGF-binding protein 5).

KAZD1_MOUSE
θ value	0.00665767 (rank : 38)	NC score	0.174985 (rank : 48)
Query Neighborhood Hits	74	Target Neighborhood Hits	281	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

CFAI_MOUSE
θ value	0.00869519 (rank : 39)	NC score	0.040249 (rank : 84)
Query Neighborhood Hits	74	Target Neighborhood Hits	290	Shared Neighborhood Hits	20
SwissProt Accessions	Q61129, Q9WU07	Gene names	Cfi, If
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

FSTL5_MOUSE
θ value	0.00869519 (rank : 40)	NC score	0.129052 (rank : 50)
Query Neighborhood Hits	74	Target Neighborhood Hits	355	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BFR2, Q80TG3, Q8C4T3	Gene names	Fstl5, Kiaa1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5) (m- D/Bsp120I 1-2).

IBP5_MOUSE
θ value	0.00869519 (rank : 41)	NC score	0.320944 (rank : 34)
Query Neighborhood Hits	74	Target Neighborhood Hits	68	Shared Neighborhood Hits	37
SwissProt Accessions	Q07079	Gene names	Igfbp5, Igfbp-5
Domain Architecture
Description	Insulin-like growth factor-binding protein 5 precursor (IGFBP-5) (IBP- 5) (IGF-binding protein 5).

IBP2_HUMAN
θ value	0.0113563 (rank : 42)	NC score	0.329664 (rank : 30)
Query Neighborhood Hits	74	Target Neighborhood Hits	61	Shared Neighborhood Hits	37
SwissProt Accessions	P18065, Q14619, Q9UCL3	Gene names	IGFBP2, BP2
Domain Architecture
Description	Insulin-like growth factor-binding protein 2 precursor (IGFBP-2) (IBP- 2) (IGF-binding protein 2).

CO6_HUMAN
θ value	0.0148317 (rank : 43)	NC score	0.054000 (rank : 76)
Query Neighborhood Hits	74	Target Neighborhood Hits	331	Shared Neighborhood Hits	15
SwissProt Accessions	P13671	Gene names	C6
Domain Architecture
Description	Complement component C6 precursor.

IBP6_HUMAN
θ value	0.0148317 (rank : 44)	NC score	0.363808 (rank : 18)
Query Neighborhood Hits	74	Target Neighborhood Hits	55	Shared Neighborhood Hits	35
SwissProt Accessions	P24592, Q14492	Gene names	IGFBP6, IBP6
Domain Architecture
Description	Insulin-like growth factor-binding protein 6 precursor (IGFBP-6) (IBP- 6) (IGF-binding protein 6).

IBP3_MOUSE
θ value	0.0252991 (rank : 45)	NC score	0.343549 (rank : 27)
Query Neighborhood Hits	74	Target Neighborhood Hits	60	Shared Neighborhood Hits	37
SwissProt Accessions	P47878	Gene names	Igfbp3, Igfbp-3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

IBP6_MOUSE
θ value	0.0431538 (rank : 46)	NC score	0.344648 (rank : 26)
Query Neighborhood Hits	74	Target Neighborhood Hits	53	Shared Neighborhood Hits	36
SwissProt Accessions	P47880	Gene names	Igfbp6, Igfbp-6
Domain Architecture
Description	Insulin-like growth factor-binding protein 6 precursor (IGFBP-6) (IBP- 6) (IGF-binding protein 6).

KAZD1_HUMAN
θ value	0.0563607 (rank : 47)	NC score	0.178077 (rank : 47)
Query Neighborhood Hits	74	Target Neighborhood Hits	248	Shared Neighborhood Hits	41
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

TACD1_HUMAN
θ value	0.0563607 (rank : 48)	NC score	0.293757 (rank : 36)
Query Neighborhood Hits	74	Target Neighborhood Hits	34	Shared Neighborhood Hits	32
SwissProt Accessions	P16422, P18180, Q96C47	Gene names	TACSTD1, GA733-2, M1S2, TROP1
Domain Architecture
Description	Tumor-associated calcium signal transducer 1 precursor (Major gastrointestinal tumor-associated protein GA733-2) (Epithelial cell surface antigen) (Epithelial glycoprotein) (EGP) (Adenocarcinoma- associated antigen) (KSA) (KS 1/4 antigen) (Cell surface glycoprotein Trop-1) (CD326 antigen).

TACD2_HUMAN
θ value	0.125558 (rank : 49)	NC score	0.253964 (rank : 42)
Query Neighborhood Hits	74	Target Neighborhood Hits	41	Shared Neighborhood Hits	34
SwissProt Accessions	P09758, Q15658, Q96QD2	Gene names	TACSTD2, GA733-1, M1S1, TROP2
Domain Architecture
Description	Tumor-associated calcium signal transducer 2 precursor (Pancreatic carcinoma marker protein GA733-1) (Cell surface glycoprotein Trop-2).

FSTL4_HUMAN
θ value	0.21417 (rank : 50)	NC score	0.123893 (rank : 51)
Query Neighborhood Hits	74	Target Neighborhood Hits	344	Shared Neighborhood Hits	33
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

FSTL1_HUMAN
θ value	0.365318 (rank : 51)	NC score	0.272662 (rank : 39)
Query Neighborhood Hits	74	Target Neighborhood Hits	68	Shared Neighborhood Hits	39
SwissProt Accessions	Q12841	Gene names	FSTL1, FRP
Domain Architecture
Description	Follistatin-related protein 1 precursor (Follistatin-like 1).

FSTL1_MOUSE
θ value	0.365318 (rank : 52)	NC score	0.272926 (rank : 38)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	39
SwissProt Accessions	Q62356, Q99JI9	Gene names	Fstl1, Frp, Fstl, Tsc36
Domain Architecture
Description	Follistatin-related protein 1 precursor (Follistatin-like 1) (TGF- beta-inducible protein TSC-36).

HTRA1_MOUSE
θ value	0.62314 (rank : 53)	NC score	0.117170 (rank : 53)
Query Neighborhood Hits	74	Target Neighborhood Hits	140	Shared Neighborhood Hits	43
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

LAMB3_HUMAN
θ value	0.62314 (rank : 54)	NC score	0.033214 (rank : 86)
Query Neighborhood Hits	74	Target Neighborhood Hits	461	Shared Neighborhood Hits	14
SwissProt Accessions	Q13751, O14947, Q14733, Q9UJK4, Q9UJL1	Gene names	LAMB3
Domain Architecture
Description	Laminin beta-3 chain precursor (Laminin 5 beta 3) (Laminin B1k chain) (Kalinin B1 chain).

FSTL4_MOUSE
θ value	0.813845 (rank : 55)	NC score	0.123501 (rank : 52)
Query Neighborhood Hits	74	Target Neighborhood Hits	333	Shared Neighborhood Hits	35
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

LAMB2_MOUSE
θ value	0.813845 (rank : 56)	NC score	0.045173 (rank : 81)
Query Neighborhood Hits	74	Target Neighborhood Hits	722	Shared Neighborhood Hits	23
SwissProt Accessions	Q61292, Q62182	Gene names	Lamb2, Lams
Domain Architecture
Description	Laminin beta-2 chain precursor (S-laminin) (S-LAM).

HTRA1_HUMAN
θ value	1.06291 (rank : 57)	NC score	0.102607 (rank : 58)
Query Neighborhood Hits	74	Target Neighborhood Hits	155	Shared Neighborhood Hits	38
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

RECK_HUMAN
θ value	1.38821 (rank : 58)	NC score	0.079312 (rank : 62)
Query Neighborhood Hits	74	Target Neighborhood Hits	189	Shared Neighborhood Hits	28
SwissProt Accessions	O95980, Q8WX37	Gene names	RECK
Domain Architecture
Description	Reversion-inducing cysteine-rich protein with Kazal motifs precursor (hRECK) (Suppressor of tumorigenicity 15) (ST15).

