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Network neighborhood for query Sequence : NPCL1_MOUSE

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NPCL1_MOUSE
SwissProt Accessions	Q6T3U4, Q5SVX1	Gene names	Npc1l1
Domain Architecture	No domain graphic available
Description	Niemann-Pick C1-like protein 1 precursor.
Rank Plots	Jump to hits sorted by θ Jump to hits sorted by NC score

Hits sorted by θ

NPC1_HUMAN
θ value	0 (rank : 1)	NC score	0.968164 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	19	Shared Neighborhood Hits	9
SwissProt Accessions	O15118, Q9P130	Gene names	NPC1
Domain Architecture
Description	Niemann-Pick C1 protein precursor.

NPC1_MOUSE
θ value	0 (rank : 2)	NC score	0.968062 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	18	Shared Neighborhood Hits	9
SwissProt Accessions	O35604, O35605	Gene names	Npc1
Domain Architecture
Description	Niemann-Pick C1 protein precursor.

NPCL1_HUMAN
θ value	0 (rank : 3)	NC score	0.996665 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	25	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UHC9, Q6R3Q4, Q9UHC8	Gene names	NPC1L1
Domain Architecture	No domain graphic available
Description	Niemann-Pick C1-like protein 1 precursor.

NPCL1_MOUSE
θ value	0 (rank : 4)	NC score	0.999962 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	Q6T3U4, Q5SVX1	Gene names	Npc1l1
Domain Architecture	No domain graphic available
Description	Niemann-Pick C1-like protein 1 precursor.

PTC2_MOUSE
θ value	3.88503e-19 (rank : 5)	NC score	0.569033 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	20	Shared Neighborhood Hits	9
SwissProt Accessions	O35595, Q546T0	Gene names	Ptch2
Domain Architecture
Description	Protein patched homolog 2 (PTC2).

PTC1_HUMAN
θ value	1.13037e-18 (rank : 6)	NC score	0.567093 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	37	Shared Neighborhood Hits	9
SwissProt Accessions	Q13635, Q13463, Q5VZC0	Gene names	PTCH1, PTCH
Domain Architecture
Description	Protein patched homolog 1 (PTC1) (PTC).

PTC2_HUMAN
θ value	2.5182e-18 (rank : 7)	NC score	0.563846 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	63	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6C5, O95341, O95856, Q5QP87, Q6UX14	Gene names	PTCH2
Domain Architecture
Description	Protein patched homolog 2 (PTC2).

PTC1_MOUSE
θ value	3.28887e-18 (rank : 8)	NC score	0.565977 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	43	Shared Neighborhood Hits	9
SwissProt Accessions	Q61115	Gene names	Ptch1, Ptch
Domain Architecture
Description	Protein patched homolog 1 (PTC1) (PTC).

SCAP_HUMAN
θ value	2.61198e-07 (rank : 9)	NC score	0.292011 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	368	Shared Neighborhood Hits	9
SwissProt Accessions	Q12770, Q8N2E0, Q8WUA1	Gene names	SCAP, KIAA0199
Domain Architecture
Description	Sterol regulatory element-binding protein cleavage-activating protein (SREBP cleavage-activating protein) (SCAP).

CY24B_MOUSE
θ value	1.81305 (rank : 10)	NC score	0.014013 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q61093	Gene names	Cybb, Cgd
Domain Architecture
Description	Cytochrome b-245 heavy chain (p22 phagocyte B-cytochrome) (Neutrophil cytochrome b 91 kDa polypeptide) (CGD91-phox) (gp91-phox) (gp91-1) (Heme-binding membrane glycoprotein gp91phox) (Cytochrome b(558) subunit beta) (Cytochrome b558 subunit beta).

KCNK7_MOUSE
θ value	3.0926 (rank : 11)	NC score	0.014102 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	53	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z2T1, Q9QXY0, Q9QYE8, Q9R1V1, Q9R242	Gene names	Kcnk7, Dpkch3, Kcnk6, Kcnk8, Knot1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 7 (Putative potassium channel DP3) (Double-pore K(+) channel 3) (Neuromuscular two p domain potassium channel).

NBEA_HUMAN
θ value	4.03905 (rank : 12)	NC score	0.014500 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	186	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NFP9, Q9HCM8, Q9NSU1, Q9NW98, Q9Y6J1	Gene names	NBEA, BCL8B, KIAA1544, LYST2
Domain Architecture
Description	Protein neurobeachin (Lysosomal-trafficking regulator 2) (Protein BCL8B).

