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Network neighborhood for query Sequence : NPCL1_HUMAN

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NPCL1_HUMAN
SwissProt Accessions	Q9UHC9, Q6R3Q4, Q9UHC8	Gene names	NPC1L1
Domain Architecture	No domain graphic available
Description	Niemann-Pick C1-like protein 1 precursor.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NPC1_HUMAN
θ value	0 (rank : 1)	NC score	0.966225 (rank : 3)
Query Neighborhood Hits	25	Target Neighborhood Hits	19	Shared Neighborhood Hits	9
SwissProt Accessions	O15118, Q9P130	Gene names	NPC1
Domain Architecture
Description	Niemann-Pick C1 protein precursor.

NPC1_MOUSE
θ value	0 (rank : 2)	NC score	0.966119 (rank : 4)
Query Neighborhood Hits	25	Target Neighborhood Hits	18	Shared Neighborhood Hits	9
SwissProt Accessions	O35604, O35605	Gene names	Npc1
Domain Architecture
Description	Niemann-Pick C1 protein precursor.

NPCL1_HUMAN
θ value	0 (rank : 3)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	25	Target Neighborhood Hits	25	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UHC9, Q6R3Q4, Q9UHC8	Gene names	NPC1L1
Domain Architecture	No domain graphic available
Description	Niemann-Pick C1-like protein 1 precursor.

NPCL1_MOUSE
θ value	0 (rank : 4)	NC score	0.996665 (rank : 2)
Query Neighborhood Hits	25	Target Neighborhood Hits	21	Shared Neighborhood Hits	11
SwissProt Accessions	Q6T3U4, Q5SVX1	Gene names	Npc1l1
Domain Architecture	No domain graphic available
Description	Niemann-Pick C1-like protein 1 precursor.

PTC2_MOUSE
θ value	1.13037e-18 (rank : 5)	NC score	0.567593 (rank : 5)
Query Neighborhood Hits	25	Target Neighborhood Hits	20	Shared Neighborhood Hits	9
SwissProt Accessions	O35595, Q546T0	Gene names	Ptch2
Domain Architecture
Description	Protein patched homolog 2 (PTC2).

PTC1_HUMAN
θ value	1.47631e-18 (rank : 6)	NC score	0.565937 (rank : 6)
Query Neighborhood Hits	25	Target Neighborhood Hits	37	Shared Neighborhood Hits	9
SwissProt Accessions	Q13635, Q13463, Q5VZC0	Gene names	PTCH1, PTCH
Domain Architecture
Description	Protein patched homolog 1 (PTC1) (PTC).

PTC1_MOUSE
θ value	1.47631e-18 (rank : 7)	NC score	0.564890 (rank : 7)
Query Neighborhood Hits	25	Target Neighborhood Hits	43	Shared Neighborhood Hits	9
SwissProt Accessions	Q61115	Gene names	Ptch1, Ptch
Domain Architecture
Description	Protein patched homolog 1 (PTC1) (PTC).

PTC2_HUMAN
θ value	4.29542e-18 (rank : 8)	NC score	0.562421 (rank : 8)
Query Neighborhood Hits	25	Target Neighborhood Hits	63	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6C5, O95341, O95856, Q5QP87, Q6UX14	Gene names	PTCH2
Domain Architecture
Description	Protein patched homolog 2 (PTC2).

SCAP_HUMAN
θ value	1.99992e-07 (rank : 9)	NC score	0.291826 (rank : 9)
Query Neighborhood Hits	25	Target Neighborhood Hits	368	Shared Neighborhood Hits	9
SwissProt Accessions	Q12770, Q8N2E0, Q8WUA1	Gene names	SCAP, KIAA0199
Domain Architecture
Description	Sterol regulatory element-binding protein cleavage-activating protein (SREBP cleavage-activating protein) (SCAP).

M4K1_HUMAN
θ value	0.365318 (rank : 10)	NC score	0.005620 (rank : 22)
Query Neighborhood Hits	25	Target Neighborhood Hits	884	Shared Neighborhood Hits	9
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

ASCC1_HUMAN
θ value	0.62314 (rank : 11)	NC score	0.044975 (rank : 13)
Query Neighborhood Hits	25	Target Neighborhood Hits	24	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N9N2, Q96EI8, Q9Y307	Gene names	ASCC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 1 (ASC-1 complex subunit p50) (Trip4 complex subunit p50).