RECK_MOUSE
θ value	1.38821 (rank : 59)	NC score	0.074886 (rank : 63)
Query Neighborhood Hits	74	Target Neighborhood Hits	158	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Z0J1	Gene names	Reck
Domain Architecture	No domain graphic available
Description	Reversion-inducing cysteine-rich protein with Kazal motifs precursor (mRECK).

MAML1_HUMAN
θ value	1.81305 (rank : 60)	NC score	0.031903 (rank : 87)
Query Neighborhood Hits	74	Target Neighborhood Hits	228	Shared Neighborhood Hits	3
SwissProt Accessions	Q92585, Q9NZ12	Gene names	MAML1, KIAA0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

ISK6_MOUSE
θ value	2.36792 (rank : 61)	NC score	0.187491 (rank : 45)
Query Neighborhood Hits	74	Target Neighborhood Hits	37	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BT20	Gene names	Spink6
Domain Architecture	No domain graphic available
Description	Serine protease inhibitor Kazal-type 6 precursor.

CFAI_HUMAN
θ value	3.0926 (rank : 62)	NC score	0.015069 (rank : 92)
Query Neighborhood Hits	74	Target Neighborhood Hits	289	Shared Neighborhood Hits	12
SwissProt Accessions	P05156, O60442	Gene names	CFI, IF
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

FBN2_HUMAN
θ value	3.0926 (rank : 63)	NC score	0.044317 (rank : 83)
Query Neighborhood Hits	74	Target Neighborhood Hits	560	Shared Neighborhood Hits	25
SwissProt Accessions	P35556	Gene names	FBN2
Domain Architecture
Description	Fibrillin-2 precursor.

FBN3_HUMAN
θ value	3.0926 (rank : 64)	NC score	0.045163 (rank : 82)
Query Neighborhood Hits	74	Target Neighborhood Hits	543	Shared Neighborhood Hits	24
SwissProt Accessions	Q75N90, Q75N91, Q75N92, Q75N93, Q86SJ5, Q96JP8	Gene names	FBN3, KIAA1776
Domain Architecture	No domain graphic available
Description	Fibrillin-3 precursor.

IBP7_HUMAN
θ value	3.0926 (rank : 65)	NC score	0.106027 (rank : 57)
Query Neighborhood Hits	74	Target Neighborhood Hits	220	Shared Neighborhood Hits	32
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

ISK4_MOUSE
θ value	3.0926 (rank : 66)	NC score	0.111994 (rank : 55)
Query Neighborhood Hits	74	Target Neighborhood Hits	28	Shared Neighborhood Hits	19
SwissProt Accessions	O35679	Gene names	Spink4, Mpgc60
Domain Architecture
Description	Serine protease inhibitor Kazal-type 4 precursor (Peptide PEC-60 homolog) (MPGC60 protein).

LAMB3_MOUSE
θ value	5.27518 (rank : 67)	NC score	0.027635 (rank : 89)
Query Neighborhood Hits	74	Target Neighborhood Hits	444	Shared Neighborhood Hits	15
SwissProt Accessions	Q61087	Gene names	Lamb3
Domain Architecture
Description	Laminin beta-3 chain precursor (Laminin 5 beta 3) (Kalinin B1 chain).

LCE2D_HUMAN
θ value	5.27518 (rank : 68)	NC score	0.037593 (rank : 85)
Query Neighborhood Hits	74	Target Neighborhood Hits	50	Shared Neighborhood Hits	5
SwissProt Accessions	Q5TA82	Gene names	LCE2D, LEP12, SPRL1A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2D (Late envelope protein 12) (Small proline-rich-like epidermal differentiation complex protein 1A).

PDE4D_HUMAN
θ value	6.88961 (rank : 69)	NC score	0.003785 (rank : 94)
Query Neighborhood Hits	74	Target Neighborhood Hits	122	Shared Neighborhood Hits	2
SwissProt Accessions	Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7	Gene names	PDE4D
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).

GP107_HUMAN
θ value	8.99809 (rank : 70)	NC score	0.008208 (rank : 93)
Query Neighborhood Hits	74	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q5VW38, Q5JPA3, Q5VW39, Q96T26, Q9H658, Q9HCE8	Gene names	GPR107, KIAA1624, LUSTR1
Domain Architecture	No domain graphic available
Description	Protein GPR107 precursor (Lung seven transmembrane receptor 1).

LAMB1_HUMAN
θ value	8.99809 (rank : 71)	NC score	0.025691 (rank : 90)
Query Neighborhood Hits	74	Target Neighborhood Hits	1018	Shared Neighborhood Hits	17
SwissProt Accessions	P07942	Gene names	LAMB1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

LAMB1_MOUSE
θ value	8.99809 (rank : 72)	NC score	0.029232 (rank : 88)
Query Neighborhood Hits	74	Target Neighborhood Hits	919	Shared Neighborhood Hits	18
SwissProt Accessions	P02469	Gene names	Lamb1-1, Lamb-1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

U383_HUMAN
θ value	8.99809 (rank : 73)	NC score	0.016649 (rank : 91)
Query Neighborhood Hits	74	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IYL2	Gene names	C4orf23
Domain Architecture	No domain graphic available
Description	Putative methyltransferase UPF0383 (EC 2.1.1.-).

ZN553_MOUSE
θ value	8.99809 (rank : 74)	NC score	-0.003614 (rank : 95)
Query Neighborhood Hits	74	Target Neighborhood Hits	744	Shared Neighborhood Hits	3
SwissProt Accessions	Q3US17, Q3UFP3, Q8R0V0, Q921H7	Gene names	Znf553, Zfp553
Domain Architecture	No domain graphic available
Description	Zinc finger protein 553.

EGF_HUMAN
θ value	θ > 10 (rank : 75)	NC score	0.055426 (rank : 75)
Query Neighborhood Hits	74	Target Neighborhood Hits	343	Shared Neighborhood Hits	14
SwissProt Accessions	P01133	Gene names	EGF
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor (Urogastrone)].

EGF_MOUSE
θ value	θ > 10 (rank : 76)	NC score	0.055728 (rank : 74)
Query Neighborhood Hits	74	Target Neighborhood Hits	358	Shared Neighborhood Hits	13
SwissProt Accessions	P01132, Q6P9J2	Gene names	Egf
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor].

HTRA3_HUMAN
θ value	θ > 10 (rank : 77)	NC score	0.058814 (rank : 69)
Query Neighborhood Hits	74	Target Neighborhood Hits	152	Shared Neighborhood Hits	30
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

HTRA3_MOUSE
θ value	θ > 10 (rank : 78)	NC score	0.057128 (rank : 71)
Query Neighborhood Hits	74	Target Neighborhood Hits	156	Shared Neighborhood Hits	29
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

IBP7_MOUSE
θ value	θ > 10 (rank : 79)	NC score	0.097184 (rank : 60)
Query Neighborhood Hits	74	Target Neighborhood Hits	230	Shared Neighborhood Hits	31
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

IPK1_HUMAN
θ value	θ > 10 (rank : 80)	NC score	0.086271 (rank : 61)
Query Neighborhood Hits	74	Target Neighborhood Hits	38	Shared Neighborhood Hits	21
SwissProt Accessions	P00995	Gene names	SPINK1, PSTI
Domain Architecture
Description	Pancreatic secretory trypsin inhibitor precursor (Tumor-associated trypsin inhibitor) (TATI) (Serine protease inhibitor Kazal-type 1).

