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Network neighborhood for query Sequence : PDE4A_MOUSE

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PDE4A_MOUSE
SwissProt Accessions	O89084, Q8R078, Q9JHQ4, Q9QX48, Q9QX49, Q9QXI8	Gene names	Pde4a
Domain Architecture
Description	cAMP-dependent 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

PDE4A_HUMAN
θ value	0 (rank : 1)	NC score	0.997893 (rank : 2)
Query Neighborhood Hits	66	Target Neighborhood Hits	73	Shared Neighborhood Hits	47
SwissProt Accessions	P27815, O75522, O76092, Q16255, Q16691, Q8WUQ3	Gene names	PDE4A
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).

PDE4A_MOUSE
θ value	0 (rank : 2)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	66	Target Neighborhood Hits	66	Shared Neighborhood Hits	66
SwissProt Accessions	O89084, Q8R078, Q9JHQ4, Q9QX48, Q9QX49, Q9QXI8	Gene names	Pde4a
Domain Architecture
Description	cAMP-dependent 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17).

PDE4B_HUMAN
θ value	0 (rank : 3)	NC score	0.996109 (rank : 3)
Query Neighborhood Hits	66	Target Neighborhood Hits	65	Shared Neighborhood Hits	38
SwissProt Accessions	Q07343, O15443	Gene names	PDE4B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32).

PDE4C_HUMAN
θ value	0 (rank : 4)	NC score	0.995975 (rank : 4)
Query Neighborhood Hits	66	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	Q08493, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6	Gene names	PDE4C
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17) (DPDE1) (PDE21).

PDE4C_MOUSE
θ value	0 (rank : 5)	NC score	0.995682 (rank : 5)
Query Neighborhood Hits	66	Target Neighborhood Hits	60	Shared Neighborhood Hits	40
SwissProt Accessions	Q3UEI1, Q8K0P4	Gene names	Pde4c
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17).

PDE4D_HUMAN
θ value	0 (rank : 6)	NC score	0.994999 (rank : 7)
Query Neighborhood Hits	66	Target Neighborhood Hits	122	Shared Neighborhood Hits	42
SwissProt Accessions	Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7	Gene names	PDE4D
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).

PDE4D_MOUSE
θ value	0 (rank : 7)	NC score	0.995319 (rank : 6)
Query Neighborhood Hits	66	Target Neighborhood Hits	98	Shared Neighborhood Hits	41
SwissProt Accessions	Q01063, Q6TRH9, Q8C4Q7, Q8CG05	Gene names	Pde4d
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3).

PDE1A_HUMAN
θ value	7.47731e-63 (rank : 8)	NC score	0.933534 (rank : 14)
Query Neighborhood Hits	66	Target Neighborhood Hits	42	Shared Neighborhood Hits	38
SwissProt Accessions	P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3	Gene names	PDE1A
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1).

PDE1A_MOUSE
θ value	2.17557e-62 (rank : 9)	NC score	0.933825 (rank : 12)
Query Neighborhood Hits	66	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	Q61481, O35388	Gene names	Pde1a
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE).

PDE1C_HUMAN
θ value	8.26713e-62 (rank : 10)	NC score	0.923420 (rank : 17)
Query Neighborhood Hits	66	Target Neighborhood Hits	134	Shared Neighborhood Hits	39
SwissProt Accessions	Q14123, Q14124	Gene names	PDE1C
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).

PDE1C_MOUSE
θ value	2.40537e-61 (rank : 11)	NC score	0.922468 (rank : 19)
Query Neighborhood Hits	66	Target Neighborhood Hits	161	Shared Neighborhood Hits	39
SwissProt Accessions	Q64338, Q62045, Q8BSV6	Gene names	Pde1c
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C).

PDE1B_MOUSE
θ value	1.61343e-57 (rank : 12)	NC score	0.933595 (rank : 13)
Query Neighborhood Hits	66	Target Neighborhood Hits	46	Shared Neighborhood Hits	38
SwissProt Accessions	Q01065, O35384	Gene names	Pde1b, Pde1b1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE1B_HUMAN
θ value	3.974e-56 (rank : 13)	NC score	0.931800 (rank : 15)
Query Neighborhood Hits	66	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q01064, Q92825	Gene names	PDE1B, PDE1B1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE8A_HUMAN
θ value	3.974e-56 (rank : 14)	NC score	0.923425 (rank : 16)
Query Neighborhood Hits	66	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O60658, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q9UMB7	Gene names	PDE8A
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17).

PDE7A_HUMAN
θ value	3.36421e-55 (rank : 15)	NC score	0.936601 (rank : 10)
Query Neighborhood Hits	66	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	Q13946, O15380	Gene names	PDE7A
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (HCP1) (TM22).

PDE7B_MOUSE
θ value	4.39379e-55 (rank : 16)	NC score	0.938072 (rank : 8)
Query Neighborhood Hits	66	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXQ1	Gene names	Pde7b
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE8B_HUMAN
θ value	1.2784e-54 (rank : 17)	NC score	0.921651 (rank : 20)
Query Neighborhood Hits	66	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O95263, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2	Gene names	PDE8B
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (EC 3.1.4.17) (HSPDE8B).

PDE7B_HUMAN
θ value	3.71957e-54 (rank : 18)	NC score	0.937929 (rank : 9)
Query Neighborhood Hits	66	Target Neighborhood Hits	43	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP56	Gene names	PDE7B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE7A_MOUSE
θ value	3.48141e-52 (rank : 19)	NC score	0.935740 (rank : 11)
Query Neighborhood Hits	66	Target Neighborhood Hits	39	Shared Neighborhood Hits	38
SwissProt Accessions	P70453, Q9ERB3	Gene names	Pde7a
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (P2A).