NBEA_MOUSE
θ value	4.03905 (rank : 13)	NC score	0.014407 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	225	Shared Neighborhood Hits	3
SwissProt Accessions	Q9EPN1, Q8C931, Q9EPM9, Q9EPN0, Q9WVM9	Gene names	Nbea, Lyst2
Domain Architecture
Description	Protein neurobeachin (Lysosomal-trafficking regulator 2).

SRTD2_HUMAN
θ value	4.03905 (rank : 14)	NC score	0.018877 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	62	Shared Neighborhood Hits	2
SwissProt Accessions	Q14140	Gene names	SERTAD2, KIAA0127
Domain Architecture	No domain graphic available
Description	SERTA domain-containing protein 2 (Transcriptional regulator interacting with the PHD-bromodomain 2) (TRIP-Br2).

CAC1F_HUMAN
θ value	5.27518 (rank : 15)	NC score	0.004810 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	141	Shared Neighborhood Hits	2
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

MYO9B_HUMAN
θ value	5.27518 (rank : 16)	NC score	0.007040 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	641	Shared Neighborhood Hits	5
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

MYO9B_MOUSE
θ value	5.27518 (rank : 17)	NC score	0.007399 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	311	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

ACE2_MOUSE
θ value	6.88961 (rank : 18)	NC score	0.008218 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R0I0, Q99N70, Q99N71	Gene names	Ace2
Domain Architecture	No domain graphic available
Description	Angiotensin-converting enzyme 2 precursor (EC 3.4.17.-) (ACE-related carboxypeptidase).

ATBF1_MOUSE
θ value	6.88961 (rank : 19)	NC score	0.001471 (rank : 23)
Query Neighborhood Hits	21	Target Neighborhood Hits	1841	Shared Neighborhood Hits	4
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).

CSF3_HUMAN
θ value	8.99809 (rank : 20)	NC score	0.013689 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	P09919	Gene names	CSF3
Domain Architecture
Description	Granulocyte colony-stimulating factor precursor (G-CSF) (Pluripoietin) (Filgrastim) (Lenograstim).

UBP36_HUMAN
θ value	8.99809 (rank : 21)	NC score	0.004544 (rank : 22)
Query Neighborhood Hits	21	Target Neighborhood Hits	232	Shared Neighborhood Hits	3
SwissProt Accessions	Q9P275, Q8NDM8, Q9NVC8	Gene names	USP36, KIAA1453
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.1.2.15) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) (Deubiquitinating enzyme 36).

HMDH_HUMAN
θ value	θ > 10 (rank : 22)	NC score	0.092076 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P04035, Q8N190	Gene names	HMGCR
Domain Architecture
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase).

HMDH_MOUSE
θ value	θ > 10 (rank : 23)	NC score	0.091430 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q01237, Q5U4I2	Gene names	Hmgcr
Domain Architecture	No domain graphic available
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase).

Hits sorted by NC score

NPCL1_MOUSE
NC score	0.999962 (rank : 1)	θ value	0 (rank : 4)
Query Neighborhood Hits	21	Target Neighborhood Hits	21	Shared Neighborhood Hits	21
SwissProt Accessions	Q6T3U4, Q5SVX1	Gene names	Npc1l1
Domain Architecture	No domain graphic available
Description	Niemann-Pick C1-like protein 1 precursor.

NPCL1_HUMAN
NC score	0.996665 (rank : 2)	θ value	0 (rank : 3)
Query Neighborhood Hits	21	Target Neighborhood Hits	25	Shared Neighborhood Hits	11
SwissProt Accessions	Q9UHC9, Q6R3Q4, Q9UHC8	Gene names	NPC1L1
Domain Architecture	No domain graphic available
Description	Niemann-Pick C1-like protein 1 precursor.

NPC1_HUMAN
NC score	0.968164 (rank : 3)	θ value	0 (rank : 1)
Query Neighborhood Hits	21	Target Neighborhood Hits	19	Shared Neighborhood Hits	9
SwissProt Accessions	O15118, Q9P130	Gene names	NPC1
Domain Architecture
Description	Niemann-Pick C1 protein precursor.

NPC1_MOUSE
NC score	0.968062 (rank : 4)	θ value	0 (rank : 2)
Query Neighborhood Hits	21	Target Neighborhood Hits	18	Shared Neighborhood Hits	9
SwissProt Accessions	O35604, O35605	Gene names	Npc1
Domain Architecture
Description	Niemann-Pick C1 protein precursor.