IPK2_HUMAN
θ value	θ > 10 (rank : 81)	NC score	0.062596 (rank : 67)
Query Neighborhood Hits	74	Target Neighborhood Hits	30	Shared Neighborhood Hits	18
SwissProt Accessions	P20155	Gene names	SPINK2
Domain Architecture
Description	Serine protease inhibitor Kazal-type 2 precursor (Acrosin-trypsin inhibitor) (HUSI-II).

ISK3_MOUSE
θ value	θ > 10 (rank : 82)	NC score	0.062872 (rank : 66)
Query Neighborhood Hits	74	Target Neighborhood Hits	36	Shared Neighborhood Hits	18
SwissProt Accessions	P09036, Q5M9M3	Gene names	Spink3
Domain Architecture
Description	Serine protease inhibitor Kazal-type 3 precursor (Prostatic secretory glycoprotein) (P12).

ISK4_HUMAN
θ value	θ > 10 (rank : 83)	NC score	0.101159 (rank : 59)
Query Neighborhood Hits	74	Target Neighborhood Hits	28	Shared Neighborhood Hits	18
SwissProt Accessions	O60575	Gene names	SPINK4
Domain Architecture
Description	Serine protease inhibitor Kazal-type 4 precursor (Peptide PEC-60 homolog).

ISK5_HUMAN
θ value	θ > 10 (rank : 84)	NC score	0.107114 (rank : 56)
Query Neighborhood Hits	74	Target Neighborhood Hits	89	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NQ38, O75770, Q96PP2, Q96PP3	Gene names	SPINK5
Domain Architecture
Description	Serine protease inhibitor Kazal-type 5 precursor (Lympho-epithelial Kazal-type-related inhibitor) (LEKTI) [Contains: Hemofiltrate peptide HF6478; Hemofiltrate peptide HF7665].

ISK6_HUMAN
θ value	θ > 10 (rank : 85)	NC score	0.113275 (rank : 54)
Query Neighborhood Hits	74	Target Neighborhood Hits	32	Shared Neighborhood Hits	21
SwissProt Accessions	Q6UWN8, Q8N5P0	Gene names	SPINK6
Domain Architecture	No domain graphic available
Description	Serine protease inhibitor Kazal-type 6 precursor.

ISK7_HUMAN
θ value	θ > 10 (rank : 86)	NC score	0.073737 (rank : 64)
Query Neighborhood Hits	74	Target Neighborhood Hits	31	Shared Neighborhood Hits	18
SwissProt Accessions	P58062	Gene names	SPINK7, ECG2
Domain Architecture
Description	Serine protease inhibitor Kazal-type 7 precursor (Esophagus cancer- related gene 2 protein) (ECRG-2).

ISK7_MOUSE
θ value	θ > 10 (rank : 87)	NC score	0.067550 (rank : 65)
Query Neighborhood Hits	74	Target Neighborhood Hits	28	Shared Neighborhood Hits	19
SwissProt Accessions	Q6IE32	Gene names	Spink7, Ecg2
Domain Architecture	No domain graphic available
Description	Serine protease inhibitor Kazal-type 7 precursor (Esophagus cancer- related gene 2 protein) (ECRG-2).

LDLR_MOUSE
θ value	θ > 10 (rank : 88)	NC score	0.051771 (rank : 77)
Query Neighborhood Hits	74	Target Neighborhood Hits	382	Shared Neighborhood Hits	15
SwissProt Accessions	P35951	Gene names	Ldlr
Domain Architecture
Description	Low-density lipoprotein receptor precursor (LDL receptor).

LRP4_HUMAN
θ value	θ > 10 (rank : 89)	NC score	0.050154 (rank : 80)
Query Neighborhood Hits	74	Target Neighborhood Hits	355	Shared Neighborhood Hits	14
SwissProt Accessions	O75096	Gene names	LRP4, KIAA0816, MEGF7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 4 precursor (Multiple epidermal growth factor-like domains 7).

LRP5_HUMAN
θ value	θ > 10 (rank : 90)	NC score	0.059025 (rank : 68)
Query Neighborhood Hits	74	Target Neighborhood Hits	224	Shared Neighborhood Hits	11
SwissProt Accessions	O75197, Q96TD6, Q9UP66	Gene names	LRP5, LRP7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor.

LRP5_MOUSE
θ value	θ > 10 (rank : 91)	NC score	0.058731 (rank : 70)
Query Neighborhood Hits	74	Target Neighborhood Hits	236	Shared Neighborhood Hits	11
SwissProt Accessions	Q91VN0, O88883, Q9R208	Gene names	Lrp5, Lrp7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor (LRP7) (Lr3).

LRP6_HUMAN
θ value	θ > 10 (rank : 92)	NC score	0.057051 (rank : 72)
Query Neighborhood Hits	74	Target Neighborhood Hits	235	Shared Neighborhood Hits	9
SwissProt Accessions	O75581	Gene names	LRP6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

LRP6_MOUSE
θ value	θ > 10 (rank : 93)	NC score	0.056929 (rank : 73)
Query Neighborhood Hits	74	Target Neighborhood Hits	232	Shared Neighborhood Hits	10
SwissProt Accessions	O88572	Gene names	Lrp6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

LRP8_HUMAN
θ value	θ > 10 (rank : 94)	NC score	0.050827 (rank : 78)
Query Neighborhood Hits	74	Target Neighborhood Hits	346	Shared Neighborhood Hits	14
SwissProt Accessions	Q14114, O14968, Q86V27, Q99876, Q9BR78	Gene names	LRP8, APOER2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

LRP8_MOUSE
θ value	θ > 10 (rank : 95)	NC score	0.050495 (rank : 79)
Query Neighborhood Hits	74	Target Neighborhood Hits	385	Shared Neighborhood Hits	16
SwissProt Accessions	Q924X6, Q8CAK9, Q8CDF5, Q921B6	Gene names	Lrp8, Apoer2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

Hits sorted by NC score

SMOC1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	74
SwissProt Accessions	Q8BLY1, Q9WVN9	Gene names	Smoc1, Srg
Domain Architecture
Description	SPARC-related modular calcium-binding protein 1 precursor (Secreted modular calcium-binding protein 1) (SMOC-1) (SPARC-related gene protein).

SMOC1_HUMAN
NC score	0.994143 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	74	Target Neighborhood Hits	81	Shared Neighborhood Hits	64
SwissProt Accessions	Q9H4F8, Q96F78	Gene names	SMOC1
Domain Architecture
Description	SPARC-related modular calcium-binding protein 1 precursor (Secreted modular calcium-binding protein 1) (SMOC-1).

SMOC2_MOUSE
NC score	0.972557 (rank : 3)	θ value	1.80787e-125 (rank : 3)
Query Neighborhood Hits	74	Target Neighborhood Hits	81	Shared Neighborhood Hits	54
SwissProt Accessions	Q8CD91, Q8VCM1, Q9D9K2, Q9ER95	Gene names	Smoc2
Domain Architecture
Description	SPARC-related modular calcium-binding protein 2 precursor (Secreted modular calcium-binding protein 2) (SMOC-2).

SMOC2_HUMAN
NC score	0.970263 (rank : 4)	θ value	1.17183e-124 (rank : 4)
Query Neighborhood Hits	74	Target Neighborhood Hits	88	Shared Neighborhood Hits	53
SwissProt Accessions	Q9H3U7, Q5TAT7, Q5TAT8, Q86VV9, Q96SF3, Q9H1L3, Q9H1L4, Q9H3U0, Q9H4F7, Q9HCV2	Gene names	SMOC2, SMAP2
Domain Architecture
Description	SPARC-related modular calcium-binding protein 2 precursor (Secreted modular calcium-binding protein 2) (SMOC-2) (Smooth muscle-associated protein 2) (SMAP-2).

TICN2_MOUSE
NC score	0.515774 (rank : 5)	θ value	5.81887e-07 (rank : 14)
Query Neighborhood Hits	74	Target Neighborhood Hits	69	Shared Neighborhood Hits	57
SwissProt Accessions	Q9ER58	Gene names	Spock2, Ticn2
Domain Architecture
Description	Testican-2 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2).