CD008_HUMAN
θ value	1.06291 (rank : 12)	NC score	0.038923 (rank : 14)
Query Neighborhood Hits	25	Target Neighborhood Hits	330	Shared Neighborhood Hits	9
SwissProt Accessions	P78312, O43607, P78311, P78313, Q9UEG8	Gene names	C4orf8
Domain Architecture	No domain graphic available
Description	Protein C4orf8 (Protein IT14).

NEK4_HUMAN
θ value	1.06291 (rank : 13)	NC score	0.003863 (rank : 24)
Query Neighborhood Hits	25	Target Neighborhood Hits	883	Shared Neighborhood Hits	9
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

CO2_HUMAN
θ value	1.38821 (rank : 14)	NC score	0.010071 (rank : 16)
Query Neighborhood Hits	25	Target Neighborhood Hits	258	Shared Neighborhood Hits	2
SwissProt Accessions	P06681, O19694, Q13904	Gene names	C2
Domain Architecture
Description	Complement C2 precursor (EC 3.4.21.43) (C3/C5 convertase) [Contains: Complement C2b fragment; Complement C2a fragment].

DSCR8_HUMAN
θ value	2.36792 (rank : 15)	NC score	0.050706 (rank : 12)
Query Neighborhood Hits	25	Target Neighborhood Hits	7	Shared Neighborhood Hits	6
SwissProt Accessions	Q96T75, Q8N3X0, Q8NDY5, Q96B46	Gene names	DSCR8, C21orf65, MTAG2
Domain Architecture	No domain graphic available
Description	Down syndrome critical region protein 8 (Malignant melanoma-associated protein 1) (MMA-1) (MTAG2 protein).

MDR3_MOUSE
θ value	2.36792 (rank : 16)	NC score	0.009913 (rank : 17)
Query Neighborhood Hits	25	Target Neighborhood Hits	106	Shared Neighborhood Hits	3
SwissProt Accessions	P21447	Gene names	Abcb1a, Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3
Domain Architecture
Description	Multidrug resistance protein 3 (EC 3.6.3.44) (ATP-binding cassette sub-family B member 1A) (P-glycoprotein 3) (MDR1A).

CN130_MOUSE
θ value	3.0926 (rank : 17)	NC score	0.020356 (rank : 15)
Query Neighborhood Hits	25	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BU04, Q80UT9	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf130 homolog.

MDR1_MOUSE
θ value	3.0926 (rank : 18)	NC score	0.009398 (rank : 18)
Query Neighborhood Hits	25	Target Neighborhood Hits	105	Shared Neighborhood Hits	3
SwissProt Accessions	P06795	Gene names	Abcb1, Abcb1b, Mdr1, Mdr1b, Pgy1, Pgy1-1
Domain Architecture
Description	Multidrug resistance protein 1 (EC 3.6.3.44) (ATP-binding cassette sub-family B member 1) (P-glycoprotein 1) (CD243 antigen).

CCD46_MOUSE
θ value	4.03905 (rank : 19)	NC score	0.002324 (rank : 25)
Query Neighborhood Hits	25	Target Neighborhood Hits	1405	Shared Neighborhood Hits	5
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

CI039_HUMAN
θ value	6.88961 (rank : 20)	NC score	0.004610 (rank : 23)
Query Neighborhood Hits	25	Target Neighborhood Hits	1171	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

EMR1_MOUSE
θ value	6.88961 (rank : 21)	NC score	0.002069 (rank : 26)
Query Neighborhood Hits	25	Target Neighborhood Hits	349	Shared Neighborhood Hits	2
SwissProt Accessions	Q61549	Gene names	Emr1, Gpf480
Domain Architecture
Description	EGF-like module-containing mucin-like hormone receptor-like 1 precursor (Cell surface glycoprotein EMR1) (EMR1 hormone receptor) (Cell surface glycoprotein F4/80).