PTC2_MOUSE
NC score	0.569033 (rank : 5)	θ value	3.88503e-19 (rank : 5)
Query Neighborhood Hits	21	Target Neighborhood Hits	20	Shared Neighborhood Hits	9
SwissProt Accessions	O35595, Q546T0	Gene names	Ptch2
Domain Architecture
Description	Protein patched homolog 2 (PTC2).

PTC1_HUMAN
NC score	0.567093 (rank : 6)	θ value	1.13037e-18 (rank : 6)
Query Neighborhood Hits	21	Target Neighborhood Hits	37	Shared Neighborhood Hits	9
SwissProt Accessions	Q13635, Q13463, Q5VZC0	Gene names	PTCH1, PTCH
Domain Architecture
Description	Protein patched homolog 1 (PTC1) (PTC).

PTC1_MOUSE
NC score	0.565977 (rank : 7)	θ value	3.28887e-18 (rank : 8)
Query Neighborhood Hits	21	Target Neighborhood Hits	43	Shared Neighborhood Hits	9
SwissProt Accessions	Q61115	Gene names	Ptch1, Ptch
Domain Architecture
Description	Protein patched homolog 1 (PTC1) (PTC).

PTC2_HUMAN
NC score	0.563846 (rank : 8)	θ value	2.5182e-18 (rank : 7)
Query Neighborhood Hits	21	Target Neighborhood Hits	63	Shared Neighborhood Hits	9
SwissProt Accessions	Q9Y6C5, O95341, O95856, Q5QP87, Q6UX14	Gene names	PTCH2
Domain Architecture
Description	Protein patched homolog 2 (PTC2).

SCAP_HUMAN
NC score	0.292011 (rank : 9)	θ value	2.61198e-07 (rank : 9)
Query Neighborhood Hits	21	Target Neighborhood Hits	368	Shared Neighborhood Hits	9
SwissProt Accessions	Q12770, Q8N2E0, Q8WUA1	Gene names	SCAP, KIAA0199
Domain Architecture
Description	Sterol regulatory element-binding protein cleavage-activating protein (SREBP cleavage-activating protein) (SCAP).

HMDH_HUMAN
NC score	0.092076 (rank : 10)	θ value	θ > 10 (rank : 22)
Query Neighborhood Hits	21	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	P04035, Q8N190	Gene names	HMGCR
Domain Architecture
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase).

HMDH_MOUSE
NC score	0.091430 (rank : 11)	θ value	θ > 10 (rank : 23)
Query Neighborhood Hits	21	Target Neighborhood Hits	13	Shared Neighborhood Hits	3
SwissProt Accessions	Q01237, Q5U4I2	Gene names	Hmgcr
Domain Architecture	No domain graphic available
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34) (HMG-CoA reductase).

SRTD2_HUMAN
NC score	0.018877 (rank : 12)	θ value	4.03905 (rank : 14)
Query Neighborhood Hits	21	Target Neighborhood Hits	62	Shared Neighborhood Hits	2
SwissProt Accessions	Q14140	Gene names	SERTAD2, KIAA0127
Domain Architecture	No domain graphic available
Description	SERTA domain-containing protein 2 (Transcriptional regulator interacting with the PHD-bromodomain 2) (TRIP-Br2).

NBEA_HUMAN
NC score	0.014500 (rank : 13)	θ value	4.03905 (rank : 12)
Query Neighborhood Hits	21	Target Neighborhood Hits	186	Shared Neighborhood Hits	3
SwissProt Accessions	Q8NFP9, Q9HCM8, Q9NSU1, Q9NW98, Q9Y6J1	Gene names	NBEA, BCL8B, KIAA1544, LYST2
Domain Architecture
Description	Protein neurobeachin (Lysosomal-trafficking regulator 2) (Protein BCL8B).

NBEA_MOUSE
NC score	0.014407 (rank : 14)	θ value	4.03905 (rank : 13)
Query Neighborhood Hits	21	Target Neighborhood Hits	225	Shared Neighborhood Hits	3
SwissProt Accessions	Q9EPN1, Q8C931, Q9EPM9, Q9EPN0, Q9WVM9	Gene names	Nbea, Lyst2
Domain Architecture
Description	Protein neurobeachin (Lysosomal-trafficking regulator 2).

