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Network neighborhood for query Sequence : SAMH1_HUMAN

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SAMH1_HUMAN
SwissProt Accessions	Q9Y3Z3, Q5JXG8, Q9H004, Q9H005, Q9H3U9	Gene names	SAMHD1, MOP5
Domain Architecture
Description	SAM domain and HD domain-containing protein 1 (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

SAMH1_HUMAN
θ value	0 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	14	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y3Z3, Q5JXG8, Q9H004, Q9H005, Q9H3U9	Gene names	SAMHD1, MOP5
Domain Architecture
Description	SAM domain and HD domain-containing protein 1 (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5).

SAMH1_MOUSE
θ value	0 (rank : 2)	NC score	0.982823 (rank : 2)
Query Neighborhood Hits	14	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	Q60710, Q91VK8	Gene names	Samhd1, Mg11
Domain Architecture
Description	SAM domain and HD domain-containing protein 1 (Interferon-gamma- inducible protein Mg11).

USH2A_HUMAN
θ value	0.0961366 (rank : 3)	NC score	0.032121 (rank : 6)
Query Neighborhood Hits	14	Target Neighborhood Hits	600	Shared Neighborhood Hits	3
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

CNKR2_HUMAN
θ value	1.06291 (rank : 4)	NC score	0.063100 (rank : 4)
Query Neighborhood Hits	14	Target Neighborhood Hits	197	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_MOUSE
θ value	1.06291 (rank : 5)	NC score	0.063109 (rank : 3)
Query Neighborhood Hits	14	Target Neighborhood Hits	197	Shared Neighborhood Hits	5
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CYTSA_HUMAN
θ value	1.06291 (rank : 6)	NC score	0.018515 (rank : 9)
Query Neighborhood Hits	14	Target Neighborhood Hits	1138	Shared Neighborhood Hits	3
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

JPH1_MOUSE
θ value	1.06291 (rank : 7)	NC score	0.024277 (rank : 8)
Query Neighborhood Hits	14	Target Neighborhood Hits	120	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ET80, Q9EQZ3	Gene names	Jph1, Jp1
Domain Architecture
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

CYTSA_MOUSE
θ value	2.36792 (rank : 8)	NC score	0.016837 (rank : 11)
Query Neighborhood Hits	14	Target Neighborhood Hits	1104	Shared Neighborhood Hits	3
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

SAMD8_MOUSE
θ value	2.36792 (rank : 9)	NC score	0.034110 (rank : 5)
Query Neighborhood Hits	14	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q9DA37	Gene names	Samd8
Domain Architecture
Description	Sphingomyelin synthase-related protein 1 (Sterile alpha motif domain- containing 8).

SAMD8_HUMAN
θ value	4.03905 (rank : 10)	NC score	0.031488 (rank : 7)
Query Neighborhood Hits	14	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q96LT4	Gene names	SAMD8
Domain Architecture
Description	Sphingomyelin synthase-related protein 1 (Sterile alpha motif domain- containing 8).

FAS_HUMAN
θ value	5.27518 (rank : 11)	NC score	0.016982 (rank : 10)
Query Neighborhood Hits	14	Target Neighborhood Hits	66	Shared Neighborhood Hits	2
SwissProt Accessions	P49327, Q13479, Q16702, Q6P4U5, Q6SS02, Q969R1, Q96C68, Q96IT0	Gene names	FASN, FAS
Domain Architecture
Description	Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S- acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S- malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.10); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)].

MLTK_HUMAN
θ value	8.99809 (rank : 12)	NC score	0.002683 (rank : 14)
Query Neighborhood Hits	14	Target Neighborhood Hits	911	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).

NANO3_HUMAN
θ value	8.99809 (rank : 13)	NC score	0.016033 (rank : 12)
Query Neighborhood Hits	14	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	P60323	Gene names	NANOS3, NOS3
Domain Architecture	No domain graphic available
Description	Nanos homolog 3.

PDE9A_MOUSE
θ value	8.99809 (rank : 14)	NC score	0.006787 (rank : 13)
Query Neighborhood Hits	14	Target Neighborhood Hits	72	Shared Neighborhood Hits	2
SwissProt Accessions	O70628	Gene names	Pde9a, Pde8b
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

Hits sorted by NC score

SAMH1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 1)
Query Neighborhood Hits	14	Target Neighborhood Hits	14	Shared Neighborhood Hits	14
SwissProt Accessions	Q9Y3Z3, Q5JXG8, Q9H004, Q9H005, Q9H3U9	Gene names	SAMHD1, MOP5
Domain Architecture
Description	SAM domain and HD domain-containing protein 1 (Dendritic cell-derived IFNG-induced protein) (DCIP) (Monocyte protein 5) (MOP-5).

SAMH1_MOUSE
NC score	0.982823 (rank : 2)	θ value	0 (rank : 2)
Query Neighborhood Hits	14	Target Neighborhood Hits	19	Shared Neighborhood Hits	6
SwissProt Accessions	Q60710, Q91VK8	Gene names	Samhd1, Mg11
Domain Architecture
Description	SAM domain and HD domain-containing protein 1 (Interferon-gamma- inducible protein Mg11).