MYO9B_HUMAN
θ value	6.88961 (rank : 22)	NC score	0.006453 (rank : 21)
Query Neighborhood Hits	25	Target Neighborhood Hits	641	Shared Neighborhood Hits	7
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

MYO9B_MOUSE
θ value	6.88961 (rank : 23)	NC score	0.006626 (rank : 20)
Query Neighborhood Hits	25	Target Neighborhood Hits	311	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

ITCH_HUMAN
θ value	8.99809 (rank : 24)	NC score	0.007136 (rank : 19)
Query Neighborhood Hits	25	Target Neighborhood Hits	162	Shared Neighborhood Hits	8
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

M3K1_MOUSE
θ value	8.99809 (rank : 25)	NC score	0.000925 (rank : 27)
Query Neighborhood Hits	25	Target Neighborhood Hits	952	Shared Neighborhood Hits	5
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).

HMDH_HUMAN
θ value	θ > 10 (rank : 26)	NC score	0.091641 (rank : 10)
Query Neighborhood Hits	25	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P04035, Q8N190	Gene names	HMGCR
Domain Architecture
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase).

HMDH_MOUSE
θ value	θ > 10 (rank : 27)	NC score	0.090996 (rank : 11)
Query Neighborhood Hits	25	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q01237, Q5U4I2	Gene names	Hmgcr
Domain Architecture	No domain graphic available
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase).

Hits sorted by NC score

NPCL1_HUMAN
NC score	0.999962 (rank : 1)	θ value	0 (rank : 3)
Query Neighborhood Hits	25	Target Neighborhood Hits	25	Shared Neighborhood Hits	25
SwissProt Accessions	Q9UHC9, Q6R3Q4, Q9UHC8	Gene names	NPC1L1
Domain Architecture	No domain graphic available
Description	Niemann-Pick C1-like protein 1 precursor.

NPCL1_MOUSE
NC score	0.996665 (rank : 2)	θ value	0 (rank : 4)
Query Neighborhood Hits	25	Target Neighborhood Hits	21	Shared Neighborhood Hits	11
SwissProt Accessions	Q6T3U4, Q5SVX1	Gene names	Npc1l1
Domain Architecture	No domain graphic available
Description	Niemann-Pick C1-like protein 1 precursor.

NPC1_HUMAN
NC score	0.966225 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	25	Target Neighborhood Hits	19	Shared Neighborhood Hits	9
SwissProt Accessions	O15118, Q9P130	Gene names	NPC1
Domain Architecture
Description	Niemann-Pick C1 protein precursor.

NPC1_MOUSE
NC score	0.966119 (rank : 4)	θ value	0 (rank : 2)
Query Neighborhood Hits	25	Target Neighborhood Hits	18	Shared Neighborhood Hits	9
SwissProt Accessions	O35604, O35605	Gene names	Npc1
Domain Architecture
Description	Niemann-Pick C1 protein precursor.

PTC2_MOUSE
NC score	0.567593 (rank : 5)	θ value	1.13037e-18 (rank : 5)
Query Neighborhood Hits	25	Target Neighborhood Hits	20	Shared Neighborhood Hits	9
SwissProt Accessions	O35595, Q546T0	Gene names	Ptch2
Domain Architecture
Description	Protein patched homolog 2 (PTC2).

PTC1_HUMAN
NC score	0.565937 (rank : 6)	θ value	1.47631e-18 (rank : 6)
Query Neighborhood Hits	25	Target Neighborhood Hits	37	Shared Neighborhood Hits	9
SwissProt Accessions	Q13635, Q13463, Q5VZC0	Gene names	PTCH1, PTCH
Domain Architecture
Description	Protein patched homolog 1 (PTC1) (PTC).

PTC1_MOUSE
NC score	0.564890 (rank : 7)	θ value	1.47631e-18 (rank : 7)
Query Neighborhood Hits	25	Target Neighborhood Hits	43	Shared Neighborhood Hits	9
SwissProt Accessions	Q61115	Gene names	Ptch1, Ptch
Domain Architecture
Description	Protein patched homolog 1 (PTC1) (PTC).