HG2A_MOUSE
NC score	0.515619 (rank : 6)	θ value	4.45536e-07 (rank : 13)
Query Neighborhood Hits	74	Target Neighborhood Hits	36	Shared Neighborhood Hits	32
SwissProt Accessions	P04441, O19452	Gene names	Cd74, Ii
Domain Architecture
Description	H-2 class II histocompatibility antigen gamma chain (MHC class II- associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (CD74 antigen).

TICN2_HUMAN
NC score	0.514369 (rank : 7)	θ value	1.80886e-08 (rank : 11)
Query Neighborhood Hits	74	Target Neighborhood Hits	68	Shared Neighborhood Hits	58
SwissProt Accessions	Q92563, Q6UW87	Gene names	SPOCK2, KIAA0275, TICN2
Domain Architecture
Description	Testican-2 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 2).

TICN1_HUMAN
NC score	0.481266 (rank : 8)	θ value	1.99992e-07 (rank : 12)
Query Neighborhood Hits	74	Target Neighborhood Hits	70	Shared Neighborhood Hits	52
SwissProt Accessions	Q08629	Gene names	SPOCK1, SPOCK, TIC1, TICN1
Domain Architecture
Description	Testican-1 precursor (Protein SPOCK).

TICN1_MOUSE
NC score	0.478786 (rank : 9)	θ value	6.43352e-06 (rank : 18)
Query Neighborhood Hits	74	Target Neighborhood Hits	79	Shared Neighborhood Hits	54
SwissProt Accessions	Q62288	Gene names	Spock1, Spock, Ticn1
Domain Architecture
Description	Testican-1 precursor (Protein SPOCK).

HG2A_HUMAN
NC score	0.467313 (rank : 10)	θ value	0.000270298 (rank : 27)
Query Neighborhood Hits	74	Target Neighborhood Hits	36	Shared Neighborhood Hits	31
SwissProt Accessions	P04233, Q14597, Q29832, Q5U0J8, Q8WLP6	Gene names	CD74, DHLAG
Domain Architecture	No domain graphic available
Description	HLA class II histocompatibility antigen gamma chain (HLA-DR antigens- associated invariant chain) (Ia antigen-associated invariant chain) (Ii) (p33) (CD74 antigen).

TICN3_HUMAN
NC score	0.466678 (rank : 11)	θ value	0.000158464 (rank : 24)
Query Neighborhood Hits	74	Target Neighborhood Hits	82	Shared Neighborhood Hits	52
SwissProt Accessions	Q9BQ16, O75705, Q6UW53, Q96Q26	Gene names	SPOCK3, TICN3
Domain Architecture
Description	Testican-3 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3).

TICN3_MOUSE
NC score	0.465245 (rank : 12)	θ value	0.000461057 (rank : 29)
Query Neighborhood Hits	74	Target Neighborhood Hits	83	Shared Neighborhood Hits	55
SwissProt Accessions	Q8BKV0, Q9ER59	Gene names	Spock3
Domain Architecture	No domain graphic available
Description	Testican-3 precursor (SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3).

IBP3_HUMAN
NC score	0.378221 (rank : 13)	θ value	0.000602161 (rank : 31)
Query Neighborhood Hits	74	Target Neighborhood Hits	67	Shared Neighborhood Hits	38
SwissProt Accessions	P17936, Q2V509, Q6P1M6	Gene names	IGFBP3, IBP3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

IBP1_HUMAN
NC score	0.375692 (rank : 14)	θ value	0.000602161 (rank : 30)
Query Neighborhood Hits	74	Target Neighborhood Hits	67	Shared Neighborhood Hits	37
SwissProt Accessions	P08833, Q8IYP5	Gene names	IGFBP1, IBP1
Domain Architecture
Description	Insulin-like growth factor-binding protein 1 precursor (IGFBP-1) (IBP- 1) (IGF-binding protein 1) (Placental protein 12) (PP12).

SPRC_MOUSE
NC score	0.366990 (rank : 15)	θ value	7.1131e-05 (rank : 20)
Query Neighborhood Hits	74	Target Neighborhood Hits	46	Shared Neighborhood Hits	25
SwissProt Accessions	P07214	Gene names	Sparc
Domain Architecture
Description	SPARC precursor (Secreted protein acidic and rich in cysteine) (Osteonectin) (ON) (Basement-membrane protein 40) (BM-40).

FST_HUMAN
NC score	0.366168 (rank : 16)	θ value	4.1701e-05 (rank : 19)
Query Neighborhood Hits	74	Target Neighborhood Hits	129	Shared Neighborhood Hits	38
SwissProt Accessions	P19883, Q9BTH0	Gene names	FST
Domain Architecture
Description	Follistatin precursor (FS) (Activin-binding protein).

SPRC_HUMAN
NC score	0.365749 (rank : 17)	θ value	9.29e-05 (rank : 21)
Query Neighborhood Hits	74	Target Neighborhood Hits	45	Shared Neighborhood Hits	25
SwissProt Accessions	P09486	Gene names	SPARC, ON
Domain Architecture
Description	SPARC precursor (Secreted protein acidic and rich in cysteine) (Osteonectin) (ON) (Basement-membrane protein 40) (BM-40).

IBP6_HUMAN
NC score	0.363808 (rank : 18)	θ value	0.0148317 (rank : 44)
Query Neighborhood Hits	74	Target Neighborhood Hits	55	Shared Neighborhood Hits	35
SwissProt Accessions	P24592, Q14492	Gene names	IGFBP6, IBP6
Domain Architecture
Description	Insulin-like growth factor-binding protein 6 precursor (IGFBP-6) (IBP- 6) (IGF-binding protein 6).

IBP4_MOUSE
NC score	0.359520 (rank : 19)	θ value	0.00665767 (rank : 36)
Query Neighborhood Hits	74	Target Neighborhood Hits	55	Shared Neighborhood Hits	38
SwissProt Accessions	P47879, O35666	Gene names	Igfbp4, Igfbp-4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

IBP4_HUMAN
NC score	0.357429 (rank : 20)	θ value	0.00665767 (rank : 35)
Query Neighborhood Hits	74	Target Neighborhood Hits	52	Shared Neighborhood Hits	38
SwissProt Accessions	P22692	Gene names	IGFBP4, IBP4
Domain Architecture
Description	Insulin-like growth factor-binding protein 4 precursor (IGFBP-4) (IBP- 4) (IGF-binding protein 4).

FST_MOUSE
NC score	0.357419 (rank : 21)	θ value	0.00020696 (rank : 26)
Query Neighborhood Hits	74	Target Neighborhood Hits	146	Shared Neighborhood Hits	38
SwissProt Accessions	P47931	Gene names	Fst
Domain Architecture
Description	Follistatin precursor (FS) (Activin-binding protein).

FSTL3_HUMAN
NC score	0.357140 (rank : 22)	θ value	0.00020696 (rank : 25)
Query Neighborhood Hits	74	Target Neighborhood Hits	162	Shared Neighborhood Hits	41
SwissProt Accessions	O95633	Gene names	FSTL3, FLRG
Domain Architecture
Description	Follistatin-related protein 3 precursor (Follistatin-like 3) (Follistatin-related gene protein).

IBP2_MOUSE
NC score	0.354444 (rank : 23)	θ value	0.00175202 (rank : 32)
Query Neighborhood Hits	74	Target Neighborhood Hits	65	Shared Neighborhood Hits	37
SwissProt Accessions	P47877, Q61722	Gene names	Igfbp2, Igfbp-2
Domain Architecture
Description	Insulin-like growth factor-binding protein 2 precursor (IGFBP-2) (IBP- 2) (IGF-binding protein 2).