PDE8A_MOUSE
θ value	8.02596e-49 (rank : 20)	NC score	0.917837 (rank : 22)
Query Neighborhood Hits	66	Target Neighborhood Hits	52	Shared Neighborhood Hits	38
SwissProt Accessions	O88502	Gene names	Pde8a, Pde8
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17) (MMPDE8).

PDE3B_HUMAN
θ value	2.18568e-46 (rank : 21)	NC score	0.908990 (rank : 23)
Query Neighborhood Hits	66	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q13370, O00639, Q14408	Gene names	PDE3B
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1).

PDE9A_HUMAN
θ value	3.48949e-44 (rank : 22)	NC score	0.919635 (rank : 21)
Query Neighborhood Hits	66	Target Neighborhood Hits	93	Shared Neighborhood Hits	38
SwissProt Accessions	O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0	Gene names	PDE9A
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE9A_MOUSE
θ value	1.73182e-43 (rank : 23)	NC score	0.922923 (rank : 18)
Query Neighborhood Hits	66	Target Neighborhood Hits	72	Shared Neighborhood Hits	38
SwissProt Accessions	O70628	Gene names	Pde9a, Pde8b
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE3A_HUMAN
θ value	6.58091e-43 (rank : 24)	NC score	0.893722 (rank : 24)
Query Neighborhood Hits	66	Target Neighborhood Hits	79	Shared Neighborhood Hits	39
SwissProt Accessions	Q14432, O60865, Q13348	Gene names	PDE3A
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE3A_MOUSE
θ value	2.50074e-42 (rank : 25)	NC score	0.891369 (rank : 25)
Query Neighborhood Hits	66	Target Neighborhood Hits	115	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Z0X4	Gene names	Pde3a
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE6A_HUMAN
θ value	1.24399e-33 (rank : 26)	NC score	0.805203 (rank : 35)
Query Neighborhood Hits	66	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	P16499	Gene names	PDE6A, PDEA
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1).

PDE6C_HUMAN
θ value	2.77131e-33 (rank : 27)	NC score	0.806643 (rank : 34)
Query Neighborhood Hits	66	Target Neighborhood Hits	56	Shared Neighborhood Hits	39
SwissProt Accessions	P51160, Q5VY29	Gene names	PDE6C, PDEA2
Domain Architecture
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6B_HUMAN
θ value	8.06329e-33 (rank : 28)	NC score	0.800988 (rank : 37)
Query Neighborhood Hits	66	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	P35913, Q9BWH5	Gene names	PDE6B, PDEB
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta-subunit precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE6C_MOUSE
θ value	1.0531e-32 (rank : 29)	NC score	0.807131 (rank : 33)
Query Neighborhood Hits	66	Target Neighborhood Hits	45	Shared Neighborhood Hits	39
SwissProt Accessions	Q91ZQ1, Q8R0D4	Gene names	Pde6c
Domain Architecture	No domain graphic available
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE11_HUMAN
θ value	2.34606e-32 (rank : 30)	NC score	0.831411 (rank : 28)
Query Neighborhood Hits	66	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HCR9, Q53T16, Q96S76, Q9GZY7, Q9HB46, Q9NY45	Gene names	PDE11A
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE6A_MOUSE
θ value	2.34606e-32 (rank : 31)	NC score	0.801108 (rank : 36)
Query Neighborhood Hits	66	Target Neighborhood Hits	45	Shared Neighborhood Hits	39
SwissProt Accessions	P27664	Gene names	Pde6a, Mpa, Pdea
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha).

PDE11_MOUSE
θ value	3.06405e-32 (rank : 32)	NC score	0.831239 (rank : 30)
Query Neighborhood Hits	66	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	P0C1Q2	Gene names	Pde11a
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE2A_MOUSE
θ value	3.06405e-32 (rank : 33)	NC score	0.852116 (rank : 26)
Query Neighborhood Hits	66	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q922S4, Q8K2U1	Gene names	Pde2a
Domain Architecture	No domain graphic available
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE6B_MOUSE
θ value	3.06405e-32 (rank : 34)	NC score	0.799068 (rank : 38)
Query Neighborhood Hits	66	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	P23440	Gene names	Pde6b, Mpb, Pdeb, rd
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE2A_HUMAN
θ value	4.00176e-32 (rank : 35)	NC score	0.851186 (rank : 27)
Query Neighborhood Hits	66	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O00408	Gene names	PDE2A
Domain Architecture
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE5A_MOUSE
θ value	2.05525e-28 (rank : 36)	NC score	0.814771 (rank : 31)
Query Neighborhood Hits	66	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CG03	Gene names	Pde5a, Pde5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE10_HUMAN
θ value	6.61148e-27 (rank : 37)	NC score	0.831271 (rank : 29)
Query Neighborhood Hits	66	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y233, Q9Y5T1	Gene names	PDE10A
Domain Architecture
Description	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17).

PDE5A_HUMAN
θ value	2.77775e-25 (rank : 38)	NC score	0.810984 (rank : 32)
Query Neighborhood Hits	66	Target Neighborhood Hits	48	Shared Neighborhood Hits	38
SwissProt Accessions	O76074, O75026, O75887, Q86UI0, Q86V66, Q9Y6Z6	Gene names	PDE5A, PDE5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

NEST_HUMAN
θ value	0.00102713 (rank : 39)	NC score	0.013983 (rank : 46)
Query Neighborhood Hits	66	Target Neighborhood Hits	1305	Shared Neighborhood Hits	10
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

PRDM2_HUMAN
θ value	0.813845 (rank : 40)	NC score	0.003883 (rank : 58)
Query Neighborhood Hits	66	Target Neighborhood Hits	1135	Shared Neighborhood Hits	12
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

LBXCO_MOUSE
θ value	1.06291 (rank : 41)	NC score	0.023429 (rank : 39)
Query Neighborhood Hits	66	Target Neighborhood Hits	140	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BX46, Q3UYA4, Q5W8I2, Q8C0T2	Gene names	Lbxcor1, Corl1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1 (Transcriptional corepressor Corl1).