PTC2_HUMAN
NC score	0.562421 (rank : 8)	θ value	4.29542e-18 (rank : 8)
Query Neighborhood Hits	25	Target Neighborhood Hits	63	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6C5, O95341, O95856, Q5QP87, Q6UX14	Gene names	PTCH2
Domain Architecture
Description	Protein patched homolog 2 (PTC2).

SCAP_HUMAN
NC score	0.291826 (rank : 9)	θ value	1.99992e-07 (rank : 9)
Query Neighborhood Hits	25	Target Neighborhood Hits	368	Shared Neighborhood Hits	9
SwissProt Accessions	Q12770, Q8N2E0, Q8WUA1	Gene names	SCAP, KIAA0199
Domain Architecture
Description	Sterol regulatory element-binding protein cleavage-activating protein (SREBP cleavage-activating protein) (SCAP).

HMDH_HUMAN
NC score	0.091641 (rank : 10)	θ value	θ > 10 (rank : 26)
Query Neighborhood Hits	25	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P04035, Q8N190	Gene names	HMGCR
Domain Architecture
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase).

HMDH_MOUSE
NC score	0.090996 (rank : 11)	θ value	θ > 10 (rank : 27)
Query Neighborhood Hits	25	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q01237, Q5U4I2	Gene names	Hmgcr
Domain Architecture	No domain graphic available
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase).

DSCR8_HUMAN
NC score	0.050706 (rank : 12)	θ value	2.36792 (rank : 15)
Query Neighborhood Hits	25	Target Neighborhood Hits	7	Shared Neighborhood Hits	6
SwissProt Accessions	Q96T75, Q8N3X0, Q8NDY5, Q96B46	Gene names	DSCR8, C21orf65, MTAG2
Domain Architecture	No domain graphic available
Description	Down syndrome critical region protein 8 (Malignant melanoma-associated protein 1) (MMA-1) (MTAG2 protein).

ASCC1_HUMAN
NC score	0.044975 (rank : 13)	θ value	0.62314 (rank : 11)
Query Neighborhood Hits	25	Target Neighborhood Hits	24	Shared Neighborhood Hits	7
SwissProt Accessions	Q8N9N2, Q96EI8, Q9Y307	Gene names	ASCC1
Domain Architecture	No domain graphic available
Description	Activating signal cointegrator 1 complex subunit 1 (ASC-1 complex subunit p50) (Trip4 complex subunit p50).

CD008_HUMAN
NC score	0.038923 (rank : 14)	θ value	1.06291 (rank : 12)
Query Neighborhood Hits	25	Target Neighborhood Hits	330	Shared Neighborhood Hits	9
SwissProt Accessions	P78312, O43607, P78311, P78313, Q9UEG8	Gene names	C4orf8
Domain Architecture	No domain graphic available
Description	Protein C4orf8 (Protein IT14).

CN130_MOUSE
NC score	0.020356 (rank : 15)	θ value	3.0926 (rank : 17)
Query Neighborhood Hits	25	Target Neighborhood Hits	39	Shared Neighborhood Hits	2
SwissProt Accessions	Q8BU04, Q80UT9	Gene names
Domain Architecture	No domain graphic available
Description	Uncharacterized protein C14orf130 homolog.

CO2_HUMAN
NC score	0.010071 (rank : 16)	θ value	1.38821 (rank : 14)
Query Neighborhood Hits	25	Target Neighborhood Hits	258	Shared Neighborhood Hits	2
SwissProt Accessions	P06681, O19694, Q13904	Gene names	C2
Domain Architecture
Description	Complement C2 precursor (EC 3.4.21.43) (C3/C5 convertase) [Contains: Complement C2b fragment; Complement C2a fragment].

MDR3_MOUSE
NC score	0.009913 (rank : 17)	θ value	2.36792 (rank : 16)
Query Neighborhood Hits	25	Target Neighborhood Hits	106	Shared Neighborhood Hits	3
SwissProt Accessions	P21447	Gene names	Abcb1a, Abcb4, Mdr1a, Mdr3, Pgy-3, Pgy3
Domain Architecture
Description	Multidrug resistance protein 3 (EC 3.6.3.44) (ATP-binding cassette sub-family B member 1A) (P-glycoprotein 3) (MDR1A).