CNKR2_MOUSE
NC score	0.063109 (rank : 3)	θ value	1.06291 (rank : 5)
Query Neighborhood Hits	14	Target Neighborhood Hits	197	Shared Neighborhood Hits	5
SwissProt Accessions	Q80YA9, Q80TP2	Gene names	Cnksr2, Kiaa0902
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

CNKR2_HUMAN
NC score	0.063100 (rank : 4)	θ value	1.06291 (rank : 4)
Query Neighborhood Hits	14	Target Neighborhood Hits	197	Shared Neighborhood Hits	5
SwissProt Accessions	Q8WXI2, O94976, Q8WXI1	Gene names	CNKSR2, CNK2, KIAA0902, KSR2
Domain Architecture	No domain graphic available
Description	Connector enhancer of kinase suppressor of ras 2 (Connector enhancer of KSR2) (CNK2).

SAMD8_MOUSE
NC score	0.034110 (rank : 5)	θ value	2.36792 (rank : 9)
Query Neighborhood Hits	14	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q9DA37	Gene names	Samd8
Domain Architecture
Description	Sphingomyelin synthase-related protein 1 (Sterile alpha motif domain- containing 8).

USH2A_HUMAN
NC score	0.032121 (rank : 6)	θ value	0.0961366 (rank : 3)
Query Neighborhood Hits	14	Target Neighborhood Hits	600	Shared Neighborhood Hits	3
SwissProt Accessions	O75445, Q5VVM9, Q6S362, Q9NS27	Gene names	USH2A
Domain Architecture	No domain graphic available
Description	Usherin precursor (Usher syndrome type-2A protein) (Usher syndrome type IIa protein).

SAMD8_HUMAN
NC score	0.031488 (rank : 7)	θ value	4.03905 (rank : 10)
Query Neighborhood Hits	14	Target Neighborhood Hits	22	Shared Neighborhood Hits	3
SwissProt Accessions	Q96LT4	Gene names	SAMD8
Domain Architecture
Description	Sphingomyelin synthase-related protein 1 (Sterile alpha motif domain- containing 8).

JPH1_MOUSE
NC score	0.024277 (rank : 8)	θ value	1.06291 (rank : 7)
Query Neighborhood Hits	14	Target Neighborhood Hits	120	Shared Neighborhood Hits	2
SwissProt Accessions	Q9ET80, Q9EQZ3	Gene names	Jph1, Jp1
Domain Architecture
Description	Junctophilin-1 (Junctophilin type 1) (JP-1).

CYTSA_HUMAN
NC score	0.018515 (rank : 9)	θ value	1.06291 (rank : 6)
Query Neighborhood Hits	14	Target Neighborhood Hits	1138	Shared Neighborhood Hits	3
SwissProt Accessions	Q69YQ0, O15081	Gene names	CYTSA, KIAA0376
Domain Architecture	No domain graphic available
Description	Cytospin-A (NY-REN-22 antigen).

FAS_HUMAN
NC score	0.016982 (rank : 10)	θ value	5.27518 (rank : 11)
Query Neighborhood Hits	14	Target Neighborhood Hits	66	Shared Neighborhood Hits	2
SwissProt Accessions	P49327, Q13479, Q16702, Q6P4U5, Q6SS02, Q969R1, Q96C68, Q96IT0	Gene names	FASN, FAS
Domain Architecture
Description	Fatty acid synthase (EC 2.3.1.85) [Includes: [Acyl-carrier-protein] S- acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] S- malonyltransferase (EC 2.3.1.39); 3-oxoacyl-[acyl-carrier-protein] synthase (EC 2.3.1.41); 3-oxoacyl-[acyl-carrier-protein] reductase (EC 1.1.1.100); 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.61); Enoyl-[acyl-carrier-protein] reductase (EC 1.3.1.10); Oleoyl-[acyl-carrier-protein] hydrolase (EC 3.1.2.14)].

CYTSA_MOUSE
NC score	0.016837 (rank : 11)	θ value	2.36792 (rank : 8)
Query Neighborhood Hits	14	Target Neighborhood Hits	1104	Shared Neighborhood Hits	3
SwissProt Accessions	Q2KN98, Q8CHF9	Gene names	Cytsa, Kiaa0376
Domain Architecture	No domain graphic available
Description	Cytospin-A.

NANO3_HUMAN
NC score	0.016033 (rank : 12)	θ value	8.99809 (rank : 13)
Query Neighborhood Hits	14	Target Neighborhood Hits	27	Shared Neighborhood Hits	2
SwissProt Accessions	P60323	Gene names	NANOS3, NOS3
Domain Architecture	No domain graphic available
Description	Nanos homolog 3.

PDE9A_MOUSE
NC score	0.006787 (rank : 13)	θ value	8.99809 (rank : 14)
Query Neighborhood Hits	14	Target Neighborhood Hits	72	Shared Neighborhood Hits	2
SwissProt Accessions	O70628	Gene names	Pde9a, Pde8b
Domain Architecture
Description	High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35).

MLTK_HUMAN
NC score	0.002683 (rank : 14)	θ value	8.99809 (rank : 12)
Query Neighborhood Hits	14	Target Neighborhood Hits	911	Shared Neighborhood Hits	5
SwissProt Accessions	Q9NYL2, Q53SX1, Q580W8, Q59GY5, Q86YW8, Q9HCC4, Q9HCC5, Q9HDD2, Q9NYE9	Gene names	MLTK, ZAK
Domain Architecture	No domain graphic available
Description	Mitogen-activated protein kinase kinase kinase MLT (EC 2.7.11.25) (MLK-like mitogen-activated protein triple kinase) (Leucine zipper- and sterile alpha motif-containing kinase) (Sterile alpha motif- and leucine zipper-containing kinase AZK) (Mixed lineage kinase-related kinase) (MLK-related kinase) (MRK) (Cervical cancer suppressor gene 4 protein).