VGLL4_MOUSE
θ value	1.38821 (rank : 42)	NC score	0.022064 (rank : 40)
Query Neighborhood Hits	66	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q80V24	Gene names	Vgll4
Domain Architecture	No domain graphic available
Description	Transcription cofactor vestigial-like protein 4 (Vgl-4).

JPH2_HUMAN
θ value	1.81305 (rank : 43)	NC score	0.006472 (rank : 51)
Query Neighborhood Hits	66	Target Neighborhood Hits	639	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

LBXCO_HUMAN
θ value	1.81305 (rank : 44)	NC score	0.021010 (rank : 41)
Query Neighborhood Hits	66	Target Neighborhood Hits	167	Shared Neighborhood Hits	5
SwissProt Accessions	P84550	Gene names	LBXCOR1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1.

TNT_HUMAN
θ value	3.0926 (rank : 45)	NC score	0.019024 (rank : 42)
Query Neighborhood Hits	66	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q7Z2V1, Q8NEF0	Gene names
Domain Architecture	No domain graphic available
Description	Protein TNT.

UBP34_HUMAN
θ value	3.0926 (rank : 46)	NC score	0.008476 (rank : 49)
Query Neighborhood Hits	66	Target Neighborhood Hits	210	Shared Neighborhood Hits	4
SwissProt Accessions	Q70CQ2, O60316, O94834, Q3B777, Q6P6C9, Q7L8P6, Q8N3T9, Q8TBW2, Q9UGA1	Gene names	USP34, KIAA0570, KIAA0729
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

ZIC2_MOUSE
θ value	3.0926 (rank : 47)	NC score	-0.003946 (rank : 66)
Query Neighborhood Hits	66	Target Neighborhood Hits	727	Shared Neighborhood Hits	3
SwissProt Accessions	Q62520	Gene names	Zic2
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZIC 2 (Zinc finger protein of the cerebellum 2).

ABCA2_HUMAN
θ value	4.03905 (rank : 48)	NC score	0.002101 (rank : 61)
Query Neighborhood Hits	66	Target Neighborhood Hits	143	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BZC7	Gene names	ABCA2, ABC2
Domain Architecture
Description	ATP-binding cassette sub-family A member 2 (ATP-binding cassette transporter 2) (ATP-binding cassette 2).

SRRM2_MOUSE
θ value	4.03905 (rank : 49)	NC score	0.007634 (rank : 50)
Query Neighborhood Hits	66	Target Neighborhood Hits	1470	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

T22D4_HUMAN
θ value	4.03905 (rank : 50)	NC score	0.005592 (rank : 52)
Query Neighborhood Hits	66	Target Neighborhood Hits	403	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y3Q8	Gene names	TSC22D4, TILZ2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1).

CF059_HUMAN
θ value	5.27518 (rank : 51)	NC score	0.014519 (rank : 45)
Query Neighborhood Hits	66	Target Neighborhood Hits	2	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H0P7, Q2M1M7, Q5TEF2, Q9H5S5	Gene names	C6orf59
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf59.

CTND1_MOUSE
θ value	5.27518 (rank : 52)	NC score	0.005162 (rank : 53)
Query Neighborhood Hits	66	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	P30999	Gene names	Ctnnd1, Catns
Domain Architecture
Description	Catenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Src substrate) (CAS) (p120(cas)).

FARP1_HUMAN
θ value	5.27518 (rank : 53)	NC score	0.004105 (rank : 56)
Query Neighborhood Hits	66	Target Neighborhood Hits	241	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

FBXL6_MOUSE
θ value	5.27518 (rank : 54)	NC score	0.009499 (rank : 48)
Query Neighborhood Hits	66	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QXW0, Q9JJD7	Gene names	Fbxl6, Fbl6
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 6 (F-box and leucine-rich repeat protein 6) (F-box protein FBL6).

K1794_HUMAN
θ value	5.27518 (rank : 55)	NC score	0.017112 (rank : 44)
Query Neighborhood Hits	66	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NVI1, Q96JN1, Q96ST0, Q9BT96	Gene names	KIAA1794
Domain Architecture	No domain graphic available
Description	Protein KIAA1794.

NCOA6_HUMAN
θ value	5.27518 (rank : 56)	NC score	0.002621 (rank : 59)
Query Neighborhood Hits	66	Target Neighborhood Hits	1202	Shared Neighborhood Hits	9
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

ZO2_MOUSE
θ value	5.27518 (rank : 57)	NC score	0.002094 (rank : 62)
Query Neighborhood Hits	66	Target Neighborhood Hits	296	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

MITF_MOUSE
θ value	6.88961 (rank : 58)	NC score	0.004082 (rank : 57)
Query Neighborhood Hits	66	Target Neighborhood Hits	115	Shared Neighborhood Hits	2
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

TP53B_HUMAN
θ value	6.88961 (rank : 59)	NC score	0.011258 (rank : 47)
Query Neighborhood Hits	66	Target Neighborhood Hits	413	Shared Neighborhood Hits	7
SwissProt Accessions	Q12888, Q2M1Z7, Q4LE46, Q5FWZ3, Q7Z3U4	Gene names	TP53BP1
Domain Architecture
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

ACCN4_HUMAN
θ value	8.99809 (rank : 60)	NC score	0.002510 (rank : 60)
Query Neighborhood Hits	66	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q96FT7, Q53SB7, Q6GMS1, Q6PIN9, Q9NQA4	Gene names	ACCN4, ASIC4
Domain Architecture	No domain graphic available
Description	Amiloride-sensitive cation channel 4 (Amiloride-sensitive cation channel 4, pituitary) (Acid-sensing ion channel 4).