MDR1_MOUSE
NC score	0.009398 (rank : 18)	θ value	3.0926 (rank : 18)
Query Neighborhood Hits	25	Target Neighborhood Hits	105	Shared Neighborhood Hits	3
SwissProt Accessions	P06795	Gene names	Abcb1, Abcb1b, Mdr1, Mdr1b, Pgy1, Pgy1-1
Domain Architecture
Description	Multidrug resistance protein 1 (EC 3.6.3.44) (ATP-binding cassette sub-family B member 1) (P-glycoprotein 1) (CD243 antigen).

ITCH_HUMAN
NC score	0.007136 (rank : 19)	θ value	8.99809 (rank : 24)
Query Neighborhood Hits	25	Target Neighborhood Hits	162	Shared Neighborhood Hits	8
SwissProt Accessions	Q96J02, O43584, Q5TEL0, Q96F66, Q9BY75, Q9H451, Q9H4U5	Gene names	ITCH
Domain Architecture
Description	Itchy homolog E3 ubiquitin protein ligase (EC 6.3.2.-) (Itch) (Atrophin-1-interacting protein 4) (AIP4) (NFE2-associated polypeptide 1) (NAPP1).

MYO9B_MOUSE
NC score	0.006626 (rank : 20)	θ value	6.88961 (rank : 23)
Query Neighborhood Hits	25	Target Neighborhood Hits	311	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

MYO9B_HUMAN
NC score	0.006453 (rank : 21)	θ value	6.88961 (rank : 22)
Query Neighborhood Hits	25	Target Neighborhood Hits	641	Shared Neighborhood Hits	7
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

M4K1_HUMAN
NC score	0.005620 (rank : 22)	θ value	0.365318 (rank : 10)
Query Neighborhood Hits	25	Target Neighborhood Hits	884	Shared Neighborhood Hits	9
SwissProt Accessions	Q92918	Gene names	MAP4K1, HPK1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1) (Hematopoietic progenitor kinase).

CI039_HUMAN
NC score	0.004610 (rank : 23)	θ value	6.88961 (rank : 20)
Query Neighborhood Hits	25	Target Neighborhood Hits	1171	Shared Neighborhood Hits	9
SwissProt Accessions	Q9NXG0, Q5VYJ0, Q9HAJ5	Gene names	C9orf39
Domain Architecture	No domain graphic available
Description	Protein C9orf39.

NEK4_HUMAN
NC score	0.003863 (rank : 24)	θ value	1.06291 (rank : 13)
Query Neighborhood Hits	25	Target Neighborhood Hits	883	Shared Neighborhood Hits	9
SwissProt Accessions	P51957	Gene names	NEK4, STK2
Domain Architecture
Description	Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2).

CCD46_MOUSE
NC score	0.002324 (rank : 25)	θ value	4.03905 (rank : 19)
Query Neighborhood Hits	25	Target Neighborhood Hits	1405	Shared Neighborhood Hits	5
SwissProt Accessions	Q5PR68, Q80ZN6, Q99JS4, Q9D9T1	Gene names	Ccdc46
Domain Architecture	No domain graphic available
Description	Coiled coil domain-containing protein 46.

EMR1_MOUSE
NC score	0.002069 (rank : 26)	θ value	6.88961 (rank : 21)
Query Neighborhood Hits	25	Target Neighborhood Hits	349	Shared Neighborhood Hits	2
SwissProt Accessions	Q61549	Gene names	Emr1, Gpf480
Domain Architecture
Description	EGF-like module-containing mucin-like hormone receptor-like 1 precursor (Cell surface glycoprotein EMR1) (EMR1 hormone receptor) (Cell surface glycoprotein F4/80).

M3K1_MOUSE
NC score	0.000925 (rank : 27)	θ value	8.99809 (rank : 25)
Query Neighborhood Hits	25	Target Neighborhood Hits	952	Shared Neighborhood Hits	5
SwissProt Accessions	P53349, Q60831, Q9R0U3, Q9R256	Gene names	Map3k1, Mekk, Mekk1
Domain Architecture
Description	Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1).