IBP1_MOUSE
NC score	0.350417 (rank : 24)	θ value	0.00390308 (rank : 33)
Query Neighborhood Hits	74	Target Neighborhood Hits	97	Shared Neighborhood Hits	35
SwissProt Accessions	P47876, Q61732	Gene names	Igfbp1, Igfbp-1
Domain Architecture
Description	Insulin-like growth factor-binding protein 1 precursor (IGFBP-1) (IBP- 1) (IGF-binding protein 1).

THYG_HUMAN
NC score	0.347707 (rank : 25)	θ value	2.0648e-12 (rank : 5)
Query Neighborhood Hits	74	Target Neighborhood Hits	154	Shared Neighborhood Hits	35
SwissProt Accessions	P01266, O15274, O43899, Q15593, Q15948, Q9NYR1, Q9NYR2, Q9UMZ0, Q9UNY3	Gene names	TG
Domain Architecture
Description	Thyroglobulin precursor.

IBP6_MOUSE
NC score	0.344648 (rank : 26)	θ value	0.0431538 (rank : 46)
Query Neighborhood Hits	74	Target Neighborhood Hits	53	Shared Neighborhood Hits	36
SwissProt Accessions	P47880	Gene names	Igfbp6, Igfbp-6
Domain Architecture
Description	Insulin-like growth factor-binding protein 6 precursor (IGFBP-6) (IBP- 6) (IGF-binding protein 6).

IBP3_MOUSE
NC score	0.343549 (rank : 27)	θ value	0.0252991 (rank : 45)
Query Neighborhood Hits	74	Target Neighborhood Hits	60	Shared Neighborhood Hits	37
SwissProt Accessions	P47878	Gene names	Igfbp3, Igfbp-3
Domain Architecture
Description	Insulin-like growth factor-binding protein 3 precursor (IGFBP-3) (IBP- 3) (IGF-binding protein 3).

FSTL3_MOUSE
NC score	0.331496 (rank : 28)	θ value	0.00035302 (rank : 28)
Query Neighborhood Hits	74	Target Neighborhood Hits	152	Shared Neighborhood Hits	41
SwissProt Accessions	Q9EQC7	Gene names	Fstl3, Flrg
Domain Architecture
Description	Follistatin-related protein 3 precursor (Follistatin-like 3) (Follistatin-related gene protein).

THYG_MOUSE
NC score	0.330585 (rank : 29)	θ value	2.98157e-11 (rank : 6)
Query Neighborhood Hits	74	Target Neighborhood Hits	161	Shared Neighborhood Hits	33
SwissProt Accessions	O08710, O88590, Q9QWY7	Gene names	Tg, Tgn
Domain Architecture
Description	Thyroglobulin precursor.

IBP2_HUMAN
NC score	0.329664 (rank : 30)	θ value	0.0113563 (rank : 42)
Query Neighborhood Hits	74	Target Neighborhood Hits	61	Shared Neighborhood Hits	37
SwissProt Accessions	P18065, Q14619, Q9UCL3	Gene names	IGFBP2, BP2
Domain Architecture
Description	Insulin-like growth factor-binding protein 2 precursor (IGFBP-2) (IBP- 2) (IGF-binding protein 2).

IBP5_HUMAN
NC score	0.324436 (rank : 31)	θ value	0.00665767 (rank : 37)
Query Neighborhood Hits	74	Target Neighborhood Hits	68	Shared Neighborhood Hits	37
SwissProt Accessions	P24593	Gene names	IGFBP5, IBP5
Domain Architecture
Description	Insulin-like growth factor-binding protein 5 precursor (IGFBP-5) (IBP- 5) (IGF-binding protein 5).

TEFF2_HUMAN
NC score	0.323056 (rank : 32)	θ value	3.77169e-06 (rank : 15)
Query Neighborhood Hits	74	Target Neighborhood Hits	211	Shared Neighborhood Hits	39
SwissProt Accessions	Q9UIK5, Q4ZFW4, Q53H90, Q53RE1, Q8N2R5, Q9NR15, Q9NSS5, Q9P2Y9, Q9UK65	Gene names	TMEFF2, HPP1, TENB2, TPEF
Domain Architecture	No domain graphic available
Description	Transmembrane protein with EGF-like and two follistatin-like domains 2 precursor (Transmembrane protein containing epidermal growth factor and follistatin domains) (Tomoregulin) (TR) (Hyperplastic polyposis protein 1).

TEFF2_MOUSE
NC score	0.322708 (rank : 33)	θ value	3.77169e-06 (rank : 16)
Query Neighborhood Hits	74	Target Neighborhood Hits	214	Shared Neighborhood Hits	39
SwissProt Accessions	Q9QYM9, Q3UY20, Q8CDH1, Q9JJE3	Gene names	Tmeff2
Domain Architecture	No domain graphic available
Description	Transmembrane protein with EGF-like and two follistatin-like domains 2 precursor (Tomoregulin) (TR).

IBP5_MOUSE
NC score	0.320944 (rank : 34)	θ value	0.00869519 (rank : 41)
Query Neighborhood Hits	74	Target Neighborhood Hits	68	Shared Neighborhood Hits	37
SwissProt Accessions	Q07079	Gene names	Igfbp5, Igfbp-5
Domain Architecture
Description	Insulin-like growth factor-binding protein 5 precursor (IGFBP-5) (IBP- 5) (IGF-binding protein 5).

SPRL1_HUMAN
NC score	0.316922 (rank : 35)	θ value	0.000158464 (rank : 22)
Query Neighborhood Hits	74	Target Neighborhood Hits	231	Shared Neighborhood Hits	30
SwissProt Accessions	Q14515, Q14800	Gene names	SPARCL1
Domain Architecture
Description	SPARC-like protein 1 precursor (High endothelial venule protein) (Hevin) (MAST 9).

TACD1_HUMAN
NC score	0.293757 (rank : 36)	θ value	0.0563607 (rank : 48)
Query Neighborhood Hits	74	Target Neighborhood Hits	34	Shared Neighborhood Hits	32
SwissProt Accessions	P16422, P18180, Q96C47	Gene names	TACSTD1, GA733-2, M1S2, TROP1
Domain Architecture
Description	Tumor-associated calcium signal transducer 1 precursor (Major gastrointestinal tumor-associated protein GA733-2) (Epithelial cell surface antigen) (Epithelial glycoprotein) (EGP) (Adenocarcinoma- associated antigen) (KSA) (KS 1/4 antigen) (Cell surface glycoprotein Trop-1) (CD326 antigen).

SPRL1_MOUSE
NC score	0.289911 (rank : 37)	θ value	0.000158464 (rank : 23)
Query Neighborhood Hits	74	Target Neighborhood Hits	403	Shared Neighborhood Hits	25
SwissProt Accessions	P70663, P97810, Q99L82	Gene names	Sparcl1, Ecm2, Sc1
Domain Architecture
Description	SPARC-like protein 1 precursor (Matrix glycoprotein Sc1) (Extracellular matrix protein 2).

FSTL1_MOUSE
NC score	0.272926 (rank : 38)	θ value	0.365318 (rank : 52)
Query Neighborhood Hits	74	Target Neighborhood Hits	74	Shared Neighborhood Hits	39
SwissProt Accessions	Q62356, Q99JI9	Gene names	Fstl1, Frp, Fstl, Tsc36
Domain Architecture
Description	Follistatin-related protein 1 precursor (Follistatin-like 1) (TGF- beta-inducible protein TSC-36).

FSTL1_HUMAN
NC score	0.272662 (rank : 39)	θ value	0.365318 (rank : 51)
Query Neighborhood Hits	74	Target Neighborhood Hits	68	Shared Neighborhood Hits	39
SwissProt Accessions	Q12841	Gene names	FSTL1, FRP
Domain Architecture
Description	Follistatin-related protein 1 precursor (Follistatin-like 1).