CE025_HUMAN
θ value	8.99809 (rank : 61)	NC score	0.017240 (rank : 43)
Query Neighborhood Hits	66	Target Neighborhood Hits	114	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NDZ2, Q6NXN8, Q6ZTU4, Q8IZ15	Gene names	C5orf25
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C5orf25.

CTND1_HUMAN
θ value	8.99809 (rank : 62)	NC score	0.004436 (rank : 55)
Query Neighborhood Hits	66	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	O60716, O15088, O60713, O60714, O60715, O60935, Q6RBX8, Q9UP71, Q9UP72, Q9UP73	Gene names	CTNND1, KIAA0384
Domain Architecture
Description	Catenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Src substrate) (CAS) (p120(cas)).

CUTL1_MOUSE
θ value	8.99809 (rank : 63)	NC score	-0.001027 (rank : 64)
Query Neighborhood Hits	66	Target Neighborhood Hits	1620	Shared Neighborhood Hits	11
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

KIF4A_HUMAN
θ value	8.99809 (rank : 64)	NC score	-0.001691 (rank : 65)
Query Neighborhood Hits	66	Target Neighborhood Hits	1159	Shared Neighborhood Hits	6
SwissProt Accessions	O95239, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3	Gene names	KIF4A, KIF4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

KIF4A_MOUSE
θ value	8.99809 (rank : 65)	NC score	-0.000984 (rank : 63)
Query Neighborhood Hits	66	Target Neighborhood Hits	1033	Shared Neighborhood Hits	7
SwissProt Accessions	P33174	Gene names	Kif4a, Kif4, Kns4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

LIX1L_HUMAN
θ value	8.99809 (rank : 66)	NC score	0.004635 (rank : 54)
Query Neighborhood Hits	66	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IVB5, Q6AI36	Gene names	LIX1L
Domain Architecture	No domain graphic available
Description	LIX1-like protein.

Hits sorted by NC score

PDE4A_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 2)
Query Neighborhood Hits	66	Target Neighborhood Hits	66	Shared Neighborhood Hits	66
SwissProt Accessions	O89084, Q8R078, Q9JHQ4, Q9QX48, Q9QX49, Q9QXI8	Gene names	Pde4a
Domain Architecture
Description	cAMP-dependent 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17).

PDE4A_HUMAN
NC score	0.997893 (rank : 2)	θ value	0 (rank : 1)
Query Neighborhood Hits	66	Target Neighborhood Hits	73	Shared Neighborhood Hits	47
SwissProt Accessions	P27815, O75522, O76092, Q16255, Q16691, Q8WUQ3	Gene names	PDE4A
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4A (EC 3.1.4.17) (DPDE2) (PDE46).

PDE4B_HUMAN
NC score	0.996109 (rank : 3)	θ value	0 (rank : 3)
Query Neighborhood Hits	66	Target Neighborhood Hits	65	Shared Neighborhood Hits	38
SwissProt Accessions	Q07343, O15443	Gene names	PDE4B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.17) (DPDE4) (PDE32).

PDE4C_HUMAN
NC score	0.995975 (rank : 4)	θ value	0 (rank : 4)
Query Neighborhood Hits	66	Target Neighborhood Hits	56	Shared Neighborhood Hits	38
SwissProt Accessions	Q08493, Q9UN44, Q9UN45, Q9UN46, Q9UPJ6	Gene names	PDE4C
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17) (DPDE1) (PDE21).

PDE4C_MOUSE
NC score	0.995682 (rank : 5)	θ value	0 (rank : 5)
Query Neighborhood Hits	66	Target Neighborhood Hits	60	Shared Neighborhood Hits	40
SwissProt Accessions	Q3UEI1, Q8K0P4	Gene names	Pde4c
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.17).

PDE4D_MOUSE
NC score	0.995319 (rank : 6)	θ value	0 (rank : 7)
Query Neighborhood Hits	66	Target Neighborhood Hits	98	Shared Neighborhood Hits	41
SwissProt Accessions	Q01063, Q6TRH9, Q8C4Q7, Q8CG05	Gene names	Pde4d
Domain Architecture	No domain graphic available
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3).

PDE4D_HUMAN
NC score	0.994999 (rank : 7)	θ value	0 (rank : 6)
Query Neighborhood Hits	66	Target Neighborhood Hits	122	Shared Neighborhood Hits	42
SwissProt Accessions	Q08499, O43433, Q13549, Q13550, Q13551, Q7Z2L8, Q8IV84, Q8IVA9, Q8IVD2, Q8IVD3, Q9HCX7	Gene names	PDE4D
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.17) (DPDE3) (PDE43).

PDE7B_MOUSE
NC score	0.938072 (rank : 8)	θ value	4.39379e-55 (rank : 16)
Query Neighborhood Hits	66	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	Q9QXQ1	Gene names	Pde7b
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE7B_HUMAN
NC score	0.937929 (rank : 9)	θ value	3.71957e-54 (rank : 18)
Query Neighborhood Hits	66	Target Neighborhood Hits	43	Shared Neighborhood Hits	38
SwissProt Accessions	Q9NP56	Gene names	PDE7B
Domain Architecture
Description	cAMP-specific 3',5'-cyclic phosphodiesterase 7B (EC 3.1.4.17).

PDE7A_HUMAN
NC score	0.936601 (rank : 10)	θ value	3.36421e-55 (rank : 15)
Query Neighborhood Hits	66	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	Q13946, O15380	Gene names	PDE7A
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (HCP1) (TM22).

PDE7A_MOUSE
NC score	0.935740 (rank : 11)	θ value	3.48141e-52 (rank : 19)
Query Neighborhood Hits	66	Target Neighborhood Hits	39	Shared Neighborhood Hits	38
SwissProt Accessions	P70453, Q9ERB3	Gene names	Pde7a
Domain Architecture
Description	High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (EC 3.1.4.17) (P2A).

