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Network neighborhood for query Sequence : DSCR8_HUMAN

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DSCR8_HUMAN
SwissProt Accessions	Q96T75, Q8N3X0, Q8NDY5, Q96B46	Gene names	DSCR8, C21orf65, MTAG2
Domain Architecture	No domain graphic available
Description	Down syndrome critical region protein 8 (Malignant melanoma-associated protein 1) (MMA-1) (MTAG2 protein).
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

DSCR8_HUMAN
θ value	3.84914e-51 (rank : 1)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	7	Target Neighborhood Hits	7	Shared Neighborhood Hits	7
SwissProt Accessions	Q96T75, Q8N3X0, Q8NDY5, Q96B46	Gene names	DSCR8, C21orf65, MTAG2
Domain Architecture	No domain graphic available
Description	Down syndrome critical region protein 8 (Malignant melanoma-associated protein 1) (MMA-1) (MTAG2 protein).

M4K1_HUMAN
θ value	0.21417 (rank : 2)	NC score	0.022205 (rank : 5)
Query Neighborhood Hits	7	Target Neighborhood Hits	884	Shared Neighborhood Hits	7
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

MTO1_HUMAN
θ value	2.36792 (rank : 3)	NC score	0.072759 (rank : 2)
Query Neighborhood Hits	7	Target Neighborhood Hits	30	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y2Z2, Q5SWL2, Q5SWL3, Q5SWL4, Q8NDN7, Q8WZ57, Q96FE6, Q9BS06	Gene names	MTO1
Domain Architecture
Description	Protein MTO1 homolog, mitochondrial precursor.

NPCL1_HUMAN
θ value	2.36792 (rank : 4)	NC score	0.050706 (rank : 3)
Query Neighborhood Hits	7	Target Neighborhood Hits	25	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UHC9, Q6R3Q4, Q9UHC8	Gene names	NPC1L1
Domain Architecture	No domain graphic available
Description	Niemann-Pick C1-like protein 1 precursor.

CI039_HUMAN
θ value	3.0926 (rank : 5)	NC score	0.025057 (rank : 4)
Query Neighborhood Hits	7	Target Neighborhood Hits	1171	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

ITCH_HUMAN
θ value	8.99809 (rank : 6)	NC score	0.020074 (rank : 6)
Query Neighborhood Hits	7	Target Neighborhood Hits	162	Shared Neighborhood Hits	7
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

NEK4_HUMAN
θ value	8.99809 (rank : 7)	NC score	0.009364 (rank : 7)
Query Neighborhood Hits	7	Target Neighborhood Hits	883	Shared Neighborhood Hits	7
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

Hits sorted by NC score

DSCR8_HUMAN
NC score	0.999962 (rank : 1)	θ value	3.84914e-51 (rank : 1)
Query Neighborhood Hits	7	Target Neighborhood Hits	7	Shared Neighborhood Hits	7
SwissProt Accessions	Q96T75, Q8N3X0, Q8NDY5, Q96B46	Gene names	DSCR8, C21orf65, MTAG2
Domain Architecture	No domain graphic available
Description	Down syndrome critical region protein 8 (Malignant melanoma-associated protein 1) (MMA-1) (MTAG2 protein).

MTO1_HUMAN
NC score	0.072759 (rank : 2)	θ value	2.36792 (rank : 3)
Query Neighborhood Hits	7	Target Neighborhood Hits	30	Shared Neighborhood Hits	6
SwissProt Accessions	Q9Y2Z2, Q5SWL2, Q5SWL3, Q5SWL4, Q8NDN7, Q8WZ57, Q96FE6, Q9BS06	Gene names	MTO1
Domain Architecture
Description	Protein MTO1 homolog, mitochondrial precursor.

NPCL1_HUMAN
NC score	0.050706 (rank : 3)	θ value	2.36792 (rank : 4)
Query Neighborhood Hits	7	Target Neighborhood Hits	25	Shared Neighborhood Hits	6
SwissProt Accessions	Q9UHC9, Q6R3Q4, Q9UHC8	Gene names	NPC1L1
Domain Architecture	No domain graphic available
Description	Niemann-Pick C1-like protein 1 precursor.

CI039_HUMAN
NC score	0.025057 (rank : 4)	θ value	3.0926 (rank : 5)
Query Neighborhood Hits	7	Target Neighborhood Hits	1171	Shared Neighborhood Hits	7
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

M4K1_HUMAN
NC score	0.022205 (rank : 5)	θ value	0.21417 (rank : 2)
Query Neighborhood Hits	7	Target Neighborhood Hits	884	Shared Neighborhood Hits	7
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

ITCH_HUMAN
NC score	0.020074 (rank : 6)	θ value	8.99809 (rank : 6)
Query Neighborhood Hits	7	Target Neighborhood Hits	162	Shared Neighborhood Hits	7
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

NEK4_HUMAN
NC score	0.009364 (rank : 7)	θ value	8.99809 (rank : 7)
Query Neighborhood Hits	7	Target Neighborhood Hits	883	Shared Neighborhood Hits	7
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).