NID2_MOUSE
NC score	0.264845 (rank : 40)	θ value	4.76016e-09 (rank : 10)
Query Neighborhood Hits	74	Target Neighborhood Hits	338	Shared Neighborhood Hits	38
SwissProt Accessions	O88322	Gene names	Nid2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Entactin-2).

NID2_HUMAN
NC score	0.264676 (rank : 41)	θ value	1.63604e-09 (rank : 9)
Query Neighborhood Hits	74	Target Neighborhood Hits	456	Shared Neighborhood Hits	40
SwissProt Accessions	Q14112, O43710	Gene names	NID2
Domain Architecture
Description	Nidogen-2 precursor (NID-2) (Osteonidogen).

TACD2_HUMAN
NC score	0.253964 (rank : 42)	θ value	0.125558 (rank : 49)
Query Neighborhood Hits	74	Target Neighborhood Hits	41	Shared Neighborhood Hits	34
SwissProt Accessions	P09758, Q15658, Q96QD2	Gene names	TACSTD2, GA733-1, M1S1, TROP2
Domain Architecture
Description	Tumor-associated calcium signal transducer 2 precursor (Pancreatic carcinoma marker protein GA733-1) (Cell surface glycoprotein Trop-2).

NID1_HUMAN
NC score	0.244444 (rank : 43)	θ value	5.62301e-10 (rank : 8)
Query Neighborhood Hits	74	Target Neighborhood Hits	329	Shared Neighborhood Hits	39
SwissProt Accessions	P14543, Q14942, Q59FL2, Q5TAF2, Q5TAF3, Q86XD7	Gene names	NID1, NID
Domain Architecture
Description	Nidogen-1 precursor (Entactin).

NID1_MOUSE
NC score	0.241311 (rank : 44)	θ value	3.89403e-11 (rank : 7)
Query Neighborhood Hits	74	Target Neighborhood Hits	335	Shared Neighborhood Hits	39
SwissProt Accessions	P10493, Q8BQI3, Q8C3U8, Q8C9P6	Gene names	Nid1, Ent
Domain Architecture
Description	Nidogen-1 precursor (Entactin).

ISK6_MOUSE
NC score	0.187491 (rank : 45)	θ value	2.36792 (rank : 61)
Query Neighborhood Hits	74	Target Neighborhood Hits	37	Shared Neighborhood Hits	26
SwissProt Accessions	Q8BT20	Gene names	Spink6
Domain Architecture	No domain graphic available
Description	Serine protease inhibitor Kazal-type 6 precursor.

AGRIN_HUMAN
NC score	0.183108 (rank : 46)	θ value	6.43352e-06 (rank : 17)
Query Neighborhood Hits	74	Target Neighborhood Hits	582	Shared Neighborhood Hits	51
SwissProt Accessions	O00468, Q5SVA2, Q60FE1, Q7KYS8, Q8N4J5, Q96IC1, Q9BTD4	Gene names	AGRIN, AGRN
Domain Architecture	No domain graphic available
Description	Agrin precursor.

KAZD1_HUMAN
NC score	0.178077 (rank : 47)	θ value	0.0563607 (rank : 47)
Query Neighborhood Hits	74	Target Neighborhood Hits	248	Shared Neighborhood Hits	41
SwissProt Accessions	Q96I82, Q6ZMB1, Q9BQ73	Gene names	KAZALD1
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor.

KAZD1_MOUSE
NC score	0.174985 (rank : 48)	θ value	0.00665767 (rank : 38)
Query Neighborhood Hits	74	Target Neighborhood Hits	281	Shared Neighborhood Hits	42
SwissProt Accessions	Q8BJ66	Gene names	Kazald1, Bono1, Igfbprp10
Domain Architecture	No domain graphic available
Description	Kazal-type serine protease inhibitor domain-containing protein 1 precursor (IGFBP-related protein 10) (IGFBP-rP10) (Bone and odontoblast expressed protein 1).

FSTL5_HUMAN
NC score	0.129539 (rank : 49)	θ value	0.00665767 (rank : 34)
Query Neighborhood Hits	74	Target Neighborhood Hits	347	Shared Neighborhood Hits	30
SwissProt Accessions	Q8N475, Q9NSW7, Q9ULF7	Gene names	FSTL5, KIAA1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5).

FSTL5_MOUSE
NC score	0.129052 (rank : 50)	θ value	0.00869519 (rank : 40)
Query Neighborhood Hits	74	Target Neighborhood Hits	355	Shared Neighborhood Hits	30
SwissProt Accessions	Q8BFR2, Q80TG3, Q8C4T3	Gene names	Fstl5, Kiaa1263
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 5 precursor (Follistatin-like 5) (m- D/Bsp120I 1-2).

FSTL4_HUMAN
NC score	0.123893 (rank : 51)	θ value	0.21417 (rank : 50)
Query Neighborhood Hits	74	Target Neighborhood Hits	344	Shared Neighborhood Hits	33
SwissProt Accessions	Q6MZW2, Q8TBU0, Q9UPU1	Gene names	FSTL4, KIAA1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4).

FSTL4_MOUSE
NC score	0.123501 (rank : 52)	θ value	0.813845 (rank : 55)
Query Neighborhood Hits	74	Target Neighborhood Hits	333	Shared Neighborhood Hits	35
SwissProt Accessions	Q5STE3, Q5DU03	Gene names	Fstl4, Kiaa1061
Domain Architecture	No domain graphic available
Description	Follistatin-related protein 4 precursor (Follistatin-like 4) (m- D/Bsp120I 1-1).

HTRA1_MOUSE
NC score	0.117170 (rank : 53)	θ value	0.62314 (rank : 53)
Query Neighborhood Hits	74	Target Neighborhood Hits	140	Shared Neighborhood Hits	43
SwissProt Accessions	Q9R118	Gene names	Htra1, Htra, Prss11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-).

ISK6_HUMAN
NC score	0.113275 (rank : 54)	θ value	θ > 10 (rank : 85)
Query Neighborhood Hits	74	Target Neighborhood Hits	32	Shared Neighborhood Hits	21
SwissProt Accessions	Q6UWN8, Q8N5P0	Gene names	SPINK6
Domain Architecture	No domain graphic available
Description	Serine protease inhibitor Kazal-type 6 precursor.

ISK4_MOUSE
NC score	0.111994 (rank : 55)	θ value	3.0926 (rank : 66)
Query Neighborhood Hits	74	Target Neighborhood Hits	28	Shared Neighborhood Hits	19
SwissProt Accessions	O35679	Gene names	Spink4, Mpgc60
Domain Architecture
Description	Serine protease inhibitor Kazal-type 4 precursor (Peptide PEC-60 homolog) (MPGC60 protein).

ISK5_HUMAN
NC score	0.107114 (rank : 56)	θ value	θ > 10 (rank : 84)
Query Neighborhood Hits	74	Target Neighborhood Hits	89	Shared Neighborhood Hits	30
SwissProt Accessions	Q9NQ38, O75770, Q96PP2, Q96PP3	Gene names	SPINK5
Domain Architecture
Description	Serine protease inhibitor Kazal-type 5 precursor (Lympho-epithelial Kazal-type-related inhibitor) (LEKTI) [Contains: Hemofiltrate peptide HF6478; Hemofiltrate peptide HF7665].

IBP7_HUMAN
NC score	0.106027 (rank : 57)	θ value	3.0926 (rank : 65)
Query Neighborhood Hits	74	Target Neighborhood Hits	220	Shared Neighborhood Hits	32
SwissProt Accessions	Q16270, Q07822	Gene names	IGFBP7, MAC25, PSF
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein) (Prostacyclin-stimulating factor) (PGI2-stimulating factor) (IGFBP-rP1).