PDE1A_MOUSE
NC score	0.933825 (rank : 12)	θ value	2.17557e-62 (rank : 9)
Query Neighborhood Hits	66	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	Q61481, O35388	Gene names	Pde1a
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE).

PDE1B_MOUSE
NC score	0.933595 (rank : 13)	θ value	1.61343e-57 (rank : 12)
Query Neighborhood Hits	66	Target Neighborhood Hits	46	Shared Neighborhood Hits	38
SwissProt Accessions	Q01065, O35384	Gene names	Pde1b, Pde1b1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE1A_HUMAN
NC score	0.933534 (rank : 14)	θ value	7.47731e-63 (rank : 8)
Query Neighborhood Hits	66	Target Neighborhood Hits	42	Shared Neighborhood Hits	38
SwissProt Accessions	P54750, Q86VZ0, Q9C0K8, Q9C0K9, Q9C0L0, Q9C0L1, Q9C0L2, Q9C0L3, Q9C0L4, Q9UFX3	Gene names	PDE1A
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (EC 3.1.4.17) (Cam-PDE 1A) (61 kDa Cam-PDE) (hCam-1).

PDE1B_HUMAN
NC score	0.931800 (rank : 15)	θ value	3.974e-56 (rank : 13)
Query Neighborhood Hits	66	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q01064, Q92825	Gene names	PDE1B, PDE1B1
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (EC 3.1.4.17) (Cam-PDE 1B) (63 kDa Cam-PDE).

PDE8A_HUMAN
NC score	0.923425 (rank : 16)	θ value	3.974e-56 (rank : 14)
Query Neighborhood Hits	66	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O60658, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q9UMB7	Gene names	PDE8A
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17).

PDE1C_HUMAN
NC score	0.923420 (rank : 17)	θ value	8.26713e-62 (rank : 10)
Query Neighborhood Hits	66	Target Neighborhood Hits	134	Shared Neighborhood Hits	39
SwissProt Accessions	Q14123, Q14124	Gene names	PDE1C
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C) (hCam-3).

PDE9A_MOUSE
NC score	0.922923 (rank : 18)	θ value	1.73182e-43 (rank : 23)
Query Neighborhood Hits	66	Target Neighborhood Hits	72	Shared Neighborhood Hits	38
SwissProt Accessions	O70628	Gene names	Pde9a, Pde8b
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE1C_MOUSE
NC score	0.922468 (rank : 19)	θ value	2.40537e-61 (rank : 11)
Query Neighborhood Hits	66	Target Neighborhood Hits	161	Shared Neighborhood Hits	39
SwissProt Accessions	Q64338, Q62045, Q8BSV6	Gene names	Pde1c
Domain Architecture
Description	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (EC 3.1.4.17) (Cam-PDE 1C).

PDE8B_HUMAN
NC score	0.921651 (rank : 20)	θ value	1.2784e-54 (rank : 17)
Query Neighborhood Hits	66	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O95263, Q86XK8, Q8IUJ7, Q8IUJ8, Q8IUJ9, Q8IUK0, Q8N3T2	Gene names	PDE8B
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (EC 3.1.4.17) (HSPDE8B).

PDE9A_HUMAN
NC score	0.919635 (rank : 21)	θ value	3.48949e-44 (rank : 22)
Query Neighborhood Hits	66	Target Neighborhood Hits	93	Shared Neighborhood Hits	38
SwissProt Accessions	O76083, O75490, O75491, O95225, Q86SF7, Q86SI6, Q86SJ3, Q86WN3, Q86WN4, Q86WN5, Q86WN6, Q86WN7, Q86WN8, Q86WN9, Q86WP0	Gene names	PDE9A
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

PDE8A_MOUSE
NC score	0.917837 (rank : 22)	θ value	8.02596e-49 (rank : 20)
Query Neighborhood Hits	66	Target Neighborhood Hits	52	Shared Neighborhood Hits	38
SwissProt Accessions	O88502	Gene names	Pde8a, Pde8
Domain Architecture
Description	High-affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.17) (MMPDE8).

PDE3B_HUMAN
NC score	0.908990 (rank : 23)	θ value	2.18568e-46 (rank : 21)
Query Neighborhood Hits	66	Target Neighborhood Hits	60	Shared Neighborhood Hits	38
SwissProt Accessions	Q13370, O00639, Q14408	Gene names	PDE3B
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase B (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase B) (CGI-PDE B) (CGIPDE1) (CGIP1).

PDE3A_HUMAN
NC score	0.893722 (rank : 24)	θ value	6.58091e-43 (rank : 24)
Query Neighborhood Hits	66	Target Neighborhood Hits	79	Shared Neighborhood Hits	39
SwissProt Accessions	Q14432, O60865, Q13348	Gene names	PDE3A
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE3A_MOUSE
NC score	0.891369 (rank : 25)	θ value	2.50074e-42 (rank : 25)
Query Neighborhood Hits	66	Target Neighborhood Hits	115	Shared Neighborhood Hits	41
SwissProt Accessions	Q9Z0X4	Gene names	Pde3a
Domain Architecture
Description	cGMP-inhibited 3',5'-cyclic phosphodiesterase A (EC 3.1.4.17) (Cyclic GMP-inhibited phosphodiesterase A) (CGI-PDE A).

PDE2A_MOUSE
NC score	0.852116 (rank : 26)	θ value	3.06405e-32 (rank : 33)
Query Neighborhood Hits	66	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q922S4, Q8K2U1	Gene names	Pde2a
Domain Architecture	No domain graphic available
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE2A_HUMAN
NC score	0.851186 (rank : 27)	θ value	4.00176e-32 (rank : 35)
Query Neighborhood Hits	66	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	O00408	Gene names	PDE2A
Domain Architecture
Description	cGMP-dependent 3',5'-cyclic phosphodiesterase (EC 3.1.4.17) (Cyclic GMP-stimulated phosphodiesterase) (CGS-PDE) (cGSPDE).