KCNK7_MOUSE
NC score	0.014102 (rank : 15)	θ value	3.0926 (rank : 11)
Query Neighborhood Hits	21	Target Neighborhood Hits	53	Shared Neighborhood Hits	2
SwissProt Accessions	Q9Z2T1, Q9QXY0, Q9QYE8, Q9R1V1, Q9R242	Gene names	Kcnk7, Dpkch3, Kcnk6, Kcnk8, Knot1
Domain Architecture	No domain graphic available
Description	Potassium channel subfamily K member 7 (Putative potassium channel DP3) (Double-pore K(+) channel 3) (Neuromuscular two p domain potassium channel).

CY24B_MOUSE
NC score	0.014013 (rank : 16)	θ value	1.81305 (rank : 10)
Query Neighborhood Hits	21	Target Neighborhood Hits	15	Shared Neighborhood Hits	2
SwissProt Accessions	Q61093	Gene names	Cybb, Cgd
Domain Architecture
Description	Cytochrome b-245 heavy chain (p22 phagocyte B-cytochrome) (Neutrophil cytochrome b 91 kDa polypeptide) (CGD91-phox) (gp91-phox) (gp91-1) (Heme-binding membrane glycoprotein gp91phox) (Cytochrome b(558) subunit beta) (Cytochrome b558 subunit beta).

CSF3_HUMAN
NC score	0.013689 (rank : 17)	θ value	8.99809 (rank : 20)
Query Neighborhood Hits	21	Target Neighborhood Hits	4	Shared Neighborhood Hits	2
SwissProt Accessions	P09919	Gene names	CSF3
Domain Architecture
Description	Granulocyte colony-stimulating factor precursor (G-CSF) (Pluripoietin) (Filgrastim) (Lenograstim).

ACE2_MOUSE
NC score	0.008218 (rank : 18)	θ value	6.88961 (rank : 18)
Query Neighborhood Hits	21	Target Neighborhood Hits	20	Shared Neighborhood Hits	2
SwissProt Accessions	Q8R0I0, Q99N70, Q99N71	Gene names	Ace2
Domain Architecture	No domain graphic available
Description	Angiotensin-converting enzyme 2 precursor (EC 3.4.17.-) (ACE-related carboxypeptidase).

MYO9B_MOUSE
NC score	0.007399 (rank : 19)	θ value	5.27518 (rank : 17)
Query Neighborhood Hits	21	Target Neighborhood Hits	311	Shared Neighborhood Hits	4
SwissProt Accessions	Q9QY06, Q9QY07, Q9QY08, Q9QY09	Gene names	Myo9b, Myr5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

MYO9B_HUMAN
NC score	0.007040 (rank : 20)	θ value	5.27518 (rank : 16)
Query Neighborhood Hits	21	Target Neighborhood Hits	641	Shared Neighborhood Hits	5
SwissProt Accessions	Q13459, O75314, Q9NUJ2, Q9UHN0	Gene names	MYO9B, MYR5
Domain Architecture
Description	Myosin-9B (Myosin IXb) (Unconventional myosin-9b).

CAC1F_HUMAN
NC score	0.004810 (rank : 21)	θ value	5.27518 (rank : 15)
Query Neighborhood Hits	21	Target Neighborhood Hits	141	Shared Neighborhood Hits	2
SwissProt Accessions	O60840, O43901	Gene names	CACNA1F, CACNAF1
Domain Architecture
Description	Voltage-dependent L-type calcium channel subunit alpha-1F (Voltage- gated calcium channel subunit alpha Cav1.4).

UBP36_HUMAN
NC score	0.004544 (rank : 22)	θ value	8.99809 (rank : 21)
Query Neighborhood Hits	21	Target Neighborhood Hits	232	Shared Neighborhood Hits	3
SwissProt Accessions	Q9P275, Q8NDM8, Q9NVC8	Gene names	USP36, KIAA1453
Domain Architecture
Description	Ubiquitin carboxyl-terminal hydrolase 36 (EC 3.1.2.15) (Ubiquitin thioesterase 36) (Ubiquitin-specific-processing protease 36) (Deubiquitinating enzyme 36).

ATBF1_MOUSE
NC score	0.001471 (rank : 23)	θ value	6.88961 (rank : 19)
Query Neighborhood Hits	21	Target Neighborhood Hits	1841	Shared Neighborhood Hits	4
SwissProt Accessions	Q61329	Gene names	Atbf1
Domain Architecture
Description	Alpha-fetoprotein enhancer-binding protein (AT motif-binding factor) (AT-binding transcription factor 1).