HTRA1_HUMAN
NC score	0.102607 (rank : 58)	θ value	1.06291 (rank : 57)
Query Neighborhood Hits	74	Target Neighborhood Hits	155	Shared Neighborhood Hits	38
SwissProt Accessions	Q92743, Q9UNS5	Gene names	HTRA1, HTRA, PRSS11
Domain Architecture
Description	Serine protease HTRA1 precursor (EC 3.4.21.-) (L56).

ISK4_HUMAN
NC score	0.101159 (rank : 59)	θ value	θ > 10 (rank : 83)
Query Neighborhood Hits	74	Target Neighborhood Hits	28	Shared Neighborhood Hits	18
SwissProt Accessions	O60575	Gene names	SPINK4
Domain Architecture
Description	Serine protease inhibitor Kazal-type 4 precursor (Peptide PEC-60 homolog).

IBP7_MOUSE
NC score	0.097184 (rank : 60)	θ value	θ > 10 (rank : 79)
Query Neighborhood Hits	74	Target Neighborhood Hits	230	Shared Neighborhood Hits	31
SwissProt Accessions	Q61581, O88812, Q9EQW0	Gene names	Igfbp7, Mac25
Domain Architecture
Description	Insulin-like growth factor-binding protein 7 precursor (IGFBP-7) (IBP- 7) (IGF-binding protein 7) (MAC25 protein).

IPK1_HUMAN
NC score	0.086271 (rank : 61)	θ value	θ > 10 (rank : 80)
Query Neighborhood Hits	74	Target Neighborhood Hits	38	Shared Neighborhood Hits	21
SwissProt Accessions	P00995	Gene names	SPINK1, PSTI
Domain Architecture
Description	Pancreatic secretory trypsin inhibitor precursor (Tumor-associated trypsin inhibitor) (TATI) (Serine protease inhibitor Kazal-type 1).

RECK_HUMAN
NC score	0.079312 (rank : 62)	θ value	1.38821 (rank : 58)
Query Neighborhood Hits	74	Target Neighborhood Hits	189	Shared Neighborhood Hits	28
SwissProt Accessions	O95980, Q8WX37	Gene names	RECK
Domain Architecture
Description	Reversion-inducing cysteine-rich protein with Kazal motifs precursor (hRECK) (Suppressor of tumorigenicity 15) (ST15).

RECK_MOUSE
NC score	0.074886 (rank : 63)	θ value	1.38821 (rank : 59)
Query Neighborhood Hits	74	Target Neighborhood Hits	158	Shared Neighborhood Hits	27
SwissProt Accessions	Q9Z0J1	Gene names	Reck
Domain Architecture	No domain graphic available
Description	Reversion-inducing cysteine-rich protein with Kazal motifs precursor (mRECK).

ISK7_HUMAN
NC score	0.073737 (rank : 64)	θ value	θ > 10 (rank : 86)
Query Neighborhood Hits	74	Target Neighborhood Hits	31	Shared Neighborhood Hits	18
SwissProt Accessions	P58062	Gene names	SPINK7, ECG2
Domain Architecture
Description	Serine protease inhibitor Kazal-type 7 precursor (Esophagus cancer- related gene 2 protein) (ECRG-2).

ISK7_MOUSE
NC score	0.067550 (rank : 65)	θ value	θ > 10 (rank : 87)
Query Neighborhood Hits	74	Target Neighborhood Hits	28	Shared Neighborhood Hits	19
SwissProt Accessions	Q6IE32	Gene names	Spink7, Ecg2
Domain Architecture	No domain graphic available
Description	Serine protease inhibitor Kazal-type 7 precursor (Esophagus cancer- related gene 2 protein) (ECRG-2).

ISK3_MOUSE
NC score	0.062872 (rank : 66)	θ value	θ > 10 (rank : 82)
Query Neighborhood Hits	74	Target Neighborhood Hits	36	Shared Neighborhood Hits	18
SwissProt Accessions	P09036, Q5M9M3	Gene names	Spink3
Domain Architecture
Description	Serine protease inhibitor Kazal-type 3 precursor (Prostatic secretory glycoprotein) (P12).

IPK2_HUMAN
NC score	0.062596 (rank : 67)	θ value	θ > 10 (rank : 81)
Query Neighborhood Hits	74	Target Neighborhood Hits	30	Shared Neighborhood Hits	18
SwissProt Accessions	P20155	Gene names	SPINK2
Domain Architecture
Description	Serine protease inhibitor Kazal-type 2 precursor (Acrosin-trypsin inhibitor) (HUSI-II).

LRP5_HUMAN
NC score	0.059025 (rank : 68)	θ value	θ > 10 (rank : 90)
Query Neighborhood Hits	74	Target Neighborhood Hits	224	Shared Neighborhood Hits	11
SwissProt Accessions	O75197, Q96TD6, Q9UP66	Gene names	LRP5, LRP7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor.

HTRA3_HUMAN
NC score	0.058814 (rank : 69)	θ value	θ > 10 (rank : 77)
Query Neighborhood Hits	74	Target Neighborhood Hits	152	Shared Neighborhood Hits	30
SwissProt Accessions	P83110, Q7Z7A2	Gene names	HTRA3, PRSP
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease).

LRP5_MOUSE
NC score	0.058731 (rank : 70)	θ value	θ > 10 (rank : 91)
Query Neighborhood Hits	74	Target Neighborhood Hits	236	Shared Neighborhood Hits	11
SwissProt Accessions	Q91VN0, O88883, Q9R208	Gene names	Lrp5, Lrp7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 5 precursor (LRP7) (Lr3).

HTRA3_MOUSE
NC score	0.057128 (rank : 71)	θ value	θ > 10 (rank : 78)
Query Neighborhood Hits	74	Target Neighborhood Hits	156	Shared Neighborhood Hits	29
SwissProt Accessions	Q9D236, Q6WLC5, Q6YDR0	Gene names	Htra3, Prsp, Tasp
Domain Architecture
Description	Probable serine protease HTRA3 precursor (EC 3.4.21.-) (High- temperature requirement factor A3) (Pregnancy-related serine protease) (Toll-associated serine protease).

LRP6_HUMAN
NC score	0.057051 (rank : 72)	θ value	θ > 10 (rank : 92)
Query Neighborhood Hits	74	Target Neighborhood Hits	235	Shared Neighborhood Hits	9
SwissProt Accessions	O75581	Gene names	LRP6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

LRP6_MOUSE
NC score	0.056929 (rank : 73)	θ value	θ > 10 (rank : 93)
Query Neighborhood Hits	74	Target Neighborhood Hits	232	Shared Neighborhood Hits	10
SwissProt Accessions	O88572	Gene names	Lrp6
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 6 precursor.

EGF_MOUSE
NC score	0.055728 (rank : 74)	θ value	θ > 10 (rank : 76)
Query Neighborhood Hits	74	Target Neighborhood Hits	358	Shared Neighborhood Hits	13
SwissProt Accessions	P01132, Q6P9J2	Gene names	Egf
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor].

EGF_HUMAN
NC score	0.055426 (rank : 75)	θ value	θ > 10 (rank : 75)
Query Neighborhood Hits	74	Target Neighborhood Hits	343	Shared Neighborhood Hits	14
SwissProt Accessions	P01133	Gene names	EGF
Domain Architecture
Description	Pro-epidermal growth factor precursor (EGF) [Contains: Epidermal growth factor (Urogastrone)].

CO6_HUMAN
NC score	0.054000 (rank : 76)	θ value	0.0148317 (rank : 43)
Query Neighborhood Hits	74	Target Neighborhood Hits	331	Shared Neighborhood Hits	15
SwissProt Accessions	P13671	Gene names	C6
Domain Architecture
Description	Complement component C6 precursor.