PDE11_HUMAN
NC score	0.831411 (rank : 28)	θ value	2.34606e-32 (rank : 30)
Query Neighborhood Hits	66	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9HCR9, Q53T16, Q96S76, Q9GZY7, Q9HB46, Q9NY45	Gene names	PDE11A
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE10_HUMAN
NC score	0.831271 (rank : 29)	θ value	6.61148e-27 (rank : 37)
Query Neighborhood Hits	66	Target Neighborhood Hits	49	Shared Neighborhood Hits	38
SwissProt Accessions	Q9Y233, Q9Y5T1	Gene names	PDE10A
Domain Architecture
Description	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (EC 3.1.4.17).

PDE11_MOUSE
NC score	0.831239 (rank : 30)	θ value	3.06405e-32 (rank : 32)
Query Neighborhood Hits	66	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	P0C1Q2	Gene names	Pde11a
Domain Architecture	No domain graphic available
Description	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (EC 3.1.4.17) (EC 3.1.4.35) (cAMP and cGMP phosphodiesterase 11A).

PDE5A_MOUSE
NC score	0.814771 (rank : 31)	θ value	2.05525e-28 (rank : 36)
Query Neighborhood Hits	66	Target Neighborhood Hits	50	Shared Neighborhood Hits	38
SwissProt Accessions	Q8CG03	Gene names	Pde5a, Pde5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE5A_HUMAN
NC score	0.810984 (rank : 32)	θ value	2.77775e-25 (rank : 38)
Query Neighborhood Hits	66	Target Neighborhood Hits	48	Shared Neighborhood Hits	38
SwissProt Accessions	O76074, O75026, O75887, Q86UI0, Q86V66, Q9Y6Z6	Gene names	PDE5A, PDE5
Domain Architecture
Description	cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (CGB-PDE) (cGMP-binding cGMP-specific phosphodiesterase).

PDE6C_MOUSE
NC score	0.807131 (rank : 33)	θ value	1.0531e-32 (rank : 29)
Query Neighborhood Hits	66	Target Neighborhood Hits	45	Shared Neighborhood Hits	39
SwissProt Accessions	Q91ZQ1, Q8R0D4	Gene names	Pde6c
Domain Architecture	No domain graphic available
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6C_HUMAN
NC score	0.806643 (rank : 34)	θ value	2.77131e-33 (rank : 27)
Query Neighborhood Hits	66	Target Neighborhood Hits	56	Shared Neighborhood Hits	39
SwissProt Accessions	P51160, Q5VY29	Gene names	PDE6C, PDEA2
Domain Architecture
Description	Cone cGMP-specific 3',5'-cyclic phosphodiesterase alpha'-subunit (EC 3.1.4.35) (cGMP phosphodiesterase 6C).

PDE6A_HUMAN
NC score	0.805203 (rank : 35)	θ value	1.24399e-33 (rank : 26)
Query Neighborhood Hits	66	Target Neighborhood Hits	47	Shared Neighborhood Hits	38
SwissProt Accessions	P16499	Gene names	PDE6A, PDEA
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha) (PDE V-B1).

PDE6A_MOUSE
NC score	0.801108 (rank : 36)	θ value	2.34606e-32 (rank : 31)
Query Neighborhood Hits	66	Target Neighborhood Hits	45	Shared Neighborhood Hits	39
SwissProt Accessions	P27664	Gene names	Pde6a, Mpa, Pdea
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase alpha-subunit (EC 3.1.4.35) (GMP-PDE alpha).

PDE6B_HUMAN
NC score	0.800988 (rank : 37)	θ value	8.06329e-33 (rank : 28)
Query Neighborhood Hits	66	Target Neighborhood Hits	44	Shared Neighborhood Hits	38
SwissProt Accessions	P35913, Q9BWH5	Gene names	PDE6B, PDEB
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase beta-subunit precursor (EC 3.1.4.35) (GMP-PDE beta).

PDE6B_MOUSE
NC score	0.799068 (rank : 38)	θ value	3.06405e-32 (rank : 34)
Query Neighborhood Hits	66	Target Neighborhood Hits	41	Shared Neighborhood Hits	38
SwissProt Accessions	P23440	Gene names	Pde6b, Mpb, Pdeb, rd
Domain Architecture
Description	Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta precursor (EC 3.1.4.35) (GMP-PDE beta).

LBXCO_MOUSE
NC score	0.023429 (rank : 39)	θ value	1.06291 (rank : 41)
Query Neighborhood Hits	66	Target Neighborhood Hits	140	Shared Neighborhood Hits	4
SwissProt Accessions	Q8BX46, Q3UYA4, Q5W8I2, Q8C0T2	Gene names	Lbxcor1, Corl1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1 (Transcriptional corepressor Corl1).

VGLL4_MOUSE
NC score	0.022064 (rank : 40)	θ value	1.38821 (rank : 42)
Query Neighborhood Hits	66	Target Neighborhood Hits	16	Shared Neighborhood Hits	3
SwissProt Accessions	Q80V24	Gene names	Vgll4
Domain Architecture	No domain graphic available
Description	Transcription cofactor vestigial-like protein 4 (Vgl-4).

LBXCO_HUMAN
NC score	0.021010 (rank : 41)	θ value	1.81305 (rank : 44)
Query Neighborhood Hits	66	Target Neighborhood Hits	167	Shared Neighborhood Hits	5
SwissProt Accessions	P84550	Gene names	LBXCOR1
Domain Architecture	No domain graphic available
Description	Ladybird homeobox corepressor 1.

TNT_HUMAN
NC score	0.019024 (rank : 42)	θ value	3.0926 (rank : 45)
Query Neighborhood Hits	66	Target Neighborhood Hits	14	Shared Neighborhood Hits	2
SwissProt Accessions	Q7Z2V1, Q8NEF0	Gene names
Domain Architecture	No domain graphic available
Description	Protein TNT.