LDLR_MOUSE
NC score	0.051771 (rank : 77)	θ value	θ > 10 (rank : 88)
Query Neighborhood Hits	74	Target Neighborhood Hits	382	Shared Neighborhood Hits	15
SwissProt Accessions	P35951	Gene names	Ldlr
Domain Architecture
Description	Low-density lipoprotein receptor precursor (LDL receptor).

LRP8_HUMAN
NC score	0.050827 (rank : 78)	θ value	θ > 10 (rank : 94)
Query Neighborhood Hits	74	Target Neighborhood Hits	346	Shared Neighborhood Hits	14
SwissProt Accessions	Q14114, O14968, Q86V27, Q99876, Q9BR78	Gene names	LRP8, APOER2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

LRP8_MOUSE
NC score	0.050495 (rank : 79)	θ value	θ > 10 (rank : 95)
Query Neighborhood Hits	74	Target Neighborhood Hits	385	Shared Neighborhood Hits	16
SwissProt Accessions	Q924X6, Q8CAK9, Q8CDF5, Q921B6	Gene names	Lrp8, Apoer2
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 8 precursor (Apolipoprotein E receptor 2).

LRP4_HUMAN
NC score	0.050154 (rank : 80)	θ value	θ > 10 (rank : 89)
Query Neighborhood Hits	74	Target Neighborhood Hits	355	Shared Neighborhood Hits	14
SwissProt Accessions	O75096	Gene names	LRP4, KIAA0816, MEGF7
Domain Architecture
Description	Low-density lipoprotein receptor-related protein 4 precursor (Multiple epidermal growth factor-like domains 7).

LAMB2_MOUSE
NC score	0.045173 (rank : 81)	θ value	0.813845 (rank : 56)
Query Neighborhood Hits	74	Target Neighborhood Hits	722	Shared Neighborhood Hits	23
SwissProt Accessions	Q61292, Q62182	Gene names	Lamb2, Lams
Domain Architecture
Description	Laminin beta-2 chain precursor (S-laminin) (S-LAM).

FBN3_HUMAN
NC score	0.045163 (rank : 82)	θ value	3.0926 (rank : 64)
Query Neighborhood Hits	74	Target Neighborhood Hits	543	Shared Neighborhood Hits	24
SwissProt Accessions	Q75N90, Q75N91, Q75N92, Q75N93, Q86SJ5, Q96JP8	Gene names	FBN3, KIAA1776
Domain Architecture	No domain graphic available
Description	Fibrillin-3 precursor.

FBN2_HUMAN
NC score	0.044317 (rank : 83)	θ value	3.0926 (rank : 63)
Query Neighborhood Hits	74	Target Neighborhood Hits	560	Shared Neighborhood Hits	25
SwissProt Accessions	P35556	Gene names	FBN2
Domain Architecture
Description	Fibrillin-2 precursor.

CFAI_MOUSE
NC score	0.040249 (rank : 84)	θ value	0.00869519 (rank : 39)
Query Neighborhood Hits	74	Target Neighborhood Hits	290	Shared Neighborhood Hits	20
SwissProt Accessions	Q61129, Q9WU07	Gene names	Cfi, If
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

LCE2D_HUMAN
NC score	0.037593 (rank : 85)	θ value	5.27518 (rank : 68)
Query Neighborhood Hits	74	Target Neighborhood Hits	50	Shared Neighborhood Hits	5
SwissProt Accessions	Q5TA82	Gene names	LCE2D, LEP12, SPRL1A
Domain Architecture	No domain graphic available
Description	Late cornified envelope protein 2D (Late envelope protein 12) (Small proline-rich-like epidermal differentiation complex protein 1A).

LAMB3_HUMAN
NC score	0.033214 (rank : 86)	θ value	0.62314 (rank : 54)
Query Neighborhood Hits	74	Target Neighborhood Hits	461	Shared Neighborhood Hits	14
SwissProt Accessions	Q13751, O14947, Q14733, Q9UJK4, Q9UJL1	Gene names	LAMB3
Domain Architecture
Description	Laminin beta-3 chain precursor (Laminin 5 beta 3) (Laminin B1k chain) (Kalinin B1 chain).

MAML1_HUMAN
NC score	0.031903 (rank : 87)	θ value	1.81305 (rank : 60)
Query Neighborhood Hits	74	Target Neighborhood Hits	228	Shared Neighborhood Hits	3
SwissProt Accessions	Q92585, Q9NZ12	Gene names	MAML1, KIAA0200
Domain Architecture	No domain graphic available
Description	Mastermind-like protein 1 (Mam-1).

LAMB1_MOUSE
NC score	0.029232 (rank : 88)	θ value	8.99809 (rank : 72)
Query Neighborhood Hits	74	Target Neighborhood Hits	919	Shared Neighborhood Hits	18
SwissProt Accessions	P02469	Gene names	Lamb1-1, Lamb-1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

LAMB3_MOUSE
NC score	0.027635 (rank : 89)	θ value	5.27518 (rank : 67)
Query Neighborhood Hits	74	Target Neighborhood Hits	444	Shared Neighborhood Hits	15
SwissProt Accessions	Q61087	Gene names	Lamb3
Domain Architecture
Description	Laminin beta-3 chain precursor (Laminin 5 beta 3) (Kalinin B1 chain).

LAMB1_HUMAN
NC score	0.025691 (rank : 90)	θ value	8.99809 (rank : 71)
Query Neighborhood Hits	74	Target Neighborhood Hits	1018	Shared Neighborhood Hits	17
SwissProt Accessions	P07942	Gene names	LAMB1
Domain Architecture
Description	Laminin beta-1 chain precursor (Laminin B1 chain).

U383_HUMAN
NC score	0.016649 (rank : 91)	θ value	8.99809 (rank : 73)
Query Neighborhood Hits	74	Target Neighborhood Hits	23	Shared Neighborhood Hits	3
SwissProt Accessions	Q8IYL2	Gene names	C4orf23
Domain Architecture	No domain graphic available
Description	Putative methyltransferase UPF0383 (EC 2.1.1.-).

CFAI_HUMAN
NC score	0.015069 (rank : 92)	θ value	3.0926 (rank : 62)
Query Neighborhood Hits	74	Target Neighborhood Hits	289	Shared Neighborhood Hits	12
SwissProt Accessions	P05156, O60442	Gene names	CFI, IF
Domain Architecture
Description	Complement factor I precursor (EC 3.4.21.45) (C3B/C4B inactivator) [Contains: Complement factor I heavy chain; Complement factor I light chain].

GP107_HUMAN
NC score	0.008208 (rank : 93)	θ value	8.99809 (rank : 70)
Query Neighborhood Hits	74	Target Neighborhood Hits	18	Shared Neighborhood Hits	2
SwissProt Accessions	Q5VW38, Q5JPA3, Q5VW39, Q96T26, Q9H658, Q9HCE8	Gene names	GPR107, KIAA1624, LUSTR1
Domain Architecture	No domain graphic available
Description	Protein GPR107 precursor (Lung seven transmembrane receptor 1).

PDE4D_HUMAN
NC score	0.003785 (rank : 94)	θ value	6.88961 (rank : 69)
Query Neighborhood Hits	74	Target Neighborhood Hits	122	Shared Neighborhood Hits	2
SwissProt Accessions	Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7	Gene names	PDE4D
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).

ZN553_MOUSE
NC score	-0.003614 (rank : 95)	θ value	8.99809 (rank : 74)
Query Neighborhood Hits	74	Target Neighborhood Hits	744	Shared Neighborhood Hits	3
SwissProt Accessions	Q3US17, Q3UFP3, Q8R0V0, Q921H7	Gene names	Znf553, Zfp553
Domain Architecture	No domain graphic available
Description	Zinc finger protein 553.