CE025_HUMAN
NC score	0.017240 (rank : 43)	θ value	8.99809 (rank : 61)
Query Neighborhood Hits	66	Target Neighborhood Hits	114	Shared Neighborhood Hits	7
SwissProt Accessions	Q8NDZ2, Q6NXN8, Q6ZTU4, Q8IZ15	Gene names	C5orf25
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C5orf25.

K1794_HUMAN
NC score	0.017112 (rank : 44)	θ value	5.27518 (rank : 55)
Query Neighborhood Hits	66	Target Neighborhood Hits	29	Shared Neighborhood Hits	4
SwissProt Accessions	Q9NVI1, Q96JN1, Q96ST0, Q9BT96	Gene names	KIAA1794
Domain Architecture	No domain graphic available
Description	Protein KIAA1794.

CF059_HUMAN
NC score	0.014519 (rank : 45)	θ value	5.27518 (rank : 51)
Query Neighborhood Hits	66	Target Neighborhood Hits	2	Shared Neighborhood Hits	2
SwissProt Accessions	Q9H0P7, Q2M1M7, Q5TEF2, Q9H5S5	Gene names	C6orf59
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C6orf59.

NEST_HUMAN
NC score	0.013983 (rank : 46)	θ value	0.00102713 (rank : 39)
Query Neighborhood Hits	66	Target Neighborhood Hits	1305	Shared Neighborhood Hits	10
SwissProt Accessions	P48681, O00552	Gene names	NES
Domain Architecture
Description	Nestin.

TP53B_HUMAN
NC score	0.011258 (rank : 47)	θ value	6.88961 (rank : 59)
Query Neighborhood Hits	66	Target Neighborhood Hits	413	Shared Neighborhood Hits	7
SwissProt Accessions	Q12888, Q2M1Z7, Q4LE46, Q5FWZ3, Q7Z3U4	Gene names	TP53BP1
Domain Architecture
Description	Tumor suppressor p53-binding protein 1 (p53-binding protein 1) (p53BP1) (53BP1).

FBXL6_MOUSE
NC score	0.009499 (rank : 48)	θ value	5.27518 (rank : 54)
Query Neighborhood Hits	66	Target Neighborhood Hits	55	Shared Neighborhood Hits	3
SwissProt Accessions	Q9QXW0, Q9JJD7	Gene names	Fbxl6, Fbl6
Domain Architecture	No domain graphic available
Description	F-box/LRR-repeat protein 6 (F-box and leucine-rich repeat protein 6) (F-box protein FBL6).

UBP34_HUMAN
NC score	0.008476 (rank : 49)	θ value	3.0926 (rank : 46)
Query Neighborhood Hits	66	Target Neighborhood Hits	210	Shared Neighborhood Hits	4
SwissProt Accessions	Q70CQ2, O60316, O94834, Q3B777, Q6P6C9, Q7L8P6, Q8N3T9, Q8TBW2, Q9UGA1	Gene names	USP34, KIAA0570, KIAA0729
Domain Architecture	No domain graphic available
Description	Ubiquitin carboxyl-terminal hydrolase 34 (EC 3.1.2.15) (Ubiquitin thioesterase 34) (Ubiquitin-specific-processing protease 34) (Deubiquitinating enzyme 34).

SRRM2_MOUSE
NC score	0.007634 (rank : 50)	θ value	4.03905 (rank : 49)
Query Neighborhood Hits	66	Target Neighborhood Hits	1470	Shared Neighborhood Hits	13
SwissProt Accessions	Q8BTI8, Q3TBY5, Q569P9, Q80U37, Q8K383	Gene names	Srrm2, Kiaa0324
Domain Architecture	No domain graphic available
Description	Serine/arginine repetitive matrix protein 2.

JPH2_HUMAN
NC score	0.006472 (rank : 51)	θ value	1.81305 (rank : 43)
Query Neighborhood Hits	66	Target Neighborhood Hits	639	Shared Neighborhood Hits	6
SwissProt Accessions	Q9BR39, O95913, Q5JY74, Q9UJN4	Gene names	JPH2, JP2
Domain Architecture
Description	Junctophilin-2 (Junctophilin type 2) (JP-2).

T22D4_HUMAN
NC score	0.005592 (rank : 52)	θ value	4.03905 (rank : 50)
Query Neighborhood Hits	66	Target Neighborhood Hits	403	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y3Q8	Gene names	TSC22D4, TILZ2
Domain Architecture
Description	TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1).

CTND1_MOUSE
NC score	0.005162 (rank : 53)	θ value	5.27518 (rank : 52)
Query Neighborhood Hits	66	Target Neighborhood Hits	69	Shared Neighborhood Hits	3
SwissProt Accessions	P30999	Gene names	Ctnnd1, Catns
Domain Architecture
Description	Catenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Src substrate) (CAS) (p120(cas)).

LIX1L_HUMAN
NC score	0.004635 (rank : 54)	θ value	8.99809 (rank : 66)
Query Neighborhood Hits	66	Target Neighborhood Hits	31	Shared Neighborhood Hits	2
SwissProt Accessions	Q8IVB5, Q6AI36	Gene names	LIX1L
Domain Architecture	No domain graphic available
Description	LIX1-like protein.

CTND1_HUMAN
NC score	0.004436 (rank : 55)	θ value	8.99809 (rank : 62)
Query Neighborhood Hits	66	Target Neighborhood Hits	67	Shared Neighborhood Hits	3
SwissProt Accessions	O60716, O15088, O60713, O60714, O60715, O60935, Q6RBX8, Q9UP71, Q9UP72, Q9UP73	Gene names	CTNND1, KIAA0384
Domain Architecture
Description	Catenin delta-1 (p120 catenin) (p120(ctn)) (Cadherin-associated Src substrate) (CAS) (p120(cas)).

FARP1_HUMAN
NC score	0.004105 (rank : 56)	θ value	5.27518 (rank : 53)
Query Neighborhood Hits	66	Target Neighborhood Hits	241	Shared Neighborhood Hits	3
SwissProt Accessions	Q9Y4F1, Q6IQ29	Gene names	FARP1, CDEP
Domain Architecture	No domain graphic available
Description	FERM, RhoGEF and pleckstrin domain-containing protein 1 (Chondrocyte- derived ezrin-like protein).

MITF_MOUSE
NC score	0.004082 (rank : 57)	θ value	6.88961 (rank : 58)
Query Neighborhood Hits	66	Target Neighborhood Hits	115	Shared Neighborhood Hits	2
SwissProt Accessions	Q08874, O08885, O88203, Q08843, Q60781, Q60782, Q9JIJ0, Q9JIJ1, Q9JIJ2, Q9JIJ3, Q9JIJ4, Q9JIJ5, Q9JIJ6, Q9JKX9	Gene names	Mitf, Bw, Mi, Vit
Domain Architecture
Description	Microphthalmia-associated transcription factor.

PRDM2_HUMAN
NC score	0.003883 (rank : 58)	θ value	0.813845 (rank : 40)
Query Neighborhood Hits	66	Target Neighborhood Hits	1135	Shared Neighborhood Hits	12
SwissProt Accessions	Q13029, Q13149, Q14550, Q5VUL9	Gene names	PRDM2, RIZ
Domain Architecture
Description	PR domain zinc finger protein 2 (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc-finger protein) (Zinc finger protein RIZ) (MTE-binding protein) (MTB-ZF) (GATA-3-binding protein G3B).

NCOA6_HUMAN
NC score	0.002621 (rank : 59)	θ value	5.27518 (rank : 56)
Query Neighborhood Hits	66	Target Neighborhood Hits	1202	Shared Neighborhood Hits	9
SwissProt Accessions	Q14686, Q9NTZ9, Q9UH74, Q9UK86	Gene names	NCOA6, AIB3, KIAA0181, RAP250, TRBP
Domain Architecture	No domain graphic available
Description	Nuclear receptor coactivator 6 (Amplified in breast cancer protein 3) (Cancer-amplified transcriptional coactivator ASC-2) (Activating signal cointegrator 2) (ASC-2) (Peroxisome proliferator-activated receptor-interacting protein) (PPAR-interacting protein) (PRIP) (Nuclear receptor-activating protein, 250 kDa) (Nuclear receptor coactivator RAP250) (NRC RAP250) (Thyroid hormone receptor-binding protein).

ACCN4_HUMAN
NC score	0.002510 (rank : 60)	θ value	8.99809 (rank : 60)
Query Neighborhood Hits	66	Target Neighborhood Hits	26	Shared Neighborhood Hits	2
SwissProt Accessions	Q96FT7, Q53SB7, Q6GMS1, Q6PIN9, Q9NQA4	Gene names	ACCN4, ASIC4
Domain Architecture	No domain graphic available
Description	Amiloride-sensitive cation channel 4 (Amiloride-sensitive cation channel 4, pituitary) (Acid-sensing ion channel 4).

ABCA2_HUMAN
NC score	0.002101 (rank : 61)	θ value	4.03905 (rank : 48)
Query Neighborhood Hits	66	Target Neighborhood Hits	143	Shared Neighborhood Hits	2
SwissProt Accessions	Q9BZC7	Gene names	ABCA2, ABC2
Domain Architecture
Description	ATP-binding cassette sub-family A member 2 (ATP-binding cassette transporter 2) (ATP-binding cassette 2).

ZO2_MOUSE
NC score	0.002094 (rank : 62)	θ value	5.27518 (rank : 57)
Query Neighborhood Hits	66	Target Neighborhood Hits	296	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z0U1, Q8K210	Gene names	Tjp2, Zo2
Domain Architecture
Description	Tight junction protein ZO-2 (Zonula occludens 2 protein) (Zona occludens 2 protein) (Tight junction protein 2).

KIF4A_MOUSE
NC score	-0.000984 (rank : 63)	θ value	8.99809 (rank : 65)
Query Neighborhood Hits	66	Target Neighborhood Hits	1033	Shared Neighborhood Hits	7
SwissProt Accessions	P33174	Gene names	Kif4a, Kif4, Kns4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

CUTL1_MOUSE
NC score	-0.001027 (rank : 64)	θ value	8.99809 (rank : 63)
Query Neighborhood Hits	66	Target Neighborhood Hits	1620	Shared Neighborhood Hits	11
SwissProt Accessions	P53564, O08994, P70301, Q571L6, Q91ZD2	Gene names	Cutl1, Cux, Cux1, Kiaa4047
Domain Architecture	No domain graphic available
Description	Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (Homeobox protein Cux).

KIF4A_HUMAN
NC score	-0.001691 (rank : 65)	θ value	8.99809 (rank : 64)
Query Neighborhood Hits	66	Target Neighborhood Hits	1159	Shared Neighborhood Hits	6
SwissProt Accessions	O95239, Q86TN3, Q86XX7, Q9NNY6, Q9NY24, Q9UMW3	Gene names	KIF4A, KIF4
Domain Architecture
Description	Chromosome-associated kinesin KIF4A (Chromokinesin).

ZIC2_MOUSE
NC score	-0.003946 (rank : 66)	θ value	3.0926 (rank : 47)
Query Neighborhood Hits	66	Target Neighborhood Hits	727	Shared Neighborhood Hits	3
SwissProt Accessions	Q62520	Gene names	Zic2
Domain Architecture	No domain graphic available
Description	Zinc finger protein ZIC 2 (Zinc finger protein of the cerebellum 2).